CXCR5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a multi-pass membrane protein that belongs to the CXC chemokine receptor family. It is expressed in mature B-cells and Burkitt's lymphoma. This cytokine receptor binds to B-lymphocyte chemoattractant (BLC), and is involved in B-cell migration into B-cell follicles of spleen and Peyer patches. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous antigen (GO:0019883)8.07330196
2B cell receptor signaling pathway (GO:0050853)7.92104992
3regulation of B cell receptor signaling pathway (GO:0050855)7.11304564
4positive regulation of gamma-delta T cell activation (GO:0046645)7.03011376
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.24643558
6antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.24643558
7positive thymic T cell selection (GO:0045059)6.16555590
8cellular response to interleukin-15 (GO:0071350)5.71547532
9response to interleukin-15 (GO:0070672)5.62202410
10regulation of gamma-delta T cell differentiation (GO:0045586)5.55155616
11regulation of B cell differentiation (GO:0045577)5.41648104
12cellular response to zinc ion (GO:0071294)5.39313166
13mature B cell differentiation (GO:0002335)5.26741434
14negative thymic T cell selection (GO:0045060)5.24517479
15regulation of gamma-delta T cell activation (GO:0046643)5.10420794
16negative T cell selection (GO:0043383)5.07312775
17positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.00262783
18B cell proliferation (GO:0042100)4.97731709
19thymic T cell selection (GO:0045061)4.92241404
20positive T cell selection (GO:0043368)4.85758992
21negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.82064341
22negative regulation of cell killing (GO:0031342)4.82064341
23regulation of interleukin-12 biosynthetic process (GO:0045075)4.60280811
24T cell selection (GO:0045058)4.58687261
25antigen receptor-mediated signaling pathway (GO:0050851)4.55199838
26regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.53446588
27positive regulation of B cell differentiation (GO:0045579)4.45267072
28negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)4.33089160
29regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.28126355
30tolerance induction (GO:0002507)4.27472481
31regulation of B cell proliferation (GO:0030888)4.26563410
32NIK/NF-kappaB signaling (GO:0038061)4.23327466
33regulation of interferon-beta biosynthetic process (GO:0045357)4.14999404
34positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.13014292
35regulation of antigen processing and presentation (GO:0002577)4.12260487
36detection of bacterium (GO:0016045)4.11426761
37mature B cell differentiation involved in immune response (GO:0002313)4.04600040
38neutrophil activation involved in immune response (GO:0002283)3.99015179
39regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.95917243
40detection of other organism (GO:0098543)3.95189552
41negative regulation of T cell mediated immunity (GO:0002710)3.90286019
42regulation of alpha-beta T cell proliferation (GO:0046640)3.88271975
43positive regulation of B cell proliferation (GO:0030890)3.87516945
44positive regulation of interleukin-2 production (GO:0032743)3.84399601
45immune response-activating cell surface receptor signaling pathway (GO:0002429)3.79124727
46T cell costimulation (GO:0031295)3.78889697
47negative regulation of B cell proliferation (GO:0030889)3.78073206
48negative regulation of lymphocyte mediated immunity (GO:0002707)3.77899525
49defense response to protozoan (GO:0042832)3.74699322
50B cell homeostasis (GO:0001782)3.71902414
51lymphocyte costimulation (GO:0031294)3.71827671
52negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.66471761
53CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.66176764
54type I interferon signaling pathway (GO:0060337)3.65305071
55cellular response to type I interferon (GO:0071357)3.65305071
56response to type I interferon (GO:0034340)3.63149287
57leukocyte aggregation (GO:0070486)3.61789946
58T cell migration (GO:0072678)3.60903886
59lymphocyte homeostasis (GO:0002260)3.57620194
60macrophage activation involved in immune response (GO:0002281)3.56413372
61negative regulation of T-helper cell differentiation (GO:0045623)3.55533562
62negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.55533562
63regulation of T cell tolerance induction (GO:0002664)3.54447639
64negative regulation of bone resorption (GO:0045779)3.53752810
65germinal center formation (GO:0002467)3.52425589
66regulation of T cell mediated cytotoxicity (GO:0001914)3.48777366
67modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.48587837
68positive regulation by organism of defense response of other organism involved in symbiotic interact3.48587837
69modulation by symbiont of host immune response (GO:0052553)3.48587837
70positive regulation by symbiont of host defense response (GO:0052509)3.48587837
71modulation by symbiont of host defense response (GO:0052031)3.48587837
72modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.48587837
73viral transcription (GO:0019083)3.48550888
74positive regulation of B cell activation (GO:0050871)3.46656536
75negative regulation of alpha-beta T cell activation (GO:0046636)3.45133186
76interferon-gamma-mediated signaling pathway (GO:0060333)3.43456249
77regulation of T-helper 1 cell differentiation (GO:0045625)3.43043391
78positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.41563086
79regulation of T cell receptor signaling pathway (GO:0050856)3.40686933
80cytidine metabolic process (GO:0046087)3.40655419
81cytidine catabolic process (GO:0006216)3.40655419
82cytidine deamination (GO:0009972)3.40655419
83regulation of B cell apoptotic process (GO:0002902)3.40566362
84negative regulation of interleukin-12 production (GO:0032695)3.40370606
85regulation of B cell activation (GO:0050864)3.39806387
86T cell homeostasis (GO:0043029)3.39428346
87positive regulation of immunoglobulin production (GO:0002639)3.37896734
88* B cell activation (GO:0042113)3.37039391
89T cell receptor signaling pathway (GO:0050852)3.36441177
90production of molecular mediator involved in inflammatory response (GO:0002532)3.34297140
91response to protozoan (GO:0001562)3.30855864
92negative regulation of leukocyte mediated immunity (GO:0002704)3.30640133
93regulation of dendritic cell antigen processing and presentation (GO:0002604)3.30570664
94negative regulation of B cell apoptotic process (GO:0002903)3.29793752
95immunoglobulin mediated immune response (GO:0016064)3.27459536
96neutrophil activation (GO:0042119)3.26231837
97JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.25791785
98negative regulation of phagocytosis (GO:0050765)3.25667996
99translational termination (GO:0006415)3.23771514
100lymphocyte proliferation (GO:0046651)3.22871698
101mononuclear cell proliferation (GO:0032943)3.20590991
102positive regulation of T cell mediated cytotoxicity (GO:0001916)3.18561155
103regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.18241036
104regulation of natural killer cell mediated immunity (GO:0002715)3.18241036
105myeloid cell activation involved in immune response (GO:0002275)3.18207464
106positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.17109938
107positive regulation of antigen processing and presentation (GO:0002579)3.15742513
108ribosomal small subunit assembly (GO:0000028)3.14808792
109B cell mediated immunity (GO:0019724)3.14167676
110regulation of tolerance induction (GO:0002643)3.13371704
111granulocyte activation (GO:0036230)3.12774224
112positive regulation of interferon-alpha production (GO:0032727)3.11933009
113respiratory burst (GO:0045730)3.11218095
114positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.10777340
115mast cell activation (GO:0045576)3.09806435
116positive regulation of type 2 immune response (GO:0002830)3.09624964
117myeloid dendritic cell differentiation (GO:0043011)3.09041859
118leukocyte homeostasis (GO:0001776)3.07880605
119regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.07493111
120leukocyte degranulation (GO:0043299)3.06756650
121negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.04964792
122positive regulation of Rap GTPase activity (GO:0032854)3.04550360
123regulation of alpha-beta T cell activation (GO:0046634)3.03293409
124activated T cell proliferation (GO:0050798)3.02999561
125regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.00593067
126regulation of interferon-alpha production (GO:0032647)2.99323466
127positive regulation of granulocyte differentiation (GO:0030854)2.97863047
128negative regulation of T cell receptor signaling pathway (GO:0050860)2.97261870
129leukocyte proliferation (GO:0070661)2.96387119
130regulation of isotype switching to IgG isotypes (GO:0048302)2.93193728
131ribosomal small subunit biogenesis (GO:0042274)2.92780173
132positive regulation of cytokine biosynthetic process (GO:0042108)2.92666527
133myeloid dendritic cell activation (GO:0001773)2.92277034
134B cell activation involved in immune response (GO:0002312)2.91516055
135B cell differentiation (GO:0030183)2.89651664
136negative regulation of calcium ion transport into cytosol (GO:0010523)2.89178184
137positive regulation of isotype switching (GO:0045830)2.86422352
138positive regulation of histone deacetylation (GO:0031065)2.83807262
139immune response-activating signal transduction (GO:0002757)2.82458346
140interferon-gamma production (GO:0032609)2.82348474
141positive regulation of interleukin-12 production (GO:0032735)2.81831565
142negative regulation of bone remodeling (GO:0046851)2.81346898
143regulation of interleukin-2 biosynthetic process (GO:0045076)2.80211142
144regulation of immunoglobulin production (GO:0002637)2.79691162
145chaperone mediated protein folding requiring cofactor (GO:0051085)2.76629172
146regulation of regulatory T cell differentiation (GO:0045589)2.75261578
147antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.74255443
148T cell proliferation (GO:0042098)2.74178268

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.69839711
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.41982811
3IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.91873001
4MYC_22102868_ChIP-Seq_BL_Human4.76433302
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.61416923
6SPI1_22096565_ChIP-ChIP_GC-B_Mouse4.10333073
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.55391120
8VDR_21846776_ChIP-Seq_THP-1_Human3.20468099
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.18169962
10* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.16838121
11RUNX_20019798_ChIP-Seq_JUKART_Human3.14440434
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.86177354
13* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.80913221
14* MYB_26560356_Chip-Seq_TH2_Human2.80406837
15IRF8_27001747_Chip-Seq_BMDM_Mouse2.79832745
16MAF_26560356_Chip-Seq_TH1_Human2.79298912
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.73441002
18NOTCH1_21737748_ChIP-Seq_TLL_Human2.70074295
19* MYB_26560356_Chip-Seq_TH1_Human2.66970361
20E2F7_22180533_ChIP-Seq_HELA_Human2.63530302
21STAT4_19710469_ChIP-ChIP_TH1__Mouse2.61683679
22BP1_19119308_ChIP-ChIP_Hs578T_Human2.52627489
23UTX_26944678_Chip-Seq_JUKART_Human2.46568511
24IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.45966106
25NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.40143554
26VDR_24763502_ChIP-Seq_THP-1_Human2.27345468
27SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.19656872
28SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.17806584
29VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.08746120
30NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.08249838
31* TCF7_22412390_ChIP-Seq_EML_Mouse2.06817173
32KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.05413080
33SPI1_23547873_ChIP-Seq_NB4_Human2.03177010
34SCL_19346495_ChIP-Seq_HPC-7_Human1.99347470
35* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.95782168
36CIITA_25753668_ChIP-Seq_RAJI_Human1.93290251
37* MAF_26560356_Chip-Seq_TH2_Human1.92316508
38* RUNX1_22412390_ChIP-Seq_EML_Mouse1.81200708
39RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.79840345
40KDM2B_26808549_Chip-Seq_SUP-B15_Human1.77426329
41KDM2B_26808549_Chip-Seq_DND41_Human1.76723923
42GATA3_27048872_Chip-Seq_THYMUS_Human1.66876153
43MYB_21317192_ChIP-Seq_ERMYB_Mouse1.63442394
44FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.62888624
45NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.60947911
46BRD4_27068464_Chip-Seq_AML-cells_Mouse1.56151309
47* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.53234910
48SPI1_23127762_ChIP-Seq_K562_Human1.52814855
49TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.50628702
50IKZF1_21737484_ChIP-ChIP_HCT116_Human1.44770424
51KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.44015120
52* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.42000472
53GATA2_22383799_ChIP-Seq_G1ME_Mouse1.32585421
54BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.31880806
55SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.31183902
56ELK3_25401928_ChIP-Seq_HUVEC_Human1.28738155
57MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.27710195
58FOXM1_23109430_ChIP-Seq_U2OS_Human1.27472979
59* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.23955417
60TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23517598
61BCOR_27268052_Chip-Seq_Bcells_Human1.21989954
62NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.19707454
63STAT6_21828071_ChIP-Seq_BEAS2B_Human1.19326258
64ELF1_17652178_ChIP-ChIP_JURKAT_Human1.16633541
65CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15445166
66PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13787550
67PU_27001747_Chip-Seq_BMDM_Mouse1.12787958
68* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11925061
69VDR_23849224_ChIP-Seq_CD4+_Human1.10245017
70FOXP3_21729870_ChIP-Seq_TREG_Human1.09496001
71GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09472390
72CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.09232512
73GATA1_22383799_ChIP-Seq_G1ME_Mouse1.07405556
74GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.06286236
75* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.03786318
76KDM2B_26808549_Chip-Seq_JURKAT_Human1.02561049
77* GATA3_26560356_Chip-Seq_TH2_Human1.02018157
78* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99486819
79RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.99242863
80ERG_20887958_ChIP-Seq_HPC-7_Mouse0.98022591
81THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.97995068
82LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.96814376
83PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94510067
84EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.94452923
85VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.92355055
86RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.90372524
87SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.89742784
88ELF1_20517297_ChIP-Seq_JURKAT_Human0.88286340
89NCOR1_26117541_ChIP-Seq_K562_Human0.86400626
90HOXB4_20404135_ChIP-ChIP_EML_Mouse0.85478959
91P68_20966046_ChIP-Seq_HELA_Human0.84775988
92GATA1_22025678_ChIP-Seq_K562_Human0.84603750
93KDM5A_27292631_Chip-Seq_BREAST_Human0.83878403
94Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.82270878
95SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82151230
96P300_27268052_Chip-Seq_Bcells_Human0.81516087
97E2F1_20622854_ChIP-Seq_HELA_Human0.80699784
98PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80229218
99VDR_24787735_ChIP-Seq_THP-1_Human0.80139043
100SMAD_19615063_ChIP-ChIP_OVARY_Human0.79653547
101SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.79606819
102DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.77643782
103EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.77576977
104* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.77107066
105* SMRT_27268052_Chip-Seq_Bcells_Human0.77099356
106XRN2_22483619_ChIP-Seq_HELA_Human0.75720630
107GATA1_19941827_ChIP-Seq_MEL_Mouse0.75078799
108FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74868217
109RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74488765
110GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.74110454
111BCL6_27268052_Chip-Seq_Bcells_Human0.70991212
112MYC_19079543_ChIP-ChIP_MESCs_Mouse0.70461298
113LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.70117011
114PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.70065380
115* LXR_22292898_ChIP-Seq_THP-1_Human0.69763079
116CTCF_27219007_Chip-Seq_ERYTHROID_Human0.69730840
117CTCF_26484167_Chip-Seq_Bcells_Mouse0.69223852
118CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.67777539
119SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.67173177

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.43332348
2MP0005387_immune_system_phenotype5.02648265
3MP0001790_abnormal_immune_system5.02648265
4MP0001800_abnormal_humoral_immune4.94613054
5MP0000685_abnormal_immune_system4.03682527
6MP0002452_abnormal_antigen_presenting3.74457322
7MP0005671_abnormal_response_to3.61324168
8MP0003763_abnormal_thymus_physiology3.51234830
9MP0005000_abnormal_immune_tolerance3.48390103
10MP0002723_abnormal_immune_serum3.29448023
11MP0003303_peritoneal_inflammation3.26002479
12* MP0002420_abnormal_adaptive_immunity3.19177849
13* MP0001819_abnormal_immune_cell3.09024036
14MP0002398_abnormal_bone_marrow2.99394948
15* MP0000716_abnormal_immune_system2.73028420
16* MP0000689_abnormal_spleen_morphology2.54391138
17MP0001873_stomach_inflammation2.51248662
18MP0004510_myositis2.23696649
19* MP0002429_abnormal_blood_cell2.21567592
20MP0005025_abnormal_response_to2.19565926
21* MP0002722_abnormal_immune_system2.19066882
22MP0002405_respiratory_system_inflammati2.13568958
23MP0002166_altered_tumor_susceptibility2.09045960
24MP0002148_abnormal_hypersensitivity_rea2.07214963
25MP0002419_abnormal_innate_immunity1.99476816
26MP0009785_altered_susceptibility_to1.99212221
27MP0003300_gastrointestinal_ulcer1.97116567
28MP0002396_abnormal_hematopoietic_system1.87044910
29MP0010155_abnormal_intestine_physiology1.86312349
30MP0009333_abnormal_splenocyte_physiolog1.86106362
31MP0000703_abnormal_thymus_morphology1.85769874
32MP0003436_decreased_susceptibility_to1.81828430
33MP0001845_abnormal_inflammatory_respons1.78399688
34MP0001853_heart_inflammation1.65912191
35MP0002933_joint_inflammation1.64679239
36MP0004947_skin_inflammation1.61932913
37MP0003172_abnormal_lysosome_physiology1.59609211
38MP0003866_abnormal_defecation1.59107181
39MP0004381_abnormal_hair_follicle1.46687412
40MP0004808_abnormal_hematopoietic_stem1.46055408
41MP0002006_tumorigenesis1.41526523
42MP0008057_abnormal_DNA_replication1.40498282
43MP0005310_abnormal_salivary_gland1.38068628
44MP0000465_gastrointestinal_hemorrhage1.31333599
45MP0005464_abnormal_platelet_physiology1.27598962
46MP0005174_abnormal_tail_pigmentation1.18636929
47MP0002254_reproductive_system_inflammat1.17120279
48MP0003183_abnormal_peptide_metabolism1.15871372
49MP0006082_CNS_inflammation1.06890781
50MP0001851_eye_inflammation1.02672364
51MP0002138_abnormal_hepatobiliary_system1.00844625
52MP0010234_abnormal_vibrissa_follicle0.99087440
53MP0010352_gastrointestinal_tract_polyps0.96878404
54MP0002136_abnormal_kidney_physiology0.95621902
55MP0008469_abnormal_protein_level0.95008915
56MP0002019_abnormal_tumor_incidence0.94128855
57MP0003091_abnormal_cell_migration0.93364808
58MP0009278_abnormal_bone_marrow0.91716965
59MP0008961_abnormal_basal_metabolism0.91566180
60MP0003191_abnormal_cellular_cholesterol0.89618300
61MP0003077_abnormal_cell_cycle0.87656106
62MP0000490_abnormal_crypts_of0.84611893
63MP0003045_fibrosis0.82225440
64MP0009840_abnormal_foam_cell0.77689349
65MP0008004_abnormal_stomach_pH0.77576482
66MP0005076_abnormal_cell_differentiation0.74759346
67MP0003787_abnormal_imprinting0.74213475
68MP0004883_abnormal_blood_vessel0.74168507
69MP0005075_abnormal_melanosome_morpholog0.72543923
70MP0000569_abnormal_digit_pigmentation0.71129813
71MP0000015_abnormal_ear_pigmentation0.70414669
72MP0001663_abnormal_digestive_system0.68991651
73MP0001533_abnormal_skeleton_physiology0.67707532
74MP0002095_abnormal_skin_pigmentation0.67631275
75MP0003724_increased_susceptibility_to0.67267625
76MP0008260_abnormal_autophagy0.66170728
77MP0001879_abnormal_lymphatic_vessel0.64348806
78MP0010094_abnormal_chromosome_stability0.63696075
79MP0000858_altered_metastatic_potential0.62960681
80MP0002928_abnormal_bile_duct0.62958535
81MP0009765_abnormal_xenobiotic_induced0.62508050
82MP0002653_abnormal_ependyma_morphology0.61760965
83MP0005390_skeleton_phenotype0.61680036
84MP0005381_digestive/alimentary_phenotyp0.61418851
85MP0002009_preneoplasia0.58740430
86MP0000249_abnormal_blood_vessel0.57677344
87MP0001764_abnormal_homeostasis0.55027927
88MP0003448_altered_tumor_morphology0.53679522
89MP0006054_spinal_hemorrhage0.53495350
90MP0000350_abnormal_cell_proliferation0.52687755
91MP0000767_abnormal_smooth_muscle0.51917432
92MP0008874_decreased_physiological_sensi0.49961873
93MP0002909_abnormal_adrenal_gland0.49557164
94MP0005166_decreased_susceptibility_to0.49410415
95MP0002132_abnormal_respiratory_system0.48543347
96MP0003693_abnormal_embryo_hatching0.48536075
97MP0003795_abnormal_bone_structure0.48440878
98MP0009764_decreased_sensitivity_to0.48034327
99MP0002998_abnormal_bone_remodeling0.47486963
100MP0001348_abnormal_lacrimal_gland0.47301195
101MP0005058_abnormal_lysosome_morphology0.46478482
102MP0000313_abnormal_cell_death0.46328698
103MP0005621_abnormal_cell_physiology0.45885288
104MP0008058_abnormal_DNA_repair0.45759949
105MP0005451_abnormal_body_composition0.45470142
106MP0001545_abnormal_hematopoietic_system0.45117172
107MP0005397_hematopoietic_system_phenotyp0.45117172
108MP0002277_abnormal_respiratory_mucosa0.44109767
109MP0003828_pulmonary_edema0.44033201
110MP0002168_other_aberrant_phenotype0.43372118
111MP0008873_increased_physiological_sensi0.42811179
112MP0003453_abnormal_keratinocyte_physiol0.42506392
113MP0000477_abnormal_intestine_morphology0.42010920
114MP0003279_aneurysm0.41592727
115MP0003075_altered_response_to0.40826726
116MP0000343_altered_response_to0.40650273
117MP0005023_abnormal_wound_healing0.40484087
118MP0001986_abnormal_taste_sensitivity0.40339723
119MP0002693_abnormal_pancreas_physiology0.39997421
120MP0000371_diluted_coat_color0.39909440
121MP0009763_increased_sensitivity_to0.39743399
122MP0005164_abnormal_response_to0.38369177
123MP0005084_abnormal_gallbladder_morpholo0.38192178

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)8.55867799
2Gastrointestinal stroma tumor (HP:0100723)7.62124891
3Recurrent bronchitis (HP:0002837)7.09678155
4Recurrent sinusitis (HP:0011108)6.05748475
5IgM deficiency (HP:0002850)5.72780973
6Colitis (HP:0002583)5.48217629
7Cellulitis (HP:0100658)5.33397469
8Inflammation of the large intestine (HP:0002037)5.10287678
9Lymphopenia (HP:0001888)5.09746411
10Abnormal delayed hypersensitivity skin test (HP:0002963)5.09491103
11Papilloma (HP:0012740)4.90437566
12Verrucae (HP:0200043)4.90437566
13Gastrointestinal inflammation (HP:0004386)4.89298387
14Abnormality of cells of the lymphoid lineage (HP:0012140)4.87713033
15Emphysema (HP:0002097)4.82465563
16Chronic sinusitis (HP:0011109)4.75803296
17Panhypogammaglobulinemia (HP:0003139)4.68299794
18Recurrent viral infections (HP:0004429)4.64963937
19Chronic otitis media (HP:0000389)4.59788704
20Meningitis (HP:0001287)4.49268791
21Vasculitis (HP:0002633)4.30103383
22IgA deficiency (HP:0002720)4.29799582
23Abnormality of macrophages (HP:0004311)4.23105156
24Bronchitis (HP:0012387)4.11049561
25Orchitis (HP:0100796)4.09055433
26Chronic mucocutaneous candidiasis (HP:0002728)3.76442108
27Recurrent cutaneous fungal infections (HP:0011370)3.76442108
28T lymphocytopenia (HP:0005403)3.72463647
29Recurrent fungal infections (HP:0002841)3.72435023
30Gastrointestinal infarctions (HP:0005244)3.67243329
31Abnormality of T cell number (HP:0011839)3.64939109
32Restrictive lung disease (HP:0002091)3.61149813
33Recurrent otitis media (HP:0000403)3.52954445
34Recurrent lower respiratory tract infections (HP:0002783)3.51188991
35Abnormality of T cells (HP:0002843)3.50015866
36Recurrent pneumonia (HP:0006532)3.44963549
37Recurrent abscess formation (HP:0002722)3.44209831
38IgG deficiency (HP:0004315)3.42624623
39Osteomyelitis (HP:0002754)3.40725080
40Mediastinal lymphadenopathy (HP:0100721)3.31795633
41Recurrent bacterial skin infections (HP:0005406)3.25651971
42Chronic diarrhea (HP:0002028)3.24688895
43B lymphocytopenia (HP:0010976)3.20234371
44Abnormality of B cell number (HP:0010975)3.20234371
45Abnormality of the fingertips (HP:0001211)3.18907628
46Thyroiditis (HP:0100646)3.15368109
47Abnormality of T cell physiology (HP:0011840)3.14446618
48Nasal polyposis (HP:0100582)3.11717145
49Keratoconjunctivitis sicca (HP:0001097)3.07925637
50Eczematoid dermatitis (HP:0000976)3.07630701
51Lymphoma (HP:0002665)3.00465407
52Hemoptysis (HP:0002105)3.00329138
53Small epiphyses (HP:0010585)2.99557560
54Recurrent skin infections (HP:0001581)2.96952049
55Keratoconjunctivitis (HP:0001096)2.95833352
56Increased IgM level (HP:0003496)2.88969253
57Sepsis (HP:0100806)2.82065533
58Pulmonary infiltrates (HP:0002113)2.75892886
59Thrombocytosis (HP:0001894)2.74104296
60Leukopenia (HP:0001882)2.71896222
61Encephalitis (HP:0002383)2.71871507
62Viral hepatitis (HP:0006562)2.69817482
63Urticaria (HP:0001025)2.68419208
64Leukocytosis (HP:0001974)2.66385325
65Pustule (HP:0200039)2.64627672
66Autoimmune thrombocytopenia (HP:0001973)2.61971524
67Anorexia (HP:0002039)2.59784599
68Increased IgE level (HP:0003212)2.54716161
69Abnormality of the nasal mucosa (HP:0000433)2.51475060
70Obstructive lung disease (HP:0006536)2.51014216
71Chronic obstructive pulmonary disease (HP:0006510)2.51014216
72Abnormality of the pleura (HP:0002103)2.45534416
73Hypochromic anemia (HP:0001931)2.45409162
74Mitral stenosis (HP:0001718)2.44963769
75Spontaneous hematomas (HP:0007420)2.35806913
76Interstitial pulmonary disease (HP:0006530)2.29765521
77Stomach cancer (HP:0012126)2.28931509
78Gingivitis (HP:0000230)2.27925881
79Skin ulcer (HP:0200042)2.27630051
80Combined immunodeficiency (HP:0005387)2.27263833
81Skin rash (HP:0000988)2.26292327
82Xerostomia (HP:0000217)2.23947424
83Prolonged bleeding time (HP:0003010)2.23937872
84Pulmonary embolism (HP:0002204)2.22652310
85Stomatitis (HP:0010280)2.20358178
86Autoimmune hemolytic anemia (HP:0001890)2.19244841
87Vertebral arch anomaly (HP:0008438)2.18004942
88Gangrene (HP:0100758)2.17743178
89Myositis (HP:0100614)2.16666543
90Arthralgia (HP:0002829)2.15972820
91Elevated erythrocyte sedimentation rate (HP:0003565)2.12890589
92Hypergammaglobulinemia (HP:0010702)2.08399863
93Abnormality of the prostate (HP:0008775)2.07940649
94Increased density of long bones (HP:0006392)2.07866869
95Joint swelling (HP:0001386)2.07240711
96Severe combined immunodeficiency (HP:0004430)2.07181236
97Neutropenia (HP:0001875)2.06279917
98Basal cell carcinoma (HP:0002671)2.01894571
99Severe visual impairment (HP:0001141)2.01627531
100Epistaxis (HP:0000421)2.01456667
101Acrocyanosis (HP:0001063)2.01354651
102Hypochromic microcytic anemia (HP:0004840)1.99153987
103Petechiae (HP:0000967)1.96048933
104Premature loss of primary teeth (HP:0006323)1.94917140
105Albinism (HP:0001022)1.94811190
106Polyneuropathy (HP:0001271)1.94566278
107Abnormality of eosinophils (HP:0001879)1.92252421
108Villous atrophy (HP:0011473)1.92185767
109Abnormality of small intestinal villus morphology (HP:0011472)1.92185767
110Episodic fever (HP:0001954)1.91345494
111Eosinophilia (HP:0001880)1.89618651
112Hematochezia (HP:0002573)1.89017748
113Hypoplasia of the capital femoral epiphysis (HP:0003090)1.88797523
114Hepatitis (HP:0012115)1.87481492
115Flattened epiphyses (HP:0003071)1.86824418
116Chest pain (HP:0100749)1.86732233
117Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.84541071
118Fatigue (HP:0012378)1.82111782
119Bronchiectasis (HP:0002110)1.81585916
120Recurrent gram-negative bacterial infections (HP:0005420)1.78018477
121Reticulocytopenia (HP:0001896)1.72887198
122Granulocytopenia (HP:0001913)1.72797874
123Retrobulbar optic neuritis (HP:0100654)1.72206382
124Optic neuritis (HP:0100653)1.72206382
125Periodontitis (HP:0000704)1.72187277
126Pulmonary fibrosis (HP:0002206)1.71949259
127Papilledema (HP:0001085)1.69389021
128Arterial thrombosis (HP:0004420)1.69304281
129Irregular vertebral endplates (HP:0003301)1.68089408

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K17.43037537
2GRK63.36478217
3BLK2.74629905
4MAP3K142.70543649
5STK102.60578538
6CSF1R2.58544967
7SYK2.57294636
8BTK2.39821003
9JAK12.24980200
10MAP3K102.19648332
11MAP3K132.17315128
12LRRK22.15918580
13PRPF4B2.11744693
14TYK22.07770654
15MST42.00776166
16IRAK31.98207002
17RIPK41.93621350
18JAK31.93505347
19SIK21.90606177
20ERN11.85218838
21ITK1.82483441
22CDK121.72586741
23IKBKB1.58623464
24TBK11.53867007
25KIT1.51461416
26CSK1.50005421
27TEC1.49476955
28LYN1.47913661
29MARK31.46065978
30HCK1.43285709
31IKBKE1.42781139
32TXK1.42359243
33ZAP701.40090802
34SIK31.37977259
35IRAK41.36297618
36EEF2K1.34964137
37LCK1.33486151
38PRKCQ1.26694976
39FGFR41.26426262
40TAOK11.24391193
41CLK11.24179011
42FES1.23884878
43MAP3K111.19660190
44PIM11.17124055
45GRK11.14072646
46PRKCH1.12798592
47FGFR31.11975878
48MUSK1.11802866
49CHUK1.09391775
50TGFBR21.06281533
51NLK0.99625848
52BRD40.96038338
53RPS6KA40.94219332
54ALK0.90384059
55MAP3K30.89705264
56TNK20.82438618
57PASK0.79182357
58MAP2K20.78398832
59HIPK20.77880696
60EIF2AK30.75153929
61PRKD20.73079286
62SIK10.71848177
63EPHB10.70556378
64TAOK20.66908996
65EPHA30.62715862
66IRAK20.60340775
67MAP3K10.59774389
68MELK0.59359137
69MAPK70.58541521
70IRAK10.56677525
71MAPK110.56501354
72MATK0.55879241
73TAOK30.52861375
74INSR0.51857622
75MAPK150.51465736
76CDC42BPA0.51450816
77CDK90.51077044
78TLK10.50723320
79MAPK120.50688628
80MAP3K70.49110435
81PDK10.48366163
82ABL10.48273640
83YES10.47617927
84DYRK1B0.46872535
85FGR0.45943168
86CSNK1A1L0.44863365
87CDK40.44668522
88FYN0.43438218
89JAK20.40474813
90CDK190.40350869
91GRK70.38640660
92PDPK10.38153730
93RPS6KL10.35299863
94RPS6KC10.35299863
95MAP2K30.34865088
96PTK60.34436099
97RPS6KA60.33942167
98NUAK10.33712237
99ADRBK20.32506051
100PRKCD0.31625691
101ACVR1B0.30234782
102STK240.30233903
103EGFR0.30203361
104CSNK1G10.28946815
105BMPR20.28432820
106ARAF0.28286899
107NEK20.27811684
108CSNK1G30.27444458
109PRKD10.27219464
110CDK30.27064632
111SGK30.26928699
112STK40.26688392
113TRIB30.26578361
114STK110.25891702
115CAMKK10.24517115
116MARK20.24291977
117MAPK40.24084824
118CAMKK20.23221084
119PRKCI0.22082808
120MAPKAPK20.21347579
121MAP3K80.20984078
122MAPK30.20856019
123PKN10.20091060
124KDR0.18580797
125CAMK1G0.16814803
126TESK20.16683321
127NME20.16519219
128RPS6KA50.16087449

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053406.47451382
2B cell receptor signaling pathway_Homo sapiens_hsa046625.36705893
3NF-kappa B signaling pathway_Homo sapiens_hsa040643.22635253
4Intestinal immune network for IgA production_Homo sapiens_hsa046722.96087280
5Hematopoietic cell lineage_Homo sapiens_hsa046402.93579825
6T cell receptor signaling pathway_Homo sapiens_hsa046602.58730592
7Antigen processing and presentation_Homo sapiens_hsa046122.52651234
8Osteoclast differentiation_Homo sapiens_hsa043802.36674976
9Staphylococcus aureus infection_Homo sapiens_hsa051502.36608327
10Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.08702731
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.00920830
12Leishmaniasis_Homo sapiens_hsa051401.98803816
13Measles_Homo sapiens_hsa051621.97620835
14Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.89426220
15Ribosome_Homo sapiens_hsa030101.88750991
16Herpes simplex infection_Homo sapiens_hsa051681.66142791
17Rheumatoid arthritis_Homo sapiens_hsa053231.54172061
18Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.52312166
19Jak-STAT signaling pathway_Homo sapiens_hsa046301.46855669
20RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.41884586
21Epstein-Barr virus infection_Homo sapiens_hsa051691.40214240
22Base excision repair_Homo sapiens_hsa034101.37689983
23NOD-like receptor signaling pathway_Homo sapiens_hsa046211.37674856
24Toll-like receptor signaling pathway_Homo sapiens_hsa046201.35636492
25Leukocyte transendothelial migration_Homo sapiens_hsa046701.34852979
26* Chemokine signaling pathway_Homo sapiens_hsa040621.33125263
27Tuberculosis_Homo sapiens_hsa051521.24927922
28Hepatitis B_Homo sapiens_hsa051611.20393496
29Viral myocarditis_Homo sapiens_hsa054161.20063676
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.19945296
31Toxoplasmosis_Homo sapiens_hsa051451.18891531
32Shigellosis_Homo sapiens_hsa051311.13660614
33Influenza A_Homo sapiens_hsa051641.13163133
34Allograft rejection_Homo sapiens_hsa053301.12172742
35Acute myeloid leukemia_Homo sapiens_hsa052211.11451490
36Apoptosis_Homo sapiens_hsa042101.06053592
37Mismatch repair_Homo sapiens_hsa034301.01603190
38Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.00074387
39Platelet activation_Homo sapiens_hsa046110.99159793
40TNF signaling pathway_Homo sapiens_hsa046680.97885265
41Transcriptional misregulation in cancer_Homo sapiens_hsa052020.94978192
42HTLV-I infection_Homo sapiens_hsa051660.94397258
43Chronic myeloid leukemia_Homo sapiens_hsa052200.92230426
44Non-small cell lung cancer_Homo sapiens_hsa052230.89440790
45Neurotrophin signaling pathway_Homo sapiens_hsa047220.89427224
46Other glycan degradation_Homo sapiens_hsa005110.88759745
47Non-homologous end-joining_Homo sapiens_hsa034500.88754486
48Malaria_Homo sapiens_hsa051440.87818727
49Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.87802018
50AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.87798251
51Pancreatic cancer_Homo sapiens_hsa052120.86342553
52Graft-versus-host disease_Homo sapiens_hsa053320.83702347
53African trypanosomiasis_Homo sapiens_hsa051430.81258306
54* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.79713035
55Viral carcinogenesis_Homo sapiens_hsa052030.79476900
56Spliceosome_Homo sapiens_hsa030400.78529498
57Phagosome_Homo sapiens_hsa041450.76427997
58Hepatitis C_Homo sapiens_hsa051600.75794544
59VEGF signaling pathway_Homo sapiens_hsa043700.67910712
60MAPK signaling pathway_Homo sapiens_hsa040100.67375336
61Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65761019
62Autoimmune thyroid disease_Homo sapiens_hsa053200.65289519
63DNA replication_Homo sapiens_hsa030300.65234036
64Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61409996
65Small cell lung cancer_Homo sapiens_hsa052220.60455682
66Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.58946643
67Prolactin signaling pathway_Homo sapiens_hsa049170.57211363
68Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.56279855
69Legionellosis_Homo sapiens_hsa051340.56083389
70Pertussis_Homo sapiens_hsa051330.55526429
71Homologous recombination_Homo sapiens_hsa034400.54203526
72Notch signaling pathway_Homo sapiens_hsa043300.53987014
73Colorectal cancer_Homo sapiens_hsa052100.53520423
74Salmonella infection_Homo sapiens_hsa051320.52364768
75FoxO signaling pathway_Homo sapiens_hsa040680.50640846
76SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49703355
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.47322337
78Lysosome_Homo sapiens_hsa041420.46119707
79Endocytosis_Homo sapiens_hsa041440.45749321
80MicroRNAs in cancer_Homo sapiens_hsa052060.45108564
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44792285
82p53 signaling pathway_Homo sapiens_hsa041150.42789370
83Inositol phosphate metabolism_Homo sapiens_hsa005620.40064856
84Choline metabolism in cancer_Homo sapiens_hsa052310.40004766
85Glycerophospholipid metabolism_Homo sapiens_hsa005640.39584669
86RNA degradation_Homo sapiens_hsa030180.38833223
87Prostate cancer_Homo sapiens_hsa052150.37915869
88Lysine degradation_Homo sapiens_hsa003100.36900579
89Insulin resistance_Homo sapiens_hsa049310.36195298
90Regulation of autophagy_Homo sapiens_hsa041400.35784076
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.34943281
92Renal cell carcinoma_Homo sapiens_hsa052110.34724514
93Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33345598
94Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33129783
95mRNA surveillance pathway_Homo sapiens_hsa030150.33035228
96Proteoglycans in cancer_Homo sapiens_hsa052050.32600016
97Carbohydrate digestion and absorption_Homo sapiens_hsa049730.31855644
98Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.31178200
99Regulation of actin cytoskeleton_Homo sapiens_hsa048100.29815717
100Fanconi anemia pathway_Homo sapiens_hsa034600.29781542
101Dorso-ventral axis formation_Homo sapiens_hsa043200.29741569
102Type I diabetes mellitus_Homo sapiens_hsa049400.29217691
103Nucleotide excision repair_Homo sapiens_hsa034200.28898568
104Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.27909252
105Glycosaminoglycan degradation_Homo sapiens_hsa005310.27536158
106Pathways in cancer_Homo sapiens_hsa052000.27447844
107Asthma_Homo sapiens_hsa053100.26507197
108Phospholipase D signaling pathway_Homo sapiens_hsa040720.26093965
109Sphingolipid signaling pathway_Homo sapiens_hsa040710.24417683
110mTOR signaling pathway_Homo sapiens_hsa041500.24179093
111Thyroid hormone signaling pathway_Homo sapiens_hsa049190.23480196
112Adipocytokine signaling pathway_Homo sapiens_hsa049200.23379748
113HIF-1 signaling pathway_Homo sapiens_hsa040660.22974024
114Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.21527675
115Endometrial cancer_Homo sapiens_hsa052130.21325275
116Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.17564437
117alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.16825130
118Ether lipid metabolism_Homo sapiens_hsa005650.15395542
119GnRH signaling pathway_Homo sapiens_hsa049120.15184374
120Caffeine metabolism_Homo sapiens_hsa002320.13989999
121Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.13075082
122Arachidonic acid metabolism_Homo sapiens_hsa005900.13070709
123Ras signaling pathway_Homo sapiens_hsa040140.12233186
124Glycerolipid metabolism_Homo sapiens_hsa005610.12027491
125Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.10880755

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