CXCR2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G7.14306949
2negative regulation of cell killing (GO:0031342)6.95537311
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.95537311
4positive regulation by symbiont of host defense response (GO:0052509)6.68535706
5modulation by symbiont of host defense response (GO:0052031)6.68535706
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.68535706
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.68535706
8positive regulation by organism of defense response of other organism involved in symbiotic interact6.68535706
9modulation by symbiont of host immune response (GO:0052553)6.68535706
10antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.14462061
11antigen processing and presentation of endogenous antigen (GO:0019883)5.82652271
12positive regulation of gamma-delta T cell activation (GO:0046645)5.80985877
13antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.47060913
14macrophage activation involved in immune response (GO:0002281)5.46790254
15detection of molecule of bacterial origin (GO:0032490)5.33270242
16superoxide anion generation (GO:0042554)4.99109089
17detection of external biotic stimulus (GO:0098581)4.96468452
18positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.85762697
19response to peptidoglycan (GO:0032494)4.84668146
20negative regulation of lymphocyte mediated immunity (GO:0002707)4.75736621
21regulation of interferon-beta biosynthetic process (GO:0045357)4.72419521
22negative regulation of interleukin-12 production (GO:0032695)4.47449121
23microglial cell activation (GO:0001774)4.46329383
24positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.44748435
25leukocyte aggregation (GO:0070486)4.44433861
26leukocyte migration involved in inflammatory response (GO:0002523)4.38665316
27cellular extravasation (GO:0045123)4.34226578
28detection of biotic stimulus (GO:0009595)4.30918302
29DNA deamination (GO:0045006)4.26392450
30regulation of gamma-delta T cell activation (GO:0046643)4.19557599
31neutrophil mediated immunity (GO:0002446)4.18263016
32negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)4.18012739
33regulation of mitochondrial translation (GO:0070129)4.17562355
34natural killer cell activation involved in immune response (GO:0002323)4.14406971
35negative regulation of leukocyte mediated immunity (GO:0002704)4.09560602
36macrophage activation (GO:0042116)4.05099715
37* response to interleukin-15 (GO:0070672)3.94562146
38myeloid cell activation involved in immune response (GO:0002275)3.86137353
39kinetochore assembly (GO:0051382)3.83170580
40positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.81993883
41negative regulation of T cell mediated immunity (GO:0002710)3.80920700
42immunoglobulin mediated immune response (GO:0016064)3.75524077
43cellular response to type I interferon (GO:0071357)3.74368868
44type I interferon signaling pathway (GO:0060337)3.74368868
45regulation of nuclear cell cycle DNA replication (GO:0033262)3.74021683
46regulation of gamma-delta T cell differentiation (GO:0045586)3.72372784
47response to type I interferon (GO:0034340)3.71457386
48antigen processing and presentation via MHC class Ib (GO:0002475)3.70142840
49negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.69218375
50regulation of mast cell activation (GO:0033003)3.65948098
51negative regulation of mast cell activation (GO:0033004)3.62372114
52regulation of mast cell degranulation (GO:0043304)3.61552476
53neutrophil activation involved in immune response (GO:0002283)3.60066943
54DNA double-strand break processing (GO:0000729)3.59666475
55B cell receptor signaling pathway (GO:0050853)3.49891599
56kinetochore organization (GO:0051383)3.49612951
57* granulocyte activation (GO:0036230)3.48686317
58proteasome assembly (GO:0043248)3.48507632
59negative regulation of phagocytosis (GO:0050765)3.45301543
60defense response to fungus (GO:0050832)3.44442966
61regulation of mast cell activation involved in immune response (GO:0033006)3.41742932
62DNA replication checkpoint (GO:0000076)3.41179484
63negative regulation of T-helper cell differentiation (GO:0045623)3.39078060
64negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.39078060
65positive regulation of T cell mediated cytotoxicity (GO:0001916)3.37910490
66ribosomal small subunit biogenesis (GO:0042274)3.36560191
67leukocyte degranulation (GO:0043299)3.35883041
68telomere maintenance via semi-conservative replication (GO:0032201)3.35600175
69rRNA modification (GO:0000154)3.35197791
70DNA catabolic process, exonucleolytic (GO:0000738)3.34807336
71respiratory burst (GO:0045730)3.33621720
72DNA damage response, detection of DNA damage (GO:0042769)3.32978915
73regulation of B cell differentiation (GO:0045577)3.32844671
74deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.31821353
75regulation of T cell mediated cytotoxicity (GO:0001914)3.31442346
76ribosomal large subunit biogenesis (GO:0042273)3.30961495
77regulation of T cell tolerance induction (GO:0002664)3.30750156
78regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.28854945
79regulation of myeloid leukocyte mediated immunity (GO:0002886)3.28600808
80detection of other organism (GO:0098543)3.27698900
81* cellular response to interleukin-15 (GO:0071350)3.27115376
82regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.27030133
83regulation of T-helper 2 cell differentiation (GO:0045628)3.24800848
84detection of bacterium (GO:0016045)3.23957824
85regulation of tolerance induction (GO:0002643)3.23849918
86deoxyribonucleotide biosynthetic process (GO:0009263)3.23505297
87response to host immune response (GO:0052572)3.21067345
88response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.21067345
89CENP-A containing nucleosome assembly (GO:0034080)3.20936622
90negative regulation of type 2 immune response (GO:0002829)3.19875302
91myeloid leukocyte mediated immunity (GO:0002444)3.19397341
92deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.18046968
93regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.17014989
94ribosomal small subunit assembly (GO:0000028)3.16003309
95defense response to protozoan (GO:0042832)3.15357002
96negative regulation of DNA-dependent DNA replication (GO:2000104)3.15007613
97transcription elongation from RNA polymerase III promoter (GO:0006385)3.14685794
98termination of RNA polymerase III transcription (GO:0006386)3.14685794
99ribosome assembly (GO:0042255)3.14655504
100response to interferon-alpha (GO:0035455)3.14051077
101positive regulation of interferon-alpha production (GO:0032727)3.10694165
102regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.08754549
103regulation of natural killer cell mediated immunity (GO:0002715)3.08754549
104negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.07374403
105chromatin remodeling at centromere (GO:0031055)3.06264641
106maturation of SSU-rRNA (GO:0030490)3.05099246
107interferon-gamma-mediated signaling pathway (GO:0060333)3.03858232
108B cell mediated immunity (GO:0019724)3.01006248
109positive regulation of mast cell activation (GO:0033005)3.00997964
110response to muramyl dipeptide (GO:0032495)3.00743598
111activated T cell proliferation (GO:0050798)3.00060703
112negative regulation of interleukin-6 production (GO:0032715)2.99993333
113negative regulation of alpha-beta T cell activation (GO:0046636)2.99267367
114nucleobase-containing small molecule interconversion (GO:0015949)2.98714577
115regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.97968289
116telomere maintenance via recombination (GO:0000722)2.97545202
117regulation of regulatory T cell differentiation (GO:0045589)2.97343403
118deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.96440017
119lipopolysaccharide-mediated signaling pathway (GO:0031663)2.96231641
120positive regulation of B cell differentiation (GO:0045579)2.95848458
121negative regulation of innate immune response (GO:0045824)2.95826695
122regulation of regulated secretory pathway (GO:1903305)2.95161813
123DNA replication initiation (GO:0006270)2.94914253
124negative regulation of immunoglobulin mediated immune response (GO:0002890)2.92125180
125negative regulation of B cell mediated immunity (GO:0002713)2.92125180
126DNA-dependent DNA replication (GO:0006261)2.90881137
127negative thymic T cell selection (GO:0045060)2.90776495
128DNA synthesis involved in DNA repair (GO:0000731)2.89109399
129centriole assembly (GO:0098534)2.86190343
130response to fungus (GO:0009620)2.85476934
131DNA strand elongation involved in DNA replication (GO:0006271)2.83952869
132terpenoid biosynthetic process (GO:0016114)2.83698170
133regulation of leukocyte degranulation (GO:0043300)2.81136624
134DNA strand elongation (GO:0022616)2.80063294
135production of molecular mediator involved in inflammatory response (GO:0002532)2.79818186
136telomere maintenance via telomere lengthening (GO:0010833)2.77174731
137DNA integration (GO:0015074)2.76972096
138diterpenoid biosynthetic process (GO:0016102)2.75384629
139ribonucleoprotein complex biogenesis (GO:0022613)2.73944402
140rRNA methylation (GO:0031167)2.72722268
1417-methylguanosine mRNA capping (GO:0006370)2.71690208
142* neutrophil activation (GO:0042119)2.70254352
1437-methylguanosine RNA capping (GO:0009452)2.69631637
144RNA capping (GO:0036260)2.69631637
145response to host (GO:0075136)2.69180697
146response to host defenses (GO:0052200)2.69180697
147response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.69180697
148mitochondrial DNA replication (GO:0006264)2.68486285
149maturation of 5.8S rRNA (GO:0000460)2.68163831
150regulation of B cell receptor signaling pathway (GO:0050855)2.67576976
151macrophage differentiation (GO:0030225)2.65976940
152termination of RNA polymerase I transcription (GO:0006363)2.65886768
153germinal center formation (GO:0002467)2.65719117
154RNA destabilization (GO:0050779)2.65230435
155regulation of helicase activity (GO:0051095)2.64334337
156transcription from RNA polymerase I promoter (GO:0006360)2.64218238
157regulation of double-strand break repair via homologous recombination (GO:0010569)2.62950736
158mitotic recombination (GO:0006312)2.62100137
159meiotic chromosome segregation (GO:0045132)2.60759760
160centriole replication (GO:0007099)2.59608644
161positive regulation of mast cell degranulation (GO:0043306)2.55514260
162positive regulation of mast cell activation involved in immune response (GO:0033008)2.55514260
163superoxide metabolic process (GO:0006801)2.52044284
164tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.51273457
165RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.51273457
166establishment of integrated proviral latency (GO:0075713)2.50657838
167chronic inflammatory response (GO:0002544)2.49443859
168exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.48934688
169RNA methylation (GO:0001510)2.48443874
170intra-S DNA damage checkpoint (GO:0031573)2.48380152
171negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.47852625
172rRNA processing (GO:0006364)2.47729772
173hydrogen peroxide biosynthetic process (GO:0050665)2.46601195
174protein K6-linked ubiquitination (GO:0085020)2.46419236
175microtubule depolymerization (GO:0007019)2.46408150

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.89797487
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.41175691
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.01115175
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.78371855
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.58375270
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.54245870
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.17882804
8ELF1_17652178_ChIP-ChIP_JURKAT_Human3.05466280
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.89918929
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.85677968
11RUNX_20019798_ChIP-Seq_JUKART_Human2.84374221
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.84160986
13SPI1_23127762_ChIP-Seq_K562_Human2.76360880
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.75955707
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.74567356
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.72488322
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.64402000
18FOXM1_23109430_ChIP-Seq_U2OS_Human2.63407670
19MYC_18555785_ChIP-Seq_MESCs_Mouse2.62540748
20VDR_24763502_ChIP-Seq_THP-1_Human2.60346802
21VDR_21846776_ChIP-Seq_THP-1_Human2.56023975
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.49448852
23KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.45691119
24KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.45691119
25KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.45691119
26JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.44150837
27MAF_26560356_Chip-Seq_TH1_Human2.41160346
28MYB_26560356_Chip-Seq_TH2_Human2.34730803
29FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.31879860
30RUNX1_22412390_ChIP-Seq_EML_Mouse2.26684975
31E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.23605079
32* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.17062292
33UTX_26944678_Chip-Seq_JUKART_Human2.15985195
34NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.15909721
35NOTCH1_21737748_ChIP-Seq_TLL_Human2.14692814
36HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.11644141
37VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.09178390
38ETS1_20019798_ChIP-Seq_JURKAT_Human2.08622781
39SCL_19346495_ChIP-Seq_HPC-7_Human2.08583052
40* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.08238426
41PCGF2_27294783_Chip-Seq_ESCs_Mouse2.03392481
42SMAD_19615063_ChIP-ChIP_OVARY_Human2.02908982
43TP63_19390658_ChIP-ChIP_HaCaT_Human2.01209565
44* MYB_26560356_Chip-Seq_TH1_Human2.00647327
45RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.99091379
46BP1_19119308_ChIP-ChIP_Hs578T_Human1.98763064
47MYC_19079543_ChIP-ChIP_MESCs_Mouse1.96872334
48NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.93880551
49SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.91717808
50TCF7_22412390_ChIP-Seq_EML_Mouse1.91208615
51MYC_18358816_ChIP-ChIP_MESCs_Mouse1.90463211
52MYC_22102868_ChIP-Seq_BL_Human1.90334307
53VDR_23849224_ChIP-Seq_CD4+_Human1.90242188
54KDM2B_26808549_Chip-Seq_SUP-B15_Human1.89228165
55SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.88865836
56* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.88741966
57MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.88646798
58ELK1_19687146_ChIP-ChIP_HELA_Human1.83751476
59MYC_19030024_ChIP-ChIP_MESCs_Mouse1.83373243
60Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.82783172
61FLI1_27457419_Chip-Seq_LIVER_Mouse1.82725998
62NANOG_18555785_ChIP-Seq_MESCs_Mouse1.79084156
63GATA3_27048872_Chip-Seq_THYMUS_Human1.77429871
64MAF_26560356_Chip-Seq_TH2_Human1.76778622
65VDR_24787735_ChIP-Seq_THP-1_Human1.76117105
66EGR1_19374776_ChIP-ChIP_THP-1_Human1.74670895
67SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.71285703
68* SPI1_23547873_ChIP-Seq_NB4_Human1.70543158
69* NFE2_27457419_Chip-Seq_LIVER_Mouse1.66423965
70KDM2B_26808549_Chip-Seq_DND41_Human1.66044410
71* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.64860728
72CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.62619983
73MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.62509971
74CREB1_15753290_ChIP-ChIP_HEK293T_Human1.62431882
75FOXP3_21729870_ChIP-Seq_TREG_Human1.61598989
76CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.61017578
77* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.57574392
78MYB_21317192_ChIP-Seq_ERMYB_Mouse1.54615887
79GATA1_19941827_ChIP-Seq_MEL_Mouse1.54007759
80* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.53488655
81TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52714212
82VDR_22108803_ChIP-Seq_LS180_Human1.51603269
83KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.51032546
84HOXB4_20404135_ChIP-ChIP_EML_Mouse1.49850533
85NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.49762190
86THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.49555116
87YY1_21170310_ChIP-Seq_MESCs_Mouse1.48926103
88TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.47743876
89SRF_21415370_ChIP-Seq_HL-1_Mouse1.45683700
90KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.45429238
91HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.44370339
92SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.42272564
93MYC_18940864_ChIP-ChIP_HL60_Human1.42112374
94GATA3_26560356_Chip-Seq_TH2_Human1.41677788
95POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.40641232
96HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.40439982
97CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.39087320
98STAT6_21828071_ChIP-Seq_BEAS2B_Human1.38106395
99PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.36263292
100* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.34805204
101* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.33584523
102STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.31074873
103GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30180992
104NELFA_20434984_ChIP-Seq_ESCs_Mouse1.28982076
105PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.28456027
106EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.27792745
107CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.27098800
108* PU_27001747_Chip-Seq_BMDM_Mouse1.26543170
109PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24892991
110* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.24595948
111FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.23533496
112GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22172160
113E2F1_21310950_ChIP-Seq_MCF-7_Human1.21615683
114IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.21485656
115E2F1_18555785_ChIP-Seq_MESCs_Mouse1.21417588
116KAP1_22055183_ChIP-Seq_ESCs_Mouse1.21400722
117GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19534238
118CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19362150
119SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19167754
120IKZF1_21737484_ChIP-ChIP_HCT116_Human1.18871876
121GATA1_22383799_ChIP-Seq_G1ME_Mouse1.18805198
122VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.18495017
123POU5F1_16153702_ChIP-ChIP_HESCs_Human1.18104665
124MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.17348965
125IRF8_27001747_Chip-Seq_BMDM_Mouse1.16932347
126BMI1_23680149_ChIP-Seq_NPCS_Mouse1.16923109
127KDM2B_26808549_Chip-Seq_JURKAT_Human1.16855043
128ELK3_25401928_ChIP-Seq_HUVEC_Human1.16768276
129ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.15877934
130TTF2_22483619_ChIP-Seq_HELA_Human1.14124414
131* EZH2_27294783_Chip-Seq_NPCs_Mouse1.13195717
132GATA2_21666600_ChIP-Seq_HMVEC_Human1.12785505
133IGF1R_20145208_ChIP-Seq_DFB_Human1.12486028
134PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11694265
135RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.11248551
136STAT3_18555785_Chip-Seq_ESCs_Mouse1.10897206
137SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10412188
138GATA1_22025678_ChIP-Seq_K562_Human1.09106442
139PU.1_20513432_ChIP-Seq_Bcells_Mouse1.08495067
140RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.08272545
141YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07939544
142IRF1_19129219_ChIP-ChIP_H3396_Human1.06825468
143LXR_22292898_ChIP-Seq_THP-1_Human1.02946672
144LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.02821487
145* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.02610743
146ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.01952567
147* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.01787876
148BCL6_27268052_Chip-Seq_Bcells_Human1.01782828
149XRN2_22483619_ChIP-Seq_HELA_Human1.01777199
150* NMYC_18555785_Chip-Seq_ESCs_Mouse1.00063163
151GATA1_19941826_ChIP-Seq_K562_Human0.99767530
152* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.99486329
153GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99320387
154MYCN_18555785_ChIP-Seq_MESCs_Mouse0.99015738
155TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.98863295
156* ZFX_18555785_Chip-Seq_ESCs_Mouse0.97376774
157* E2F1_18555785_Chip-Seq_ESCs_Mouse0.96272973
158* P300_18555785_Chip-Seq_ESCs_Mouse0.94067235
159BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.93733226
160* SMAD1_18555785_Chip-Seq_ESCs_Mouse0.93666881
161* KLF4_18555785_Chip-Seq_ESCs_Mouse0.93128644
162STAT4_19710469_ChIP-ChIP_TH1__Mouse0.92495961
163* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.92204550
164NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.92148277
165DCP1A_22483619_ChIP-Seq_HELA_Human0.91876221
166BCOR_27268052_Chip-Seq_Bcells_Human0.91872886
167* OCT4_18555785_Chip-Seq_ESCs_Mouse0.91364755
168SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.90452167
169* RUNX1_27457419_Chip-Seq_LIVER_Mouse0.90225316
170RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89851016
171ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.88215060
172SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.87674285
173GATA2_19941826_ChIP-Seq_K562_Human0.87356052
174TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83520989
175SPI1_20517297_ChIP-Seq_HL60_Human0.83078200
176CTCF_27219007_Chip-Seq_ERYTHROID_Human0.82146985
177NCOR1_26117541_ChIP-Seq_K562_Human0.80700933
178STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.80440028
179NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.77356197
180GATA1_19941827_ChIP-Seq_MEL86_Mouse0.77103808

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.34694337
2MP0008058_abnormal_DNA_repair2.99757584
3MP0003136_yellow_coat_color2.89394150
4MP0001188_hyperpigmentation2.87617013
5MP0000685_abnormal_immune_system2.87036762
6MP0000566_synostosis2.86663315
7MP0006292_abnormal_olfactory_placode2.73138816
8MP0003191_abnormal_cellular_cholesterol2.71234143
9MP0001853_heart_inflammation2.71075181
10MP0002132_abnormal_respiratory_system2.60584567
11MP0003111_abnormal_nucleus_morphology2.58347165
12MP0009785_altered_susceptibility_to2.57371841
13MP0006082_CNS_inflammation2.56144558
14MP0008057_abnormal_DNA_replication2.52690898
15MP0004381_abnormal_hair_follicle2.51484860
16MP0003300_gastrointestinal_ulcer2.37088563
17MP0010094_abnormal_chromosome_stability2.33998890
18MP0009278_abnormal_bone_marrow2.27929405
19MP0003941_abnormal_skin_development2.24102810
20MP0005174_abnormal_tail_pigmentation2.21272712
21MP0002396_abnormal_hematopoietic_system2.16982686
22* MP0003436_decreased_susceptibility_to2.13223922
23* MP0002419_abnormal_innate_immunity2.10371746
24MP0003763_abnormal_thymus_physiology2.07910347
25MP0005409_darkened_coat_color2.06484219
26MP0003724_increased_susceptibility_to2.04488273
27MP0001986_abnormal_taste_sensitivity2.03607559
28MP0002102_abnormal_ear_morphology2.01563872
29MP0000015_abnormal_ear_pigmentation1.96441766
30MP0003077_abnormal_cell_cycle1.89455006
31MP0002148_abnormal_hypersensitivity_rea1.87017258
32MP0010155_abnormal_intestine_physiology1.78791973
33MP0003866_abnormal_defecation1.78342944
34MP0008260_abnormal_autophagy1.77232645
35* MP0002277_abnormal_respiratory_mucosa1.68549734
36MP0004947_skin_inflammation1.57305617
37* MP0005025_abnormal_response_to1.56110911
38MP0003172_abnormal_lysosome_physiology1.51399833
39MP0000343_altered_response_to1.48838520
40MP0009333_abnormal_splenocyte_physiolog1.48592852
41MP0001835_abnormal_antigen_presentation1.48427074
42MP0008932_abnormal_embryonic_tissue1.47393933
43MP0004808_abnormal_hematopoietic_stem1.46122690
44* MP0000703_abnormal_thymus_morphology1.44411054
45* MP0008469_abnormal_protein_level1.43502212
46MP0002837_dystrophic_cardiac_calcinosis1.41386635
47MP0002095_abnormal_skin_pigmentation1.36906606
48* MP0002452_abnormal_antigen_presenting1.35948950
49MP0006072_abnormal_retinal_apoptosis1.33377708
50* MP0005000_abnormal_immune_tolerance1.32933158
51MP0003828_pulmonary_edema1.32838482
52* MP0001819_abnormal_immune_cell1.32241199
53MP0003786_premature_aging1.32106739
54* MP0002420_abnormal_adaptive_immunity1.30476412
55MP0001851_eye_inflammation1.29916012
56MP0001186_pigmentation_phenotype1.29116639
57MP0003075_altered_response_to1.26502037
58MP0005397_hematopoietic_system_phenotyp1.26001950
59MP0001545_abnormal_hematopoietic_system1.26001950
60MP0005310_abnormal_salivary_gland1.25984191
61MP0004957_abnormal_blastocyst_morpholog1.23052227
62MP0008877_abnormal_DNA_methylation1.23014543
63MP0002160_abnormal_reproductive_system1.21590006
64MP0002405_respiratory_system_inflammati1.19963620
65MP0005171_absent_coat_pigmentation1.19611027
66MP0004883_abnormal_blood_vessel1.19593219
67* MP0002723_abnormal_immune_serum1.19082671
68* MP0009764_decreased_sensitivity_to1.16861651
69MP0005670_abnormal_white_adipose1.16711962
70* MP0001800_abnormal_humoral_immune1.15991574
71MP0003690_abnormal_glial_cell1.15021325
72MP0000490_abnormal_crypts_of1.11609537
73* MP0000858_altered_metastatic_potential1.10812627
74MP0003718_maternal_effect1.10245034
75MP0008007_abnormal_cellular_replicative1.09840614
76MP0005075_abnormal_melanosome_morpholog1.09761766
77MP0002998_abnormal_bone_remodeling1.09137407
78MP0004510_myositis1.07142152
79MP0000371_diluted_coat_color1.06421982
80MP0003303_peritoneal_inflammation1.01793219
81MP0002398_abnormal_bone_marrow1.00184680
82MP0005408_hypopigmentation0.99586001
83MP0009379_abnormal_foot_pigmentation0.99286112
84MP0002098_abnormal_vibrissa_morphology0.98910952
85MP0005389_reproductive_system_phenotype0.98025454
86MP0005166_decreased_susceptibility_to0.97187453
87MP0002933_joint_inflammation0.96611374
88MP0001790_abnormal_immune_system0.96527129
89MP0005387_immune_system_phenotype0.96527129
90* MP0000716_abnormal_immune_system0.96489604
91MP0001845_abnormal_inflammatory_respons0.93345439
92MP0005671_abnormal_response_to0.92645072
93MP0003186_abnormal_redox_activity0.92388042
94MP0000678_abnormal_parathyroid_gland0.92123303
95MP0003045_fibrosis0.92032851
96MP0000579_abnormal_nail_morphology0.91615489
97MP0008789_abnormal_olfactory_epithelium0.90457710
98* MP0003448_altered_tumor_morphology0.90403629
99MP0005464_abnormal_platelet_physiology0.88452126
100MP0002166_altered_tumor_susceptibility0.87744079
101MP0002075_abnormal_coat/hair_pigmentati0.87610438
102MP0003279_aneurysm0.87407846
103MP0000569_abnormal_digit_pigmentation0.85921224
104MP0001919_abnormal_reproductive_system0.85239427
105MP0001663_abnormal_digestive_system0.84502466
106MP0009763_increased_sensitivity_to0.84017969
107* MP0002429_abnormal_blood_cell0.83320272
108MP0004130_abnormal_muscle_cell0.83091072
109MP0000372_irregular_coat_pigmentation0.82350778
110MP0004133_heterotaxia0.82133333
111MP0003315_abnormal_perineum_morphology0.81971893
112* MP0001533_abnormal_skeleton_physiology0.81597593
113* MP0005390_skeleton_phenotype0.81480938
114MP0003878_abnormal_ear_physiology0.79689983
115MP0005377_hearing/vestibular/ear_phenot0.79689983
116MP0001764_abnormal_homeostasis0.79337889
117* MP0000689_abnormal_spleen_morphology0.78744363
118MP0008004_abnormal_stomach_pH0.78309566
119* MP0002722_abnormal_immune_system0.77858654
120MP0000613_abnormal_salivary_gland0.76404888
121MP0000465_gastrointestinal_hemorrhage0.75913250
122MP0003950_abnormal_plasma_membrane0.74243309
123MP0000313_abnormal_cell_death0.74192913
124MP0004858_abnormal_nervous_system0.72556967
125MP0003221_abnormal_cardiomyocyte_apopto0.72311408
126MP0003183_abnormal_peptide_metabolism0.71293005
127MP0005164_abnormal_response_to0.70760283
128MP0000681_abnormal_thyroid_gland0.69836118
129MP0002928_abnormal_bile_duct0.68949586
130MP0008874_decreased_physiological_sensi0.68877747
131MP0005451_abnormal_body_composition0.68773925
132MP0002019_abnormal_tumor_incidence0.68442797
133MP0009765_abnormal_xenobiotic_induced0.66902340
134MP0005248_abnormal_Harderian_gland0.64670859
135MP0000604_amyloidosis0.62294331
136MP0001873_stomach_inflammation0.62023624
137MP0002133_abnormal_respiratory_system0.60171501
138MP0005388_respiratory_system_phenotype0.60171501
139MP0000249_abnormal_blood_vessel0.58961489
140MP0004484_altered_response_of0.58846851
141MP0003252_abnormal_bile_duct0.58396769
142MP0005319_abnormal_enzyme/_coenzyme0.56302281
143* MP0003795_abnormal_bone_structure0.54554393
144MP0003806_abnormal_nucleotide_metabolis0.53990274
145MP0003656_abnormal_erythrocyte_physiolo0.53941782
146MP0005083_abnormal_biliary_tract0.53694566
147MP0002653_abnormal_ependyma_morphology0.53662631
148MP0002332_abnormal_exercise_endurance0.53152590

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.98268876
2Chromsome breakage (HP:0040012)5.55508912
3Elevated erythrocyte sedimentation rate (HP:0003565)4.96523347
4Recurrent abscess formation (HP:0002722)4.82544351
5Gastrointestinal infarctions (HP:0005244)4.78055488
6Hypochromic microcytic anemia (HP:0004840)4.75371097
7Keratoconjunctivitis sicca (HP:0001097)4.44296242
8Eczematoid dermatitis (HP:0000976)4.41836054
9Abnormal delayed hypersensitivity skin test (HP:0002963)4.16921696
10Encephalitis (HP:0002383)4.12914304
11Keratoconjunctivitis (HP:0001096)4.12668417
12Spontaneous hematomas (HP:0007420)3.99910168
13Duplicated collecting system (HP:0000081)3.87721749
14Hypochromic anemia (HP:0001931)3.87172375
15Increased IgE level (HP:0003212)3.81765012
16Recurrent bacterial skin infections (HP:0005406)3.81759412
17Reticulocytopenia (HP:0001896)3.76548362
18Chronic obstructive pulmonary disease (HP:0006510)3.67396876
19Obstructive lung disease (HP:0006536)3.67396876
20Vasculitis (HP:0002633)3.61762154
21Peritonitis (HP:0002586)3.61759418
22Abnormality of macrophages (HP:0004311)3.59004909
23Abnormality of the renal collecting system (HP:0004742)3.50411223
24Chest pain (HP:0100749)3.47581784
25Recurrent gram-negative bacterial infections (HP:0005420)3.45516837
26Meckel diverticulum (HP:0002245)3.40644458
27Episodic fever (HP:0001954)3.37471193
28Gingivitis (HP:0000230)3.28924488
29Hemoptysis (HP:0002105)3.21583862
30Breast hypoplasia (HP:0003187)3.21518708
31Mediastinal lymphadenopathy (HP:0100721)3.19226005
32Abnormality of the ileum (HP:0001549)3.17542182
33T lymphocytopenia (HP:0005403)3.14856529
34Birth length less than 3rd percentile (HP:0003561)3.13675753
35Anorexia (HP:0002039)3.09777552
36Abnormality of the preputium (HP:0100587)3.07765053
37Arterial thrombosis (HP:0004420)3.07613121
38Abnormality of T cell number (HP:0011839)3.07593906
39Gingival bleeding (HP:0000225)3.06147303
40Pulmonary infiltrates (HP:0002113)3.02928809
41Aplasia/Hypoplasia of the uvula (HP:0010293)2.99644896
42Pulmonary embolism (HP:0002204)2.97747018
43Granulocytopenia (HP:0001913)2.88220248
44Microcytic anemia (HP:0001935)2.83025614
45Abnormality of chromosome stability (HP:0003220)2.70660917
46Clubbing of toes (HP:0100760)2.70657908
47Increased IgM level (HP:0003496)2.68430001
48Abnormality of T cells (HP:0002843)2.68132205
49Progressive external ophthalmoplegia (HP:0000590)2.67123630
50Amyloidosis (HP:0011034)2.66094245
51Cheilitis (HP:0100825)2.64306928
52Epistaxis (HP:0000421)2.64259043
53Inflammation of the large intestine (HP:0002037)2.61678103
54Septo-optic dysplasia (HP:0100842)2.59702778
55Abnormality of the peritoneum (HP:0002585)2.56263968
56Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.55325646
57Myelodysplasia (HP:0002863)2.55139688
58Abnormality of the pleura (HP:0002103)2.54564895
59Bone marrow hypocellularity (HP:0005528)2.52226705
60Gangrene (HP:0100758)2.51813587
61Osteomyelitis (HP:0002754)2.51653766
62Gastrointestinal inflammation (HP:0004386)2.51640334
63Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.50512312
64Type I transferrin isoform profile (HP:0003642)2.50009907
65Absent radius (HP:0003974)2.48354402
66Sepsis (HP:0100806)2.47672102
67Stomatitis (HP:0010280)2.47015299
68Absent thumb (HP:0009777)2.46455576
69Ectopic kidney (HP:0000086)2.43823597
70Pustule (HP:0200039)2.42139995
71Absent forearm bone (HP:0003953)2.36001876
72Aplasia involving forearm bones (HP:0009822)2.36001876
73Recurrent fungal infections (HP:0002841)2.35983009
74Petechiae (HP:0000967)2.35733266
75Recurrent viral infections (HP:0004429)2.35596030
76Panhypogammaglobulinemia (HP:0003139)2.34342007
77Abnormality of the endocardium (HP:0004306)2.33307986
78Triphalangeal thumb (HP:0001199)2.31206163
79Tracheoesophageal fistula (HP:0002575)2.30937647
80Recurrent skin infections (HP:0001581)2.28117102
81Keratitis (HP:0000491)2.27003418
82Meningitis (HP:0001287)2.26743588
83Abnormality of T cell physiology (HP:0011840)2.25707437
84Upper limb muscle weakness (HP:0003484)2.24804045
85Glomerulopathy (HP:0100820)2.24663279
86Retrobulbar optic neuritis (HP:0100654)2.24565930
87Optic neuritis (HP:0100653)2.24565930
88Prostate neoplasm (HP:0100787)2.24508137
89Recurrent pneumonia (HP:0006532)2.23333743
90Lymphopenia (HP:0001888)2.23022632
91Hypergammaglobulinemia (HP:0010702)2.21766543
92Microvesicular hepatic steatosis (HP:0001414)2.19985461
93Abnormality of the pericardium (HP:0001697)2.19719888
94Eosinophilia (HP:0001880)2.19266736
95Abnormality of DNA repair (HP:0003254)2.18589311
96Hepatosplenomegaly (HP:0001433)2.18215733
97Toxemia of pregnancy (HP:0100603)2.17906947
98Acne (HP:0001061)2.15657561
99Acute hepatic failure (HP:0006554)2.15517841
100Myositis (HP:0100614)2.13977954
101Subacute progressive viral hepatitis (HP:0006572)2.13615537
102Aplastic anemia (HP:0001915)2.13076864
103Abnormality of cells of the lymphoid lineage (HP:0012140)2.12133136
104Skin ulcer (HP:0200042)2.10533908
105Vertigo (HP:0002321)2.09846541
106Reduced antithrombin III activity (HP:0001976)2.07222746
107Slow saccadic eye movements (HP:0000514)2.06110067
108Abnormal platelet volume (HP:0011876)2.05659786
109Metaphyseal cupping (HP:0003021)2.05534525
110Osteomalacia (HP:0002749)2.05388461
111Chronic otitis media (HP:0000389)2.04384346
112Duodenal stenosis (HP:0100867)2.04221119
113Small intestinal stenosis (HP:0012848)2.04221119
114Aplasia/Hypoplasia of the earlobes (HP:0009906)2.02786774
115Abnormality of the carotid arteries (HP:0005344)2.02745184
116Orchitis (HP:0100796)2.01785779
117Abnormality of the heme biosynthetic pathway (HP:0010472)2.00533550
118Premature loss of primary teeth (HP:0006323)1.99357494
119Parakeratosis (HP:0001036)1.97845633
120Urticaria (HP:0001025)1.96479191
121Pallor (HP:0000980)1.96074533
122Chronic mucocutaneous candidiasis (HP:0002728)1.93960065
123Recurrent cutaneous fungal infections (HP:0011370)1.93960065
124Segmental peripheral demyelination/remyelination (HP:0003481)1.93438142
125Viral hepatitis (HP:0006562)1.92761931
126Aplasia/Hypoplasia of the sacrum (HP:0008517)1.92090246
127Short thumb (HP:0009778)1.91828177
128Stomach cancer (HP:0012126)1.91127959
129Abnormality of the septum pellucidum (HP:0007375)1.90831307
130IgM deficiency (HP:0002850)1.90626363
131Difficulty running (HP:0009046)1.90214382
132Patellar aplasia (HP:0006443)1.87045876
133Agnosia (HP:0010524)1.87006929
134Prolonged bleeding time (HP:0003010)1.86978521
135Duplication of thumb phalanx (HP:0009942)1.85929898
136Hypermelanotic macule (HP:0001034)1.85908976
137Polycythemia (HP:0001901)1.85675899
138Metaphyseal irregularity (HP:0003025)1.85325884
139Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.83402392
140Purpura (HP:0000979)1.82158591
141Supernumerary spleens (HP:0009799)1.81949955
142Skin rash (HP:0000988)1.81521153
143Sex reversal (HP:0012245)1.80354055
144Abnormal sex determination (HP:0012244)1.80354055
145Thrombophlebitis (HP:0004418)1.79930808
146Abnormality of eosinophils (HP:0001879)1.79706432
147Polyneuropathy (HP:0001271)1.79530586
148Absent septum pellucidum (HP:0001331)1.78903735
149Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.77935297
150Recurrent bronchitis (HP:0002837)1.77089512
151Papilledema (HP:0001085)1.77046951
152Macrocytic anemia (HP:0001972)1.75828989
153Conical tooth (HP:0000698)1.75477512
154Cleft eyelid (HP:0000625)1.75244963
155Carpal bone hypoplasia (HP:0001498)1.73830670
156Aplasia/Hypoplasia of the patella (HP:0006498)1.73377854
157Recurrent lower respiratory tract infections (HP:0002783)1.72061926
158Cellulitis (HP:0100658)1.69382493
159Optic nerve hypoplasia (HP:0000609)1.69107708
160Abnormal lung lobation (HP:0002101)1.69102410
161Short femoral neck (HP:0100864)1.68714781
162Aplasia/hypoplasia of the uterus (HP:0008684)1.68476084
163Leukocytosis (HP:0001974)1.67280672
164Aplasia/Hypoplasia of the breasts (HP:0010311)1.65931324
165Horseshoe kidney (HP:0000085)1.65246197
166Distal lower limb muscle weakness (HP:0009053)1.64752534
167Abnormality of cells of the erythroid lineage (HP:0012130)1.64122688
168Abnormal number of erythroid precursors (HP:0012131)1.63890297
169Congenital stationary night blindness (HP:0007642)1.63450345
170Abnormality of the duodenum (HP:0002246)1.63404867
171Premature graying of hair (HP:0002216)1.62807103

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK195.33680933
2IRAK35.04450958
3IRAK44.61230533
4PLK44.15375748
5ZAK3.06267024
6ERN13.01852474
7STK163.01365166
8BUB12.94826700
9TYK22.85236385
10IRAK12.38476296
11GRK62.27265764
12TLK12.21624220
13SRPK12.04438169
14ZAP702.04057978
15TAOK11.99585850
16EIF2AK21.94144226
17TEC1.92680744
18BLK1.91799315
19MAP3K31.89771288
20IRAK21.77390781
21JAK31.72149664
22CLK11.66174353
23MAP3K111.64258457
24KSR21.60780958
25JAK21.58647784
26TXK1.48960382
27GRK11.47866840
28EIF2AK31.45120932
29VRK11.44403818
30STK41.42954396
31CASK1.38750107
32MAP3K11.34764256
33IKBKE1.30864219
34WEE11.29555863
35MAP2K31.26333376
36TAOK31.25687960
37JAK11.24604571
38ERBB31.21100065
39PTK61.18608281
40MARK11.15776255
41BTK1.15729601
42MKNK21.15371026
43EIF2AK11.15027533
44CDC71.13514595
45LCK1.13323186
46MAP3K121.13288242
47AKT31.09559423
48EPHA21.08473150
49MARK21.06632795
50TRPM71.05257668
51YES11.03308126
52TBK11.03245776
53TTK1.02722527
54MAP3K21.01095343
55ADRBK21.00911793
56PRKD21.00325307
57MKNK11.00300175
58MAP3K60.99355035
59CSF1R0.98151081
60NEK60.97205809
61MAP3K130.95742003
62PLK10.95685135
63MATK0.95407019
64CDK70.94819922
65TNIK0.90608470
66MAP2K40.90535496
67KIT0.90316332
68ATR0.87557970
69EPHA30.87422319
70PDK10.85187642
71PLK30.84450243
72SIK20.84040104
73PBK0.83823158
74PTK2B0.83382395
75CSK0.83328005
76LRRK20.82572428
77DYRK30.82445233
78PDPK10.80140554
79TRIB30.79398435
80PAK40.78279542
81SMG10.75687569
82FES0.75149513
83STK110.75129520
84STK100.74321223
85FYN0.72667355
86KDR0.72292123
87DYRK1B0.70699489
88GRK70.70339141
89TESK20.69946722
90TAOK20.69908120
91BMPR1B0.69771744
92MAP3K70.69633023
93STK380.69575360
94IKBKB0.68889150
95FGR0.68547128
96CHEK20.67524176
97MAP3K140.66873924
98EPHB10.66795157
99MAP2K60.66275894
100HCK0.64539889
101RAF10.64041823
102FGFR30.63496203
103MAP3K50.62341704
104KSR10.61264858
105TGFBR20.61153158
106FGFR40.59973401
107DYRK20.59939842
108ACVR1B0.58520665
109SGK30.56456900
110PIM10.56227010
111BMPR20.55880661
112STK38L0.54755637
113LYN0.54636926
114RET0.54544884
115RIPK40.54379704
116PRKCQ0.54250723
117MAPK120.54213002
118DAPK20.52725457
119AURKA0.50145056
120RPS6KA50.49941152
121PIK3CG0.48553382
122HIPK20.47626653
123AURKB0.47601353
124PRKCZ0.45920462
125PRKG20.44817219
126WNK10.42607385
127BRSK20.42495209
128NLK0.41702359
129SIK30.41403619
130SGK20.40549237
131CDC42BPA0.39818058
132MARK30.39577440
133RPS6KA40.39122550
134MAPKAPK20.39007965
135ALK0.38639311
136MAPK70.38613516
137SIK10.37649733
138RPS6KL10.37332719
139RPS6KC10.37332719
140PRPF4B0.37199354
141PRKCI0.37098591
142PRKCH0.36556527
143CAMKK10.36353405
144MAP3K100.35726980
145MAP4K10.35682608
146RIPK10.34490463
147CSNK2A10.34484297
148INSRR0.34295685
149ATM0.33303899
150NME20.32482708
151TSSK60.32388613
152PRKCD0.32216972
153NEK20.31024927
154TNK20.30033314
155BRD40.29999999
156MST40.29151109
157MAPK40.28466728
158RPS6KB20.26445297
159ITK0.25752951
160NME10.24491821
161SYK0.24158941
162MYLK0.24019092
163BRAF0.23946224
164MAP3K80.22959573
165CSNK2A20.22846000

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.34310785
2Ribosome_Homo sapiens_hsa030103.33793999
3Fanconi anemia pathway_Homo sapiens_hsa034603.09167290
4RNA polymerase_Homo sapiens_hsa030203.04778714
5Mismatch repair_Homo sapiens_hsa034303.00296619
6Homologous recombination_Homo sapiens_hsa034402.84505445
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.46862157
8Asthma_Homo sapiens_hsa053102.32757635
9Pyrimidine metabolism_Homo sapiens_hsa002402.28491176
10B cell receptor signaling pathway_Homo sapiens_hsa046622.25575307
11Proteasome_Homo sapiens_hsa030502.24304708
12Spliceosome_Homo sapiens_hsa030402.12206653
13Base excision repair_Homo sapiens_hsa034101.99596956
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.96800826
15Non-homologous end-joining_Homo sapiens_hsa034501.96361022
16Acute myeloid leukemia_Homo sapiens_hsa052211.84198865
17Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.81808393
18Nucleotide excision repair_Homo sapiens_hsa034201.80435818
19Basal transcription factors_Homo sapiens_hsa030221.76480760
20Leishmaniasis_Homo sapiens_hsa051401.67281346
21T cell receptor signaling pathway_Homo sapiens_hsa046601.66757647
22Type I diabetes mellitus_Homo sapiens_hsa049401.55386639
23Antigen processing and presentation_Homo sapiens_hsa046121.51265758
24Cell cycle_Homo sapiens_hsa041101.47818315
25Toxoplasmosis_Homo sapiens_hsa051451.46580701
26One carbon pool by folate_Homo sapiens_hsa006701.45540262
27Viral myocarditis_Homo sapiens_hsa054161.43275923
28Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.41577242
29p53 signaling pathway_Homo sapiens_hsa041151.41537575
30NF-kappa B signaling pathway_Homo sapiens_hsa040641.34851232
31Non-small cell lung cancer_Homo sapiens_hsa052231.34848204
32Hematopoietic cell lineage_Homo sapiens_hsa046401.34667275
33Purine metabolism_Homo sapiens_hsa002301.34471298
34Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.34010518
35RNA transport_Homo sapiens_hsa030131.34009790
36RNA degradation_Homo sapiens_hsa030181.31142003
37Arachidonic acid metabolism_Homo sapiens_hsa005901.28206105
38Platelet activation_Homo sapiens_hsa046111.17384321
39Staphylococcus aureus infection_Homo sapiens_hsa051501.17239296
40Hepatitis C_Homo sapiens_hsa051601.17052318
41Pancreatic cancer_Homo sapiens_hsa052121.07669690
42Intestinal immune network for IgA production_Homo sapiens_hsa046721.06120531
43NOD-like receptor signaling pathway_Homo sapiens_hsa046211.05136429
44Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.03549453
45VEGF signaling pathway_Homo sapiens_hsa043701.01609379
46Epstein-Barr virus infection_Homo sapiens_hsa051691.01060079
47Herpes simplex infection_Homo sapiens_hsa051681.00083616
48Chronic myeloid leukemia_Homo sapiens_hsa052200.99924123
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.98853454
50Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.97489154
51Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.97152303
52Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.96779076
53SNARE interactions in vesicular transport_Homo sapiens_hsa041300.96734132
54RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.95307468
55Renin-angiotensin system_Homo sapiens_hsa046140.95195196
56African trypanosomiasis_Homo sapiens_hsa051430.92814898
57Renal cell carcinoma_Homo sapiens_hsa052110.92035777
58Other glycan degradation_Homo sapiens_hsa005110.91797285
59Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.91184854
60Autoimmune thyroid disease_Homo sapiens_hsa053200.91154686
61Prolactin signaling pathway_Homo sapiens_hsa049170.90276564
62* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.89629421
63Graft-versus-host disease_Homo sapiens_hsa053320.89106012
64* Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.87347383
65Oxidative phosphorylation_Homo sapiens_hsa001900.86783779
66Allograft rejection_Homo sapiens_hsa053300.85948062
67Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.85605127
68* Endocytosis_Homo sapiens_hsa041440.83805508
69Sphingolipid metabolism_Homo sapiens_hsa006000.83330709
70Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.81324450
71Systemic lupus erythematosus_Homo sapiens_hsa053220.81189247
72Leukocyte transendothelial migration_Homo sapiens_hsa046700.80639175
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.80525203
74Huntingtons disease_Homo sapiens_hsa050160.80426410
75Measles_Homo sapiens_hsa051620.79404866
76FoxO signaling pathway_Homo sapiens_hsa040680.78319462
77Glutathione metabolism_Homo sapiens_hsa004800.77682343
78Pertussis_Homo sapiens_hsa051330.77211769
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.76696986
80Carbohydrate digestion and absorption_Homo sapiens_hsa049730.75997820
81Endometrial cancer_Homo sapiens_hsa052130.75755997
82Notch signaling pathway_Homo sapiens_hsa043300.74903757
83Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73194848
84Dorso-ventral axis formation_Homo sapiens_hsa043200.71906894
85Choline metabolism in cancer_Homo sapiens_hsa052310.70781059
86Rheumatoid arthritis_Homo sapiens_hsa053230.70573870
87Malaria_Homo sapiens_hsa051440.70360550
88Histidine metabolism_Homo sapiens_hsa003400.69881975
89AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.68942194
90Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67393493
91Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65827977
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.65611203
93Toll-like receptor signaling pathway_Homo sapiens_hsa046200.65602870
94* Phospholipase D signaling pathway_Homo sapiens_hsa040720.64704894
95Legionellosis_Homo sapiens_hsa051340.64704207
96Osteoclast differentiation_Homo sapiens_hsa043800.64672605
97Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64184298
98Phototransduction_Homo sapiens_hsa047440.63886188
99Primary immunodeficiency_Homo sapiens_hsa053400.63338902
100Phagosome_Homo sapiens_hsa041450.62539292
101Protein export_Homo sapiens_hsa030600.61789405
102Amoebiasis_Homo sapiens_hsa051460.61023489
103GnRH signaling pathway_Homo sapiens_hsa049120.60524819
104Parkinsons disease_Homo sapiens_hsa050120.60220975
105mRNA surveillance pathway_Homo sapiens_hsa030150.59682553
106Ether lipid metabolism_Homo sapiens_hsa005650.59617544
107beta-Alanine metabolism_Homo sapiens_hsa004100.59420688
108Colorectal cancer_Homo sapiens_hsa052100.59036032
109Linoleic acid metabolism_Homo sapiens_hsa005910.58907717
110Rap1 signaling pathway_Homo sapiens_hsa040150.57988570
111Retinol metabolism_Homo sapiens_hsa008300.57970766
112Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57331035
113mTOR signaling pathway_Homo sapiens_hsa041500.56993135
114Jak-STAT signaling pathway_Homo sapiens_hsa046300.56430844
115Tuberculosis_Homo sapiens_hsa051520.56174993
116Insulin resistance_Homo sapiens_hsa049310.55892272
117Inositol phosphate metabolism_Homo sapiens_hsa005620.55584083
118ErbB signaling pathway_Homo sapiens_hsa040120.55225304
119HIF-1 signaling pathway_Homo sapiens_hsa040660.55033204
120Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.54161716
121Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.52628335
122TNF signaling pathway_Homo sapiens_hsa046680.51621634
123Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.51234226
124Shigellosis_Homo sapiens_hsa051310.51031709
125Influenza A_Homo sapiens_hsa051640.50374713
126Glycerophospholipid metabolism_Homo sapiens_hsa005640.50265720
127MAPK signaling pathway_Homo sapiens_hsa040100.50133328
128Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49181419
129Type II diabetes mellitus_Homo sapiens_hsa049300.48677777
130Phenylalanine metabolism_Homo sapiens_hsa003600.48195178
131Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.46070330
132Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45026246
133Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.43682403
134Regulation of autophagy_Homo sapiens_hsa041400.42751264
135Mineral absorption_Homo sapiens_hsa049780.40215345
136alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.40138050
137Prostate cancer_Homo sapiens_hsa052150.39625452
138Estrogen signaling pathway_Homo sapiens_hsa049150.39018653
139Hepatitis B_Homo sapiens_hsa051610.38721858
140Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38676499
141Glioma_Homo sapiens_hsa052140.38383808
142* Chemokine signaling pathway_Homo sapiens_hsa040620.37510686
143Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.37451684
144Apoptosis_Homo sapiens_hsa042100.36480492
145Viral carcinogenesis_Homo sapiens_hsa052030.34698130
146HTLV-I infection_Homo sapiens_hsa051660.34238627
147Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30869447
148MicroRNAs in cancer_Homo sapiens_hsa052060.29955548
149Salmonella infection_Homo sapiens_hsa051320.28823015
150Alzheimers disease_Homo sapiens_hsa050100.28494123
151Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.27043564

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