CXCR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)7.05433670
2negative regulation of cell killing (GO:0031342)7.05433670
3protein K48-linked deubiquitination (GO:0071108)7.00378120
4Peyers patch development (GO:0048541)6.58114109
5mucosal-associated lymphoid tissue development (GO:0048537)6.58114109
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.47970240
7positive regulation by organism of defense response of other organism involved in symbiotic interact6.47970240
8modulation by symbiont of host immune response (GO:0052553)6.47970240
9positive regulation by symbiont of host defense response (GO:0052509)6.47970240
10modulation by symbiont of host defense response (GO:0052031)6.47970240
11modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.47970240
12positive regulation of developmental pigmentation (GO:0048087)5.58907511
13detection of other organism (GO:0098543)5.54489412
14protein K63-linked deubiquitination (GO:0070536)5.53440931
15neutrophil activation involved in immune response (GO:0002283)5.46093545
16protein K11-linked deubiquitination (GO:0035871)5.43956083
17detection of bacterium (GO:0016045)5.29351950
18regulation of gamma-delta T cell differentiation (GO:0045586)5.08742877
19detection of molecule of bacterial origin (GO:0032490)4.94734583
20negative regulation of erythrocyte differentiation (GO:0045647)4.93512271
21peptidyl-lysine dimethylation (GO:0018027)4.92946757
22leukocyte migration involved in inflammatory response (GO:0002523)4.92359981
23detection of external biotic stimulus (GO:0098581)4.89460356
24endosome to melanosome transport (GO:0035646)4.81030312
25endosome to pigment granule transport (GO:0043485)4.81030312
26negative regulation of lymphocyte mediated immunity (GO:0002707)4.76218128
27T-helper 1 type immune response (GO:0042088)4.67018769
28nonribosomal peptide biosynthetic process (GO:0019184)4.62732694
29neutrophil activation (GO:0042119)4.61930051
30interleukin-1-mediated signaling pathway (GO:0070498)4.61636602
31positive regulation of gamma-delta T cell activation (GO:0046645)4.61129841
32regulation of gamma-delta T cell activation (GO:0046643)4.60811635
33positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.59368390
34negative regulation of interleukin-17 production (GO:0032700)4.55460191
35cellular extravasation (GO:0045123)4.54570321
36regulation of T-helper 2 cell differentiation (GO:0045628)4.49983648
37respiratory burst (GO:0045730)4.47240224
38antigen processing and presentation via MHC class Ib (GO:0002475)4.47072844
39negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)4.44409238
40negative regulation of T-helper cell differentiation (GO:0045623)4.44409238
41response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.41973912
42response to host immune response (GO:0052572)4.41973912
43regulation of T-helper 1 cell differentiation (GO:0045625)4.40836123
44lymph node development (GO:0048535)4.28134346
45microglial cell activation (GO:0001774)4.23877340
46detection of biotic stimulus (GO:0009595)4.23778626
47secondary metabolite biosynthetic process (GO:0044550)4.16152574
48negative regulation of leukocyte mediated immunity (GO:0002704)4.13725397
49granulocyte activation (GO:0036230)4.11498683
50mature B cell differentiation involved in immune response (GO:0002313)4.08748088
51response to host (GO:0075136)4.06386230
52response to host defenses (GO:0052200)4.06386230
53response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.06386230
54neutrophil mediated immunity (GO:0002446)4.01801638
55type I interferon signaling pathway (GO:0060337)3.94441151
56cellular response to type I interferon (GO:0071357)3.94441151
57response to type I interferon (GO:0034340)3.91238481
58immunoglobulin mediated immune response (GO:0016064)3.91191145
59* response to interleukin-15 (GO:0070672)3.88517069
60growth hormone receptor signaling pathway (GO:0060396)3.88167324
61macrophage activation (GO:0042116)3.87110013
62positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.85091852
63production of molecular mediator involved in inflammatory response (GO:0002532)3.81201142
64myeloid cell activation involved in immune response (GO:0002275)3.81007366
65regulation of memory T cell differentiation (GO:0043380)3.73867333
66negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.72568958
67negative regulation of T cell mediated immunity (GO:0002710)3.72406274
68regulation of mast cell degranulation (GO:0043304)3.70870194
69positive regulation of T cell cytokine production (GO:0002726)3.70578731
70negative regulation of phagocytosis (GO:0050765)3.64764444
71regulation of regulatory T cell differentiation (GO:0045589)3.63934139
72peptidyl-threonine dephosphorylation (GO:0035970)3.59872158
73response to interferon-beta (GO:0035456)3.59809724
74negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.58276849
75adaptation of signaling pathway (GO:0023058)3.57472390
76positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.55293020
77head development (GO:0060322)3.51066085
78antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.48658117
79antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.48658117
80regulation of myeloid leukocyte mediated immunity (GO:0002886)3.48353587
81regulation of B cell receptor signaling pathway (GO:0050855)3.48291478
82NIK/NF-kappaB signaling (GO:0038061)3.47318840
83cellular response to prostaglandin stimulus (GO:0071379)3.46642451
84myeloid leukocyte mediated immunity (GO:0002444)3.44180008
85regulation of T cell tolerance induction (GO:0002664)3.43471248
86regulation of mast cell activation involved in immune response (GO:0033006)3.42043391
87positive regulation of T cell mediated cytotoxicity (GO:0001916)3.41243281
88B cell receptor signaling pathway (GO:0050853)3.39630817
89mature B cell differentiation (GO:0002335)3.38506127
90leukocyte degranulation (GO:0043299)3.36461669
91regulation of T cell mediated cytotoxicity (GO:0001914)3.35353550
92negative regulation of protein autophosphorylation (GO:0031953)3.35320993
93tricarboxylic acid metabolic process (GO:0072350)3.34443925
94viral transcription (GO:0019083)3.34267942
95positive regulation of mast cell activation (GO:0033005)3.34247875
96peptide biosynthetic process (GO:0043043)3.33577840
97germinal center formation (GO:0002467)3.29363704
98regulation of tolerance induction (GO:0002643)3.29305028
99regulation of interleukin-13 production (GO:0032656)3.27933475
100diterpenoid biosynthetic process (GO:0016102)3.27849979
101ribosomal small subunit assembly (GO:0000028)3.27618398
102regulation of leukocyte degranulation (GO:0043300)3.27603298
103cellular response to growth hormone stimulus (GO:0071378)3.22237984
104regulation of mast cell activation (GO:0033003)3.22025272
105regulation of developmental pigmentation (GO:0048070)3.21802261
106response to interferon-alpha (GO:0035455)3.21792067
107negative regulation of type 2 immune response (GO:0002829)3.20929235
108* cellular response to interleukin-15 (GO:0071350)3.18117656
109interferon-gamma-mediated signaling pathway (GO:0060333)3.15917577
110negative regulation of type I interferon production (GO:0032480)3.15546720
111macrophage differentiation (GO:0030225)3.15277880
112regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.15083519
113regulation of natural killer cell mediated immunity (GO:0002715)3.15083519
114B cell mediated immunity (GO:0019724)3.12728247
115amyloid precursor protein catabolic process (GO:0042987)3.12495557
116translational termination (GO:0006415)3.12242191
117regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.09976295
118ear development (GO:0043583)3.09933917
119negative regulation of alpha-beta T cell activation (GO:0046636)3.06572509
120negative regulation of innate immune response (GO:0045824)3.04990911
121fusion of sperm to egg plasma membrane (GO:0007342)3.02023790
122response to muramyl dipeptide (GO:0032495)3.01778238
123positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.01715287
124positive regulation of interferon-alpha production (GO:0032727)3.01552741
125regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.99588220
126negative regulation of interleukin-6 production (GO:0032715)2.99453188
127negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.99397894
128JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.97541462
129regulation of regulated secretory pathway (GO:1903305)2.97212199
130regulation of interferon-beta biosynthetic process (GO:0045357)2.93135050
131lipopolysaccharide-mediated signaling pathway (GO:0031663)2.92412727
132antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.91705404
133venous blood vessel morphogenesis (GO:0048845)2.91280532
134neutrophil chemotaxis (GO:0030593)2.90846639
135positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.90648455
136myeloid leukocyte activation (GO:0002274)2.90117691
137positive regulation of B cell differentiation (GO:0045579)2.90095501
138regulation of superoxide anion generation (GO:0032928)2.89476327
139regulation of alpha-beta T cell proliferation (GO:0046640)2.88741829
140leukocyte aggregation (GO:0070486)2.85587826
141negative regulation of nitric-oxide synthase activity (GO:0051001)2.84663780
142negative regulation of interleukin-12 production (GO:0032695)2.84649838
143response to peptidoglycan (GO:0032494)2.83724640
144macrophage activation involved in immune response (GO:0002281)2.83675451
145antigen processing and presentation of endogenous antigen (GO:0019883)2.83402826
146T cell homeostasis (GO:0043029)2.82972514
147positive regulation of type 2 immune response (GO:0002830)2.82071952
148positive regulation of T-helper cell differentiation (GO:0045624)2.81636515
149sulfation (GO:0051923)2.80453585
150platelet dense granule organization (GO:0060155)2.80259246
151negative regulation of alpha-beta T cell differentiation (GO:0046639)2.80099789
152regulation of immunoglobulin secretion (GO:0051023)2.78774254
153defense response to protozoan (GO:0042832)2.76613806
154pentose-phosphate shunt (GO:0006098)2.75674374
155pericardium development (GO:0060039)2.74621231
156CD4-positive, alpha-beta T cell activation (GO:0035710)2.73780956
157positive regulation of chemokine biosynthetic process (GO:0045080)2.71353399
158post-embryonic morphogenesis (GO:0009886)2.70137429
159regulation of B cell differentiation (GO:0045577)2.65872497
160negative regulation of cytokine production involved in immune response (GO:0002719)2.61510858
161positive regulation of interleukin-4 production (GO:0032753)2.61371982
162positive regulation of tolerance induction (GO:0002645)2.59159598
163translational elongation (GO:0006414)2.57169754
164response to protozoan (GO:0001562)2.56497155
165positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.54501337
166lateral ventricle development (GO:0021670)2.54168522
167positive regulation of isotype switching (GO:0045830)2.53419393
168protein autoprocessing (GO:0016540)2.51576228
169negative regulation of thymocyte apoptotic process (GO:0070244)2.51169332
170secretory granule organization (GO:0033363)2.49293573
171insulin-like growth factor receptor signaling pathway (GO:0048009)2.48993080
172gland morphogenesis (GO:0022612)2.48735186
173plasma membrane fusion (GO:0045026)2.48405463
174regulation of interleukin-17 production (GO:0032660)2.47539392
175regulation of chemokine biosynthetic process (GO:0045073)2.47398990

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse6.40444585
2RBPJ_22232070_ChIP-Seq_NCS_Mouse5.23322154
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.90625501
4STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.01558051
5RUNX_20019798_ChIP-Seq_JUKART_Human2.94153885
6SCL_19346495_ChIP-Seq_HPC-7_Human2.85016455
7RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.77723963
8BP1_19119308_ChIP-ChIP_Hs578T_Human2.72021090
9MYC_22102868_ChIP-Seq_BL_Human2.47194946
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.45534022
11TCF7_22412390_ChIP-Seq_EML_Mouse2.44007387
12MYB_21317192_ChIP-Seq_ERMYB_Mouse2.41514485
13ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.39249566
14MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.35825640
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.31092021
16SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.26118398
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.17059913
18* LXR_22292898_ChIP-Seq_THP-1_Human2.07342146
19PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.06473517
20IRF8_21731497_ChIP-ChIP_J774_Mouse2.05609512
21KDM2B_26808549_Chip-Seq_SUP-B15_Human2.02367507
22STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.01133897
23VDR_21846776_ChIP-Seq_THP-1_Human2.00306864
24NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.99686345
25LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.97565263
26FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.94972409
27SMAD_19615063_ChIP-ChIP_OVARY_Human1.92387065
28ELK3_25401928_ChIP-Seq_HUVEC_Human1.89912257
29* RXR_22158963_ChIP-Seq_LIVER_Mouse1.88506605
30ELF1_17652178_ChIP-ChIP_JURKAT_Human1.83949469
31MYB_26560356_Chip-Seq_TH2_Human1.80531556
32VDR_24763502_ChIP-Seq_THP-1_Human1.78744137
33EGR1_19374776_ChIP-ChIP_THP-1_Human1.78206720
34SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.77919928
35KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.76185581
36GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.75018678
37MYB_26560356_Chip-Seq_TH1_Human1.74970003
38MAF_26560356_Chip-Seq_TH1_Human1.72302994
39E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.69028559
40IRF8_27001747_Chip-Seq_BMDM_Mouse1.68847548
41STAT4_19710469_ChIP-ChIP_TH1__Mouse1.68322407
42GATA1_19941826_ChIP-Seq_K562_Human1.67793869
43SPI1_20517297_ChIP-Seq_HL60_Human1.65197645
44UTX_26944678_Chip-Seq_JUKART_Human1.64616315
45IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.64405317
46CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.63787308
47* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.61721380
48NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.52256807
49FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.52135832
50CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.50924344
51* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.46392511
52RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.44490829
53ZNF263_19887448_ChIP-Seq_K562_Human1.44018784
54* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.43094038
55SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.42768414
56CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.41132679
57HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.40177543
58TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.40115081
59FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.39698584
60KDM2B_26808549_Chip-Seq_DND41_Human1.38872562
61GATA1_19941827_ChIP-Seq_MEL_Mouse1.38771421
62LXR_22158963_ChIP-Seq_LIVER_Mouse1.35565155
63STAT6_21828071_ChIP-Seq_BEAS2B_Human1.34812371
64* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.34358045
65RARG_19884340_ChIP-ChIP_MEFs_Mouse1.33833392
66GATA1_22383799_ChIP-Seq_G1ME_Mouse1.31231011
67SPI1_23547873_ChIP-Seq_NB4_Human1.30036962
68GATA2_21666600_ChIP-Seq_HMVEC_Human1.28974518
69KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.28562925
70* GATA3_26560356_Chip-Seq_TH2_Human1.28454519
71BRD4_27068464_Chip-Seq_AML-cells_Mouse1.25309597
72* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23895249
73SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23478034
74CLOCK_20551151_ChIP-Seq_293T_Human1.23355975
75GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22217615
76RACK7_27058665_Chip-Seq_MCF-7_Human1.20361035
77* SA1_27219007_Chip-Seq_ERYTHROID_Human1.20193166
78IKZF1_21737484_ChIP-ChIP_HCT116_Human1.19699400
79RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18950555
80PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18588649
81KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.18057156
82IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.16669925
83VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.16409950
84GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15943802
85Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.15924212
86BCL6_27268052_Chip-Seq_Bcells_Human1.15330713
87SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14059673
88SPI1_23127762_ChIP-Seq_K562_Human1.13939007
89ESR1_21235772_ChIP-Seq_MCF-7_Human1.13913151
90PU.1_20513432_ChIP-Seq_Bcells_Mouse1.13752122
91BCOR_27268052_Chip-Seq_Bcells_Human1.13727700
92MAF_26560356_Chip-Seq_TH2_Human1.13151121
93* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13131190
94SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.09000207
95VDR_24787735_ChIP-Seq_THP-1_Human1.08891362
96FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.07184166
97GATA1_22025678_ChIP-Seq_K562_Human1.07046452
98ESR2_21235772_ChIP-Seq_MCF-7_Human1.06424680
99KDM2B_26808549_Chip-Seq_JURKAT_Human1.05272764
100ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.05041894
101VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.04282120
102PU_27001747_Chip-Seq_BMDM_Mouse1.03113585
103PPAR_26484153_Chip-Seq_NCI-H1993_Human1.01377846
104GATA3_27048872_Chip-Seq_THYMUS_Human1.01278712
105TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00901744
106RUNX1_22412390_ChIP-Seq_EML_Mouse1.00658726
107* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.98714329
108KDM2B_26808549_Chip-Seq_K562_Human0.97834390
109GATA2_19941826_ChIP-Seq_K562_Human0.97261749
110PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97033310
111ZFP281_18757296_ChIP-ChIP_E14_Mouse0.96856834
112NOTCH1_21737748_ChIP-Seq_TLL_Human0.96357249
113PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95235539
114WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.95075853
115RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93399222
116DROSHA_22980978_ChIP-Seq_HELA_Human0.92296308
117* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90357025
118SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.89018674
119NCOR1_26117541_ChIP-Seq_K562_Human0.86455744
120* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84921203
121GATA2_22383799_ChIP-Seq_G1ME_Mouse0.84813220
122MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.83864925
123STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.80160653
124SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.77518099

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003172_abnormal_lysosome_physiology3.92824945
2MP0004510_myositis3.87641810
3MP0003011_delayed_dark_adaptation3.81690902
4MP0001835_abnormal_antigen_presentation3.15523967
5MP0002396_abnormal_hematopoietic_system2.84943741
6MP0009785_altered_susceptibility_to2.76391874
7MP0003436_decreased_susceptibility_to2.70167842
8MP0003303_peritoneal_inflammation2.65700248
9MP0005464_abnormal_platelet_physiology2.63792501
10MP0006082_CNS_inflammation2.59366549
11MP0005075_abnormal_melanosome_morpholog2.54535683
12MP0000015_abnormal_ear_pigmentation2.48566189
13MP0000685_abnormal_immune_system2.46903064
14MP0006054_spinal_hemorrhage2.46096374
15MP0002132_abnormal_respiratory_system2.30167023
16MP0002089_abnormal_postnatal_growth/wei2.22503625
17MP0002234_abnormal_pharynx_morphology2.19896169
18MP0008260_abnormal_autophagy2.15914097
19MP0002277_abnormal_respiratory_mucosa2.13250493
20MP0010329_abnormal_lipoprotein_level2.10707880
21MP0004130_abnormal_muscle_cell2.07028217
22MP0002419_abnormal_innate_immunity2.07002528
23MP0005000_abnormal_immune_tolerance2.05284241
24MP0010234_abnormal_vibrissa_follicle1.99339989
25MP0003300_gastrointestinal_ulcer1.96490650
26MP0000465_gastrointestinal_hemorrhage1.91916056
27MP0005025_abnormal_response_to1.87648187
28MP0003075_altered_response_to1.83000741
29MP0005671_abnormal_response_to1.82588701
30MP0003828_pulmonary_edema1.77555009
31MP0002723_abnormal_immune_serum1.72411952
32MP0002452_abnormal_antigen_presenting1.72175150
33MP0004808_abnormal_hematopoietic_stem1.70095019
34MP0003183_abnormal_peptide_metabolism1.68424239
35MP0002420_abnormal_adaptive_immunity1.66026509
36MP0003724_increased_susceptibility_to1.65008161
37MP0002139_abnormal_hepatobiliary_system1.64833278
38MP0001819_abnormal_immune_cell1.64681060
39MP0001800_abnormal_humoral_immune1.62031569
40MP0008961_abnormal_basal_metabolism1.60124295
41MP0004381_abnormal_hair_follicle1.58727676
42MP0005085_abnormal_gallbladder_physiolo1.53602153
43MP0003868_abnormal_feces_composition1.50652070
44MP0004185_abnormal_adipocyte_glucose1.50568188
45MP0005451_abnormal_body_composition1.50114931
46MP0004883_abnormal_blood_vessel1.49845809
47MP0005397_hematopoietic_system_phenotyp1.45994333
48MP0001545_abnormal_hematopoietic_system1.45994333
49MP0005174_abnormal_tail_pigmentation1.38571175
50MP0002398_abnormal_bone_marrow1.36817511
51MP0004859_abnormal_synaptic_plasticity1.36602864
52MP0000343_altered_response_to1.35875460
53MP0002148_abnormal_hypersensitivity_rea1.34026771
54MP0009840_abnormal_foam_cell1.32190792
55MP0009333_abnormal_splenocyte_physiolog1.32131515
56MP0008469_abnormal_protein_level1.31862560
57MP0000716_abnormal_immune_system1.30489133
58MP0002095_abnormal_skin_pigmentation1.29670255
59MP0005167_abnormal_blood-brain_barrier1.26702375
60MP0002405_respiratory_system_inflammati1.25263787
61MP0005310_abnormal_salivary_gland1.24539881
62MP0002722_abnormal_immune_system1.23517245
63MP0000689_abnormal_spleen_morphology1.23326602
64MP0001853_heart_inflammation1.23106396
65MP0003448_altered_tumor_morphology1.21246222
66MP0005666_abnormal_adipose_tissue1.20911031
67MP0001790_abnormal_immune_system1.20051400
68MP0005387_immune_system_phenotype1.20051400
69MP0001845_abnormal_inflammatory_respons1.19933032
70MP0005164_abnormal_response_to1.19260755
71MP0005365_abnormal_bile_salt1.15084331
72MP0009278_abnormal_bone_marrow1.11224726
73MP0008875_abnormal_xenobiotic_pharmacok1.10744383
74MP0003690_abnormal_glial_cell1.10573449
75MP0005166_decreased_susceptibility_to1.10349251
76MP0002998_abnormal_bone_remodeling1.08147610
77MP0002429_abnormal_blood_cell1.07911504
78MP0004947_skin_inflammation1.07186866
79MP0003191_abnormal_cellular_cholesterol1.05018836
80MP0002928_abnormal_bile_duct1.03210485
81MP0001533_abnormal_skeleton_physiology1.02951269
82MP0010155_abnormal_intestine_physiology1.02895841
83MP0003866_abnormal_defecation1.02277106
84MP0000751_myopathy1.00760073
85MP0003656_abnormal_erythrocyte_physiolo0.99782857
86MP0001851_eye_inflammation0.94831383
87MP0005390_skeleton_phenotype0.94114184
88MP0005360_urolithiasis0.93047869
89MP0000371_diluted_coat_color0.92767864
90MP0001958_emphysema0.92482374
91MP0000516_abnormal_urinary_system0.90747200
92MP0005367_renal/urinary_system_phenotyp0.90747200
93MP0003045_fibrosis0.88755624
94MP0002118_abnormal_lipid_homeostasis0.87834383
95MP0009764_decreased_sensitivity_to0.87262977
96MP0008004_abnormal_stomach_pH0.86476597
97MP0000490_abnormal_crypts_of0.85990524
98MP0003638_abnormal_response/metabolism_0.84427509
99MP0000703_abnormal_thymus_morphology0.83310217
100MP0009763_increased_sensitivity_to0.82901816
101MP0004858_abnormal_nervous_system0.82593690
102MP0001666_abnormal_nutrient_absorption0.82314843
103MP0005377_hearing/vestibular/ear_phenot0.82125814
104MP0003878_abnormal_ear_physiology0.82125814
105MP0000858_altered_metastatic_potential0.81973542
106MP0001663_abnormal_digestive_system0.81890553
107MP0000598_abnormal_liver_morphology0.81533143
108MP0000249_abnormal_blood_vessel0.80761780
109MP0002166_altered_tumor_susceptibility0.80377656
110MP0005595_abnormal_vascular_smooth0.79642879
111MP0003566_abnormal_cell_adhesion0.76578676
112MP0001986_abnormal_taste_sensitivity0.74992730
113MP0008874_decreased_physiological_sensi0.74818003
114MP0003806_abnormal_nucleotide_metabolis0.74610626
115MP0004147_increased_porphyrin_level0.74589780
116MP0000604_amyloidosis0.74560960
117MP0000767_abnormal_smooth_muscle0.72734922
118MP0005023_abnormal_wound_healing0.72441406
119MP0001873_stomach_inflammation0.70102094
120MP0002909_abnormal_adrenal_gland0.68821612
121MP0009379_abnormal_foot_pigmentation0.68802666
122MP0005375_adipose_tissue_phenotype0.68459679
123MP0003763_abnormal_thymus_physiology0.68362835
124MP0003221_abnormal_cardiomyocyte_apopto0.67283513
125MP0003091_abnormal_cell_migration0.67200318
126MP0005535_abnormal_body_temperature0.66866160
127MP0005248_abnormal_Harderian_gland0.65919418
128MP0005083_abnormal_biliary_tract0.64854926
129MP0009765_abnormal_xenobiotic_induced0.64665598
130MP0003795_abnormal_bone_structure0.62481444
131MP0005319_abnormal_enzyme/_coenzyme0.57976994
132MP0002133_abnormal_respiratory_system0.57562799
133MP0005388_respiratory_system_phenotype0.57562799
134MP0002933_joint_inflammation0.57331615
135MP0002653_abnormal_ependyma_morphology0.53094197
136MP0002332_abnormal_exercise_endurance0.50062343
137MP0003252_abnormal_bile_duct0.48580338
138MP0002693_abnormal_pancreas_physiology0.46204547

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)5.21931958
2Hypochromic microcytic anemia (HP:0004840)5.12172734
3Spontaneous hematomas (HP:0007420)5.11664301
4Hematochezia (HP:0002573)4.72514413
5Gastrointestinal infarctions (HP:0005244)4.71723109
6Myositis (HP:0100614)4.69428017
7Abnormality of the nasal mucosa (HP:0000433)4.43554252
8Chronic obstructive pulmonary disease (HP:0006510)4.41407859
9Obstructive lung disease (HP:0006536)4.41407859
10Abnormal delayed hypersensitivity skin test (HP:0002963)4.26604714
11Mediastinal lymphadenopathy (HP:0100721)4.25220259
12Orchitis (HP:0100796)4.20281213
13Reduced antithrombin III activity (HP:0001976)4.19995753
14Hypochromic anemia (HP:0001931)4.08207308
15Polycythemia (HP:0001901)4.00520806
16Retrobulbar optic neuritis (HP:0100654)3.94377558
17Optic neuritis (HP:0100653)3.94377558
18Amyloidosis (HP:0011034)3.94352645
19Increased IgE level (HP:0003212)3.90407130
20Cerebral hemorrhage (HP:0001342)3.82087817
21Thrombocytosis (HP:0001894)3.75672032
22Urticaria (HP:0001025)3.75355273
23Agammaglobulinemia (HP:0004432)3.64222556
24Epistaxis (HP:0000421)3.63117814
25Chronic mucocutaneous candidiasis (HP:0002728)3.53926580
26Recurrent cutaneous fungal infections (HP:0011370)3.53926580
27Colitis (HP:0002583)3.53091285
28Hemoptysis (HP:0002105)3.52769766
29Arterial thrombosis (HP:0004420)3.48805491
30Menorrhagia (HP:0000132)3.48592500
31Panhypogammaglobulinemia (HP:0003139)3.47456035
32Albinism (HP:0001022)3.46639829
33Episodic fever (HP:0001954)3.40887641
34Prolonged bleeding time (HP:0003010)3.39749672
35Pulmonary embolism (HP:0002204)3.31574685
36Conjunctival telangiectasia (HP:0000524)3.26281981
37Thrombophlebitis (HP:0004418)3.25568306
38Abnormal platelet function (HP:0011869)3.25126067
39Impaired platelet aggregation (HP:0003540)3.25126067
40Hemorrhage of the eye (HP:0011885)3.19373962
41Recurrent gram-negative bacterial infections (HP:0005420)3.18253310
42Portal hypertension (HP:0001409)3.16000755
43Encephalitis (HP:0002383)3.13644128
44Anorexia (HP:0002039)3.08190194
45Recurrent skin infections (HP:0001581)2.94747418
46T lymphocytopenia (HP:0005403)2.94176578
47Spontaneous abortion (HP:0005268)2.90181227
48Chest pain (HP:0100749)2.89390807
49Recurrent viral infections (HP:0004429)2.89014552
50Abnormality of T cell number (HP:0011839)2.85569137
51Abnormality of the hepatic vasculature (HP:0006707)2.84118605
52Leukocytosis (HP:0001974)2.83052737
53Esophageal varix (HP:0002040)2.79256949
54Joint swelling (HP:0001386)2.77069983
55Meningitis (HP:0001287)2.76089560
56Recurrent fungal infections (HP:0002841)2.74659615
57Inflammation of the large intestine (HP:0002037)2.70391625
58Chronic hepatic failure (HP:0100626)2.67111873
59Recurrent abscess formation (HP:0002722)2.66980986
60Gingival bleeding (HP:0000225)2.66646103
61Increased IgM level (HP:0003496)2.66445495
62Chronic otitis media (HP:0000389)2.62268287
63Osteomyelitis (HP:0002754)2.62190751
64Interstitial pulmonary disease (HP:0006530)2.62123473
65Abnormality of T cells (HP:0002843)2.59110373
66Abnormality of the vasculature of the conjunctiva (HP:0008054)2.58716130
67Elevated erythrocyte sedimentation rate (HP:0003565)2.58075135
68Cellulitis (HP:0100658)2.57965981
69Keratoconjunctivitis sicca (HP:0001097)2.53431035
70Sepsis (HP:0100806)2.52294648
71Abnormality of secondary sexual hair (HP:0009888)2.52282934
72Abnormality of the axillary hair (HP:0100134)2.52282934
73Acute hepatic failure (HP:0006554)2.52223264
74Pustule (HP:0200039)2.51295404
75Gastrointestinal inflammation (HP:0004386)2.50534378
76Abnormality of the peritoneum (HP:0002585)2.50310493
77Abnormality of the pleura (HP:0002103)2.49974246
78Granulocytopenia (HP:0001913)2.48796611
79Glucose intolerance (HP:0000833)2.44292840
80Visceral angiomatosis (HP:0100761)2.43333457
81Abnormality of the intrinsic pathway (HP:0010989)2.41135768
82Gangrene (HP:0100758)2.40324490
83Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.39395274
84Joint hemorrhage (HP:0005261)2.38414583
85Recurrent bacterial skin infections (HP:0005406)2.37862457
86Eczematoid dermatitis (HP:0000976)2.35338632
87Lymphopenia (HP:0001888)2.33269246
88Bile duct proliferation (HP:0001408)2.27885575
89Abnormal biliary tract physiology (HP:0012439)2.27885575
90Hemangiomatosis (HP:0007461)2.27568666
91Toxemia of pregnancy (HP:0100603)2.27180489
92Fatigue (HP:0012378)2.26427489
93Hypergammaglobulinemia (HP:0010702)2.26024848
94Abnormality of the endocardium (HP:0004306)2.25590244
95Ocular albinism (HP:0001107)2.24895858
96Abnormality of the pericardium (HP:0001697)2.24796041
97Abnormality of the heme biosynthetic pathway (HP:0010472)2.21752346
98Keratoconjunctivitis (HP:0001096)2.21233175
99Abnormality of cells of the lymphoid lineage (HP:0012140)2.20291003
100Glomerulopathy (HP:0100820)2.19736121
101Premature skin wrinkling (HP:0100678)2.19655053
102Pulmonary infiltrates (HP:0002113)2.19454289
103Viral hepatitis (HP:0006562)2.16676171
104Increased cerebral lipofuscin (HP:0011813)2.16500141
105Acne (HP:0001061)2.16283159
106Keratitis (HP:0000491)2.16233530
107Skin ulcer (HP:0200042)2.14027991
108Amaurosis fugax (HP:0100576)2.13321408
109Retinal atrophy (HP:0001105)2.13220481
110Metaphyseal cupping (HP:0003021)2.12565393
111Deep venous thrombosis (HP:0002625)2.10763919
112Premature loss of primary teeth (HP:0006323)2.10362669
113Generalized hypopigmentation (HP:0007513)2.10039338
114Myocardial infarction (HP:0001658)2.08269892
115Gingivitis (HP:0000230)2.05627032
116Abnormal platelet volume (HP:0011876)2.04739702
117Slow saccadic eye movements (HP:0000514)2.04656641
118Eosinophilia (HP:0001880)2.04170253
119Abnormality of T cell physiology (HP:0011840)2.03094938
120Hepatosplenomegaly (HP:0001433)2.02826897
121Type I transferrin isoform profile (HP:0003642)2.02734849
122Hypoproteinemia (HP:0003075)2.00283276
123Nasal polyposis (HP:0100582)2.00132264
124IgM deficiency (HP:0002850)1.98006976
125Purpura (HP:0000979)1.97451140
126Subacute progressive viral hepatitis (HP:0006572)1.96946984
127Constricted visual fields (HP:0001133)1.95971193
128Difficulty running (HP:0009046)1.95518050
129Ridged nail (HP:0001807)1.93818807
130Pulmonary fibrosis (HP:0002206)1.92323501
131Recurrent pneumonia (HP:0006532)1.92224857
132Segmental peripheral demyelination/remyelination (HP:0003481)1.91602260
133Hypermelanotic macule (HP:0001034)1.91464248
134Microcytic anemia (HP:0001935)1.91235604
135Increased neuronal autofluorescent lipopigment (HP:0002074)1.90673572
136Cavernous hemangioma (HP:0001048)1.89869809
137Iris hypopigmentation (HP:0007730)1.89305211
138Migraine (HP:0002076)1.87502972
139Abnormality of macrophages (HP:0004311)1.86413083
140Peritonitis (HP:0002586)1.83765302
141Congenital, generalized hypertrichosis (HP:0004540)1.83289235
142Mitral stenosis (HP:0001718)1.82142596
143Abnormality of the common coagulation pathway (HP:0010990)1.81506270
144Abnormality of iron homeostasis (HP:0011031)1.81339321
145Recurrent bronchitis (HP:0002837)1.81003061
146Skin nodule (HP:0200036)1.80753354
147Skin rash (HP:0000988)1.79945330
148Cheilitis (HP:0100825)1.79798958
149Petechiae (HP:0000967)1.79737931
150Vertigo (HP:0002321)1.79095986
151Abnormal hemoglobin (HP:0011902)1.78363445
152Abnormal glucose tolerance (HP:0001952)1.75449498
153Vasculitis (HP:0002633)1.74321011

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR24.82560260
2PNCK4.66939834
3IRAK43.58476153
4TGFBR13.53104558
5MAP3K93.29888640
6MAP2K33.29845437
7CAMK1G2.95668231
8MAP3K132.85909454
9TNK22.68126784
10RIPK42.52970647
11KSR22.45544526
12MAP4K12.34415482
13BRSK22.31407247
14FLT32.30880513
15PKN22.11356708
16ZAP702.03771795
17ERN12.02578878
18ARAF1.98367276
19MAP3K31.97541115
20JAK31.92106096
21BLK1.88174600
22CSNK1A1L1.88091807
23MAP3K121.86781209
24CAMK11.77725699
25MAP2K61.75493366
26PRPF4B1.72194693
27PIK3CA1.66403126
28TXK1.64010471
29MOS1.60041379
30FGR1.51936782
31EPHB11.51642460
32SIK31.42878752
33YES11.41757939
34LRRK21.39610371
35PTK61.38480926
36EEF2K1.38427201
37WEE11.38064921
38IKBKE1.34519893
39JAK11.23797794
40BTK1.20205797
41KIT1.19213706
42MAP3K11.18594384
43MAPKAPK31.17833768
44PRKD21.11920965
45TYK21.10011464
46CSNK1G31.08863394
47MAP3K141.08811645
48MAP3K111.07856137
49CDK191.05265354
50MARK31.01752493
51FES1.01511282
52IRAK11.00476032
53MAP3K60.99341352
54SYK0.97986121
55RET0.95958530
56MUSK0.94337511
57BRSK10.94123236
58NME20.93761708
59SMG10.92390554
60ITK0.91458421
61CSF1R0.90067743
62HCK0.88232750
63RAF10.87680936
64IRAK20.86248207
65PDGFRB0.85685795
66SIK10.83995450
67TAOK20.80869027
68TESK20.80298729
69TAOK30.79829865
70STK100.77272549
71LCK0.77076621
72JAK20.74619349
73CSNK1G20.74608575
74TAOK10.73093210
75MAPK40.70877372
76CSNK1G10.70791419
77DYRK1B0.70246391
78PDK10.70087446
79EPHA30.70070669
80STK380.69596225
81TTN0.67915167
82ABL20.65412259
83ICK0.64622044
84TRIB30.62763885
85MAPK120.62471150
86MAP3K20.62338273
87TBK10.60047693
88MAP3K50.59833362
89SIK20.57400798
90FGFR30.57025836
91MARK20.56425408
92STK110.55919973
93BMPR20.55432040
94LYN0.54122048
95MAP2K40.53350251
96IKBKB0.53082474
97SGK30.52386343
98GRK60.52293935
99PRKCQ0.50760643
100PDPK10.49976826
101PRKG20.49786123
102HIPK20.49730344
103CSK0.48906180
104CDC42BPA0.48700463
105TIE10.48583449
106TEC0.48507897
107DAPK20.48313228
108RPS6KA40.48004476
109NLK0.47856692
110MST40.47585787
111NTRK10.47504442
112MAP3K70.46291979
113PIK3CG0.45330641
114PTK20.44348890
115FYN0.43139551
116EGFR0.43057635
117PRKCZ0.41997383
118ALK0.41033886
119KDR0.40765004
120MAPK70.39482352
121PIM10.38728419
122KSR10.38327142
123DYRK30.33517267
124CAMKK10.33406883
125MAP3K80.32010490
126RPS6KA60.31479635
127SGK20.31454246
128SRC0.30661558
129ERBB20.30153011
130FGFR40.29988447
131PRKCH0.29566073
132RPS6KA10.29366726
133MATK0.28825355
134MAPKAPK20.27784913
135PAK20.27609155
136RPS6KC10.26081989
137RPS6KL10.26081989
138CDK50.25504216
139PTK2B0.23080605

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000726.91121950
2Sulfur relay system_Homo sapiens_hsa041223.15324335
3Butanoate metabolism_Homo sapiens_hsa006502.49662642
4Graft-versus-host disease_Homo sapiens_hsa053322.29532982
5RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.23973249
6Allograft rejection_Homo sapiens_hsa053302.19178186
7Autoimmune thyroid disease_Homo sapiens_hsa053202.06794686
8Leishmaniasis_Homo sapiens_hsa051401.71455765
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.69632027
10Type I diabetes mellitus_Homo sapiens_hsa049401.63490359
11Platelet activation_Homo sapiens_hsa046111.63075319
12Staphylococcus aureus infection_Homo sapiens_hsa051501.61445408
13Acute myeloid leukemia_Homo sapiens_hsa052211.57434304
14Osteoclast differentiation_Homo sapiens_hsa043801.54848225
15B cell receptor signaling pathway_Homo sapiens_hsa046621.54067306
16Viral myocarditis_Homo sapiens_hsa054161.52812017
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.50662566
18Legionellosis_Homo sapiens_hsa051341.50628092
19Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.49590574
20Nitrogen metabolism_Homo sapiens_hsa009101.42832148
21Fatty acid elongation_Homo sapiens_hsa000621.40333393
22Herpes simplex infection_Homo sapiens_hsa051681.36714429
23Ribosome_Homo sapiens_hsa030101.34638456
24Pentose phosphate pathway_Homo sapiens_hsa000301.26012834
25Hematopoietic cell lineage_Homo sapiens_hsa046401.19362814
26Hepatitis C_Homo sapiens_hsa051601.18502200
27Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.17179969
28Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.10230373
29Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.09307176
30Complement and coagulation cascades_Homo sapiens_hsa046101.07146873
31Neurotrophin signaling pathway_Homo sapiens_hsa047221.06946349
32Pertussis_Homo sapiens_hsa051331.06910992
33Chronic myeloid leukemia_Homo sapiens_hsa052201.06503272
34Jak-STAT signaling pathway_Homo sapiens_hsa046301.06157529
35Toll-like receptor signaling pathway_Homo sapiens_hsa046201.04568081
36Retinol metabolism_Homo sapiens_hsa008301.03821300
37Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.03787172
38NOD-like receptor signaling pathway_Homo sapiens_hsa046211.02726295
39Shigellosis_Homo sapiens_hsa051311.00516740
40NF-kappa B signaling pathway_Homo sapiens_hsa040640.97953653
41Tuberculosis_Homo sapiens_hsa051520.97784926
42Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.97246793
43Hepatitis B_Homo sapiens_hsa051610.96973738
44Caffeine metabolism_Homo sapiens_hsa002320.96069833
45Primary immunodeficiency_Homo sapiens_hsa053400.95806400
46Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.94869755
47Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.93549628
48Primary bile acid biosynthesis_Homo sapiens_hsa001200.93251421
49Ether lipid metabolism_Homo sapiens_hsa005650.89256635
50ABC transporters_Homo sapiens_hsa020100.89206029
51* Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.88733181
52Renal cell carcinoma_Homo sapiens_hsa052110.88650505
53* Endocytosis_Homo sapiens_hsa041440.88573695
54Prolactin signaling pathway_Homo sapiens_hsa049170.87209805
55Starch and sucrose metabolism_Homo sapiens_hsa005000.87077303
56* Chemokine signaling pathway_Homo sapiens_hsa040620.86620564
57Adipocytokine signaling pathway_Homo sapiens_hsa049200.85766691
58Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.85312520
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.84423820
60Antigen processing and presentation_Homo sapiens_hsa046120.84010011
61TNF signaling pathway_Homo sapiens_hsa046680.83136293
62Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.82605906
63Arginine biosynthesis_Homo sapiens_hsa002200.82230809
64Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.81847956
65Dorso-ventral axis formation_Homo sapiens_hsa043200.79325188
66Intestinal immune network for IgA production_Homo sapiens_hsa046720.78977663
67Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.78569549
68AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.78058175
69Sphingolipid signaling pathway_Homo sapiens_hsa040710.77311297
70Type II diabetes mellitus_Homo sapiens_hsa049300.76336955
71Notch signaling pathway_Homo sapiens_hsa043300.75938040
72N-Glycan biosynthesis_Homo sapiens_hsa005100.75801959
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75664442
74Endometrial cancer_Homo sapiens_hsa052130.74231362
75FoxO signaling pathway_Homo sapiens_hsa040680.74191658
76Malaria_Homo sapiens_hsa051440.73705406
77Leukocyte transendothelial migration_Homo sapiens_hsa046700.70340406
78Bladder cancer_Homo sapiens_hsa052190.69545593
79SNARE interactions in vesicular transport_Homo sapiens_hsa041300.69256956
80Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68089760
81Viral carcinogenesis_Homo sapiens_hsa052030.67997665
82Choline metabolism in cancer_Homo sapiens_hsa052310.66486399
83Rap1 signaling pathway_Homo sapiens_hsa040150.65611612
84T cell receptor signaling pathway_Homo sapiens_hsa046600.65555067
85Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.65516569
86Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.65169256
87Measles_Homo sapiens_hsa051620.64690670
88Regulation of autophagy_Homo sapiens_hsa041400.64144682
89Epstein-Barr virus infection_Homo sapiens_hsa051690.63815556
90Phosphatidylinositol signaling system_Homo sapiens_hsa040700.63187867
91Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.63177509
92Rheumatoid arthritis_Homo sapiens_hsa053230.62756205
93African trypanosomiasis_Homo sapiens_hsa051430.62258676
94Other glycan degradation_Homo sapiens_hsa005110.62142962
95Bile secretion_Homo sapiens_hsa049760.61673722
96Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.61158586
97Insulin resistance_Homo sapiens_hsa049310.60848811
98Colorectal cancer_Homo sapiens_hsa052100.60628224
99Amoebiasis_Homo sapiens_hsa051460.60589996
100GnRH signaling pathway_Homo sapiens_hsa049120.59541824
101Fatty acid degradation_Homo sapiens_hsa000710.58857142
102Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58795545
103Lysosome_Homo sapiens_hsa041420.58221241
104Prion diseases_Homo sapiens_hsa050200.58060177
105Central carbon metabolism in cancer_Homo sapiens_hsa052300.57980260
106Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.57653881
107Carbon metabolism_Homo sapiens_hsa012000.57410335
108Salmonella infection_Homo sapiens_hsa051320.57410247
109Asthma_Homo sapiens_hsa053100.57170406
110Glioma_Homo sapiens_hsa052140.55229872
111Apoptosis_Homo sapiens_hsa042100.55036999
112Inositol phosphate metabolism_Homo sapiens_hsa005620.53704446
113* Phospholipase D signaling pathway_Homo sapiens_hsa040720.53310780
114Biosynthesis of amino acids_Homo sapiens_hsa012300.53203514
115Toxoplasmosis_Homo sapiens_hsa051450.52415920
116Glycerophospholipid metabolism_Homo sapiens_hsa005640.50725245
117mTOR signaling pathway_Homo sapiens_hsa041500.50415594
118PPAR signaling pathway_Homo sapiens_hsa033200.50009357
119Influenza A_Homo sapiens_hsa051640.49633332
120MAPK signaling pathway_Homo sapiens_hsa040100.49565764
121Phagosome_Homo sapiens_hsa041450.49127542
122HIF-1 signaling pathway_Homo sapiens_hsa040660.48690339
123HTLV-I infection_Homo sapiens_hsa051660.48482631
124* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.48471595
125VEGF signaling pathway_Homo sapiens_hsa043700.47577291
126Aldosterone synthesis and secretion_Homo sapiens_hsa049250.47518132
127Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47508050
128Insulin signaling pathway_Homo sapiens_hsa049100.47455075
129Pyruvate metabolism_Homo sapiens_hsa006200.47089258
130Cholinergic synapse_Homo sapiens_hsa047250.46294590
131Estrogen signaling pathway_Homo sapiens_hsa049150.46216846
132ErbB signaling pathway_Homo sapiens_hsa040120.46031332
133Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.42796952
134Pancreatic cancer_Homo sapiens_hsa052120.41712295
135Galactose metabolism_Homo sapiens_hsa000520.41640539
136Non-small cell lung cancer_Homo sapiens_hsa052230.41370853
137Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.40777715
138Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40086892
139Olfactory transduction_Homo sapiens_hsa047400.39759860
140Fatty acid metabolism_Homo sapiens_hsa012120.38616307
141Carbohydrate digestion and absorption_Homo sapiens_hsa049730.38390812
142Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38088913

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