ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	endothelium development (GO:0003158)	9.81831981
2	lymphangiogenesis (GO:0001946)	7.24107915
3	blood vessel maturation (GO:0001955)	6.58723967
4	positive regulation of vasculogenesis (GO:2001214)	5.44218272
5	retina vasculature morphogenesis in camera-type eye (GO:0061299)	5.37575491
6	angiogenesis involved in wound healing (GO:0060055)	5.33707388
7	vascular endothelial growth factor signaling pathway (GO:0038084)	5.24159578
8	regulation of vasculogenesis (GO:2001212)	4.78720948
9	lymph vessel development (GO:0001945)	4.67162664
10	sprouting angiogenesis (GO:0002040)	4.53243012
11	regulation of endothelial cell differentiation (GO:0045601)	4.50926086
12	cellular response to vascular endothelial growth factor stimulus (GO:0035924)	4.42769431
13	morphogenesis of an endothelium (GO:0003159)	4.28542553
14	endothelial tube morphogenesis (GO:0061154)	4.28542553
15	negative regulation of blood vessel endothelial cell migration (GO:0043537)	4.27130447
16	glomerular filtration (GO:0003094)	4.02628136
17	endothelial cell proliferation (GO:0001935)	3.76104626
18	regulation of sarcomere organization (GO:0060297)	3.75841966
19	regulation of establishment or maintenance of cell polarity (GO:0032878)	3.69595801
20	endothelial cell differentiation (GO:0045446)	3.66572988
21	positive regulation of endothelial cell differentiation (GO:0045603)	3.61201705
22	negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)	3.55600907
23	regulation of sequestering of triglyceride (GO:0010889)	3.54845931
24	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	3.47113497
25	negative regulation of endothelial cell migration (GO:0010596)	3.44367311
26	renal filtration (GO:0097205)	3.41282409
27	transcytosis (GO:0045056)	3.36991503
28	regulation of cell migration involved in sprouting angiogenesis (GO:0090049)	3.35568932
29	atrial cardiac muscle cell action potential (GO:0086014)	3.30071429
30	negative regulation of protein autophosphorylation (GO:0031953)	3.15922552
31	artery development (GO:0060840)	3.11968975
32	ovulation from ovarian follicle (GO:0001542)	3.00287146
33	nephron epithelium development (GO:0072009)	2.94471858
34	Notch signaling involved in heart development (GO:0061314)	2.89291902
35	patterning of blood vessels (GO:0001569)	2.87507916
36	positive regulation of protein kinase C signaling (GO:0090037)	2.84967498
37	heart valve formation (GO:0003188)	2.84839752
38	positive regulation of glomerulus development (GO:0090193)	2.84443930
39	vascular endothelial growth factor receptor signaling pathway (GO:0048010)	2.83420962
40	arginine catabolic process (GO:0006527)	2.75991521
41	cAMP biosynthetic process (GO:0006171)	2.72985534
42	negative regulation of Rho protein signal transduction (GO:0035024)	2.72542767
43	negative regulation of calcium ion transport into cytosol (GO:0010523)	2.64803357
44	regulation of calcineurin-NFAT signaling cascade (GO:0070884)	2.64306046
45	regulation of blood vessel endothelial cell migration (GO:0043535)	2.60730195
46	negative regulation of angiogenesis (GO:0016525)	2.60205156
47	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	2.58523362
48	negative regulation of epithelial cell migration (GO:0010633)	2.56396553
49	wound healing, spreading of epidermal cells (GO:0035313)	2.55698937
50	regulation of integrin-mediated signaling pathway (GO:2001044)	2.55524817
51	negative regulation of blood vessel morphogenesis (GO:2000181)	2.54063569
52	regulation of establishment of cell polarity (GO:2000114)	2.53927122
53	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.52386347
54	negative regulation of DNA biosynthetic process (GO:2000279)	2.52109884
55	triglyceride catabolic process (GO:0019433)	2.51411593
56	embryonic heart tube development (GO:0035050)	2.47594965
57	heparin biosynthetic process (GO:0030210)	2.46388586
58	heparin metabolic process (GO:0030202)	2.46388586
59	thrombin receptor signaling pathway (GO:0070493)	2.45841576
60	regulation of endothelial cell migration (GO:0010594)	2.45735322
61	negative regulation of platelet activation (GO:0010544)	2.45719146
62	regulation of vascular permeability (GO:0043114)	2.45497390
63	positive regulation of urine volume (GO:0035810)	2.45356024
64	ventricular trabecula myocardium morphogenesis (GO:0003222)	2.44945239
65	angiogenesis (GO:0001525)	2.43939327
66	negative regulation of vasculature development (GO:1901343)	2.42494799
67	phospholipid homeostasis (GO:0055091)	2.42269424
68	regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)	2.42101881
69	regulation of skeletal muscle contraction (GO:0014819)	2.37723287
70	positive regulation of focal adhesion assembly (GO:0051894)	2.36957993
71	positive regulation of cell junction assembly (GO:1901890)	2.36957993
72	definitive hemopoiesis (GO:0060216)	2.36770272
73	vasculogenesis (GO:0001570)	2.35413016
74	negative regulation of systemic arterial blood pressure (GO:0003085)	2.32392545
75	heart trabecula formation (GO:0060347)	2.32129945
76	bundle of His cell to Purkinje myocyte communication (GO:0086069)	2.31515902
77	cell migration involved in sprouting angiogenesis (GO:0002042)	2.29948495
78	protein K11-linked deubiquitination (GO:0035871)	2.29425196
79	myofibril assembly (GO:0030239)	2.27840958
80	growth hormone receptor signaling pathway (GO:0060396)	2.27122210
81	cAMP metabolic process (GO:0046058)	2.26552932
82	regulation of lipoprotein metabolic process (GO:0050746)	2.23914166
83	negative regulation of macrophage derived foam cell differentiation (GO:0010745)	2.23471128
84	negative regulation of focal adhesion assembly (GO:0051895)	2.21932481
85	negative regulation of cell junction assembly (GO:1901889)	2.21932481
86	negative regulation of adherens junction organization (GO:1903392)	2.21932481
87	neuron remodeling (GO:0016322)	2.20764408
88	positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)	2.20426955
89	L-fucose catabolic process (GO:0042355)	2.20297133
90	fucose catabolic process (GO:0019317)	2.20297133
91	L-fucose metabolic process (GO:0042354)	2.20297133
92	negative regulation of endothelial cell apoptotic process (GO:2000352)	2.19539297
93	tachykinin receptor signaling pathway (GO:0007217)	2.19007701
94	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.18293190
95	regulation of synapse maturation (GO:0090128)	2.17692934
96	heart trabecula morphogenesis (GO:0061384)	2.16607903
97	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.16570238
98	tyrosine phosphorylation of STAT protein (GO:0007260)	2.16408175
99	signal peptide processing (GO:0006465)	2.16214775
100	regulation of cell-substrate junction assembly (GO:0090109)	2.14887266

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.06307354
2	* GATA2_21666600_ChIP-Seq_HMVEC_Human	2.86585732
3	VDR_22108803_ChIP-Seq_LS180_Human	2.73198903
4	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.68906672
5	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.44765398
6	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.27226596
7	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.18437609
8	CDX2_19796622_ChIP-Seq_MESCs_Mouse	2.17463615
9	ZNF274_21170338_ChIP-Seq_K562_Hela	1.98906737
10	IGF1R_20145208_ChIP-Seq_DFB_Human	1.91465265
11	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.88100176
12	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.81703241
13	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.81096453
14	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.79971548
15	P300_19829295_ChIP-Seq_ESCs_Human	1.74546647
16	EZH2_22144423_ChIP-Seq_EOC_Human	1.72751767
17	BCAT_22108803_ChIP-Seq_LS180_Human	1.62552731
18	TAF15_26573619_Chip-Seq_HEK293_Human	1.61231931
19	* SMAD4_21799915_ChIP-Seq_A2780_Human	1.59265765
20	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.57659550
21	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.57011448
22	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.56742404
23	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.55439553
24	DROSHA_22980978_ChIP-Seq_HELA_Human	1.55035643
25	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.51981273
26	AR_21572438_ChIP-Seq_LNCaP_Human	1.51587086
27	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.51306333
28	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.47332566
29	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.46309928
30	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.45723922
31	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.45676487
32	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.44966413
33	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.43262003
34	ER_23166858_ChIP-Seq_MCF-7_Human	1.41121392
35	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.40455684
36	CJUN_26792858_Chip-Seq_BT549_Human	1.40299469
37	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.39958347
38	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.39354107
39	STAT3_23295773_ChIP-Seq_U87_Human	1.38431014
40	* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.38087134
41	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.36241219
42	AR_25329375_ChIP-Seq_VCAP_Human	1.35547482
43	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.34261364
44	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.32469390
45	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.31906593
46	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.30162642
47	TCF4_23295773_ChIP-Seq_U87_Human	1.28062659
48	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.26838440
49	* TCF4_22108803_ChIP-Seq_LS180_Human	1.26326892
50	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.23207621
51	CDX2_22108803_ChIP-Seq_LS180_Human	1.19336592
52	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.17361970
53	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.17271856
54	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.17015999
55	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.16886242
56	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.15750425
57	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.15037588
58	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.15037588
59	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.14195578
60	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.13927359
61	CBP_20019798_ChIP-Seq_JUKART_Human	1.13927359
62	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.12958288
63	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.12958288
64	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.12052637
65	AHR_22903824_ChIP-Seq_MCF-7_Human	1.11774995
66	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.10946987
67	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.10813403
68	* RUNX2_22187159_ChIP-Seq_PCA_Human	1.10590811
69	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.09874179
70	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.09198625
71	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.09050634
72	RXR_22108803_ChIP-Seq_LS180_Human	1.08921589
73	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.08539422
74	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.08308319
75	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.07218993
76	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.06549458
77	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.05568523
78	FUS_26573619_Chip-Seq_HEK293_Human	1.05510602
79	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	1.04727703
80	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.03706187
81	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.03702005
82	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.03358695
83	SOX2_19829295_ChIP-Seq_ESCs_Human	1.02702547
84	NANOG_19829295_ChIP-Seq_ESCs_Human	1.02702547
85	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.02223127
86	* EWS_26573619_Chip-Seq_HEK293_Human	1.01294055
87	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.00907701
88	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.99956680
89	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.99843007
90	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.99672153
91	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.98200172
92	WT1_25993318_ChIP-Seq_PODOCYTE_Human	0.98159806
93	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.97624113
94	KDM2B_26808549_Chip-Seq_REH_Human	0.97602223
95	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.97144276
96	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.96795266
97	ESR1_20079471_ChIP-ChIP_T-47D_Human	0.96446269
98	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.96343655
99	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.96312048
100	TP53_16413492_ChIP-PET_HCT116_Human	0.95346965

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0010368_abnormal_lymphatic_system	7.82278119
2	MP0001879_abnormal_lymphatic_vessel	5.86366658
3	MP0005167_abnormal_blood-brain_barrier	5.37352710
4	MP0005670_abnormal_white_adipose	3.31058965
5	MP0006054_spinal_hemorrhage	3.30023002
6	MP0002138_abnormal_hepatobiliary_system	2.96254597
7	MP0003724_increased_susceptibility_to	2.91534900
8	MP0004272_abnormal_basement_membrane	2.88691952
9	MP0004084_abnormal_cardiac_muscle	2.61194069
10	MP0006138_congestive_heart_failure	2.48224494
11	MP0004145_abnormal_muscle_electrophysio	2.37786947
12	MP0004215_abnormal_myocardial_fiber	2.37208442
13	MP0003828_pulmonary_edema	2.35725231
14	MP0003646_muscle_fatigue	2.33896709
15	MP0004484_altered_response_of	2.17447468
16	MP0003195_calcinosis	2.16953082
17	MP0000013_abnormal_adipose_tissue	2.16390201
18	MP0000465_gastrointestinal_hemorrhage	2.06100416
19	MP0004130_abnormal_muscle_cell	2.04283878
20	MP0000767_abnormal_smooth_muscle	2.00941062
21	MP0005595_abnormal_vascular_smooth	1.94155424
22	MP0004036_abnormal_muscle_relaxation	1.89494744
23	MP0003950_abnormal_plasma_membrane	1.83389195
24	MP0003279_aneurysm	1.81479554
25	MP0008775_abnormal_heart_ventricle	1.59023230
26	MP0002127_abnormal_cardiovascular_syste	1.54703115
27	MP0000751_myopathy	1.51107776
28	MP0005385_cardiovascular_system_phenoty	1.50157299
29	MP0001544_abnormal_cardiovascular_syste	1.50157299
30	MP0002933_joint_inflammation	1.48716609
31	MP0002332_abnormal_exercise_endurance	1.47597452
32	MP0004085_abnormal_heartbeat	1.46951828
33	MP0005165_increased_susceptibility_to	1.46573245
34	MP0005620_abnormal_muscle_contractility	1.44116027
35	MP0000003_abnormal_adipose_tissue	1.38262151
36	MP0000249_abnormal_blood_vessel	1.38178604
37	MP0002638_abnormal_pupillary_reflex	1.37743816
38	MP0003045_fibrosis	1.37451948
39	MP0002295_abnormal_pulmonary_circulatio	1.35991631
40	MP0002876_abnormal_thyroid_physiology	1.33694328
41	MP0002972_abnormal_cardiac_muscle	1.29478638
42	MP0005375_adipose_tissue_phenotype	1.26895546
43	MP0004885_abnormal_endolymph	1.22151655
44	MP0000749_muscle_degeneration	1.21144052
45	MP0006276_abnormal_autonomic_nervous	1.20913724
46	MP0003303_peritoneal_inflammation	1.20291091
47	MP0002837_dystrophic_cardiac_calcinosis	1.18512320
48	MP0002128_abnormal_blood_circulation	1.17773355
49	MP0000230_abnormal_systemic_arterial	1.17416148
50	MP0001501_abnormal_sleep_pattern	1.16905019
51	MP0004147_increased_porphyrin_level	1.16560447
52	MP0001614_abnormal_blood_vessel	1.12917270
53	MP0005551_abnormal_eye_electrophysiolog	1.12720945
54	MP0005084_abnormal_gallbladder_morpholo	1.12254762
55	MP0005330_cardiomyopathy	1.02603555
56	MP0002925_abnormal_cardiovascular_devel	0.99603040
57	MP0002108_abnormal_muscle_morphology	0.98854715
58	MP0002971_abnormal_brown_adipose	0.98602670
59	MP0005666_abnormal_adipose_tissue	0.95722036
60	MP0002106_abnormal_muscle_physiology	0.95091433
61	MP0002168_other_aberrant_phenotype	0.93478970
62	MP0003868_abnormal_feces_composition	0.88248293
63	MP0003137_abnormal_impulse_conducting	0.87861526
64	MP0005369_muscle_phenotype	0.87737068
65	MP0004782_abnormal_surfactant_physiolog	0.87503591
66	MP0010329_abnormal_lipoprotein_level	0.86911895
67	MP0004043_abnormal_pH_regulation	0.85572532
68	MP0005187_abnormal_penis_morphology	0.78077850
69	MP0003633_abnormal_nervous_system	0.77044193
70	MP0004087_abnormal_muscle_fiber	0.75307317
71	MP0009780_abnormal_chondrocyte_physiolo	0.72471285
72	MP0001486_abnormal_startle_reflex	0.72137763
73	MP0000266_abnormal_heart_morphology	0.72005401
74	MP0005253_abnormal_eye_physiology	0.71916852
75	MP0010630_abnormal_cardiac_muscle	0.70828876
76	MP0001784_abnormal_fluid_regulation	0.70327128
77	MP0003638_abnormal_response/metabolism_	0.67109498
78	MP0009115_abnormal_fat_cell	0.65145427
79	MP0005275_abnormal_skin_tensile	0.58544903
80	MP0003943_abnormal_hepatobiliary_system	0.57439785
81	MP0005535_abnormal_body_temperature	0.57141032
82	MP0005409_darkened_coat_color	0.56091128
83	MP0005266_abnormal_metabolism	0.53837117
84	MP0005503_abnormal_tendon_morphology	0.50785810
85	MP0000343_altered_response_to	0.50440849
86	MP0000759_abnormal_skeletal_muscle	0.49888748
87	MP0009046_muscle_twitch	0.49491170
88	MP0001915_intracranial_hemorrhage	0.49120039
89	MP0001968_abnormal_touch/_nociception	0.46631197
90	MP0003959_abnormal_lean_body	0.46500768
91	MP0003948_abnormal_gas_homeostasis	0.46274181
92	MP0005448_abnormal_energy_balance	0.45941287
93	MP0002118_abnormal_lipid_homeostasis	0.45354957
94	MP0005334_abnormal_fat_pad	0.44400356
95	MP0002970_abnormal_white_adipose	0.43215674
96	MP0003631_nervous_system_phenotype	0.42813915
97	MP0005195_abnormal_posterior_eye	0.41944915
98	MP0001485_abnormal_pinna_reflex	0.41383713
99	MP0000372_irregular_coat_pigmentation	0.40030670
100	MP0009745_abnormal_behavioral_response	0.40026564

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hematochezia (HP:0002573)	5.18102411
2	Muscle fiber splitting (HP:0003555)	4.10713960
3	Spontaneous hematomas (HP:0007420)	3.74892230
4	Cerebral hemorrhage (HP:0001342)	3.69833537
5	Lymphangioma (HP:0100764)	3.67249098
6	Adactyly (HP:0009776)	3.54352764
7	Portal hypertension (HP:0001409)	3.51131590
8	Nonimmune hydrops fetalis (HP:0001790)	3.32371669
9	Wrist flexion contracture (HP:0001239)	3.29763585
10	Esophageal varix (HP:0002040)	3.28612895
11	Difficulty running (HP:0009046)	3.17346514
12	Polycythemia (HP:0001901)	3.15087679
13	Hyporeflexia of lower limbs (HP:0002600)	3.14181863
14	Abnormality of the hepatic vasculature (HP:0006707)	3.10822469
15	Attenuation of retinal blood vessels (HP:0007843)	3.00778064
16	Atrial fibrillation (HP:0005110)	3.00190184
17	Heart block (HP:0012722)	2.94722287
18	Skull defect (HP:0001362)	2.92067314
19	Congenital stationary night blindness (HP:0007642)	2.91591056
20	Hyperventilation (HP:0002883)	2.90977987
21	Scotoma (HP:0000575)	2.87486114
22	Supraventricular arrhythmia (HP:0005115)	2.84257060
23	Myotonia (HP:0002486)	2.82103254
24	Pancreatic cysts (HP:0001737)	2.77874539
25	Primary atrial arrhythmia (HP:0001692)	2.77348454
26	Atrioventricular block (HP:0001678)	2.77270602
27	Decreased circulating renin level (HP:0003351)	2.74131365
28	Bulbous nose (HP:0000414)	2.71696280
29	Abnormal atrioventricular conduction (HP:0005150)	2.62969469
30	Keratoconus (HP:0000563)	2.62944240
31	Increased corneal curvature (HP:0100692)	2.62944240
32	Pigmentary retinal degeneration (HP:0001146)	2.62617438
33	Supraventricular tachycardia (HP:0004755)	2.58480112
34	Bundle branch block (HP:0011710)	2.55625036
35	Cerebral aneurysm (HP:0004944)	2.52937599
36	Calf muscle hypertrophy (HP:0008981)	2.51897407
37	Abnormality of macular pigmentation (HP:0008002)	2.50027645
38	Areflexia of lower limbs (HP:0002522)	2.48515372
39	Muscle hypertrophy of the lower extremities (HP:0008968)	2.46865189
40	Conjunctival telangiectasia (HP:0000524)	2.46155141
41	Muscle fiber inclusion bodies (HP:0100299)	2.45864319
42	Myocardial infarction (HP:0001658)	2.45255902
43	Hyperlipoproteinemia (HP:0010980)	2.43947968
44	Visceral angiomatosis (HP:0100761)	2.41574165
45	Facial diplegia (HP:0001349)	2.40876028
46	Nemaline bodies (HP:0003798)	2.39623231
47	Prolonged QT interval (HP:0001657)	2.38313076
48	Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)	2.36113315
49	Oligomenorrhea (HP:0000876)	2.35247474
50	Hemiplegia (HP:0002301)	2.33227725
51	Absent hand (HP:0004050)	2.27088344
52	Abnormality of the renal cortex (HP:0011035)	2.24822303
53	True hermaphroditism (HP:0010459)	2.24691962
54	Syncope (HP:0001279)	2.21277980
55	Central scotoma (HP:0000603)	2.21226267
56	Congenital sensorineural hearing impairment (HP:0008527)	2.19721293
57	Pancreatic fibrosis (HP:0100732)	2.18826386
58	Decreased central vision (HP:0007663)	2.16630970
59	Distal arthrogryposis (HP:0005684)	2.16422539
60	Hemiparesis (HP:0001269)	2.14924236
61	Hemangiomatosis (HP:0007461)	2.14235164
62	Congenital hepatic fibrosis (HP:0002612)	2.13396207
63	Aortic aneurysm (HP:0004942)	2.13166498
64	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.13117266
65	Abnormality of the calf musculature (HP:0001430)	2.11926189
66	Polydipsia (HP:0001959)	2.10441668
67	Abnormal drinking behavior (HP:0030082)	2.10441668
68	Inability to walk (HP:0002540)	2.08601772
69	Aortic valve stenosis (HP:0001650)	2.08509666
70	Abnormality of midbrain morphology (HP:0002418)	2.06420333
71	Molar tooth sign on MRI (HP:0002419)	2.06420333
72	Hip contracture (HP:0003273)	2.05065213
73	Sudden death (HP:0001699)	2.03854118
74	Hyperkalemia (HP:0002153)	2.03549347
75	Broad-based gait (HP:0002136)	2.03536708
76	Congenital, generalized hypertrichosis (HP:0004540)	2.02849781
77	Abnormality of the renal medulla (HP:0100957)	2.02186435
78	Exotropia (HP:0000577)	2.01540454
79	Occipital encephalocele (HP:0002085)	2.01106348
80	Increased variability in muscle fiber diameter (HP:0003557)	2.00935641
81	Bony spicule pigmentary retinopathy (HP:0007737)	1.97227031
82	Delayed CNS myelination (HP:0002188)	1.96473033
83	Type 1 muscle fiber predominance (HP:0003803)	1.94500514
84	Nephronophthisis (HP:0000090)	1.94372938
85	Tubular atrophy (HP:0000092)	1.94109579
86	Cystic liver disease (HP:0006706)	1.91695556
87	Abnormality of skeletal muscle fiber size (HP:0012084)	1.91509058
88	EMG: myopathic abnormalities (HP:0003458)	1.90996775
89	Asymmetric septal hypertrophy (HP:0001670)	1.89680960
90	Prominent supraorbital ridges (HP:0000336)	1.88782589
91	Abnormality of the ischium (HP:0003174)	1.88466418
92	Type II lissencephaly (HP:0007260)	1.87179068
93	Abolished electroretinogram (ERG) (HP:0000550)	1.84520138
94	Febrile seizures (HP:0002373)	1.82833719
95	Porencephaly (HP:0002132)	1.82513943
96	Lipoatrophy (HP:0100578)	1.81608878
97	Chronic hepatic failure (HP:0100626)	1.81249400
98	Abnormal EKG (HP:0003115)	1.79581924
99	Large for gestational age (HP:0001520)	1.78458726
100	Arterial tortuosity (HP:0005116)	1.78171352

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	KDR	4.33991341
2	FRK	4.17069068
3	TGFBR2	2.61577668
4	FER	2.52638773
5	BMPR1B	2.18731091
6	TIE1	11.5063444
7	GRK1	1.86709258
8	TGFBR1	1.85338044
9	EPHB2	1.82936044
10	FES	1.75150942
11	OBSCN	1.67613246
12	TEC	1.52866080
13	PTK2B	1.51540152
14	INSRR	1.34618153
15	PINK1	1.27935153
16	ACVR1B	1.26486916
17	MAPKAPK3	1.23141164
18	MYLK	1.18293908
19	ADRBK2	1.15463695
20	WNK3	1.15083259
21	MAPK13	1.12141753
22	PRKAA2	1.10478945
23	PHKG2	0.96806023
24	PHKG1	0.96806023
25	EPHA3	0.95810385
26	STK38L	0.94238842
27	TRPM7	0.91775237
28	NLK	0.90732000
29	DAPK2	0.89994426
30	MAP4K2	0.87218250
31	NUAK1	0.84512957
32	GRK5	0.78099267
33	NTRK3	0.76360446
34	ADRBK1	0.74817027
35	STK39	0.72530333
36	PIK3CG	0.71807617
37	MAP3K7	0.71117302
38	PAK3	0.69936559
39	LATS1	0.68326081
40	MAPK12	0.62044688
41	PRKG2	0.61445255
42	PRKCE	0.60785317
43	RIPK1	0.60271194
44	MAPKAPK5	0.58636165
45	OXSR1	0.57432330
46	TAOK3	0.57195104
47	IRAK1	0.56730156
48	PKN1	0.56674382
49	KIT	0.56102826
50	CAMK1	0.54831664
51	FLT3	0.54258605
52	ROCK1	0.53632565
53	PIK3CA	0.52970506
54	PRKD1	0.51559520
55	IGF1R	0.46451744
56	CSK	0.45342469
57	TTN	0.42662943
58	TXK	0.41695470
59	PRKAA1	0.41293448
60	MARK1	0.41165467
61	CAMK2A	0.40730250
62	STK38	0.40061210
63	MAPK15	0.39076722
64	FGFR2	0.38855064
65	EPHB1	0.37797304
66	PRKD3	0.37723476
67	ITK	0.37423735
68	SGK2	0.35983510
69	MAPK7	0.34898116
70	PRKG1	0.33734802
71	PDK2	0.32366001
72	MET	0.30222365
73	PTK2	0.30203102
74	MAP2K1	0.29900493
75	CASK	0.29774107
76	TNIK	0.28604659
77	CSNK1G1	0.27618412
78	AKT3	0.25506247
79	MAPK4	0.25256782
80	EEF2K	0.25000362
81	ZAP70	0.23641761
82	PLK2	0.22912156
83	MKNK2	0.22560640
84	PRKACA	0.22410058
85	TNK2	0.22275024
86	HCK	0.21935993
87	CDC42BPA	0.21284150
88	CAMK4	0.21146649
89	STK11	0.20968004
90	EGFR	0.20543098
91	NTRK1	0.20465022
92	BCR	0.20430002
93	PDGFRB	0.20255225
94	GSK3A	0.19694405
95	MAP2K6	0.19002488
96	MUSK	0.18141510
97	ABL1	0.16511265
98	CAMKK2	0.16487763
99	ZAK	0.16043182
100	ROCK2	0.15772757

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	2.28596901
2	Tryptophan metabolism_Homo sapiens_hsa00380	2.11831694
3	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.11134703
4	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.98686242
5	Linoleic acid metabolism_Homo sapiens_hsa00591	1.95343439
6	ABC transporters_Homo sapiens_hsa02010	1.94415701
7	Butanoate metabolism_Homo sapiens_hsa00650	1.93452626
8	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.92845103
9	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.89201892
10	Phototransduction_Homo sapiens_hsa04744	1.85916704
11	Nitrogen metabolism_Homo sapiens_hsa00910	1.80246530
12	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.76510118
13	ECM-receptor interaction_Homo sapiens_hsa04512	1.76272056
14	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.74477628
15	Glycerolipid metabolism_Homo sapiens_hsa00561	1.67481699
16	PPAR signaling pathway_Homo sapiens_hsa03320	1.61712580
17	Dilated cardiomyopathy_Homo sapiens_hsa05414	1.61068490
18	Morphine addiction_Homo sapiens_hsa05032	1.56031619
19	Histidine metabolism_Homo sapiens_hsa00340	1.55916986
20	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.51621340
21	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	1.50109793
22	Renin secretion_Homo sapiens_hsa04924	1.48201526
23	Fatty acid degradation_Homo sapiens_hsa00071	1.47236572
24	Ether lipid metabolism_Homo sapiens_hsa00565	1.45342729
25	Propanoate metabolism_Homo sapiens_hsa00640	1.40732163
26	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.40406687
27	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.34152236
28	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.26897918
29	Circadian entrainment_Homo sapiens_hsa04713	1.26605770
30	Focal adhesion_Homo sapiens_hsa04510	1.25398183
31	Calcium signaling pathway_Homo sapiens_hsa04020	1.24482605
32	Complement and coagulation cascades_Homo sapiens_hsa04610	1.24252800
33	beta-Alanine metabolism_Homo sapiens_hsa00410	1.24124579
34	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.23132432
35	Serotonergic synapse_Homo sapiens_hsa04726	1.21649578
36	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.21505693
37	Salivary secretion_Homo sapiens_hsa04970	1.16988298
38	Ras signaling pathway_Homo sapiens_hsa04014	1.11735356
39	Glutamatergic synapse_Homo sapiens_hsa04724	1.10874261
40	Taste transduction_Homo sapiens_hsa04742	1.06326446
41	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.06098755
42	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.05239226
43	Rap1 signaling pathway_Homo sapiens_hsa04015	1.05237494
44	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.04495405
45	cAMP signaling pathway_Homo sapiens_hsa04024	1.03312475
46	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.03134145
47	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.03045926
48	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.99448843
49	Platelet activation_Homo sapiens_hsa04611	0.97752559
50	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.97502016
51	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.96253626
52	GABAergic synapse_Homo sapiens_hsa04727	0.96207440
53	Insulin secretion_Homo sapiens_hsa04911	0.96020568
54	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.95778571
55	Nicotine addiction_Homo sapiens_hsa05033	0.94380483
56	Circadian rhythm_Homo sapiens_hsa04710	0.93485328
57	Olfactory transduction_Homo sapiens_hsa04740	0.93201693
58	Fatty acid metabolism_Homo sapiens_hsa01212	0.91915234
59	Gastric acid secretion_Homo sapiens_hsa04971	0.91791989
60	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.89258800
61	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.88705966
62	Fat digestion and absorption_Homo sapiens_hsa04975	0.87942071
63	Tight junction_Homo sapiens_hsa04530	0.87852341
64	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.87204038
65	Regulation of autophagy_Homo sapiens_hsa04140	0.86719016
66	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.79578476
67	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.78952178
68	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.78854678
69	Axon guidance_Homo sapiens_hsa04360	0.78437531
70	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.78258778
71	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.74968272
72	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.72462360
73	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.71136671
74	Selenocompound metabolism_Homo sapiens_hsa00450	0.70657090
75	Retinol metabolism_Homo sapiens_hsa00830	0.70017667
76	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.69698001
77	Bile secretion_Homo sapiens_hsa04976	0.68115714
78	Protein digestion and absorption_Homo sapiens_hsa04974	0.67608883
79	Chemical carcinogenesis_Homo sapiens_hsa05204	0.65177075
80	Peroxisome_Homo sapiens_hsa04146	0.64839686
81	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.64094018
82	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.62778810
83	Adherens junction_Homo sapiens_hsa04520	0.60704991
84	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.60471829
85	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.60351802
86	Arginine and proline metabolism_Homo sapiens_hsa00330	0.60049027
87	Pancreatic secretion_Homo sapiens_hsa04972	0.59877279
88	Lysine degradation_Homo sapiens_hsa00310	0.56398148
89	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.53975189
90	Cholinergic synapse_Homo sapiens_hsa04725	0.52489609
91	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.50472940
92	Long-term depression_Homo sapiens_hsa04730	0.48993252
93	Arginine biosynthesis_Homo sapiens_hsa00220	0.47049387
94	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.45967857
95	Tyrosine metabolism_Homo sapiens_hsa00350	0.44873713
96	Sulfur metabolism_Homo sapiens_hsa00920	0.44256871
97	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.44033984
98	Renin-angiotensin system_Homo sapiens_hsa04614	0.43726932
99	Cardiac muscle contraction_Homo sapiens_hsa04260	0.43386179
100	Insulin resistance_Homo sapiens_hsa04931	0.41218805

CXORF36

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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