ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	synapsis (GO:0007129)	8.49163275
2	piRNA metabolic process (GO:0034587)	7.63903618
3	male meiosis I (GO:0007141)	7.11249844
4	chromosome organization involved in meiosis (GO:0070192)	6.79137447
5	DNA methylation involved in gamete generation (GO:0043046)	6.77466123
6	male meiosis (GO:0007140)	6.66639338
7	synaptonemal complex assembly (GO:0007130)	5.85754703
8	meiosis I (GO:0007127)	5.53801316
9	synaptonemal complex organization (GO:0070193)	5.41948586
10	meiotic nuclear division (GO:0007126)	5.22959004
11	regulation of meiosis I (GO:0060631)	5.21891605
12	DNA synthesis involved in DNA repair (GO:0000731)	5.12566257
13	regulation of mesoderm development (GO:2000380)	4.72043869
14	negative regulation of activin receptor signaling pathway (GO:0032926)	4.63292659
15	reciprocal DNA recombination (GO:0035825)	4.62636796
16	reciprocal meiotic recombination (GO:0007131)	4.62636796
17	cell migration involved in gastrulation (GO:0042074)	4.54952285
18	meiotic cell cycle process (GO:1903046)	4.26284428
19	sex differentiation (GO:0007548)	4.25124395
20	nodal signaling pathway (GO:0038092)	4.18923204
21	negative regulation of multicellular organism growth (GO:0040015)	3.85854230
22	kynurenine metabolic process (GO:0070189)	3.85651650
23	indole-containing compound catabolic process (GO:0042436)	3.83286580
24	indolalkylamine catabolic process (GO:0046218)	3.83286580
25	tryptophan catabolic process (GO:0006569)	3.83286580
26	resolution of meiotic recombination intermediates (GO:0000712)	3.80881631
27	anterior/posterior axis specification, embryo (GO:0008595)	3.75470126
28	acrosome assembly (GO:0001675)	3.71188067
29	gene silencing by RNA (GO:0031047)	3.70204754
30	sister chromatid cohesion (GO:0007062)	3.67890595
31	DNA double-strand break processing (GO:0000729)	3.62552291
32	regulation of establishment of cell polarity (GO:2000114)	3.61855751
33	negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)	3.59913249
34	sequestering of extracellular ligand from receptor (GO:0035581)	3.50835687
35	regulation of timing of cell differentiation (GO:0048505)	3.43733262
36	regulation of memory T cell differentiation (GO:0043380)	3.42277727
37	DNA replication checkpoint (GO:0000076)	3.41296189
38	meiotic chromosome segregation (GO:0045132)	3.38226751
39	regulation of activin receptor signaling pathway (GO:0032925)	3.37556057
40	regulation of development, heterochronic (GO:0040034)	3.36462648
41	histone exchange (GO:0043486)	3.34869634
42	response to pheromone (GO:0019236)	3.33299772
43	regulation of establishment or maintenance of cell polarity (GO:0032878)	3.22839563
44	tryptophan metabolic process (GO:0006568)	3.20552687
45	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	3.19140559
46	mitochondrial fragmentation involved in apoptotic process (GO:0043653)	3.17004150
47	protein localization to cilium (GO:0061512)	3.12004743
48	aspartate family amino acid catabolic process (GO:0009068)	3.04415876
49	indolalkylamine metabolic process (GO:0006586)	3.01252010
50	spermatid development (GO:0007286)	2.99027472
51	genitalia morphogenesis (GO:0035112)	2.98880444
52	sperm motility (GO:0030317)	2.97450327
53	regulation of acyl-CoA biosynthetic process (GO:0050812)	2.90618514
54	signal transduction involved in regulation of gene expression (GO:0023019)	2.90591683
55	photoreceptor cell maintenance (GO:0045494)	2.85338308
56	epithelial cilium movement (GO:0003351)	2.84977324
57	mitochondrial fission (GO:0000266)	2.84210273
58	negative regulation of cell cycle G2/M phase transition (GO:1902750)	2.83803479
59	regulation of cofactor metabolic process (GO:0051193)	2.82718665
60	regulation of coenzyme metabolic process (GO:0051196)	2.82718665
61	positive regulation of mitochondrial fission (GO:0090141)	2.80361960
62	positive regulation of meiosis (GO:0045836)	2.76210843
63	lipid particle organization (GO:0034389)	2.75243129
64	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.73277914
65	DNA methylation (GO:0006306)	2.72619180
66	DNA alkylation (GO:0006305)	2.72619180
67	iron-sulfur cluster assembly (GO:0016226)	2.72589178
68	metallo-sulfur cluster assembly (GO:0031163)	2.72589178
69	sphingoid metabolic process (GO:0046519)	2.70428654
70	somite rostral/caudal axis specification (GO:0032525)	2.67592892
71	regulation of MHC class I biosynthetic process (GO:0045343)	2.66709970
72	embryonic pattern specification (GO:0009880)	2.65644376
73	positive regulation of meiotic cell cycle (GO:0051446)	2.65612835
74	ADP metabolic process (GO:0046031)	2.64283647
75	cellular biogenic amine catabolic process (GO:0042402)	2.64185743
76	amine catabolic process (GO:0009310)	2.64185743
77	DNA methylation or demethylation (GO:0044728)	2.60718239
78	neural tube formation (GO:0001841)	2.60617323
79	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.58129435
80	sphingosine metabolic process (GO:0006670)	2.53785055
81	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.52955738
82	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.50367556
83	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.50367556
84	regulation of translation, ncRNA-mediated (GO:0045974)	2.50367556
85	female gamete generation (GO:0007292)	2.49304478
86	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.48354828
87	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.48354828
88	anterior/posterior axis specification (GO:0009948)	2.46798514
89	protein-chromophore linkage (GO:0018298)	2.45021739
90	detection of light stimulus involved in visual perception (GO:0050908)	2.41084540
91	detection of light stimulus involved in sensory perception (GO:0050962)	2.41084540
92	regulation of cilium movement (GO:0003352)	2.40808062
93	lysine catabolic process (GO:0006554)	2.39513710
94	lysine metabolic process (GO:0006553)	2.39513710
95	intraciliary transport (GO:0042073)	2.37698736
96	cilium morphogenesis (GO:0060271)	2.36970208
97	aromatic amino acid family catabolic process (GO:0009074)	2.36758760
98	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.35346499
99	prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:006052	2.34522298
100	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.34331082

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IGF1R_20145208_ChIP-Seq_DFB_Human	3.78204520
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.68929205
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.27403782
4	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.11180496
5	VDR_22108803_ChIP-Seq_LS180_Human	2.95089529
6	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.89764634
7	GBX2_23144817_ChIP-Seq_PC3_Human	2.84311742
8	FUS_26573619_Chip-Seq_HEK293_Human	2.71181112
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.63058766
10	TAF15_26573619_Chip-Seq_HEK293_Human	2.56079149
11	BCAT_22108803_ChIP-Seq_LS180_Human	2.42783415
12	ER_23166858_ChIP-Seq_MCF-7_Human	2.41587695
13	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.36809143
14	P300_19829295_ChIP-Seq_ESCs_Human	2.29677460
15	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.26147210
16	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.12924423
17	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.93413109
18	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.91913578
19	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.90494190
20	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.87933810
21	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.82040196
22	AR_25329375_ChIP-Seq_VCAP_Human	1.80282384
23	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.78890869
24	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.77202888
25	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.76945748
26	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.71062701
27	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.69292599
28	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.63885685
29	EWS_26573619_Chip-Seq_HEK293_Human	1.62592029
30	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.58687385
31	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.57967320
32	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.57967320
33	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.57967320
34	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.56440134
35	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.56218007
36	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.55511937
37	STAT3_23295773_ChIP-Seq_U87_Human	1.55106162
38	RUNX2_22187159_ChIP-Seq_PCA_Human	1.51161774
39	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.47714623
40	TCF4_23295773_ChIP-Seq_U87_Human	1.46873659
41	RNF2_27304074_Chip-Seq_NSC_Mouse	1.45076749
42	TCF4_22108803_ChIP-Seq_LS180_Human	1.44920413
43	SMAD4_21799915_ChIP-Seq_A2780_Human	1.44611403
44	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.43184381
45	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.43145652
46	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.39685025
47	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.39682919
48	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.38109654
49	CBP_20019798_ChIP-Seq_JUKART_Human	1.38109654
50	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.36628692
51	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.36628692
52	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.35801831
53	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.34395826
54	NANOG_19829295_ChIP-Seq_ESCs_Human	1.34215856
55	SOX2_19829295_ChIP-Seq_ESCs_Human	1.34215856
56	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.33870698
57	* TP53_22573176_ChIP-Seq_HFKS_Human	1.32666304
58	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.29821424
59	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.29656497
60	MYC_18940864_ChIP-ChIP_HL60_Human	1.28384029
61	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.27467260
62	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.27466895
63	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.26776340
64	IRF1_19129219_ChIP-ChIP_H3396_Human	1.25132414
65	CDX2_22108803_ChIP-Seq_LS180_Human	1.20333309
66	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.18191976
67	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.18097027
68	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.17991268
69	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.17806925
70	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.15755609
71	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.14333986
72	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.14290486
73	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.13038177
74	HOXB7_26014856_ChIP-Seq_BT474_Human	1.11295685
75	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.09300478
76	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.08828381
77	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.08111027
78	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.07166088
79	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.07100813
80	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.06673209
81	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.06673209
82	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.06413128
83	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.05336972
84	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.04330213
85	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.04118990
86	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.01476795
87	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.00548456
88	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.98905988
89	EZH2_22144423_ChIP-Seq_EOC_Human	0.98795476
90	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.98133091
91	ERA_21632823_ChIP-Seq_H3396_Human	0.97595103
92	AHR_22903824_ChIP-Seq_MCF-7_Human	0.97265317
93	GABP_17652178_ChIP-ChIP_JURKAT_Human	0.96596590
94	NCOR_22424771_ChIP-Seq_293T_Human	0.96540554
95	AR_20517297_ChIP-Seq_VCAP_Human	0.95203235
96	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.94902217
97	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.94443766
98	AR_21572438_ChIP-Seq_LNCaP_Human	0.93018026
99	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.92488404
100	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.89873278

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	4.86901160
2	MP0003890_abnormal_embryonic-extraembry	4.12401302
3	MP0002736_abnormal_nociception_after	3.18655903
4	MP0008004_abnormal_stomach_pH	2.88408705
5	MP0000569_abnormal_digit_pigmentation	2.83774640
6	MP0003136_yellow_coat_color	2.69655057
7	MP0002160_abnormal_reproductive_system	2.69279152
8	MP0001968_abnormal_touch/_nociception	2.64874351
9	MP0008058_abnormal_DNA_repair	2.36973347
10	MP0002210_abnormal_sex_determination	2.34286316
11	MP0004133_heterotaxia	2.29372843
12	MP0001929_abnormal_gametogenesis	2.24392813
13	MP0005410_abnormal_fertilization	2.19526175
14	MP0003698_abnormal_male_reproductive	2.11985794
15	MP0000427_abnormal_hair_cycle	1.98293413
16	MP0003880_abnormal_central_pattern	1.97712415
17	MP0001145_abnormal_male_reproductive	1.85660401
18	MP0000653_abnormal_sex_gland	1.83185738
19	MP0006035_abnormal_mitochondrial_morpho	1.79560241
20	MP0001486_abnormal_startle_reflex	1.78551647
21	MP0003011_delayed_dark_adaptation	1.71824854
22	MP0002837_dystrophic_cardiac_calcinosis	1.67198439
23	MP0005394_taste/olfaction_phenotype	1.64824834
24	MP0005499_abnormal_olfactory_system	1.64824834
25	MP0001986_abnormal_taste_sensitivity	1.64403754
26	MP0003137_abnormal_impulse_conducting	1.63765088
27	MP0005551_abnormal_eye_electrophysiolog	1.63344950
28	MP0003119_abnormal_digestive_system	1.63150848
29	MP0005389_reproductive_system_phenotype	1.61869271
30	MP0003718_maternal_effect	1.54195230
31	MP0002653_abnormal_ependyma_morphology	1.53109260
32	MP0002102_abnormal_ear_morphology	1.46436723
33	MP0003646_muscle_fatigue	1.40451588
34	MP0008995_early_reproductive_senescence	1.36535122
35	MP0005253_abnormal_eye_physiology	1.35778505
36	MP0009046_muscle_twitch	1.35100549
37	MP0006072_abnormal_retinal_apoptosis	1.34011918
38	MP0005171_absent_coat_pigmentation	1.33841652
39	MP0010030_abnormal_orbit_morphology	1.32456777
40	MP0009745_abnormal_behavioral_response	1.31157997
41	MP0001984_abnormal_olfaction	1.30105932
42	MP0008789_abnormal_olfactory_epithelium	1.28064367
43	MP0000383_abnormal_hair_follicle	1.25155336
44	MP0002638_abnormal_pupillary_reflex	1.21888809
45	MP0002161_abnormal_fertility/fecundity	1.18503743
46	MP0003693_abnormal_embryo_hatching	1.18036599
47	MP0005646_abnormal_pituitary_gland	1.18007575
48	MP0001485_abnormal_pinna_reflex	1.17915642
49	MP0001501_abnormal_sleep_pattern	1.17713927
50	MP0006292_abnormal_olfactory_placode	1.11267056
51	MP0000647_abnormal_sebaceous_gland	1.09860743
52	MP0002272_abnormal_nervous_system	1.08942857
53	MP0004043_abnormal_pH_regulation	1.08592581
54	MP0003252_abnormal_bile_duct	1.08483924
55	MP0001119_abnormal_female_reproductive	1.05497668
56	MP0001764_abnormal_homeostasis	1.03482804
57	MP0002234_abnormal_pharynx_morphology	1.01447650
58	MP0002184_abnormal_innervation	1.00885703
59	MP0006276_abnormal_autonomic_nervous	1.00415433
60	MP0003941_abnormal_skin_development	0.98880655
61	MP0004264_abnormal_extraembryonic_tissu	0.98567491
62	MP0001919_abnormal_reproductive_system	0.98561454
63	MP0003937_abnormal_limbs/digits/tail_de	0.98370550
64	MP0003938_abnormal_ear_development	0.98237802
65	MP0008932_abnormal_embryonic_tissue	0.97393776
66	MP0000358_abnormal_cell_content/	0.97037233
67	MP0001529_abnormal_vocalization	0.96868170
68	MP0005174_abnormal_tail_pigmentation	0.96619767
69	MP0003878_abnormal_ear_physiology	0.96266195
70	MP0005377_hearing/vestibular/ear_phenot	0.96266195
71	MP0002067_abnormal_sensory_capabilities	0.93001997
72	MP0008872_abnormal_physiological_respon	0.92688079
73	MP0006036_abnormal_mitochondrial_physio	0.92273492
74	MP0004085_abnormal_heartbeat	0.90404365
75	MP0002233_abnormal_nose_morphology	0.90302296
76	MP0002752_abnormal_somatic_nervous	0.87251594
77	MP0002751_abnormal_autonomic_nervous	0.87095760
78	MP0002572_abnormal_emotion/affect_behav	0.86725769
79	MP0010094_abnormal_chromosome_stability	0.85144831
80	MP0003635_abnormal_synaptic_transmissio	0.84221217
81	MP0002938_white_spotting	0.83703898
82	MP0005423_abnormal_somatic_nervous	0.83608429
83	MP0003195_calcinosis	0.83338270
84	MP0003699_abnormal_female_reproductive	0.82051282
85	MP0009697_abnormal_copulation	0.80025862
86	MP0000049_abnormal_middle_ear	0.77907412
87	MP0008057_abnormal_DNA_replication	0.77201776
88	MP0000026_abnormal_inner_ear	0.76986261
89	MP0002229_neurodegeneration	0.74635937
90	MP0005647_abnormal_sex_gland	0.74115675
91	MP0002735_abnormal_chemical_nociception	0.73310471
92	MP0001286_abnormal_eye_development	0.72797453
93	MP0003567_abnormal_fetal_cardiomyocyte	0.72737807
94	MP0003936_abnormal_reproductive_system	0.72081442
95	MP0000470_abnormal_stomach_morphology	0.71360945
96	MP0001188_hyperpigmentation	0.70937621
97	MP0004215_abnormal_myocardial_fiber	0.70855420
98	MP0004147_increased_porphyrin_level	0.70522031
99	MP0003786_premature_aging	0.68917576
100	MP0000631_abnormal_neuroendocrine_gland	0.68598311

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Oligodactyly (hands) (HP:0001180)	6.41155803
2	Intestinal atresia (HP:0011100)	5.54649130
3	Double outlet right ventricle (HP:0001719)	5.06147006
4	Congenital malformation of the right heart (HP:0011723)	5.06147006
5	Nuclear cataract (HP:0100018)	4.58405842
6	Oligodactyly (HP:0012165)	4.27835352
7	Abnormality of the parathyroid morphology (HP:0011766)	4.19014780
8	Esophageal atresia (HP:0002032)	4.01987250
9	Progressive inability to walk (HP:0002505)	3.93578579
10	Aqueductal stenosis (HP:0002410)	3.72935237
11	Labial hypoplasia (HP:0000066)	3.57072357
12	Chin dimple (HP:0010751)	3.40741289
13	Type II lissencephaly (HP:0007260)	3.32716891
14	Hypoplastic female external genitalia (HP:0012815)	3.32182595
15	Genetic anticipation (HP:0003743)	3.25222152
16	Inability to walk (HP:0002540)	3.13143116
17	Absent radius (HP:0003974)	2.99655157
18	Gastrointestinal atresia (HP:0002589)	2.95735951
19	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.91023225
20	Anencephaly (HP:0002323)	2.89236135
21	Absent forearm bone (HP:0003953)	2.87895432
22	Aplasia involving forearm bones (HP:0009822)	2.87895432
23	Abnormality of the labia (HP:0000058)	2.76618736
24	Retinal dysplasia (HP:0007973)	2.75534873
25	Gaze-evoked nystagmus (HP:0000640)	2.74736207
26	Pancreatic cysts (HP:0001737)	2.66229556
27	Abdominal situs inversus (HP:0003363)	2.63221879
28	Abnormality of abdominal situs (HP:0011620)	2.63221879
29	Abnormality of the renal cortex (HP:0011035)	2.55943279
30	Urinary bladder sphincter dysfunction (HP:0002839)	2.53228867
31	Anophthalmia (HP:0000528)	2.46702900
32	Down-sloping shoulders (HP:0200021)	2.42659482
33	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.42541769
34	Horseshoe kidney (HP:0000085)	2.40445489
35	Progressive cerebellar ataxia (HP:0002073)	2.39950998
36	Anal stenosis (HP:0002025)	2.35971695
37	Chromsome breakage (HP:0040012)	2.35643380
38	Optic nerve hypoplasia (HP:0000609)	2.34030631
39	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.33408252
40	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.33408252
41	Lissencephaly (HP:0001339)	2.33324126
42	Abnormality of the duodenum (HP:0002246)	2.27202319
43	Hyperventilation (HP:0002883)	2.25989689
44	Bifid tongue (HP:0010297)	2.22448233
45	Cupped ear (HP:0000378)	2.22229597
46	Deep palmar crease (HP:0006191)	2.21074994
47	Abnormality of alanine metabolism (HP:0010916)	2.20631186
48	Hyperalaninemia (HP:0003348)	2.20631186
49	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.20631186
50	Action tremor (HP:0002345)	2.18610928
51	Focal seizures (HP:0007359)	2.17590711
52	Zonular cataract (HP:0010920)	2.17244968
53	Dialeptic seizures (HP:0011146)	2.17088450
54	Abnormality of midbrain morphology (HP:0002418)	2.16220275
55	Molar tooth sign on MRI (HP:0002419)	2.16220275
56	Hemivertebrae (HP:0002937)	2.15435499
57	Focal motor seizures (HP:0011153)	2.14680676
58	Nephronophthisis (HP:0000090)	2.11262729
59	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.11026760
60	Hypoplastic labia majora (HP:0000059)	2.06086976
61	Renal cortical cysts (HP:0000803)	2.04986148
62	Abnormality of the ileum (HP:0001549)	2.04277304
63	Preaxial hand polydactyly (HP:0001177)	2.02846869
64	Pendular nystagmus (HP:0012043)	2.02826255
65	Anosmia (HP:0000458)	2.01307422
66	True hermaphroditism (HP:0010459)	2.00916114
67	Renal hypoplasia (HP:0000089)	1.98918704
68	Pachygyria (HP:0001302)	1.97893110
69	Medial flaring of the eyebrow (HP:0010747)	1.96400639
70	Abnormality of the renal medulla (HP:0100957)	1.95957733
71	Pancreatic fibrosis (HP:0100732)	1.95519444
72	Anterior segment dysgenesis (HP:0007700)	1.95029225
73	Impaired vibratory sensation (HP:0002495)	1.94331551
74	Meckel diverticulum (HP:0002245)	1.93832681
75	Mixed hearing impairment (HP:0000410)	1.92475802
76	Volvulus (HP:0002580)	1.92162879
77	Triphalangeal thumb (HP:0001199)	1.90975245
78	Protruding tongue (HP:0010808)	1.87077579
79	Broad-based gait (HP:0002136)	1.86911435
80	Aplasia/Hypoplasia of the earlobes (HP:0009906)	1.84640045
81	Abnormality of the labia minora (HP:0012880)	1.84341349
82	Ependymoma (HP:0002888)	1.84321256
83	Dandy-Walker malformation (HP:0001305)	1.84241119
84	Dysmetric saccades (HP:0000641)	1.84006985
85	Abnormality of the corticospinal tract (HP:0002492)	1.83731289
86	Growth hormone deficiency (HP:0000824)	1.82634060
87	Bifid scrotum (HP:0000048)	1.81720917
88	Dysdiadochokinesis (HP:0002075)	1.81145389
89	Cerebellar dysplasia (HP:0007033)	1.80991385
90	Abnormality of the labia majora (HP:0012881)	1.80989023
91	Abnormality of macular pigmentation (HP:0008002)	1.78314190
92	Abnormality of chromosome stability (HP:0003220)	1.77029081
93	Ectopic kidney (HP:0000086)	1.75933794
94	Congenital primary aphakia (HP:0007707)	1.74602117
95	Cleft eyelid (HP:0000625)	1.74565650
96	Short thumb (HP:0009778)	1.74210744
97	Gait imbalance (HP:0002141)	1.73990707
98	Gonadotropin excess (HP:0000837)	1.73652590
99	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	1.73401965
100	Small hand (HP:0200055)	1.72692909

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.43723358
2	CDK19	4.20418599
3	PINK1	4.09520400
4	ERBB4	3.87716323
5	OXSR1	3.10810554
6	BMPR1B	3.06227028
7	ACVR1B	3.00045660
8	STK38L	2.94906669
9	PNCK	2.71498424
10	PDK2	2.58126261
11	ZAK	2.48845775
12	LATS1	2.42699039
13	GRK1	2.15278370
14	TRIM28	2.14574509
15	BCR	2.05018310
16	WNK3	2.01309755
17	MAPK13	1.66212667
18	ADRBK2	1.62716420
19	CASK	1.54126153
20	PRKD3	1.32428389
21	MST4	1.31293627
22	INSRR	1.25582471
23	STK38	1.20532638
24	STK39	1.19656126
25	EIF2AK3	1.18521736
26	PLK2	1.16032050
27	NUAK1	1.13581806
28	PBK	1.12931812
29	MET	1.06010011
30	TGFBR1	1.04991674
31	TNK2	0.97593851
32	MKNK2	0.96425478
33	AKT3	0.93650401
34	MAP3K4	0.93421457
35	MAP4K2	0.90989705
36	SRPK1	0.89430095
37	MARK1	0.88492318
38	TNIK	0.87524657
39	PRKCE	0.86995990
40	MAPKAPK5	0.84570593
41	MAP2K7	0.82270461
42	STK3	0.81655250
43	BCKDK	0.81320311
44	FLT3	0.81268262
45	NEK1	0.80537415
46	TSSK6	0.77331467
47	MKNK1	0.76325889
48	ADRBK1	0.75544814
49	TLK1	0.74163018
50	WEE1	0.73798321
51	WNK4	0.73231442
52	PLK4	0.73131156
53	VRK1	0.71899415
54	FER	0.70750311
55	PTK2B	0.70570288
56	NME1	0.68883020
57	MARK3	0.66811285
58	PLK1	0.65813065
59	PAK3	0.63450478
60	PRKCI	0.62975271
61	MAP3K7	0.62928926
62	PRKCG	0.61322759
63	STK16	0.60429713
64	PKN2	0.56156976
65	BRSK2	0.54348244
66	CAMK1G	0.53737170
67	CSNK1G2	0.53332044
68	CSNK1A1L	0.51587295
69	TTK	0.51008356
70	BMX	0.49274300
71	CSNK1G1	0.47814869
72	ATR	0.47814835
73	CCNB1	0.47611740
74	NLK	0.46208151
75	CDK3	0.44938417
76	CSNK1G3	0.44835400
77	SIK3	0.43550210
78	STK11	0.43495140
79	FGR	0.43399301
80	RPS6KA5	0.42992380
81	ATM	0.41993135
82	MELK	0.41344891
83	PLK3	0.38035720
84	FGFR1	0.37121758
85	CAMKK2	0.37097871
86	CAMK2A	0.34297561
87	NEK2	0.32550657
88	DYRK3	0.31913014
89	BRD4	0.31075984
90	EGFR	0.28990008
91	ERBB3	0.28934552
92	NTRK3	0.28717804
93	DYRK2	0.27335538
94	CHEK1	0.26915629
95	OBSCN	0.26257456
96	PKN1	0.25688317
97	CDK5	0.25197476
98	DYRK1A	0.24203682
99	CSNK1A1	0.22979493
100	CAMK1	0.20780098

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.74162074
2	Propanoate metabolism_Homo sapiens_hsa00640	2.63569484
3	Phototransduction_Homo sapiens_hsa04744	2.55971990
4	Fanconi anemia pathway_Homo sapiens_hsa03460	2.53370952
5	Homologous recombination_Homo sapiens_hsa03440	2.51119879
6	Butanoate metabolism_Homo sapiens_hsa00650	2.48637674
7	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.12341290
8	Nitrogen metabolism_Homo sapiens_hsa00910	1.97396790
9	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.95378533
10	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.92831131
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.90373184
12	Non-homologous end-joining_Homo sapiens_hsa03450	1.89217427
13	Nicotine addiction_Homo sapiens_hsa05033	1.87837139
14	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.85836271
15	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.81128951
16	Basal transcription factors_Homo sapiens_hsa03022	1.81061357
17	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.80343926
18	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.71489949
19	Pyruvate metabolism_Homo sapiens_hsa00620	1.66810583
20	Tryptophan metabolism_Homo sapiens_hsa00380	1.62295482
21	beta-Alanine metabolism_Homo sapiens_hsa00410	1.58935928
22	Olfactory transduction_Homo sapiens_hsa04740	1.56555167
23	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.54251795
24	Taste transduction_Homo sapiens_hsa04742	1.52990408
25	Selenocompound metabolism_Homo sapiens_hsa00450	1.51690418
26	Linoleic acid metabolism_Homo sapiens_hsa00591	1.43889199
27	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.38740648
28	Circadian rhythm_Homo sapiens_hsa04710	1.37017802
29	Oocyte meiosis_Homo sapiens_hsa04114	1.33456744
30	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.26388831
31	Ether lipid metabolism_Homo sapiens_hsa00565	1.24890504
32	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.20131186
33	Protein export_Homo sapiens_hsa03060	1.14690957
34	Peroxisome_Homo sapiens_hsa04146	1.14073834
35	ABC transporters_Homo sapiens_hsa02010	1.12306587
36	Retinol metabolism_Homo sapiens_hsa00830	1.11516985
37	Sphingolipid metabolism_Homo sapiens_hsa00600	1.11022353
38	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.07638032
39	Mismatch repair_Homo sapiens_hsa03430	1.06141634
40	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.02706906
41	RNA degradation_Homo sapiens_hsa03018	1.02685410
42	Proteasome_Homo sapiens_hsa03050	1.02648080
43	Fatty acid degradation_Homo sapiens_hsa00071	1.01883646
44	Collecting duct acid secretion_Homo sapiens_hsa04966	1.01198413
45	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.01171966
46	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.99591314
47	RNA transport_Homo sapiens_hsa03013	0.99481647
48	Regulation of autophagy_Homo sapiens_hsa04140	0.98657865
49	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.96852125
50	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.96062903
51	RNA polymerase_Homo sapiens_hsa03020	0.94997488
52	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.93872175
53	Fatty acid metabolism_Homo sapiens_hsa01212	0.93853685
54	Morphine addiction_Homo sapiens_hsa05032	0.93294041
55	Calcium signaling pathway_Homo sapiens_hsa04020	0.92401130
56	Fatty acid elongation_Homo sapiens_hsa00062	0.91819669
57	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.90577745
58	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.90074636
59	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.88793749
60	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.85714672
61	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.83326975
62	Sulfur relay system_Homo sapiens_hsa04122	0.81123381
63	GABAergic synapse_Homo sapiens_hsa04727	0.78496375
64	Lysine degradation_Homo sapiens_hsa00310	0.77875277
65	Steroid biosynthesis_Homo sapiens_hsa00100	0.77125007
66	Purine metabolism_Homo sapiens_hsa00230	0.76883005
67	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.76224779
68	Cell cycle_Homo sapiens_hsa04110	0.75974281
69	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.72708164
70	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.72594378
71	Nucleotide excision repair_Homo sapiens_hsa03420	0.71930492
72	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.71030896
73	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.70645803
74	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.70575446
75	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.70035135
76	Caffeine metabolism_Homo sapiens_hsa00232	0.69692269
77	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.69670190
78	Circadian entrainment_Homo sapiens_hsa04713	0.68562189
79	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.68092603
80	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.65542288
81	Chemical carcinogenesis_Homo sapiens_hsa05204	0.61886576
82	Glutamatergic synapse_Homo sapiens_hsa04724	0.60220529
83	Metabolic pathways_Homo sapiens_hsa01100	0.59780033
84	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.59039982
85	Glycerolipid metabolism_Homo sapiens_hsa00561	0.56978971
86	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.54502861
87	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.53621237
88	Base excision repair_Homo sapiens_hsa03410	0.53528798
89	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.52553572
90	Arginine and proline metabolism_Homo sapiens_hsa00330	0.49681824
91	Glucagon signaling pathway_Homo sapiens_hsa04922	0.46961536
92	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.45313169
93	mRNA surveillance pathway_Homo sapiens_hsa03015	0.44154960
94	Fat digestion and absorption_Homo sapiens_hsa04975	0.43493242
95	p53 signaling pathway_Homo sapiens_hsa04115	0.42873375
96	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.41994372
97	Gastric acid secretion_Homo sapiens_hsa04971	0.40624172
98	Salivary secretion_Homo sapiens_hsa04970	0.40259414
99	Pyrimidine metabolism_Homo sapiens_hsa00240	0.39951817
100	Wnt signaling pathway_Homo sapiens_hsa04310	0.39534302

CXADRP3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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