CXCL10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of interferon-alpha production (GO:0032727)6.02023943
2positive regulation by symbiont of host defense response (GO:0052509)6.01887314
3modulation by symbiont of host defense response (GO:0052031)6.01887314
4modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.01887314
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.01887314
6positive regulation by organism of defense response of other organism involved in symbiotic interact6.01887314
7modulation by symbiont of host immune response (GO:0052553)6.01887314
8cellular response to interferon-alpha (GO:0035457)5.99146906
9response to peptidoglycan (GO:0032494)5.78931642
10regulation of interferon-alpha production (GO:0032647)5.76508147
11cellular response to type I interferon (GO:0071357)5.68651437
12type I interferon signaling pathway (GO:0060337)5.68651437
13response to type I interferon (GO:0034340)5.61295725
14regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)5.40319018
15positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)5.40319018
16cellular response to exogenous dsRNA (GO:0071360)5.38106980
17regulation of MHC class I biosynthetic process (GO:0045343)5.31961593
18response to interferon-alpha (GO:0035455)5.28375872
19* positive regulation of cAMP-mediated signaling (GO:0043950)5.21336214
20negative regulation of viral genome replication (GO:0045071)5.11169135
21regulation of T-helper 1 cell differentiation (GO:0045625)5.04944802
22regulation of type 2 immune response (GO:0002828)4.88490187
23natural killer cell activation involved in immune response (GO:0002323)4.85030483
24neutrophil activation involved in immune response (GO:0002283)4.78228260
25lipopolysaccharide-mediated signaling pathway (GO:0031663)4.73828949
26* T cell migration (GO:0072678)4.70246610
27antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.69514903
28positive regulation of chemokine biosynthetic process (GO:0045080)4.69101958
29regulation of viral genome replication (GO:0045069)4.63580889
30cellular response to interferon-beta (GO:0035458)4.63528603
31immunoglobulin mediated immune response (GO:0016064)4.63169717
32positive regulation of type 2 immune response (GO:0002830)4.55793325
33regulation of T cell tolerance induction (GO:0002664)4.47948421
34negative regulation of interleukin-12 production (GO:0032695)4.40663246
35regulation of chemokine biosynthetic process (GO:0045073)4.37051844
36response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.33537857
37response to host immune response (GO:0052572)4.33537857
38response to exogenous dsRNA (GO:0043330)4.31834395
39positive regulation of interferon-gamma biosynthetic process (GO:0045078)4.27258386
40regulation of activation of Janus kinase activity (GO:0010533)4.25463057
41positive regulation of interferon-beta production (GO:0032728)4.21926572
42* lymphocyte chemotaxis (GO:0048247)4.19544676
43response to interferon-beta (GO:0035456)4.19405285
44positive regulation of natural killer cell differentiation (GO:0032825)4.16443339
45positive regulation of heat generation (GO:0031652)4.14864341
46positive regulation of interleukin-17 production (GO:0032740)4.08372538
47defense response to protozoan (GO:0042832)4.04246417
48cellular response to virus (GO:0098586)4.03506228
49regulation of fever generation (GO:0031620)4.03051818
50response to interferon-gamma (GO:0034341)4.02518957
51macrophage activation involved in immune response (GO:0002281)3.99498876
52positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.99447846
53granulocyte activation (GO:0036230)3.88858139
54positive regulation of toll-like receptor signaling pathway (GO:0034123)3.86558289
55regulation of interferon-beta biosynthetic process (GO:0045357)3.85906159
56eosinophil chemotaxis (GO:0048245)3.84334757
57T-helper 1 type immune response (GO:0042088)3.83957361
58monocyte chemotaxis (GO:0002548)3.82928745
59response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.81539349
60response to host (GO:0075136)3.81539349
61response to host defenses (GO:0052200)3.81539349
62positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.80288937
63regulation of mononuclear cell migration (GO:0071675)3.79595735
64negative regulation of T cell mediated immunity (GO:0002710)3.79086536
65interferon-gamma-mediated signaling pathway (GO:0060333)3.76650191
66positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.76084215
67natural killer cell mediated cytotoxicity (GO:0042267)3.72323490
68natural killer cell mediated immunity (GO:0002228)3.72323490
69regulation of tolerance induction (GO:0002643)3.71752358
70hydrogen peroxide biosynthetic process (GO:0050665)3.70996631
71regulation of interferon-gamma biosynthetic process (GO:0045072)3.68324812
72regulation of RIG-I signaling pathway (GO:0039535)3.67730556
73positive regulation of gamma-delta T cell activation (GO:0046645)3.62954454
74positive regulation of interleukin-12 production (GO:0032735)3.60383671
75kynurenine metabolic process (GO:0070189)3.59823257
76detection of molecule of bacterial origin (GO:0032490)3.55960867
77regulation of immunoglobulin secretion (GO:0051023)3.53431755
78positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.53149030
79regulation of vitamin D biosynthetic process (GO:0060556)3.52420057
80regulation of response to interferon-gamma (GO:0060330)3.51992134
81B cell mediated immunity (GO:0019724)3.51409960
82positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.49740865
83positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.47700247
84indole-containing compound catabolic process (GO:0042436)3.44344258
85indolalkylamine catabolic process (GO:0046218)3.44344258
86tryptophan catabolic process (GO:0006569)3.44344258
87respiratory burst (GO:0045730)3.42384587
88response to dsRNA (GO:0043331)3.42272015
89regulation of T cell cytokine production (GO:0002724)3.42067696
90positive regulation of tolerance induction (GO:0002645)3.41235280
91response to muramyl dipeptide (GO:0032495)3.41022045
92positive regulation of T cell cytokine production (GO:0002726)3.40135895
93positive regulation of antigen processing and presentation (GO:0002579)3.40011015
94eosinophil migration (GO:0072677)3.39604480
95regulation of interleukin-17 production (GO:0032660)3.39457666
96positive regulation of NF-kappaB import into nucleus (GO:0042346)3.39388452
97positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.39232904
98regulation of interleukin-12 production (GO:0032655)3.38546781
99negative regulation of type 2 immune response (GO:0002829)3.38411659
100regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.38108736
101response to protozoan (GO:0001562)3.38033912
102regulation of antigen processing and presentation (GO:0002577)3.37579468
103microglial cell activation (GO:0001774)3.37154566
104interferon-gamma secretion (GO:0072643)3.36960473
105positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.36874937
106neutrophil activation (GO:0042119)3.36353962
107regulation of chronic inflammatory response (GO:0002676)3.36329370
108superoxide anion generation (GO:0042554)3.34234494
109myeloid dendritic cell differentiation (GO:0043011)3.32582084
110negative regulation of cytokine production involved in immune response (GO:0002719)3.32166549
111positive regulation of T-helper cell differentiation (GO:0045624)3.31866809
112regulation of defense response to virus by host (GO:0050691)3.31721410
113regulation of T-helper cell differentiation (GO:0045622)3.31581171
114cellular response to interferon-gamma (GO:0071346)3.29386118
115negative regulation of myeloid cell apoptotic process (GO:0033033)3.28528817
116antigen processing and presentation of endogenous antigen (GO:0019883)3.27689313
117JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.27049643
118regulation of type I interferon-mediated signaling pathway (GO:0060338)3.26276345
119reactive oxygen species biosynthetic process (GO:1903409)3.26128727
120regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.25719864
121myeloid cell activation involved in immune response (GO:0002275)3.24792654
122NIK/NF-kappaB signaling (GO:0038061)3.22487031
123* response to virus (GO:0009615)3.21397130
124* defense response to virus (GO:0051607)3.20408958
125positive regulation of defense response to virus by host (GO:0002230)3.18263351
126regulation of podosome assembly (GO:0071801)3.17810845
127regulation of interleukin-1 beta secretion (GO:0050706)3.14330754
128dendritic cell differentiation (GO:0097028)3.13234025
129regulation of dendritic cell antigen processing and presentation (GO:0002604)3.12930883
130positive regulation of mast cell degranulation (GO:0043306)3.12035510
131positive regulation of mast cell activation involved in immune response (GO:0033008)3.12035510
132negative regulation of viral process (GO:0048525)3.10897573
133antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.10659040
134antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.10659040
135regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.10338937
136regulation of interferon-beta production (GO:0032648)3.09743508
137regulation of heat generation (GO:0031650)3.08062480
138regulation of interleukin-8 biosynthetic process (GO:0045414)3.07933233
139negative regulation of type I interferon production (GO:0032480)3.07505260
140regulation of toll-like receptor signaling pathway (GO:0034121)3.07281794
141regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.06983125
142regulation of lymphocyte chemotaxis (GO:1901623)3.06361839
143cellular response to ethanol (GO:0071361)3.06023930
144JAK-STAT cascade (GO:0007259)3.05875561
145production of molecular mediator involved in inflammatory response (GO:0002532)3.04564370
146B cell proliferation (GO:0042100)3.04268387
147regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.03834333
148regulation of cytokine secretion involved in immune response (GO:0002739)3.03394602
149positive regulation of chemokine production (GO:0032722)3.03322337

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human8.86664558
2IRF8_21731497_ChIP-ChIP_J774_Mouse7.85798472
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human6.77599580
4BP1_19119308_ChIP-ChIP_Hs578T_Human6.51100324
5* IRF8_22096565_ChIP-ChIP_GC-B_Mouse5.28223514
6* IRF8_27001747_Chip-Seq_BMDM_Mouse4.45759279
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.90205347
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.62030090
9* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.47971377
10* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.44781442
11Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.99239348
12* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.83184857
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.83040123
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.73275852
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.49621147
16GATA1_22025678_ChIP-Seq_K562_Human2.42775705
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.42213222
18* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.37399682
19STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.25781115
20MYB_21317192_ChIP-Seq_ERMYB_Mouse2.25362874
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.76390497
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.74418134
23TP63_17297297_ChIP-ChIP_HaCaT_Human1.68982298
24PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.58103795
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.57524045
26THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.56952347
27CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.51279834
28SPI1_23547873_ChIP-Seq_NB4_Human1.50411357
29BRD4_27068464_Chip-Seq_AML-cells_Mouse1.49145535
30CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.49106067
31SMAD_19615063_ChIP-ChIP_OVARY_Human1.47812138
32PU_27001747_Chip-Seq_BMDM_Mouse1.45661909
33PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.42306745
34VDR_24787735_ChIP-Seq_THP-1_Human1.38466077
35MYB_26560356_Chip-Seq_TH2_Human1.32622375
36CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22235230
37TRIM28_21343339_ChIP-Seq_HEK293_Human1.22231927
38EGR1_19032775_ChIP-ChIP_M12_Human1.18568093
39PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17048824
40VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.14913881
41CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13370058
42GATA3_26560356_Chip-Seq_TH2_Human1.12854325
43MAF_26560356_Chip-Seq_TH1_Human1.09185945
44RUNX_20019798_ChIP-Seq_JUKART_Human1.08922615
45VDR_24763502_ChIP-Seq_THP-1_Human1.08053524
46GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05823964
47SOX2_20726797_ChIP-Seq_SW620_Human1.05387940
48RUNX1_22412390_ChIP-Seq_EML_Mouse1.04127223
49CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.02996033
50SPI1_23127762_ChIP-Seq_K562_Human1.02734519
51EGR1_23403033_ChIP-Seq_LIVER_Mouse1.01768859
52MYB_26560356_Chip-Seq_TH1_Human1.00813266
53FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.00719765
54GATA2_21666600_ChIP-Seq_HMVEC_Human0.97883462
55TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96666433
56PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96344867
57STAT1_20625510_ChIP-Seq_HELA_Human0.95947118
58RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.93783958
59ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.91988072
60IKZF1_21737484_ChIP-ChIP_HCT116_Human0.87731343
61GATA3_27048872_Chip-Seq_THYMUS_Human0.87093319
62NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.86854980
63CDX2_19796622_ChIP-Seq_MESCs_Mouse0.85504562
64SCL_19346495_ChIP-Seq_HPC-7_Human0.84850702
65SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83247031
66GATA2_22383799_ChIP-Seq_G1ME_Mouse0.82979371
67NRF2_20460467_ChIP-Seq_MEFs_Mouse0.81362307
68NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.81362307
69VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.80675914
70CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.80171290
71MAF_26560356_Chip-Seq_TH2_Human0.80017836
72ESR2_21235772_ChIP-Seq_MCF-7_Human0.76658746
73LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.76376452
74TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.72372352
75* RXR_22158963_ChIP-Seq_LIVER_Mouse0.71623219
76BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.69908249
77TFEB_21752829_ChIP-Seq_HELA_Human0.69428196
78TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.69229050
79GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.69044837
80FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.68982874
81VDR_21846776_ChIP-Seq_THP-1_Human0.68834660
82LXR_22158963_ChIP-Seq_LIVER_Mouse0.68138393
83CJUN_26792858_Chip-Seq_BT549_Human0.67658645
84PPARA_22158963_ChIP-Seq_LIVER_Mouse0.67257164
85NOTCH1_21737748_ChIP-Seq_TLL_Human0.66901580
86FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.65689629
87JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.65651099
88CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.65194715
89MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.64518785
90SALL4_18804426_ChIP-ChIP_XEN_Mouse0.64340012
91FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.64028364
92CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.62977103
93JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.61521142
94LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.60812835
95ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.60715264
96TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.59588706
97SMRT_27268052_Chip-Seq_Bcells_Human0.58954287
98GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.58693549
99GATA1_19941826_ChIP-Seq_K562_Human0.58315321
100KDM2B_26808549_Chip-Seq_SUP-B15_Human0.57982691
101SPI1_20517297_ChIP-Seq_HL60_Human0.57305586
102KDM2B_26808549_Chip-Seq_DND41_Human0.56546344
103ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.55707333
104GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.55580358
105ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.55464156
106CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.55267899
107UTX_26944678_Chip-Seq_JUKART_Human0.55092173
108E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.54257133
109PU.1_20513432_ChIP-Seq_Bcells_Mouse0.53319569
110SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.51324675
111BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.51290701
112P63_26484246_Chip-Seq_KERATINOCYTES_Human0.51171935
113* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.49866548
114SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.49799875
115SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.49799875
116GATA2_19941826_ChIP-Seq_K562_Human0.49735003
117GATA1_22383799_ChIP-Seq_G1ME_Mouse0.49050772
118CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.48813513
119ELK3_25401928_ChIP-Seq_HUVEC_Human0.48457749
120GATA1_19941827_ChIP-Seq_MEL_Mouse0.48334900
121TCF7_22412390_ChIP-Seq_EML_Mouse0.47545491
122BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.46682288
123PU1_27457419_Chip-Seq_LIVER_Mouse0.44892881
124MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.44860453

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009785_altered_susceptibility_to4.97585302
2MP0001835_abnormal_antigen_presentation4.44331708
3MP0003436_decreased_susceptibility_to4.00180638
4MP0003724_increased_susceptibility_to3.98183370
5* MP0002148_abnormal_hypersensitivity_rea3.95700017
6* MP0006082_CNS_inflammation3.85287293
7MP0003303_peritoneal_inflammation3.65519760
8* MP0005000_abnormal_immune_tolerance3.39444302
9* MP0005025_abnormal_response_to3.28672485
10MP0002419_abnormal_innate_immunity3.13392407
11MP0005387_immune_system_phenotype3.12188814
12MP0001790_abnormal_immune_system3.12188814
13MP0004510_myositis3.03554305
14MP0000685_abnormal_immune_system2.95997595
15MP0005671_abnormal_response_to2.67058844
16* MP0002723_abnormal_immune_serum2.57483392
17MP0009764_decreased_sensitivity_to2.55721776
18* MP0002452_abnormal_antigen_presenting2.52703660
19* MP0001800_abnormal_humoral_immune2.49031313
20MP0004947_skin_inflammation2.39393437
21MP0001533_abnormal_skeleton_physiology2.38715398
22* MP0001819_abnormal_immune_cell2.08689138
23MP0001853_heart_inflammation2.03308262
24MP0005058_abnormal_lysosome_morphology2.01106557
25* MP0002420_abnormal_adaptive_immunity2.00761456
26MP0001845_abnormal_inflammatory_respons1.94897714
27MP0002139_abnormal_hepatobiliary_system1.94591140
28* MP0008469_abnormal_protein_level1.90102749
29MP0003075_altered_response_to1.88233815
30MP0002006_tumorigenesis1.86343074
31MP0003448_altered_tumor_morphology1.83544611
32MP0010155_abnormal_intestine_physiology1.80434467
33MP0005464_abnormal_platelet_physiology1.78217305
34MP0005451_abnormal_body_composition1.75220298
35MP0005310_abnormal_salivary_gland1.69309604
36MP0009278_abnormal_bone_marrow1.66287847
37MP0000343_altered_response_to1.66005761
38MP0002405_respiratory_system_inflammati1.58993647
39MP0004858_abnormal_nervous_system1.54864327
40MP0005167_abnormal_blood-brain_barrier1.53769231
41MP0003690_abnormal_glial_cell1.47790228
42MP0003172_abnormal_lysosome_physiology1.47219668
43* MP0000716_abnormal_immune_system1.42120677
44MP0009840_abnormal_foam_cell1.40916453
45MP0000604_amyloidosis1.38525766
46MP0006054_spinal_hemorrhage1.37162571
47MP0003806_abnormal_nucleotide_metabolis1.36311867
48MP0002998_abnormal_bone_remodeling1.36110584
49MP0005164_abnormal_response_to1.34859243
50MP0005166_decreased_susceptibility_to1.32285863
51MP0002398_abnormal_bone_marrow1.32281439
52MP0001501_abnormal_sleep_pattern1.27826939
53MP0004782_abnormal_surfactant_physiolog1.27351601
54MP0001545_abnormal_hematopoietic_system1.26113633
55MP0005397_hematopoietic_system_phenotyp1.26113633
56MP0000858_altered_metastatic_potential1.23417813
57MP0009763_increased_sensitivity_to1.22121467
58MP0002277_abnormal_respiratory_mucosa1.20296708
59MP0002138_abnormal_hepatobiliary_system1.18156679
60MP0002254_reproductive_system_inflammat1.11160261
61MP0005390_skeleton_phenotype1.09924035
62MP0003191_abnormal_cellular_cholesterol1.09640181
63MP0003300_gastrointestinal_ulcer1.08029424
64MP0003221_abnormal_cardiomyocyte_apopto1.07375185
65* MP0002429_abnormal_blood_cell1.06867681
66MP0003186_abnormal_redox_activity1.06405508
67MP0002163_abnormal_gland_morphology1.04214390
68MP0002332_abnormal_exercise_endurance0.98703105
69MP0003195_calcinosis0.98631740
70MP0003453_abnormal_keratinocyte_physiol0.97776691
71MP0000689_abnormal_spleen_morphology0.97631529
72MP0010307_abnormal_tumor_latency0.95914057
73MP0002166_altered_tumor_susceptibility0.91971215
74MP0002722_abnormal_immune_system0.90549459
75MP0001851_eye_inflammation0.88834931
76MP0008874_decreased_physiological_sensi0.79211106
77MP0003828_pulmonary_edema0.77095864
78* MP0000920_abnormal_myelination0.75466470
79* MP0009333_abnormal_splenocyte_physiolog0.73275611
80MP0003045_fibrosis0.73255199
81MP0003091_abnormal_cell_migration0.72819948
82MP0009765_abnormal_xenobiotic_induced0.69681805
83MP0000569_abnormal_digit_pigmentation0.68522786
84MP0005379_endocrine/exocrine_gland_phen0.67898244
85MP0003763_abnormal_thymus_physiology0.67094709
86MP0005076_abnormal_cell_differentiation0.65848810
87MP0000249_abnormal_blood_vessel0.65500127
88MP0002933_joint_inflammation0.64597011
89MP0005083_abnormal_biliary_tract0.63795261
90MP0002136_abnormal_kidney_physiology0.61988916
91MP0010386_abnormal_urinary_bladder0.61866342
92MP0005165_increased_susceptibility_to0.61198983
93MP0001663_abnormal_digestive_system0.60788467
94MP0001873_stomach_inflammation0.59056658
95MP0003866_abnormal_defecation0.58925023
96MP0000609_abnormal_liver_physiology0.58271363
97MP0008438_abnormal_cutaneous_collagen0.58217553
98MP0010352_gastrointestinal_tract_polyps0.58160029
99MP0002877_abnormal_melanocyte_morpholog0.58116070
100MP0005535_abnormal_body_temperature0.57091734
101MP0003646_muscle_fatigue0.56915062
102MP0008004_abnormal_stomach_pH0.55465110
103MP0002693_abnormal_pancreas_physiology0.54078849
104MP0003566_abnormal_cell_adhesion0.53707622
105MP0003950_abnormal_plasma_membrane0.53196327
106MP0005584_abnormal_enzyme/coenzyme_acti0.49762188
107MP0004808_abnormal_hematopoietic_stem0.49408841
108MP0000703_abnormal_thymus_morphology0.49246088
109MP0003795_abnormal_bone_structure0.48315562
110MP0005023_abnormal_wound_healing0.48252798
111MP0005647_abnormal_sex_gland0.47511324
112MP0005319_abnormal_enzyme/_coenzyme0.47277336
113MP0004883_abnormal_blood_vessel0.45979313
114MP0001881_abnormal_mammary_gland0.45584264
115MP0001348_abnormal_lacrimal_gland0.45537943
116MP0003656_abnormal_erythrocyte_physiolo0.43860749
117MP0008260_abnormal_autophagy0.43666094
118MP0003329_amyloid_beta_deposits0.43383422
119MP0003183_abnormal_peptide_metabolism0.43158176

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)7.14425527
2Recurrent bacterial skin infections (HP:0005406)6.84789062
3Eczematoid dermatitis (HP:0000976)6.79997880
4Elevated erythrocyte sedimentation rate (HP:0003565)5.91114030
5Recurrent gram-negative bacterial infections (HP:0005420)5.84040406
6Autoimmune thrombocytopenia (HP:0001973)5.80128831
7Increased IgM level (HP:0003496)5.58453893
8Mediastinal lymphadenopathy (HP:0100721)5.55777337
9Systemic lupus erythematosus (HP:0002725)5.13892713
10Abnormality of macrophages (HP:0004311)4.99818500
11Stomatitis (HP:0010280)4.53173036
12Basal ganglia calcification (HP:0002135)4.44738486
13Orchitis (HP:0100796)4.43024461
14Vasculitis (HP:0002633)4.30163418
15Myositis (HP:0100614)4.18849492
16Gingivitis (HP:0000230)4.15763465
17Recurrent skin infections (HP:0001581)4.14913263
18Retrobulbar optic neuritis (HP:0100654)4.05726980
19Optic neuritis (HP:0100653)4.05726980
20Thick nail (HP:0001805)3.69104934
21Hypergammaglobulinemia (HP:0010702)3.66472201
22Interstitial pulmonary disease (HP:0006530)3.62628976
23Loss of speech (HP:0002371)3.60625987
24Porencephaly (HP:0002132)3.55605000
25Abnormality of T cell number (HP:0011839)3.55303566
26Cheilitis (HP:0100825)3.52743710
27Recurrent fungal infections (HP:0002841)3.50229048
28Tetraparesis (HP:0002273)3.40751174
29Periodontitis (HP:0000704)3.33689072
30Vacuolated lymphocytes (HP:0001922)3.32457783
31T lymphocytopenia (HP:0005403)3.28393298
32Pustule (HP:0200039)3.27798054
33Recurrent viral infections (HP:0004429)3.26217843
34Chronic obstructive pulmonary disease (HP:0006510)3.24092664
35Obstructive lung disease (HP:0006536)3.24092664
36Increased cerebral lipofuscin (HP:0011813)3.22834753
37Increased neuronal autofluorescent lipopigment (HP:0002074)3.19425109
38Prostate neoplasm (HP:0100787)3.12277875
39Chronic otitis media (HP:0000389)3.10830143
40Poor head control (HP:0002421)3.03418684
41Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.00978426
42Autoimmune hemolytic anemia (HP:0001890)2.97479219
43Pulmonary infiltrates (HP:0002113)2.94091841
44Gastrointestinal infarctions (HP:0005244)2.89712876
45Urticaria (HP:0001025)2.86926965
46Dysostosis multiplex (HP:0000943)2.85295771
47Axonal loss (HP:0003447)2.82785049
48Premature loss of primary teeth (HP:0006323)2.80588647
49Abnormality of the endocardium (HP:0004306)2.80062757
50Abnormality of the pericardium (HP:0001697)2.77369984
51Cellulitis (HP:0100658)2.75373251
52Recurrent cutaneous fungal infections (HP:0011370)2.69790131
53Chronic mucocutaneous candidiasis (HP:0002728)2.69790131
54Encephalitis (HP:0002383)2.66830092
55Abnormality of B cell number (HP:0010975)2.66559430
56Disinhibition (HP:0000734)2.65881728
57Abnormal delayed hypersensitivity skin test (HP:0002963)2.64088746
58Recurrent pneumonia (HP:0006532)2.59763150
59Cleft eyelid (HP:0000625)2.59640212
60Glomerulonephritis (HP:0000099)2.59155500
61Petechiae (HP:0000967)2.58642270
62Purpura (HP:0000979)2.56149334
63Nephritis (HP:0000123)2.55882274
64Osteolytic defects of the phalanges of the hand (HP:0009771)2.45200016
65Osteolytic defects of the hand bones (HP:0009699)2.45200016
66Joint swelling (HP:0001386)2.43347742
67Lower limb hyperreflexia (HP:0002395)2.40540525
68Recurrent lower respiratory tract infections (HP:0002783)2.39932863
69Leukocytosis (HP:0001974)2.39881245
70Abnormality of the pleura (HP:0002103)2.39724238
71Prolonged neonatal jaundice (HP:0006579)2.39021300
72Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.38347134
73Abnormality of liposaccharide metabolism (HP:0010968)2.37113783
74Abnormality of glycosphingolipid metabolism (HP:0004343)2.37113783
75Abnormality of glycolipid metabolism (HP:0010969)2.37113783
76Hepatosplenomegaly (HP:0001433)2.36917783
77Hemoptysis (HP:0002105)2.34321772
78Hemorrhage of the eye (HP:0011885)2.34107503
79Nausea (HP:0002018)2.33661934
80Complement deficiency (HP:0004431)2.31270009
81Keratoconjunctivitis sicca (HP:0001097)2.29225730
82Anorexia (HP:0002039)2.28502695
83Gingival bleeding (HP:0000225)2.28362651
84Pulmonary embolism (HP:0002204)2.28201551
85Keratoconjunctivitis (HP:0001096)2.28180407
86Arterial thrombosis (HP:0004420)2.28063620
87B lymphocytopenia (HP:0010976)2.28042269
88Abnormality of polysaccharide metabolism (HP:0011012)2.27939402
89Abnormality of glycosaminoglycan metabolism (HP:0004371)2.27939402
90Abnormality of mucopolysaccharide metabolism (HP:0011020)2.27939402
91Parakeratosis (HP:0001036)2.27086615
92Nasal polyposis (HP:0100582)2.26983739
93Peritonitis (HP:0002586)2.25090262
94Meningitis (HP:0001287)2.24336224
95Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.23930509
96Polyneuropathy (HP:0001271)2.23361180
97Vertigo (HP:0002321)2.23077394
98Amyloidosis (HP:0011034)2.21752907
99Mutism (HP:0002300)2.20487253
100Progressive neurologic deterioration (HP:0002344)2.18584065
101Progressive visual loss (HP:0000529)2.18117682
102Malnutrition (HP:0004395)2.17160207
103Urinary glycosaminoglycan excretion (HP:0003541)2.16275653
104Mucopolysacchariduria (HP:0008155)2.16275653
105Esophageal neoplasm (HP:0100751)2.15148800
106Neoplasm of head and neck (HP:0012288)2.15148800
107Colitis (HP:0002583)2.14586353
108Arthralgia (HP:0002829)2.13957806
109Osteomyelitis (HP:0002754)2.12456846
110Hematochezia (HP:0002573)2.10608112
111Bone pain (HP:0002653)2.09693428
112Memory impairment (HP:0002354)2.08025863
113Glomerulopathy (HP:0100820)2.07898780
114Stomach cancer (HP:0012126)2.07822601
115Pigmentary retinal degeneration (HP:0001146)2.06925661
116Gangrene (HP:0100758)2.06566514
117Amaurosis fugax (HP:0100576)2.05373695
118Abnormality of T cells (HP:0002843)2.04276340
119Keratitis (HP:0000491)2.04098589
120Chest pain (HP:0100749)2.04029703
121Myocardial infarction (HP:0001658)2.03942340
122Abnormality of the nasal mucosa (HP:0000433)2.03131781
123Eosinophilia (HP:0001880)2.01402033
124Skin ulcer (HP:0200042)2.00640272
125Plagiocephaly (HP:0001357)2.00552812
126Abnormality of the basal ganglia (HP:0002134)1.97036797
127Abnormality of the prostate (HP:0008775)1.96590749
128Skin rash (HP:0000988)1.95742670
129IgA deficiency (HP:0002720)1.95190178
130Neurofibrillary tangles (HP:0002185)1.95100973
131Albinism (HP:0001022)1.94846083
132Vertebral compression fractures (HP:0002953)1.93399199
133Recurrent bronchitis (HP:0002837)1.93232238
134Pathologic fracture (HP:0002756)1.92696943
135Spastic tetraparesis (HP:0001285)1.90860295
136Increased serum ferritin (HP:0003281)1.90709172

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K144.73619158
2PBK4.58001915
3TBK14.15934051
4TYK23.88053406
5RIPK43.82541545
6BLK3.52166147
7IKBKE3.44451133
8IRAK43.35753343
9IRAK32.88903774
10JAK32.79395779
11PIM22.56003195
12JAK12.53955996
13ERN12.43248496
14TXK2.43187364
15IKBKB2.39132870
16MAP3K132.32141302
17PRPF4B1.79657294
18KIT1.78852122
19MAP4K11.77448155
20CSK1.65285591
21BMPR21.59210293
22MATK1.51551782
23FGFR41.51528813
24BMX1.48545521
25CHUK1.46363986
26FGR1.44643297
27TAOK21.37074473
28MAP3K51.35232477
29IRAK11.32309727
30MST41.31865456
31NEK91.29908038
32SYK1.28523648
33RPS6KA41.26204074
34ZAP701.24341160
35HCK1.21302117
36ARAF1.20643958
37EPHA31.14808819
38EIF2AK21.13489163
39SIK31.12109582
40IRAK21.10439075
41MARK31.09524133
42EPHB11.08591997
43JAK21.04525631
44ABL21.02895162
45LYN1.01220347
46CDC42BPA0.95175583
47PIM10.92991598
48FGFR30.90891723
49SIK20.87694266
50LCK0.84928553
51STK40.79441823
52MAP3K30.74233713
53PRKCD0.72030181
54MST1R0.71188244
55TNK20.66224875
56ERBB30.65726700
57HIPK20.64862860
58TAOK10.62796020
59TGFBR20.60878587
60GRK70.60774466
61ABL10.60561866
62TYRO30.60490565
63ADRBK20.58978949
64PLK20.58636410
65NME20.58436059
66CSF1R0.56903839
67EGFR0.53450112
68DAPK30.53300317
69BTK0.52861042
70TESK20.51958316
71YES10.51323438
72TESK10.49813575
73PRKCQ0.49328903
74STK30.49052106
75FES0.43586291
76MOS0.40746796
77BCR0.39036897
78ERBB40.38725034
79TRPM70.38365346
80CLK10.38312508
81TAOK30.37447448
82STK100.36599436
83MAP3K120.34941484
84RIPK10.34066030
85CAMK2G0.33823865
86PLK40.32362836
87CDK40.31892585
88ITK0.30395841
89KSR20.30312794
90MAP3K10.29824762
91TEC0.29657451
92PDGFRA0.28454178
93MAP3K90.28138874
94LATS20.27804920
95FYN0.27083651
96MAPK70.25969692
97SIK10.25743370
98DYRK30.25702945
99MAPKAPK20.22965624
100MAP2K30.22953517
101RPS6KA50.22902372
102DDR20.21580089
103STK240.20011027
104DAPK20.19008223
105PDPK10.18602318
106DYRK1B0.17816238
107IGF1R0.17182777
108SRC0.16094245
109BMPR1B0.15146838
110PKN10.15096968
111MAP3K110.14511167
112PDK10.13983387
113PRKCE0.13871859
114INSR0.13718393
115NLK0.13625709
116LRRK20.13199249
117MAPK110.12204928
118CAMKK20.11947546
119MAPK30.11798490
120ACVR1B0.11367009
121RPS6KA10.09839793
122MELK0.09656273
123MAPK40.09291953
124CDK60.08329663
125PDGFRB0.04388992

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053324.17418504
2Allograft rejection_Homo sapiens_hsa053303.55720409
3Leishmaniasis_Homo sapiens_hsa051403.31366474
4* Toll-like receptor signaling pathway_Homo sapiens_hsa046203.11930820
5* Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.07585254
6Staphylococcus aureus infection_Homo sapiens_hsa051502.87136508
7Asthma_Homo sapiens_hsa053102.78719121
8Type I diabetes mellitus_Homo sapiens_hsa049402.73582039
9Legionellosis_Homo sapiens_hsa051342.66716735
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.63986759
11* RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.60308171
12NOD-like receptor signaling pathway_Homo sapiens_hsa046212.58274101
13Malaria_Homo sapiens_hsa051442.56317958
14Rheumatoid arthritis_Homo sapiens_hsa053232.48916026
15Pertussis_Homo sapiens_hsa051332.47787347
16African trypanosomiasis_Homo sapiens_hsa051432.45725007
17Intestinal immune network for IgA production_Homo sapiens_hsa046722.36153799
18Measles_Homo sapiens_hsa051622.30772762
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.28032510
20* Influenza A_Homo sapiens_hsa051642.21522099
21Tuberculosis_Homo sapiens_hsa051522.06338967
22* TNF signaling pathway_Homo sapiens_hsa046682.04862496
23Osteoclast differentiation_Homo sapiens_hsa043802.04393462
24Herpes simplex infection_Homo sapiens_hsa051681.91796146
25Salmonella infection_Homo sapiens_hsa051321.83643046
26Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.62838479
27Autoimmune thyroid disease_Homo sapiens_hsa053201.59415912
28Toxoplasmosis_Homo sapiens_hsa051451.55415108
29* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.46700825
30Hepatitis C_Homo sapiens_hsa051601.27999487
31Hematopoietic cell lineage_Homo sapiens_hsa046401.26496244
32Jak-STAT signaling pathway_Homo sapiens_hsa046301.25512876
33Phagosome_Homo sapiens_hsa041451.23887547
34Prion diseases_Homo sapiens_hsa050201.19805251
35Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.19482415
36* Chemokine signaling pathway_Homo sapiens_hsa040621.17696927
37Antigen processing and presentation_Homo sapiens_hsa046121.15593914
38Lysosome_Homo sapiens_hsa041421.14480068
39Apoptosis_Homo sapiens_hsa042101.13395532
40Hepatitis B_Homo sapiens_hsa051611.10483036
41Viral myocarditis_Homo sapiens_hsa054161.09176285
42Amoebiasis_Homo sapiens_hsa051461.03196230
43AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.98215121
44Shigellosis_Homo sapiens_hsa051310.98132678
45B cell receptor signaling pathway_Homo sapiens_hsa046620.92756066
46Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.90183645
47Primary immunodeficiency_Homo sapiens_hsa053400.80371239
48Tryptophan metabolism_Homo sapiens_hsa003800.74351693
49Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.73203597
50Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.72364902
51Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.67698052
52Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63507925
53Adipocytokine signaling pathway_Homo sapiens_hsa049200.59319215
54Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55723933
55Glycosaminoglycan degradation_Homo sapiens_hsa005310.54628436
56Prolactin signaling pathway_Homo sapiens_hsa049170.54442803
57Type II diabetes mellitus_Homo sapiens_hsa049300.49630779
58T cell receptor signaling pathway_Homo sapiens_hsa046600.47479882
59Complement and coagulation cascades_Homo sapiens_hsa046100.47080626
60Leukocyte transendothelial migration_Homo sapiens_hsa046700.44720886
61Collecting duct acid secretion_Homo sapiens_hsa049660.43706756
62Sphingolipid metabolism_Homo sapiens_hsa006000.41839947
63SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38044486
64HIF-1 signaling pathway_Homo sapiens_hsa040660.37690639
65Epstein-Barr virus infection_Homo sapiens_hsa051690.37595637
66Other glycan degradation_Homo sapiens_hsa005110.36213551
67Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.35679748
68Sulfur metabolism_Homo sapiens_hsa009200.35667384
69Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35431935
70Bladder cancer_Homo sapiens_hsa052190.34766979
71Acute myeloid leukemia_Homo sapiens_hsa052210.34390636
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.34123956
73Mineral absorption_Homo sapiens_hsa049780.32712076
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.30422589
75Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.30254844
76Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.28384203
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.27574206
78Platelet activation_Homo sapiens_hsa046110.26091474
79Small cell lung cancer_Homo sapiens_hsa052220.26020591
80Chronic myeloid leukemia_Homo sapiens_hsa052200.25802045
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.25194788
82Dorso-ventral axis formation_Homo sapiens_hsa043200.23738467
83Viral carcinogenesis_Homo sapiens_hsa052030.20228331
84Primary bile acid biosynthesis_Homo sapiens_hsa001200.19592221
85Pancreatic cancer_Homo sapiens_hsa052120.19097349
86Proteasome_Homo sapiens_hsa030500.17833973
87HTLV-I infection_Homo sapiens_hsa051660.17479798
88Insulin resistance_Homo sapiens_hsa049310.15070162
89Notch signaling pathway_Homo sapiens_hsa043300.14819241
90Pentose and glucuronate interconversions_Homo sapiens_hsa000400.13842718
91Transcriptional misregulation in cancer_Homo sapiens_hsa052020.12969258
92Proteoglycans in cancer_Homo sapiens_hsa052050.12940407
93Folate biosynthesis_Homo sapiens_hsa007900.11886391
94Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.09466005
95Arginine biosynthesis_Homo sapiens_hsa002200.09444579
96Caffeine metabolism_Homo sapiens_hsa002320.06965472
97FoxO signaling pathway_Homo sapiens_hsa040680.06148365
98MAPK signaling pathway_Homo sapiens_hsa040100.04659178
99Systemic lupus erythematosus_Homo sapiens_hsa053220.04461035
100VEGF signaling pathway_Homo sapiens_hsa043700.04334764
101Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.04263550
102Regulation of actin cytoskeleton_Homo sapiens_hsa048100.03098600
103PPAR signaling pathway_Homo sapiens_hsa033200.02033521
104Vibrio cholerae infection_Homo sapiens_hsa051100.01938535
105Renal cell carcinoma_Homo sapiens_hsa05211-0.0738190
106Fatty acid biosynthesis_Homo sapiens_hsa00061-0.0705240
107Drug metabolism - other enzymes_Homo sapiens_hsa00983-0.0399039
108Endocytosis_Homo sapiens_hsa04144-0.0272856
109Regulation of autophagy_Homo sapiens_hsa04140-0.0169355
110Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0161092

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