CXCL5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils, to promote angiogenesis and to remodel connective tissues. This protein is thought to play a role in cancer cell proliferation, migration, and invasion. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular response to cadmium ion (GO:0071276)9.43745869
2regulation of chemokine secretion (GO:0090196)7.10882274
3skin morphogenesis (GO:0043589)6.62713466
4cell adhesion mediated by integrin (GO:0033627)5.95854157
5positive regulation of chemokine secretion (GO:0090197)5.58319564
6hepatocyte apoptotic process (GO:0097284)5.50991238
7negative regulation of myeloid cell apoptotic process (GO:0033033)5.50721061
8regulation of mononuclear cell migration (GO:0071675)5.46567775
9eosinophil chemotaxis (GO:0048245)5.45279039
10response to peptidoglycan (GO:0032494)5.43446958
11regulation of macrophage chemotaxis (GO:0010758)5.04581678
12cellular extravasation (GO:0045123)4.96343531
13negative regulation of interleukin-12 production (GO:0032695)4.92411968
14respiratory burst (GO:0045730)4.92136439
15cellular response to ethanol (GO:0071361)4.90957472
16collagen fibril organization (GO:0030199)4.86563184
17eosinophil migration (GO:0072677)4.84695989
18interferon-gamma secretion (GO:0072643)4.77476955
19cellular response to thyroid hormone stimulus (GO:0097067)4.75868695
20hemidesmosome assembly (GO:0031581)4.60779896
21positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.60048165
22mesodermal cell differentiation (GO:0048333)4.56383703
23monocyte chemotaxis (GO:0002548)4.50397535
24lipopolysaccharide-mediated signaling pathway (GO:0031663)4.45012520
25regulation of lymphocyte chemotaxis (GO:1901623)4.33019827
26regulation of vitamin D biosynthetic process (GO:0060556)4.25337856
27macrophage differentiation (GO:0030225)4.24381204
28epithelial cell-cell adhesion (GO:0090136)4.22643033
29peptidyl-proline hydroxylation (GO:0019511)4.21480631
30protein localization to cell surface (GO:0034394)4.19348750
31glial cell proliferation (GO:0014009)4.18727500
32positive regulation of macrophage activation (GO:0043032)4.18444092
33wound healing, spreading of epidermal cells (GO:0035313)4.13172146
34regulation of transforming growth factor beta1 production (GO:0032908)4.11541903
35positive regulation of osteoblast proliferation (GO:0033690)4.09557138
36barbed-end actin filament capping (GO:0051016)4.09471052
37regulation of tight junction assembly (GO:2000810)4.09378358
38response to zinc ion (GO:0010043)4.07794152
39granulocyte chemotaxis (GO:0071621)4.02962424
40sequestering of extracellular ligand from receptor (GO:0035581)4.00527791
41positive regulation by symbiont of host defense response (GO:0052509)3.94800522
42modulation by symbiont of host defense response (GO:0052031)3.94800522
43modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.94800522
44modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.94800522
45positive regulation by organism of defense response of other organism involved in symbiotic interact3.94800522
46modulation by symbiont of host immune response (GO:0052553)3.94800522
47regulation of nephron tubule epithelial cell differentiation (GO:0072182)3.94378582
48response to cadmium ion (GO:0046686)3.89401395
49hydrogen peroxide biosynthetic process (GO:0050665)3.85936570
50granulocyte migration (GO:0097530)3.85704566
51positive regulation of actin filament depolymerization (GO:0030836)3.85692147
52regulation of podosome assembly (GO:0071801)3.78914332
53phagosome maturation (GO:0090382)3.77667515
54neutrophil chemotaxis (GO:0030593)3.77068029
55cytoskeletal anchoring at plasma membrane (GO:0007016)3.74684101
56superoxide anion generation (GO:0042554)3.73765677
57regulation of integrin-mediated signaling pathway (GO:2001044)3.72708087
58granulocyte activation (GO:0036230)3.69136494
59glycosphingolipid catabolic process (GO:0046479)3.67464957
60neutrophil migration (GO:1990266)3.67403071
61macrophage activation involved in immune response (GO:0002281)3.64941189
62response to magnesium ion (GO:0032026)3.64261671
63response to thyroid hormone (GO:0097066)3.62574672
64chondrocyte proliferation (GO:0035988)3.62497491
65positive regulation of gamma-delta T cell activation (GO:0046645)3.61942672
66apoptotic cell clearance (GO:0043277)3.57272482
67lymphocyte chemotaxis (GO:0048247)3.55887194
68wound healing, spreading of cells (GO:0044319)3.53496786
69COPI coating of Golgi vesicle (GO:0048205)3.52515534
70Golgi transport vesicle coating (GO:0048200)3.52515534
71keratinocyte proliferation (GO:0043616)3.51060077
72endodermal cell differentiation (GO:0035987)3.50756658
73neutrophil activation (GO:0042119)3.46734759
74regulation of vitamin metabolic process (GO:0030656)3.46649992
75positive regulation of establishment of protein localization to plasma membrane (GO:0090004)3.46444563
76glial cell migration (GO:0008347)3.44805484
77protein heterotrimerization (GO:0070208)3.43609276
78substrate-dependent cell migration (GO:0006929)3.41858078
79hypotonic response (GO:0006971)3.41079373
80reactive oxygen species biosynthetic process (GO:1903409)3.39152318
81intracellular pH reduction (GO:0051452)3.39094318
82protein hydroxylation (GO:0018126)3.38793729
83regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.37968877
84regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.35202473
85detection of molecule of bacterial origin (GO:0032490)3.33632752
86negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.33609995
87negative regulation of cell killing (GO:0031342)3.33609995
88regulation of epithelial cell differentiation involved in kidney development (GO:2000696)3.31017508
89positive regulation of monocyte chemotaxis (GO:0090026)3.29861149
90regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.29265400
91glycolipid catabolic process (GO:0019377)3.28668628
92positive regulation of protein localization to plasma membrane (GO:1903078)3.28505408
93regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.28413868
94branching involved in prostate gland morphogenesis (GO:0060442)3.28002245
95extracellular matrix disassembly (GO:0022617)3.27046076
96lung epithelium development (GO:0060428)3.25496045
97positive regulation of mast cell activation involved in immune response (GO:0033008)3.24051406
98positive regulation of mast cell degranulation (GO:0043306)3.24051406
99lung-associated mesenchyme development (GO:0060484)3.22642181
100regulation of vascular endothelial growth factor production (GO:0010574)3.22490148
101regulation of metalloenzyme activity (GO:0048552)3.21003838
102pH reduction (GO:0045851)3.20786681
103positive regulation of mast cell activation (GO:0033005)3.18495161
104regulation of interleukin-8 secretion (GO:2000482)3.18060204
105endothelial cell morphogenesis (GO:0001886)3.17396715
106negative regulation of chondrocyte differentiation (GO:0032331)3.17376001
107hepatocyte differentiation (GO:0070365)3.14536177
108protein localization to endosome (GO:0036010)3.14337597
109regulation of natural killer cell differentiation (GO:0032823)3.13508932
110maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.12297459
111fat-soluble vitamin biosynthetic process (GO:0042362)3.10338796
112positive regulation of heat generation (GO:0031652)3.08770564
113regulation of mast cell degranulation (GO:0043304)3.07519046
114macrophage activation (GO:0042116)3.07119472
115positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.05970472
116regulation of transmission of nerve impulse (GO:0051969)3.04138606
117immunoglobulin mediated immune response (GO:0016064)3.04042140
118regulation of osteoblast proliferation (GO:0033688)3.03184749
119regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.03108234
120regulation of lymphocyte migration (GO:2000401)3.02815902
121collagen metabolic process (GO:0032963)3.02329266
122wound healing (GO:0042060)3.02221632
123hippo signaling (GO:0035329)2.99189178
124positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.97034157
1254-hydroxyproline metabolic process (GO:0019471)2.96719672
126axon extension involved in axon guidance (GO:0048846)2.95772647
127neuron projection extension involved in neuron projection guidance (GO:1902284)2.95772647
128lens fiber cell development (GO:0070307)2.93077721
129protein retention in ER lumen (GO:0006621)2.92970797
130regulation of fever generation (GO:0031620)2.92936416
131myeloid cell activation involved in immune response (GO:0002275)2.92883969
132neutrophil activation involved in immune response (GO:0002283)2.92489800
133decidualization (GO:0046697)2.91563333
134cell-substrate junction assembly (GO:0007044)2.90864182
135regulation of transforming growth factor beta production (GO:0071634)2.89639888
136ceramide catabolic process (GO:0046514)2.89342184
137phagocytosis (GO:0006909)2.88248495
138NIK/NF-kappaB signaling (GO:0038061)2.86491631
139positive regulation of astrocyte differentiation (GO:0048711)2.86463866
140positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.86149168
141positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.85494738
142mesenchymal-epithelial cell signaling (GO:0060638)2.85452067
143negative regulation of interleukin-17 production (GO:0032700)2.84473031
144myeloid leukocyte migration (GO:0097529)2.84403231
145positive regulation of chemokine biosynthetic process (GO:0045080)2.84036190
146myeloid leukocyte activation (GO:0002274)2.84003940
147negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.83313402
148regulation of mast cell activation involved in immune response (GO:0033006)2.82199395
149positive regulation of leukocyte degranulation (GO:0043302)2.81888895
150positive regulation of endothelial cell apoptotic process (GO:2000353)2.81710032
151regulation of myeloid cell apoptotic process (GO:0033032)2.80659443
152mRNA transcription (GO:0009299)2.80505801
153membrane lipid catabolic process (GO:0046466)2.80447141
154positive regulation of epithelial to mesenchymal transition (GO:0010718)2.79620786
155regulation of dendritic cell antigen processing and presentation (GO:0002604)2.79574088
156adherens junction assembly (GO:0034333)2.79347361
157collagen catabolic process (GO:0030574)2.78320047
158monocyte differentiation (GO:0030224)2.77295542
159positive regulation of leukocyte chemotaxis (GO:0002690)2.77158080
160negative regulation of leukocyte chemotaxis (GO:0002689)2.77004603
161regulation of mast cell activation (GO:0033003)2.76940847
162regulation of transforming growth factor beta2 production (GO:0032909)2.76376611
163multicellular organismal macromolecule metabolic process (GO:0044259)2.76165408
164positive regulation of cellular amide metabolic process (GO:0034250)2.75077306
165oligosaccharide catabolic process (GO:0009313)2.75055485
166regulation of granulocyte chemotaxis (GO:0071622)2.73772772
167cellular response to interferon-alpha (GO:0035457)2.72412429
168positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.71499212
169leukocyte migration involved in inflammatory response (GO:0002523)2.71460440
170positive regulation of lymphocyte migration (GO:2000403)2.71180946
171cellular response to lipopolysaccharide (GO:0071222)2.70852579
172renal filtration (GO:0097205)2.70591592
173regulation of leukocyte degranulation (GO:0043300)2.69164713
174positive regulation of bone resorption (GO:0045780)2.69120540
175cartilage morphogenesis (GO:0060536)2.68277920
176negative regulation of interferon-gamma production (GO:0032689)2.66189089
177regulation of hippo signaling (GO:0035330)2.63720331
178positive regulation of vesicle fusion (GO:0031340)2.62681812
179detection of other organism (GO:0098543)2.62342612
180regulation of monocyte chemotaxis (GO:0090025)2.61738949
181cell migration involved in sprouting angiogenesis (GO:0002042)2.60420476
182positive regulation of epithelial cell migration (GO:0010634)2.59659327
183opsonization (GO:0008228)2.59428126
184cellular response to amino acid stimulus (GO:0071230)2.59390629
185positive regulation of pseudopodium assembly (GO:0031274)2.57663770
186multicellular organismal metabolic process (GO:0044236)2.56351866
187negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage (GO:1902230)2.56217112
188membrane budding (GO:0006900)2.55887349
189organ formation (GO:0048645)2.55440955
190protein targeting to plasma membrane (GO:0072661)2.54154941
191adhesion of symbiont to host cell (GO:0044650)2.53354572
192virion attachment to host cell (GO:0019062)2.53354572
193regulation of hydrogen peroxide metabolic process (GO:0010310)2.53222614
194branching involved in salivary gland morphogenesis (GO:0060445)2.51593824
195cellular response to zinc ion (GO:0071294)12.3870271

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.19444429
2BP1_19119308_ChIP-ChIP_Hs578T_Human6.94652643
3TRIM28_21343339_ChIP-Seq_HEK293_Human6.27299452
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse6.20146516
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.90149858
6RARG_19884340_ChIP-ChIP_MEFs_Mouse5.52023182
7NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human4.90575681
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.19669355
9IRF8_21731497_ChIP-ChIP_J774_Mouse4.11415098
10SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.88606193
11IRF8_27001747_Chip-Seq_BMDM_Mouse3.88436800
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.64751669
13STAT6_21828071_ChIP-Seq_BEAS2B_Human3.36485851
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.30988649
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.14027328
16CLOCK_20551151_ChIP-Seq_293T_Human3.05176633
17IRF8_22096565_ChIP-ChIP_GC-B_Human2.94757548
18ESR1_15608294_ChIP-ChIP_MCF-7_Human2.94527149
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.94097945
20SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.70372086
21SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.70372086
22CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.68882839
23SPI1_23127762_ChIP-Seq_K562_Human2.55712060
24RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.45917257
25CJUN_26792858_Chip-Seq_BT549_Human2.37733569
26BRD4_27068464_Chip-Seq_AML-cells_Mouse2.35024885
27CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.30734355
28SPI1_23547873_ChIP-Seq_NB4_Human2.30136247
29VDR_24763502_ChIP-Seq_THP-1_Human2.28428372
30SOX2_20726797_ChIP-Seq_SW620_Human2.25542922
31ESR1_21235772_ChIP-Seq_MCF-7_Human2.19677319
32HIF1A_21447827_ChIP-Seq_MCF-7_Human2.18369173
33* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.17856449
34SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.16355949
35FOXO3_23340844_ChIP-Seq_DLD1_Human2.13800299
36AR_21909140_ChIP-Seq_LNCAP_Human2.12621793
37RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.12529298
38SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.06698834
39FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.06160607
40STAT4_19710469_ChIP-ChIP_TH1__Mouse2.03310049
41* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.00795663
42* NRF2_20460467_ChIP-Seq_MEFs_Mouse2.00795663
43CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.99653493
44TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.99028878
45VDR_24787735_ChIP-Seq_THP-1_Human1.97117653
46CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.97036383
47PPAR_26484153_Chip-Seq_NCI-H1993_Human1.95975742
48RUNX1_22412390_ChIP-Seq_EML_Mouse1.89532194
49KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.86622607
50CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.83934567
51PU_27001747_Chip-Seq_BMDM_Mouse1.83910549
52JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.82747305
53STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.81358391
54ESR2_21235772_ChIP-Seq_MCF-7_Human1.80814821
55ATF3_27146783_Chip-Seq_COLON_Human1.80684802
56ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.78742415
57VDR_21846776_ChIP-Seq_THP-1_Human1.78197971
58EP300_21415370_ChIP-Seq_HL-1_Mouse1.76579017
59* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.76041716
60LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.75441770
61MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.75028324
62LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.70718842
63STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.70264846
64PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.66814361
65ELK1_22589737_ChIP-Seq_MCF10A_Human1.66666420
66BRD4_25478319_ChIP-Seq_HGPS_Human1.66492777
67CDX2_20551321_ChIP-Seq_CACO-2_Human1.64844691
68PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.63882177
69ESR1_20079471_ChIP-ChIP_T-47D_Human1.59254019
70WT1_19549856_ChIP-ChIP_CCG9911_Human1.58814448
71SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.57776007
72ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.57119187
73NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.54615396
74TP53_16413492_ChIP-PET_HCT116_Human1.52966581
75LXR_22292898_ChIP-Seq_THP-1_Human1.49410221
76SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.47958745
77PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.44606074
78ZNF263_19887448_ChIP-Seq_K562_Human1.44208006
79JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.43888116
80SCL_19346495_ChIP-Seq_HPC-7_Human1.40466884
81TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.39199385
82GATA1_19941826_ChIP-Seq_K562_Human1.39194479
83GATA1_19941827_ChIP-Seq_MEL_Mouse1.37059655
84ELK3_25401928_ChIP-Seq_HUVEC_Human1.36966926
85CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.36176110
86FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.36121857
87KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.35725121
88GATA2_21666600_ChIP-Seq_HMVEC_Human1.35309367
89CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.33851427
90PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.33128080
91KDM2B_26808549_Chip-Seq_SUP-B15_Human1.32932566
92VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.32087802
93SRY_22984422_ChIP-ChIP_TESTIS_Rat1.32067796
94P63_26484246_Chip-Seq_KERATINOCYTES_Human1.31197823
95SOX2_27498859_Chip-Seq_STOMACH_Mouse1.31065791
96* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.30890490
97ZNF217_24962896_ChIP-Seq_MCF-7_Human1.30258568
98NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.30203193
99HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.28821785
100TP53_18474530_ChIP-ChIP_U2OS_Human1.28003230
101CDX2_19796622_ChIP-Seq_MESCs_Mouse1.27345297
102* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.27302414
103* GATA4_25053715_ChIP-Seq_YYC3_Human1.26785848
104E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.26738854
105ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.23814402
106GATA1_22025678_ChIP-Seq_K562_Human1.21194203
107MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.20842354
108PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20772084
109SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.18406717
110SALL4_18804426_ChIP-ChIP_XEN_Mouse1.16803427
111* KLF5_25053715_ChIP-Seq_YYC3_Human1.16362782
112STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.15991270
113RUNX_20019798_ChIP-Seq_JUKART_Human1.15777758
114IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.15392325
115ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.15074044
116RACK7_27058665_Chip-Seq_MCF-7_Human1.14491934
117UBF1/2_26484160_Chip-Seq_HMECs_Human1.12239429
118TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.12175415
119* GATA6_25053715_ChIP-Seq_YYC3_Human1.12150436
120GATA3_24758297_ChIP-Seq_MCF-7_Human1.11695707
121IKZF1_21737484_ChIP-ChIP_HCT116_Human1.11387127
122P300_27058665_Chip-Seq_ZR-75-30cells_Human1.11044712
123UTX_26944678_Chip-Seq_JUKART_Human1.09688513
124GATA1_22383799_ChIP-Seq_G1ME_Mouse1.08803717
125EGR1_19032775_ChIP-ChIP_M12_Human1.07852343
126EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.07512956
127BCOR_27268052_Chip-Seq_Bcells_Human1.05835430
128UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.05809919
129SPI1_20517297_ChIP-Seq_HL60_Human1.05049616
130SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.05029777
131* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.04973626
132GATA2_19941826_ChIP-Seq_K562_Human1.04893169
133MAF_26560356_Chip-Seq_TH1_Human1.04519319
134HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.04275594
135FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04223952
136KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.04070615
137FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.03614756
138BCL6_27268052_Chip-Seq_Bcells_Human1.02580636
139TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02546262
140TCF7_22412390_ChIP-Seq_EML_Mouse1.01712731
141TFEB_21752829_ChIP-Seq_HELA_Human0.98371033
142* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.97083469
143STAT1_20625510_ChIP-Seq_HELA_Human0.96749328
144KDM2B_26808549_Chip-Seq_DND41_Human0.95965838
145EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.94847543
146SMC1_22415368_ChIP-Seq_MEFs_Mouse0.94778075
147SOX9_24532713_ChIP-Seq_HFSC_Mouse0.94482945
148RUNX1_27514584_Chip-Seq_MCF-7_Human0.94071110
149STAT3_1855785_ChIP-Seq_MESCs_Mouse0.93878069
150IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.89861490
151MYB_26560356_Chip-Seq_TH2_Human0.89802669
152PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.89541675
153SMAD_19615063_ChIP-ChIP_OVARY_Human0.88411694
154TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.88287566
155TP63_23658742_ChIP-Seq_EP156T_Human0.86960466
156WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.85365890
157TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.83430503
158CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.82988204
159BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.82279535
160KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.81359628
161RBPJ_22232070_ChIP-Seq_NCS_Mouse0.81286019
162ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.81243273
163POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.80970780
164* CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.78788333
165ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.77670340
166TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.77618742
167NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.77404396
168PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.75928978
169EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.75294659
170NCOR1_26117541_ChIP-Seq_K562_Human0.75099867
171ELF5_23300383_ChIP-Seq_T47D_Human0.74179950
172TP53_22127205_ChIP-Seq_IMR90_Human0.74027655
173ELF1_20517297_ChIP-Seq_JURKAT_Human0.73230503
174FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.72951970
175TCF4_18268006_ChIP-ChIP_LS174T_Human0.72497429
176MYB_21317192_ChIP-Seq_ERMYB_Mouse0.71498971
177FOXM1_26456572_ChIP-Seq_MCF-7_Human0.71225448

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.43655424
2MP0005275_abnormal_skin_tensile4.75172713
3MP0010234_abnormal_vibrissa_follicle4.70513362
4MP0003705_abnormal_hypodermis_morpholog4.49946317
5MP0009840_abnormal_foam_cell4.06866969
6MP0006054_spinal_hemorrhage4.00953539
7MP0005167_abnormal_blood-brain_barrier3.72444137
8MP0003279_aneurysm3.30184938
9MP0001958_emphysema3.24443410
10MP0002148_abnormal_hypersensitivity_rea3.23546105
11MP0002837_dystrophic_cardiac_calcinosis3.23114220
12MP0009384_cardiac_valve_regurgitation3.19424170
13MP0005503_abnormal_tendon_morphology3.15201060
14* MP0009785_altered_susceptibility_to3.13708008
15MP0010352_gastrointestinal_tract_polyps3.11334448
16MP0003300_gastrointestinal_ulcer2.99543363
17MP0005058_abnormal_lysosome_morphology2.96345190
18MP0000537_abnormal_urethra_morphology2.95853810
19* MP0002419_abnormal_innate_immunity2.81328635
20MP0003191_abnormal_cellular_cholesterol2.63171651
21MP0005023_abnormal_wound_healing2.58822464
22MP0009764_decreased_sensitivity_to2.55971574
23MP0005464_abnormal_platelet_physiology2.47497610
24MP0004510_myositis2.35034924
25MP0003828_pulmonary_edema2.32894067
26MP0005000_abnormal_immune_tolerance2.32117644
27MP0002060_abnormal_skin_morphology2.21984388
28MP0003806_abnormal_nucleotide_metabolis2.16318601
29MP0006082_CNS_inflammation2.15086890
30MP0005387_immune_system_phenotype2.14436164
31MP0001790_abnormal_immune_system2.14436164
32* MP0005025_abnormal_response_to2.13831339
33MP0005397_hematopoietic_system_phenotyp2.12182203
34MP0001545_abnormal_hematopoietic_system2.12182203
35MP0004272_abnormal_basement_membrane2.11454072
36MP0002295_abnormal_pulmonary_circulatio2.02860900
37MP0008004_abnormal_stomach_pH1.98462536
38MP0003172_abnormal_lysosome_physiology1.98344554
39MP0005257_abnormal_intraocular_pressure1.97761780
40MP0002139_abnormal_hepatobiliary_system1.87283904
41MP0002452_abnormal_antigen_presenting1.85667880
42MP0003448_altered_tumor_morphology1.83180442
43MP0003566_abnormal_cell_adhesion1.82754018
44MP0003091_abnormal_cell_migration1.76985910
45MP0008260_abnormal_autophagy1.70713605
46MP0001835_abnormal_antigen_presentation1.68820624
47MP0005623_abnormal_meninges_morphology1.68744133
48MP0005671_abnormal_response_to1.68699329
49MP0010678_abnormal_skin_adnexa1.57524751
50* MP0001845_abnormal_inflammatory_respons1.56338316
51* MP0002723_abnormal_immune_serum1.54627841
52MP0003195_calcinosis1.50663476
53MP0003453_abnormal_keratinocyte_physiol1.49572958
54MP0005310_abnormal_salivary_gland1.46459546
55MP0005084_abnormal_gallbladder_morpholo1.45699233
56MP0002896_abnormal_bone_mineralization1.43766808
57MP0005508_abnormal_skeleton_morphology1.43715925
58* MP0002420_abnormal_adaptive_immunity1.42453975
59* MP0001819_abnormal_immune_cell1.42262392
60MP0002933_joint_inflammation1.41813832
61MP0003656_abnormal_erythrocyte_physiolo1.40934942
62MP0000685_abnormal_immune_system1.40390000
63MP0001800_abnormal_humoral_immune1.39084688
64MP0001542_abnormal_bone_strength1.39071466
65* MP0008469_abnormal_protein_level1.35731192
66MP0004883_abnormal_blood_vessel1.35001615
67MP0001243_abnormal_dermal_layer1.33034487
68MP0010030_abnormal_orbit_morphology1.31902292
69MP0002405_respiratory_system_inflammati1.28690824
70MP0003690_abnormal_glial_cell1.27601788
71MP0002282_abnormal_trachea_morphology1.27521163
72MP0003329_amyloid_beta_deposits1.22082595
73MP0003252_abnormal_bile_duct1.21504196
74MP0000920_abnormal_myelination1.20038497
75MP0009765_abnormal_xenobiotic_induced1.19524546
76MP0003045_fibrosis1.16685293
77MP0009053_abnormal_anal_canal1.16208607
78MP0001849_ear_inflammation1.13180633
79MP0003115_abnormal_respiratory_system1.12472598
80MP0003724_increased_susceptibility_to1.11489211
81MP0002168_other_aberrant_phenotype1.07989088
82MP0002877_abnormal_melanocyte_morpholog1.07355785
83MP0001533_abnormal_skeleton_physiology1.06907301
84MP0000462_abnormal_digestive_system1.06139565
85MP0000343_altered_response_to1.05344837
86MP0001299_abnormal_eye_distance/1.05232089
87MP0005390_skeleton_phenotype1.04850654
88MP0008874_decreased_physiological_sensi1.03644500
89MP0004233_abnormal_muscle_weight1.02775848
90MP0009333_abnormal_splenocyte_physiolog1.01525431
91MP0000249_abnormal_blood_vessel1.01372579
92MP0005166_decreased_susceptibility_to1.01251767
93MP0002254_reproductive_system_inflammat1.00523097
94MP0003283_abnormal_digestive_organ0.99587006
95MP0009763_increased_sensitivity_to0.99582138
96MP0010771_integument_phenotype0.98308933
97MP0005164_abnormal_response_to0.97829471
98MP0005165_increased_susceptibility_to0.97822798
99MP0002928_abnormal_bile_duct0.97229316
100MP0000465_gastrointestinal_hemorrhage0.96085304
101MP0000627_abnormal_mammary_gland0.95505230
102MP0005595_abnormal_vascular_smooth0.94689900
103MP0004947_skin_inflammation0.93180851
104MP0000858_altered_metastatic_potential0.91660726
105MP0009379_abnormal_foot_pigmentation0.90624531
106MP0005220_abnormal_exocrine_pancreas0.89172933
107MP0000733_abnormal_muscle_development0.87522097
108MP0005451_abnormal_body_composition0.87025292
109MP0003075_altered_response_to0.84869851
110* MP0000716_abnormal_immune_system0.84480820
111MP0004133_heterotaxia0.84280459
112MP0005501_abnormal_skin_physiology0.83253228
113MP0005083_abnormal_biliary_tract0.82538527
114MP0001216_abnormal_epidermal_layer0.82485155
115MP0001853_heart_inflammation0.81577637
116MP0003303_peritoneal_inflammation0.81418127
117MP0003183_abnormal_peptide_metabolism0.81080185
118MP0003436_decreased_susceptibility_to0.80848050
119MP0010155_abnormal_intestine_physiology0.78572064
120MP0003937_abnormal_limbs/digits/tail_de0.78425955
121MP0000163_abnormal_cartilage_morphology0.76743807
122MP0003385_abnormal_body_wall0.74268126
123MP0002133_abnormal_respiratory_system0.73469357
124MP0005388_respiratory_system_phenotype0.73469357
125MP0002113_abnormal_skeleton_development0.72430870
126MP0000750_abnormal_muscle_regeneration0.71424581
127MP0003795_abnormal_bone_structure0.71250022
128MP0005365_abnormal_bile_salt0.71143069
129MP0005076_abnormal_cell_differentiation0.71056989
130MP0010307_abnormal_tumor_latency0.70501901
131MP0002115_abnormal_skeleton_extremities0.70201130
132MP0002998_abnormal_bone_remodeling0.67631320
133MP0002932_abnormal_joint_morphology0.66727516
134* MP0002429_abnormal_blood_cell0.66690479
135MP0005197_abnormal_uvea_morphology0.66301764
136MP0003950_abnormal_plasma_membrane0.65607761
137MP0005395_other_phenotype0.64489974
138MP0002234_abnormal_pharynx_morphology0.64429518
139MP0004019_abnormal_vitamin_homeostasis0.64397683
140MP0009250_abnormal_appendicular_skeleto0.63196532
141MP0001348_abnormal_lacrimal_gland0.62711751
142MP0000371_diluted_coat_color0.62682119
143MP0000767_abnormal_smooth_muscle0.62171060
144MP0004264_abnormal_extraembryonic_tissu0.62007290
145MP0000477_abnormal_intestine_morphology0.61744184
146MP0001881_abnormal_mammary_gland0.61461789
147MP0000604_amyloidosis0.60463826
148MP0004808_abnormal_hematopoietic_stem0.59778271
149MP0001177_atelectasis0.57512749
150MP0002277_abnormal_respiratory_mucosa0.56786629
151MP0009278_abnormal_bone_marrow0.56747054
152MP0005171_absent_coat_pigmentation0.56705248
153MP0002398_abnormal_bone_marrow0.56673532
154MP0002796_impaired_skin_barrier0.56670173
155MP0001663_abnormal_digestive_system0.56572766
156MP0001614_abnormal_blood_vessel0.55162731
157MP0004858_abnormal_nervous_system0.54811728
158MP0000689_abnormal_spleen_morphology0.54759493
159MP0003634_abnormal_glial_cell0.54313066
160MP0010368_abnormal_lymphatic_system0.54153693
161MP0003638_abnormal_response/metabolism_0.53644114
162MP0003942_abnormal_urinary_system0.53168676
163MP0000383_abnormal_hair_follicle0.53113431
164MP0005647_abnormal_sex_gland0.49516176
165MP0005319_abnormal_enzyme/_coenzyme0.49190512

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)7.84690230
2Eczematoid dermatitis (HP:0000976)7.80213321
3Premature rupture of membranes (HP:0001788)7.73065725
4Recurrent bacterial skin infections (HP:0005406)7.11127957
5Abnormality of macrophages (HP:0004311)6.78350951
6Recurrent gram-negative bacterial infections (HP:0005420)6.58460438
7Recurrent abscess formation (HP:0002722)6.43127222
8Atrophic scars (HP:0001075)6.04522736
9Abnormality of liposaccharide metabolism (HP:0010968)5.97989517
10Abnormality of glycosphingolipid metabolism (HP:0004343)5.97989517
11Abnormality of glycolipid metabolism (HP:0010969)5.97989517
12Peritonitis (HP:0002586)5.57876353
13Metaphyseal irregularity (HP:0003025)4.75207463
14Aortic dissection (HP:0002647)4.66970173
15Mediastinal lymphadenopathy (HP:0100721)4.58620553
16Shallow orbits (HP:0000586)4.36946431
17Fragile skin (HP:0001030)4.28951025
18Chronic obstructive pulmonary disease (HP:0006510)4.13836126
19Obstructive lung disease (HP:0006536)4.13836126
20Soft skin (HP:0000977)4.10407193
21Aortic aneurysm (HP:0004942)4.03864675
22Cervical subluxation (HP:0003308)4.02684289
23Dilatation of the ascending aorta (HP:0005111)4.00579426
24Arterial tortuosity (HP:0005116)3.93687058
25Vacuolated lymphocytes (HP:0001922)3.92176500
26Vascular tortuosity (HP:0004948)3.90739696
27Dysostosis multiplex (HP:0000943)3.90402457
28Increased cerebral lipofuscin (HP:0011813)3.84658828
29Micronodular cirrhosis (HP:0001413)3.80774244
30Recurrent skin infections (HP:0001581)3.70770360
31Abnormality of dentin (HP:0010299)3.62245191
32Neurofibrillary tangles (HP:0002185)3.60738834
33Petechiae (HP:0000967)3.57338181
34Spontaneous hematomas (HP:0007420)3.55686864
35Increased neuronal autofluorescent lipopigment (HP:0002074)3.52624606
36Short nail (HP:0001799)3.41263118
37Onycholysis (HP:0001806)3.40288488
38Ankle contracture (HP:0006466)3.40014606
39Mutism (HP:0002300)3.38137737
40Radial bowing (HP:0002986)3.36526291
41Hematochezia (HP:0002573)3.35833142
42Genu recurvatum (HP:0002816)3.34140711
43Myocardial infarction (HP:0001658)3.29665302
44Increased serum ferritin (HP:0003281)3.29317484
45Gingivitis (HP:0000230)3.26947742
46Bladder diverticulum (HP:0000015)3.23297925
47Abnormality of the vasculature of the conjunctiva (HP:0008054)3.18139028
48Premature loss of primary teeth (HP:0006323)3.15772125
49Systemic lupus erythematosus (HP:0002725)3.14700990
50Recurrent fungal infections (HP:0002841)3.11955691
51Wormian bones (HP:0002645)3.11594720
52Vertebral compression fractures (HP:0002953)3.11286960
53Mitral valve prolapse (HP:0001634)3.07296677
54Loss of speech (HP:0002371)3.05382487
55Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.03356026
56Conjunctival telangiectasia (HP:0000524)3.02219080
57Fragile nails (HP:0001808)3.00549716
58Subacute progressive viral hepatitis (HP:0006572)2.93882217
59Purpura (HP:0000979)2.93070100
60Osteomyelitis (HP:0002754)2.92565612
61Biconcave vertebral bodies (HP:0004586)2.88277776
62Malnutrition (HP:0004395)2.86580394
63Cerebral aneurysm (HP:0004944)2.85874757
64Abnormality of polysaccharide metabolism (HP:0011012)2.83320820
65Abnormality of glycosaminoglycan metabolism (HP:0004371)2.83320820
66Abnormality of mucopolysaccharide metabolism (HP:0011020)2.83320820
67Cellulitis (HP:0100658)2.82923029
68Amyloidosis (HP:0011034)2.82256259
69Bowed forearm bones (HP:0003956)2.77843585
70Bowing of the arm (HP:0006488)2.77843585
71Blue sclerae (HP:0000592)2.77291120
72Neonatal short-limb short stature (HP:0008921)2.76727758
73Bowel diverticulosis (HP:0005222)2.73518390
74Glomerulonephritis (HP:0000099)2.71404485
75Cerebral inclusion bodies (HP:0100314)2.68848303
76Fibular aplasia (HP:0002990)2.68803887
77Broad face (HP:0000283)2.67580896
78Infantile muscular hypotonia (HP:0008947)2.66689745
79Cardiovascular calcification (HP:0011915)2.62871568
80Xanthomatosis (HP:0000991)2.62821424
81Wrist flexion contracture (HP:0001239)2.62697288
82Broad metatarsal (HP:0001783)2.59610351
83Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.57770318
84Bone pain (HP:0002653)2.56688982
85Mucopolysacchariduria (HP:0008155)2.53967463
86Urinary glycosaminoglycan excretion (HP:0003541)2.53967463
87Abnormality of iron homeostasis (HP:0011031)2.53864774
88Short femoral neck (HP:0100864)2.51731567
89Ulnar bowing (HP:0003031)2.51060540
90Abnormality of the peritoneum (HP:0002585)2.50992226
91Urticaria (HP:0001025)2.49467690
92Abnormality of the acetabulum (HP:0003170)2.47817039
93Fused cervical vertebrae (HP:0002949)2.47763690
94Myositis (HP:0100614)2.47603338
95Right ventricular cardiomyopathy (HP:0011663)2.46281092
96Beaking of vertebral bodies (HP:0004568)2.44480073
97Retinal atrophy (HP:0001105)2.43329626
98Abnormal delivery (HP:0001787)2.42020789
99Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.41269972
100Disinhibition (HP:0000734)2.39222462
101Alopecia of scalp (HP:0002293)2.38512766
102Spinal cord compression (HP:0002176)2.38192772
103Epistaxis (HP:0000421)2.37892583
104Upper motor neuron abnormality (HP:0002127)2.37466102
105Recurrent pneumonia (HP:0006532)2.36969293
106Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.32495287
107Abnormality of the distal phalanges of the toes (HP:0010182)2.29521921
108Increased density of long bones (HP:0006392)2.29239411
109Milia (HP:0001056)2.28834928
110Abnormality of the calcaneus (HP:0008364)2.27408148
111Pathologic fracture (HP:0002756)2.26967207
112Autoimmune thrombocytopenia (HP:0001973)2.26933574
113Recurrent viral infections (HP:0004429)2.26562263
114Overgrowth (HP:0001548)2.25926067
115Tibial bowing (HP:0002982)2.24637765
116Ectopia lentis (HP:0001083)2.23194937
117Spondylolisthesis (HP:0003302)2.22213783
118Hypophosphatemia (HP:0002148)2.22113927
119Hyperextensible skin (HP:0000974)2.20655606
120Coxa vara (HP:0002812)2.20288802
121Flat occiput (HP:0005469)2.19680161
122Aneurysm (HP:0002617)2.19250102
123Axonal loss (HP:0003447)2.18083100
124Progressive visual loss (HP:0000529)2.16897513
125Elbow flexion contracture (HP:0002987)2.15921859
126Protuberant abdomen (HP:0001538)2.15575728
127Hemoptysis (HP:0002105)2.14196222
128Osteolytic defects of the hand bones (HP:0009699)2.14035840
129Osteolytic defects of the phalanges of the hand (HP:0009771)2.14035840
130Stomatitis (HP:0010280)2.13988346
131Pustule (HP:0200039)2.13847660
132Hepatosplenomegaly (HP:0001433)2.13789642
133Focal segmental glomerulosclerosis (HP:0000097)2.13124134
134Prolonged bleeding time (HP:0003010)2.12868634
135Neuronal loss in central nervous system (HP:0002529)2.12242371
136Spinal rigidity (HP:0003306)2.12084244
137Enlarged epiphyses (HP:0010580)2.11692018
138Abnormality of oral frenula (HP:0000190)2.09813504
139Broad distal phalanx of finger (HP:0009836)2.09497284
140Abnormality of transition element cation homeostasis (HP:0011030)2.09405298
141Deviation of the hallux (HP:0010051)2.09061894
142Tetraparesis (HP:0002273)2.09047276
143Buphthalmos (HP:0000557)2.07821703
144Nausea (HP:0002018)2.06738960
145Orchitis (HP:0100796)2.05488363
146Cerebral hemorrhage (HP:0001342)2.03492440
147Meningitis (HP:0001287)2.03130051
148Hallux valgus (HP:0001822)2.01479404
149Cone-rod dystrophy (HP:0000548)1.99589545
150Abnormality of the periventricular white matter (HP:0002518)1.99183275
151Increased connective tissue (HP:0009025)1.98728732
152Congenital glaucoma (HP:0001087)1.98501022
153Mesomelia (HP:0003027)1.96751530
154Symptomatic seizures (HP:0011145)1.95818149
155Glomerulosclerosis (HP:0000096)1.95631522
156Follicular hyperkeratosis (HP:0007502)1.95587896
157Osteoarthritis (HP:0002758)1.94462153
158Missing ribs (HP:0000921)1.94057432
159Abnormality of the distal phalanx of the thumb (HP:0009617)1.93732251
160Abnormality of the nasal mucosa (HP:0000433)1.93533734
161Bronchomalacia (HP:0002780)1.92478160
162Thin bony cortex (HP:0002753)1.92433372
163Tarsal synostosis (HP:0008368)1.92013143
164Femoral bowing (HP:0002980)1.91370787
165Diminished motivation (HP:0000745)1.88037562
166Ankyloglossia (HP:0010296)1.87835468
167Recurrent cutaneous fungal infections (HP:0011370)1.86978682
168Chronic mucocutaneous candidiasis (HP:0002728)1.86978682
169Delayed epiphyseal ossification (HP:0002663)1.86587949
170Abnormality of the proximal phalanges of the hand (HP:0009834)1.84689239
171Plantar hyperkeratosis (HP:0007556)1.83901816
172Mitral regurgitation (HP:0001653)1.83897242
173Distal lower limb muscle weakness (HP:0009053)1.83633692
174Prolonged neonatal jaundice (HP:0006579)1.83168006
175Dementia (HP:0000726)1.83114252
176Abnormality of the 2nd finger (HP:0004100)1.82395354
177Progressive neurologic deterioration (HP:0002344)1.80017227
178Spastic diplegia (HP:0001264)1.79863772
179Striae distensae (HP:0001065)1.79795672
180Asymmetric septal hypertrophy (HP:0001670)1.79784841
181Abnormality of the costochondral junction (HP:0000919)1.78958165
182Interstitial pulmonary disease (HP:0006530)1.78075130
183Elevated alkaline phosphatase (HP:0003155)1.76167022
184Abnormal platelet function (HP:0011869)1.76011511
185Impaired platelet aggregation (HP:0003540)1.76011511
186Vascular calcification (HP:0004934)1.75941096
187Optic neuritis (HP:0100653)1.75519559
188Retrobulbar optic neuritis (HP:0100654)1.75519559
189Polycythemia (HP:0001901)1.75479786
190Esophageal varix (HP:0002040)1.74560016
191Nonimmune hydrops fetalis (HP:0001790)1.74441922
192Coronal craniosynostosis (HP:0004440)1.73659222
193Abnormal vertebral ossification (HP:0100569)1.71777253
194Broad ribs (HP:0000885)1.71674946
19511 pairs of ribs (HP:0000878)1.69568341
196Flat acetabular roof (HP:0003180)1.68971073
197Joint laxity (HP:0001388)1.65892217

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA27.42033291
2RIPK44.65791974
3IRAK33.98975788
4BLK3.93070186
5TTN3.61125279
6FRK3.03515496
7CSK2.86624978
8MATK2.85451514
9DDR22.75634850
10FGR2.73440964
11LATS22.72969813
12TESK12.62760780
13PAK42.62539671
14FER2.55550313
15TRIB32.33930867
16NEK92.21257773
17MST42.17312591
18MST1R2.14540612
19CSF1R2.05117822
20PKN22.00913315
21LIMK11.98956024
22RPS6KB21.97588715
23ACVR1B1.89661363
24ERBB31.79924881
25LATS11.77624510
26PTK21.75972294
27PTK61.66625800
28TAOK21.63699720
29MAP3K111.63297564
30PDGFRA1.61045149
31CAMK1D1.58238561
32RIPK11.57688397
33ZAP701.52667671
34PAK31.52645988
35GRK71.52093557
36ERN11.50914912
37MAP3K121.47770049
38IRAK41.44722546
39LRRK21.44287514
40LYN1.43043625
41CDC42BPA1.40078357
42TRPM71.38491287
43TAOK11.34680154
44EPHB21.31290611
45NME21.28524547
46MAP2K11.28166611
47IKBKB1.25848800
48MAP2K31.25020997
49MET1.23974645
50PRPF4B1.23792601
51SCYL21.22501527
52RPS6KA41.17126407
53BMX1.15336006
54MAP3K31.13939876
55TESK21.13501743
56SYK1.12037651
57MAP2K21.10237679
58PBK1.09234933
59PIK3CA1.07353479
60MAP3K91.05079651
61CAMK1G1.02806994
62MAP3K21.00265895
63TAOK30.99650765
64IKBKE0.98991946
65ARAF0.96255004
66FES0.95476451
67PIM20.93919261
68MAP3K10.93402582
69JAK20.92483593
70STK100.92021726
71MAP4K10.91330233
72JAK30.89601012
73FGFR10.88996420
74MYLK0.88596734
75HCK0.87263352
76ADRBK20.87232140
77PAK20.84784860
78PDPK10.83832239
79FGFR20.83535375
80TYRO30.83393690
81EPHB10.79441602
82CDK60.79366418
83ERBB40.78598080
84MAP3K80.78062730
85MELK0.75928065
86STK30.73656401
87TGFBR20.72983737
88ILK0.72767412
89CAMK2B0.72684883
90TGFBR10.72532494
91MARK30.72445362
92RPS6KL10.71267096
93RPS6KC10.71267096
94EPHA30.70398082
95DAPK30.70258403
96BMPR20.65709649
97TXK0.64308378
98CAMK2D0.63929420
99MOS0.63465313
100KIT0.63428804
101PLK20.63006635
102SIK30.61285183
103LCK0.59384406
104BTK0.59210612
105PDK10.58835050
106RPS6KA60.58006113
107MAP3K130.57933126
108PDGFRB0.57105624
109TNIK0.56153678
110RPS6KA20.55654780
111NTRK10.54631574
112PLK30.53927656
113JAK10.52116658
114CAMK2G0.51708773
115CDK80.51121170
116ERBB20.50494345
117KSR20.49415285
118TBK10.48887636
119ROCK10.47878078
120CAMKK20.47381846
121PAK10.46849450
122ALK0.46617559
123AURKB0.45577486
124PRKCE0.45249475
125MAPK120.44668238
126KSR10.43600252
127PDK20.43434506
128FYN0.42534784
129SRC0.42448605
130MAP3K50.40566509
131DAPK20.40320427
132PASK0.40200740
133ABL20.39679724
134PRKCI0.39588851
135CHUK0.39256529
136ROCK20.37880745
137PTK2B0.37096257
138MAPK40.36428112
139BCKDK0.35866698
140DYRK1B0.35757966
141PRKCD0.34363142
142YES10.34285184
143CSNK1A1L0.33929716
144MAP2K60.33767084
145CAMK40.32640619
146INSR0.31387331
147BRAF0.31104275
148FLT30.31039447
149PRKCG0.30565673
150CSNK1G30.30455965
151RAF10.30358383
152TYK20.30271626
153BCR0.29951460
154IGF1R0.29303953
155PRKD10.28468026
156SIK10.27948796
157ABL10.27218540
158PRKG20.26035262
159CAMKK10.25585545
160KDR0.24405158
161EEF2K0.24049778
162EGFR0.23952886
163MAP3K140.22993187

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005244.63119754
2ECM-receptor interaction_Homo sapiens_hsa045123.82003166
3Pathogenic Escherichia coli infection_Homo sapiens_hsa051303.50173799
4Bacterial invasion of epithelial cells_Homo sapiens_hsa051003.04778816
5Lysosome_Homo sapiens_hsa041422.79568113
6Focal adhesion_Homo sapiens_hsa045102.72093641
7Adherens junction_Homo sapiens_hsa045202.70693880
8Small cell lung cancer_Homo sapiens_hsa052222.68149659
9Other glycan degradation_Homo sapiens_hsa005112.54363030
10Proteoglycans in cancer_Homo sapiens_hsa052052.47947516
11Staphylococcus aureus infection_Homo sapiens_hsa051502.42077839
12Bladder cancer_Homo sapiens_hsa052192.33287539
13Malaria_Homo sapiens_hsa051442.30592550
14Shigellosis_Homo sapiens_hsa051312.16446368
15Leukocyte transendothelial migration_Homo sapiens_hsa046702.08322404
16Amoebiasis_Homo sapiens_hsa051462.08233917
17Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.02851690
18Tight junction_Homo sapiens_hsa045301.95219489
19Salmonella infection_Homo sapiens_hsa051321.92603931
20* TNF signaling pathway_Homo sapiens_hsa046681.88637421
21Glycosaminoglycan degradation_Homo sapiens_hsa005311.83600502
22Collecting duct acid secretion_Homo sapiens_hsa049661.77062627
23AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.71916870
24Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.63960038
25* Chemokine signaling pathway_Homo sapiens_hsa040621.62876878
26Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.61339556
27Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.59557582
28Hippo signaling pathway_Homo sapiens_hsa043901.57259061
29Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.56838178
30Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.54258823
31p53 signaling pathway_Homo sapiens_hsa041151.52972044
32Chronic myeloid leukemia_Homo sapiens_hsa052201.46677622
33Toxoplasmosis_Homo sapiens_hsa051451.46611730
34TGF-beta signaling pathway_Homo sapiens_hsa043501.46531083
35Dilated cardiomyopathy_Homo sapiens_hsa054141.44274886
36Pancreatic cancer_Homo sapiens_hsa052121.43180241
37Viral carcinogenesis_Homo sapiens_hsa052031.40268192
38Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.36859961
39Systemic lupus erythematosus_Homo sapiens_hsa053221.36818111
40Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.35828011
41MicroRNAs in cancer_Homo sapiens_hsa052061.35189964
42Regulation of actin cytoskeleton_Homo sapiens_hsa048101.31551816
43HIF-1 signaling pathway_Homo sapiens_hsa040661.30796818
44Phagosome_Homo sapiens_hsa041451.28623889
45B cell receptor signaling pathway_Homo sapiens_hsa046621.24911998
46Legionellosis_Homo sapiens_hsa051341.21382289
47Thyroid cancer_Homo sapiens_hsa052161.21025474
48Galactose metabolism_Homo sapiens_hsa000521.19984206
49Leishmaniasis_Homo sapiens_hsa051401.19876875
50PI3K-Akt signaling pathway_Homo sapiens_hsa041511.17383410
51Melanoma_Homo sapiens_hsa052181.16437207
52Glutathione metabolism_Homo sapiens_hsa004801.15959499
53Hematopoietic cell lineage_Homo sapiens_hsa046401.14219548
54Graft-versus-host disease_Homo sapiens_hsa053321.13381554
55Central carbon metabolism in cancer_Homo sapiens_hsa052301.10348518
56Viral myocarditis_Homo sapiens_hsa054161.09846928
57Apoptosis_Homo sapiens_hsa042101.05758481
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.04795228
59* Rheumatoid arthritis_Homo sapiens_hsa053231.03739061
60N-Glycan biosynthesis_Homo sapiens_hsa005101.00558917
61Asthma_Homo sapiens_hsa053100.99195339
62Fructose and mannose metabolism_Homo sapiens_hsa000510.97180195
63Thyroid hormone synthesis_Homo sapiens_hsa049180.96683387
64Vibrio cholerae infection_Homo sapiens_hsa051100.90067591
65Pathways in cancer_Homo sapiens_hsa052000.89439356
66Colorectal cancer_Homo sapiens_hsa052100.86664648
67Chemical carcinogenesis_Homo sapiens_hsa052040.85639810
68Caffeine metabolism_Homo sapiens_hsa002320.85449005
69Platelet activation_Homo sapiens_hsa046110.85250300
70Influenza A_Homo sapiens_hsa051640.84753072
71Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.82929609
72* Pertussis_Homo sapiens_hsa051330.82148728
73HTLV-I infection_Homo sapiens_hsa051660.81895425
74Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.80734627
75* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.79661610
76Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.76217886
77Rap1 signaling pathway_Homo sapiens_hsa040150.75376372
78Endometrial cancer_Homo sapiens_hsa052130.75075212
79Antigen processing and presentation_Homo sapiens_hsa046120.74683807
80Glioma_Homo sapiens_hsa052140.74056884
81Hepatitis B_Homo sapiens_hsa051610.73390534
82Renin-angiotensin system_Homo sapiens_hsa046140.73193956
83PPAR signaling pathway_Homo sapiens_hsa033200.72994144
84RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.71493407
85Type I diabetes mellitus_Homo sapiens_hsa049400.71263121
86Hepatitis C_Homo sapiens_hsa051600.70742457
87Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.70322700
88Sphingolipid metabolism_Homo sapiens_hsa006000.67793585
89Renal cell carcinoma_Homo sapiens_hsa052110.67449688
90Allograft rejection_Homo sapiens_hsa053300.66346630
91Synaptic vesicle cycle_Homo sapiens_hsa047210.65786059
92Protein digestion and absorption_Homo sapiens_hsa049740.65474402
93Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.65293185
94Intestinal immune network for IgA production_Homo sapiens_hsa046720.64009938
95Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.61295121
96Prostate cancer_Homo sapiens_hsa052150.61287139
97Sulfur metabolism_Homo sapiens_hsa009200.58523439
98Measles_Homo sapiens_hsa051620.57494714
99Pentose phosphate pathway_Homo sapiens_hsa000300.56664429
100Axon guidance_Homo sapiens_hsa043600.56532723
101Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56171254
102Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55722080
103Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.55366490
104Toll-like receptor signaling pathway_Homo sapiens_hsa046200.53580975
105Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53009185
106Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.52013556
107Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51402062
108Mineral absorption_Homo sapiens_hsa049780.51103509
109VEGF signaling pathway_Homo sapiens_hsa043700.50328145
110Acute myeloid leukemia_Homo sapiens_hsa052210.50088828
111Autoimmune thyroid disease_Homo sapiens_hsa053200.49943215
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.49846555
113Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.49588615
114African trypanosomiasis_Homo sapiens_hsa051430.49056797
115Herpes simplex infection_Homo sapiens_hsa051680.48524331
116Endocytosis_Homo sapiens_hsa041440.48194865
117ErbB signaling pathway_Homo sapiens_hsa040120.46928941
118Alcoholism_Homo sapiens_hsa050340.46261388
119SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45748793
120Gap junction_Homo sapiens_hsa045400.45541042
121Tuberculosis_Homo sapiens_hsa051520.45298725
122NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43406603
123Transcriptional misregulation in cancer_Homo sapiens_hsa052020.41172171
124T cell receptor signaling pathway_Homo sapiens_hsa046600.41032331
125NF-kappa B signaling pathway_Homo sapiens_hsa040640.40344567
126Complement and coagulation cascades_Homo sapiens_hsa046100.39271573
127Basal cell carcinoma_Homo sapiens_hsa052170.39240183
128Wnt signaling pathway_Homo sapiens_hsa043100.38183554
129Osteoclast differentiation_Homo sapiens_hsa043800.37977869
130Prion diseases_Homo sapiens_hsa050200.36848695
131Primary bile acid biosynthesis_Homo sapiens_hsa001200.36848425
132Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.36822275
133Jak-STAT signaling pathway_Homo sapiens_hsa046300.36143654
134Estrogen signaling pathway_Homo sapiens_hsa049150.35753187
135Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35610564
136Phospholipase D signaling pathway_Homo sapiens_hsa040720.33455489
137Type II diabetes mellitus_Homo sapiens_hsa049300.31834825
138Neurotrophin signaling pathway_Homo sapiens_hsa047220.31832120
139Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.29094759
140Cell cycle_Homo sapiens_hsa041100.29052380
141Proteasome_Homo sapiens_hsa030500.26526623
142GnRH signaling pathway_Homo sapiens_hsa049120.26062199
143Adipocytokine signaling pathway_Homo sapiens_hsa049200.20814121
144Carbohydrate digestion and absorption_Homo sapiens_hsa049730.13825049
145MAPK signaling pathway_Homo sapiens_hsa040100.12754277
146Prolactin signaling pathway_Homo sapiens_hsa049170.11605427
147Epstein-Barr virus infection_Homo sapiens_hsa051690.09268397

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