ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.27723413
2	pyrimidine nucleobase catabolic process (GO:0006208)	4.37883018
3	L-fucose metabolic process (GO:0042354)	3.89879690
4	L-fucose catabolic process (GO:0042355)	3.89879690
5	fucose catabolic process (GO:0019317)	3.89879690
6	nucleobase catabolic process (GO:0046113)	3.84016882
7	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.82838384
8	water-soluble vitamin biosynthetic process (GO:0042364)	3.78400386
9	neural tube formation (GO:0001841)	3.71032029
10	response to pheromone (GO:0019236)	3.68823213
11	presynaptic membrane organization (GO:0097090)	3.49002848
12	nonmotile primary cilium assembly (GO:0035058)	3.32326923
13	olfactory bulb development (GO:0021772)	3.31725524
14	regulation of cilium movement (GO:0003352)	3.28924839
15	cornea development in camera-type eye (GO:0061303)	3.27222311
16	serotonin metabolic process (GO:0042428)	3.25378753
17	indolalkylamine metabolic process (GO:0006586)	3.23677340
18	presynaptic membrane assembly (GO:0097105)	3.15588487
19	kidney morphogenesis (GO:0060993)	3.12165546
20	limb bud formation (GO:0060174)	3.11150652
21	gamma-aminobutyric acid transport (GO:0015812)	3.09427295
22	primary amino compound metabolic process (GO:1901160)	3.07352876
23	establishment of protein localization to Golgi (GO:0072600)	3.04277092
24	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.98248387
25	detection of light stimulus involved in sensory perception (GO:0050962)	2.97364966
26	detection of light stimulus involved in visual perception (GO:0050908)	2.97364966
27	epithelial cilium movement (GO:0003351)	2.94757040
28	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.89403533
29	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.89403533
30	regulation of translation, ncRNA-mediated (GO:0045974)	2.89403533
31	neuronal action potential (GO:0019228)	2.89045507
32	cell proliferation in forebrain (GO:0021846)	2.87799724
33	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.83410242
34	single strand break repair (GO:0000012)	2.83004718
35	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	2.81891596
36	indole-containing compound metabolic process (GO:0042430)	2.78436515
37	tryptophan catabolic process (GO:0006569)	2.78238917
38	indole-containing compound catabolic process (GO:0042436)	2.78238917
39	indolalkylamine catabolic process (GO:0046218)	2.78238917
40	platelet dense granule organization (GO:0060155)	2.74643017
41	cilium organization (GO:0044782)	2.72319993
42	retinal cone cell development (GO:0046549)	2.72297137
43	cilium morphogenesis (GO:0060271)	2.71267944
44	startle response (GO:0001964)	2.69185249
45	head development (GO:0060322)	2.69007442
46	protein targeting to Golgi (GO:0000042)	2.68731100
47	regulation of action potential (GO:0098900)	2.68454750
48	intraciliary transport (GO:0042073)	2.68434598
49	cilium assembly (GO:0042384)	2.66794674
50	retinal ganglion cell axon guidance (GO:0031290)	2.65875229
51	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.65397109
52	protein localization to cilium (GO:0061512)	2.64984102
53	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.64511383
54	NADH dehydrogenase complex assembly (GO:0010257)	2.64511383
55	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.64511383
56	regulation of acrosome reaction (GO:0060046)	2.63336804
57	parturition (GO:0007567)	2.62342749
58	axonal fasciculation (GO:0007413)	2.62329696
59	inositol phosphate catabolic process (GO:0071545)	2.61902453
60	regulation of telomere maintenance (GO:0032204)	2.61566677
61	protein K11-linked deubiquitination (GO:0035871)	2.61171843
62	somite development (GO:0061053)	2.60118621
63	dopamine transport (GO:0015872)	2.59272205
64	behavioral response to ethanol (GO:0048149)	2.58466704
65	dendritic spine morphogenesis (GO:0060997)	2.57252089
66	piRNA metabolic process (GO:0034587)	2.55774537
67	protein localization to Golgi apparatus (GO:0034067)	2.55196292
68	cyclic nucleotide catabolic process (GO:0009214)	2.54426357
69	photoreceptor cell development (GO:0042461)	2.54307065
70	postsynaptic membrane organization (GO:0001941)	2.54108449
71	cAMP catabolic process (GO:0006198)	2.52813239
72	protein polyglutamylation (GO:0018095)	2.52450063
73	spinal cord development (GO:0021510)	2.51931608
74	kynurenine metabolic process (GO:0070189)	2.51680500
75	auditory behavior (GO:0031223)	2.51557508
76	glutamate receptor signaling pathway (GO:0007215)	2.51255613
77	cellular ketone body metabolic process (GO:0046950)	2.51110384
78	transmission of nerve impulse (GO:0019226)	2.50677580
79	photoreceptor cell maintenance (GO:0045494)	2.50575380
80	respiratory chain complex IV assembly (GO:0008535)	2.50051235
81	synaptic transmission, cholinergic (GO:0007271)	2.49581529
82	mechanosensory behavior (GO:0007638)	2.48873252
83	regulation of microtubule-based movement (GO:0060632)	2.48000316
84	polyol catabolic process (GO:0046174)	2.47617885
85	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.47223266
86	cilium movement (GO:0003341)	2.46520644
87	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.46295424
88	adaptation of signaling pathway (GO:0023058)	2.44193532
89	embryonic epithelial tube formation (GO:0001838)	2.43965956
90	protein complex biogenesis (GO:0070271)	2.43758296
91	DNA methylation involved in gamete generation (GO:0043046)	2.43628015
92	protein K6-linked ubiquitination (GO:0085020)	2.42515610
93	brain morphogenesis (GO:0048854)	2.42000613
94	axoneme assembly (GO:0035082)	2.41788569
95	tryptophan metabolic process (GO:0006568)	2.41326605
96	negative regulation of neurotransmitter transport (GO:0051589)	2.41294157
97	neuronal action potential propagation (GO:0019227)	2.40348124
98	reflex (GO:0060004)	2.39997781
99	ionotropic glutamate receptor signaling pathway (GO:0035235)	2.38265225
100	locomotory exploration behavior (GO:0035641)	2.38129489

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	3.51373144
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.25180021
3	ZNF274_21170338_ChIP-Seq_K562_Hela	2.90462474
4	VDR_22108803_ChIP-Seq_LS180_Human	2.87779444
5	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.57197976
6	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.44478060
7	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.42735889
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.42222003
9	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.37280604
10	IGF1R_20145208_ChIP-Seq_DFB_Human	2.36425468
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.31347783
12	TAF15_26573619_Chip-Seq_HEK293_Human	2.13943528
13	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.08997358
14	FUS_26573619_Chip-Seq_HEK293_Human	2.07252327
15	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.04776122
16	P300_19829295_ChIP-Seq_ESCs_Human	2.03929058
17	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.97039566
18	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.94864678
19	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.91308431
20	EWS_26573619_Chip-Seq_HEK293_Human	1.90317179
21	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.86241908
22	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.86092383
23	ER_23166858_ChIP-Seq_MCF-7_Human	1.79348791
24	SMAD4_21799915_ChIP-Seq_A2780_Human	1.78360812
25	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.75186203
26	STAT3_23295773_ChIP-Seq_U87_Human	1.63715396
27	BCAT_22108803_ChIP-Seq_LS180_Human	1.61836015
28	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.61705233
29	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.61147312
30	TCF4_23295773_ChIP-Seq_U87_Human	1.59158006
31	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.58910844
32	REST_21632747_ChIP-Seq_MESCs_Mouse	1.56171241
33	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.55613366
34	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.55150104
35	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.55040882
36	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.54468056
37	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.54468056
38	AR_25329375_ChIP-Seq_VCAP_Human	1.53671751
39	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.53578504
40	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.53338537
41	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.52083298
42	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.51048160
43	CBP_20019798_ChIP-Seq_JUKART_Human	1.47492431
44	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.47492431
45	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.46536860
46	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.45123135
47	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.45016305
48	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.44383635
49	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.40587959
50	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.39753009
51	RNF2_27304074_Chip-Seq_NSC_Mouse	1.39670969
52	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.38085144
53	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.35398846
54	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.35103535
55	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.34122749
56	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.33064667
57	* RUNX2_22187159_ChIP-Seq_PCA_Human	1.32743261
58	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.31356904
59	* TCF4_22108803_ChIP-Seq_LS180_Human	1.29848092
60	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.29016373
61	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.29000166
62	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.28616606
63	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.27162722
64	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.26703410
65	P53_22387025_ChIP-Seq_ESCs_Mouse	1.24172384
66	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.20283982
67	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.18633723
68	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.18132754
69	NANOG_19829295_ChIP-Seq_ESCs_Human	1.17376813
70	SOX2_19829295_ChIP-Seq_ESCs_Human	1.17376813
71	TP53_22573176_ChIP-Seq_HFKS_Human	1.17272063
72	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.17187873
73	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.16598669
74	IRF1_19129219_ChIP-ChIP_H3396_Human	1.16145386
75	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.15941573
76	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.15524014
77	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.14957672
78	AR_21572438_ChIP-Seq_LNCaP_Human	1.13938568
79	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.13813693
80	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.13559181
81	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.12489904
82	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.11966503
83	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.11256772
84	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.09106395
85	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.08917019
86	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.07043272
87	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.07010673
88	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.06379618
89	TP53_16413492_ChIP-PET_HCT116_Human	1.05644114
90	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.05512436
91	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.05471992
92	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.05107869
93	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.04822093
94	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.04652205
95	CDX2_22108803_ChIP-Seq_LS180_Human	1.01985599
96	P300_18555785_Chip-Seq_ESCs_Mouse	1.01854346
97	DROSHA_22980978_ChIP-Seq_HELA_Human	1.01381656
98	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	1.01066005
99	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.00930766
100	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.00449988

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003787_abnormal_imprinting	3.88122067
2	MP0000569_abnormal_digit_pigmentation	3.43894233
3	MP0006292_abnormal_olfactory_placode	2.98504856
4	MP0008877_abnormal_DNA_methylation	2.97685336
5	MP0005551_abnormal_eye_electrophysiolog	2.33626228
6	MP0002638_abnormal_pupillary_reflex	2.21124825
7	MP0003121_genomic_imprinting	2.19780027
8	MP0003890_abnormal_embryonic-extraembry	2.12534616
9	MP0002102_abnormal_ear_morphology	2.05994347
10	MP0003195_calcinosis	2.03959642
11	MP0001968_abnormal_touch/_nociception	2.00506258
12	MP0006276_abnormal_autonomic_nervous	1.99113263
13	MP0002837_dystrophic_cardiac_calcinosis	1.97799244
14	MP0009046_muscle_twitch	1.97260285
15	MP0000778_abnormal_nervous_system	1.92136262
16	MP0002272_abnormal_nervous_system	1.87988795
17	MP0003880_abnormal_central_pattern	1.86167381
18	MP0004142_abnormal_muscle_tone	1.84699943
19	MP0009745_abnormal_behavioral_response	1.82204941
20	MP0001984_abnormal_olfaction	1.82147681
21	MP0002736_abnormal_nociception_after	1.81567080
22	MP0006072_abnormal_retinal_apoptosis	1.78877002
23	MP0001986_abnormal_taste_sensitivity	1.76142339
24	MP0000631_abnormal_neuroendocrine_gland	1.68525721
25	MP0004133_heterotaxia	1.64382349
26	MP0004885_abnormal_endolymph	1.63752078
27	MP0005253_abnormal_eye_physiology	1.63551840
28	MP0001501_abnormal_sleep_pattern	1.61545258
29	MP0003122_maternal_imprinting	1.60919527
30	MP0001486_abnormal_startle_reflex	1.60902692
31	MP0002876_abnormal_thyroid_physiology	1.58396083
32	MP0002572_abnormal_emotion/affect_behav	1.56195550
33	MP0003635_abnormal_synaptic_transmissio	1.48502136
34	MP0000427_abnormal_hair_cycle	1.47892294
35	MP0002735_abnormal_chemical_nociception	1.46580932
36	MP0002938_white_spotting	1.45650291
37	MP0002557_abnormal_social/conspecific_i	1.44711116
38	MP0005386_behavior/neurological_phenoty	1.42759323
39	MP0004924_abnormal_behavior	1.42759323
40	MP0004145_abnormal_muscle_electrophysio	1.40642676
41	MP0005645_abnormal_hypothalamus_physiol	1.38501688
42	MP0001529_abnormal_vocalization	1.37900126
43	MP0002064_seizures	1.37550526
44	MP0005646_abnormal_pituitary_gland	1.37273617
45	MP0003646_muscle_fatigue	1.36528541
46	MP0002653_abnormal_ependyma_morphology	1.35788942
47	MP0008789_abnormal_olfactory_epithelium	1.35161074
48	MP0002751_abnormal_autonomic_nervous	1.35058369
49	MP0005423_abnormal_somatic_nervous	1.34496001
50	MP0002063_abnormal_learning/memory/cond	1.34449528
51	MP0003136_yellow_coat_color	1.34383814
52	MP0002928_abnormal_bile_duct	1.34297442
53	MP0001485_abnormal_pinna_reflex	1.33444683
54	MP0005174_abnormal_tail_pigmentation	1.32648030
55	MP0002067_abnormal_sensory_capabilities	1.29893853
56	MP0002909_abnormal_adrenal_gland	1.27637856
57	MP0002734_abnormal_mechanical_nocicepti	1.26644419
58	MP0004043_abnormal_pH_regulation	1.26238772
59	MP0005499_abnormal_olfactory_system	1.24734236
60	MP0005394_taste/olfaction_phenotype	1.24734236
61	MP0008872_abnormal_physiological_respon	1.23043987
62	MP0001970_abnormal_pain_threshold	1.22830330
63	MP0005075_abnormal_melanosome_morpholog	1.20825722
64	MP0002234_abnormal_pharynx_morphology	1.18556753
65	MP0003283_abnormal_digestive_organ	1.16636523
66	MP0004859_abnormal_synaptic_plasticity	1.15378422
67	MP0002733_abnormal_thermal_nociception	1.14510324
68	MP0005195_abnormal_posterior_eye	1.14097167
69	MP0002184_abnormal_innervation	1.14036451
70	MP0002752_abnormal_somatic_nervous	1.13834374
71	MP0004147_increased_porphyrin_level	1.13284651
72	MP0005084_abnormal_gallbladder_morpholo	1.11005444
73	MP0004270_analgesia	1.08588800
74	MP0002882_abnormal_neuron_morphology	1.07936394
75	MP0000372_irregular_coat_pigmentation	1.05297807
76	MP0002229_neurodegeneration	1.04898959
77	MP0002163_abnormal_gland_morphology	1.04724609
78	MP0000955_abnormal_spinal_cord	1.04594174
79	MP0003718_maternal_effect	1.04060905
80	MP0010386_abnormal_urinary_bladder	1.00725288
81	MP0008775_abnormal_heart_ventricle	0.98750929
82	MP0004215_abnormal_myocardial_fiber	0.94741864
83	MP0001502_abnormal_circadian_rhythm	0.91223892
84	MP0000230_abnormal_systemic_arterial	0.91013782
85	MP0002160_abnormal_reproductive_system	0.90617126
86	MP0001905_abnormal_dopamine_level	0.88769206
87	MP0005379_endocrine/exocrine_gland_phen	0.88248053
88	MP0000516_abnormal_urinary_system	0.84286406
89	MP0005367_renal/urinary_system_phenotyp	0.84286406
90	MP0001440_abnormal_grooming_behavior	0.83609924
91	MP0003011_delayed_dark_adaptation	0.80882535
92	MP0001324_abnormal_eye_pigmentation	0.78556246
93	MP0000049_abnormal_middle_ear	0.77926354
94	MP0005389_reproductive_system_phenotype	0.77347878
95	MP0000026_abnormal_inner_ear	0.76599988
96	MP0008995_early_reproductive_senescence	0.76568402
97	MP0001188_hyperpigmentation	0.76055235
98	MP0002693_abnormal_pancreas_physiology	0.76018607
99	MP0002152_abnormal_brain_morphology	0.75007908
100	MP0004085_abnormal_heartbeat	0.73901834

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.08885653
2	Hyperventilation (HP:0002883)	3.93643313
3	Pancreatic fibrosis (HP:0100732)	3.85494767
4	Abnormality of midbrain morphology (HP:0002418)	3.79900058
5	Molar tooth sign on MRI (HP:0002419)	3.79900058
6	Medial flaring of the eyebrow (HP:0010747)	3.75237847
7	Nephronophthisis (HP:0000090)	3.62775688
8	True hermaphroditism (HP:0010459)	3.54845806
9	Gait imbalance (HP:0002141)	3.30366682
10	Chronic hepatic failure (HP:0100626)	3.25742169
11	Abnormality of the renal medulla (HP:0100957)	3.25654554
12	Progressive cerebellar ataxia (HP:0002073)	3.15293363
13	Congenital primary aphakia (HP:0007707)	3.13440985
14	Congenital stationary night blindness (HP:0007642)	3.10443574
15	Type II lissencephaly (HP:0007260)	3.05445456
16	Abnormality of the renal cortex (HP:0011035)	3.05368480
17	Nephrogenic diabetes insipidus (HP:0009806)	2.92334215
18	Genital tract atresia (HP:0001827)	2.84308264
19	Broad-based gait (HP:0002136)	2.82041331
20	Vaginal atresia (HP:0000148)	2.74491670
21	Protruding tongue (HP:0010808)	2.71477326
22	Gaze-evoked nystagmus (HP:0000640)	2.69607450
23	Abnormal hair whorl (HP:0010721)	2.63342599
24	Cystic liver disease (HP:0006706)	2.54672097
25	Genetic anticipation (HP:0003743)	2.54248057
26	Abnormal rod and cone electroretinograms (HP:0008323)	2.49366790
27	Poor coordination (HP:0002370)	2.48724054
28	Oligodactyly (hands) (HP:0001180)	2.46741070
29	Absent speech (HP:0001344)	2.46369550
30	Volvulus (HP:0002580)	2.45914400
31	Fair hair (HP:0002286)	2.42564217
32	Abolished electroretinogram (ERG) (HP:0000550)	2.41835340
33	Drooling (HP:0002307)	2.41422007
34	Lissencephaly (HP:0001339)	2.40147905
35	Renal cortical cysts (HP:0000803)	2.40001267
36	Progressive inability to walk (HP:0002505)	2.37722899
37	Optic nerve hypoplasia (HP:0000609)	2.37497918
38	Attenuation of retinal blood vessels (HP:0007843)	2.36181626
39	Tubular atrophy (HP:0000092)	2.36007810
40	Febrile seizures (HP:0002373)	2.35190167
41	Inability to walk (HP:0002540)	2.33265989
42	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.32597253
43	Polydipsia (HP:0001959)	2.31638659
44	Abnormal drinking behavior (HP:0030082)	2.31638659
45	Pachygyria (HP:0001302)	2.29226092
46	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.24200379
47	Abnormality of alanine metabolism (HP:0010916)	2.24200379
48	Hyperalaninemia (HP:0003348)	2.24200379
49	Pendular nystagmus (HP:0012043)	2.22681587
50	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.21479080
51	Excessive salivation (HP:0003781)	2.20344167
52	Limb dystonia (HP:0002451)	2.19287724
53	Widely spaced teeth (HP:0000687)	2.17821600
54	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.15622403
55	Chorioretinal atrophy (HP:0000533)	2.15512044
56	Intestinal atresia (HP:0011100)	2.15096726
57	Abnormality of the labia minora (HP:0012880)	2.12789875
58	Hypothermia (HP:0002045)	2.12684204
59	Anencephaly (HP:0002323)	2.08762658
60	Abnormal pancreas size (HP:0012094)	2.07386270
61	Congenital hepatic fibrosis (HP:0002612)	2.05951043
62	Sclerocornea (HP:0000647)	2.05684130
63	Postaxial hand polydactyly (HP:0001162)	2.02421733
64	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.00208999
65	Absent/shortened dynein arms (HP:0200106)	2.00208999
66	Hepatoblastoma (HP:0002884)	1.97918712
67	Clumsiness (HP:0002312)	1.97851845
68	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.94479505
69	Decreased circulating renin level (HP:0003351)	1.93489169
70	Focal motor seizures (HP:0011153)	1.91843574
71	Retinal dysplasia (HP:0007973)	1.90713874
72	Neoplasm of the adrenal cortex (HP:0100641)	1.89577852
73	Keratoconus (HP:0000563)	1.88349357
74	Increased corneal curvature (HP:0100692)	1.88349357
75	Tubulointerstitial nephritis (HP:0001970)	1.87321083
76	Anterior segment dysgenesis (HP:0007700)	1.86946683
77	Generalized hypopigmentation of hair (HP:0011358)	1.86393286
78	Furrowed tongue (HP:0000221)	1.86387615
79	Focal seizures (HP:0007359)	1.84103491
80	Decreased central vision (HP:0007663)	1.83626722
81	Short foot (HP:0001773)	1.82027770
82	Specific learning disability (HP:0001328)	1.81113691
83	Dialeptic seizures (HP:0011146)	1.79375831
84	Bony spicule pigmentary retinopathy (HP:0007737)	1.79071332
85	Male pseudohermaphroditism (HP:0000037)	1.76820517
86	Congenital sensorineural hearing impairment (HP:0008527)	1.76719795
87	Agitation (HP:0000713)	1.75353556
88	Narrow forehead (HP:0000341)	1.74997411
89	Methylmalonic acidemia (HP:0002912)	1.74790900
90	Postaxial foot polydactyly (HP:0001830)	1.73324978
91	Cerebellar dysplasia (HP:0007033)	1.73194628
92	Polyuria (HP:0000103)	1.72960025
93	Hypoplastic labia majora (HP:0000059)	1.71863666
94	Growth hormone deficiency (HP:0000824)	1.70930367
95	Labial hypoplasia (HP:0000066)	1.70505689
96	Dandy-Walker malformation (HP:0001305)	1.69204268
97	Aqueductal stenosis (HP:0002410)	1.69066397
98	Abnormal biliary tract physiology (HP:0012439)	1.69045518
99	Bile duct proliferation (HP:0001408)	1.69045518
100	Left ventricular hypertrophy (HP:0001712)	1.67962501

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.26136273
2	BMPR1B	4.58026883
3	CASK	3.87719521
4	WNK3	3.07952216
5	ACVR1B	3.01943068
6	MAPK13	2.38025259
7	PINK1	2.16290853
8	TNIK	2.05195293
9	MARK1	2.04946217
10	ADRBK2	2.04052281
11	NUAK1	1.95983909
12	MAP4K2	1.95883894
13	MAP3K4	1.72130524
14	MKNK2	1.57663638
15	TAOK3	1.55004875
16	OXSR1	1.53095863
17	GRK1	1.51864827
18	NTRK3	1.46237967
19	IRAK1	1.45454920
20	FGFR2	1.44440052
21	PIK3CA	1.35314891
22	PAK3	1.27643971
23	ZAK	1.25899157
24	WNK4	1.22028435
25	TLK1	1.16215594
26	TRPM7	1.15238999
27	DYRK2	1.13617666
28	NTRK2	1.10927097
29	CSNK1G2	1.06932394
30	MARK3	1.06250814
31	SGK2	1.05429378
32	INSRR	1.04907538
33	STK39	1.03673626
34	MAP2K7	1.03478697
35	PRKCG	1.03414890
36	MAP3K9	1.03264894
37	AKT3	0.98211130
38	CSNK1G1	0.91110773
39	PRKCE	0.90642901
40	PHKG2	0.90581571
41	PHKG1	0.90581571
42	ERBB3	0.89758803
43	BCR	0.88140942
44	CSNK1G3	0.85767652
45	CDK19	0.85067982
46	SGK223	0.81779479
47	SGK494	0.81779479
48	SIK2	0.78047222
49	MINK1	0.76867472
50	PLK2	0.74872893
51	ADRBK1	0.74289451
52	STK38L	0.72584257
53	DAPK2	0.72313527
54	TGFBR1	0.70949423
55	EPHA4	0.70274709
56	STK11	0.68896311
57	MAPK15	0.68435791
58	PRKCZ	0.67045082
59	OBSCN	0.66734361
60	MAP2K4	0.66712775
61	TRIM28	0.66608772
62	MKNK1	0.66123796
63	CAMKK2	0.65159488
64	BRSK2	0.64342293
65	NLK	0.59684111
66	CSNK1A1L	0.58805187
67	TEC	0.58426633
68	PNCK	0.57995756
69	TNK2	0.56546010
70	CSNK1D	0.56510724
71	KIT	0.50725800
72	CAMK2A	0.50353087
73	TXK	0.49130075
74	PRKACA	0.48940593
75	STK3	0.48489517
76	YES1	0.47270203
77	CDK3	0.47100767
78	PIK3CG	0.46436749
79	PKN1	0.43713823
80	DYRK1A	0.43494825
81	MAP3K12	0.42791735
82	PRKAA1	0.41310817
83	PRKG1	0.41120206
84	NEK2	0.40522891
85	PTK2B	0.39658481
86	PASK	0.39194214
87	CSNK1A1	0.38692466
88	PRKACB	0.38229576
89	PRKCQ	0.38089900
90	MST4	0.37786672
91	PRKAA2	0.36800708
92	HIPK2	0.36189292
93	CDK5	0.35802788
94	TIE1	0.35437840
95	SGK3	0.34797700
96	SGK1	0.34225851
97	MAP2K6	0.33415981
98	CAMK1	0.33292209
99	ERBB2	0.32692410
100	CHUK	0.31993172

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	3.07914439
2	Phototransduction_Homo sapiens_hsa04744	2.94790387
3	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.61551493
4	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.51936582
5	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.46644811
6	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.17881416
7	Nitrogen metabolism_Homo sapiens_hsa00910	2.16927828
8	Butanoate metabolism_Homo sapiens_hsa00650	2.11343634
9	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.01691975
10	Linoleic acid metabolism_Homo sapiens_hsa00591	2.01011501
11	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.93058503
12	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.85817740
13	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.81613387
14	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.79504704
15	Caffeine metabolism_Homo sapiens_hsa00232	1.75142708
16	Selenocompound metabolism_Homo sapiens_hsa00450	1.65827806
17	Ether lipid metabolism_Homo sapiens_hsa00565	1.62082128
18	Morphine addiction_Homo sapiens_hsa05032	1.62050790
19	Basal transcription factors_Homo sapiens_hsa03022	1.53304409
20	Glutamatergic synapse_Homo sapiens_hsa04724	1.50985474
21	Olfactory transduction_Homo sapiens_hsa04740	1.50420618
22	Insulin secretion_Homo sapiens_hsa04911	1.50410675
23	Taste transduction_Homo sapiens_hsa04742	1.50000363
24	Protein export_Homo sapiens_hsa03060	1.49622942
25	ABC transporters_Homo sapiens_hsa02010	1.48703082
26	Circadian rhythm_Homo sapiens_hsa04710	1.47580352
27	Cocaine addiction_Homo sapiens_hsa05030	1.40181148
28	Circadian entrainment_Homo sapiens_hsa04713	1.40006688
29	Oxidative phosphorylation_Homo sapiens_hsa00190	1.39400385
30	Tryptophan metabolism_Homo sapiens_hsa00380	1.38344127
31	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.38337604
32	GABAergic synapse_Homo sapiens_hsa04727	1.36685972
33	Serotonergic synapse_Homo sapiens_hsa04726	1.34451849
34	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.32075061
35	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.31056779
36	Dopaminergic synapse_Homo sapiens_hsa04728	1.21764184
37	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.14625831
38	Amphetamine addiction_Homo sapiens_hsa05031	1.14080145
39	Collecting duct acid secretion_Homo sapiens_hsa04966	1.12074035
40	Fanconi anemia pathway_Homo sapiens_hsa03460	1.07945741
41	Propanoate metabolism_Homo sapiens_hsa00640	1.07623929
42	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.06674618
43	Long-term depression_Homo sapiens_hsa04730	1.05066106
44	Regulation of autophagy_Homo sapiens_hsa04140	1.03367107
45	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.01185428
46	Cardiac muscle contraction_Homo sapiens_hsa04260	1.00721875
47	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.99147562
48	Parkinsons disease_Homo sapiens_hsa05012	0.98486958
49	Peroxisome_Homo sapiens_hsa04146	0.97410828
50	Glycerolipid metabolism_Homo sapiens_hsa00561	0.90510597
51	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.90163914
52	RNA degradation_Homo sapiens_hsa03018	0.88063974
53	Homologous recombination_Homo sapiens_hsa03440	0.87641092
54	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.84660508
55	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.84443624
56	Axon guidance_Homo sapiens_hsa04360	0.82540043
57	RNA polymerase_Homo sapiens_hsa03020	0.81786641
58	Calcium signaling pathway_Homo sapiens_hsa04020	0.81570493
59	Cholinergic synapse_Homo sapiens_hsa04725	0.81115979
60	Salivary secretion_Homo sapiens_hsa04970	0.78431141
61	cAMP signaling pathway_Homo sapiens_hsa04024	0.78395955
62	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.78190439
63	Non-homologous end-joining_Homo sapiens_hsa03450	0.76881262
64	Chemical carcinogenesis_Homo sapiens_hsa05204	0.74931143
65	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.74685004
66	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.74029354
67	Retinol metabolism_Homo sapiens_hsa00830	0.73937197
68	Renin secretion_Homo sapiens_hsa04924	0.72626232
69	beta-Alanine metabolism_Homo sapiens_hsa00410	0.68297368
70	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.68099911
71	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.65438760
72	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.63318258
73	Type II diabetes mellitus_Homo sapiens_hsa04930	0.61435786
74	Mineral absorption_Homo sapiens_hsa04978	0.60777731
75	Huntingtons disease_Homo sapiens_hsa05016	0.60316341
76	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.59869052
77	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.58994686
78	Alzheimers disease_Homo sapiens_hsa05010	0.58454448
79	Steroid biosynthesis_Homo sapiens_hsa00100	0.58201914
80	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.57432141
81	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.53249607
82	Fat digestion and absorption_Homo sapiens_hsa04975	0.49762324
83	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.49587896
84	Sphingolipid metabolism_Homo sapiens_hsa00600	0.47900019
85	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.47864656
86	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.47665387
87	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.47222057
88	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.45842971
89	Basal cell carcinoma_Homo sapiens_hsa05217	0.43882034
90	Type I diabetes mellitus_Homo sapiens_hsa04940	0.43829572
91	Gastric acid secretion_Homo sapiens_hsa04971	0.43807667
92	Histidine metabolism_Homo sapiens_hsa00340	0.39927348
93	African trypanosomiasis_Homo sapiens_hsa05143	0.37541380
94	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.37265370
95	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.35988554
96	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.35289698
97	Ras signaling pathway_Homo sapiens_hsa04014	0.34806901
98	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.34282276
99	FoxO signaling pathway_Homo sapiens_hsa04068	0.34040181
100	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.33977798

CXORF23

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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