CXCL3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of chemokine biosynthetic process (GO:0045080)6.07262786
2hydrogen peroxide biosynthetic process (GO:0050665)6.02551484
3neutrophil activation involved in immune response (GO:0002283)5.86843936
4response to peptidoglycan (GO:0032494)5.74905275
5reactive oxygen species biosynthetic process (GO:1903409)5.35255136
6positive regulation of heterotypic cell-cell adhesion (GO:0034116)5.31843855
7regulation of chemokine biosynthetic process (GO:0045073)5.17565987
8superoxide anion generation (GO:0042554)5.12355674
9lipopolysaccharide-mediated signaling pathway (GO:0031663)4.99824985
10positive regulation of heat generation (GO:0031652)4.92894645
11respiratory burst (GO:0045730)4.89827493
12regulation of fever generation (GO:0031620)4.88558609
13positive regulation of cellular amide metabolic process (GO:0034250)4.79481834
14modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.79016452
15positive regulation by organism of defense response of other organism involved in symbiotic interact4.79016452
16modulation by symbiont of host immune response (GO:0052553)4.79016452
17positive regulation by symbiont of host defense response (GO:0052509)4.79016452
18modulation by symbiont of host defense response (GO:0052031)4.79016452
19modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.79016452
20granulocyte activation (GO:0036230)4.70357760
21antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.58667848
22regulation of cytokine secretion involved in immune response (GO:0002739)4.50030994
23positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)4.46367158
24positive regulation of mast cell activation involved in immune response (GO:0033008)4.41351683
25positive regulation of mast cell degranulation (GO:0043306)4.41351683
26immunoglobulin mediated immune response (GO:0016064)4.35374401
27production of molecular mediator involved in inflammatory response (GO:0002532)4.32916943
28neutrophil activation (GO:0042119)4.32788328
29positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)4.29070495
30regulation of membrane protein ectodomain proteolysis (GO:0051043)4.12400793
31macrophage activation involved in immune response (GO:0002281)4.01451478
32leukocyte aggregation (GO:0070486)4.01174327
33positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.96547068
34regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.93734535
35regulation of chronic inflammatory response (GO:0002676)3.92236717
36positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.90205206
37regulation of vitamin D biosynthetic process (GO:0060556)3.89926492
38eosinophil chemotaxis (GO:0048245)3.86422078
39regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.86065627
40positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.77861856
41cellular response to zinc ion (GO:0071294)3.77500369
42response to muramyl dipeptide (GO:0032495)3.76861925
43positive regulation of interferon-alpha production (GO:0032727)3.74180308
44regulation of heterotypic cell-cell adhesion (GO:0034114)3.71334346
45regulation of heat generation (GO:0031650)3.68891984
46positive regulation of mast cell activation (GO:0033005)3.68252480
47positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.65969645
48negative regulation of lipid storage (GO:0010888)3.64646865
49regulation of mast cell degranulation (GO:0043304)3.63226611
50negative regulation of myeloid cell apoptotic process (GO:0033033)3.62680790
51regulation of podosome assembly (GO:0071801)3.58686631
52regulation of mononuclear cell migration (GO:0071675)3.57985209
53regulation of interferon-alpha production (GO:0032647)3.55125128
54negative regulation of cytokine production involved in immune response (GO:0002719)3.54922790
55detection of molecule of bacterial origin (GO:0032490)3.54309812
56NIK/NF-kappaB signaling (GO:0038061)3.53188532
57positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.53099648
58positive regulation of nitric oxide biosynthetic process (GO:0045429)3.51987527
59negative regulation of nitric oxide biosynthetic process (GO:0045019)3.49805798
60cellular response to lipopolysaccharide (GO:0071222)3.49288499
61negative regulation of interleukin-12 production (GO:0032695)3.49177839
62response to protozoan (GO:0001562)3.47788590
63regulation of T-helper 1 cell differentiation (GO:0045625)3.46961401
64monocyte chemotaxis (GO:0002548)3.46366802
65regulation of vitamin metabolic process (GO:0030656)3.45511502
66eosinophil migration (GO:0072677)3.42254250
67regulation of mast cell activation involved in immune response (GO:0033006)3.38213490
68myeloid cell activation involved in immune response (GO:0002275)3.37214707
69regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.36561349
70cellular response to molecule of bacterial origin (GO:0071219)3.35249064
71positive regulation of leukocyte degranulation (GO:0043302)3.34471185
72cellular response to nicotine (GO:0071316)3.33779840
73regulation of vascular endothelial growth factor production (GO:0010574)3.32071025
74positive regulation of chemokine production (GO:0032722)3.30549571
75response to manganese ion (GO:0010042)3.30338615
76glycosphingolipid catabolic process (GO:0046479)3.29958157
77regulation of NF-kappaB import into nucleus (GO:0042345)3.29820073
78macrophage activation (GO:0042116)3.28597210
79positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.26997014
80B cell mediated immunity (GO:0019724)3.26208228
81positive regulation of acute inflammatory response (GO:0002675)3.24101815
82regulation of dendritic cell antigen processing and presentation (GO:0002604)3.23746369
83germinal center formation (GO:0002467)3.23170092
84branching involved in labyrinthine layer morphogenesis (GO:0060670)3.22252328
85positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.22185739
86regulation of mast cell activation (GO:0033003)3.21510019
87oligosaccharide catabolic process (GO:0009313)3.21383718
88defense response to protozoan (GO:0042832)3.20388043
89negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.17017749
90regulation of T-helper 2 cell differentiation (GO:0045628)3.16033380
91negative regulation of interleukin-17 production (GO:0032700)3.15008813
92interferon-gamma-mediated signaling pathway (GO:0060333)3.14529487
93low-density lipoprotein particle clearance (GO:0034383)3.13515390
94positive regulation of type 2 immune response (GO:0002830)3.13333853
95regulation of prostaglandin secretion (GO:0032306)3.12988068
96regulation of immunoglobulin secretion (GO:0051023)3.11274286
97response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.10845929
98response to host immune response (GO:0052572)3.10845929
99activation of MAPKKK activity (GO:0000185)3.10381196
100regulation of lymphocyte chemotaxis (GO:1901623)3.10231872
101positive regulation of humoral immune response (GO:0002922)3.09942010
102positive regulation of NF-kappaB import into nucleus (GO:0042346)3.09646813
103positive regulation of prostaglandin secretion (GO:0032308)3.09219302
104T-helper 1 type immune response (GO:0042088)3.05415342
105natural killer cell mediated immunity (GO:0002228)3.04398809
106natural killer cell mediated cytotoxicity (GO:0042267)3.04398809
107positive regulation of interleukin-6 production (GO:0032755)3.03645089
108phagosome maturation (GO:0090382)3.03175466
109regulation of nitric oxide biosynthetic process (GO:0045428)3.02932763
110cellular response to thyroid hormone stimulus (GO:0097067)3.00525533
111positive regulation of transcription factor import into nucleus (GO:0042993)3.00216403
112regulation of interleukin-8 biosynthetic process (GO:0045414)2.98060697
113positive regulation of lymphocyte migration (GO:2000403)2.97871650
114lymphocyte chemotaxis (GO:0048247)2.97334924
115negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.96063643
116modulation of growth of symbiont involved in interaction with host (GO:0044144)2.96063643
117regulation of growth of symbiont in host (GO:0044126)2.96063643
118negative regulation of growth of symbiont in host (GO:0044130)2.96063643
119glycolipid catabolic process (GO:0019377)2.94484073
120regulation of interleukin-2 biosynthetic process (GO:0045076)2.93921324
121myeloid dendritic cell differentiation (GO:0043011)2.93231295
122regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.91497219
123cytokine secretion (GO:0050663)2.90425183
124cellular response to biotic stimulus (GO:0071216)2.90405906
125positive regulation of cytokine biosynthetic process (GO:0042108)2.90095271
126regulation of interferon-beta biosynthetic process (GO:0045357)2.89512679
127negative regulation of production of molecular mediator of immune response (GO:0002701)2.88868959
128regulation of interleukin-6 production (GO:0032675)2.87724696
129positive regulation of interleukin-12 production (GO:0032735)2.87360506
130microglial cell activation (GO:0001774)2.86826107
131negative regulation of glucose transport (GO:0010829)2.85841466
132regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.84606350
133positive regulation vascular endothelial growth factor production (GO:0010575)2.83814814
134positive regulation of T-helper cell differentiation (GO:0045624)2.81339483
135cellular extravasation (GO:0045123)2.79731096
136regulation of macrophage chemotaxis (GO:0010758)2.76776963
137regulation of interleukin-12 production (GO:0032655)2.74445223
138decidualization (GO:0046697)2.71617258
139regulation of inflammatory response to antigenic stimulus (GO:0002861)2.71550261
140positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.68753131
141positive regulation of gamma-delta T cell activation (GO:0046645)2.66959726
142type I interferon signaling pathway (GO:0060337)2.66382813

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human9.57194426
2IRF8_21731497_ChIP-ChIP_J774_Mouse7.06505982
3IRF8_22096565_ChIP-ChIP_GC-B_Human6.50394836
4IRF8_27001747_Chip-Seq_BMDM_Mouse4.24117438
5Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse4.16365327
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.98791058
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.96204581
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.81978218
9* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.62740648
10* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.50450215
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.05066899
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.86364423
13MYB_21317192_ChIP-Seq_ERMYB_Mouse2.71995905
14* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.71596107
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.56014902
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.46619347
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.39179491
18SMAD_19615063_ChIP-ChIP_OVARY_Human2.32261069
19STAT4_19710469_ChIP-ChIP_TH1__Mouse2.30643168
20STAT6_21828071_ChIP-Seq_BEAS2B_Human2.28167327
21STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.86290506
22VDR_24787735_ChIP-Seq_THP-1_Human1.85168660
23PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.83082202
24NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.82048255
25SPI1_23547873_ChIP-Seq_NB4_Human1.71572965
26CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.70158272
27VDR_21846776_ChIP-Seq_THP-1_Human1.68603944
28GATA1_22025678_ChIP-Seq_K562_Human1.63218309
29CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.62324235
30BRD4_27068464_Chip-Seq_AML-cells_Mouse1.62084840
31PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.61435885
32ESR2_21235772_ChIP-Seq_MCF-7_Human1.60832639
33IKZF1_21737484_ChIP-ChIP_HCT116_Human1.55664798
34NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.55545860
35THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.54845455
36PU_27001747_Chip-Seq_BMDM_Mouse1.50857991
37ELK3_25401928_ChIP-Seq_HUVEC_Human1.50641688
38TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.48566220
39NRF2_20460467_ChIP-Seq_MEFs_Mouse1.48232011
40NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.48232011
41VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.44138167
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42626219
43CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.38940973
44RUNX_20019798_ChIP-Seq_JUKART_Human1.38110842
45KDM2B_26808549_Chip-Seq_SUP-B15_Human1.37816172
46VDR_24763502_ChIP-Seq_THP-1_Human1.36667558
47CDX2_19796622_ChIP-Seq_MESCs_Mouse1.35099044
48TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.34698171
49TP63_17297297_ChIP-ChIP_HaCaT_Human1.31803790
50CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.29973700
51RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.25541675
52GATA1_19941826_ChIP-Seq_K562_Human1.24532859
53ESR1_21235772_ChIP-Seq_MCF-7_Human1.23948460
54PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21723911
55CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.19991017
56STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.17521764
57SPI1_23127762_ChIP-Seq_K562_Human1.16089586
58MYB_26560356_Chip-Seq_TH2_Human1.14328200
59TCF7_22412390_ChIP-Seq_EML_Mouse1.12243767
60SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11957902
61LXR_22292898_ChIP-Seq_THP-1_Human1.09515868
62CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.08765159
63ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.06499295
64MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.05309012
65GATA1_19941827_ChIP-Seq_MEL_Mouse1.04534498
66RUNX1_22412390_ChIP-Seq_EML_Mouse1.04483641
67GATA3_26560356_Chip-Seq_TH2_Human1.01334664
68KDM2B_26808549_Chip-Seq_DND41_Human0.99883660
69FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.98940487
70PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.98361168
71PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97286133
72UTX_26944678_Chip-Seq_JUKART_Human0.96951769
73LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.96857407
74LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.96598767
75KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.96158106
76NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.95382691
77TFEB_21752829_ChIP-Seq_HELA_Human0.95181688
78SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.94789711
79KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.94240105
80KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.94240105
81KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.94240105
82GATA2_21666600_ChIP-Seq_HMVEC_Human0.93498757
83TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92246086
84RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91907601
85STAT1_20625510_ChIP-Seq_HELA_Human0.91803969
86CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.90445430
87CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.90039017
88SCL_19346495_ChIP-Seq_HPC-7_Human0.89614175
89FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.88506446
90* SOX2_20726797_ChIP-Seq_SW620_Human0.87963677
91BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.86195095
92CLOCK_20551151_ChIP-Seq_293T_Human0.85902375
93* GATA3_27048872_Chip-Seq_THYMUS_Human0.84725635
94RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.83211030
95UBF1/2_26484160_Chip-Seq_HMECs_Human0.82582803
96MAF_26560356_Chip-Seq_TH1_Human0.82076381
97GATA1_22383799_ChIP-Seq_G1ME_Mouse0.81961690
98GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.80164088
99CJUN_26792858_Chip-Seq_BT549_Human0.79994955
100SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.76735335
101* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.76102712
102MYB_26560356_Chip-Seq_TH1_Human0.76075293
103EGR1_19032775_ChIP-ChIP_M12_Human0.75493676
104* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.74382685
105SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.73784056
106SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.73784056
107TRIM28_21343339_ChIP-Seq_HEK293_Human0.73044847
108FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.70735766
109EGR1_23403033_ChIP-Seq_LIVER_Mouse0.70284922
110GATA2_22383799_ChIP-Seq_G1ME_Mouse0.70136602
111TP53_18474530_ChIP-ChIP_U2OS_Human0.69762720
112RARG_19884340_ChIP-ChIP_MEFs_Mouse0.66025359
113ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.65686472
114TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.63034176
115CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.62366582
116P63_26484246_Chip-Seq_KERATINOCYTES_Human0.62086125
117E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.56996409
118SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.56974366
119SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.55988538
120RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.52702793
121PU1_27457419_Chip-Seq_LIVER_Mouse0.52611684
122CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.52321512
123SMRT_27268052_Chip-Seq_Bcells_Human0.50054885
124RXR_22108803_ChIP-Seq_LS180_Human0.49193040
125GATA2_19941826_ChIP-Seq_K562_Human0.48408448
126CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.47953605

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to4.66389082
2MP0009785_altered_susceptibility_to4.60401507
3MP0001835_abnormal_antigen_presentation4.42354955
4MP0002148_abnormal_hypersensitivity_rea4.08190782
5MP0002419_abnormal_innate_immunity3.59250452
6MP0003724_increased_susceptibility_to3.52882358
7MP0005000_abnormal_immune_tolerance3.51804392
8MP0006082_CNS_inflammation3.45942085
9MP0003303_peritoneal_inflammation3.26075028
10MP0005025_abnormal_response_to3.23782040
11MP0009840_abnormal_foam_cell3.05150788
12MP0005671_abnormal_response_to2.65861913
13MP0009764_decreased_sensitivity_to2.63725329
14MP0002452_abnormal_antigen_presenting2.60072143
15MP0004510_myositis2.57157429
16MP0002139_abnormal_hepatobiliary_system2.47326855
17MP0002723_abnormal_immune_serum2.46229339
18MP0001790_abnormal_immune_system2.42704309
19MP0005387_immune_system_phenotype2.42704309
20MP0003195_calcinosis2.42527633
21MP0001533_abnormal_skeleton_physiology2.40738299
22MP0003300_gastrointestinal_ulcer2.31391529
23MP0000685_abnormal_immune_system2.24811324
24MP0001800_abnormal_humoral_immune2.22509556
25MP0005167_abnormal_blood-brain_barrier2.15696195
26MP0001819_abnormal_immune_cell2.12115561
27MP0002420_abnormal_adaptive_immunity2.09504447
28MP0003646_muscle_fatigue2.06690389
29MP0003075_altered_response_to2.05476512
30MP0002006_tumorigenesis2.03905941
31MP0001845_abnormal_inflammatory_respons1.99967074
32MP0005464_abnormal_platelet_physiology1.98876711
33MP0004947_skin_inflammation1.98824472
34MP0001853_heart_inflammation1.95354435
35MP0002405_respiratory_system_inflammati1.94193120
36MP0003448_altered_tumor_morphology1.88504657
37MP0005058_abnormal_lysosome_morphology1.88089787
38MP0003186_abnormal_redox_activity1.87888614
39MP0009278_abnormal_bone_marrow1.84610708
40MP0000343_altered_response_to1.76994823
41MP0008469_abnormal_protein_level1.76819039
42MP0002998_abnormal_bone_remodeling1.75911791
43MP0000858_altered_metastatic_potential1.65887496
44MP0006054_spinal_hemorrhage1.65678415
45MP0003806_abnormal_nucleotide_metabolis1.56715675
46MP0010155_abnormal_intestine_physiology1.55989485
47MP0005166_decreased_susceptibility_to1.51798214
48MP0002332_abnormal_exercise_endurance1.51227706
49MP0005164_abnormal_response_to1.41736064
50MP0002277_abnormal_respiratory_mucosa1.40552213
51MP0000716_abnormal_immune_system1.38058399
52MP0009333_abnormal_splenocyte_physiolog1.37376727
53MP0005310_abnormal_salivary_gland1.29776574
54MP0003828_pulmonary_edema1.26609148
55MP0005397_hematopoietic_system_phenotyp1.25170841
56MP0001545_abnormal_hematopoietic_system1.25170841
57MP0004782_abnormal_surfactant_physiolog1.20409169
58MP0003172_abnormal_lysosome_physiology1.15839482
59MP0005390_skeleton_phenotype1.13944785
60MP0002398_abnormal_bone_marrow1.12012648
61MP0005023_abnormal_wound_healing1.05707651
62MP0000569_abnormal_digit_pigmentation1.05303721
63MP0002429_abnormal_blood_cell1.04131089
64MP0009765_abnormal_xenobiotic_induced1.03272614
65MP0008260_abnormal_autophagy0.99890185
66MP0009763_increased_sensitivity_to0.97396321
67MP0005451_abnormal_body_composition0.95428609
68MP0005076_abnormal_cell_differentiation0.94663508
69MP0000689_abnormal_spleen_morphology0.89113403
70MP0000371_diluted_coat_color0.89073991
71MP0001542_abnormal_bone_strength0.86654347
72MP0005535_abnormal_body_temperature0.85802175
73MP0000604_amyloidosis0.85510389
74MP0010352_gastrointestinal_tract_polyps0.84566594
75MP0002933_joint_inflammation0.83487990
76MP0003690_abnormal_glial_cell0.83150129
77MP0008874_decreased_physiological_sensi0.81135114
78MP0005647_abnormal_sex_gland0.81123456
79MP0003453_abnormal_keratinocyte_physiol0.80328163
80MP0002837_dystrophic_cardiac_calcinosis0.79927438
81MP0002138_abnormal_hepatobiliary_system0.79667850
82MP0002722_abnormal_immune_system0.79027827
83MP0004808_abnormal_hematopoietic_stem0.77024129
84MP0003329_amyloid_beta_deposits0.76665265
85MP0000249_abnormal_blood_vessel0.75566573
86MP0005595_abnormal_vascular_smooth0.75493901
87MP0002254_reproductive_system_inflammat0.75176726
88MP0001501_abnormal_sleep_pattern0.75003795
89MP0001851_eye_inflammation0.73089238
90MP0010386_abnormal_urinary_bladder0.70623770
91MP0001727_abnormal_embryo_implantation0.70106311
92MP0001849_ear_inflammation0.69487075
93MP0003795_abnormal_bone_structure0.66602651
94MP0004883_abnormal_blood_vessel0.65983519
95MP0002877_abnormal_melanocyte_morpholog0.62241024
96MP0002136_abnormal_kidney_physiology0.60215685
97MP0003191_abnormal_cellular_cholesterol0.60189558
98MP0000750_abnormal_muscle_regeneration0.59819419
99MP0002693_abnormal_pancreas_physiology0.58039526
100MP0000465_gastrointestinal_hemorrhage0.58005175
101MP0000767_abnormal_smooth_muscle0.56673239
102MP0002295_abnormal_pulmonary_circulatio0.55811072
103MP0005319_abnormal_enzyme/_coenzyme0.55688230
104MP0003091_abnormal_cell_migration0.54428200
105MP0003279_aneurysm0.53311551
106MP0003045_fibrosis0.52711483
107MP0008004_abnormal_stomach_pH0.52598790
108MP0004858_abnormal_nervous_system0.52376559
109MP0003656_abnormal_erythrocyte_physiolo0.50728094
110MP0001663_abnormal_digestive_system0.49046491
111MP0005165_increased_susceptibility_to0.48417307
112MP0003183_abnormal_peptide_metabolism0.47943245
113MP0002090_abnormal_vision0.47898201
114MP0005171_absent_coat_pigmentation0.47632765
115MP0003221_abnormal_cardiomyocyte_apopto0.46288891
116MP0008873_increased_physiological_sensi0.46253272
117MP0005584_abnormal_enzyme/coenzyme_acti0.45982420
118MP0005257_abnormal_intraocular_pressure0.45903807
119MP0009697_abnormal_copulation0.45716644
120MP0000920_abnormal_myelination0.44910087
121MP0001881_abnormal_mammary_gland0.44049155
122MP0005408_hypopigmentation0.43119506

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)8.48894967
2Eczematoid dermatitis (HP:0000976)8.17325141
3Recurrent bacterial skin infections (HP:0005406)7.66532076
4Recurrent gram-negative bacterial infections (HP:0005420)7.48461249
5Mediastinal lymphadenopathy (HP:0100721)6.31195521
6Abnormality of macrophages (HP:0004311)5.56670623
7Stomatitis (HP:0010280)5.48033335
8Autoimmune thrombocytopenia (HP:0001973)4.85832315
9Elevated erythrocyte sedimentation rate (HP:0003565)4.83161726
10Gingivitis (HP:0000230)4.79315519
11Dysostosis multiplex (HP:0000943)4.48032981
12Recurrent skin infections (HP:0001581)4.45779175
13Retrobulbar optic neuritis (HP:0100654)4.44756073
14Optic neuritis (HP:0100653)4.44756073
15Increased IgM level (HP:0003496)4.41889045
16Obstructive lung disease (HP:0006536)4.40436625
17Chronic obstructive pulmonary disease (HP:0006510)4.40436625
18Loss of speech (HP:0002371)4.38351106
19Myositis (HP:0100614)4.28165726
20Orchitis (HP:0100796)4.27235584
21Mutism (HP:0002300)3.89646149
22Neurofibrillary tangles (HP:0002185)3.82109124
23Vasculitis (HP:0002633)3.77410528
24Axonal loss (HP:0003447)3.72803946
25Recurrent fungal infections (HP:0002841)3.62052848
26Prostate neoplasm (HP:0100787)3.52968054
27Nuclear cataract (HP:0100018)3.51185673
28Urticaria (HP:0001025)3.44301687
29Tetraparesis (HP:0002273)3.35674671
30Abnormality of polysaccharide metabolism (HP:0011012)3.24428392
31Abnormality of glycosaminoglycan metabolism (HP:0004371)3.24428392
32Abnormality of mucopolysaccharide metabolism (HP:0011020)3.24428392
33Gastrointestinal infarctions (HP:0005244)3.18092311
34Interstitial pulmonary disease (HP:0006530)3.14373246
35Pulmonary infiltrates (HP:0002113)3.13432722
36Systemic lupus erythematosus (HP:0002725)3.13128350
37Recurrent viral infections (HP:0004429)3.08996828
38Apathy (HP:0000741)3.06083564
39Cellulitis (HP:0100658)3.05815741
40Basal ganglia calcification (HP:0002135)3.04358874
41Urinary glycosaminoglycan excretion (HP:0003541)3.03328066
42Mucopolysacchariduria (HP:0008155)3.03328066
43Diminished motivation (HP:0000745)3.00671150
44Periodontitis (HP:0000704)3.00054883
45Amyloidosis (HP:0011034)2.98338002
46Thick nail (HP:0001805)2.93014362
47Recurrent pneumonia (HP:0006532)2.92842252
48Glomerulonephritis (HP:0000099)2.89651429
49Increased neuronal autofluorescent lipopigment (HP:0002074)2.89574723
50Metaphyseal irregularity (HP:0003025)2.87255259
51Vacuolated lymphocytes (HP:0001922)2.86853190
52Pustule (HP:0200039)2.83005299
53Meningitis (HP:0001287)2.80498294
54Abnormality of the vasculature of the conjunctiva (HP:0008054)2.78804328
55Poor head control (HP:0002421)2.74127218
56Cerebral inclusion bodies (HP:0100314)2.73883926
57Increased cerebral lipofuscin (HP:0011813)2.71861751
58Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.70364925
59Premature loss of primary teeth (HP:0006323)2.62780963
60Gingival bleeding (HP:0000225)2.61857389
61Leukocytosis (HP:0001974)2.59595158
62Hypergammaglobulinemia (HP:0010702)2.57074272
63Disinhibition (HP:0000734)2.56945765
64Abnormality of iron homeostasis (HP:0011031)2.56810147
65Nausea (HP:0002018)2.53125170
66Neuronal loss in central nervous system (HP:0002529)2.53120479
67Vertebral compression fractures (HP:0002953)2.52709769
68Keratoconjunctivitis sicca (HP:0001097)2.47960955
69Joint hemorrhage (HP:0005261)2.44493116
70Recurrent lower respiratory tract infections (HP:0002783)2.43636472
71Arterial thrombosis (HP:0004420)2.41833603
72Abnormality of the pericardium (HP:0001697)2.40483596
73Peritonitis (HP:0002586)2.40473232
74Osteomyelitis (HP:0002754)2.39350462
75Progressive neurologic deterioration (HP:0002344)2.38873181
76Inappropriate behavior (HP:0000719)2.37927518
77Bone pain (HP:0002653)2.37457401
78Abnormality of T cell number (HP:0011839)2.35021542
79Gastrointestinal stroma tumor (HP:0100723)2.32668048
80Polyneuropathy (HP:0001271)2.28768237
81Sepsis (HP:0100806)2.28668825
82Myocardial infarction (HP:0001658)2.28367013
83Keratoconjunctivitis (HP:0001096)2.27862803
84Hemoptysis (HP:0002105)2.27064501
85Recurrent cutaneous fungal infections (HP:0011370)2.26159425
86Chronic mucocutaneous candidiasis (HP:0002728)2.26159425
87Malnutrition (HP:0004395)2.25521833
88Joint swelling (HP:0001386)2.25245313
89Nephritis (HP:0000123)2.24298903
90Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.22613217
91Purpura (HP:0000979)2.18705377
92Abnormality of liposaccharide metabolism (HP:0010968)2.18380037
93Abnormality of glycosphingolipid metabolism (HP:0004343)2.18380037
94Abnormality of glycolipid metabolism (HP:0010969)2.18380037
95Arthralgia (HP:0002829)2.18067389
96Prolonged neonatal jaundice (HP:0006579)2.14862112
97Abnormality of transition element cation homeostasis (HP:0011030)2.09817407
98Parakeratosis (HP:0001036)2.09357959
99Gangrene (HP:0100758)2.08587328
100Complement deficiency (HP:0004431)2.07554195
101Anorexia (HP:0002039)2.07342342
102Petechiae (HP:0000967)2.04730339
103Asymmetric septal hypertrophy (HP:0001670)2.04496482
104Upper motor neuron abnormality (HP:0002127)2.03085882
105Hepatosplenomegaly (HP:0001433)2.02131717
106Esophageal neoplasm (HP:0100751)2.00019265
107Neoplasm of head and neck (HP:0012288)2.00019265
108Dementia (HP:0000726)1.99739358
109Abnormality of the prostate (HP:0008775)1.98467457
110Agnosia (HP:0010524)1.97362736
111Episodic fever (HP:0001954)1.96520166
112Chronic otitis media (HP:0000389)1.94220781
113Combined immunodeficiency (HP:0005387)1.93862667
114Conjunctival telangiectasia (HP:0000524)1.93856351
115T lymphocytopenia (HP:0005403)1.92186310
116Hematochezia (HP:0002573)1.91311075
117Abnormality of the pleura (HP:0002103)1.90745786
118Personality changes (HP:0000751)1.89707290
119Esophageal varix (HP:0002040)1.89593466
120Vertigo (HP:0002321)1.87980510
121Autoimmune hemolytic anemia (HP:0001890)1.85785299
122Thin bony cortex (HP:0002753)1.85450992
123Supranuclear gaze palsy (HP:0000605)1.84052111
124Hydroxyprolinuria (HP:0003080)1.82543412
125Abnormality of proline metabolism (HP:0010907)1.82543412
126Abnormality of cells of the lymphoid lineage (HP:0012140)1.81962356
127Increased serum ferritin (HP:0003281)1.80231321
128Porencephaly (HP:0002132)1.79491461
129Memory impairment (HP:0002354)1.79126258
130Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.78659892
131Skin ulcer (HP:0200042)1.75916458
132Lymphopenia (HP:0001888)1.71755726
133Restrictive lung disease (HP:0002091)1.70746977
134Epistaxis (HP:0000421)1.70154127
135Xerostomia (HP:0000217)1.69961202
136Pathologic fracture (HP:0002756)1.69852400
137Osteolytic defects of the hand bones (HP:0009699)1.68548412

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK47.39517922
2PBK5.50696609
3MAP3K144.86468590
4TBK13.75387653
5BLK3.50332489
6IRAK32.85061622
7IKBKB2.43413073
8JAK32.41848712
9IRAK42.40823538
10TAOK12.33795964
11TXK2.33436961
12IKBKE2.31090116
13MAP3K32.26022757
14TYK22.05126896
15MST1R1.91688510
16BMPR21.74910432
17MST41.70584620
18MAP3K131.69325198
19MAP2K31.66849149
20TGFBR21.62136177
21YES11.57354224
22CSK1.55296949
23CHUK1.48730744
24BMX1.48679120
25JAK11.47580243
26CDC42BPA1.45722238
27FGR1.33260639
28ACVR1B1.32076685
29ABL21.30155614
30MATK1.29750480
31TYRO31.24329994
32ERBB41.24317307
33ERN11.24250231
34PIM21.22885349
35LYN1.16684789
36MAP4K11.16058484
37SIK31.15685105
38NME21.13945378
39RPS6KA41.08369131
40STK41.01629851
41SYK1.00773231
42MARK30.99396851
43LATS20.95098152
44PIM10.91460613
45KIT0.91444685
46PDGFRA0.90610503
47ERBB30.90105089
48LCK0.88331314
49PRKCD0.87393646
50JAK20.86451749
51HCK0.85314359
52EIF2AK20.81260814
53ZAP700.80110418
54KSR20.79816948
55ARAF0.73965838
56DAPK20.71367909
57MAP3K50.71041809
58RIPK10.66911243
59BTK0.65270746
60TRPM70.63655309
61CLK10.63337838
62ABL10.63073181
63EGFR0.56751630
64TESK20.56175896
65BMPR1B0.55893145
66PRPF4B0.54296511
67TEC0.53512029
68MAPK40.53017033
69PDPK10.51577354
70MAP3K120.47796227
71STK30.47512969
72CSF1R0.47271814
73MAP2K60.46132788
74ADRBK20.45223351
75EPHB10.44994042
76PAK40.44740011
77MET0.44729521
78DAPK30.43298948
79NEK90.41843893
80PDK10.41500486
81STK100.41429540
82GRK70.40161224
83PRKCQ0.39754412
84MOS0.38297311
85RPS6KC10.38076469
86RPS6KL10.38076469
87FGFR30.37747520
88IRAK20.37129192
89BCR0.37029791
90PIK3CG0.36872569
91SIK10.36458584
92DYRK30.36255897
93CDK60.36125326
94CAMKK20.35682622
95FES0.35584553
96FYN0.35141625
97TESK10.34682713
98PDGFRB0.34108107
99ADRBK10.33832904
100PKN10.32465437
101STK240.30646582
102DDR20.30378397
103MUSK0.30035916
104IRAK10.29530413
105GSK3A0.29414967
106MAP3K90.28864930
107TAOK30.27396669
108MAP3K10.26750839
109PLK20.26299523
110NLK0.25545366
111INSR0.25508891
112MAP3K110.25478450
113IGF1R0.24432329
114PRKCE0.23732211
115PRKCZ0.20803893
116PDK20.20562574
117CDK40.18788520
118SIK20.18452059
119MAP3K80.18089592
120TAOK20.17826344
121RAF10.17441367
122CAMK1D0.17206398
123PRKG20.16912708
124TTN0.16395302
125RPS6KA10.16306193
126RPS6KA60.16053039
127MAPK70.14016397
128EPHA30.13905581
129RPS6KA20.13695246
130KSR10.13007331

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053324.71534616
2Leishmaniasis_Homo sapiens_hsa051403.55511903
3Type I diabetes mellitus_Homo sapiens_hsa049403.27499379
4* Legionellosis_Homo sapiens_hsa051343.14995780
5NOD-like receptor signaling pathway_Homo sapiens_hsa046212.99590697
6Allograft rejection_Homo sapiens_hsa053302.99475747
7Toll-like receptor signaling pathway_Homo sapiens_hsa046202.90318014
8Staphylococcus aureus infection_Homo sapiens_hsa051502.84421471
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.83388409
10Rheumatoid arthritis_Homo sapiens_hsa053232.79570947
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.73968674
12Malaria_Homo sapiens_hsa051442.48529109
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.40520459
14Asthma_Homo sapiens_hsa053102.39676498
15Pertussis_Homo sapiens_hsa051332.37299400
16African trypanosomiasis_Homo sapiens_hsa051432.22808237
17Tuberculosis_Homo sapiens_hsa051522.20190610
18Osteoclast differentiation_Homo sapiens_hsa043802.14334485
19* Salmonella infection_Homo sapiens_hsa051322.08406152
20RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.05654368
21* TNF signaling pathway_Homo sapiens_hsa046682.05165533
22Measles_Homo sapiens_hsa051621.81035440
23Phagosome_Homo sapiens_hsa041451.75414608
24Hematopoietic cell lineage_Homo sapiens_hsa046401.68384099
25Influenza A_Homo sapiens_hsa051641.59577593
26* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.49369345
27Intestinal immune network for IgA production_Homo sapiens_hsa046721.44615447
28Bladder cancer_Homo sapiens_hsa052191.39535689
29Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.36062822
30Herpes simplex infection_Homo sapiens_hsa051681.29632333
31Autoimmune thyroid disease_Homo sapiens_hsa053201.27229683
32* Chemokine signaling pathway_Homo sapiens_hsa040621.25615298
33Toxoplasmosis_Homo sapiens_hsa051451.24551120
34Lysosome_Homo sapiens_hsa041421.19922864
35Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.19460028
36Prion diseases_Homo sapiens_hsa050201.15072565
37AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.11634106
38Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.09072832
39B cell receptor signaling pathway_Homo sapiens_hsa046621.08314103
40Amoebiasis_Homo sapiens_hsa051461.06862150
41Apoptosis_Homo sapiens_hsa042101.05505240
42Shigellosis_Homo sapiens_hsa051311.03582485
43Jak-STAT signaling pathway_Homo sapiens_hsa046301.01071659
44Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.92514413
45Collecting duct acid secretion_Homo sapiens_hsa049660.90460988
46Hepatitis B_Homo sapiens_hsa051610.79912914
47Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.77338123
48Mineral absorption_Homo sapiens_hsa049780.75096443
49SNARE interactions in vesicular transport_Homo sapiens_hsa041300.74237503
50Viral myocarditis_Homo sapiens_hsa054160.71335673
51Sphingolipid metabolism_Homo sapiens_hsa006000.70349447
52Hepatitis C_Homo sapiens_hsa051600.70338701
53Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70291631
54Antigen processing and presentation_Homo sapiens_hsa046120.68900014
55Leukocyte transendothelial migration_Homo sapiens_hsa046700.62958522
56Primary immunodeficiency_Homo sapiens_hsa053400.60953639
57Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.60896364
58Sulfur metabolism_Homo sapiens_hsa009200.59425534
59Adipocytokine signaling pathway_Homo sapiens_hsa049200.57085410
60T cell receptor signaling pathway_Homo sapiens_hsa046600.56776129
61Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50977748
62Steroid biosynthesis_Homo sapiens_hsa001000.49886678
63Type II diabetes mellitus_Homo sapiens_hsa049300.49698135
64Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47905156
65Complement and coagulation cascades_Homo sapiens_hsa046100.47899576
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.45419271
67Proteasome_Homo sapiens_hsa030500.44042975
68Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43082020
69Acute myeloid leukemia_Homo sapiens_hsa052210.41975463
70Prolactin signaling pathway_Homo sapiens_hsa049170.40970982
71Epstein-Barr virus infection_Homo sapiens_hsa051690.40300025
72Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.38834344
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38830125
74Vibrio cholerae infection_Homo sapiens_hsa051100.38544781
75PPAR signaling pathway_Homo sapiens_hsa033200.35919722
76Galactose metabolism_Homo sapiens_hsa000520.35093412
77Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.33141196
78Platelet activation_Homo sapiens_hsa046110.32624574
79HIF-1 signaling pathway_Homo sapiens_hsa040660.31196304
80Other glycan degradation_Homo sapiens_hsa005110.30181871
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.29247356
82Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.27728670
83Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.27057384
84Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.26398517
85Dorso-ventral axis formation_Homo sapiens_hsa043200.25077483
86Fructose and mannose metabolism_Homo sapiens_hsa000510.21321832
87Renal cell carcinoma_Homo sapiens_hsa052110.20832430
88Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.20683550
89Chronic myeloid leukemia_Homo sapiens_hsa052200.18588184
90Systemic lupus erythematosus_Homo sapiens_hsa053220.17234326
91Insulin resistance_Homo sapiens_hsa049310.16792518
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.15089264
93GnRH signaling pathway_Homo sapiens_hsa049120.15004552
94Glycosaminoglycan degradation_Homo sapiens_hsa005310.13622752
95Proteoglycans in cancer_Homo sapiens_hsa052050.13614684
96Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.13179779
97FoxO signaling pathway_Homo sapiens_hsa040680.12040470
98Regulation of actin cytoskeleton_Homo sapiens_hsa048100.11584035
99Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.11570346
100Transcriptional misregulation in cancer_Homo sapiens_hsa052020.11389584
101Pancreatic cancer_Homo sapiens_hsa052120.11100132
102Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.09567722
103MAPK signaling pathway_Homo sapiens_hsa040100.08380985
104Synaptic vesicle cycle_Homo sapiens_hsa047210.07676653
105Small cell lung cancer_Homo sapiens_hsa052220.07360331
106Vitamin digestion and absorption_Homo sapiens_hsa049770.05011383
107Folate biosynthesis_Homo sapiens_hsa007900.04727531
108Viral carcinogenesis_Homo sapiens_hsa052030.04387552
109HTLV-I infection_Homo sapiens_hsa051660.03682344
110VEGF signaling pathway_Homo sapiens_hsa043700.02928517
111Notch signaling pathway_Homo sapiens_hsa043300.01867959
112Endocytosis_Homo sapiens_hsa041440.00121670

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