CXCL6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of transforming growth factor beta1 production (GO:0032908)5.27579478
2cell adhesion mediated by integrin (GO:0033627)5.24328724
3pericardium development (GO:0060039)5.13512782
4peptidyl-proline hydroxylation (GO:0019511)5.12748350
5regulation of transmission of nerve impulse (GO:0051969)5.02717890
6positive regulation of astrocyte differentiation (GO:0048711)4.91506294
7skin morphogenesis (GO:0043589)4.83621930
8positive regulation of p38MAPK cascade (GO:1900745)4.64776952
9protein heterotrimerization (GO:0070208)4.61827566
10regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.46158177
11protein hydroxylation (GO:0018126)4.39725086
12positive regulation of chemokine secretion (GO:0090197)4.38691428
13positive regulation of macrophage activation (GO:0043032)4.36471616
14interleukin-6-mediated signaling pathway (GO:0070102)4.34128405
15regulation of plasminogen activation (GO:0010755)4.32900322
16positive regulation of neurological system process (GO:0031646)4.29249390
17regulation of chemokine secretion (GO:0090196)4.26290592
18positive regulation of type 2 immune response (GO:0002830)4.25754651
19regulation of apoptotic process involved in morphogenesis (GO:1902337)4.22898771
20regulation of vascular endothelial growth factor production (GO:0010574)4.21935013
21chondrocyte proliferation (GO:0035988)4.21418965
22regulation of immunoglobulin secretion (GO:0051023)4.12406001
23negative regulation of smooth muscle cell migration (GO:0014912)3.97040410
24endodermal cell differentiation (GO:0035987)3.94580670
25positive regulation of osteoblast proliferation (GO:0033690)3.93153705
26sequestering of extracellular ligand from receptor (GO:0035581)3.91349413
27UDP-N-acetylglucosamine metabolic process (GO:0006047)3.64105171
28regulation of transforming growth factor beta2 production (GO:0032909)3.63522323
29substrate-dependent cell migration (GO:0006929)3.62459197
30regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.61121380
31positive regulation of blood vessel endothelial cell migration (GO:0043536)3.54982389
32wound healing, spreading of epidermal cells (GO:0035313)3.52584878
33extracellular fibril organization (GO:0043206)3.51425281
34collagen fibril organization (GO:0030199)3.49241056
35regulation of transforming growth factor beta production (GO:0071634)3.37196389
36regulation of type B pancreatic cell apoptotic process (GO:2000674)3.36140061
37chronic inflammatory response (GO:0002544)3.34407572
38negative regulation of homotypic cell-cell adhesion (GO:0034111)3.34274060
39response to peptidoglycan (GO:0032494)3.32925136
40hypotonic response (GO:0006971)3.31967489
41collagen metabolic process (GO:0032963)3.27499984
42cell migration involved in sprouting angiogenesis (GO:0002042)3.22102048
43regulation of collagen metabolic process (GO:0010712)3.20854861
44fibrinolysis (GO:0042730)3.20587109
45regulation of mononuclear cell migration (GO:0071675)3.20350638
46collagen catabolic process (GO:0030574)3.19596802
47regulation of T-helper 2 cell differentiation (GO:0045628)3.18107515
48negative regulation of fibrinolysis (GO:0051918)3.17949684
49positive regulation of transforming growth factor beta production (GO:0071636)3.17779034
50regulation of extracellular matrix disassembly (GO:0010715)3.16930167
51cellular response to interleukin-6 (GO:0071354)3.15245112
52venous blood vessel morphogenesis (GO:0048845)3.13542494
53diterpenoid biosynthetic process (GO:0016102)3.13297512
54hyaluronan catabolic process (GO:0030214)3.13134759
55regulation of apoptotic cell clearance (GO:2000425)3.12372451
56negative regulation of leukocyte chemotaxis (GO:0002689)3.12353193
57fibril organization (GO:0097435)3.11466191
58glial cell migration (GO:0008347)3.10289318
59regulation of collagen biosynthetic process (GO:0032965)3.09324176
60positive regulation vascular endothelial growth factor production (GO:0010575)3.08745433
614-hydroxyproline metabolic process (GO:0019471)3.08353667
62regulation of chemokine biosynthetic process (GO:0045073)3.07641790
63COPI coating of Golgi vesicle (GO:0048205)3.07492552
64Golgi transport vesicle coating (GO:0048200)3.07492552
65negative regulation of chondrocyte differentiation (GO:0032331)3.06972954
66nucleotide-sugar biosynthetic process (GO:0009226)3.06871276
67multicellular organismal macromolecule metabolic process (GO:0044259)3.04128775
68mesodermal cell differentiation (GO:0048333)3.02504284
69pathway-restricted SMAD protein phosphorylation (GO:0060389)3.00218933
70multicellular organismal catabolic process (GO:0044243)2.99638290
71negative regulation of lipid storage (GO:0010888)2.98078026
72multicellular organismal metabolic process (GO:0044236)2.90911175
73extracellular matrix disassembly (GO:0022617)2.89288171
74lung lobe morphogenesis (GO:0060463)2.87849303
75positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)2.86240028
76protein retention in ER lumen (GO:0006621)2.84151260
77wound healing, spreading of cells (GO:0044319)2.79545076
78retina vasculature morphogenesis in camera-type eye (GO:0061299)2.77884287
79regulation of p38MAPK cascade (GO:1900744)2.77537448
80maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.77535285
81regulation of osteoblast proliferation (GO:0033688)2.75963915
82pyrimidine-containing compound transmembrane transport (GO:0072531)2.72378304
83regulation of interleukin-8 secretion (GO:2000482)2.70954060
84positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.69188423
85negative regulation of coagulation (GO:0050819)2.67923494
86COPII vesicle coating (GO:0048208)2.66790790
87regulation of macrophage chemotaxis (GO:0010758)2.65112787
88heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.64700286
89regulation of monocyte chemotaxis (GO:0090025)2.61533149
90calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.57862400
91blood vessel maturation (GO:0001955)2.56080686
92regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.54887277
93positive regulation of monocyte chemotaxis (GO:0090026)2.54237706
94cellular response to zinc ion (GO:0071294)2.53764521
95regulation of type 2 immune response (GO:0002828)2.51154774
96positive regulation of actin cytoskeleton reorganization (GO:2000251)2.50546038
97regulation of fibrinolysis (GO:0051917)2.49399642
98regulation of glucocorticoid metabolic process (GO:0031943)2.49379637
99cyclooxygenase pathway (GO:0019371)2.48842968
100defense response to Gram-negative bacterium (GO:0050829)2.48002195

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human6.47112782
2SMAD_19615063_ChIP-ChIP_OVARY_Human5.01750397
3PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.42651232
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.18334250
5* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.03020060
6SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.02456526
7CJUN_26792858_Chip-Seq_BT549_Human2.94463373
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.74845827
9TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.61945169
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.53288449
11PPAR_26484153_Chip-Seq_NCI-H1993_Human2.50303065
12BRD4_25478319_ChIP-Seq_HGPS_Human2.46499696
13CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.45157135
14GATA2_21666600_ChIP-Seq_HMVEC_Human2.42575067
15ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.32221985
16HIF1A_21447827_ChIP-Seq_MCF-7_Human2.27331495
17TP53_16413492_ChIP-PET_HCT116_Human2.19663875
18* SOX2_20726797_ChIP-Seq_SW620_Human2.17107946
19TP63_17297297_ChIP-ChIP_HaCaT_Human2.16629070
20CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.14941972
21STAT6_21828071_ChIP-Seq_BEAS2B_Human2.11134107
22NRF2_20460467_ChIP-Seq_MEFs_Mouse2.10882775
23NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.10882775
24WT1_19549856_ChIP-ChIP_CCG9911_Human2.01207875
25SALL4_18804426_ChIP-ChIP_XEN_Mouse1.98752200
26EP300_21415370_ChIP-Seq_HL-1_Mouse1.96951197
27* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.93564093
28* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.93564093
29TP53_18474530_ChIP-ChIP_U2OS_Human1.93561713
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.93365942
31ESR1_21235772_ChIP-Seq_MCF-7_Human1.87142149
32Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.85734909
33JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.79776439
34ZNF217_24962896_ChIP-Seq_MCF-7_Human1.79675171
35JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.77525583
36RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.72218824
37ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.68934134
38CDX2_19796622_ChIP-Seq_MESCs_Mouse1.65209825
39FOXO3_23340844_ChIP-Seq_DLD1_Human1.61487271
40ESR2_21235772_ChIP-Seq_MCF-7_Human1.55978544
41CLOCK_20551151_ChIP-Seq_293T_Human1.51897852
42* PIAS1_25552417_ChIP-Seq_VCAP_Human1.46785804
43KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.43838984
44CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.43632106
45ESR1_20079471_ChIP-ChIP_T-47D_Human1.43331091
46TP63_23658742_ChIP-Seq_EP156T_Human1.43307501
47FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.37180905
48ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.30352832
49FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.27826312
50SMC1_22415368_ChIP-Seq_MEFs_Mouse1.27010608
51GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.26253155
52EGR1_19374776_ChIP-ChIP_THP-1_Human1.25979831
53SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.18755941
54MYB_21317192_ChIP-Seq_ERMYB_Mouse1.16978611
55KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.16936836
56UBF1/2_26484160_Chip-Seq_HMECs_Human1.16849133
57NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.16712019
58NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.15167099
59HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.14852607
60BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.11993249
61NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.10936725
62TP53_22127205_ChIP-Seq_IMR90_Human1.06680703
63ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.05564781
64SA1_22415368_ChIP-Seq_MEFs_Mouse1.04278091
65AHR_22903824_ChIP-Seq_MCF-7_Human1.04243133
66P300_27058665_Chip-Seq_ZR-75-30cells_Human1.03607364
67ELK3_25401928_ChIP-Seq_HUVEC_Human1.02710212
68GATA4_25053715_ChIP-Seq_YYC3_Human1.00724009
69NFIB_24661679_ChIP-Seq_LUNG_Mouse0.98959068
70VDR_24787735_ChIP-Seq_THP-1_Human0.95900005
71P63_26484246_Chip-Seq_KERATINOCYTES_Human0.94248718
72STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.93277405
73TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92589456
74* CDX2_22108803_ChIP-Seq_LS180_Human0.90471114
75ATF3_27146783_Chip-Seq_COLON_Human0.90054960
76SOX2_27498859_Chip-Seq_STOMACH_Mouse0.89873622
77FOXM1_26456572_ChIP-Seq_MCF-7_Human0.88920965
78ARNT_22903824_ChIP-Seq_MCF-7_Human0.86523828
79PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86161912
80LXR_22158963_ChIP-Seq_LIVER_Mouse0.85423486
81CDX2_20551321_ChIP-Seq_CACO-2_Human0.85415055
82SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.83290245
83PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.82107361
84SMC3_22415368_ChIP-Seq_MEFs_Mouse0.81699208
85ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.79425587
86ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.79195887
87NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.78987759
88AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.78859845
89SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.78686946
90SMAD3_21741376_ChIP-Seq_HESCs_Human0.77926984
91RXR_22158963_ChIP-Seq_LIVER_Mouse0.77261406
92PCGF2_27294783_Chip-Seq_ESCs_Mouse0.76882608
93TBX20_22080862_ChIP-Seq_HEART_Mouse0.75824340
94TBX20_22328084_ChIP-Seq_HEART_Mouse0.75824340
95CTNNB1_20460455_ChIP-Seq_HCT116_Human0.73883626
96TCF4_18268006_ChIP-ChIP_LS174T_Human0.72519210
97NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.72254494
98PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human0.71328814
99STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.70859748
100SOX9_24532713_ChIP-Seq_HFSC_Mouse0.70074476

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen8.01765571
2MP0003300_gastrointestinal_ulcer4.20588066
3MP0008004_abnormal_stomach_pH4.02579276
4MP0004272_abnormal_basement_membrane3.84559040
5MP0005275_abnormal_skin_tensile3.40300400
6MP0003279_aneurysm3.24946153
7MP0003705_abnormal_hypodermis_morpholog3.18185286
8MP0005023_abnormal_wound_healing2.96965912
9MP0010386_abnormal_urinary_bladder2.75562593
10MP0005623_abnormal_meninges_morphology2.72787298
11MP0001958_emphysema2.72489890
12MP0005503_abnormal_tendon_morphology2.46670359
13MP0010352_gastrointestinal_tract_polyps2.29108598
14MP0005257_abnormal_intraocular_pressure2.20946015
15MP0003950_abnormal_plasma_membrane2.20813181
16MP0006082_CNS_inflammation2.08002606
17MP0009840_abnormal_foam_cell2.02251363
18MP0010368_abnormal_lymphatic_system1.87130646
19MP0003566_abnormal_cell_adhesion1.75371603
20MP0000343_altered_response_to1.74246736
21MP0002060_abnormal_skin_morphology1.73609512
22MP0009384_cardiac_valve_regurgitation1.71474086
23MP0002132_abnormal_respiratory_system1.69549080
24MP0006054_spinal_hemorrhage1.63737283
25MP0005164_abnormal_response_to1.60375191
26MP0003724_increased_susceptibility_to1.58513757
27MP0003091_abnormal_cell_migration1.58477603
28MP0004233_abnormal_muscle_weight1.54018896
29MP0005166_decreased_susceptibility_to1.40001334
30MP0005508_abnormal_skeleton_morphology1.39168854
31MP0003436_decreased_susceptibility_to1.37798299
32MP0002295_abnormal_pulmonary_circulatio1.37218388
33MP0009785_altered_susceptibility_to1.33516088
34MP0002168_other_aberrant_phenotype1.30392345
35MP0002933_joint_inflammation1.28314716
36MP0000462_abnormal_digestive_system1.27596020
37MP0009764_decreased_sensitivity_to1.23865399
38MP0002138_abnormal_hepatobiliary_system1.23862498
39MP0001533_abnormal_skeleton_physiology1.21493534
40MP0000767_abnormal_smooth_muscle1.21049780
41MP0001542_abnormal_bone_strength1.20504387
42MP0003448_altered_tumor_morphology1.19660518
43MP0002998_abnormal_bone_remodeling1.19427081
44MP0002896_abnormal_bone_mineralization1.18077576
45MP0009250_abnormal_appendicular_skeleto1.17854208
46MP0005390_skeleton_phenotype1.17178795
47MP0003191_abnormal_cellular_cholesterol1.15038847
48MP0002006_tumorigenesis1.15033426
49MP0002148_abnormal_hypersensitivity_rea1.13920830
50MP0000249_abnormal_blood_vessel1.13296307
51MP0001879_abnormal_lymphatic_vessel1.11902222
52MP0002163_abnormal_gland_morphology1.09141671
53MP0000013_abnormal_adipose_tissue1.08501538
54MP0005595_abnormal_vascular_smooth1.06844511
55MP0002332_abnormal_exercise_endurance1.04170057
56MP0003941_abnormal_skin_development1.03568621
57MP0000858_altered_metastatic_potential1.02572212
58MP0002089_abnormal_postnatal_growth/wei0.97863653
59MP0005171_absent_coat_pigmentation0.97776809
60MP0003828_pulmonary_edema0.96538735
61MP0000613_abnormal_salivary_gland0.90847114
62MP0005197_abnormal_uvea_morphology0.90260173
63MP0004134_abnormal_chest_morphology0.87767862
64MP0009780_abnormal_chondrocyte_physiolo0.86654675
65MP0005165_increased_susceptibility_to0.86634322
66MP0005084_abnormal_gallbladder_morpholo0.85099378
67MP0004858_abnormal_nervous_system0.83958074
68MP0002277_abnormal_respiratory_mucosa0.83505242
69MP0001614_abnormal_blood_vessel0.82026446
70MP0005388_respiratory_system_phenotype0.80274640
71MP0002133_abnormal_respiratory_system0.80274640
72MP0000163_abnormal_cartilage_morphology0.78507155
73MP0001243_abnormal_dermal_layer0.77810561
74MP0004510_myositis0.75609237
75MP0003045_fibrosis0.75565269
76MP0002282_abnormal_trachea_morphology0.74903114
77MP0000750_abnormal_muscle_regeneration0.72632603
78MP0002405_respiratory_system_inflammati0.72242939
79MP0002877_abnormal_melanocyte_morpholog0.70877630
80MP0004947_skin_inflammation0.70807229
81MP0001853_heart_inflammation0.70589005
82MP0004084_abnormal_cardiac_muscle0.69793932
83MP0002113_abnormal_skeleton_development0.68853413
84MP0003453_abnormal_keratinocyte_physiol0.68842689
85MP0003075_altered_response_to0.68335546
86MP0003795_abnormal_bone_structure0.67634174
87MP0002419_abnormal_innate_immunity0.67597164
88MP0009765_abnormal_xenobiotic_induced0.63652670
89MP0002128_abnormal_blood_circulation0.61940858
90MP0001915_intracranial_hemorrhage0.61742386
91MP0002925_abnormal_cardiovascular_devel0.61445025
92MP0010155_abnormal_intestine_physiology0.61163703
93MP0000733_abnormal_muscle_development0.60123586
94MP0001299_abnormal_eye_distance/0.59221303
95MP0001845_abnormal_inflammatory_respons0.58633641
96MP0003252_abnormal_bile_duct0.58355827
97MP0010771_integument_phenotype0.58128356
98MP0001501_abnormal_sleep_pattern0.57216043
99MP0005395_other_phenotype0.56577168
100MP0003690_abnormal_glial_cell0.56471824

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)8.38844408
2Premature rupture of membranes (HP:0001788)7.94975745
3Aortic dissection (HP:0002647)6.57651959
4Arterial tortuosity (HP:0005116)5.65064315
5Vascular tortuosity (HP:0004948)5.38154041
6Spondylolisthesis (HP:0003302)4.91425563
7Aortic aneurysm (HP:0004942)4.81215502
8Soft skin (HP:0000977)4.59527665
9Follicular hyperkeratosis (HP:0007502)4.29273301
10Abnormality of dentin (HP:0010299)4.25571383
11Abnormality of proline metabolism (HP:0010907)4.19037874
12Hydroxyprolinuria (HP:0003080)4.19037874
13Atrophic scars (HP:0001075)3.96888347
14Broad metatarsal (HP:0001783)3.95585592
15Wormian bones (HP:0002645)3.74720305
16Vertebral compression fractures (HP:0002953)3.59841803
17Cervical subluxation (HP:0003308)3.52170939
18Neonatal short-limb short stature (HP:0008921)3.51325725
19Ankle contracture (HP:0006466)3.47746156
20Mitral stenosis (HP:0001718)3.46391955
21Fragile skin (HP:0001030)3.43483562
22Blue sclerae (HP:0000592)3.40740925
23Overgrowth (HP:0001548)3.40650920
24Genu recurvatum (HP:0002816)3.28710174
25Mitral valve prolapse (HP:0001634)3.28418308
26Bladder diverticulum (HP:0000015)3.27279236
27Dilatation of the ascending aorta (HP:0005111)3.19716920
28Peritonitis (HP:0002586)3.18495569
29Cardiovascular calcification (HP:0011915)3.12906297
30Ileus (HP:0002595)3.05239720
31Hyperextensible skin (HP:0000974)3.01427424
32Rectal prolapse (HP:0002035)2.79732965
33Biconcave vertebral bodies (HP:0004586)2.79070589
34Male infertility (HP:0003251)2.79059917
35Joint laxity (HP:0001388)2.74620254
36Aortic regurgitation (HP:0001659)2.74534128
37Type 1 muscle fiber predominance (HP:0003803)2.73794987
38Femoral bowing (HP:0002980)2.73373954
39Abnormality of glutamine family amino acid metabolism (HP:0010902)2.70440709
40Shallow orbits (HP:0000586)2.69246975
41Ankyloglossia (HP:0010296)2.66907368
42Spinal rigidity (HP:0003306)2.64194181
43Thin bony cortex (HP:0002753)2.64082461
44Abnormality of the acetabulum (HP:0003170)2.59618080
45Cerebral aneurysm (HP:0004944)2.56586096
46Elbow flexion contracture (HP:0002987)2.56570740
47Striae distensae (HP:0001065)2.52338020
48Tetraparesis (HP:0002273)2.49101698
49Round ear (HP:0100830)2.48288112
50Knee flexion contracture (HP:0006380)2.42763808
51Pterygium (HP:0001059)2.38966033
52Slender build (HP:0001533)2.36399657
53Glomerulonephritis (HP:0000099)2.29203248
54Disproportionate tall stature (HP:0001519)2.28327841
55Aneurysm (HP:0002617)2.25248849
56Inguinal hernia (HP:0000023)2.20513927
57Ectopia lentis (HP:0001083)2.20395265
58Joint stiffness (HP:0001387)2.18657125
59Pectus carinatum (HP:0000768)2.17121670
60Hypoplasia of the iris (HP:0007676)2.16775337
61Abnormality of the right ventricle (HP:0001707)2.15495422
62Abnormal delivery (HP:0001787)2.15264337
63Abnormality of oral frenula (HP:0000190)2.13062274
64Congenital glaucoma (HP:0001087)2.11399846
65Wrist flexion contracture (HP:0001239)2.10049691
66Coxa vara (HP:0002812)2.08076765
67Mitral regurgitation (HP:0001653)2.07811336
68Aortic valve stenosis (HP:0001650)2.07083702
69Thoracolumbar scoliosis (HP:0002944)2.06329498
70Mildly elevated creatine phosphokinase (HP:0008180)2.03988306
71Recurrent corneal erosions (HP:0000495)2.03452768
72Osteolytic defects of the hand bones (HP:0009699)2.02111156
73Osteolytic defects of the phalanges of the hand (HP:0009771)2.02111156
74Pulmonic stenosis (HP:0001642)2.01562004
75Hand muscle atrophy (HP:0009130)2.00686547
76Broad ribs (HP:0000885)1.99079876
77Corneal dystrophy (HP:0001131)1.99077449
78Ovoid vertebral bodies (HP:0003300)1.97675306
79Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.97184188
80Nephritis (HP:0000123)1.94744745
81Urinary glycosaminoglycan excretion (HP:0003541)1.89480611
82Mucopolysacchariduria (HP:0008155)1.89480611
83Upper limb amyotrophy (HP:0009129)1.89378114
84Distal upper limb amyotrophy (HP:0007149)1.89378114
85Short nail (HP:0001799)1.88879678
86Abnormality of the nasal mucosa (HP:0000433)1.87375916
87Exocrine pancreatic insufficiency (HP:0001738)1.86885443
88Menorrhagia (HP:0000132)1.86466125
89Hypoventilation (HP:0002791)1.86125497
90Abnormality of the phalanges of the 2nd finger (HP:0009541)1.84415695
91Increased corneal curvature (HP:0100692)1.82679863
92Keratoconus (HP:0000563)1.82679863
93Abnormality of the anterior chamber (HP:0000593)1.80969431
94Severe short stature (HP:0003510)1.80817344
95Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.80002370
96Osteopenia (HP:0000938)1.79235204
97Alopecia of scalp (HP:0002293)1.77317457
98Abnormality of the middle phalanges of the toes (HP:0010183)1.77237524
99Abnormality of glycosaminoglycan metabolism (HP:0004371)1.73790014
100Abnormality of mucopolysaccharide metabolism (HP:0011020)1.73790014

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK28.67359697
2TGFBR23.55594782
3LATS23.46447879
4STK38L3.08852446
5STK242.89777864
6PRKG22.65897516
7EPHB22.59327826
8MAP3K122.51806300
9ERN12.35745790
10MYLK2.19147659
11PTK22.06034215
12NEK91.99791738
13NTRK11.93555329
14PDGFRA1.93412632
15DDR21.82897203
16PAK41.59224539
17ARAF1.52431075
18MST41.51108498
19EPHA21.49872580
20STK381.40045753
21MET1.36963000
22TEC1.33690252
23BCR1.31845846
24IRAK31.31739189
25STK31.31157154
26MAP3K131.24410665
27MST1R1.24142445
28BMPR21.21763728
29FLT31.20456513
30CDK81.20406891
31LIMK11.17842584
32ROCK11.15538569
33ERBB41.12871602
34ERBB31.11480594
35TGFBR11.04370483
36LATS11.02188320
37MOS1.01032867
38CDC42BPA0.98194895
39PAK20.96863734
40TESK10.96838860
41TIE10.96602928
42MAP3K30.89348226
43JAK10.88476436
44WNK40.86760575
45MAP3K90.86730111
46TRPM70.83695106
47ZAP700.82457912
48MELK0.81130200
49PDGFRB0.80272815
50STK390.79779024
51TNIK0.77687921
52PIK3CA0.76022960
53MAPK70.72851183
54TYK20.69376383
55WNK10.65923623
56PLK20.62648944
57ABL20.61664952
58PDK20.61614534
59TTN0.60747612
60PRKCE0.60577249
61RIPK10.59380249
62JAK30.55660893
63PRKD20.54626888
64AKT30.52765590
65ROCK20.52133771
66CLK10.52021578
67ILK0.51651018
68MAPK150.51540644
69EIF2AK30.51515088
70TBK10.49359404
71EPHB10.45843289
72KSR20.43319921
73MAP3K20.42626752
74DAPK30.41362783
75SIK10.40602960
76MAP3K60.40433149
77MAPK110.39483265
78MAP3K70.38655442
79MAPKAPK30.37820389
80TAOK20.37766004
81GRK10.36751686
82MAP3K140.35244978
83PIM20.35192904
84BRSK20.33959747
85PRKCD0.32110859
86HIPK20.29833336
87CASK0.29407827
88CDK90.28715281
89PTK2B0.28203174
90INSRR0.25338741
91KSR10.25036554
92MAP2K30.24988351
93MTOR0.24835401
94SRC0.23683228
95PRKD10.22987475
96PIK3CG0.22586992
97ABL10.22487015
98MAP3K80.20853033
99MAP2K10.20062388
100PDPK10.19771941

Predicted pathways (KEGG)

RankGene SetZ-score
1Malaria_Homo sapiens_hsa051443.33311671
2Amoebiasis_Homo sapiens_hsa051462.94780821
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.93564272
4ECM-receptor interaction_Homo sapiens_hsa045122.82765219
5NOD-like receptor signaling pathway_Homo sapiens_hsa046212.63703226
6TNF signaling pathway_Homo sapiens_hsa046682.62049904
7AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.55813383
8Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.54710523
9Legionellosis_Homo sapiens_hsa051342.36414187
10* Rheumatoid arthritis_Homo sapiens_hsa053232.35094722
11Sulfur metabolism_Homo sapiens_hsa009202.16852470
12Prion diseases_Homo sapiens_hsa050202.16169883
13Salmonella infection_Homo sapiens_hsa051322.11753873
14African trypanosomiasis_Homo sapiens_hsa051432.00374321
15* Pertussis_Homo sapiens_hsa051331.88136572
16Complement and coagulation cascades_Homo sapiens_hsa046101.76398929
17* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.72631297
18Focal adhesion_Homo sapiens_hsa045101.67826717
19Bladder cancer_Homo sapiens_hsa052191.60790828
20Vibrio cholerae infection_Homo sapiens_hsa051101.58043788
21Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.55487779
22Hematopoietic cell lineage_Homo sapiens_hsa046401.52860539
23Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.50170159
24Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.41559191
25Protein digestion and absorption_Homo sapiens_hsa049741.39434038
26Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.37561370
27Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.30638404
28Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.28417082
29Glycosaminoglycan degradation_Homo sapiens_hsa005311.27562267
30Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.26415682
31Proteoglycans in cancer_Homo sapiens_hsa052051.24333682
32Small cell lung cancer_Homo sapiens_hsa052221.21109852
33TGF-beta signaling pathway_Homo sapiens_hsa043501.14218824
34Shigellosis_Homo sapiens_hsa051311.11003154
35Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.09200037
36Leukocyte transendothelial migration_Homo sapiens_hsa046701.08770972
37Influenza A_Homo sapiens_hsa051641.03099979
38PI3K-Akt signaling pathway_Homo sapiens_hsa041510.98484589
39Mineral absorption_Homo sapiens_hsa049780.96902322
40Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.92886484
41Regulation of actin cytoskeleton_Homo sapiens_hsa048100.92861017
42Adherens junction_Homo sapiens_hsa045200.92218219
43Hepatitis C_Homo sapiens_hsa051600.90417830
44NF-kappa B signaling pathway_Homo sapiens_hsa040640.90092698
45Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.86670244
46Sphingolipid metabolism_Homo sapiens_hsa006000.85560550
47Galactose metabolism_Homo sapiens_hsa000520.84283336
48Renal cell carcinoma_Homo sapiens_hsa052110.82138052
49Pathways in cancer_Homo sapiens_hsa052000.81291914
50Toll-like receptor signaling pathway_Homo sapiens_hsa046200.81244244
51Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.78469506
52Tight junction_Homo sapiens_hsa045300.78364312
53N-Glycan biosynthesis_Homo sapiens_hsa005100.76546708
54Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.75977140
55Leishmaniasis_Homo sapiens_hsa051400.75295696
56Glutathione metabolism_Homo sapiens_hsa004800.75294514
57Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.75098519
58Chronic myeloid leukemia_Homo sapiens_hsa052200.74818201
59Phagosome_Homo sapiens_hsa041450.74564218
60Other glycan degradation_Homo sapiens_hsa005110.73969787
61Jak-STAT signaling pathway_Homo sapiens_hsa046300.73501603
62Circadian rhythm_Homo sapiens_hsa047100.72776617
63p53 signaling pathway_Homo sapiens_hsa041150.69517637
64* Chemokine signaling pathway_Homo sapiens_hsa040620.68208888
65HIF-1 signaling pathway_Homo sapiens_hsa040660.66217138
66Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.64987111
67Graft-versus-host disease_Homo sapiens_hsa053320.64832221
68Pancreatic cancer_Homo sapiens_hsa052120.64773974
69Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62396925
70Dilated cardiomyopathy_Homo sapiens_hsa054140.62193081
71Protein export_Homo sapiens_hsa030600.58259413
72Measles_Homo sapiens_hsa051620.57817222
73Pancreatic secretion_Homo sapiens_hsa049720.56750948
74Osteoclast differentiation_Homo sapiens_hsa043800.56173605
75Hippo signaling pathway_Homo sapiens_hsa043900.55005386
76Lysosome_Homo sapiens_hsa041420.54912395
77Toxoplasmosis_Homo sapiens_hsa051450.54668423
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53741289
79FoxO signaling pathway_Homo sapiens_hsa040680.53505867
80Hepatitis B_Homo sapiens_hsa051610.53032721
81Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.52256180
82Renin-angiotensin system_Homo sapiens_hsa046140.50716344
83Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48858583
84Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47000674
85Arachidonic acid metabolism_Homo sapiens_hsa005900.46240800
86Chemical carcinogenesis_Homo sapiens_hsa052040.46113510
87Tuberculosis_Homo sapiens_hsa051520.45607639
88Thyroid hormone synthesis_Homo sapiens_hsa049180.43390325
89Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42936978
90Melanoma_Homo sapiens_hsa052180.41364439
91Dorso-ventral axis formation_Homo sapiens_hsa043200.40157911
92MicroRNAs in cancer_Homo sapiens_hsa052060.36249931
93Rap1 signaling pathway_Homo sapiens_hsa040150.35780563
94Staphylococcus aureus infection_Homo sapiens_hsa051500.34783156
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.33753143
96Platelet activation_Homo sapiens_hsa046110.32915745
97Cyanoamino acid metabolism_Homo sapiens_hsa004600.32592234
98Thyroid cancer_Homo sapiens_hsa052160.32160961
99MAPK signaling pathway_Homo sapiens_hsa040100.31900383
100Fructose and mannose metabolism_Homo sapiens_hsa000510.30607659

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