CXCL9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This antimicrobial gene encodes a protein thought to be involved in T cell trafficking. The encoded protein binds to C-X-C motif chemokine 3 and is a chemoattractant for lymphocytes but not for neutrophils. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)7.07063361
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)7.07063361
3antigen processing and presentation of endogenous antigen (GO:0019883)6.95809893
4response to type I interferon (GO:0034340)6.35620791
5type I interferon signaling pathway (GO:0060337)6.32901856
6cellular response to type I interferon (GO:0071357)6.32901856
7regulation of T cell tolerance induction (GO:0002664)6.11609637
8positive regulation of interferon-alpha production (GO:0032727)5.55565836
9positive regulation of type I interferon-mediated signaling pathway (GO:0060340)5.29384427
10regulation of interferon-alpha production (GO:0032647)5.21175068
11natural killer cell mediated immunity (GO:0002228)5.20368541
12natural killer cell mediated cytotoxicity (GO:0042267)5.20368541
13production of molecular mediator involved in inflammatory response (GO:0002532)5.19824452
14regulation of tolerance induction (GO:0002643)5.18247859
15regulation of chronic inflammatory response (GO:0002676)4.93419433
16kynurenine metabolic process (GO:0070189)4.93110184
17positive regulation of tolerance induction (GO:0002645)4.88697150
18regulation of dendritic cell antigen processing and presentation (GO:0002604)4.87487333
19positive regulation of T-helper cell differentiation (GO:0045624)4.80170973
20positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)4.79580242
21interferon-gamma-mediated signaling pathway (GO:0060333)4.77678758
22tryptophan catabolic process (GO:0006569)4.68174333
23indole-containing compound catabolic process (GO:0042436)4.68174333
24indolalkylamine catabolic process (GO:0046218)4.68174333
25positive regulation of antigen processing and presentation (GO:0002579)4.64199978
26negative regulation of viral genome replication (GO:0045071)4.58272594
27response to interferon-alpha (GO:0035455)4.57392732
28cellular response to exogenous dsRNA (GO:0071360)4.38388897
29negative regulation of interleukin-12 production (GO:0032695)4.38070707
30immunoglobulin mediated immune response (GO:0016064)4.31963933
31negative regulation of interleukin-10 production (GO:0032693)4.30961559
32cellular response to interferon-beta (GO:0035458)4.28706740
33positive regulation of toll-like receptor signaling pathway (GO:0034123)4.19750324
34eosinophil chemotaxis (GO:0048245)4.19573430
35regulation of interleukin-12 production (GO:0032655)4.15123848
36positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)4.14925572
37regulation of antigen processing and presentation (GO:0002577)4.13799638
38response to interferon-beta (GO:0035456)4.12249198
39cellular response to interferon-alpha (GO:0035457)4.10182588
40superoxide anion generation (GO:0042554)4.07846453
41positive regulation of Cdc42 GTPase activity (GO:0043089)4.05997945
42cellular response to interferon-gamma (GO:0071346)3.99989520
43regulation of macrophage chemotaxis (GO:0010758)3.95861695
44regulation of type I interferon-mediated signaling pathway (GO:0060338)3.93790108
45positive regulation of type 2 immune response (GO:0002830)3.93761510
46response to interferon-gamma (GO:0034341)3.93081426
47regulation of T-helper cell differentiation (GO:0045622)3.92923340
48cellular response to virus (GO:0098586)3.92656384
49regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.90649861
50hydrogen peroxide biosynthetic process (GO:0050665)3.87512009
51regulation of interferon-beta biosynthetic process (GO:0045357)3.86731278
52regulation of type 2 immune response (GO:0002828)3.84001894
53lymphocyte chemotaxis (GO:0048247)3.81883000
54positive regulation by symbiont of host defense response (GO:0052509)3.80363558
55modulation by symbiont of host defense response (GO:0052031)3.80363558
56modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.80363558
57modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.80363558
58positive regulation by organism of defense response of other organism involved in symbiotic interact3.80363558
59modulation by symbiont of host immune response (GO:0052553)3.80363558
60positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.79385799
61tryptophan metabolic process (GO:0006568)3.78378176
62dendritic cell chemotaxis (GO:0002407)3.75173768
63regulation of interleukin-10 production (GO:0032653)3.74905958
64* positive regulation of cAMP-mediated signaling (GO:0043950)3.72152053
65eosinophil migration (GO:0072677)3.71891375
66positive regulation of interferon-beta production (GO:0032728)3.70243213
67antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.69823506
68T cell migration (GO:0072678)3.68955905
69T-helper 1 type immune response (GO:0042088)3.65961358
70respiratory burst (GO:0045730)3.60924747
71detection of other organism (GO:0098543)3.56755266
72regulation of interleukin-1 beta secretion (GO:0050706)3.55733472
73regulation of hypersensitivity (GO:0002883)3.54748456
74myeloid dendritic cell differentiation (GO:0043011)3.50982227
75positive regulation of interleukin-1 beta secretion (GO:0050718)3.48827066
76leukocyte mediated cytotoxicity (GO:0001909)3.47073982
77positive regulation of neutrophil chemotaxis (GO:0090023)3.46792923
78positive regulation of neutrophil migration (GO:1902624)3.46792923
79regulation of T-helper 1 cell differentiation (GO:0045625)3.40461768
80positive regulation of interleukin-10 production (GO:0032733)3.39492448
81regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.38768442
82regulation of vitamin D biosynthetic process (GO:0060556)3.38735933
83positive regulation of gamma-delta T cell activation (GO:0046645)3.38463099
84reactive oxygen species biosynthetic process (GO:1903409)3.37716237
85regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.36324446
86regulation of T-helper 1 type immune response (GO:0002825)3.36119957
87detection of bacterium (GO:0016045)3.29478843
88NIK/NF-kappaB signaling (GO:0038061)3.29172368
89positive regulation of interleukin-1 secretion (GO:0050716)3.27766781
90* defense response to virus (GO:0051607)3.27379455
91intracellular pH reduction (GO:0051452)3.26958336
92positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.26184507
93positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.25389973
94regulation of inflammatory response to antigenic stimulus (GO:0002861)3.25021393
95negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.24686321
96B cell mediated immunity (GO:0019724)3.24535500
97positive regulation of natural killer cell differentiation (GO:0032825)3.24224595
98regulation of interleukin-1 secretion (GO:0050704)3.20834615
99positive regulation of granulocyte chemotaxis (GO:0071624)3.16466389
100interferon-gamma secretion (GO:0072643)3.15522571
101JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.15004205
102superoxide metabolic process (GO:0006801)3.14609937
103regulation of toll-like receptor signaling pathway (GO:0034121)3.14000756
104positive regulation of interleukin-12 production (GO:0032735)3.11385880
105regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.10636864
106positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.09668103
107positive regulation of defense response to virus by host (GO:0002230)3.09435439
108low-density lipoprotein particle clearance (GO:0034383)3.08846384
109amine catabolic process (GO:0009310)3.08812899
110cellular biogenic amine catabolic process (GO:0042402)3.08812899
111negative regulation of cell killing (GO:0031342)3.08381975
112negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.08381975
113positive regulation of monocyte chemotaxis (GO:0090026)3.07013336
114regulation of vitamin metabolic process (GO:0030656)3.05921314
115positive regulation of T cell cytokine production (GO:0002726)3.05615363
116detection of molecule of bacterial origin (GO:0032490)3.03743224
117regulation of granulocyte chemotaxis (GO:0071622)3.02931579
118regulation of interferon-gamma biosynthetic process (GO:0045072)3.02278407
119response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.00686970
120response to host immune response (GO:0052572)3.00686970
121lymphocyte mediated immunity (GO:0002449)2.98498119
122negative regulation of myeloid cell apoptotic process (GO:0033033)2.97389909
123lipopolysaccharide-mediated signaling pathway (GO:0031663)2.96383092
124regulation of cholesterol storage (GO:0010885)2.95692477
125regulation of RIG-I signaling pathway (GO:0039535)2.94340550
126myeloid dendritic cell activation (GO:0001773)2.92296235
127positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.91128652
128defense response to protozoan (GO:0042832)2.89020909
129response to peptidoglycan (GO:0032494)2.83294252
130dendritic cell differentiation (GO:0097028)2.81894892
131antigen processing and presentation via MHC class Ib (GO:0002475)2.81292172
132response to muramyl dipeptide (GO:0032495)2.80459534
133regulation of response to interferon-gamma (GO:0060330)2.79232888
134positive regulation of heat generation (GO:0031652)2.79171559
135cell killing (GO:0001906)2.77673113
136negative regulation of B cell proliferation (GO:0030889)2.76747271
137regulation of mononuclear cell migration (GO:0071675)2.75372425
138neutrophil activation involved in immune response (GO:0002283)2.73719340
139plasma lipoprotein particle clearance (GO:0034381)2.72993958
140arginine catabolic process (GO:0006527)2.71504031
141macrophage activation involved in immune response (GO:0002281)2.71058610
142positive regulation of cytokine-mediated signaling pathway (GO:0001961)2.70207135
143regulation of interleukin-8 biosynthetic process (GO:0045414)2.70095234
144microglial cell activation (GO:0001774)2.67348793
145positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.61080789
146response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.58620367
147response to host (GO:0075136)2.58620367
148response to host defenses (GO:0052200)2.58620367
149pH reduction (GO:0045851)2.58534035
150regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.56626160
151regulation of fever generation (GO:0031620)2.56436026
152regulation of interferon-beta production (GO:0032648)2.54925374
153negative regulation of viral process (GO:0048525)2.53969119
154regulation of activation of Janus kinase activity (GO:0010533)2.53411354
155regulation of defense response to virus by host (GO:0050691)2.52015897
156positive regulation of T-helper 1 type immune response (GO:0002827)2.51741501
157JAK-STAT cascade (GO:0007259)2.49973245

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF1_21803131_ChIP-Seq_MONOCYTES_Human6.90624867
2IRF8_22096565_ChIP-ChIP_GC-B_Human6.81697990
3IRF8_21731497_ChIP-ChIP_J774_Mouse6.25803721
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.18503851
5IRF8_27001747_Chip-Seq_BMDM_Mouse3.97054114
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.13801624
7GATA1_22025678_ChIP-Seq_K562_Human3.12965735
8BP1_19119308_ChIP-ChIP_Hs578T_Human3.10104574
9NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.90101654
10* ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.90052237
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.85820021
12Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.83417960
13* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.63707693
14SMAD_19615063_ChIP-ChIP_OVARY_Human2.48718520
15STAT4_19710469_ChIP-ChIP_TH1__Mouse2.42174955
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.34954163
17FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.34572709
18STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.34247929
19* EGR1_23403033_ChIP-Seq_LIVER_Mouse2.31629655
20* RXR_22158963_ChIP-Seq_LIVER_Mouse2.24414294
21LXR_22158963_ChIP-Seq_LIVER_Mouse2.18121258
22PPARA_22158963_ChIP-Seq_LIVER_Mouse2.05512115
23STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.00710777
24STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.90134427
25NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.89656283
26NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.84597045
27MYB_21317192_ChIP-Seq_ERMYB_Mouse1.84487505
28PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.77728266
29MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.74171466
30TRIM28_21343339_ChIP-Seq_HEK293_Human1.71286830
31THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.63636789
32VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.60145505
33FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.59442787
34CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.57570606
35GATA2_21666600_ChIP-Seq_HMVEC_Human1.40218269
36VDR_24787735_ChIP-Seq_THP-1_Human1.37352250
37BRD4_27068464_Chip-Seq_AML-cells_Mouse1.34343688
38CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.33997232
39* EGR1_19032775_ChIP-ChIP_M12_Human1.33675825
40PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.32995110
41SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.29888486
42RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.26599421
43EGR1_19374776_ChIP-ChIP_THP-1_Human1.24704042
44PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24189322
45SCL_19346495_ChIP-Seq_HPC-7_Human1.22472548
46PU_27001747_Chip-Seq_BMDM_Mouse1.22257755
47MAF_26560356_Chip-Seq_TH1_Human1.11429096
48NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.10120773
49SOX2_20726797_ChIP-Seq_SW620_Human1.09923718
50CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.09095704
51STAT1_20625510_ChIP-Seq_HELA_Human1.07360297
52* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.05797102
53RUNX_20019798_ChIP-Seq_JUKART_Human1.04914144
54MYB_26560356_Chip-Seq_TH2_Human1.04377314
55TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04154309
56LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.03795560
57BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.02643599
58LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.00820084
59CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00223930
60FOXO3_23340844_ChIP-Seq_DLD1_Human0.98525814
61SPI1_23127762_ChIP-Seq_K562_Human0.98025830
62NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.97461282
63NRF2_20460467_ChIP-Seq_MEFs_Mouse0.97461282
64CLOCK_20551151_ChIP-Seq_293T_Human0.95177789
65MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.94497135
66NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.93497980
67VDR_21846776_ChIP-Seq_THP-1_Human0.91313720
68FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.90263469
69LXR_22292898_ChIP-Seq_THP-1_Human0.87137683
70VDR_24763502_ChIP-Seq_THP-1_Human0.84292808
71GATA3_26560356_Chip-Seq_TH2_Human0.82409937
72TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.80928696
73GATA1_19941826_ChIP-Seq_K562_Human0.79201853
74BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.78945763
75ESR1_21235772_ChIP-Seq_MCF-7_Human0.76608774
76RUNX1_22412390_ChIP-Seq_EML_Mouse0.76581429
77GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.76572145
78CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.76459280
79VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.76407022
80SPI1_23547873_ChIP-Seq_NB4_Human0.76296974
81PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.75312616
82CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.74868961
83SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.74037534
84SOX2_27498859_Chip-Seq_STOMACH_Mouse0.73763638
85CDX2_19796622_ChIP-Seq_MESCs_Mouse0.73576125
86GATA3_27048872_Chip-Seq_THYMUS_Human0.72722061
87IKZF1_21737484_ChIP-ChIP_HCT116_Human0.72206755
88MYB_26560356_Chip-Seq_TH1_Human0.71012288
89TFEB_21752829_ChIP-Seq_HELA_Human0.70496179
90CJUN_26792858_Chip-Seq_BT549_Human0.70428930
91UTX_26944678_Chip-Seq_JUKART_Human0.70363466
92FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.70175577
93STAT6_21828071_ChIP-Seq_BEAS2B_Human0.70138246
94P63_26484246_Chip-Seq_KERATINOCYTES_Human0.69891235
95CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.69281793
96GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.69218752
97ELK3_25401928_ChIP-Seq_HUVEC_Human0.68859960
98CDX2_20551321_ChIP-Seq_CACO-2_Human0.67886970
99KDM2B_26808549_Chip-Seq_SUP-B15_Human0.67255008
100ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.67187245
101TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.67119467
102SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.66304178
103GATA2_22383799_ChIP-Seq_G1ME_Mouse0.65669285
104ESR2_21235772_ChIP-Seq_MCF-7_Human0.64056496
105RXR_22108803_ChIP-Seq_LS180_Human0.63901978
106TCF7_22412390_ChIP-Seq_EML_Mouse0.62928252
107GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.61629336
108MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.61451795
109GATA1_22383799_ChIP-Seq_G1ME_Mouse0.61347794
110PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.61046794
111CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.59813172
112RARG_19884340_ChIP-ChIP_MEFs_Mouse0.59692196
113JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.58653954
114FOXA2_19822575_ChIP-Seq_HepG2_Human0.57803957
115GATA2_19941826_ChIP-Seq_K562_Human0.57548871
116KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.57436134
117GATA1_19941827_ChIP-Seq_MEL_Mouse0.57143452
118E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.56817558
119JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.56191627
120CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.56073891
121SALL4_18804426_ChIP-ChIP_XEN_Mouse0.55188706
122KDM2B_26808549_Chip-Seq_DND41_Human0.54414247
123TP63_23658742_ChIP-Seq_EP156T_Human0.53500948
124GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.53293531

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004510_myositis4.45215836
2MP0001835_abnormal_antigen_presentation4.21869109
3MP0003303_peritoneal_inflammation3.37105995
4MP0003724_increased_susceptibility_to3.17469899
5MP0009785_altered_susceptibility_to3.17279628
6MP0001790_abnormal_immune_system2.94102588
7MP0005387_immune_system_phenotype2.94102588
8MP0000685_abnormal_immune_system2.92102502
9MP0005671_abnormal_response_to2.78618944
10MP0003436_decreased_susceptibility_to2.78483159
11MP0006082_CNS_inflammation2.78294261
12MP0005025_abnormal_response_to2.70314489
13MP0005058_abnormal_lysosome_morphology2.66741646
14MP0009840_abnormal_foam_cell2.41470810
15MP0002148_abnormal_hypersensitivity_rea2.38637117
16MP0005000_abnormal_immune_tolerance2.30668559
17MP0002419_abnormal_innate_immunity2.30531077
18MP0002254_reproductive_system_inflammat2.06183406
19* MP0001800_abnormal_humoral_immune2.00780299
20MP0009764_decreased_sensitivity_to1.97473074
21MP0001533_abnormal_skeleton_physiology1.94684952
22* MP0002452_abnormal_antigen_presenting1.93826364
23* MP0002723_abnormal_immune_serum1.89570753
24MP0001853_heart_inflammation1.89055821
25MP0003448_altered_tumor_morphology1.88441223
26MP0003075_altered_response_to1.87762768
27MP0004947_skin_inflammation1.86002920
28MP0002139_abnormal_hepatobiliary_system1.84855705
29MP0005360_urolithiasis1.82086461
30MP0003191_abnormal_cellular_cholesterol1.81911850
31MP0000604_amyloidosis1.78622870
32MP0003300_gastrointestinal_ulcer1.76882774
33MP0004858_abnormal_nervous_system1.71852880
34MP0002138_abnormal_hepatobiliary_system1.66111407
35MP0008469_abnormal_protein_level1.65205314
36MP0003183_abnormal_peptide_metabolism1.65086759
37MP0002277_abnormal_respiratory_mucosa1.63412520
38MP0005464_abnormal_platelet_physiology1.61601459
39MP0002166_altered_tumor_susceptibility1.58552983
40* MP0001819_abnormal_immune_cell1.56101701
41MP0000343_altered_response_to1.51937726
42MP0005310_abnormal_salivary_gland1.49981140
43MP0003806_abnormal_nucleotide_metabolis1.49682402
44* MP0002420_abnormal_adaptive_immunity1.49499383
45* MP0001845_abnormal_inflammatory_respons1.45289550
46MP0003172_abnormal_lysosome_physiology1.44680015
47MP0010155_abnormal_intestine_physiology1.42272661
48MP0004782_abnormal_surfactant_physiolog1.42244973
49MP0003941_abnormal_skin_development1.41057898
50MP0005164_abnormal_response_to1.37465618
51MP0003453_abnormal_keratinocyte_physiol1.35426859
52MP0003186_abnormal_redox_activity1.29039633
53MP0003690_abnormal_glial_cell1.28450380
54MP0003045_fibrosis1.28381059
55MP0000569_abnormal_digit_pigmentation1.23201365
56MP0009278_abnormal_bone_marrow1.22808602
57MP0001851_eye_inflammation1.22496189
58MP0002998_abnormal_bone_remodeling1.20798018
59MP0005085_abnormal_gallbladder_physiolo1.17344407
60MP0005365_abnormal_bile_salt1.15330556
61MP0005451_abnormal_body_composition1.15104551
62MP0005167_abnormal_blood-brain_barrier1.11355862
63MP0000716_abnormal_immune_system1.09135344
64MP0009763_increased_sensitivity_to1.06430390
65MP0002006_tumorigenesis1.06371795
66MP0005397_hematopoietic_system_phenotyp1.03684028
67MP0001545_abnormal_hematopoietic_system1.03684028
68MP0010329_abnormal_lipoprotein_level1.02437969
69MP0000609_abnormal_liver_physiology1.01155142
70MP0003329_amyloid_beta_deposits1.00818282
71MP0005319_abnormal_enzyme/_coenzyme1.00231308
72MP0003705_abnormal_hypodermis_morpholog0.99318122
73MP0009333_abnormal_splenocyte_physiolog0.97975623
74MP0005166_decreased_susceptibility_to0.96491453
75MP0002971_abnormal_brown_adipose0.96335381
76MP0009115_abnormal_fat_cell0.96228085
77MP0010307_abnormal_tumor_latency0.95459645
78MP0002877_abnormal_melanocyte_morpholog0.94638968
79MP0002405_respiratory_system_inflammati0.94143625
80MP0008260_abnormal_autophagy0.93808092
81MP0001881_abnormal_mammary_gland0.91802272
82MP0008875_abnormal_xenobiotic_pharmacok0.91670069
83MP0002876_abnormal_thyroid_physiology0.91182499
84MP0010234_abnormal_vibrissa_follicle0.88952546
85MP0005083_abnormal_biliary_tract0.88351938
86MP0002398_abnormal_bone_marrow0.88284631
87MP0009765_abnormal_xenobiotic_induced0.86916505
88MP0001873_stomach_inflammation0.86797002
89MP0003091_abnormal_cell_migration0.86736693
90MP0008775_abnormal_heart_ventricle0.84260898
91MP0003252_abnormal_bile_duct0.83635874
92MP0000858_altered_metastatic_potential0.83162769
93MP0003866_abnormal_defecation0.82232895
94MP0005248_abnormal_Harderian_gland0.81496937
95MP0005390_skeleton_phenotype0.81372878
96MP0002118_abnormal_lipid_homeostasis0.80570273
97MP0002429_abnormal_blood_cell0.80417346
98MP0000920_abnormal_myelination0.80252440
99MP0005076_abnormal_cell_differentiation0.79640154
100MP0000249_abnormal_blood_vessel0.79516830
101MP0010352_gastrointestinal_tract_polyps0.78594117
102MP0005332_abnormal_amino_acid0.78320440
103MP0002722_abnormal_immune_system0.77594930
104MP0003763_abnormal_thymus_physiology0.75116519
105MP0006054_spinal_hemorrhage0.75112481
106MP0001663_abnormal_digestive_system0.74102011
107MP0000465_gastrointestinal_hemorrhage0.73107115
108MP0005584_abnormal_enzyme/coenzyme_acti0.71516921
109MP0002136_abnormal_kidney_physiology0.71515320
110MP0000689_abnormal_spleen_morphology0.70858854
111MP0003566_abnormal_cell_adhesion0.70792910
112MP0002332_abnormal_exercise_endurance0.70437480
113MP0008004_abnormal_stomach_pH0.69430731
114MP0004883_abnormal_blood_vessel0.69384545
115MP0005334_abnormal_fat_pad0.69280725
116MP0000371_diluted_coat_color0.68015278
117MP0005023_abnormal_wound_healing0.67816435
118MP0008438_abnormal_cutaneous_collagen0.67597791
119MP0003195_calcinosis0.66513931
120MP0000015_abnormal_ear_pigmentation0.65433295
121MP0001348_abnormal_lacrimal_gland0.63319851
122MP0002693_abnormal_pancreas_physiology0.63072793
123MP0008874_decreased_physiological_sensi0.62732618
124MP0002933_joint_inflammation0.59814619
125MP0005165_increased_susceptibility_to0.58161429
126MP0003828_pulmonary_edema0.57114760

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.78229783
2Recurrent bacterial skin infections (HP:0005406)5.78784543
3Recurrent gram-negative bacterial infections (HP:0005420)5.75697644
4Recurrent abscess formation (HP:0002722)5.50081605
5Chronic otitis media (HP:0000389)5.22640119
6Systemic lupus erythematosus (HP:0002725)5.00082069
7Abnormality of macrophages (HP:0004311)4.73560660
8Gastrointestinal infarctions (HP:0005244)4.69684416
9Elevated erythrocyte sedimentation rate (HP:0003565)4.55411721
10Abnormality of liposaccharide metabolism (HP:0010968)4.49925439
11Abnormality of glycolipid metabolism (HP:0010969)4.49925439
12Tetraparesis (HP:0002273)4.21954109
13Recurrent skin infections (HP:0001581)4.10629508
14Hemoptysis (HP:0002105)3.93529245
15Increased cerebral lipofuscin (HP:0011813)3.89867103
16Nasal polyposis (HP:0100582)3.87032372
17Autoimmune thrombocytopenia (HP:0001973)3.80864390
18Abnormality of the nasal mucosa (HP:0000433)3.74098486
19Malnutrition (HP:0004395)3.68520414
20Myositis (HP:0100614)3.62169803
21Thick nail (HP:0001805)3.59712780
22Gingivitis (HP:0000230)3.53852805
23Obstructive lung disease (HP:0006536)3.52398821
24Chronic obstructive pulmonary disease (HP:0006510)3.52398821
25Interstitial pulmonary disease (HP:0006530)3.46673449
26Pulmonary infiltrates (HP:0002113)3.46075577
27Recurrent fungal infections (HP:0002841)3.45121945
28Basal ganglia calcification (HP:0002135)3.37341393
29Complement deficiency (HP:0004431)3.36258536
30Mediastinal lymphadenopathy (HP:0100721)3.34156216
31Loss of speech (HP:0002371)3.29801933
32Increased IgE level (HP:0003212)3.27477937
33Chronic mucocutaneous candidiasis (HP:0002728)3.20569941
34Recurrent cutaneous fungal infections (HP:0011370)3.20569941
35Keratoconjunctivitis sicca (HP:0001097)3.18017670
36Recurrent viral infections (HP:0004429)3.17913398
37Glomerulonephritis (HP:0000099)3.11349902
38Gangrene (HP:0100758)3.10194665
39Myocardial infarction (HP:0001658)3.10055261
40Increased neuronal autofluorescent lipopigment (HP:0002074)3.04791929
41Amyloidosis (HP:0011034)3.01394969
42Hypergammaglobulinemia (HP:0010702)3.01197052
43Prolonged neonatal jaundice (HP:0006579)3.00394905
44Spontaneous hematomas (HP:0007420)2.94717724
45Increased IgM level (HP:0003496)2.93012648
46Vacuolated lymphocytes (HP:0001922)2.92242999
47Joint hemorrhage (HP:0005261)2.89943434
48Keratoconjunctivitis (HP:0001096)2.87558986
49Hematochezia (HP:0002573)2.86082194
50Chest pain (HP:0100749)2.85993780
51Urticaria (HP:0001025)2.83401269
52Abnormality of proline metabolism (HP:0010907)2.82853871
53Hydroxyprolinuria (HP:0003080)2.82853871
54Vasculitis (HP:0002633)2.81140479
55Orchitis (HP:0100796)2.78714150
56Porencephaly (HP:0002132)2.78315865
57Abnormality of complement system (HP:0005339)2.76943033
58Premature loss of primary teeth (HP:0006323)2.73169190
59Prostate neoplasm (HP:0100787)2.72728740
60Chronic sinusitis (HP:0011109)2.67698098
61Meningitis (HP:0001287)2.67288639
62Nephritis (HP:0000123)2.66592093
63Xanthomatosis (HP:0000991)2.64766073
64Abnormality of the prostate (HP:0008775)2.60620675
65Neurofibrillary tangles (HP:0002185)2.59338957
66Abnormality of glutamine family amino acid metabolism (HP:0010902)2.55669151
67Pustule (HP:0200039)2.54862268
68Cellulitis (HP:0100658)2.52080151
69Gingival bleeding (HP:0000225)2.46466391
70Amaurosis fugax (HP:0100576)2.46309627
71Arterial thrombosis (HP:0004420)2.42848665
72Encephalitis (HP:0002383)2.42246587
73Recurrent bronchitis (HP:0002837)2.41872895
74Deep venous thrombosis (HP:0002625)2.41017077
75Hypertensive crisis (HP:0100735)2.37574671
76Esophageal varix (HP:0002040)2.36103084
77Esophageal neoplasm (HP:0100751)2.33517918
78Neoplasm of head and neck (HP:0012288)2.33517918
79Recurrent pneumonia (HP:0006532)2.31104350
80Recurrent lower respiratory tract infections (HP:0002783)2.30824853
81Stomatitis (HP:0010280)2.29535815
82Disinhibition (HP:0000734)2.29022785
83Abnormality of the pleura (HP:0002103)2.27384256
84Hyperlipoproteinemia (HP:0010980)2.27204781
85Anorexia (HP:0002039)2.24394066
86Albinism (HP:0001022)2.22232452
87Hepatosplenomegaly (HP:0001433)2.21354472
88Global brain atrophy (HP:0002283)2.20904339
89Conjunctival telangiectasia (HP:0000524)2.19527243
90Emphysema (HP:0002097)2.19229906
91Colitis (HP:0002583)2.18404219
92Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.18182003
93Periodontitis (HP:0000704)2.17523301
94Abnormality of T cell number (HP:0011839)2.17356986
95Osteomyelitis (HP:0002754)2.16981384
96Purpura (HP:0000979)2.16370701
97Leukocytosis (HP:0001974)2.16113838
98Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.14703525
99Peritonitis (HP:0002586)2.14074574
100Dysostosis multiplex (HP:0000943)2.13561269
101Urinary glycosaminoglycan excretion (HP:0003541)2.12960514
102Mucopolysacchariduria (HP:0008155)2.12960514
103Thin bony cortex (HP:0002753)2.11243688
104Axonal loss (HP:0003447)2.10605854
105Prolonged partial thromboplastin time (HP:0003645)2.09753247
106IgA deficiency (HP:0002720)2.09546236
107Intrahepatic cholestasis (HP:0001406)2.08698502
108Abnormality of the endocardium (HP:0004306)2.07832212
109Increased serum ferritin (HP:0003281)2.07372529
110Autoimmune hemolytic anemia (HP:0001890)2.07244007
111Lower limb hyperreflexia (HP:0002395)2.05178390
112Stomach cancer (HP:0012126)2.04009894
113Cheilitis (HP:0100825)2.03417114
114T lymphocytopenia (HP:0005403)2.03396250
115Bone pain (HP:0002653)2.03389766
116Epidermoid cyst (HP:0200040)2.03125156
117Abnormality of the vasculature of the conjunctiva (HP:0008054)2.02501400
118Joint swelling (HP:0001386)2.01273966
119Abnormality of the common coagulation pathway (HP:0010990)2.00484163
120Retrobulbar optic neuritis (HP:0100654)1.98236963
121Optic neuritis (HP:0100653)1.98236963
122Gastrointestinal stroma tumor (HP:0100723)1.98078481
123Inflammation of the large intestine (HP:0002037)1.96367928
124Abnormal delayed hypersensitivity skin test (HP:0002963)1.96354596
125Abnormality of the pericardium (HP:0001697)1.95830368
126Abnormality of aromatic amino acid family metabolism (HP:0004338)1.95412154
127Restrictive lung disease (HP:0002091)1.95406679
128Abnormality of mucopolysaccharide metabolism (HP:0011020)1.94815965
129Abnormality of polysaccharide metabolism (HP:0011012)1.94815965
130Abnormality of glycosaminoglycan metabolism (HP:0004371)1.94815965
131Abnormality of iron homeostasis (HP:0011031)1.94732908
132Cerebral inclusion bodies (HP:0100314)1.94066131
133Chronic diarrhea (HP:0002028)1.93254670
134Skin ulcer (HP:0200042)1.93203506
135Pulmonary embolism (HP:0002204)1.93143087
136Hypophosphatemia (HP:0002148)1.92939518
137Progressive visual loss (HP:0000529)1.91789574
138Abnormality of T cell physiology (HP:0011840)1.91551505
139Abnormality of glycosphingolipid metabolism (HP:0004343)1.91375660

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK6.55042419
2TBK14.36944836
3TYK24.10543385
4IKBKE3.84114178
5FGFR43.72532755
6MAP3K143.15718890
7PIM23.02808127
8KIT2.96148165
9BLK2.83193081
10ERN12.82016031
11JAK12.80977466
12IRAK42.69315129
13TAOK32.52303747
14DDR22.45089471
15EPHB12.26840196
16JAK32.26200172
17EPHA32.20836870
18FGFR32.02712556
19PRPF4B2.02365366
20CDC42BPA1.88326453
21IRAK31.70903422
22DYRK1B1.70205099
23RIPK41.57795509
24IKBKB1.46250613
25MAP3K51.45951139
26IRAK11.32600405
27DMPK1.27141963
28JAK21.16650935
29CHUK1.11780921
30CSK1.10499369
31TAOK21.08952281
32ABL21.08601140
33FGR1.07552331
34CDK61.01304390
35STK40.99015084
36DAPK30.91467380
37FES0.91055785
38BMX0.90110720
39MAP3K130.85967658
40LCK0.84881795
41ACVR1B0.82428706
42EIF2AK20.82204584
43RIPK10.78693817
44RPS6KA40.78221563
45MAP3K110.75066564
46EGFR0.73088280
47TESK20.72368672
48HCK0.71874992
49SYK0.71656866
50MAP3K30.70537050
51TGFBR20.70516197
52TAOK10.69299294
53PDGFRA0.69091376
54MATK0.67953458
55LYN0.67286112
56NLK0.65519960
57SIK30.63467150
58TYRO30.59783040
59GRK70.59691823
60MAP4K10.59211975
61MAPK110.58376761
62ALK0.57922756
63EPHB20.56850068
64IRAK20.56533504
65CSF1R0.56529285
66PIM10.56325380
67MAPK40.55920302
68ABL10.55404242
69FER0.54919793
70DAPK20.53124584
71PTK60.51930714
72KDR0.51444168
73PKN10.50527805
74ZAP700.50088145
75SIK10.48538515
76TXK0.48412508
77CAMK1D0.47658050
78MST1R0.45168899
79TIE10.39566538
80ERBB20.39045726
81MAP3K120.38632637
82RPS6KA20.37477757
83STK100.37401347
84MAP2K30.37085858
85CLK10.37009662
86MAP3K10.36866694
87PRKG20.35665898
88PDK20.35414701
89RPS6KA50.34274168
90PDGFRB0.34028341
91HIPK20.33972597
92PRKCD0.33564325
93BTK0.33423804
94FYN0.33097308
95CDK40.32998702
96YES10.32295842
97MOS0.31886550
98PIK3CG0.30788233
99MAPKAPK20.30054395
100PRKCQ0.29459601
101NUAK10.29215663
102MAPK70.28986089
103BMPR20.28551653
104PDK10.28543000
105GSK3A0.27689370
106RPS6KL10.27408011
107RPS6KC10.27408011
108CAMK1G0.27235416
109TNK20.26518236
110PRKAA20.24835373
111CAMK2G0.24468069
112SRC0.24210964
113ITK0.24150626
114MARK30.22984122
115INSR0.22773202
116PHKG10.21923039
117PHKG20.21923039
118ERBB40.21683059
119RPS6KA60.20182216
120MST40.18880609
121TEC0.18783797
122SGK10.18559869
123MAPK30.17913864
124PDPK10.17901737
125LRRK20.17870288
126NME20.17593920
127LATS20.17051518
128RET0.16053001
129NEK90.15264667
130ADRBK20.14518415
131IGF1R0.13300409
132TTN0.12935616

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.79334857
2Type I diabetes mellitus_Homo sapiens_hsa049403.24771146
3Leishmaniasis_Homo sapiens_hsa051402.65800512
4* Toll-like receptor signaling pathway_Homo sapiens_hsa046202.59686707
5RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.41544108
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.30507931
7Arginine biosynthesis_Homo sapiens_hsa002202.24722053
8Osteoclast differentiation_Homo sapiens_hsa043802.16586299
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.16318226
10Pertussis_Homo sapiens_hsa051332.03781181
11Complement and coagulation cascades_Homo sapiens_hsa046102.02788056
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.00140807
13Primary bile acid biosynthesis_Homo sapiens_hsa001201.99960734
14Measles_Homo sapiens_hsa051621.95441203
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.92387596
16Influenza A_Homo sapiens_hsa051641.87085847
17Antigen processing and presentation_Homo sapiens_hsa046121.86358026
18Intestinal immune network for IgA production_Homo sapiens_hsa046721.74754692
19Hepatitis C_Homo sapiens_hsa051601.70460972
20Tuberculosis_Homo sapiens_hsa051521.69203343
21Malaria_Homo sapiens_hsa051441.68056027
22TNF signaling pathway_Homo sapiens_hsa046681.65169538
23Toxoplasmosis_Homo sapiens_hsa051451.64384068
24Lysosome_Homo sapiens_hsa041421.50329074
25Caffeine metabolism_Homo sapiens_hsa002321.49893308
26Herpes simplex infection_Homo sapiens_hsa051681.48179465
27Allograft rejection_Homo sapiens_hsa053301.46508984
28NOD-like receptor signaling pathway_Homo sapiens_hsa046211.40234032
29African trypanosomiasis_Homo sapiens_hsa051431.39546046
30Glycosaminoglycan degradation_Homo sapiens_hsa005311.33890181
31Phagosome_Homo sapiens_hsa041451.31207646
32Jak-STAT signaling pathway_Homo sapiens_hsa046301.27312131
33Histidine metabolism_Homo sapiens_hsa003401.21660711
34Asthma_Homo sapiens_hsa053101.18238252
35* Chemokine signaling pathway_Homo sapiens_hsa040621.14401512
36Primary immunodeficiency_Homo sapiens_hsa053401.13831045
37Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.13374875
38Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.11107473
39Rheumatoid arthritis_Homo sapiens_hsa053231.10610207
40Pentose and glucuronate interconversions_Homo sapiens_hsa000401.10009954
41Hematopoietic cell lineage_Homo sapiens_hsa046401.09003864
42Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.08549806
43Salmonella infection_Homo sapiens_hsa051321.07750255
44Legionellosis_Homo sapiens_hsa051341.06611961
45Peroxisome_Homo sapiens_hsa041461.04457306
46B cell receptor signaling pathway_Homo sapiens_hsa046621.04211253
47Apoptosis_Homo sapiens_hsa042101.02545745
48Nitrogen metabolism_Homo sapiens_hsa009101.02021498
49Hepatitis B_Homo sapiens_hsa051610.99943154
50* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.98640664
51Prolactin signaling pathway_Homo sapiens_hsa049170.98408530
52PPAR signaling pathway_Homo sapiens_hsa033200.98330345
53Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.94692139
54Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.92707381
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.91748165
56Tryptophan metabolism_Homo sapiens_hsa003800.88279358
57Shigellosis_Homo sapiens_hsa051310.82927211
58ABC transporters_Homo sapiens_hsa020100.82590501
59Systemic lupus erythematosus_Homo sapiens_hsa053220.80521301
60Viral myocarditis_Homo sapiens_hsa054160.80250684
61Autoimmune thyroid disease_Homo sapiens_hsa053200.77196630
62Adipocytokine signaling pathway_Homo sapiens_hsa049200.77003848
63AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.71401802
64Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.70811007
65Graft-versus-host disease_Homo sapiens_hsa053320.70510666
66Amoebiasis_Homo sapiens_hsa051460.70039355
67Fatty acid degradation_Homo sapiens_hsa000710.69546708
68Phenylalanine metabolism_Homo sapiens_hsa003600.69054698
69Sulfur metabolism_Homo sapiens_hsa009200.65268499
70Leukocyte transendothelial migration_Homo sapiens_hsa046700.63818537
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.63059964
72Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.61895881
73HIF-1 signaling pathway_Homo sapiens_hsa040660.60175161
74Acute myeloid leukemia_Homo sapiens_hsa052210.59931070
75Epstein-Barr virus infection_Homo sapiens_hsa051690.59662666
76Pancreatic cancer_Homo sapiens_hsa052120.58074283
77Small cell lung cancer_Homo sapiens_hsa052220.56921284
78Chemical carcinogenesis_Homo sapiens_hsa052040.55573578
79Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.54783221
80Prion diseases_Homo sapiens_hsa050200.54238536
81Mineral absorption_Homo sapiens_hsa049780.53443442
82Starch and sucrose metabolism_Homo sapiens_hsa005000.52324657
83Type II diabetes mellitus_Homo sapiens_hsa049300.46239628
84Bile secretion_Homo sapiens_hsa049760.45805465
85Renin-angiotensin system_Homo sapiens_hsa046140.45072135
86Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.43712751
87Chronic myeloid leukemia_Homo sapiens_hsa052200.42968998
88beta-Alanine metabolism_Homo sapiens_hsa004100.42330990
89Fatty acid metabolism_Homo sapiens_hsa012120.42161667
90Arginine and proline metabolism_Homo sapiens_hsa003300.40125786
91Dorso-ventral axis formation_Homo sapiens_hsa043200.40058525
92Steroid biosynthesis_Homo sapiens_hsa001000.38666184
93T cell receptor signaling pathway_Homo sapiens_hsa046600.38549335
94Insulin resistance_Homo sapiens_hsa049310.37690685
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.36521743
96Retinol metabolism_Homo sapiens_hsa008300.36153130
97Steroid hormone biosynthesis_Homo sapiens_hsa001400.35742812
98HTLV-I infection_Homo sapiens_hsa051660.34779001
99Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.34245496
100Sphingolipid metabolism_Homo sapiens_hsa006000.33311042
101Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.32505040
102Collecting duct acid secretion_Homo sapiens_hsa049660.32020834
103Other glycan degradation_Homo sapiens_hsa005110.31597680
104Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.31502753
105Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.30876959
106Fatty acid biosynthesis_Homo sapiens_hsa000610.30843023
107Sphingolipid signaling pathway_Homo sapiens_hsa040710.30799729
108Glycerolipid metabolism_Homo sapiens_hsa005610.29740637
109Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.27907072
110SNARE interactions in vesicular transport_Homo sapiens_hsa041300.27024053
111Bladder cancer_Homo sapiens_hsa052190.26660196
112Ether lipid metabolism_Homo sapiens_hsa005650.25214264
113Fat digestion and absorption_Homo sapiens_hsa049750.25176161
114Cyanoamino acid metabolism_Homo sapiens_hsa004600.25054644
115alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24688545
116Linoleic acid metabolism_Homo sapiens_hsa005910.18478437
117Galactose metabolism_Homo sapiens_hsa000520.17606836
118Notch signaling pathway_Homo sapiens_hsa043300.16796458
119Fructose and mannose metabolism_Homo sapiens_hsa000510.15694194
120Transcriptional misregulation in cancer_Homo sapiens_hsa052020.15098946
121Drug metabolism - other enzymes_Homo sapiens_hsa009830.13335542
122Arachidonic acid metabolism_Homo sapiens_hsa005900.11261784
123Glutathione metabolism_Homo sapiens_hsa004800.10801811
124Viral carcinogenesis_Homo sapiens_hsa052030.10057868
125Endocytosis_Homo sapiens_hsa041440.09382742
126Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.09256748
127Vitamin digestion and absorption_Homo sapiens_hsa049770.08547851
128Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.08519896
129Folate biosynthesis_Homo sapiens_hsa007900.07450478

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