CXCL17

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a mucosal chemokine that attracts immature dendritic cells and blood monocytes to the lungs. The encoded protein also promotes tumorigenesis through an angiogenic activity. Finally, this protein exhibits strong antimicrobial activity against E. coli, S. aureus, Salmonella, P. aeruginosa, and C. albicans. Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axoneme assembly (GO:0035082)9.72920967
2ethanol oxidation (GO:0006069)8.80086366
3left/right pattern formation (GO:0060972)8.34669186
4chemical homeostasis within a tissue (GO:0048875)8.04152037
5L-ascorbic acid metabolic process (GO:0019852)7.49451187
6one-carbon compound transport (GO:0019755)7.24462147
7ethanol metabolic process (GO:0006067)7.16983680
8regulation of cilium movement (GO:0003352)6.87442977
9interferon-gamma secretion (GO:0072643)6.55700850
10lung lobe morphogenesis (GO:0060463)6.24542238
11ventricular system development (GO:0021591)6.01419960
12microtubule bundle formation (GO:0001578)5.94280908
13positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.89175368
14negative regulation of epidermal cell differentiation (GO:0045605)5.84237336
15xenobiotic catabolic process (GO:0042178)5.83742805
16primary alcohol catabolic process (GO:0034310)5.73438183
17regulation of toll-like receptor 4 signaling pathway (GO:0034143)5.68030898
18gas transport (GO:0015669)5.67531910
19pyrimidine-containing compound transmembrane transport (GO:0072531)5.55347176
20glutathione derivative metabolic process (GO:1901685)5.54132861
21glutathione derivative biosynthetic process (GO:1901687)5.54132861
22intraciliary transport (GO:0042073)5.51435869
23terpenoid biosynthetic process (GO:0016114)5.49170877
24response to xenobiotic stimulus (GO:0009410)5.41077405
25regulation of skeletal muscle contraction (GO:0014819)5.30445390
26cilium organization (GO:0044782)5.21172051
27cilium assembly (GO:0042384)5.01134846
28lung epithelium development (GO:0060428)4.98139039
29positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003604.87073988
30negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)4.80278928
31tolerance induction (GO:0002507)4.76560385
32hemidesmosome assembly (GO:0031581)4.68365639
33negative regulation of epidermis development (GO:0045683)4.62340188
34negative regulation of B cell mediated immunity (GO:0002713)4.48372874
35negative regulation of immunoglobulin mediated immune response (GO:0002890)4.48372874
36negative regulation of T cell differentiation in thymus (GO:0033085)4.35221569
37regulation of interleukin-5 production (GO:0032674)4.33422866
38centriole assembly (GO:0098534)4.32796754
39cellular response to arsenic-containing substance (GO:0071243)4.26991410
40cilium movement (GO:0003341)4.26464465
41negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)4.25672291
42sperm capacitation (GO:0048240)4.22208491
43protein localization to cilium (GO:0061512)4.22014379
44positive regulation of osteoblast proliferation (GO:0033690)4.13302448
45epithelial cell differentiation involved in prostate gland development (GO:0060742)4.12457540
46microtubule-based movement (GO:0007018)4.07131655
47cellular component assembly involved in morphogenesis (GO:0010927)4.03388238
48regulation of germinal center formation (GO:0002634)4.02016996
49positive regulation of tolerance induction (GO:0002645)4.01714328
50regulation of microtubule-based movement (GO:0060632)3.94192973
51negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.92424772
52regulation of interleukin-13 production (GO:0032656)3.87923823
53regulation of keratinocyte proliferation (GO:0010837)3.86778460
54negative regulation of humoral immune response (GO:0002921)3.80439577
55cell projection assembly (GO:0030031)3.78345921
56progesterone metabolic process (GO:0042448)3.77067953
57dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.67883027
58multicellular organismal water homeostasis (GO:0050891)3.66333214
59establishment of planar polarity (GO:0001736)3.64903935
60establishment of tissue polarity (GO:0007164)3.64903935
61lateral ventricle development (GO:0021670)3.63309284
62regulation of keratinocyte differentiation (GO:0045616)3.62237815
63cilium morphogenesis (GO:0060271)3.58943799
64bundle of His cell to Purkinje myocyte communication (GO:0086069)3.58091631
65retinol metabolic process (GO:0042572)3.55490464
66cytoplasmic microtubule organization (GO:0031122)3.52842526
67establishment of apical/basal cell polarity (GO:0035089)3.47650729
68positive regulation of hormone biosynthetic process (GO:0046886)3.45358189
69renal absorption (GO:0070293)3.43538763
70positive regulation of vesicle fusion (GO:0031340)3.42595331
71positive regulation of wound healing (GO:0090303)3.41403635
72nucleoside diphosphate phosphorylation (GO:0006165)3.35306341
73O-glycan processing (GO:0016266)3.34196975
74axonemal dynein complex assembly (GO:0070286)3.33017882
75regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00433.32553851
76diterpenoid biosynthetic process (GO:0016102)3.31153940
77exogenous drug catabolic process (GO:0042738)3.23697454
78response to nitrosative stress (GO:0051409)3.22423443
79detection of other organism (GO:0098543)3.22033548
80water homeostasis (GO:0030104)3.21141919
81toxin metabolic process (GO:0009404)3.19747418
82negative regulation of complement activation (GO:0045916)3.18818303
83hydrogen peroxide biosynthetic process (GO:0050665)3.18500311
84intestinal epithelial cell development (GO:0060576)3.17058996
85negative regulation of inclusion body assembly (GO:0090084)3.12277385
86vitamin transmembrane transport (GO:0035461)3.10499181
87oligosaccharide biosynthetic process (GO:0009312)3.10294247
88lung vasculature development (GO:0060426)3.09883828
89camera-type eye morphogenesis (GO:0048593)3.08611399
90positive regulation of steroid biosynthetic process (GO:0010893)3.07183850
91branching involved in salivary gland morphogenesis (GO:0060445)3.06995901
92epithelial tube branching involved in lung morphogenesis (GO:0060441)3.06557264
93detection of bacterium (GO:0016045)3.04751500
94establishment or maintenance of monopolar cell polarity (GO:0061339)3.03045216
95establishment of monopolar cell polarity (GO:0061162)3.03045216
96regulation of tolerance induction (GO:0002643)3.01522686
97excretion (GO:0007588)3.01326446
98phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.01035551
99retinoic acid metabolic process (GO:0042573)2.97862395
100iron ion import (GO:0097286)2.96685460
101apical protein localization (GO:0045176)2.95651415
102retinal metabolic process (GO:0042574)2.95194689
103tight junction assembly (GO:0070830)2.95053870
104innate immune response in mucosa (GO:0002227)2.93977665
105mesodermal cell differentiation (GO:0048333)2.91077536
106acute-phase response (GO:0006953)2.90709473
107negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.90169564
108protein O-linked glycosylation (GO:0006493)2.90166006
109microtubule depolymerization (GO:0007019)2.89605147
110maintenance of gastrointestinal epithelium (GO:0030277)2.89579431
111positive regulation of toll-like receptor signaling pathway (GO:0034123)2.88940113
112lateral sprouting from an epithelium (GO:0060601)2.86498547
113polyol transport (GO:0015791)2.84591380
114left/right axis specification (GO:0070986)2.84322996
115cell adhesion mediated by integrin (GO:0033627)2.84183074
116retinal rod cell development (GO:0046548)2.83917252
117regulation of steroid hormone biosynthetic process (GO:0090030)2.83824842
118cilium or flagellum-dependent cell motility (GO:0001539)2.82799867
119reactive oxygen species biosynthetic process (GO:1903409)2.81510279
120epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.80612585
121primary alcohol metabolic process (GO:0034308)2.79015769
122positive regulation of smoothened signaling pathway (GO:0045880)2.78929560
123microtubule polymerization or depolymerization (GO:0031109)2.78112272
124cellular aldehyde metabolic process (GO:0006081)2.77440980
125regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.75969456
126ear development (GO:0043583)2.70997712
127face development (GO:0060324)2.70576098
128cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.70271356
129hormone catabolic process (GO:0042447)2.69526456
130flavonoid metabolic process (GO:0009812)2.69301253
131regulation of response to osmotic stress (GO:0047484)2.68906033
132xenobiotic metabolic process (GO:0006805)2.66787493
133regulation of autophagic vacuole assembly (GO:2000785)2.66296062
134epithelial structure maintenance (GO:0010669)2.65969136
135regulation of microtubule depolymerization (GO:0031114)2.65918442
136positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.65801212
137hydrogen peroxide catabolic process (GO:0042744)2.64440105
138sodium ion homeostasis (GO:0055078)2.63610640
139aldehyde catabolic process (GO:0046185)2.63510745
140calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.61892639
141positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.61113411
142peptide catabolic process (GO:0043171)2.60035225
143negative regulation of protein activation cascade (GO:2000258)2.59243462
144daunorubicin metabolic process (GO:0044597)2.58687554
145polyketide metabolic process (GO:0030638)2.58687554
146doxorubicin metabolic process (GO:0044598)2.58687554
147lung-associated mesenchyme development (GO:0060484)2.56234790
148carnitine metabolic process (GO:0009437)2.56079632
149positive regulation of endothelial cell differentiation (GO:0045603)2.55666515
150regulation of cholesterol biosynthetic process (GO:0045540)2.52499014
151regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2.51982734
152drug catabolic process (GO:0042737)2.51335365
153hypotonic response (GO:0006971)2.50098864
154cellular copper ion homeostasis (GO:0006878)2.49395310
155desmosome organization (GO:0002934)2.48841997
156nitric oxide biosynthetic process (GO:0006809)2.48548633
157phosphatidylcholine biosynthetic process (GO:0006656)2.47854720
158regulation of secondary heart field cardioblast proliferation (GO:0003266)2.46748752
159regulation of cardioblast proliferation (GO:0003264)2.46748752
160glomerular epithelial cell development (GO:0072310)2.46537042
161regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.46012235
162motile cilium assembly (GO:0044458)13.7383234
163epithelial cilium movement (GO:0003351)12.3256608
164surfactant homeostasis (GO:0043129)10.0704048

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse6.40985327
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.28449057
3TRIM28_21343339_ChIP-Seq_HEK293_Human4.96794003
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.42055131
5RARG_19884340_ChIP-ChIP_MEFs_Mouse3.88003679
6ESR1_21235772_ChIP-Seq_MCF-7_Human3.43015374
7ESR1_20079471_ChIP-ChIP_T-47D_Human3.28913967
8FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human3.02572748
9ESR2_21235772_ChIP-Seq_MCF-7_Human2.96553542
10SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.94639899
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.93153045
12ESR1_15608294_ChIP-ChIP_MCF-7_Human2.75174648
13* SOX2_27498859_Chip-Seq_STOMACH_Mouse2.66447197
14DROSHA_22980978_ChIP-Seq_HELA_Human2.60340565
15SOX2_20726797_ChIP-Seq_SW620_Human2.39626006
16ZNF217_24962896_ChIP-Seq_MCF-7_Human2.35579287
17PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.32597079
18STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.24200817
19CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.13026709
20CLOCK_20551151_ChIP-Seq_293T_Human2.11843430
21PPAR_26484153_Chip-Seq_NCI-H1993_Human2.09943360
22PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.09897820
23AHR_22903824_ChIP-Seq_MCF-7_Human1.97546469
24ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.92164396
25TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.89590180
26HIF1A_21447827_ChIP-Seq_MCF-7_Human1.88375064
27ZNF263_19887448_ChIP-Seq_K562_Human1.81517927
28SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.80217540
29SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.80217540
30* GATA4_25053715_ChIP-Seq_YYC3_Human1.73325830
31FOXO3_23340844_ChIP-Seq_DLD1_Human1.66879121
32CDX2_20551321_ChIP-Seq_CACO-2_Human1.61911313
33TCF4_18268006_ChIP-ChIP_LS174T_Human1.59480698
34RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.59437402
35FOXM1_26456572_ChIP-Seq_MCF-7_Human1.59190462
36KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.56773988
37FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.56643013
38NRF2_20460467_ChIP-Seq_MEFs_Mouse1.56458171
39NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.56458171
40NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.56040356
41SOX9_24532713_ChIP-Seq_HFSC_Mouse1.54562874
42SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.51946487
43BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.51016507
44SMC4_20622854_ChIP-Seq_HELA_Human1.51005017
45FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.50786597
46ARNT_22903824_ChIP-Seq_MCF-7_Human1.50685325
47RUNX1_27514584_Chip-Seq_MCF-7_Human1.47765349
48STAT1_20625510_ChIP-Seq_HELA_Human1.46955369
49KLF5_25053715_ChIP-Seq_YYC3_Human1.43541003
50TP53_18474530_ChIP-ChIP_U2OS_Human1.42817821
51TP63_22573176_ChIP-Seq_HFKS_Human1.42340725
52RACK7_27058665_Chip-Seq_MCF-7_Human1.42083104
53SALL4_18804426_ChIP-ChIP_XEN_Mouse1.41222688
54GATA2_21666600_ChIP-Seq_HMVEC_Human1.40759245
55STAT6_21828071_ChIP-Seq_BEAS2B_Human1.40051870
56PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.39775259
57KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.38948469
58PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.36591033
59* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.34812219
60CTNNB1_20460455_ChIP-Seq_HCT116_Human1.34066760
61GATA3_24758297_ChIP-Seq_MCF-7_Human1.33420743
62* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.30287604
63GATA1_22025678_ChIP-Seq_K562_Human1.27910374
64ETV1_20927104_ChIP-Seq_GIST48_Human1.26431407
65GATA6_25053715_ChIP-Seq_YYC3_Human1.26316027
66AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.24966104
67LXR_22158963_ChIP-Seq_LIVER_Mouse1.24835148
68ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.23972899
69CJUN_26792858_Chip-Seq_BT549_Human1.23465596
70BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.22512824
71CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.20874683
72PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.19273016
73* RAD21_21589869_ChIP-Seq_MESCs_Mouse1.18938382
74PIAS1_25552417_ChIP-Seq_VCAP_Human1.18678585
75RXR_22158963_ChIP-Seq_LIVER_Mouse1.18190297
76NR3C1_21868756_ChIP-Seq_MCF10A_Human1.15890090
77GATA1_19941826_ChIP-Seq_K562_Human1.14735956
78FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.14591478
79CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.14508332
80ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.14439639
81TDRD3_21172665_ChIP-Seq_MCF-7_Human1.12406323
82ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.12332362
83SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.11453180
84CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.11387959
85HNFA_21074721_ChIP-Seq_CACO-2_Human1.10571660
86IKZF1_21737484_ChIP-ChIP_HCT116_Human1.10402094
87Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.10181171
88PHF8_20622853_ChIP-Seq_HELA_Human1.09740369
89FOXA1_25552417_ChIP-Seq_VCAP_Human1.09545278
90SMRT_27268052_Chip-Seq_Bcells_Human1.08626673
91EGR1_19374776_ChIP-ChIP_THP-1_Human1.06662811
92GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06379353
93RBPJ_21746931_ChIP-Seq_IB4_Human1.06351513
94VDR_22108803_ChIP-Seq_LS180_Human1.05918768
95EP300_21415370_ChIP-Seq_HL-1_Mouse1.05264445
96CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.05143437
97CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.05062233
98CREB1_26743006_Chip-Seq_LNCaP_Human1.05051573
99PPARA_22158963_ChIP-Seq_LIVER_Mouse1.04443060
100GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.01168812
101CDX2_19796622_ChIP-Seq_MESCs_Mouse1.01098025
102GATA6_21074721_ChIP-Seq_CACO-2_Human0.99518281
103JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99134612
104TP63_23658742_ChIP-Seq_EP156T_Human0.99059837
105CBX2_22325352_ChIP-Seq_293T-Rex_Human0.97199031
106P63_26484246_Chip-Seq_KERATINOCYTES_Human0.96797407
107CEBPB_22108803_ChIP-Seq_LS180_Human0.96245407
108FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.95775635
109ELF1_20517297_ChIP-Seq_JURKAT_Human0.94111931
110NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.91240995
111* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.90812694
112RXR_22108803_ChIP-Seq_LS180_Human0.90410525
113TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.89345466
114NFYA_21822215_ChIP-Seq_K562_Human0.87979427
115ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.87867433
116STAT3_1855785_ChIP-Seq_MESCs_Mouse0.87000802
117STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.86903520
118CTCF_20526341_ChIP-Seq_ESCs_Human0.85169077
119AR_21572438_ChIP-Seq_LNCaP_Human0.85148549
120TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83277395
121ATF3_27146783_Chip-Seq_COLON_Human0.83140578
122* CTCF_27219007_Chip-Seq_Bcells_Human0.83098258
123YY1_22570637_ChIP-Seq_MALME-3M_Human0.82706210
124NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.82068330
125NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.80453827
126JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.79975876
127TOP2B_26459242_ChIP-Seq_MCF-7_Human0.79883187
128TBX20_22080862_ChIP-Seq_HEART_Mouse0.79864527
129TBX20_22328084_ChIP-Seq_HEART_Mouse0.79864527
130NANOG_18692474_ChIP-Seq_MEFs_Mouse0.79648873
131P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.79603530
132P68_20966046_ChIP-Seq_HELA_Human0.79524626
133NFYB_21822215_ChIP-Seq_K562_Human0.78535791
134P300_27268052_Chip-Seq_Bcells_Human0.77908749
135TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.76706006
136ELF5_23300383_ChIP-Seq_T47D_Human0.76265507
137TCF3_18692474_ChIP-Seq_MEFs_Mouse0.74629550
138EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.73924148
139* FOXA2_19822575_ChIP-Seq_HepG2_Human0.73790094
140RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.72182107
141SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.71995273
142THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.70951575
143NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.70305126
144GATA2_19941826_ChIP-Seq_K562_Human0.69578416
145SMAD3_21741376_ChIP-Seq_HESCs_Human0.67503114

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008875_abnormal_xenobiotic_pharmacok4.94865126
2MP0005083_abnormal_biliary_tract4.68589620
3MP0010234_abnormal_vibrissa_follicle4.51558668
4MP0004043_abnormal_pH_regulation4.42579333
5MP0008004_abnormal_stomach_pH4.18677729
6MP0004782_abnormal_surfactant_physiolog3.77342647
7MP0002139_abnormal_hepatobiliary_system3.58513823
8MP0001958_emphysema3.29000137
9MP0000537_abnormal_urethra_morphology3.21615699
10MP0005248_abnormal_Harderian_gland3.16744091
11MP0001984_abnormal_olfaction3.01806594
12MP0005623_abnormal_meninges_morphology2.85318337
13MP0002132_abnormal_respiratory_system2.83965222
14MP0002254_reproductive_system_inflammat2.64395037
15MP0004133_heterotaxia2.60684262
16MP0003806_abnormal_nucleotide_metabolis2.45257057
17MP0004264_abnormal_extraembryonic_tissu2.44878700
18MP0003566_abnormal_cell_adhesion2.44178709
19MP0002909_abnormal_adrenal_gland2.34869665
20MP0001346_abnormal_lacrimal_gland2.15574522
21MP0010678_abnormal_skin_adnexa2.11909755
22MP0003186_abnormal_redox_activity2.10123123
23MP0003656_abnormal_erythrocyte_physiolo2.03533059
24MP0002138_abnormal_hepatobiliary_system2.01234780
25MP0010368_abnormal_lymphatic_system1.98271878
26MP0000566_synostosis1.96085180
27MP0010030_abnormal_orbit_morphology1.88895979
28MP0002277_abnormal_respiratory_mucosa1.84301835
29MP0005394_taste/olfaction_phenotype1.79252644
30MP0005499_abnormal_olfactory_system1.79252644
31MP0006054_spinal_hemorrhage1.78672516
32MP0004019_abnormal_vitamin_homeostasis1.72135236
33MP0002098_abnormal_vibrissa_morphology1.64345604
34MP0005377_hearing/vestibular/ear_phenot1.58402981
35MP0003878_abnormal_ear_physiology1.58402981
36MP0000762_abnormal_tongue_morphology1.56228958
37MP0005085_abnormal_gallbladder_physiolo1.56074828
38MP0002133_abnormal_respiratory_system1.54227507
39MP0005388_respiratory_system_phenotype1.54227507
40MP0010352_gastrointestinal_tract_polyps1.53412250
41MP0004272_abnormal_basement_membrane1.51049376
42MP0001849_ear_inflammation1.48813026
43MP0002877_abnormal_melanocyte_morpholog1.48552772
44MP0000383_abnormal_hair_follicle1.44945889
45MP0002295_abnormal_pulmonary_circulatio1.43932433
46MP0002796_impaired_skin_barrier1.42630226
47MP0005164_abnormal_response_to1.42169324
48MP0005408_hypopigmentation1.39861761
49MP0002234_abnormal_pharynx_morphology1.33784938
50MP0008995_early_reproductive_senescence1.33720673
51MP0001666_abnormal_nutrient_absorption1.32611151
52MP0001879_abnormal_lymphatic_vessel1.32557251
53MP0004883_abnormal_blood_vessel1.30128095
54MP0003453_abnormal_keratinocyte_physiol1.29057871
55MP0002160_abnormal_reproductive_system1.28624250
56MP0003303_peritoneal_inflammation1.27227442
57MP0005365_abnormal_bile_salt1.19650648
58MP0003191_abnormal_cellular_cholesterol1.18843465
59MP0005395_other_phenotype1.15193710
60MP0001664_abnormal_digestion1.14551709
61MP0000467_abnormal_esophagus_morphology1.14272108
62MP0005167_abnormal_blood-brain_barrier1.10330489
63MP0000627_abnormal_mammary_gland1.05521660
64MP0001177_atelectasis1.03388017
65MP0000858_altered_metastatic_potential1.03262930
66MP0000678_abnormal_parathyroid_gland1.01743125
67MP0002876_abnormal_thyroid_physiology0.99018302
68MP0002249_abnormal_larynx_morphology0.97105345
69MP0005166_decreased_susceptibility_to0.96476646
70MP0000470_abnormal_stomach_morphology0.96325875
71MP0009780_abnormal_chondrocyte_physiolo0.95547202
72MP0002060_abnormal_skin_morphology0.94418951
73MP0005275_abnormal_skin_tensile0.93974516
74MP0003075_altered_response_to0.93093640
75MP0003724_increased_susceptibility_to0.92942777
76MP0003950_abnormal_plasma_membrane0.92603987
77MP0001216_abnormal_epidermal_layer0.92368735
78MP0009379_abnormal_foot_pigmentation0.91593272
79MP0009764_decreased_sensitivity_to0.91387390
80MP0002282_abnormal_trachea_morphology0.89422703
81MP0000613_abnormal_salivary_gland0.88114844
82MP0002405_respiratory_system_inflammati0.86371587
83MP0005503_abnormal_tendon_morphology0.85958061
84MP0009643_abnormal_urine_homeostasis0.83689732
85MP0001881_abnormal_mammary_gland0.82694760
86MP0005165_increased_susceptibility_to0.81092714
87MP0001915_intracranial_hemorrhage0.81000045
88MP0009765_abnormal_xenobiotic_induced0.80646140
89MP0003300_gastrointestinal_ulcer0.79408958
90MP0010329_abnormal_lipoprotein_level0.78061736
91MP0003115_abnormal_respiratory_system0.77430116
92MP0005220_abnormal_exocrine_pancreas0.76891021
93MP0009053_abnormal_anal_canal0.76845476
94MP0000681_abnormal_thyroid_gland0.75505665
95MP0005023_abnormal_wound_healing0.73801183
96MP0000462_abnormal_digestive_system0.73352509
97MP0003690_abnormal_glial_cell0.73209681
98MP0002168_other_aberrant_phenotype0.72294835
99MP0009785_altered_susceptibility_to0.72215381
100MP0001765_abnormal_ion_homeostasis0.71655674
101MP0002136_abnormal_kidney_physiology0.71211116
102MP0005636_abnormal_mineral_homeostasis0.70958973
103MP0009763_increased_sensitivity_to0.70088698
104MP0010771_integument_phenotype0.68666429
105MP0003866_abnormal_defecation0.67974257
106MP0002653_abnormal_ependyma_morphology0.67805021
107MP0003045_fibrosis0.67583070
108MP0009384_cardiac_valve_regurgitation0.67435004
109MP0005310_abnormal_salivary_gland0.67140900
110MP0003705_abnormal_hypodermis_morpholog0.66306750
111MP0003828_pulmonary_edema0.65106279
112MP0001485_abnormal_pinna_reflex0.64570316
113MP0002233_abnormal_nose_morphology0.64255965
114MP0005387_immune_system_phenotype0.64128556
115MP0001790_abnormal_immune_system0.64128556
116MP0000249_abnormal_blood_vessel0.63118591
117MP0008789_abnormal_olfactory_epithelium0.62409951
118MP0001663_abnormal_digestive_system0.61761463
119MP0003941_abnormal_skin_development0.61662529
120MP0000465_gastrointestinal_hemorrhage0.60979969
121MP0003638_abnormal_response/metabolism_0.60518671
122MP0006082_CNS_inflammation0.58363488
123MP0005058_abnormal_lysosome_morphology0.58095264
124MP0001873_stomach_inflammation0.58033867
125MP0000377_abnormal_hair_follicle0.57694372
126MP0010155_abnormal_intestine_physiology0.57433034
127MP0005409_darkened_coat_color0.56275918
128MP0004484_altered_response_of0.55267027
129MP0002896_abnormal_bone_mineralization0.55057972
130MP0001175_abnormal_lung_morphology0.54974172
131MP0005501_abnormal_skin_physiology0.54913857
132MP0000343_altered_response_to0.54866992
133MP0001270_distended_abdomen0.51379847
134MP0002734_abnormal_mechanical_nocicepti0.50023505
135MP0001502_abnormal_circadian_rhythm0.44866440
136MP0000477_abnormal_intestine_morphology0.44807305
137MP0008873_increased_physiological_sensi0.44749266
138MP0005389_reproductive_system_phenotype0.44574625
139MP0002135_abnormal_kidney_morphology0.43245652

Predicted human phenotypes

RankGene SetZ-score
1Chronic bronchitis (HP:0004469)7.77593038
2Hyperactive renin-angiotensin system (HP:0000841)6.67661341
3Interstitial pulmonary disease (HP:0006530)6.06583420
4Renal salt wasting (HP:0000127)6.01062119
5Gout (HP:0001997)5.95126923
6Onycholysis (HP:0001806)5.85350728
7Tubulointerstitial nephritis (HP:0001970)5.14818383
8Tubulointerstitial fibrosis (HP:0005576)5.13434496
9Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.96733628
10Abnormal respiratory motile cilium physiology (HP:0012261)4.64571788
11Abnormal ciliary motility (HP:0012262)4.62842661
12Humeroradial synostosis (HP:0003041)4.50691893
13Synostosis involving the elbow (HP:0003938)4.50691893
14Recurrent sinusitis (HP:0011108)4.34552502
15Bronchomalacia (HP:0002780)4.22312026
16Abnormality of the nasal mucosa (HP:0000433)4.12613142
17Infertility (HP:0000789)4.12122507
18Right ventricular cardiomyopathy (HP:0011663)4.07088076
19Ulnar bowing (HP:0003031)4.06257901
20Tubular atrophy (HP:0000092)4.05723841
21Nasal polyposis (HP:0100582)4.01717710
22Rhinitis (HP:0012384)3.95734729
23Abnormal respiratory epithelium morphology (HP:0012253)3.95136654
24Abnormal respiratory motile cilium morphology (HP:0005938)3.95136654
25Recurrent otitis media (HP:0000403)3.92086241
26Male infertility (HP:0003251)3.87755698
27Bronchiectasis (HP:0002110)3.77322484
28Labial hypoplasia (HP:0000066)3.65348183
29Polycythemia (HP:0001901)3.52090538
30Milia (HP:0001056)3.47796324
31Bronchitis (HP:0012387)3.44986413
32Hyperaldosteronism (HP:0000859)3.41443493
33Fragile nails (HP:0001808)3.38935672
34Hyperkalemia (HP:0002153)3.35176698
35Hypoplastic female external genitalia (HP:0012815)3.33641419
36Tubulointerstitial abnormality (HP:0001969)3.31771488
37Abnormality of chloride homeostasis (HP:0011422)3.26532735
38Occipital encephalocele (HP:0002085)3.22818001
39Atrophic scars (HP:0001075)3.04910201
40Glomerulosclerosis (HP:0000096)2.98666389
41Atelectasis (HP:0100750)2.96840495
42Pustule (HP:0200039)2.96402573
43Pancreatic fibrosis (HP:0100732)2.95038764
44True hermaphroditism (HP:0010459)2.92641867
45Alopecia of scalp (HP:0002293)2.89966648
46Dynein arm defect of respiratory motile cilia (HP:0012255)2.87917211
47Absent/shortened dynein arms (HP:0200106)2.87917211
48Stenosis of the external auditory canal (HP:0000402)2.87560554
49Hypotension (HP:0002615)2.82130163
50Bowed forearm bones (HP:0003956)2.73146433
51Bowing of the arm (HP:0006488)2.73146433
52Abnormal hemoglobin (HP:0011902)2.71842022
53Abnormality of renin-angiotensin system (HP:0000847)2.69709323
54Hyperuricemia (HP:0002149)2.65373921
55Increased purine levels (HP:0004368)2.65373921
56Bifid scrotum (HP:0000048)2.55726679
57Abnormality of the labia (HP:0000058)2.50128856
58Cystic liver disease (HP:0006706)2.48745373
59Vascular calcification (HP:0004934)2.44243136
60Curly hair (HP:0002212)2.42147653
61Molar tooth sign on MRI (HP:0002419)2.41403877
62Abnormality of midbrain morphology (HP:0002418)2.41403877
63Chronic hepatic failure (HP:0100626)2.39570480
64Hypoplasia of dental enamel (HP:0006297)2.34454506
65Pancreatic cysts (HP:0001737)2.34262364
66Nephronophthisis (HP:0000090)2.32029616
67Plantar hyperkeratosis (HP:0007556)2.31995253
68Choroideremia (HP:0001139)2.29094783
69Vaginal fistula (HP:0004320)2.28597672
70Split foot (HP:0001839)2.28404307
71Abnormal blistering of the skin (HP:0008066)2.28370581
72Pili torti (HP:0003777)2.25857751
73Abnormality of renal excretion (HP:0011036)2.22892854
74Cardiovascular calcification (HP:0011915)2.20850258
75Esophageal atresia (HP:0002032)2.16911922
76Abnormality of the renal cortex (HP:0011035)2.16893105
77Hypokalemic alkalosis (HP:0001949)2.15502440
78Subacute progressive viral hepatitis (HP:0006572)2.15325509
79Abnormality of the distal phalanges of the toes (HP:0010182)2.14657311
80Aplasia involving bones of the upper limbs (HP:0009823)2.10240952
81Aplasia of the phalanges of the hand (HP:0009802)2.10240952
82Aplasia involving bones of the extremities (HP:0009825)2.10240952
83Hyponatremia (HP:0002902)2.08556177
84Postaxial foot polydactyly (HP:0001830)2.08265758
85Respiratory distress (HP:0002098)2.08207921
86Decreased circulating renin level (HP:0003351)2.05173467
87Choanal stenosis (HP:0000452)2.04517035
88Abnormality of purine metabolism (HP:0004352)2.04022402
89Esophageal varix (HP:0002040)2.03978479
90Chronic sinusitis (HP:0011109)2.02473436
91Chronic otitis media (HP:0000389)2.02294061
92Scanning speech (HP:0002168)2.01610246
93Micronodular cirrhosis (HP:0001413)2.00193797
94Stomach cancer (HP:0012126)1.99764962
95Abnormality of cochlea (HP:0000375)1.99721727
96Hypoplastic labia majora (HP:0000059)1.99007131
97Recurrent bronchitis (HP:0002837)1.98675583
98Rectal prolapse (HP:0002035)1.97575309
99Arterial tortuosity (HP:0005116)1.94311299
100Bell-shaped thorax (HP:0001591)1.94229423
101Abnormality of the renal medulla (HP:0100957)1.92774772
102Abnormality of sodium homeostasis (HP:0010931)1.81118312
103Stage 5 chronic kidney disease (HP:0003774)1.80530603
104Woolly hair (HP:0002224)1.79319607
105Femoral bowing (HP:0002980)1.79051017
106Absent frontal sinuses (HP:0002688)1.78482565
107Tachypnea (HP:0002789)1.78221863
108Vascular tortuosity (HP:0004948)1.78208458
109Congenital hepatic fibrosis (HP:0002612)1.77736209
110Abnormality of monocarboxylic acid metabolism (HP:0010996)1.77170639
111Distal lower limb muscle weakness (HP:0009053)1.74579880
112Male pseudohermaphroditism (HP:0000037)1.74395250
113Osteolytic defects of the hand bones (HP:0009699)1.74057493
114Osteolytic defects of the phalanges of the hand (HP:0009771)1.74057493
115Abnormality of the labia majora (HP:0012881)1.73260425
116Adrenal overactivity (HP:0002717)1.71022641
117Buphthalmos (HP:0000557)1.66886550
118Hoarse voice (HP:0001609)1.65668920
119Nephropathy (HP:0000112)1.64933663
120Short nail (HP:0001799)1.64743005
121Nail dystrophy (HP:0008404)1.64680398
122Aplasia/Hypoplasia of the tongue (HP:0010295)1.64321580
123Dehydration (HP:0001944)1.63904556
124Anencephaly (HP:0002323)1.62350513
125Medial flaring of the eyebrow (HP:0010747)1.56684563
126Aplasia/Hypoplasia of the spleen (HP:0010451)1.55823296
127Furrowed tongue (HP:0000221)1.53761110
128Lip pit (HP:0100267)1.53644463
129Asplenia (HP:0001746)1.50124147
130Absent rod-and cone-mediated responses on ERG (HP:0007688)1.48696031
131Congenital primary aphakia (HP:0007707)1.48000180
132Gait imbalance (HP:0002141)1.43047405
133Oculomotor apraxia (HP:0000657)1.41161420
134Cone-rod dystrophy (HP:0000548)1.41055103
135Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.40191486
136Popliteal pterygium (HP:0009756)1.39733809
137Abnormality of permanent molar morphology (HP:0011071)1.37732410
138Abnormality of the dental root (HP:0006486)1.37732410
139Taurodontia (HP:0000679)1.37732410
140Postaxial hand polydactyly (HP:0001162)1.28859140
141Sclerocornea (HP:0000647)1.28664166
142Glucose intolerance (HP:0000833)1.28594597
143Nephrogenic diabetes insipidus (HP:0009806)1.27140484
144Abnormality of molar morphology (HP:0011070)1.26584476
145Abnormality of molar (HP:0011077)1.26584476
146Median cleft lip (HP:0000161)1.26320825
147Abnormality of the dental pulp (HP:0006479)1.25565762
148Hand muscle atrophy (HP:0009130)1.19221695
149Short thorax (HP:0010306)1.18382658
150Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.13094363
151Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.12056432
152Abnormality of the frontal sinuses (HP:0002687)1.11513335
153Obstructive sleep apnea (HP:0002870)1.11128114
154Flat acetabular roof (HP:0003180)1.06189234
155Fetal akinesia sequence (HP:0001989)1.02758494
156Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.02742704
157Decreased central vision (HP:0007663)1.01933412
158Aplasia of the musculature (HP:0100854)1.01432605
159Preaxial hand polydactyly (HP:0001177)1.00865700
160Spinal muscular atrophy (HP:0007269)1.00831945
161Limb-girdle muscle atrophy (HP:0003797)0.98709572

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA26.22221399
2MST44.91835039
3ERBB33.64818591
4MST1R3.08137646
5DAPK23.03039324
6MAP3K23.02089140
7FER2.96268458
8EPHB12.87043791
9EPHB22.80485051
10MAP3K32.59763119
11EPHA32.56908913
12TRPM72.51809944
13SMG12.24237531
14LRRK22.03865545
15TGFBR22.01664240
16ZAP701.83237329
17MAP3K121.73014570
18PAK41.71698517
19FGFR21.67101890
20PTK21.64283138
21EEF2K1.59230971
22TTK1.54093210
23STK101.49274778
24CSK1.48395190
25TESK11.44771461
26LMTK21.43853891
27FRK1.37932466
28FGFR41.37611597
29RPS6KB21.32798913
30PTK61.29384905
31TRIB31.28926253
32PDGFRB1.28846082
33MET1.25768975
34NEK61.24824321
35MAPK151.11256785
36ERBB21.06476015
37LATS11.05370513
38MAP3K71.04053363
39NEK91.03358567
40MAP2K11.02441069
41RIPK10.97240536
42FGFR30.96494549
43MARK20.95292657
44TIE10.94012648
45MAP2K20.92814218
46CDK60.90013949
47MYLK0.89936947
48MAP3K10.86352287
49MAP3K90.86177696
50STK380.84438089
51WNK40.84226649
52TEC0.82647995
53RIPK40.82612869
54STK390.81854246
55ICK0.77452159
56LIMK10.76074612
57ITK0.74352187
58ERBB40.73708205
59ERN10.73311717
60PBK0.72795933
61BCR0.71702943
62TGFBR10.70362972
63BRSK20.69224808
64STK30.69185721
65TLK10.64623218
66PDK20.63596379
67GRK10.63528918
68STK160.63488705
69EGFR0.62103738
70PNCK0.61809961
71MATK0.60654956
72STK240.59461553
73CAMKK10.59429189
74BMX0.56244142
75PRKD10.55369297
76HIPK20.55089443
77PRKCI0.54700003
78IGF1R0.54187340
79CDC42BPA0.53893086
80CDK190.52806589
81KSR20.51642344
82SRC0.51024960
83MAP2K30.50368621
84FGFR10.50248169
85NLK0.48205260
86ILK0.46488641
87TYK20.45177577
88PDPK10.44723481
89PAK30.44286106
90PRKAA20.44207468
91DAPK10.43453935
92MAP3K110.42969213
93NME10.42142622
94GRK60.42094474
95DAPK30.41069464
96PRKCE0.40954944
97ROCK20.39191157
98SGK30.38662959
99PRKCQ0.38503568
100PKN20.38075885
101KSR10.36586276
102TAOK10.36512020
103SGK10.36412144
104PRKG20.35953767
105ALK0.35867558
106ABL10.33084157
107CAMK2G0.32639341
108PRKCD0.31124053
109SGK2230.30511621
110SGK4940.30511621
111OXSR10.30483994
112IRAK10.29795515
113TBK10.29341989
114AURKA0.27520158
115JAK10.27242367
116RET0.26681627
117BMPR1B0.26330073
118MAPKAPK30.26027932
119SGK20.25519032
120IKBKE0.24854953
121STK38L0.24623210
122RPS6KA20.24441736
123PDK40.24223100
124PDK30.24223100
125AKT20.23497653
126DYRK1B0.23270945
127PTK2B0.23209088
128MAP3K60.22585803
129ROCK10.20948568
130MAPKAPK50.19830641
131FYN0.19659565
132PRKCA0.19481506
133YES10.13806590
134PRKACA0.13284966
135ADRBK10.12605166
136BMPR20.12349306
137DMPK0.11484877
138PAK10.10863350
139ABL20.09962992

Predicted pathways (KEGG)

RankGene SetZ-score
1Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009805.83260790
2Drug metabolism - cytochrome P450_Homo sapiens_hsa009825.56559500
3Chemical carcinogenesis_Homo sapiens_hsa052044.80211488
4Glutathione metabolism_Homo sapiens_hsa004803.71469715
5Histidine metabolism_Homo sapiens_hsa003402.75346506
6Phenylalanine metabolism_Homo sapiens_hsa003602.45157905
7Sulfur metabolism_Homo sapiens_hsa009202.42689271
8Retinol metabolism_Homo sapiens_hsa008302.35264061
9Tyrosine metabolism_Homo sapiens_hsa003502.24728000
10Caffeine metabolism_Homo sapiens_hsa002322.02801564
11Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.93160080
12Huntingtons disease_Homo sapiens_hsa050161.85477202
13beta-Alanine metabolism_Homo sapiens_hsa004101.71493655
14Steroid hormone biosynthesis_Homo sapiens_hsa001401.67795935
15Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.60364333
16Mineral absorption_Homo sapiens_hsa049781.60220708
17Sphingolipid metabolism_Homo sapiens_hsa006001.57448221
18Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.47646914
19Linoleic acid metabolism_Homo sapiens_hsa005911.47303280
20Tight junction_Homo sapiens_hsa045301.44949325
21Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.44518633
22Adherens junction_Homo sapiens_hsa045201.43908893
23ECM-receptor interaction_Homo sapiens_hsa045121.42699553
24Fatty acid degradation_Homo sapiens_hsa000711.28810578
25Bladder cancer_Homo sapiens_hsa052191.28311094
26Leukocyte transendothelial migration_Homo sapiens_hsa046701.19136759
27Gastric acid secretion_Homo sapiens_hsa049711.18348810
28Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.14901221
29Vibrio cholerae infection_Homo sapiens_hsa051101.14564202
30Salivary secretion_Homo sapiens_hsa049701.12557577
31ABC transporters_Homo sapiens_hsa020101.12381076
32Sulfur relay system_Homo sapiens_hsa041221.09567465
33Collecting duct acid secretion_Homo sapiens_hsa049661.07509484
34Circadian rhythm_Homo sapiens_hsa047100.98840533
35Starch and sucrose metabolism_Homo sapiens_hsa005000.97331945
36Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.96930882
37Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.95808392
38Pancreatic secretion_Homo sapiens_hsa049720.91536256
39Hippo signaling pathway_Homo sapiens_hsa043900.90887611
40Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.88746705
41Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.84210839
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.82145237
43AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.81915440
44Proteoglycans in cancer_Homo sapiens_hsa052050.80145856
45Amoebiasis_Homo sapiens_hsa051460.79225820
46Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.78459956
47Phagosome_Homo sapiens_hsa041450.77983223
48Thyroid hormone synthesis_Homo sapiens_hsa049180.77880472
49Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.77786930
50Pentose and glucuronate interconversions_Homo sapiens_hsa000400.76405170
51Carbohydrate digestion and absorption_Homo sapiens_hsa049730.75480917
52Drug metabolism - other enzymes_Homo sapiens_hsa009830.75418573
53Focal adhesion_Homo sapiens_hsa045100.74762409
54Pertussis_Homo sapiens_hsa051330.72367568
55Thyroid cancer_Homo sapiens_hsa052160.71796664
56Lysosome_Homo sapiens_hsa041420.69276938
57Complement and coagulation cascades_Homo sapiens_hsa046100.68027351
58Toxoplasmosis_Homo sapiens_hsa051450.67945903
59Notch signaling pathway_Homo sapiens_hsa043300.64585581
60Arachidonic acid metabolism_Homo sapiens_hsa005900.64536315
61Renal cell carcinoma_Homo sapiens_hsa052110.63237183
62Small cell lung cancer_Homo sapiens_hsa052220.60196797
63Salmonella infection_Homo sapiens_hsa051320.60136118
64Fatty acid biosynthesis_Homo sapiens_hsa000610.57527583
65Hepatitis C_Homo sapiens_hsa051600.56548439
66Choline metabolism in cancer_Homo sapiens_hsa052310.54564909
67Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.48548659
68Hematopoietic cell lineage_Homo sapiens_hsa046400.47042365
69Glycerophospholipid metabolism_Homo sapiens_hsa005640.46847910
70Bile secretion_Homo sapiens_hsa049760.46709692
71Malaria_Homo sapiens_hsa051440.45640200
72TGF-beta signaling pathway_Homo sapiens_hsa043500.45456880
73Pancreatic cancer_Homo sapiens_hsa052120.42400153
74Viral myocarditis_Homo sapiens_hsa054160.40583871
75Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.40545339
76Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.40341636
77Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.40292113
78Axon guidance_Homo sapiens_hsa043600.39392090
79Regulation of actin cytoskeleton_Homo sapiens_hsa048100.39354300
80Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.39046627
81Rheumatoid arthritis_Homo sapiens_hsa053230.38387927
82Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.38150105
83Shigellosis_Homo sapiens_hsa051310.37597538
84Other glycan degradation_Homo sapiens_hsa005110.36878980
85Endometrial cancer_Homo sapiens_hsa052130.36627006
86Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.34981018
87Type I diabetes mellitus_Homo sapiens_hsa049400.34597462
88Pathways in cancer_Homo sapiens_hsa052000.33395569
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.32871655
90Pentose phosphate pathway_Homo sapiens_hsa000300.32190872
91Allograft rejection_Homo sapiens_hsa053300.31460970
92PPAR signaling pathway_Homo sapiens_hsa033200.30676241
93Taste transduction_Homo sapiens_hsa047420.30332835
94Rap1 signaling pathway_Homo sapiens_hsa040150.30287298
95Glycerolipid metabolism_Homo sapiens_hsa005610.30134377
96Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.30119070
97Asthma_Homo sapiens_hsa053100.29801962
98Glycosaminoglycan degradation_Homo sapiens_hsa005310.29750406
99Autoimmune thyroid disease_Homo sapiens_hsa053200.29244453
100Dilated cardiomyopathy_Homo sapiens_hsa054140.28456446
101Cysteine and methionine metabolism_Homo sapiens_hsa002700.28078911
102TNF signaling pathway_Homo sapiens_hsa046680.27810516
103Staphylococcus aureus infection_Homo sapiens_hsa051500.27062651
104Peroxisome_Homo sapiens_hsa041460.26760920
105Leishmaniasis_Homo sapiens_hsa051400.25976009
106Graft-versus-host disease_Homo sapiens_hsa053320.25442296
107Vitamin digestion and absorption_Homo sapiens_hsa049770.24798503
108Protein digestion and absorption_Homo sapiens_hsa049740.24443531
109Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.24176047
110Basal cell carcinoma_Homo sapiens_hsa052170.23897754
111Endocytosis_Homo sapiens_hsa041440.23498344
112Arginine and proline metabolism_Homo sapiens_hsa003300.23377435
113Tryptophan metabolism_Homo sapiens_hsa003800.23059541
114VEGF signaling pathway_Homo sapiens_hsa043700.22991595
115Chronic myeloid leukemia_Homo sapiens_hsa052200.22632934
116Cyanoamino acid metabolism_Homo sapiens_hsa004600.22111436
117Jak-STAT signaling pathway_Homo sapiens_hsa046300.22059197
118Metabolic pathways_Homo sapiens_hsa011000.21988455
119Antigen processing and presentation_Homo sapiens_hsa046120.19588150
120Insulin resistance_Homo sapiens_hsa049310.19575824
121Influenza A_Homo sapiens_hsa051640.19476821
122alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.19353384
123Platelet activation_Homo sapiens_hsa046110.19133487
124Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.18859315
125Intestinal immune network for IgA production_Homo sapiens_hsa046720.18603891
126Legionellosis_Homo sapiens_hsa051340.18411595
127N-Glycan biosynthesis_Homo sapiens_hsa005100.18365114
128Primary bile acid biosynthesis_Homo sapiens_hsa001200.18212082
129Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.18110442
130Sphingolipid signaling pathway_Homo sapiens_hsa040710.17722940
131Fatty acid metabolism_Homo sapiens_hsa012120.17511888
132Melanogenesis_Homo sapiens_hsa049160.17076038
133Propanoate metabolism_Homo sapiens_hsa006400.17055166
134Ether lipid metabolism_Homo sapiens_hsa005650.17037017
135Hedgehog signaling pathway_Homo sapiens_hsa043400.16525381
136Melanoma_Homo sapiens_hsa052180.16247873
137Adipocytokine signaling pathway_Homo sapiens_hsa049200.15985910
138Transcriptional misregulation in cancer_Homo sapiens_hsa052020.14953895
139Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.13922847
140Cocaine addiction_Homo sapiens_hsa050300.13833902
141Prostate cancer_Homo sapiens_hsa052150.12083570
142Ovarian steroidogenesis_Homo sapiens_hsa049130.12033769
143Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.11259769
144Fructose and mannose metabolism_Homo sapiens_hsa000510.10229937
145Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.10147070
146Phosphatidylinositol signaling system_Homo sapiens_hsa040700.10011872
147Olfactory transduction_Homo sapiens_hsa047400.09694218
148Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.08831020

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