CXORF36

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1endothelium development (GO:0003158)9.81831981
2lymphangiogenesis (GO:0001946)7.24107915
3blood vessel maturation (GO:0001955)6.58723967
4positive regulation of vasculogenesis (GO:2001214)5.44218272
5retina vasculature morphogenesis in camera-type eye (GO:0061299)5.37575491
6angiogenesis involved in wound healing (GO:0060055)5.33707388
7vascular endothelial growth factor signaling pathway (GO:0038084)5.24159578
8regulation of vasculogenesis (GO:2001212)4.78720948
9lymph vessel development (GO:0001945)4.67162664
10sprouting angiogenesis (GO:0002040)4.53243012
11regulation of endothelial cell differentiation (GO:0045601)4.50926086
12cellular response to vascular endothelial growth factor stimulus (GO:0035924)4.42769431
13endothelial tube morphogenesis (GO:0061154)4.28542553
14morphogenesis of an endothelium (GO:0003159)4.28542553
15negative regulation of blood vessel endothelial cell migration (GO:0043537)4.27130447
16glomerular filtration (GO:0003094)4.02628136
17endothelial cell proliferation (GO:0001935)3.76104626
18regulation of sarcomere organization (GO:0060297)3.75841966
19regulation of establishment or maintenance of cell polarity (GO:0032878)3.69595801
20endothelial cell differentiation (GO:0045446)3.66572988
21positive regulation of endothelial cell differentiation (GO:0045603)3.61201705
22negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.55600907
23regulation of sequestering of triglyceride (GO:0010889)3.54845931
24regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.47113497
25negative regulation of endothelial cell migration (GO:0010596)3.44367311
26renal filtration (GO:0097205)3.41282409
27transcytosis (GO:0045056)3.36991503
28regulation of cell migration involved in sprouting angiogenesis (GO:0090049)3.35568932
29atrial cardiac muscle cell action potential (GO:0086014)3.30071429
30negative regulation of protein autophosphorylation (GO:0031953)3.15922552
31artery development (GO:0060840)3.11968975
32ovulation from ovarian follicle (GO:0001542)3.00287146
33nephron epithelium development (GO:0072009)2.94471858
34Notch signaling involved in heart development (GO:0061314)2.89291902
35patterning of blood vessels (GO:0001569)2.87507916
36positive regulation of protein kinase C signaling (GO:0090037)2.84967498
37heart valve formation (GO:0003188)2.84839752
38positive regulation of glomerulus development (GO:0090193)2.84443930
39vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.83420962
40arginine catabolic process (GO:0006527)2.75991521
41cAMP biosynthetic process (GO:0006171)2.72985534
42negative regulation of Rho protein signal transduction (GO:0035024)2.72542767
43negative regulation of calcium ion transport into cytosol (GO:0010523)2.64803357
44regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.64306046
45regulation of blood vessel endothelial cell migration (GO:0043535)2.60730195
46negative regulation of angiogenesis (GO:0016525)2.60205156
47positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.58523362
48negative regulation of epithelial cell migration (GO:0010633)2.56396553
49wound healing, spreading of epidermal cells (GO:0035313)2.55698937
50regulation of integrin-mediated signaling pathway (GO:2001044)2.55524817
51negative regulation of blood vessel morphogenesis (GO:2000181)2.54063569
52regulation of establishment of cell polarity (GO:2000114)2.53927122
53detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.52386347
54negative regulation of DNA biosynthetic process (GO:2000279)2.52109884
55triglyceride catabolic process (GO:0019433)2.51411593
56embryonic heart tube development (GO:0035050)2.47594965
57heparin biosynthetic process (GO:0030210)2.46388586
58heparin metabolic process (GO:0030202)2.46388586
59thrombin receptor signaling pathway (GO:0070493)2.45841576
60regulation of endothelial cell migration (GO:0010594)2.45735322
61negative regulation of platelet activation (GO:0010544)2.45719146
62regulation of vascular permeability (GO:0043114)2.45497390
63positive regulation of urine volume (GO:0035810)2.45356024
64ventricular trabecula myocardium morphogenesis (GO:0003222)2.44945239
65angiogenesis (GO:0001525)2.43939327
66negative regulation of vasculature development (GO:1901343)2.42494799
67phospholipid homeostasis (GO:0055091)2.42269424
68regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)2.42101881
69regulation of skeletal muscle contraction (GO:0014819)2.37723287
70positive regulation of focal adhesion assembly (GO:0051894)2.36957993
71positive regulation of cell junction assembly (GO:1901890)2.36957993
72definitive hemopoiesis (GO:0060216)2.36770272
73vasculogenesis (GO:0001570)2.35413016
74negative regulation of systemic arterial blood pressure (GO:0003085)2.32392545
75heart trabecula formation (GO:0060347)2.32129945
76bundle of His cell to Purkinje myocyte communication (GO:0086069)2.31515902
77cell migration involved in sprouting angiogenesis (GO:0002042)2.29948495
78protein K11-linked deubiquitination (GO:0035871)2.29425196
79myofibril assembly (GO:0030239)2.27840958
80growth hormone receptor signaling pathway (GO:0060396)2.27122210
81cAMP metabolic process (GO:0046058)2.26552932
82regulation of lipoprotein metabolic process (GO:0050746)2.23914166
83negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.23471128
84negative regulation of focal adhesion assembly (GO:0051895)2.21932481
85negative regulation of cell junction assembly (GO:1901889)2.21932481
86negative regulation of adherens junction organization (GO:1903392)2.21932481
87neuron remodeling (GO:0016322)2.20764408
88positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.20426955
89L-fucose catabolic process (GO:0042355)2.20297133
90fucose catabolic process (GO:0019317)2.20297133
91L-fucose metabolic process (GO:0042354)2.20297133
92negative regulation of endothelial cell apoptotic process (GO:2000352)2.19539297
93tachykinin receptor signaling pathway (GO:0007217)2.19007701
94negative regulation of cytosolic calcium ion concentration (GO:0051481)2.18293190
95regulation of synapse maturation (GO:0090128)2.17692934
96heart trabecula morphogenesis (GO:0061384)2.16607903
97membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.16570238
98tyrosine phosphorylation of STAT protein (GO:0007260)2.16408175
99signal peptide processing (GO:0006465)2.16214775
100regulation of cell-substrate junction assembly (GO:0090109)2.14887266

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.06307354
2* GATA2_21666600_ChIP-Seq_HMVEC_Human2.86585732
3VDR_22108803_ChIP-Seq_LS180_Human2.73198903
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.68906672
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.44765398
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.27226596
7CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.18437609
8CDX2_19796622_ChIP-Seq_MESCs_Mouse2.17463615
9ZNF274_21170338_ChIP-Seq_K562_Hela1.98906737
10IGF1R_20145208_ChIP-Seq_DFB_Human1.91465265
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.88100176
12SMAD_19615063_ChIP-ChIP_OVARY_Human1.81703241
13POU3F2_20337985_ChIP-ChIP_501MEL_Human1.81096453
14AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.79971548
15P300_19829295_ChIP-Seq_ESCs_Human1.74546647
16EZH2_22144423_ChIP-Seq_EOC_Human1.72751767
17BCAT_22108803_ChIP-Seq_LS180_Human1.62552731
18TAF15_26573619_Chip-Seq_HEK293_Human1.61231931
19* SMAD4_21799915_ChIP-Seq_A2780_Human1.59265765
20PIAS1_25552417_ChIP-Seq_VCAP_Human1.57659550
21PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.57011448
22SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.56742404
23RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.55439553
24DROSHA_22980978_ChIP-Seq_HELA_Human1.55035643
25ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.51981273
26AR_21572438_ChIP-Seq_LNCaP_Human1.51587086
27SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51306333
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.47332566
29TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46309928
30BP1_19119308_ChIP-ChIP_Hs578T_Human1.45723922
31EP300_21415370_ChIP-Seq_HL-1_Mouse1.45676487
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.44966413
33SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43262003
34ER_23166858_ChIP-Seq_MCF-7_Human1.41121392
35NR3C1_21868756_ChIP-Seq_MCF10A_Human1.40455684
36CJUN_26792858_Chip-Seq_BT549_Human1.40299469
37UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.39958347
38SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.39354107
39STAT3_23295773_ChIP-Seq_U87_Human1.38431014
40* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.38087134
41SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.36241219
42AR_25329375_ChIP-Seq_VCAP_Human1.35547482
43EED_16625203_ChIP-ChIP_MESCs_Mouse1.34261364
44SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32469390
45CTBP1_25329375_ChIP-Seq_LNCAP_Human1.31906593
46ZNF217_24962896_ChIP-Seq_MCF-7_Human1.30162642
47TCF4_23295773_ChIP-Seq_U87_Human1.28062659
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.26838440
49* TCF4_22108803_ChIP-Seq_LS180_Human1.26326892
50OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23207621
51CDX2_22108803_ChIP-Seq_LS180_Human1.19336592
52SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.17361970
53EZH2_27294783_Chip-Seq_NPCs_Mouse1.17271856
54EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.17015999
55FLI1_21867929_ChIP-Seq_TH2_Mouse1.16886242
56MTF2_20144788_ChIP-Seq_MESCs_Mouse1.15750425
57NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.15037588
58NRF2_20460467_ChIP-Seq_MEFs_Mouse1.15037588
59MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.14195578
60CBP_20019798_ChIP-Seq_JUKART_Human1.13927359
61IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.13927359
62EZH2_18974828_ChIP-Seq_MESCs_Mouse1.12958288
63RNF2_18974828_ChIP-Seq_MESCs_Mouse1.12958288
64MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.12052637
65AHR_22903824_ChIP-Seq_MCF-7_Human1.11774995
66SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.10946987
67SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10813403
68* RUNX2_22187159_ChIP-Seq_PCA_Human1.10590811
69LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.09874179
70PCGF2_27294783_Chip-Seq_ESCs_Mouse1.09198625
71TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09050634
72RXR_22108803_ChIP-Seq_LS180_Human1.08921589
73EZH2_27294783_Chip-Seq_ESCs_Mouse1.08539422
74SMAD3_21741376_ChIP-Seq_HESCs_Human1.08308319
75KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.07218993
76TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06549458
77SMAD4_21741376_ChIP-Seq_EPCs_Human1.05568523
78FUS_26573619_Chip-Seq_HEK293_Human1.05510602
79CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.04727703
80SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.03706187
81TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.03702005
82ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03358695
83NANOG_19829295_ChIP-Seq_ESCs_Human1.02702547
84SOX2_19829295_ChIP-Seq_ESCs_Human1.02702547
85SMAD4_21741376_ChIP-Seq_HESCs_Human1.02223127
86* EWS_26573619_Chip-Seq_HEK293_Human1.01294055
87FOXA1_21572438_ChIP-Seq_LNCaP_Human1.00907701
88NR3C1_23031785_ChIP-Seq_PC12_Mouse0.99956680
89ARNT_22903824_ChIP-Seq_MCF-7_Human0.99843007
90OCT4_21477851_ChIP-Seq_ESCs_Mouse0.99672153
91JARID2_20075857_ChIP-Seq_MESCs_Mouse0.98200172
92WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98159806
93KLF5_20875108_ChIP-Seq_MESCs_Mouse0.97624113
94KDM2B_26808549_Chip-Seq_REH_Human0.97602223
95EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.97144276
96CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.96795266
97ESR1_20079471_ChIP-ChIP_T-47D_Human0.96446269
98TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96343655
99FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96312048
100TP53_16413492_ChIP-PET_HCT116_Human0.95346965

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system7.82278119
2MP0001879_abnormal_lymphatic_vessel5.86366658
3MP0005167_abnormal_blood-brain_barrier5.37352710
4MP0005670_abnormal_white_adipose3.31058965
5MP0006054_spinal_hemorrhage3.30023002
6MP0002138_abnormal_hepatobiliary_system2.96254597
7MP0003724_increased_susceptibility_to2.91534900
8MP0004272_abnormal_basement_membrane2.88691952
9MP0004084_abnormal_cardiac_muscle2.61194069
10MP0006138_congestive_heart_failure2.48224494
11MP0004145_abnormal_muscle_electrophysio2.37786947
12MP0004215_abnormal_myocardial_fiber2.37208442
13MP0003828_pulmonary_edema2.35725231
14MP0003646_muscle_fatigue2.33896709
15MP0004484_altered_response_of2.17447468
16MP0003195_calcinosis2.16953082
17MP0000013_abnormal_adipose_tissue2.16390201
18MP0000465_gastrointestinal_hemorrhage2.06100416
19MP0004130_abnormal_muscle_cell2.04283878
20MP0000767_abnormal_smooth_muscle2.00941062
21MP0005595_abnormal_vascular_smooth1.94155424
22MP0004036_abnormal_muscle_relaxation1.89494744
23MP0003950_abnormal_plasma_membrane1.83389195
24MP0003279_aneurysm1.81479554
25MP0008775_abnormal_heart_ventricle1.59023230
26MP0002127_abnormal_cardiovascular_syste1.54703115
27MP0000751_myopathy1.51107776
28MP0001544_abnormal_cardiovascular_syste1.50157299
29MP0005385_cardiovascular_system_phenoty1.50157299
30MP0002933_joint_inflammation1.48716609
31MP0002332_abnormal_exercise_endurance1.47597452
32MP0004085_abnormal_heartbeat1.46951828
33MP0005165_increased_susceptibility_to1.46573245
34MP0005620_abnormal_muscle_contractility1.44116027
35MP0000003_abnormal_adipose_tissue1.38262151
36MP0000249_abnormal_blood_vessel1.38178604
37MP0002638_abnormal_pupillary_reflex1.37743816
38MP0003045_fibrosis1.37451948
39MP0002295_abnormal_pulmonary_circulatio1.35991631
40MP0002876_abnormal_thyroid_physiology1.33694328
41MP0002972_abnormal_cardiac_muscle1.29478638
42MP0005375_adipose_tissue_phenotype1.26895546
43MP0004885_abnormal_endolymph1.22151655
44MP0000749_muscle_degeneration1.21144052
45MP0006276_abnormal_autonomic_nervous1.20913724
46MP0003303_peritoneal_inflammation1.20291091
47MP0002837_dystrophic_cardiac_calcinosis1.18512320
48MP0002128_abnormal_blood_circulation1.17773355
49MP0000230_abnormal_systemic_arterial1.17416148
50MP0001501_abnormal_sleep_pattern1.16905019
51MP0004147_increased_porphyrin_level1.16560447
52MP0001614_abnormal_blood_vessel1.12917270
53MP0005551_abnormal_eye_electrophysiolog1.12720945
54MP0005084_abnormal_gallbladder_morpholo1.12254762
55MP0005330_cardiomyopathy1.02603555
56MP0002925_abnormal_cardiovascular_devel0.99603040
57MP0002108_abnormal_muscle_morphology0.98854715
58MP0002971_abnormal_brown_adipose0.98602670
59MP0005666_abnormal_adipose_tissue0.95722036
60MP0002106_abnormal_muscle_physiology0.95091433
61MP0002168_other_aberrant_phenotype0.93478970
62MP0003868_abnormal_feces_composition0.88248293
63MP0003137_abnormal_impulse_conducting0.87861526
64MP0005369_muscle_phenotype0.87737068
65MP0004782_abnormal_surfactant_physiolog0.87503591
66MP0010329_abnormal_lipoprotein_level0.86911895
67MP0004043_abnormal_pH_regulation0.85572532
68MP0005187_abnormal_penis_morphology0.78077850
69MP0003633_abnormal_nervous_system0.77044193
70MP0004087_abnormal_muscle_fiber0.75307317
71MP0009780_abnormal_chondrocyte_physiolo0.72471285
72MP0001486_abnormal_startle_reflex0.72137763
73MP0000266_abnormal_heart_morphology0.72005401
74MP0005253_abnormal_eye_physiology0.71916852
75MP0010630_abnormal_cardiac_muscle0.70828876
76MP0001784_abnormal_fluid_regulation0.70327128
77MP0003638_abnormal_response/metabolism_0.67109498
78MP0009115_abnormal_fat_cell0.65145427
79MP0005275_abnormal_skin_tensile0.58544903
80MP0003943_abnormal_hepatobiliary_system0.57439785
81MP0005535_abnormal_body_temperature0.57141032
82MP0005409_darkened_coat_color0.56091128
83MP0005266_abnormal_metabolism0.53837117
84MP0005503_abnormal_tendon_morphology0.50785810
85MP0000343_altered_response_to0.50440849
86MP0000759_abnormal_skeletal_muscle0.49888748
87MP0009046_muscle_twitch0.49491170
88MP0001915_intracranial_hemorrhage0.49120039
89MP0001968_abnormal_touch/_nociception0.46631197
90MP0003959_abnormal_lean_body0.46500768
91MP0003948_abnormal_gas_homeostasis0.46274181
92MP0005448_abnormal_energy_balance0.45941287
93MP0002118_abnormal_lipid_homeostasis0.45354957
94MP0005334_abnormal_fat_pad0.44400356
95MP0002970_abnormal_white_adipose0.43215674
96MP0003631_nervous_system_phenotype0.42813915
97MP0005195_abnormal_posterior_eye0.41944915
98MP0001485_abnormal_pinna_reflex0.41383713
99MP0000372_irregular_coat_pigmentation0.40030670
100MP0009745_abnormal_behavioral_response0.40026564

Predicted human phenotypes

RankGene SetZ-score
1Hematochezia (HP:0002573)5.18102411
2Muscle fiber splitting (HP:0003555)4.10713960
3Spontaneous hematomas (HP:0007420)3.74892230
4Cerebral hemorrhage (HP:0001342)3.69833537
5Lymphangioma (HP:0100764)3.67249098
6Adactyly (HP:0009776)3.54352764
7Portal hypertension (HP:0001409)3.51131590
8Nonimmune hydrops fetalis (HP:0001790)3.32371669
9Wrist flexion contracture (HP:0001239)3.29763585
10Esophageal varix (HP:0002040)3.28612895
11Difficulty running (HP:0009046)3.17346514
12Polycythemia (HP:0001901)3.15087679
13Hyporeflexia of lower limbs (HP:0002600)3.14181863
14Abnormality of the hepatic vasculature (HP:0006707)3.10822469
15Attenuation of retinal blood vessels (HP:0007843)3.00778064
16Atrial fibrillation (HP:0005110)3.00190184
17Heart block (HP:0012722)2.94722287
18Skull defect (HP:0001362)2.92067314
19Congenital stationary night blindness (HP:0007642)2.91591056
20Hyperventilation (HP:0002883)2.90977987
21Scotoma (HP:0000575)2.87486114
22Supraventricular arrhythmia (HP:0005115)2.84257060
23Myotonia (HP:0002486)2.82103254
24Pancreatic cysts (HP:0001737)2.77874539
25Primary atrial arrhythmia (HP:0001692)2.77348454
26Atrioventricular block (HP:0001678)2.77270602
27Decreased circulating renin level (HP:0003351)2.74131365
28Bulbous nose (HP:0000414)2.71696280
29Abnormal atrioventricular conduction (HP:0005150)2.62969469
30Keratoconus (HP:0000563)2.62944240
31Increased corneal curvature (HP:0100692)2.62944240
32Pigmentary retinal degeneration (HP:0001146)2.62617438
33Supraventricular tachycardia (HP:0004755)2.58480112
34Bundle branch block (HP:0011710)2.55625036
35Cerebral aneurysm (HP:0004944)2.52937599
36Calf muscle hypertrophy (HP:0008981)2.51897407
37Abnormality of macular pigmentation (HP:0008002)2.50027645
38Areflexia of lower limbs (HP:0002522)2.48515372
39Muscle hypertrophy of the lower extremities (HP:0008968)2.46865189
40Conjunctival telangiectasia (HP:0000524)2.46155141
41Muscle fiber inclusion bodies (HP:0100299)2.45864319
42Myocardial infarction (HP:0001658)2.45255902
43Hyperlipoproteinemia (HP:0010980)2.43947968
44Visceral angiomatosis (HP:0100761)2.41574165
45Facial diplegia (HP:0001349)2.40876028
46Nemaline bodies (HP:0003798)2.39623231
47Prolonged QT interval (HP:0001657)2.38313076
48Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.36113315
49Oligomenorrhea (HP:0000876)2.35247474
50Hemiplegia (HP:0002301)2.33227725
51Absent hand (HP:0004050)2.27088344
52Abnormality of the renal cortex (HP:0011035)2.24822303
53True hermaphroditism (HP:0010459)2.24691962
54Syncope (HP:0001279)2.21277980
55Central scotoma (HP:0000603)2.21226267
56Congenital sensorineural hearing impairment (HP:0008527)2.19721293
57Pancreatic fibrosis (HP:0100732)2.18826386
58Decreased central vision (HP:0007663)2.16630970
59Distal arthrogryposis (HP:0005684)2.16422539
60Hemiparesis (HP:0001269)2.14924236
61Hemangiomatosis (HP:0007461)2.14235164
62Congenital hepatic fibrosis (HP:0002612)2.13396207
63Aortic aneurysm (HP:0004942)2.13166498
64Aplasia/Hypoplasia of the tibia (HP:0005772)2.13117266
65Abnormality of the calf musculature (HP:0001430)2.11926189
66Polydipsia (HP:0001959)2.10441668
67Abnormal drinking behavior (HP:0030082)2.10441668
68Inability to walk (HP:0002540)2.08601772
69Aortic valve stenosis (HP:0001650)2.08509666
70Molar tooth sign on MRI (HP:0002419)2.06420333
71Abnormality of midbrain morphology (HP:0002418)2.06420333
72Hip contracture (HP:0003273)2.05065213
73Sudden death (HP:0001699)2.03854118
74Hyperkalemia (HP:0002153)2.03549347
75Broad-based gait (HP:0002136)2.03536708
76Congenital, generalized hypertrichosis (HP:0004540)2.02849781
77Abnormality of the renal medulla (HP:0100957)2.02186435
78Exotropia (HP:0000577)2.01540454
79Occipital encephalocele (HP:0002085)2.01106348
80Increased variability in muscle fiber diameter (HP:0003557)2.00935641
81Bony spicule pigmentary retinopathy (HP:0007737)1.97227031
82Delayed CNS myelination (HP:0002188)1.96473033
83Type 1 muscle fiber predominance (HP:0003803)1.94500514
84Nephronophthisis (HP:0000090)1.94372938
85Tubular atrophy (HP:0000092)1.94109579
86Cystic liver disease (HP:0006706)1.91695556
87Abnormality of skeletal muscle fiber size (HP:0012084)1.91509058
88EMG: myopathic abnormalities (HP:0003458)1.90996775
89Asymmetric septal hypertrophy (HP:0001670)1.89680960
90Prominent supraorbital ridges (HP:0000336)1.88782589
91Abnormality of the ischium (HP:0003174)1.88466418
92Type II lissencephaly (HP:0007260)1.87179068
93Abolished electroretinogram (ERG) (HP:0000550)1.84520138
94Febrile seizures (HP:0002373)1.82833719
95Porencephaly (HP:0002132)1.82513943
96Lipoatrophy (HP:0100578)1.81608878
97Chronic hepatic failure (HP:0100626)1.81249400
98Abnormal EKG (HP:0003115)1.79581924
99Large for gestational age (HP:0001520)1.78458726
100Arterial tortuosity (HP:0005116)1.78171352

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR4.33991341
2FRK4.17069068
3TGFBR22.61577668
4FER2.52638773
5BMPR1B2.18731091
6TIE111.5063444
7GRK11.86709258
8TGFBR11.85338044
9EPHB21.82936044
10FES1.75150942
11OBSCN1.67613246
12TEC1.52866080
13PTK2B1.51540152
14INSRR1.34618153
15PINK11.27935153
16ACVR1B1.26486916
17MAPKAPK31.23141164
18MYLK1.18293908
19ADRBK21.15463695
20WNK31.15083259
21MAPK131.12141753
22PRKAA21.10478945
23PHKG10.96806023
24PHKG20.96806023
25EPHA30.95810385
26STK38L0.94238842
27TRPM70.91775237
28NLK0.90732000
29DAPK20.89994426
30MAP4K20.87218250
31NUAK10.84512957
32GRK50.78099267
33NTRK30.76360446
34ADRBK10.74817027
35STK390.72530333
36PIK3CG0.71807617
37MAP3K70.71117302
38PAK30.69936559
39LATS10.68326081
40MAPK120.62044688
41PRKG20.61445255
42PRKCE0.60785317
43RIPK10.60271194
44MAPKAPK50.58636165
45OXSR10.57432330
46TAOK30.57195104
47IRAK10.56730156
48PKN10.56674382
49KIT0.56102826
50CAMK10.54831664
51FLT30.54258605
52ROCK10.53632565
53PIK3CA0.52970506
54PRKD10.51559520
55IGF1R0.46451744
56CSK0.45342469
57TTN0.42662943
58TXK0.41695470
59PRKAA10.41293448
60MARK10.41165467
61CAMK2A0.40730250
62STK380.40061210
63MAPK150.39076722
64FGFR20.38855064
65EPHB10.37797304
66PRKD30.37723476
67ITK0.37423735
68SGK20.35983510
69MAPK70.34898116
70PRKG10.33734802
71PDK20.32366001
72MET0.30222365
73PTK20.30203102
74MAP2K10.29900493
75CASK0.29774107
76TNIK0.28604659
77CSNK1G10.27618412
78AKT30.25506247
79MAPK40.25256782
80EEF2K0.25000362
81ZAP700.23641761
82PLK20.22912156
83MKNK20.22560640
84PRKACA0.22410058
85TNK20.22275024
86HCK0.21935993
87CDC42BPA0.21284150
88CAMK40.21146649
89STK110.20968004
90EGFR0.20543098
91NTRK10.20465022
92BCR0.20430002
93PDGFRB0.20255225
94GSK3A0.19694405
95MAP2K60.19002488
96MUSK0.18141510
97ABL10.16511265
98CAMKK20.16487763
99ZAK0.16043182
100ROCK20.15772757

Predicted pathways (KEGG)

RankGene SetZ-score
1Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.28596901
2Tryptophan metabolism_Homo sapiens_hsa003802.11831694
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.11134703
4Dorso-ventral axis formation_Homo sapiens_hsa043201.98686242
5Linoleic acid metabolism_Homo sapiens_hsa005911.95343439
6ABC transporters_Homo sapiens_hsa020101.94415701
7Butanoate metabolism_Homo sapiens_hsa006501.93452626
8Glycosaminoglycan degradation_Homo sapiens_hsa005311.92845103
9Vascular smooth muscle contraction_Homo sapiens_hsa042701.89201892
10Phototransduction_Homo sapiens_hsa047441.85916704
11Nitrogen metabolism_Homo sapiens_hsa009101.80246530
12Ovarian steroidogenesis_Homo sapiens_hsa049131.76510118
13ECM-receptor interaction_Homo sapiens_hsa045121.76272056
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.74477628
15Glycerolipid metabolism_Homo sapiens_hsa005611.67481699
16PPAR signaling pathway_Homo sapiens_hsa033201.61712580
17Dilated cardiomyopathy_Homo sapiens_hsa054141.61068490
18Morphine addiction_Homo sapiens_hsa050321.56031619
19Histidine metabolism_Homo sapiens_hsa003401.55916986
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.51621340
21Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.50109793
22Renin secretion_Homo sapiens_hsa049241.48201526
23Fatty acid degradation_Homo sapiens_hsa000711.47236572
24Ether lipid metabolism_Homo sapiens_hsa005651.45342729
25Propanoate metabolism_Homo sapiens_hsa006401.40732163
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.40406687
27Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.34152236
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.26897918
29Circadian entrainment_Homo sapiens_hsa047131.26605770
30Focal adhesion_Homo sapiens_hsa045101.25398183
31Calcium signaling pathway_Homo sapiens_hsa040201.24482605
32Complement and coagulation cascades_Homo sapiens_hsa046101.24252800
33beta-Alanine metabolism_Homo sapiens_hsa004101.24124579
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.23132432
35Serotonergic synapse_Homo sapiens_hsa047261.21649578
36Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.21505693
37Salivary secretion_Homo sapiens_hsa049701.16988298
38Ras signaling pathway_Homo sapiens_hsa040141.11735356
39Glutamatergic synapse_Homo sapiens_hsa047241.10874261
40Taste transduction_Homo sapiens_hsa047421.06326446
41Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.06098755
42Oxytocin signaling pathway_Homo sapiens_hsa049211.05239226
43Rap1 signaling pathway_Homo sapiens_hsa040151.05237494
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.04495405
45cAMP signaling pathway_Homo sapiens_hsa040241.03312475
46Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.03134145
47Arachidonic acid metabolism_Homo sapiens_hsa005901.03045926
48cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99448843
49Platelet activation_Homo sapiens_hsa046110.97752559
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.97502016
51Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.96253626
52GABAergic synapse_Homo sapiens_hsa047270.96207440
53Insulin secretion_Homo sapiens_hsa049110.96020568
54Aldosterone synthesis and secretion_Homo sapiens_hsa049250.95778571
55Nicotine addiction_Homo sapiens_hsa050330.94380483
56Circadian rhythm_Homo sapiens_hsa047100.93485328
57Olfactory transduction_Homo sapiens_hsa047400.93201693
58Fatty acid metabolism_Homo sapiens_hsa012120.91915234
59Gastric acid secretion_Homo sapiens_hsa049710.91791989
60Leukocyte transendothelial migration_Homo sapiens_hsa046700.89258800
61Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.88705966
62Fat digestion and absorption_Homo sapiens_hsa049750.87942071
63Tight junction_Homo sapiens_hsa045300.87852341
64Glycerophospholipid metabolism_Homo sapiens_hsa005640.87204038
65Regulation of autophagy_Homo sapiens_hsa041400.86719016
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.79578476
67Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78952178
68Primary bile acid biosynthesis_Homo sapiens_hsa001200.78854678
69Axon guidance_Homo sapiens_hsa043600.78437531
70Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.78258778
71Steroid hormone biosynthesis_Homo sapiens_hsa001400.74968272
72PI3K-Akt signaling pathway_Homo sapiens_hsa041510.72462360
73Phospholipase D signaling pathway_Homo sapiens_hsa040720.71136671
74Selenocompound metabolism_Homo sapiens_hsa004500.70657090
75Retinol metabolism_Homo sapiens_hsa008300.70017667
76Maturity onset diabetes of the young_Homo sapiens_hsa049500.69698001
77Bile secretion_Homo sapiens_hsa049760.68115714
78Protein digestion and absorption_Homo sapiens_hsa049740.67608883
79Chemical carcinogenesis_Homo sapiens_hsa052040.65177075
80Peroxisome_Homo sapiens_hsa041460.64839686
81Fatty acid biosynthesis_Homo sapiens_hsa000610.64094018
82Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.62778810
83Adherens junction_Homo sapiens_hsa045200.60704991
84Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.60471829
85Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60351802
86Arginine and proline metabolism_Homo sapiens_hsa003300.60049027
87Pancreatic secretion_Homo sapiens_hsa049720.59877279
88Lysine degradation_Homo sapiens_hsa003100.56398148
89Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.53975189
90Cholinergic synapse_Homo sapiens_hsa047250.52489609
91Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.50472940
92Long-term depression_Homo sapiens_hsa047300.48993252
93Arginine biosynthesis_Homo sapiens_hsa002200.47049387
94Vitamin digestion and absorption_Homo sapiens_hsa049770.45967857
95Tyrosine metabolism_Homo sapiens_hsa003500.44873713
96Sulfur metabolism_Homo sapiens_hsa009200.44256871
97TGF-beta signaling pathway_Homo sapiens_hsa043500.44033984
98Renin-angiotensin system_Homo sapiens_hsa046140.43726932
99Cardiac muscle contraction_Homo sapiens_hsa042600.43386179
100Insulin resistance_Homo sapiens_hsa049310.41218805

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