CXCL8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of vitamin D biosynthetic process (GO:0060556)6.95876796
2positive regulation of heat generation (GO:0031652)6.65755804
3regulation of fever generation (GO:0031620)6.62896826
4response to peptidoglycan (GO:0032494)6.07535441
5regulation of vitamin metabolic process (GO:0030656)5.51212542
6negative regulation of interleukin-12 production (GO:0032695)5.31379702
7lipopolysaccharide-mediated signaling pathway (GO:0031663)5.27486360
8positive regulation of chemokine biosynthetic process (GO:0045080)5.24649304
9regulation of heat generation (GO:0031650)5.15647252
10regulation of chemokine biosynthetic process (GO:0045073)4.86458558
11positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.58518151
12positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.54264959
13positive regulation of NF-kappaB import into nucleus (GO:0042346)4.45205503
14regulation of podosome assembly (GO:0071801)4.42506429
15positive regulation of membrane protein ectodomain proteolysis (GO:0051044)4.31355448
16positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)4.08702928
17positive regulation of acute inflammatory response (GO:0002675)4.07218865
18regulation of mononuclear cell migration (GO:0071675)4.06997897
19cellular extravasation (GO:0045123)4.04287486
20regulation of cytokine secretion involved in immune response (GO:0002739)4.00314218
21macrophage activation involved in immune response (GO:0002281)3.96985936
22positive regulation of nitric oxide biosynthetic process (GO:0045429)3.84560729
23germinal center formation (GO:0002467)3.80682192
24positive regulation by organism of defense response of other organism involved in symbiotic interact3.79104941
25modulation by symbiont of host immune response (GO:0052553)3.79104941
26positive regulation by symbiont of host defense response (GO:0052509)3.79104941
27modulation by symbiont of host defense response (GO:0052031)3.79104941
28modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.79104941
29modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.79104941
30regulation of membrane protein ectodomain proteolysis (GO:0051043)3.78009938
31positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.72038821
32regulation of chronic inflammatory response (GO:0002676)3.71161541
33detection of molecule of bacterial origin (GO:0032490)3.69799617
34T-helper 1 type immune response (GO:0042088)3.66223283
35positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.65701563
36regulation of NF-kappaB import into nucleus (GO:0042345)3.62078230
37regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.61638544
38regulation of T-helper 2 cell differentiation (GO:0045628)3.61435453
39monocyte chemotaxis (GO:0002548)3.54892714
40regulation of nitric oxide biosynthetic process (GO:0045428)3.49085203
41response to muramyl dipeptide (GO:0032495)3.47433632
42negative regulation of lipid storage (GO:0010888)3.46645879
43response to protozoan (GO:0001562)3.46179413
44negative regulation of cytokine production involved in immune response (GO:0002719)3.43644388
45positive regulation of type 2 immune response (GO:0002830)3.42498926
46positive regulation of interleukin-6 production (GO:0032755)3.41660545
47regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.41569643
48regulation of vascular endothelial growth factor production (GO:0010574)3.39156631
49regulation of interferon-alpha production (GO:0032647)3.34787474
50neutrophil activation involved in immune response (GO:0002283)3.34444986
51regulation of T-helper 1 cell differentiation (GO:0045625)3.33332674
52neutrophil mediated immunity (GO:0002446)3.32038438
53regulation of interleukin-8 biosynthetic process (GO:0045414)3.31709376
54* cellular response to lipopolysaccharide (GO:0071222)3.31329019
55regulation of interferon-beta biosynthetic process (GO:0045357)3.30356340
56leukocyte aggregation (GO:0070486)3.29423637
57NIK/NF-kappaB signaling (GO:0038061)3.29235058
58regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.27798850
59regulation of heterotypic cell-cell adhesion (GO:0034114)3.26320412
60* cellular response to molecule of bacterial origin (GO:0071219)3.25074955
61defense response to protozoan (GO:0042832)3.24523104
62positive regulation of transcription factor import into nucleus (GO:0042993)3.23762843
63positive regulation of gamma-delta T cell activation (GO:0046645)3.22580533
64positive regulation of toll-like receptor signaling pathway (GO:0034123)3.20704474
65negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.14657860
66branching involved in labyrinthine layer morphogenesis (GO:0060670)3.09402389
67negative regulation of myeloid cell apoptotic process (GO:0033033)3.08317886
68response to manganese ion (GO:0010042)3.06323480
69positive regulation of chemokine production (GO:0032722)3.04586081
70positive regulation vascular endothelial growth factor production (GO:0010575)3.00859401
71macrophage activation (GO:0042116)2.99665154
72positive regulation of interferon-alpha production (GO:0032727)2.96051608
73modulation of growth of symbiont involved in interaction with host (GO:0044144)2.95821063
74regulation of growth of symbiont in host (GO:0044126)2.95821063
75negative regulation of growth of symbiont in host (GO:0044130)2.95821063
76negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.95821063
77regulation of interleukin-6 production (GO:0032675)2.94952679
78* neutrophil chemotaxis (GO:0030593)2.94253271
79positive regulation of T-helper cell differentiation (GO:0045624)2.91519470
80regulation of prostaglandin secretion (GO:0032306)2.91060777
81immunoglobulin mediated immune response (GO:0016064)2.89004250
82regulation of interleukin-12 production (GO:0032655)2.86685464
83positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.86383961
84* neutrophil migration (GO:1990266)2.86078257
85regulation of interleukin-12 biosynthetic process (GO:0045075)2.84749216
86* cellular response to biotic stimulus (GO:0071216)2.84304911
87cellular response to nicotine (GO:0071316)2.81410808
88regulation of immunoglobulin secretion (GO:0051023)2.81063954
89negative regulation of production of molecular mediator of immune response (GO:0002701)2.79949898
90regulation of T-helper cell differentiation (GO:0045622)2.74825906
91negative regulation of cell killing (GO:0031342)2.74405791
92negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.74405791
93cellular response to type I interferon (GO:0071357)2.74286675
94type I interferon signaling pathway (GO:0060337)2.74286675
95positive regulation of prostaglandin secretion (GO:0032308)2.73756824
96positive regulation of interferon-beta production (GO:0032728)2.73593478
97response to ATP (GO:0033198)2.73405695
98positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.73142932
99decidualization (GO:0046697)2.72778223
100oligosaccharide catabolic process (GO:0009313)2.72315048

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.33164743
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.55858057
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.39883020
4RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human4.26113751
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.72443298
6IRF8_27001747_Chip-Seq_BMDM_Mouse3.69739826
7EGR1_19374776_ChIP-ChIP_THP-1_Human3.51419799
8NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.41380192
9Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.40330194
10MYB_21317192_ChIP-Seq_ERMYB_Mouse3.25649813
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.19125224
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.08387497
13NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.02781083
14SMAD_19615063_ChIP-ChIP_OVARY_Human2.98290214
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.90537965
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.90450072
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.75633841
18STAT4_19710469_ChIP-ChIP_TH1__Mouse2.56316114
19STAT6_21828071_ChIP-Seq_BEAS2B_Human2.45664918
20IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.39934033
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.36885220
22VDR_24787735_ChIP-Seq_THP-1_Human2.31990683
23STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.22561946
24GATA1_22025678_ChIP-Seq_K562_Human2.13574895
25BRD4_27068464_Chip-Seq_AML-cells_Mouse2.06766498
26VDR_24763502_ChIP-Seq_THP-1_Human2.00530937
27PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.88159927
28TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.87077786
29RUNX_20019798_ChIP-Seq_JUKART_Human1.85922194
30SPI1_23547873_ChIP-Seq_NB4_Human1.79985385
31SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.79890606
32SPI1_23127762_ChIP-Seq_K562_Human1.79549266
33RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.76239902
34NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.67833876
35TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.67080045
36PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.65158420
37PU_27001747_Chip-Seq_BMDM_Mouse1.61227589
38SCL_19346495_ChIP-Seq_HPC-7_Human1.58142413
39CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.56890431
40ESR2_21235772_ChIP-Seq_MCF-7_Human1.56506746
41VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.47272817
42RUNX1_22412390_ChIP-Seq_EML_Mouse1.47119607
43GATA2_21666600_ChIP-Seq_HMVEC_Human1.46347805
44VDR_21846776_ChIP-Seq_THP-1_Human1.44984830
45MYB_26560356_Chip-Seq_TH2_Human1.34681271
46CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.32552316
47MAF_26560356_Chip-Seq_TH1_Human1.31016680
48FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.29979322
49TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.29801150
50KDM2B_26808549_Chip-Seq_SUP-B15_Human1.29781262
51MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.29104153
52CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.27231520
53JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.26653039
54ESR1_21235772_ChIP-Seq_MCF-7_Human1.25684096
55FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.25145247
56CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.24980740
57JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.24603648
58E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.24064352
59TCF7_22412390_ChIP-Seq_EML_Mouse1.23360305
60KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.22155638
61KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.22155638
62KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.22155638
63LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.20722301
64ELK3_25401928_ChIP-Seq_HUVEC_Human1.19103526
65PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16586474
66LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.13091942
67SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12977200
68CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11382030
69GATA1_19941826_ChIP-Seq_K562_Human1.02673625
70MYB_26560356_Chip-Seq_TH1_Human1.02055376
71PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01634843
72EGR1_19032775_ChIP-ChIP_M12_Human1.01170123
73KDM2B_26808549_Chip-Seq_DND41_Human1.00489415
74GATA3_26560356_Chip-Seq_TH2_Human1.00196620
75STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.00039993
76SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.98718101
77SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.98718101
78SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.98654582
79TP63_17297297_ChIP-ChIP_HaCaT_Human0.98440694
80GATA2_22383799_ChIP-Seq_G1ME_Mouse0.98091086
81GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.97880740
82UTX_26944678_Chip-Seq_JUKART_Human0.95825022
83GATA1_19941827_ChIP-Seq_MEL_Mouse0.95670499
84CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.93067024
85SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.92835832
86SALL4_18804426_ChIP-ChIP_XEN_Mouse0.92830418
87ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.90775757
88KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.90238894
89UBF1/2_26484160_Chip-Seq_HMECs_Human0.87643212
90FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.85597702
91GATA3_27048872_Chip-Seq_THYMUS_Human0.84860495
92LXR_22158963_ChIP-Seq_LIVER_Mouse0.84051796
93TFEB_21752829_ChIP-Seq_HELA_Human0.83009646
94CLOCK_20551151_ChIP-Seq_293T_Human0.82002606
95SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80731341
96SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.80344483
97GATA2_19941826_ChIP-Seq_K562_Human0.79238489
98SOX2_20726797_ChIP-Seq_SW620_Human0.78863441
99THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.78149367
100RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.76645797

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation6.32489204
2MP0003436_decreased_susceptibility_to3.87426815
3MP0003724_increased_susceptibility_to3.74961140
4MP0009785_altered_susceptibility_to3.39338845
5MP0002148_abnormal_hypersensitivity_rea3.26389198
6MP0006082_CNS_inflammation3.13942197
7MP0008004_abnormal_stomach_pH2.97587907
8MP0009764_decreased_sensitivity_to2.94288127
9MP0004510_myositis2.70859548
10MP0009278_abnormal_bone_marrow2.68177642
11MP0002419_abnormal_innate_immunity2.65782358
12MP0005000_abnormal_immune_tolerance2.61568644
13MP0009840_abnormal_foam_cell2.52369968
14MP0003075_altered_response_to2.43044090
15MP0005167_abnormal_blood-brain_barrier2.41718727
16MP0003300_gastrointestinal_ulcer2.35404382
17MP0001835_abnormal_antigen_presentation2.29672902
18MP0005025_abnormal_response_to2.25014585
19MP0004947_skin_inflammation2.23961438
20MP0001533_abnormal_skeleton_physiology2.21338566
21MP0000343_altered_response_to2.19586618
22MP0005387_immune_system_phenotype2.09632646
23MP0001790_abnormal_immune_system2.09632646
24MP0005671_abnormal_response_to2.04471081
25MP0002332_abnormal_exercise_endurance2.02763086
26MP0002452_abnormal_antigen_presenting1.99039623
27MP0002723_abnormal_immune_serum1.96227789
28MP0005058_abnormal_lysosome_morphology1.92668212
29MP0010352_gastrointestinal_tract_polyps1.87895006
30MP0005166_decreased_susceptibility_to1.87827820
31MP0002139_abnormal_hepatobiliary_system1.85342764
32MP0001800_abnormal_humoral_immune1.81678007
33MP0001853_heart_inflammation1.81321159
34MP0002998_abnormal_bone_remodeling1.78666973
35MP0003195_calcinosis1.72601823
36MP0005397_hematopoietic_system_phenotyp1.69416653
37MP0001545_abnormal_hematopoietic_system1.69416653
38MP0001845_abnormal_inflammatory_respons1.68597872
39MP0003656_abnormal_erythrocyte_physiolo1.68044112
40MP0010155_abnormal_intestine_physiology1.63735201
41MP0003448_altered_tumor_morphology1.60516552
42MP0005451_abnormal_body_composition1.58745878
43MP0002420_abnormal_adaptive_immunity1.58605232
44MP0001819_abnormal_immune_cell1.58374407
45MP0002254_reproductive_system_inflammat1.58298964
46MP0002405_respiratory_system_inflammati1.53528638
47MP0008469_abnormal_protein_level1.53454418
48MP0005164_abnormal_response_to1.50888202
49MP0003453_abnormal_keratinocyte_physiol1.49980402
50MP0005464_abnormal_platelet_physiology1.45048032
51MP0000685_abnormal_immune_system1.40859481
52MP0003172_abnormal_lysosome_physiology1.40203244
53MP0003191_abnormal_cellular_cholesterol1.39867925
54MP0006054_spinal_hemorrhage1.35909217
55MP0000858_altered_metastatic_potential1.35560105
56MP0003690_abnormal_glial_cell1.34257830
57MP0000604_amyloidosis1.28312014
58MP0009333_abnormal_splenocyte_physiolog1.24026759
59MP0003828_pulmonary_edema1.16623198
60MP0009765_abnormal_xenobiotic_induced1.15751125
61MP0000716_abnormal_immune_system1.07833955
62MP0005390_skeleton_phenotype1.03606423
63MP0005310_abnormal_salivary_gland1.02741207
64MP0009763_increased_sensitivity_to1.02256616
65MP0003806_abnormal_nucleotide_metabolis0.98615599
66MP0002877_abnormal_melanocyte_morpholog0.97919609
67MP0003091_abnormal_cell_migration0.96617026
68MP0003045_fibrosis0.94856186
69MP0005023_abnormal_wound_healing0.93218847
70MP0002006_tumorigenesis0.92467853
71MP0004808_abnormal_hematopoietic_stem0.88037238
72MP0002398_abnormal_bone_marrow0.87731854
73MP0001501_abnormal_sleep_pattern0.85566152
74MP0001727_abnormal_embryo_implantation0.83612103
75MP0000249_abnormal_blood_vessel0.82623637
76MP0000920_abnormal_myelination0.81534660
77MP0002429_abnormal_blood_cell0.80128827
78MP0001663_abnormal_digestive_system0.78261288
79MP0000750_abnormal_muscle_regeneration0.78249643
80MP0005165_increased_susceptibility_to0.77106632
81MP0005076_abnormal_cell_differentiation0.75935524
82MP0005535_abnormal_body_temperature0.75890490
83MP0003646_muscle_fatigue0.74962956
84MP0008874_decreased_physiological_sensi0.74147185
85MP0008260_abnormal_autophagy0.74036281
86MP0002138_abnormal_hepatobiliary_system0.72003312
87MP0000465_gastrointestinal_hemorrhage0.71884392
88MP0002722_abnormal_immune_system0.69375952
89MP0000689_abnormal_spleen_morphology0.68442764
90MP0003221_abnormal_cardiomyocyte_apopto0.68032837
91MP0003795_abnormal_bone_structure0.68013672
92MP0005647_abnormal_sex_gland0.67192757
93MP0004883_abnormal_blood_vessel0.66942777
94MP0000371_diluted_coat_color0.65157182
95MP0001851_eye_inflammation0.64106129
96MP0003705_abnormal_hypodermis_morpholog0.59707032
97MP0002933_joint_inflammation0.59038596
98MP0001542_abnormal_bone_strength0.57907008
99MP0004484_altered_response_of0.53212269
100MP0002277_abnormal_respiratory_mucosa0.53026938

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of liposaccharide metabolism (HP:0010968)6.19819254
2Abnormality of glycosphingolipid metabolism (HP:0004343)6.19819254
3Abnormality of glycolipid metabolism (HP:0010969)6.19819254
4Optic neuritis (HP:0100653)5.53361505
5Retrobulbar optic neuritis (HP:0100654)5.53361505
6Orchitis (HP:0100796)5.48846781
7Abnormality of macrophages (HP:0004311)5.45994467
8Stomatitis (HP:0010280)5.09420826
9Myositis (HP:0100614)4.83485464
10Recurrent bacterial skin infections (HP:0005406)4.79029357
11Mediastinal lymphadenopathy (HP:0100721)4.43506882
12Eczematoid dermatitis (HP:0000976)4.40608190
13Recurrent abscess formation (HP:0002722)4.25526974
14Vacuolated lymphocytes (HP:0001922)4.25284439
15Keratoconjunctivitis sicca (HP:0001097)3.88410377
16Increased cerebral lipofuscin (HP:0011813)3.78643195
17Loss of speech (HP:0002371)3.78399358
18Elevated erythrocyte sedimentation rate (HP:0003565)3.68742678
19Recurrent gram-negative bacterial infections (HP:0005420)3.63824107
20Dysostosis multiplex (HP:0000943)3.61029367
21Autoimmune thrombocytopenia (HP:0001973)3.54805600
22Keratoconjunctivitis (HP:0001096)3.54151423
23Disinhibition (HP:0000734)3.44114058
24Amyloidosis (HP:0011034)3.31291130
25Neurofibrillary tangles (HP:0002185)3.22127362
26Gangrene (HP:0100758)3.12296021
27Myocardial infarction (HP:0001658)3.11311120
28Vasculitis (HP:0002633)3.05629321
29Increased neuronal autofluorescent lipopigment (HP:0002074)3.01068027
30Hematochezia (HP:0002573)2.91174737
31Systemic lupus erythematosus (HP:0002725)2.90985530
32Increased serum ferritin (HP:0003281)2.90102102
33Pulmonary infiltrates (HP:0002113)2.89202586
34Mutism (HP:0002300)2.83980404
35Abnormality of polysaccharide metabolism (HP:0011012)2.81937862
36Abnormality of glycosaminoglycan metabolism (HP:0004371)2.81937862
37Abnormality of mucopolysaccharide metabolism (HP:0011020)2.81937862
38Hemoptysis (HP:0002105)2.78063276
39Episodic fever (HP:0001954)2.68246977
40Chronic obstructive pulmonary disease (HP:0006510)2.65826917
41Obstructive lung disease (HP:0006536)2.65826917
42Arterial thrombosis (HP:0004420)2.63511782
43Nausea (HP:0002018)2.62028858
44Nuclear cataract (HP:0100018)2.60913942
45Urinary glycosaminoglycan excretion (HP:0003541)2.55057758
46Mucopolysacchariduria (HP:0008155)2.55057758
47Recurrent skin infections (HP:0001581)2.53859309
48Apathy (HP:0000741)2.48592206
49Anorexia (HP:0002039)2.46540315
50Polyneuropathy (HP:0001271)2.44996222
51Diminished motivation (HP:0000745)2.44178431
52Gastrointestinal infarctions (HP:0005244)2.42472623
53Urticaria (HP:0001025)2.36802757
54Leukocytosis (HP:0001974)2.35870882
55Recurrent fungal infections (HP:0002841)2.35484584
56Autoimmune hemolytic anemia (HP:0001890)2.33006921
57Abnormality of the pleura (HP:0002103)2.32955384
58Interstitial pulmonary disease (HP:0006530)2.32893188
59Gingivitis (HP:0000230)2.27668859
60Segmental peripheral demyelination/remyelination (HP:0003481)2.24144234
61Recurrent viral infections (HP:0004429)2.24093027
62Neuronal loss in central nervous system (HP:0002529)2.23659610
63T lymphocytopenia (HP:0005403)2.22340610
64Metaphyseal irregularity (HP:0003025)2.21843967
65Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.21206460
66Abnormality of iron homeostasis (HP:0011031)2.19623326
67Cerebral inclusion bodies (HP:0100314)2.18894464
68Encephalitis (HP:0002383)2.16267488
69Abnormality of the vasculature of the conjunctiva (HP:0008054)2.16217522
70Meningitis (HP:0001287)2.15937361
71Increased IgM level (HP:0003496)2.13061348
72Vertigo (HP:0002321)2.10830692
73Abnormality of the pericardium (HP:0001697)2.09674543
74Abnormality of T cell number (HP:0011839)2.08551195
75Joint swelling (HP:0001386)2.07877664
76Progressive neurologic deterioration (HP:0002344)2.05791382
77Petechiae (HP:0000967)2.04752590
78Glomerulopathy (HP:0100820)2.04388937
79Abnormality of the endocardium (HP:0004306)2.04307721
80Tetraparesis (HP:0002273)2.01854911
81Axonal loss (HP:0003447)1.99448622
82Malnutrition (HP:0004395)1.98766070
83Pulmonary embolism (HP:0002204)1.97851398
84Glomerulonephritis (HP:0000099)1.97397578
85Increased IgE level (HP:0003212)1.96636155
86Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.94197716
87Acne (HP:0001061)1.92049839
88Thin bony cortex (HP:0002753)1.91775510
89Keratitis (HP:0000491)1.91468648
90Hepatosplenomegaly (HP:0001433)1.89805922
91Arthralgia (HP:0002829)1.89433746
92Increased CSF protein (HP:0002922)1.88349623
93Asymmetric septal hypertrophy (HP:0001670)1.87724647
94Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.87044845
95Parakeratosis (HP:0001036)1.86861535
96Premature loss of primary teeth (HP:0006323)1.86739469
97Inappropriate behavior (HP:0000719)1.85411733
98Slow saccadic eye movements (HP:0000514)1.85291171
99Hypergammaglobulinemia (HP:0010702)1.80174828
100Purpura (HP:0000979)1.78827536

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK37.53702079
2MAP3K143.81677845
3DDR22.99149960
4MATK2.91295101
5IRAK42.85559371
6TAOK22.63045890
7GRK72.59708141
8TBK12.49858892
9BMPR22.43357750
10RIPK42.27830149
11IKBKE2.24718441
12NME22.17746988
13IKBKB2.15382065
14BLK2.12420533
15FGR2.01682362
16PRPF4B1.97011903
17MAP3K31.93509553
18IRAK21.92212724
19CSK1.88213835
20TAOK11.85231605
21TYK21.79947452
22IRAK11.78810605
23TXK1.73406694
24MAP3K131.66896810
25MAP3K111.63723923
26MAP2K31.60015495
27MAP4K11.59173918
28MOS1.55533300
29CHUK1.51045464
30CDC42BPA1.40722484
31ZAP701.40339090
32STK241.32337543
33ERN11.31994288
34MAP3K11.31806266
35RIPK11.25542837
36TGFBR21.21534165
37ADRBK21.20766497
38ACVR1B1.20295130
39SIK31.17368788
40TAOK31.14940947
41JAK31.10543698
42JAK11.09210095
43LATS20.97937137
44TYRO30.96145128
45ABL20.93625149
46PIM20.92015198
47JAK20.91321194
48ARAF0.89402570
49MAP3K50.88665676
50MARK30.87009234
51LYN0.81721460
52PDGFRA0.73625035
53KSR20.69689376
54HCK0.63942070
55SYK0.58845930
56PDGFRB0.55803736
57EPHB10.54852318
58LCK0.51837678
59PDK20.51603729
60STK100.51222430
61MAP3K90.50217022
62KSR10.46058623
63DAPK20.44902407
64EPHA30.42395945
65DYRK30.40954036
66MAPK40.40795457
67PIM10.39004273
68CLK10.35072399
69MAPK70.34959855
70CSF1R0.34930688
71KIT0.33608974
72TTN0.33413405
73RPS6KL10.33253566
74RPS6KC10.33253566
75PDPK10.32682957
76MAP2K60.30744364
77ABL10.30513887
78PDK10.28866612
79TESK20.27899838
80GSK3A0.27646615
81CDK60.26415939
82STK38L0.26386086
83SIK10.26339962
84PAK40.25961261
85RPS6KA60.25237624
86NEK90.23723693
87BTK0.23410577
88INSR0.20569859
89PRKAA20.20254478
90RPS6KA10.19963921
91FES0.18870958
92HIPK20.18574922
93PKN10.18189404
94BMX0.18037468
95FYN0.16034833
96CAMK1D0.15493150
97SIK20.15034311
98PRKG20.14292525
99EGFR0.13752373
100PRKCD0.13601397

Predicted pathways (KEGG)

RankGene SetZ-score
1* NOD-like receptor signaling pathway_Homo sapiens_hsa046213.06686155
2* Legionellosis_Homo sapiens_hsa051342.97879690
3TNF signaling pathway_Homo sapiens_hsa046682.95112780
4* Toll-like receptor signaling pathway_Homo sapiens_hsa046202.91486959
5* Rheumatoid arthritis_Homo sapiens_hsa053232.86767075
6Leishmaniasis_Homo sapiens_hsa051402.83659494
7Osteoclast differentiation_Homo sapiens_hsa043802.75646060
8* NF-kappa B signaling pathway_Homo sapiens_hsa040642.65977117
9* Malaria_Homo sapiens_hsa051442.50499584
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.31712936
11Graft-versus-host disease_Homo sapiens_hsa053322.28734006
12* Pertussis_Homo sapiens_hsa051332.16518756
13Tuberculosis_Homo sapiens_hsa051522.11003739
14African trypanosomiasis_Homo sapiens_hsa051432.08884843
15* Salmonella infection_Homo sapiens_hsa051322.06983812
16Staphylococcus aureus infection_Homo sapiens_hsa051501.95419354
17Other glycan degradation_Homo sapiens_hsa005111.91489232
18* Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.87276014
19* RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.86346551
20Allograft rejection_Homo sapiens_hsa053301.81871450
21* Influenza A_Homo sapiens_hsa051641.76327063
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.71362807
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.70746365
24Type I diabetes mellitus_Homo sapiens_hsa049401.69845547
25Asthma_Homo sapiens_hsa053101.65294632
26Lysosome_Homo sapiens_hsa041421.63643338
27* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.62093830
28Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.55757748
29Hematopoietic cell lineage_Homo sapiens_hsa046401.55153879
30Toxoplasmosis_Homo sapiens_hsa051451.53520260
31Measles_Homo sapiens_hsa051621.46508718
32Prion diseases_Homo sapiens_hsa050201.45530205
33Intestinal immune network for IgA production_Homo sapiens_hsa046721.33800597
34* Chemokine signaling pathway_Homo sapiens_hsa040621.33391516
35* Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.31620856
36B cell receptor signaling pathway_Homo sapiens_hsa046621.30154512
37Jak-STAT signaling pathway_Homo sapiens_hsa046301.28244156
38Herpes simplex infection_Homo sapiens_hsa051681.26434444
39* Amoebiasis_Homo sapiens_hsa051461.21525774
40* AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.18488607
41Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.17313334
42Glycosaminoglycan degradation_Homo sapiens_hsa005311.17145285
43Autoimmune thyroid disease_Homo sapiens_hsa053201.15933144
44Phagosome_Homo sapiens_hsa041451.14740076
45* Hepatitis B_Homo sapiens_hsa051611.13968972
46* Hepatitis C_Homo sapiens_hsa051601.12241238
47Acute myeloid leukemia_Homo sapiens_hsa052210.99399771
48Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.98864745
49Adipocytokine signaling pathway_Homo sapiens_hsa049200.98665324
50* Shigellosis_Homo sapiens_hsa051310.98161051
51* Bladder cancer_Homo sapiens_hsa052190.93823502
52Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.89537765
53T cell receptor signaling pathway_Homo sapiens_hsa046600.88416018
54Apoptosis_Homo sapiens_hsa042100.87008116
55Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.87004822
56Prolactin signaling pathway_Homo sapiens_hsa049170.86196344
57Antigen processing and presentation_Homo sapiens_hsa046120.84658958
58VEGF signaling pathway_Homo sapiens_hsa043700.84045012
59Type II diabetes mellitus_Homo sapiens_hsa049300.74907140
60Viral myocarditis_Homo sapiens_hsa054160.69792793
61Complement and coagulation cascades_Homo sapiens_hsa046100.67892165
62Neurotrophin signaling pathway_Homo sapiens_hsa047220.66739158
63Sphingolipid signaling pathway_Homo sapiens_hsa040710.60757889
64HIF-1 signaling pathway_Homo sapiens_hsa040660.60331630
65Collecting duct acid secretion_Homo sapiens_hsa049660.58859826
66Mineral absorption_Homo sapiens_hsa049780.57944354
67Sphingolipid metabolism_Homo sapiens_hsa006000.57846980
68Renal cell carcinoma_Homo sapiens_hsa052110.56536910
69Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56267010
70Epstein-Barr virus infection_Homo sapiens_hsa051690.55704516
71Dorso-ventral axis formation_Homo sapiens_hsa043200.55519292
72Chronic myeloid leukemia_Homo sapiens_hsa052200.55386175
73Pancreatic cancer_Homo sapiens_hsa052120.53954139
74Insulin resistance_Homo sapiens_hsa049310.42781001
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.40773374
76SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40345255
77* Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40059240
78FoxO signaling pathway_Homo sapiens_hsa040680.39728031
79MAPK signaling pathway_Homo sapiens_hsa040100.38639385
80Notch signaling pathway_Homo sapiens_hsa043300.38391036
81Leukocyte transendothelial migration_Homo sapiens_hsa046700.36721621
82Small cell lung cancer_Homo sapiens_hsa052220.36293550
83Viral carcinogenesis_Homo sapiens_hsa052030.32748036
84Fatty acid biosynthesis_Homo sapiens_hsa000610.32462789
85HTLV-I infection_Homo sapiens_hsa051660.30870627
86Proteoglycans in cancer_Homo sapiens_hsa052050.30555081
87GnRH signaling pathway_Homo sapiens_hsa049120.30444013
88PPAR signaling pathway_Homo sapiens_hsa033200.30098396
89Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.29570286
90Platelet activation_Homo sapiens_hsa046110.28171786
91ErbB signaling pathway_Homo sapiens_hsa040120.27511266
92Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.25797819
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.25588178
94Non-small cell lung cancer_Homo sapiens_hsa052230.24937067
95Vibrio cholerae infection_Homo sapiens_hsa051100.24579031
96Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.24074980
97mTOR signaling pathway_Homo sapiens_hsa041500.23065305
98Prostate cancer_Homo sapiens_hsa052150.22829557
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.22205401
100Galactose metabolism_Homo sapiens_hsa000520.21580367

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