CXCL12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This antimicrobial gene encodes a stromal cell-derived alpha chemokine member of the intercrine family. The encoded protein functions as the ligand for the G-protein coupled receptor, chemokine (C-X-C motif) receptor 4, and plays a role in many diverse cellular functions, including embryogenesis, immune surveillance, inflammation response, tissue homeostasis, and tumor growth and metastasis. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of norepinephrine secretion (GO:0010700)9.13605153
2regulation of gonadotropin secretion (GO:0032276)8.63328395
3phenylpropanoid metabolic process (GO:0009698)7.87939832
4glucocorticoid biosynthetic process (GO:0006704)7.74943741
5positive regulation of digestive system process (GO:0060456)7.25192039
6parturition (GO:0007567)6.99968549
7locomotory exploration behavior (GO:0035641)6.88650828
8positive regulation of odontogenesis (GO:0042482)6.85054475
9positive regulation of steroid hormone secretion (GO:2000833)6.79642767
10tooth mineralization (GO:0034505)6.78608890
11regulation of glucocorticoid secretion (GO:2000849)6.69117750
12regulation of corticosteroid hormone secretion (GO:2000846)6.55872046
13regulation of odontogenesis of dentin-containing tooth (GO:0042487)5.79457433
14negative regulation of catecholamine secretion (GO:0033604)5.72257281
15* positive regulation of calcium ion import (GO:0090280)5.62740694
16positive regulation of macrophage derived foam cell differentiation (GO:0010744)5.44767209
17regulation of monocyte differentiation (GO:0045655)5.31486196
18cellular response to dexamethasone stimulus (GO:0071549)5.11218469
19L-phenylalanine catabolic process (GO:0006559)4.92827329
20erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.92827329
21negative regulation of fibrinolysis (GO:0051918)4.84420978
22peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)4.83808783
23hypothalamus development (GO:0021854)4.82558403
24protein carboxylation (GO:0018214)4.79974081
25peptidyl-glutamic acid carboxylation (GO:0017187)4.79974081
26L-phenylalanine metabolic process (GO:0006558)4.78227402
27erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.78227402
28response to dexamethasone (GO:0071548)4.74660984
29negative regulation of circadian rhythm (GO:0042754)4.74068685
30RNA destabilization (GO:0050779)4.74068385
31synaptic transmission, dopaminergic (GO:0001963)4.72795709
32epoxygenase P450 pathway (GO:0019373)4.66178747
33regulation of steroid hormone secretion (GO:2000831)4.62556721
34ether metabolic process (GO:0018904)4.57693826
35glucocorticoid metabolic process (GO:0008211)4.54126290
36regulation of norepinephrine secretion (GO:0014061)4.52549149
37regulation of fibrinolysis (GO:0051917)4.46600058
38aromatic amino acid family catabolic process (GO:0009074)4.34163043
39somite development (GO:0061053)4.29366695
40positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003574.27402789
41regulation of protein activation cascade (GO:2000257)4.24958178
42convergent extension (GO:0060026)4.23894541
43protein heterotrimerization (GO:0070208)4.23673486
44triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.20391417
45alpha-linolenic acid metabolic process (GO:0036109)4.18875979
46circadian sleep/wake cycle process (GO:0022410)4.18162148
47adrenal gland development (GO:0030325)4.14359343
48regulation of complement activation (GO:0030449)4.09681065
49glyoxylate metabolic process (GO:0046487)4.05171342
50complement activation, alternative pathway (GO:0006957)3.94115825
51kynurenine metabolic process (GO:0070189)3.93362935
52vascular endothelial growth factor signaling pathway (GO:0038084)3.92815443
53bile acid biosynthetic process (GO:0006699)3.90903565
54homocysteine metabolic process (GO:0050667)3.82377393
55regulation of circadian sleep/wake cycle (GO:0042749)3.82081556
56regulation of circadian sleep/wake cycle, sleep (GO:0045187)3.82081556
57indole-containing compound catabolic process (GO:0042436)3.81878995
58indolalkylamine catabolic process (GO:0046218)3.81878995
59tryptophan catabolic process (GO:0006569)3.81878995
60glutathione biosynthetic process (GO:0006750)3.76662904
61cellular response to ammonium ion (GO:0071242)3.75957073
62lysine catabolic process (GO:0006554)3.75686224
63lysine metabolic process (GO:0006553)3.75686224
64response to corticosterone (GO:0051412)3.73010916
65positive regulation of fatty acid beta-oxidation (GO:0032000)3.69143387
66positive regulation of circadian rhythm (GO:0042753)3.68544014
67sulfur amino acid catabolic process (GO:0000098)3.64997785
68tryptophan metabolic process (GO:0006568)3.60417096
69exploration behavior (GO:0035640)3.55563673
70fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.53128222
71response to mineralocorticoid (GO:0051385)3.52649673
72nonribosomal peptide biosynthetic process (GO:0019184)3.51923919
73L-serine transport (GO:0015825)3.51505014
74fibrinolysis (GO:0042730)3.49896024
75toxin metabolic process (GO:0009404)3.48750845
76negative regulation of gluconeogenesis (GO:0045721)3.47601876
77cysteine metabolic process (GO:0006534)3.43824859
78high-density lipoprotein particle remodeling (GO:0034375)3.42408319
79* regulation of calcium ion import (GO:0090279)3.39418541
80regulation of triglyceride catabolic process (GO:0010896)3.38009683
81urea metabolic process (GO:0019627)3.37671538
82urea cycle (GO:0000050)3.37671538
83collagen fibril organization (GO:0030199)3.37479210
84regulation of plasminogen activation (GO:0010755)3.35498141
85positive regulation of macrophage differentiation (GO:0045651)3.33535385
86amino-acid betaine metabolic process (GO:0006577)3.33344702
87negative regulation of cartilage development (GO:0061037)3.30380795
88cellular response to ketone (GO:1901655)3.29197484
89positive regulation of fatty acid oxidation (GO:0046321)3.28368096
90plasma lipoprotein particle clearance (GO:0034381)3.25698032
91retina vasculature morphogenesis in camera-type eye (GO:0061299)3.24845303
92bile acid metabolic process (GO:0008206)3.24064817
93regulation of cholesterol homeostasis (GO:2000188)3.22867285
94circadian behavior (GO:0048512)3.19358463
95cochlea morphogenesis (GO:0090103)3.18336374
96barbed-end actin filament capping (GO:0051016)3.17776446
97regulation of macrophage derived foam cell differentiation (GO:0010743)3.16526261
98triglyceride homeostasis (GO:0070328)3.16079136
99acylglycerol homeostasis (GO:0055090)3.16079136
100regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.12176740
101nitrogen cycle metabolic process (GO:0071941)3.12116494
102response to gravity (GO:0009629)3.11410022
103positive regulation of lipid catabolic process (GO:0050996)3.10147571
104regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.09594073
105negative regulation of protein activation cascade (GO:2000258)3.08887995
106regulation of fatty acid beta-oxidation (GO:0031998)3.08228664
107negative regulation of translation, ncRNA-mediated (GO:0040033)3.06925151
108regulation of translation, ncRNA-mediated (GO:0045974)3.06925151
109negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.06925151
110keratan sulfate catabolic process (GO:0042340)3.04819692
111serine family amino acid catabolic process (GO:0009071)3.04641041
112reverse cholesterol transport (GO:0043691)3.03317913
113cellular ketone body metabolic process (GO:0046950)3.02516386
114tyrosine metabolic process (GO:0006570)3.02069345
115omega-hydroxylase P450 pathway (GO:0097267)3.01873126
116alpha-amino acid catabolic process (GO:1901606)2.99897516
117aromatic amino acid family metabolic process (GO:0009072)2.99880138
118chronic inflammatory response (GO:0002544)2.97859219
119extracellular matrix assembly (GO:0085029)2.97130449
120regulation of mononuclear cell migration (GO:0071675)2.96394782
121negative regulation of amine transport (GO:0051953)2.96324342
122opsonization (GO:0008228)2.94891153
123protein-lipid complex remodeling (GO:0034368)2.93894140
124macromolecular complex remodeling (GO:0034367)2.93894140
125plasma lipoprotein particle remodeling (GO:0034369)2.93894140
126serine transport (GO:0032329)2.93046277
127rhythmic behavior (GO:0007622)2.92920203
128virion attachment to host cell (GO:0019062)2.92695941
129adhesion of symbiont to host cell (GO:0044650)2.92695941
130skin morphogenesis (GO:0043589)2.91244014
131fatty acid beta-oxidation (GO:0006635)2.90004331
1322-oxoglutarate metabolic process (GO:0006103)2.89399184
133cellular modified amino acid catabolic process (GO:0042219)2.89247650
134coenzyme catabolic process (GO:0009109)2.89182288
135cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.88591840
136chondrocyte proliferation (GO:0035988)2.85815208
137cellular glucuronidation (GO:0052695)2.85667345
138negative regulation of cholesterol transport (GO:0032375)2.85439579
139negative regulation of sterol transport (GO:0032372)2.85439579
140glutamate metabolic process (GO:0006536)2.85059737
141regulation of sequestering of triglyceride (GO:0010889)2.84009085
142extracellular fibril organization (GO:0043206)2.83832614
143regulation of cholesterol esterification (GO:0010872)2.82665989
144negative regulation of blood coagulation (GO:0030195)2.81680463
145negative regulation of hemostasis (GO:1900047)2.81680463
146leukotriene biosynthetic process (GO:0019370)2.81468300
147fatty acid oxidation (GO:0019395)2.81396488
148dicarboxylic acid biosynthetic process (GO:0043650)2.80920255
149cell proliferation involved in kidney development (GO:0072111)2.80825872
1503-UTR-mediated mRNA stabilization (GO:0070935)2.80670726
151embryonic process involved in female pregnancy (GO:0060136)2.79161886
152ethanol oxidation (GO:0006069)2.79014051
153cell proliferation involved in metanephros development (GO:0072203)2.78993122
154metanephric mesenchyme development (GO:0072075)2.78812415
155venous blood vessel morphogenesis (GO:0048845)2.78164532
156regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.78029502
157cellular amino acid catabolic process (GO:0009063)2.77857083
158negative regulation of lipase activity (GO:0060192)2.77694088
159cell migration involved in heart development (GO:0060973)2.75497526
160bile acid and bile salt transport (GO:0015721)2.75290319
161acetyl-CoA metabolic process (GO:0006084)2.75226052
162kidney mesenchyme development (GO:0072074)2.75209954
163regulation of non-canonical Wnt signaling pathway (GO:2000050)2.74822062
164lipid oxidation (GO:0034440)2.74457051
165midgut development (GO:0007494)2.72808302
166phospholipid efflux (GO:0033700)2.70610741
167aspartate family amino acid catabolic process (GO:0009068)2.70455755
168positive regulation of hemostasis (GO:1900048)2.70321975
169positive regulation of blood coagulation (GO:0030194)2.70321975
170fatty acid transmembrane transport (GO:1902001)2.69303025
171positive regulation of endothelial cell apoptotic process (GO:2000353)2.69027307
172response to mercury ion (GO:0046689)2.68499706
173lymph vessel development (GO:0001945)2.68401080
174negative regulation of endothelial cell apoptotic process (GO:2000352)2.68017889
175carnitine metabolic process (GO:0009437)2.67294152
176short-chain fatty acid metabolic process (GO:0046459)2.65898940
177basement membrane organization (GO:0071711)2.65871786
178fatty acid catabolic process (GO:0009062)2.65797661
179peptide biosynthetic process (GO:0043043)2.64596222
180regulation of odontogenesis (GO:0042481)2.63754908
181type B pancreatic cell proliferation (GO:0044342)2.62682908
182negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.60804472
183maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.59928994
184vasculature development (GO:0001944)2.56726519
185protein retention in ER lumen (GO:0006621)2.56052611
186regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.55484215
187sequestering of extracellular ligand from receptor (GO:0035581)2.55291090

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.30543759
2* RXR_22158963_ChIP-Seq_LIVER_Mouse5.17405080
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.66504652
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.39668819
5* LXR_22158963_ChIP-Seq_LIVER_Mouse4.36277509
6TRIM28_21343339_ChIP-Seq_HEK293_Human3.77198221
7EGR1_23403033_ChIP-Seq_LIVER_Mouse3.34160172
8RARG_19884340_ChIP-ChIP_MEFs_Mouse3.30828202
9* CLOCK_20551151_ChIP-Seq_293T_Human3.26239761
10EGR1_19374776_ChIP-ChIP_THP-1_Human3.15491906
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.06468070
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.01771220
13PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.66110063
14TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.26106667
15TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.18069644
16TP63_17297297_ChIP-ChIP_HaCaT_Human2.17375885
17CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.14299013
18* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.07112749
19KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.06753876
20KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.06753876
21KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.06753876
22TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.97864615
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.95936681
24* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.87137805
25* EP300_21415370_ChIP-Seq_HL-1_Mouse1.82315708
26STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.79562044
27STAT6_21828071_ChIP-Seq_BEAS2B_Human1.72530085
28ESR2_21235772_ChIP-Seq_MCF-7_Human1.70556754
29SA1_22415368_ChIP-Seq_MEFs_Mouse1.67116628
30ESR1_21235772_ChIP-Seq_MCF-7_Human1.65091209
31NRF2_20460467_ChIP-Seq_MEFs_Mouse1.64859998
32NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.64859998
33* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.59422596
34* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.58417020
35THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.57071352
36* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.56859759
37CJUN_26792858_Chip-Seq_BT549_Human1.53278809
38* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.52227764
39ESR1_20079471_ChIP-ChIP_T-47D_Human1.50167321
40SMAD_19615063_ChIP-ChIP_OVARY_Human1.49105443
41ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.48955139
42FOXA2_19822575_ChIP-Seq_HepG2_Human1.47279083
43STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.42112527
44GATA2_21666600_ChIP-Seq_HMVEC_Human1.37016531
45* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.36923087
46BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.34298016
47* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.34200387
48TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.33041879
49CDX2_19796622_ChIP-Seq_MESCs_Mouse1.30081038
50GATA1_22025678_ChIP-Seq_K562_Human1.30044546
51TBX20_22328084_ChIP-Seq_HEART_Mouse1.29601181
52TBX20_22080862_ChIP-Seq_HEART_Mouse1.29601181
53WT1_19549856_ChIP-ChIP_CCG9911_Human1.24377777
54CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.23700331
55SALL4_18804426_ChIP-ChIP_XEN_Mouse1.23362363
56P63_26484246_Chip-Seq_KERATINOCYTES_Human1.20488261
57WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.20460789
58FOXO3_23340844_ChIP-Seq_DLD1_Human1.16744357
59* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.16396756
60DNAJC2_21179169_ChIP-ChIP_NT2_Human1.14303805
61* EED_16625203_ChIP-ChIP_MESCs_Mouse1.09264308
62ESR1_15608294_ChIP-ChIP_MCF-7_Human1.07344352
63* RAD21_21589869_ChIP-Seq_MESCs_Mouse1.06333994
64* KDM2B_26808549_Chip-Seq_K562_Human1.05618387
65PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.05288178
66HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.05164484
67SOX9_24532713_ChIP-Seq_HFSC_Mouse1.03197973
68ELK3_25401928_ChIP-Seq_HUVEC_Human1.03028420
69BRD4_25478319_ChIP-Seq_HGPS_Human1.02724402
70ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.02490204
71* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01552105
72SOX2_20726797_ChIP-Seq_SW620_Human1.00472342
73* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.00247803
74* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.00078420
75IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.97830160
76ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97393831
77ELK4_26923725_Chip-Seq_MESODERM_Mouse0.96790290
78* SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.94847283
79* RNF2_18974828_ChIP-Seq_MESCs_Mouse0.93829338
80* EZH2_18974828_ChIP-Seq_MESCs_Mouse0.93829338
81ZFP281_18757296_ChIP-ChIP_E14_Mouse0.93373676
82TP53_18474530_ChIP-ChIP_U2OS_Human0.93258278
83PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.93174348
84* PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.91926095
85* SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.91619330
86HIF1A_21447827_ChIP-Seq_MCF-7_Human0.90570890
87LXR_22292898_ChIP-Seq_THP-1_Human0.89129281
88* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.88702511
89HNF4A_19822575_ChIP-Seq_HepG2_Human0.88556028
90RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.88554093
91P300_27058665_Chip-Seq_ZR-75-30cells_Human0.87778665
92CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.86790352
93ISL1_27105846_Chip-Seq_CPCs_Mouse0.86625364
94UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.84635377
95SMC1_22415368_ChIP-Seq_MEFs_Mouse0.83753485
96* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.83207158
97MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.82713432
98SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.82267801
99RNF2_27304074_Chip-Seq_ESCs_Mouse0.81906988
100PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.81004286
101TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.80860472
102* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.79996992
103* RACK7_27058665_Chip-Seq_MCF-7_Human0.78872302
104AR_21572438_ChIP-Seq_LNCaP_Human0.78844336
105NFIB_24661679_ChIP-Seq_LUNG_Mouse0.78708750
106* SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.78153358
107TP53_20018659_ChIP-ChIP_R1E_Mouse0.77727318
108KDM2B_26808549_Chip-Seq_SUP-B15_Human0.77232864
109* RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.77014793
110ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.76786226
111CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.76554680
112JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.76496154
113SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.76410132
114JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.76154583
115* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.76067850
116STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.75281670
117MYB_21317192_ChIP-Seq_ERMYB_Mouse0.75160733
118* JARID2_20064375_ChIP-Seq_MESCs_Mouse0.75121259
119TP53_23651856_ChIP-Seq_MEFs_Mouse0.74855964
120SOX2_27498859_Chip-Seq_STOMACH_Mouse0.74478710
121GATA1_19941826_ChIP-Seq_K562_Human0.74453006
122* PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human0.74323708
123SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.73888067
124SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.73888067
125SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.73814790
126SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.73425543
127KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.73361355
128PIAS1_25552417_ChIP-Seq_VCAP_Human0.72676684
129RXR_22108803_ChIP-Seq_LS180_Human0.71922407
130TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.71698764
131KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.71176884
132SMC3_22415368_ChIP-Seq_MEFs_Mouse0.70114974
133GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.69468167
134ZNF263_19887448_ChIP-Seq_K562_Human0.69226828

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.36414028
2MP0002139_abnormal_hepatobiliary_system4.51598121
3MP0005360_urolithiasis4.43188077
4MP0003705_abnormal_hypodermis_morpholog3.92317216
5MP0004782_abnormal_surfactant_physiolog3.65665481
6MP0005085_abnormal_gallbladder_physiolo3.65642073
7MP0005365_abnormal_bile_salt3.50865388
8MP0005503_abnormal_tendon_morphology3.17179277
9MP0005275_abnormal_skin_tensile3.16560019
10MP0003279_aneurysm3.06594155
11MP0004272_abnormal_basement_membrane2.82817553
12MP0003252_abnormal_bile_duct2.80544209
13MP0003329_amyloid_beta_deposits2.70457594
14MP0008875_abnormal_xenobiotic_pharmacok2.63783112
15MP0010368_abnormal_lymphatic_system2.41220256
16MP0009384_cardiac_valve_regurgitation2.29960410
17MP0010329_abnormal_lipoprotein_level2.20321578
18MP0001958_emphysema2.15224064
19MP0004858_abnormal_nervous_system2.01829761
20MP0002933_joint_inflammation1.98251830
21MP0006054_spinal_hemorrhage1.89032554
22MP0003191_abnormal_cellular_cholesterol1.87101662
23MP0003806_abnormal_nucleotide_metabolis1.82517092
24MP0002998_abnormal_bone_remodeling1.74453400
25MP0002295_abnormal_pulmonary_circulatio1.67028158
26MP0000604_amyloidosis1.66909690
27MP0005623_abnormal_meninges_morphology1.66497615
28MP0005647_abnormal_sex_gland1.65938136
29MP0005083_abnormal_biliary_tract1.63538038
30MP0005332_abnormal_amino_acid1.60629872
31MP0003195_calcinosis1.59865655
32MP0001879_abnormal_lymphatic_vessel1.58242867
33MP0001851_eye_inflammation1.55103372
34MP0002837_dystrophic_cardiac_calcinosis1.52142344
35MP0000767_abnormal_smooth_muscle1.50547807
36MP0000681_abnormal_thyroid_gland1.49987329
37MP0009840_abnormal_foam_cell1.49769340
38MP0005187_abnormal_penis_morphology1.49371989
39MP0005023_abnormal_wound_healing1.45709311
40MP0001853_heart_inflammation1.45219065
41MP0002108_abnormal_muscle_morphology1.44049934
42MP0002060_abnormal_skin_morphology1.37082757
43MP0000013_abnormal_adipose_tissue1.32999213
44MP0000343_altered_response_to1.28091741
45MP0001542_abnormal_bone_strength1.27727268
46MP0003091_abnormal_cell_migration1.26249488
47MP0005508_abnormal_skeleton_morphology1.24692089
48* MP0009278_abnormal_bone_marrow1.24663502
49MP0000751_myopathy1.22097959
50MP0001533_abnormal_skeleton_physiology1.21935430
51MP0002118_abnormal_lipid_homeostasis1.20731977
52MP0005595_abnormal_vascular_smooth1.20535864
53MP0001666_abnormal_nutrient_absorption1.19574354
54MP0004130_abnormal_muscle_cell1.18470480
55MP0000609_abnormal_liver_physiology1.17838500
56MP0002896_abnormal_bone_mineralization1.17443279
57MP0001727_abnormal_embryo_implantation1.15532368
58MP0000639_abnormal_adrenal_gland1.14763706
59MP0005330_cardiomyopathy1.13495872
60MP0004185_abnormal_adipocyte_glucose1.11727183
61MP0005670_abnormal_white_adipose1.10391249
62MP0003566_abnormal_cell_adhesion1.09272520
63MP0005319_abnormal_enzyme/_coenzyme1.08718079
64MP0003795_abnormal_bone_structure1.07425571
65MP0001881_abnormal_mammary_gland1.06648253
66MP0005257_abnormal_intraocular_pressure1.05165511
67MP0005165_increased_susceptibility_to1.04121084
68MP0006138_congestive_heart_failure1.04069671
69MP0005084_abnormal_gallbladder_morpholo1.03927699
70MP0003300_gastrointestinal_ulcer1.02866466
71MP0003959_abnormal_lean_body1.02431640
72MP0004947_skin_inflammation0.99760833
73MP0001502_abnormal_circadian_rhythm0.99522745
74* MP0002128_abnormal_blood_circulation0.99395941
75MP0000759_abnormal_skeletal_muscle0.99170755
76MP0005666_abnormal_adipose_tissue0.98790714
77MP0005164_abnormal_response_to0.98788943
78MP0003724_increased_susceptibility_to0.98561398
79MP0005388_respiratory_system_phenotype0.96363097
80MP0002133_abnormal_respiratory_system0.96363097
81MP0001243_abnormal_dermal_layer0.96193497
82MP0002127_abnormal_cardiovascular_syste0.96100117
83MP0005369_muscle_phenotype0.92508373
84MP0008775_abnormal_heart_ventricle0.91495546
85MP0009379_abnormal_foot_pigmentation0.90347891
86MP0003385_abnormal_body_wall0.89322502
87MP0000003_abnormal_adipose_tissue0.89043900
88MP0005375_adipose_tissue_phenotype0.87914519
89MP0004883_abnormal_blood_vessel0.87713597
90MP0004084_abnormal_cardiac_muscle0.87217289
91MP0002138_abnormal_hepatobiliary_system0.85610410
92MP0006276_abnormal_autonomic_nervous0.83245300
93MP0002254_reproductive_system_inflammat0.83043229
94MP0004019_abnormal_vitamin_homeostasis0.82936369
95MP0003115_abnormal_respiratory_system0.82863183
96MP0000249_abnormal_blood_vessel0.82716080
97MP0003632_abnormal_nervous_system0.82202259
98MP0003950_abnormal_plasma_membrane0.81598222
99MP0003718_maternal_effect0.80977981
100MP0005058_abnormal_lysosome_morphology0.80770680
101MP0009643_abnormal_urine_homeostasis0.78740885
102MP0001544_abnormal_cardiovascular_syste0.78680882
103MP0005385_cardiovascular_system_phenoty0.78680882
104MP0001661_extended_life_span0.78537320
105MP0005171_absent_coat_pigmentation0.77708176
106MP0002168_other_aberrant_phenotype0.77537929
107MP0001756_abnormal_urination0.77283398
108* MP0000598_abnormal_liver_morphology0.77161076
109MP0001915_intracranial_hemorrhage0.76167518
110MP0010630_abnormal_cardiac_muscle0.75199492
111MP0005620_abnormal_muscle_contractility0.74831351
112MP0001849_ear_inflammation0.74592709
113MP0004087_abnormal_muscle_fiber0.74444095
114MP0002282_abnormal_trachea_morphology0.73790104
115MP0002249_abnormal_larynx_morphology0.73719522
116MP0009053_abnormal_anal_canal0.72719436
117* MP0001614_abnormal_blood_vessel0.71684833
118MP0002113_abnormal_skeleton_development0.71522701
119MP0002928_abnormal_bile_duct0.71145610
120MP0002115_abnormal_skeleton_extremities0.68190636
121MP0009764_decreased_sensitivity_to0.68134364
122MP0000733_abnormal_muscle_development0.67634007
123MP0005584_abnormal_enzyme/coenzyme_acti0.67563022
124MP0009250_abnormal_appendicular_skeleto0.66829508
125MP0004147_increased_porphyrin_level0.66584420
126MP0005220_abnormal_exocrine_pancreas0.66259133
127MP0003868_abnormal_feces_composition0.65072955
128* MP0001545_abnormal_hematopoietic_system0.64417104
129* MP0005397_hematopoietic_system_phenotyp0.64417104
130MP0000049_abnormal_middle_ear0.64104940
131MP0000163_abnormal_cartilage_morphology0.63782064
132MP0004036_abnormal_muscle_relaxation0.63077040
133MP0003303_peritoneal_inflammation0.62878042
134MP0000230_abnormal_systemic_arterial0.62855264
135MP0009763_increased_sensitivity_to0.62388182
136MP0003690_abnormal_glial_cell0.62023285
137MP0000747_muscle_weakness0.61587385
138MP0002972_abnormal_cardiac_muscle0.61559919
139MP0002971_abnormal_brown_adipose0.61201265
140MP0000534_abnormal_ureter_morphology0.60888310
141MP0005390_skeleton_phenotype0.60313788
142MP0008874_decreased_physiological_sensi0.59827429
143MP0009785_altered_susceptibility_to0.59766172
144MP0000432_abnormal_head_morphology0.59539101
145MP0010030_abnormal_orbit_morphology0.59468366
146MP0000858_altered_metastatic_potential0.59388829
147MP0004510_myositis0.59100039
148MP0004233_abnormal_muscle_weight0.57840815

Predicted human phenotypes

RankGene SetZ-score
1Arterial tortuosity (HP:0005116)7.33967524
2Protrusio acetabuli (HP:0003179)6.56732319
3Premature rupture of membranes (HP:0001788)5.39647174
4Deep venous thrombosis (HP:0002625)5.18027269
5Metaphyseal cupping (HP:0003021)4.28939488
6Osteomalacia (HP:0002749)4.20671824
7Broad metatarsal (HP:0001783)4.19400722
8Ankle contracture (HP:0006466)4.17337460
9Intrahepatic cholestasis (HP:0001406)4.01558151
10Xanthomatosis (HP:0000991)3.97020615
11Pulmonary artery stenosis (HP:0004415)3.92268720
12Widely patent fontanelles and sutures (HP:0004492)3.91552201
13Aortic regurgitation (HP:0001659)3.82065920
14Aortic aneurysm (HP:0004942)3.77932831
15Aortic dissection (HP:0002647)3.75467799
16Abnormality of aromatic amino acid family metabolism (HP:0004338)3.74642744
17Peritonitis (HP:0002586)3.70971544
18Abnormality of the costochondral junction (HP:0000919)3.66587714
19Prolonged partial thromboplastin time (HP:0003645)3.64580786
20Polyphagia (HP:0002591)3.59074374
21Abnormality of monocarboxylic acid metabolism (HP:0010996)3.56431676
22Hyperlipoproteinemia (HP:0010980)3.43085287
23Complement deficiency (HP:0004431)3.31977184
24Papilledema (HP:0001085)3.26103247
25Wide cranial sutures (HP:0010537)3.19610019
26Hypoalphalipoproteinemia (HP:0003233)3.16618313
27Aortic valve stenosis (HP:0001650)3.10926194
28Cerebral aneurysm (HP:0004944)3.07457969
29Abnormal vertebral ossification (HP:0100569)3.06807643
30Abnormality of skull ossification (HP:0002703)3.06797978
31Abnormality of the common coagulation pathway (HP:0010990)3.03561741
32Systemic lupus erythematosus (HP:0002725)3.02683945
33Nonimmune hydrops fetalis (HP:0001790)3.01552909
34Asymmetric septal hypertrophy (HP:0001670)2.99672378
35Type 1 muscle fiber predominance (HP:0003803)2.98442914
36Follicular hyperkeratosis (HP:0007502)2.93645886
37Hypoglycemic coma (HP:0001325)2.90987352
38Bladder diverticulum (HP:0000015)2.89234152
39Biconcave vertebral bodies (HP:0004586)2.88873880
40Soft skin (HP:0000977)2.88013988
41Hypobetalipoproteinemia (HP:0003563)2.86205848
42Hypolipoproteinemia (HP:0010981)2.82080168
43Premature loss of primary teeth (HP:0006323)2.81231584
44Shallow orbits (HP:0000586)2.76609211
45Abnormality of the intrinsic pathway (HP:0010989)2.76272856
46Atrophic scars (HP:0001075)2.71843002
47Ketosis (HP:0001946)2.71517974
48Increased connective tissue (HP:0009025)2.70468519
49Growth hormone deficiency (HP:0000824)2.70228090
50Joint stiffness (HP:0001387)2.70134437
51Neonatal short-limb short stature (HP:0008921)2.68126239
52Mitral valve prolapse (HP:0001634)2.66758251
53Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.65360532
54Hyperammonemia (HP:0001987)2.62148488
55Spinal rigidity (HP:0003306)2.60210899
56Dilatation of the ascending aorta (HP:0005111)2.59004068
57Mitral stenosis (HP:0001718)2.56900929
58Keratoconus (HP:0000563)2.56344046
59Increased corneal curvature (HP:0100692)2.56344046
60Blue sclerae (HP:0000592)2.55398890
61Skin nodule (HP:0200036)2.54912365
62Joint hemorrhage (HP:0005261)2.54424723
63Abnormality of complement system (HP:0005339)2.53895338
64Myocardial infarction (HP:0001658)2.53203015
65Cardiovascular calcification (HP:0011915)2.53021169
66Abnormality of dentin (HP:0010299)2.51971564
67Decreased skull ossification (HP:0004331)2.51524592
68Aneurysm (HP:0002617)2.50535104
69Epidermoid cyst (HP:0200040)2.45083535
70Chondrocalcinosis (HP:0000934)2.44174242
71Increased variability in muscle fiber diameter (HP:0003557)2.42676697
72Cervical subluxation (HP:0003308)2.41859691
73Abnormal delivery (HP:0001787)2.40468988
74Ectopia lentis (HP:0001083)2.40246744
75Turricephaly (HP:0000262)2.39356298
76Axonal loss (HP:0003447)2.36919895
77Joint laxity (HP:0001388)2.36878028
78Abnormality of glutamine family amino acid metabolism (HP:0010902)2.36854733
79Spondylolisthesis (HP:0003302)2.34103989
80Vertebral clefting (HP:0008428)2.31572134
81Abnormality of Sharpey fibers (HP:0100685)2.29670189
82Lymphangioma (HP:0100764)2.25590001
83Abnormality of the diencephalon (HP:0010662)2.25583245
84Ketoacidosis (HP:0001993)2.25275382
85Wormian bones (HP:0002645)2.25208984
86Vascular tortuosity (HP:0004948)2.23763435
87Vertebral compression fractures (HP:0002953)2.23507405
88Abnormality of sulfur amino acid metabolism (HP:0004339)2.22734243
89Thin skin (HP:0000963)2.21377200
90Malnutrition (HP:0004395)2.19485737
91Esophageal varix (HP:0002040)2.19119035
92Hyperglycinemia (HP:0002154)2.18779078
93Infantile muscular hypotonia (HP:0008947)2.18451790
94Fragile skin (HP:0001030)2.18264422
95Mildly elevated creatine phosphokinase (HP:0008180)2.17449578
96Abnormality of serine family amino acid metabolism (HP:0010894)2.16476704
97Abnormality of glycine metabolism (HP:0010895)2.16476704
98Abnormal cartilage morphology (HP:0002763)2.14996415
99Delayed CNS myelination (HP:0002188)2.14769098
100Slender build (HP:0001533)2.14366777
101Stroke (HP:0001297)2.13780312
102Osteolytic defects of the hand bones (HP:0009699)2.12196839
103Osteolytic defects of the phalanges of the hand (HP:0009771)2.12196839
104Abnormality of aspartate family amino acid metabolism (HP:0010899)2.11629986
105Wide anterior fontanel (HP:0000260)2.11531624
106Abnormality of fatty-acid metabolism (HP:0004359)2.11130214
107Spontaneous hematomas (HP:0007420)2.09867094
108Vascular calcification (HP:0004934)2.09639436
109Overgrowth (HP:0001548)2.07192758
110Hypercholesterolemia (HP:0003124)2.06535029
111Wrist flexion contracture (HP:0001239)2.06388055
112Short nail (HP:0001799)2.05502121
113Hyperglycinuria (HP:0003108)2.05207259
114Fat malabsorption (HP:0002630)2.05109030
115Abnormality of methionine metabolism (HP:0010901)2.05050299
116Abnormality of skeletal muscle fiber size (HP:0012084)2.03954349
117Right ventricular cardiomyopathy (HP:0011663)2.02892469
118Hepatocellular carcinoma (HP:0001402)2.02739172
119Hemorrhage of the eye (HP:0011885)2.01093906
120Bell-shaped thorax (HP:0001591)1.99880409
121Hydroxyprolinuria (HP:0003080)1.99663911
122Abnormality of proline metabolism (HP:0010907)1.99663911
123Hypercalcemia (HP:0003072)1.98441640
124Short hallux (HP:0010109)1.96654910
125Venous insufficiency (HP:0005293)1.94892377
126Ulnar bowing (HP:0003031)1.93948747
127Hyperextensible skin (HP:0000974)1.92604304
128Bone cyst (HP:0012062)1.91646327
129Hypoplasia of the iris (HP:0007676)1.91412772
130Abnormal eating behavior (HP:0100738)1.90934303
131Dysostosis multiplex (HP:0000943)1.89629933
132Venous abnormality (HP:0002624)1.89019830
133Polycythemia (HP:0001901)1.88235464
134Ovoid vertebral bodies (HP:0003300)1.87813393
135Metaphyseal dysplasia (HP:0100255)1.83700435
136Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.83331925
137Abnormality of the Achilles tendon (HP:0005109)1.82582660
138Generalized amyotrophy (HP:0003700)1.80615464
139Aplasia/Hypoplasia of the hallux (HP:0008362)1.79649923
140Camptodactyly of toe (HP:0001836)1.79257233
141Ileus (HP:0002595)1.77484503
142Elbow flexion contracture (HP:0002987)1.76971714
143Bowel diverticulosis (HP:0005222)1.76780840
144Genu recurvatum (HP:0002816)1.76257314
145Round ear (HP:0100830)1.75078874
146Spontaneous abortion (HP:0005268)1.74441811
147Mesangial abnormality (HP:0001966)1.73987999
148Abnormality of primary teeth (HP:0006481)1.72949863
149Long toe (HP:0010511)1.71907161
150Mucopolysacchariduria (HP:0008155)1.69547009
151Urinary glycosaminoglycan excretion (HP:0003541)1.69547009
152Pathologic fracture (HP:0002756)1.68511294

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDGFRA3.95704327
2TTN3.81989096
3ERN13.48988347
4TRIB33.19166462
5DDR23.15612647
6SIK13.12882621
7MYLK3.12785517
8TIE13.06817072
9KDR2.98795451
10MOS2.81283651
11BCKDK2.52707913
12PKN22.50677290
13LATS12.36280363
14GRK72.29792349
15FGFR42.29714878
16GRK52.26746915
17EPHB22.13961678
18INSRR2.06048792
19RIPK11.94071972
20KIT1.74097774
21TESK11.71006444
22MAPK41.63638095
23TGFBR21.61932964
24DMPK1.59470590
25FGFR21.55044723
26PTK61.54201735
27PAK21.53827471
28FRK1.52721510
29LATS21.50390002
30EPHA31.47776685
31ABL21.34698558
32PAK31.26712257
33EPHB11.24988528
34PDGFRB1.24406255
35MET1.23196654
36PTK2B1.21863210
37FER1.20824371
38MAPKAPK21.18681465
39ARAF1.17360294
40NEK91.08932041
41JAK11.04686891
42PIK3CG1.04370580
43LIMK11.03180880
44PTK21.02277716
45CAMK1D1.01962951
46JAK30.96826891
47MAP3K110.95838073
48DAPK30.93705491
49ERBB40.93343775
50PIK3CA0.93301199
51FLT30.93141461
52MAPKAPK30.90586096
53RPS6KA20.86390737
54MAP2K10.84653138
55TYK20.84642987
56ROCK10.79921526
57TNK20.79849111
58RET0.79300854
59NLK0.77624166
60LRRK20.73871809
61TRPM70.72384164
62MAP3K70.70674711
63PRKD10.70563470
64BMX0.67320675
65MST1R0.66216318
66CDC42BPA0.66172399
67RPS6KL10.64991901
68RPS6KC10.64991901
69LMTK20.64439783
70DAPK20.63871827
71STK30.62853807
72CAMK1G0.62465270
73STK100.62355733
74MAP2K30.62040967
75MTOR0.61595756
76PRKCH0.61255579
77MAPK70.60786186
78FGFR30.60314354
79FGFR10.59584063
80MAPK110.58697247
81ROCK20.58274317
82PRKAA20.58070849
83INSR0.57322533
84NTRK10.57012842
85GRK60.56952153
86STK38L0.56138584
87MAPK120.55417451
88CDK80.55172827
89JAK20.55081378
90CDK60.53598958
91GSK3A0.53056736
92PDK30.52725722
93PDK40.52725722
94ICK0.51228621
95IGF1R0.51081471
96GRK10.51076004
97CLK10.49365587
98ZAP700.49017886
99RPS6KA60.48707159
100STK380.47833055
101TGFBR10.47385952
102TAOK20.45870139
103MAP3K100.45801055
104MAP3K60.44982303
105CAMK40.44351894
106MAPK30.44094926
107PAK40.43460914
108PHKG20.43378358
109PHKG10.43378358
110PDK20.43184511
111PRKCE0.41427711
112ERBB20.41403029
113MAP2K40.40883208
114ADRBK10.40379001
115MAP3K10.40320803
116PRKACB0.40253632
117PAK10.39954037
118MAP2K20.39365218
119PRKG20.38512882
120PRKCD0.38368042
121SRC0.38342331
122ILK0.38305339
123MAPK10.37821305
124PDPK10.37408079
125OBSCN0.37261191
126EIF2AK20.36988389
127PRKD20.36838035
128MAP3K30.36832235
129CAMK2G0.36199271
130PRPF4B0.35878522
131PIM20.35727776
132CAMK2D0.35002178
133RPS6KA40.33754940
134CDK30.33549139
135NUAK10.33405976
136PKN10.33361303
137DYRK1B0.31744310
138MAPK150.30530974
139ABL10.29500250
140CSK0.29361550
141MARK20.28563453

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.81727058
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.20397317
3Nitrogen metabolism_Homo sapiens_hsa009103.18347804
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.92439272
5Arginine biosynthesis_Homo sapiens_hsa002202.72709686
6Complement and coagulation cascades_Homo sapiens_hsa046102.70079797
7Fatty acid degradation_Homo sapiens_hsa000712.61086288
8Tryptophan metabolism_Homo sapiens_hsa003802.60298313
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.37985687
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.36254250
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.27484917
12PPAR signaling pathway_Homo sapiens_hsa033202.15784216
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.07804882
14Propanoate metabolism_Homo sapiens_hsa006402.04943035
15Fatty acid metabolism_Homo sapiens_hsa012121.97350440
16Caffeine metabolism_Homo sapiens_hsa002321.96452517
17Glycosaminoglycan degradation_Homo sapiens_hsa005311.95804917
18Butanoate metabolism_Homo sapiens_hsa006501.93362754
19Pentose and glucuronate interconversions_Homo sapiens_hsa000401.77173084
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.74345386
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.70390264
22Chemical carcinogenesis_Homo sapiens_hsa052041.70319894
23Steroid hormone biosynthesis_Homo sapiens_hsa001401.67267385
24Peroxisome_Homo sapiens_hsa041461.66474567
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.61995972
26Bile secretion_Homo sapiens_hsa049761.58272167
27beta-Alanine metabolism_Homo sapiens_hsa004101.52050907
28Arachidonic acid metabolism_Homo sapiens_hsa005901.51848315
29ECM-receptor interaction_Homo sapiens_hsa045121.50727409
30Phenylalanine metabolism_Homo sapiens_hsa003601.50325334
31Histidine metabolism_Homo sapiens_hsa003401.44574606
32Staphylococcus aureus infection_Homo sapiens_hsa051501.42908273
33Renin-angiotensin system_Homo sapiens_hsa046141.35065242
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.31332787
35Retinol metabolism_Homo sapiens_hsa008301.24305506
36Starch and sucrose metabolism_Homo sapiens_hsa005001.21304902
37Tyrosine metabolism_Homo sapiens_hsa003501.20537208
38Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.20513711
39Pyruvate metabolism_Homo sapiens_hsa006201.19552894
40Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.12433058
41Other glycan degradation_Homo sapiens_hsa005111.11369673
42TNF signaling pathway_Homo sapiens_hsa046681.10869113
43Focal adhesion_Homo sapiens_hsa045101.10613734
44Fatty acid elongation_Homo sapiens_hsa000621.09836238
45Drug metabolism - other enzymes_Homo sapiens_hsa009831.07449413
46Selenocompound metabolism_Homo sapiens_hsa004501.03240700
47Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.02689401
48Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.01446560
49Carbon metabolism_Homo sapiens_hsa012001.01118473
50ABC transporters_Homo sapiens_hsa020101.00378919
51Lysine degradation_Homo sapiens_hsa003100.99488412
52Sulfur metabolism_Homo sapiens_hsa009200.97540446
53Osteoclast differentiation_Homo sapiens_hsa043800.96980709
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.96619674
55Arginine and proline metabolism_Homo sapiens_hsa003300.95921245
56Fat digestion and absorption_Homo sapiens_hsa049750.95332969
57African trypanosomiasis_Homo sapiens_hsa051430.93887167
58Protein digestion and absorption_Homo sapiens_hsa049740.91785466
59Pertussis_Homo sapiens_hsa051330.87817678
60Biosynthesis of amino acids_Homo sapiens_hsa012300.86406238
61Amoebiasis_Homo sapiens_hsa051460.76584024
62Cyanoamino acid metabolism_Homo sapiens_hsa004600.74388476
63Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.71575023
64Long-term depression_Homo sapiens_hsa047300.70969721
65Cysteine and methionine metabolism_Homo sapiens_hsa002700.68366822
66Folate biosynthesis_Homo sapiens_hsa007900.65722564
67Insulin resistance_Homo sapiens_hsa049310.65676596
68Vitamin B6 metabolism_Homo sapiens_hsa007500.64982298
69Adipocytokine signaling pathway_Homo sapiens_hsa049200.63941505
70Jak-STAT signaling pathway_Homo sapiens_hsa046300.61831951
71Sulfur relay system_Homo sapiens_hsa041220.60941882
72Adherens junction_Homo sapiens_hsa045200.60197165
73Vitamin digestion and absorption_Homo sapiens_hsa049770.56131832
74Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.55324991
75Malaria_Homo sapiens_hsa051440.55099608
76Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54867232
77Dilated cardiomyopathy_Homo sapiens_hsa054140.54428667
78Glycerolipid metabolism_Homo sapiens_hsa005610.53938326
79* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53856101
80Proteoglycans in cancer_Homo sapiens_hsa052050.53365357
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52992884
82Hematopoietic cell lineage_Homo sapiens_hsa046400.52928552
83Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52480464
84* Rheumatoid arthritis_Homo sapiens_hsa053230.52250530
85Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51395051
86Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.51124117
87AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.49742418
88Steroid biosynthesis_Homo sapiens_hsa001000.49233250
89Lysosome_Homo sapiens_hsa041420.48966096
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47878816
91HTLV-I infection_Homo sapiens_hsa051660.47583799
92Renin secretion_Homo sapiens_hsa049240.47298372
93Phospholipase D signaling pathway_Homo sapiens_hsa040720.47013345
94N-Glycan biosynthesis_Homo sapiens_hsa005100.46872328
95Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46548896
96Bladder cancer_Homo sapiens_hsa052190.45676365
97PI3K-Akt signaling pathway_Homo sapiens_hsa041510.43160788
98Fatty acid biosynthesis_Homo sapiens_hsa000610.43016227
99Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.42241585
100Choline metabolism in cancer_Homo sapiens_hsa052310.42114942
101cGMP-PKG signaling pathway_Homo sapiens_hsa040220.41826933
102Ovarian steroidogenesis_Homo sapiens_hsa049130.39856368
103AMPK signaling pathway_Homo sapiens_hsa041520.39738847
104Prolactin signaling pathway_Homo sapiens_hsa049170.38070660
105Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.37664749
106Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37468690
107Prion diseases_Homo sapiens_hsa050200.37173715
108Glutathione metabolism_Homo sapiens_hsa004800.36973184
109Regulation of actin cytoskeleton_Homo sapiens_hsa048100.36575570
110Gap junction_Homo sapiens_hsa045400.35984124
111Platelet activation_Homo sapiens_hsa046110.35038112
112Central carbon metabolism in cancer_Homo sapiens_hsa052300.34052237
113GnRH signaling pathway_Homo sapiens_hsa049120.33513108
114TGF-beta signaling pathway_Homo sapiens_hsa043500.31511001
115Melanoma_Homo sapiens_hsa052180.31262727
116Phagosome_Homo sapiens_hsa041450.31051454
117Maturity onset diabetes of the young_Homo sapiens_hsa049500.30387111
118Thyroid hormone synthesis_Homo sapiens_hsa049180.29758924
119Glucagon signaling pathway_Homo sapiens_hsa049220.28817932
120Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.28565680
121Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.28565537
122Ras signaling pathway_Homo sapiens_hsa040140.28118782
123Vascular smooth muscle contraction_Homo sapiens_hsa042700.26737150
124Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.26083955
125* Pathways in cancer_Homo sapiens_hsa052000.25967454
126Apoptosis_Homo sapiens_hsa042100.24994780
127Renal cell carcinoma_Homo sapiens_hsa052110.23560320
128Small cell lung cancer_Homo sapiens_hsa052220.23380714
129Salmonella infection_Homo sapiens_hsa051320.22629162
130Oxytocin signaling pathway_Homo sapiens_hsa049210.22373419
131Melanogenesis_Homo sapiens_hsa049160.21369377
132Basal cell carcinoma_Homo sapiens_hsa052170.20857591
133Rap1 signaling pathway_Homo sapiens_hsa040150.20605886
134Aldosterone synthesis and secretion_Homo sapiens_hsa049250.19039666
135Estrogen signaling pathway_Homo sapiens_hsa049150.18157342
136Hepatitis C_Homo sapiens_hsa051600.17197000
137Mineral absorption_Homo sapiens_hsa049780.16769505
138Prostate cancer_Homo sapiens_hsa052150.16326950
139Glioma_Homo sapiens_hsa052140.16252602
140Fructose and mannose metabolism_Homo sapiens_hsa000510.16172324
141Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.16155711
142* NF-kappa B signaling pathway_Homo sapiens_hsa040640.15827121
143* Leukocyte transendothelial migration_Homo sapiens_hsa046700.15265315
144Insulin signaling pathway_Homo sapiens_hsa049100.15234562
145Toxoplasmosis_Homo sapiens_hsa051450.15169385
146Dorso-ventral axis formation_Homo sapiens_hsa043200.14982536
147MicroRNAs in cancer_Homo sapiens_hsa052060.14046421
148Gastric acid secretion_Homo sapiens_hsa049710.13570063

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