CXCR4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.41993105
2regulation of gamma-delta T cell differentiation (GO:0045586)5.21907256
3B cell receptor signaling pathway (GO:0050853)5.17713970
4positive regulation of B cell differentiation (GO:0045579)4.99557683
5regulation of gamma-delta T cell activation (GO:0046643)4.90494181
6negative regulation of cell killing (GO:0031342)4.78440248
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.78440248
8regulation of B cell receptor signaling pathway (GO:0050855)4.74473709
9antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.54596192
10antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.54596192
11antigen processing and presentation of endogenous antigen (GO:0019883)4.52727490
12negative regulation of phagocytosis (GO:0050765)4.41805747
13negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.37704194
14regulation of B cell differentiation (GO:0045577)4.35722807
15positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.16937669
16antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.13969585
17leukocyte aggregation (GO:0070486)4.06914126
18positive regulation by symbiont of host defense response (GO:0052509)4.00984166
19modulation by symbiont of host defense response (GO:0052031)4.00984166
20modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.00984166
21modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.00984166
22positive regulation by organism of defense response of other organism involved in symbiotic interact4.00984166
23modulation by symbiont of host immune response (GO:0052553)4.00984166
24neutrophil activation involved in immune response (GO:0002283)3.96411548
25positive thymic T cell selection (GO:0045059)3.89944967
26tolerance induction (GO:0002507)3.88684097
27negative regulation of T cell mediated immunity (GO:0002710)3.84727272
28activated T cell proliferation (GO:0050798)3.84333317
29positive regulation of alpha-beta T cell proliferation (GO:0046641)3.74972872
30regulation of germinal center formation (GO:0002634)3.70022859
31negative regulation of lymphocyte mediated immunity (GO:0002707)3.67939465
32negative T cell selection (GO:0043383)3.64333684
33positive regulation of granulocyte differentiation (GO:0030854)3.61892022
34V(D)J recombination (GO:0033151)3.59737365
35regulation of interferon-beta biosynthetic process (GO:0045357)3.54813582
36regulation of T cell mediated cytotoxicity (GO:0001914)3.53819996
37regulation of regulatory T cell differentiation (GO:0045589)3.53621723
38negative thymic T cell selection (GO:0045060)3.50992381
39T cell selection (GO:0045058)3.47539041
40cellular response to zinc ion (GO:0071294)3.47445868
41CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.44280311
42T-helper cell differentiation (GO:0042093)3.44280311
43regulation of interleukin-12 biosynthetic process (GO:0045075)3.43465135
44cellular extravasation (GO:0045123)3.41671835
45positive regulation of T cell differentiation in thymus (GO:0033089)3.39611985
46regulation of tolerance induction (GO:0002643)3.37901565
47positive T cell selection (GO:0043368)3.33914730
48positive regulation of T cell mediated cytotoxicity (GO:0001916)3.31241341
49negative regulation of interleukin-1 beta production (GO:0032691)3.30418855
50NIK/NF-kappaB signaling (GO:0038061)3.30263859
51negative regulation of leukocyte mediated immunity (GO:0002704)3.30094463
52hepatocyte apoptotic process (GO:0097284)3.30081209
53macrophage activation involved in immune response (GO:0002281)3.27461428
54negative regulation of bone resorption (GO:0045779)3.27014133
55regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.26588928
56antigen receptor-mediated signaling pathway (GO:0050851)3.26546543
57T cell homeostasis (GO:0043029)3.24466593
58alpha-beta T cell differentiation (GO:0046632)3.23965940
59* neutrophil activation (GO:0042119)3.22311079
60thymic T cell selection (GO:0045061)3.20935663
61Arp2/3 complex-mediated actin nucleation (GO:0034314)3.17279304
62detection of other organism (GO:0098543)3.16134127
63negative regulation of innate immune response (GO:0045824)3.14316481
64detection of bacterium (GO:0016045)3.13948166
65response to muramyl dipeptide (GO:0032495)3.13899641
66negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.13375261
67regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.13144035
68positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.13144035
69lymphocyte homeostasis (GO:0002260)3.12984430
70mature B cell differentiation (GO:0002335)3.12342333
71RNA destabilization (GO:0050779)3.11237084
72immunoglobulin mediated immune response (GO:0016064)3.11213568
73myeloid dendritic cell activation (GO:0001773)3.09389271
74response to interleukin-15 (GO:0070672)3.07840945
75T cell differentiation (GO:0030217)3.06727494
76positive regulation of mast cell activation (GO:0033005)3.06109155
77positive regulation of histone deacetylation (GO:0031065)3.05849872
78B cell homeostasis (GO:0001782)3.05347111
79mucosal-associated lymphoid tissue development (GO:0048537)3.04900320
80Peyers patch development (GO:0048541)3.04900320
81respiratory burst (GO:0045730)3.04641078
82germinal center formation (GO:0002467)3.04450869
83alpha-beta T cell activation (GO:0046631)3.03832710
84T cell differentiation involved in immune response (GO:0002292)3.02736271
85alpha-beta T cell differentiation involved in immune response (GO:0002293)3.02736271
86alpha-beta T cell activation involved in immune response (GO:0002287)3.02736271
87positive regulation of tolerance induction (GO:0002645)3.01706112
88regulation of leukocyte mediated cytotoxicity (GO:0001910)3.00747281
89positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.00343262
90interferon-gamma production (GO:0032609)3.00238352
91negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.00190457
92negative regulation of T-helper cell differentiation (GO:0045623)3.00190457
93regulation of alpha-beta T cell activation (GO:0046634)3.00080158
94negative regulation of interleukin-12 production (GO:0032695)2.98523699
95regulation of T cell mediated immunity (GO:0002709)2.98394869
96regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.97571673
97regulation of natural killer cell mediated immunity (GO:0002715)2.97571673
98positive regulation of mRNA catabolic process (GO:0061014)2.95521593
99positive regulation of alpha-beta T cell activation (GO:0046635)2.95446948
100regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.94672609
101CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.94018189
102defense response to protozoan (GO:0042832)2.93425034
103regulation of isotype switching to IgG isotypes (GO:0048302)2.93143082
104negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.93121946
105angiogenesis involved in wound healing (GO:0060055)2.91149908
106regulation of alpha-beta T cell proliferation (GO:0046640)2.90737827
107* granulocyte activation (GO:0036230)2.89379395
108positive regulation of alpha-beta T cell differentiation (GO:0046638)2.89129333
109negative regulation of interleukin-1 production (GO:0032692)2.88963800
110regulation of T cell tolerance induction (GO:0002664)2.88387916
111T cell migration (GO:0072678)2.85658873
112natural killer cell differentiation (GO:0001779)2.85348695
113negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.83998773
114mast cell activation (GO:0045576)2.82985791
115myeloid cell activation involved in immune response (GO:0002275)2.79416621
116myeloid dendritic cell differentiation (GO:0043011)2.78329298
117response to peptidoglycan (GO:0032494)2.76712050
118B cell proliferation (GO:0042100)2.75609726
119cellular response to interleukin-15 (GO:0071350)2.75604292
120immune response-activating cell surface receptor signaling pathway (GO:0002429)2.75064438
121positive regulation of interleukin-2 production (GO:0032743)2.75009978
122leukocyte homeostasis (GO:0001776)2.74683983
123positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.72950286
124positive regulation of mast cell activation involved in immune response (GO:0033008)2.71763240
125positive regulation of mast cell degranulation (GO:0043306)2.71763240
126leukocyte cell-cell adhesion (GO:0007159)2.70386435
127regulation of T cell receptor signaling pathway (GO:0050856)2.69089510
128negative regulation of B cell proliferation (GO:0030889)2.68919289
129regulation of mast cell degranulation (GO:0043304)2.66892670
130regulation of B cell apoptotic process (GO:0002902)2.66290967
131JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.66046007
132T cell receptor signaling pathway (GO:0050852)2.64337366
133pinocytosis (GO:0006907)2.64029029
134T cell costimulation (GO:0031295)2.63935846
135positive regulation of B cell activation (GO:0050871)2.62462098
136response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.61515857
137response to host immune response (GO:0052572)2.61515857
138negative regulation of granulocyte differentiation (GO:0030853)2.61356835
139response to host (GO:0075136)2.61309496
140response to host defenses (GO:0052200)2.61309496
141response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.61309496
142regulation of mast cell activation (GO:0033003)2.59389652
143regulation of B cell proliferation (GO:0030888)2.58601827
144definitive hemopoiesis (GO:0060216)2.57272505
145lymphocyte costimulation (GO:0031294)2.57212120
146positive regulation of interferon-alpha production (GO:0032727)2.57156879
147response to laminar fluid shear stress (GO:0034616)2.54157557
148neutrophil mediated immunity (GO:0002446)2.50955253
149regulation of histone H3-K9 methylation (GO:0051570)2.50497184
150positive regulation of protein deacetylation (GO:0090312)2.50154584
151interferon-gamma-mediated signaling pathway (GO:0060333)2.49591260
152response to fungus (GO:0009620)2.49358050

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.74331020
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.76279904
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.10103321
4MYC_22102868_ChIP-Seq_BL_Human4.07783320
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.97827035
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.91133222
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.40256214
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.37498693
9VDR_21846776_ChIP-Seq_THP-1_Human3.30851292
10IRF8_21731497_ChIP-ChIP_J774_Mouse3.24447857
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.19755903
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.16583344
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.14204078
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.88415211
15* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.74941768
16* IRF8_27001747_Chip-Seq_BMDM_Mouse2.68731546
17* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.67954480
18* MYB_26560356_Chip-Seq_TH2_Human2.66030758
19SCL_19346495_ChIP-Seq_HPC-7_Human2.65258104
20* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.58522661
21* RUNX_20019798_ChIP-Seq_JUKART_Human2.52991135
22* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.52333261
23* MAF_26560356_Chip-Seq_TH1_Human2.52070880
24* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.45154403
25VDR_24763502_ChIP-Seq_THP-1_Human2.35648116
26* TCF7_22412390_ChIP-Seq_EML_Mouse2.34556347
27* UTX_26944678_Chip-Seq_JUKART_Human2.34114082
28* MYB_26560356_Chip-Seq_TH1_Human2.28695550
29* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.24534815
30STAT4_19710469_ChIP-ChIP_TH1__Mouse2.19509133
31SPI1_23547873_ChIP-Seq_NB4_Human2.12983280
32* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.12089220
33* E2F4_17652178_ChIP-ChIP_JURKAT_Human2.10140356
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.08815844
35* ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.07226057
36RUNX1_22412390_ChIP-Seq_EML_Mouse2.03750928
37CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.01073963
38* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.93102945
39BP1_19119308_ChIP-ChIP_Hs578T_Human1.85589823
40NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.79860125
41LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.79241566
42RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.78687471
43SPI1_23127762_ChIP-Seq_K562_Human1.73393694
44* KDM2B_26808549_Chip-Seq_DND41_Human1.70595438
45IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.67172878
46CIITA_25753668_ChIP-Seq_RAJI_Human1.66619801
47* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.65895618
48* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.64616574
49* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.58042199
50GATA3_27048872_Chip-Seq_THYMUS_Human1.54154255
51FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.53604091
52VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.53126885
53* MAF_26560356_Chip-Seq_TH2_Human1.51572426
54TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48249540
55FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.44373004
56SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.41995541
57* PU_27001747_Chip-Seq_BMDM_Mouse1.39575497
58TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.39156938
59* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.38847419
60GATA2_22383799_ChIP-Seq_G1ME_Mouse1.37030748
61ELK3_25401928_ChIP-Seq_HUVEC_Human1.36771945
62RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.34924469
63STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.32859881
64* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32081567
65HOXB4_20404135_ChIP-ChIP_EML_Mouse1.28291973
66GATA1_22383799_ChIP-Seq_G1ME_Mouse1.22854731
67NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.22446853
68BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.20167715
69ERG_20887958_ChIP-Seq_HPC-7_Mouse1.16749249
70EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.16665300
71Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.16589758
72GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.16460418
73ELF1_17652178_ChIP-ChIP_JURKAT_Human1.16304518
74E2F1_21310950_ChIP-Seq_MCF-7_Human1.16157315
75RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.10057913
76* KDM2B_26808549_Chip-Seq_JURKAT_Human1.09741903
77CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08197368
78SMAD_19615063_ChIP-ChIP_OVARY_Human1.07829265
79STAT6_21828071_ChIP-Seq_BEAS2B_Human1.07157649
80CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04612326
81LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.04327274
82GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03895163
83GATA1_22025678_ChIP-Seq_K562_Human1.03382483
84VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.03033360
85NCOR1_26117541_ChIP-Seq_K562_Human1.02137738
86* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01739483
87* VDR_24787735_ChIP-Seq_THP-1_Human0.99751607
88CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98268657
89PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98022724
90BCL6_27268052_Chip-Seq_Bcells_Human0.97834268
91SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.97560035
92NOTCH1_21737748_ChIP-Seq_TLL_Human0.96651719
93SMRT_27268052_Chip-Seq_Bcells_Human0.96259352
94GATA2_21666600_ChIP-Seq_HMVEC_Human0.95884913
95VDR_23849224_ChIP-Seq_CD4+_Human0.95286763
96TP63_19390658_ChIP-ChIP_HaCaT_Human0.94851326
97GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92601960
98* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90742998
99* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90515564
100TFEB_21752829_ChIP-Seq_HELA_Human0.89276738
101GATA3_26560356_Chip-Seq_TH2_Human0.89064558
102RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.88518937
103GATA1_19941827_ChIP-Seq_MEL_Mouse0.88002457
104GATA3_26560356_Chip-Seq_TH1_Human0.85429073
105CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84630278
106* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.84159033
107ETS1_22383799_ChIP-Seq_G1ME_Mouse0.84040131
108FOXP3_21729870_ChIP-Seq_TREG_Human0.82560087
109* CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.81206474
110* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.81182418
111P300_27268052_Chip-Seq_Bcells_Human0.80024257
112FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.78269996
113ELK1_19687146_ChIP-ChIP_HELA_Human0.77889151
114RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77717576
115KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.77516032
116KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.77516032
117KDM5A_27292631_Chip-Seq_BREAST_Human0.76367527
118SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.75403789
119GATA1_19941826_ChIP-Seq_K562_Human0.71465011
120PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.69600470
121GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.69315262
122GATA2_19941826_ChIP-Seq_K562_Human0.68842318

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.77853468
2MP0003303_peritoneal_inflammation3.75240455
3MP0001800_abnormal_humoral_immune3.39891500
4MP0000685_abnormal_immune_system3.19556424
5MP0005387_immune_system_phenotype3.14423569
6MP0001790_abnormal_immune_system3.14423569
7MP0002452_abnormal_antigen_presenting2.92640985
8MP0002166_altered_tumor_susceptibility2.83428068
9* MP0005000_abnormal_immune_tolerance2.73624857
10MP0005671_abnormal_response_to2.71442071
11* MP0002420_abnormal_adaptive_immunity2.66444630
12MP0002723_abnormal_immune_serum2.63819517
13* MP0002398_abnormal_bone_marrow2.63743350
14* MP0001819_abnormal_immune_cell2.62583284
15MP0002396_abnormal_hematopoietic_system2.62086637
16MP0003763_abnormal_thymus_physiology2.61473648
17MP0003300_gastrointestinal_ulcer2.41356596
18* MP0003436_decreased_susceptibility_to2.40087302
19* MP0000716_abnormal_immune_system2.35121698
20MP0002419_abnormal_innate_immunity2.33825298
21MP0009278_abnormal_bone_marrow2.30147682
22MP0009785_altered_susceptibility_to2.28617981
23MP0000689_abnormal_spleen_morphology2.26472251
24MP0005025_abnormal_response_to2.22166070
25MP0004808_abnormal_hematopoietic_stem2.21715633
26MP0002722_abnormal_immune_system2.17772084
27MP0002405_respiratory_system_inflammati2.12132431
28* MP0000703_abnormal_thymus_morphology2.09020022
29MP0002006_tumorigenesis2.08436114
30* MP0002429_abnormal_blood_cell1.97946149
31MP0002148_abnormal_hypersensitivity_rea1.95209655
32MP0005464_abnormal_platelet_physiology1.88788818
33MP0004510_myositis1.85775982
34MP0010155_abnormal_intestine_physiology1.85477850
35MP0005076_abnormal_cell_differentiation1.77190547
36MP0001873_stomach_inflammation1.75601804
37MP0001545_abnormal_hematopoietic_system1.68300312
38MP0005397_hematopoietic_system_phenotyp1.68300312
39MP0001845_abnormal_inflammatory_respons1.64151608
40MP0001853_heart_inflammation1.60874730
41MP0004947_skin_inflammation1.60248854
42MP0009333_abnormal_splenocyte_physiolog1.59207707
43MP0008057_abnormal_DNA_replication1.57462659
44MP0006054_spinal_hemorrhage1.55118516
45MP0004381_abnormal_hair_follicle1.53022726
46MP0010352_gastrointestinal_tract_polyps1.44278612
47MP0000490_abnormal_crypts_of1.43371328
48MP0005075_abnormal_melanosome_morpholog1.43286795
49MP0000569_abnormal_digit_pigmentation1.37119746
50MP0003183_abnormal_peptide_metabolism1.36058490
51MP0005174_abnormal_tail_pigmentation1.33943412
52MP0003866_abnormal_defecation1.30541197
53MP0002933_joint_inflammation1.30338277
54MP0010094_abnormal_chromosome_stability1.28447813
55MP0003448_altered_tumor_morphology1.23399343
56MP0003077_abnormal_cell_cycle1.21570024
57MP0000858_altered_metastatic_potential1.21375337
58* MP0000465_gastrointestinal_hemorrhage1.21191473
59MP0002009_preneoplasia1.21164917
60MP0010307_abnormal_tumor_latency1.20921403
61MP0002019_abnormal_tumor_incidence1.20440968
62MP0005310_abnormal_salivary_gland1.16924587
63MP0005058_abnormal_lysosome_morphology1.15834495
64MP0006082_CNS_inflammation1.09087378
65MP0003724_increased_susceptibility_to1.07508605
66* MP0001533_abnormal_skeleton_physiology1.06644693
67MP0008007_abnormal_cellular_replicative1.05571295
68MP0001986_abnormal_taste_sensitivity1.00424166
69MP0008469_abnormal_protein_level0.98302740
70MP0003191_abnormal_cellular_cholesterol0.97220385
71MP0002138_abnormal_hepatobiliary_system0.94333179
72MP0001879_abnormal_lymphatic_vessel0.94085578
73MP0003172_abnormal_lysosome_physiology0.92355751
74MP0008961_abnormal_basal_metabolism0.92303569
75MP0001851_eye_inflammation0.90994075
76MP0003111_abnormal_nucleus_morphology0.90985678
77MP0001501_abnormal_sleep_pattern0.90298797
78MP0002998_abnormal_bone_remodeling0.88077659
79MP0002132_abnormal_respiratory_system0.86433403
80MP0002095_abnormal_skin_pigmentation0.85936382
81MP0003828_pulmonary_edema0.85800834
82MP0008995_early_reproductive_senescence0.85107900
83MP0004130_abnormal_muscle_cell0.84216799
84MP0003566_abnormal_cell_adhesion0.84011119
85MP0009763_increased_sensitivity_to0.82959826
86MP0008260_abnormal_autophagy0.82149872
87MP0000343_altered_response_to0.81393987
88MP0003656_abnormal_erythrocyte_physiolo0.80900140
89MP0000015_abnormal_ear_pigmentation0.79943375
90* MP0005390_skeleton_phenotype0.79896345
91MP0000350_abnormal_cell_proliferation0.78286183
92MP0001663_abnormal_digestive_system0.77515218
93MP0003693_abnormal_embryo_hatching0.76721596
94MP0004883_abnormal_blood_vessel0.76291248
95MP0003091_abnormal_cell_migration0.73228510
96MP0000604_amyloidosis0.70432715
97MP0009765_abnormal_xenobiotic_induced0.69679527
98MP0000313_abnormal_cell_death0.68837926
99MP0002277_abnormal_respiratory_mucosa0.68025025
100MP0003453_abnormal_keratinocyte_physiol0.67951038
101MP0005167_abnormal_blood-brain_barrier0.66324477
102MP0001915_intracranial_hemorrhage0.65159717
103* MP0000249_abnormal_blood_vessel0.64432612
104MP0000767_abnormal_smooth_muscle0.63556231
105MP0008058_abnormal_DNA_repair0.63316548
106MP0002928_abnormal_bile_duct0.61546342
107MP0005621_abnormal_cell_physiology0.61226499
108MP0002876_abnormal_thyroid_physiology0.58123826
109MP0003943_abnormal_hepatobiliary_system0.56758676
110MP0004957_abnormal_blastocyst_morpholog0.55973601
111* MP0002136_abnormal_kidney_physiology0.54057243
112MP0003795_abnormal_bone_structure0.53611077
113MP0002877_abnormal_melanocyte_morpholog0.52797847
114MP0009764_decreased_sensitivity_to0.52651871
115MP0005023_abnormal_wound_healing0.52305393
116MP0003252_abnormal_bile_duct0.50329480
117MP0004484_altered_response_of0.50026187
118MP0005166_decreased_susceptibility_to0.50022947
119MP0005164_abnormal_response_to0.48565895
120MP0008877_abnormal_DNA_methylation0.47088989
121MP0003638_abnormal_response/metabolism_0.44662148
122MP0001765_abnormal_ion_homeostasis0.44565312
123MP0000609_abnormal_liver_physiology0.40457454
124MP0005084_abnormal_gallbladder_morpholo0.38549767
125MP0009115_abnormal_fat_cell0.38163995
126MP0002653_abnormal_ependyma_morphology0.37485666
127MP0002083_premature_death0.37345140
128MP0003221_abnormal_cardiomyocyte_apopto0.37272340
129MP0008874_decreased_physiological_sensi0.37143698

Predicted human phenotypes

RankGene SetZ-score
1Cellulitis (HP:0100658)4.98531416
2Agammaglobulinemia (HP:0004432)4.96053529
3Recurrent viral infections (HP:0004429)4.82331951
4B lymphocytopenia (HP:0010976)4.73032835
5Abnormality of B cell number (HP:0010975)4.73032835
6Recurrent abscess formation (HP:0002722)4.71219475
7Thyroiditis (HP:0100646)4.70424531
8Recurrent fungal infections (HP:0002841)4.35734254
9Meningitis (HP:0001287)4.27321101
10Eczematoid dermatitis (HP:0000976)4.25714348
11Panhypogammaglobulinemia (HP:0003139)4.21400484
12Recurrent bacterial skin infections (HP:0005406)4.17456475
13T lymphocytopenia (HP:0005403)3.99563656
14Stomach cancer (HP:0012126)3.95085635
15IgM deficiency (HP:0002850)3.83559107
16Abnormality of T cell number (HP:0011839)3.80838712
17* Papilloma (HP:0012740)3.80041242
18* Verrucae (HP:0200043)3.80041242
19Recurrent bronchitis (HP:0002837)3.75827607
20Gastrointestinal infarctions (HP:0005244)3.51499677
21Severe combined immunodeficiency (HP:0004430)3.50023598
22Chronic otitis media (HP:0000389)3.44822413
23Colitis (HP:0002583)3.44421254
24Osteomyelitis (HP:0002754)3.43044515
25Mediastinal lymphadenopathy (HP:0100721)3.42847543
26Inflammation of the large intestine (HP:0002037)3.42260156
27Gastrointestinal inflammation (HP:0004386)3.37398786
28Abnormal delayed hypersensitivity skin test (HP:0002963)3.35866029
29Abnormality of the prostate (HP:0008775)3.33434182
30Chronic obstructive pulmonary disease (HP:0006510)3.33124447
31Obstructive lung disease (HP:0006536)3.33124447
32Eosinophilia (HP:0001880)3.29815120
33Prostate neoplasm (HP:0100787)3.24831929
34Combined immunodeficiency (HP:0005387)3.24484069
35Myositis (HP:0100614)3.14780936
36Spontaneous hematomas (HP:0007420)3.05940494
37Keratoconjunctivitis (HP:0001096)3.03564290
38Abnormality of the fingertips (HP:0001211)3.03236521
39Abnormality of T cells (HP:0002843)3.02290916
40Recurrent skin infections (HP:0001581)3.00063324
41Autoimmune hemolytic anemia (HP:0001890)2.96718809
42Sepsis (HP:0100806)2.96225413
43Recurrent cutaneous fungal infections (HP:0011370)2.94611238
44Chronic mucocutaneous candidiasis (HP:0002728)2.94611238
45Recurrent gram-negative bacterial infections (HP:0005420)2.88301597
46Abnormality of eosinophils (HP:0001879)2.87475762
47Increased IgM level (HP:0003496)2.84666129
48Granulocytopenia (HP:0001913)2.82086641
49Chronic sinusitis (HP:0011109)2.75361188
50Leukocytosis (HP:0001974)2.73369363
51Vasculitis (HP:0002633)2.73356572
52Recurrent sinusitis (HP:0011108)2.71514697
53Lymphopenia (HP:0001888)2.68238654
54Hypoplasia of the thymus (HP:0000778)2.63607232
55Gastrointestinal stroma tumor (HP:0100723)2.63184152
56Abnormality of cells of the lymphoid lineage (HP:0012140)2.62992185
57Elevated erythrocyte sedimentation rate (HP:0003565)2.60270933
58Small epiphyses (HP:0010585)2.47385518
59Increased density of long bones (HP:0006392)2.47009132
60Recurrent pneumonia (HP:0006532)2.46501705
61Abnormality of macrophages (HP:0004311)2.46284338
62Prolonged bleeding time (HP:0003010)2.43749370
63Chronic diarrhea (HP:0002028)2.41929603
64Thrombocytosis (HP:0001894)2.41834653
65Gangrene (HP:0100758)2.40833704
66Abnormality of the intervertebral disk (HP:0005108)2.40821594
67Periodontitis (HP:0000704)2.37474118
68Pulmonary embolism (HP:0002204)2.35949124
69Optic neuritis (HP:0100653)2.34491200
70Retrobulbar optic neuritis (HP:0100654)2.34491200
71Orchitis (HP:0100796)2.34082231
72Urticaria (HP:0001025)2.28348160
73Abnormality of the pleura (HP:0002103)2.28238023
74Alveolar cell carcinoma (HP:0006519)2.26854716
75Chest pain (HP:0100749)2.25050691
76Abnormality of male internal genitalia (HP:0000022)2.24118872
77Hematochezia (HP:0002573)2.23695422
78Recurrent lower respiratory tract infections (HP:0002783)2.23656594
79Joint swelling (HP:0001386)2.23430066
80Encephalitis (HP:0002383)2.22339935
81Arterial thrombosis (HP:0004420)2.22092212
82Increased IgE level (HP:0003212)2.20781675
83Pulmonary fibrosis (HP:0002206)2.20747892
84Pustule (HP:0200039)2.20732292
85Gingivitis (HP:0000230)2.20066409
86Nasal polyposis (HP:0100582)2.20014278
87Pulmonary infiltrates (HP:0002113)2.19637916
88Abnormality of T cell physiology (HP:0011840)2.18645704
89Autoimmune thrombocytopenia (HP:0001973)2.16511541
90Hypergammaglobulinemia (HP:0010702)2.16303152
91Lymphoma (HP:0002665)2.16074007
92Skin ulcer (HP:0200042)2.13638810
93Stomatitis (HP:0010280)2.11032613
94Volvulus (HP:0002580)2.10502078
95* IgG deficiency (HP:0004315)2.09389808
96Interstitial pulmonary disease (HP:0006530)2.09024449
97Emphysema (HP:0002097)2.08272942
98Episodic fever (HP:0001954)2.08100844
99Neoplasm of the tracheobronchial system (HP:0100552)2.08037681
100Vertebral arch anomaly (HP:0008438)2.07097528
101Anorexia (HP:0002039)2.07036072
102Glomerulopathy (HP:0100820)2.05500710
103Keratitis (HP:0000491)2.04966588
104Bronchitis (HP:0012387)2.04023161
105Aplasia/Hypoplasia of the thymus (HP:0010515)2.00436937
106Abnormal platelet volume (HP:0011876)1.98814859
107Supernumerary bones of the axial skeleton (HP:0009144)1.97600317
108Epistaxis (HP:0000421)1.97354428
109Viral hepatitis (HP:0006562)1.97150082
110Skin rash (HP:0000988)1.96643754
111Premature loss of primary teeth (HP:0006323)1.96544798
112Abnormality of the nasal mucosa (HP:0000433)1.95890065
113Cutis marmorata (HP:0000965)1.94899925
114Petechiae (HP:0000967)1.92743122
115Supernumerary ribs (HP:0005815)1.91234914
116Basal cell carcinoma (HP:0002671)1.88719084
117Keratoconjunctivitis sicca (HP:0001097)1.88708532
118Restrictive lung disease (HP:0002091)1.88328583
119Recurrent otitis media (HP:0000403)1.88188215
120Mitral stenosis (HP:0001718)1.85528405
121Hemoptysis (HP:0002105)1.83945612
122Hypochromic anemia (HP:0001931)1.83758410
123Persistence of primary teeth (HP:0006335)1.83263967
124Abnormality of the thymus (HP:0000777)1.80830693
125Long eyelashes (HP:0000527)1.79908314
126Increased cerebral lipofuscin (HP:0011813)1.79573060
127Papilledema (HP:0001085)1.78133916
128Bicuspid aortic valve (HP:0001647)1.77981157
129IgA deficiency (HP:0002720)1.77512375

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K104.58084884
2MAP4K14.31878790
3EEF2K2.59719005
4STK102.45210073
5MAP2K22.43606704
6BTK2.30055690
7IRAK42.13873200
8SYK2.03441780
9MAP3K142.00894207
10BLK1.98656729
11ITK1.96130712
12CDK121.92408735
13ERN11.87333673
14LRRK21.83185877
15TYK21.81681885
16CSF1R1.73890041
17TEC1.69555814
18CLK11.66405109
19TRIB31.64474120
20BMPR21.56023079
21KIT1.53796758
22ZAP701.52554968
23TGFBR21.52118669
24RIPK41.50255969
25FGFR31.49530095
26HCK1.47913848
27CSK1.46204409
28EPHB11.45485874
29PRPF4B1.43585001
30PKN21.42947060
31STK41.41835136
32TBK11.41328859
33TXK1.40030023
34EIF2AK31.39283679
35JAK11.34922332
36JAK31.32401616
37FES1.31260166
38TLK11.29300116
39* GRK61.28700024
40SIK21.25977218
41IKBKB1.24728802
42IRAK11.17238686
43TAOK31.17026065
44TESK21.16243863
45IKBKE1.14868288
46NLK1.14735211
47LCK1.12167185
48CDK41.12101842
49* PIM11.11012121
50LYN1.09565773
51NEK21.07106125
52CAMKK21.06142323
53CHUK1.06012271
54FGFR41.00464761
55MAPK150.97547015
56MST40.97530658
57MAP2K30.96708043
58CDK60.95433547
59CDK90.95405831
60IRAK30.95342844
61HIPK20.94211516
62KDR0.92736794
63CAMKK10.90579825
64PTK60.89225882
65TRPM70.83979229
66RPS6KA40.81392081
67MARK30.80450691
68DYRK1B0.79514988
69SIK30.79204283
70MAP3K130.73069560
71MAP3K80.72172959
72MAPK40.71974414
73RPS6KB20.71403218
74BRD40.70331357
75MAPK120.68835100
76CDC70.67907358
77JAK20.67360932
78ALK0.65219814
79MAP3K110.63285193
80MATK0.63135274
81PRKCQ0.62675081
82TNK20.62016341
83FGFR20.56980301
84TSSK60.55533322
85MAPK110.54533352
86PDK10.54144724
87IRAK20.53157835
88MARK20.52804838
89SGK30.52296739
90PIK3CG0.51516473
91MELK0.51179661
92DYRK30.50688787
93YES10.49876574
94RPS6KA60.49197039
95PRKD20.47404334
96RPS6KA50.46993366
97TTN0.45653126
98RPS6KL10.43759492
99RPS6KC10.43759492
100MAPK70.43392379
101GRK70.43021840
102MAP3K10.42999923
103FLT30.42729778
104MAPKAPK20.41821559
105MAP3K70.41725530
106EPHA30.41578162
107ADRBK20.40446658
108STK240.40252613
109PASK0.39609112
110MAPK30.39447594
111ABL10.39363510
112PAK40.39105065
113ATR0.38787985
114PDGFRB0.38768761
115FGR0.36856453
116SIK10.33551864
117KSR20.33107266
118RPS6KA10.33096621
119PRKD10.32273327
120EGFR0.32145253
121FYN0.30151263
122RPS6KA20.29450184
123INSR0.29315556
124IGF1R0.28417002
125TAOK10.27856282
126CAMK40.27699617
127NUAK10.26396739
128MOS0.24679126
129INSRR0.24587880
130CDC42BPA0.24188151
131CDK80.24162022

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.74413187
2B cell receptor signaling pathway_Homo sapiens_hsa046623.37235033
3Autoimmune thyroid disease_Homo sapiens_hsa053202.88296374
4NF-kappa B signaling pathway_Homo sapiens_hsa040642.46568253
5Osteoclast differentiation_Homo sapiens_hsa043802.46051987
6Leishmaniasis_Homo sapiens_hsa051402.37714334
7Type I diabetes mellitus_Homo sapiens_hsa049402.19121771
8Antigen processing and presentation_Homo sapiens_hsa046122.04918896
9Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.01887784
10T cell receptor signaling pathway_Homo sapiens_hsa046601.98101709
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.94961375
12Measles_Homo sapiens_hsa051621.93640537
13Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.86311434
14Non-homologous end-joining_Homo sapiens_hsa034501.79977077
15Chronic myeloid leukemia_Homo sapiens_hsa052201.72232048
16Hematopoietic cell lineage_Homo sapiens_hsa046401.71517496
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.65236130
18* Intestinal immune network for IgA production_Homo sapiens_hsa046721.62834493
19Acute myeloid leukemia_Homo sapiens_hsa052211.62593652
20Systemic lupus erythematosus_Homo sapiens_hsa053221.56323813
21Toll-like receptor signaling pathway_Homo sapiens_hsa046201.53101982
22Transcriptional misregulation in cancer_Homo sapiens_hsa052021.49396469
23Toxoplasmosis_Homo sapiens_hsa051451.46354804
24Herpes simplex infection_Homo sapiens_hsa051681.43093190
25Hepatitis B_Homo sapiens_hsa051611.40522940
26NOD-like receptor signaling pathway_Homo sapiens_hsa046211.40008626
27Tuberculosis_Homo sapiens_hsa051521.39475454
28Rheumatoid arthritis_Homo sapiens_hsa053231.37464265
29Viral carcinogenesis_Homo sapiens_hsa052031.37358593
30Apoptosis_Homo sapiens_hsa042101.37080992
31DNA replication_Homo sapiens_hsa030301.36703857
32Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.36104541
33* Chemokine signaling pathway_Homo sapiens_hsa040621.34024938
34Pancreatic cancer_Homo sapiens_hsa052121.32496222
35Non-small cell lung cancer_Homo sapiens_hsa052231.31991204
36Base excision repair_Homo sapiens_hsa034101.31672332
37* Leukocyte transendothelial migration_Homo sapiens_hsa046701.30207974
38Shigellosis_Homo sapiens_hsa051311.28101403
39Jak-STAT signaling pathway_Homo sapiens_hsa046301.26088373
40Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.21580056
41Influenza A_Homo sapiens_hsa051641.19722453
42RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.18372839
43Epstein-Barr virus infection_Homo sapiens_hsa051691.18243100
44Neurotrophin signaling pathway_Homo sapiens_hsa047221.13660995
45Platelet activation_Homo sapiens_hsa046111.11172143
46Legionellosis_Homo sapiens_hsa051341.10220054
47Colorectal cancer_Homo sapiens_hsa052101.10157270
48TNF signaling pathway_Homo sapiens_hsa046681.07856215
49Viral myocarditis_Homo sapiens_hsa054161.06241885
50HTLV-I infection_Homo sapiens_hsa051661.05212121
51AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.04586016
52Small cell lung cancer_Homo sapiens_hsa052221.04373132
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.02092554
54MicroRNAs in cancer_Homo sapiens_hsa052061.01174755
55Pertussis_Homo sapiens_hsa051331.00071047
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.99696673
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.95278042
58Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.93584846
59Notch signaling pathway_Homo sapiens_hsa043300.93017178
60FoxO signaling pathway_Homo sapiens_hsa040680.93013796
61Spliceosome_Homo sapiens_hsa030400.92030914
62Malaria_Homo sapiens_hsa051440.86263661
63Staphylococcus aureus infection_Homo sapiens_hsa051500.85618409
64Cell cycle_Homo sapiens_hsa041100.83155334
65Salmonella infection_Homo sapiens_hsa051320.83021015
66Prostate cancer_Homo sapiens_hsa052150.82923854
67Endometrial cancer_Homo sapiens_hsa052130.82304788
68Mismatch repair_Homo sapiens_hsa034300.81155256
69VEGF signaling pathway_Homo sapiens_hsa043700.78343164
70Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.76967600
71Glycosaminoglycan degradation_Homo sapiens_hsa005310.75384216
72Hepatitis C_Homo sapiens_hsa051600.74882653
73Prolactin signaling pathway_Homo sapiens_hsa049170.73519897
74Other glycan degradation_Homo sapiens_hsa005110.70702123
75Alcoholism_Homo sapiens_hsa050340.70278845
76p53 signaling pathway_Homo sapiens_hsa041150.69419736
77Renal cell carcinoma_Homo sapiens_hsa052110.69161630
78Glioma_Homo sapiens_hsa052140.66639932
79Regulation of autophagy_Homo sapiens_hsa041400.65810961
80Dorso-ventral axis formation_Homo sapiens_hsa043200.65647362
81Lysosome_Homo sapiens_hsa041420.64097632
82Ribosome_Homo sapiens_hsa030100.62973681
83mTOR signaling pathway_Homo sapiens_hsa041500.62226243
84African trypanosomiasis_Homo sapiens_hsa051430.60747996
85Asthma_Homo sapiens_hsa053100.60336764
86Allograft rejection_Homo sapiens_hsa053300.60009593
87Proteoglycans in cancer_Homo sapiens_hsa052050.59802231
88Phagosome_Homo sapiens_hsa041450.58698738
89Graft-versus-host disease_Homo sapiens_hsa053320.58490217
90Regulation of actin cytoskeleton_Homo sapiens_hsa048100.58250639
91mRNA surveillance pathway_Homo sapiens_hsa030150.56856018
92* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.56655853
93Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55954005
94Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.54808865
95MAPK signaling pathway_Homo sapiens_hsa040100.54673760
96SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54216463
97Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53543916
98HIF-1 signaling pathway_Homo sapiens_hsa040660.53476528
99Insulin resistance_Homo sapiens_hsa049310.52820018
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.50369077
101* Endocytosis_Homo sapiens_hsa041440.49410060
102Inositol phosphate metabolism_Homo sapiens_hsa005620.49184303
103Circadian rhythm_Homo sapiens_hsa047100.48329306
104Phospholipase D signaling pathway_Homo sapiens_hsa040720.47760739
105* Pathways in cancer_Homo sapiens_hsa052000.47223065
106Sphingolipid signaling pathway_Homo sapiens_hsa040710.46447661
107Lysine degradation_Homo sapiens_hsa003100.43241154
108Adipocytokine signaling pathway_Homo sapiens_hsa049200.43150960
109Homologous recombination_Homo sapiens_hsa034400.39141982
110Choline metabolism in cancer_Homo sapiens_hsa052310.38701589
111Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.37803878
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36462053
113Carbohydrate digestion and absorption_Homo sapiens_hsa049730.35916209
114Adherens junction_Homo sapiens_hsa045200.35562706
115Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.32599675
116alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30048014
117Glycerophospholipid metabolism_Homo sapiens_hsa005640.29770854
118Arachidonic acid metabolism_Homo sapiens_hsa005900.27801746
119Ras signaling pathway_Homo sapiens_hsa040140.27492873
120Linoleic acid metabolism_Homo sapiens_hsa005910.26881801
121Morphine addiction_Homo sapiens_hsa050320.26681773
122Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.25733907
123Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.20820472

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