CXORF40A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.99210080
2positive regulation of protein homooligomerization (GO:0032464)3.90378338
3iron-sulfur cluster assembly (GO:0016226)3.50132175
4metallo-sulfur cluster assembly (GO:0031163)3.50132175
5deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.47595513
6viral protein processing (GO:0019082)3.32935233
7protein maturation by protein folding (GO:0022417)3.26786897
8positive regulation of release of cytochrome c from mitochondria (GO:0090200)3.25620402
9mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.24271570
10protein complex biogenesis (GO:0070271)3.19166852
11regulation of oxidative phosphorylation (GO:0002082)3.14272189
12pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.11764030
13proteasome assembly (GO:0043248)3.05454166
14peroxisome fission (GO:0016559)3.02342673
15activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.98477489
16pyrimidine nucleotide catabolic process (GO:0006244)2.97347855
17respiratory electron transport chain (GO:0022904)2.93718863
18cytidine catabolic process (GO:0006216)2.92524415
19cytidine deamination (GO:0009972)2.92524415
20cytidine metabolic process (GO:0046087)2.92524415
21ATP hydrolysis coupled proton transport (GO:0015991)2.91836710
22energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.91836710
23electron transport chain (GO:0022900)2.89071236
24virion assembly (GO:0019068)2.85946725
25protein targeting to mitochondrion (GO:0006626)2.84441128
26organelle membrane fusion (GO:0090174)2.84002596
27pyrimidine ribonucleoside catabolic process (GO:0046133)2.81473819
28GDP-mannose metabolic process (GO:0019673)2.81097572
29regulation of interleukin-2 biosynthetic process (GO:0045076)2.80143211
30regulation of release of cytochrome c from mitochondria (GO:0090199)2.79459972
31mitochondrial respiratory chain complex assembly (GO:0033108)2.78219036
32protein neddylation (GO:0045116)2.77675088
33positive regulation of mitochondrial fission (GO:0090141)2.75436992
34positive regulation of protein oligomerization (GO:0032461)2.71968858
35base-excision repair, AP site formation (GO:0006285)2.70789127
36establishment of protein localization to mitochondrion (GO:0072655)2.70726979
37mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.69645457
38mitochondrial respiratory chain complex I assembly (GO:0032981)2.69645457
39NADH dehydrogenase complex assembly (GO:0010257)2.69645457
40positive regulation of gamma-delta T cell activation (GO:0046645)2.63796586
41cellular response to interleukin-15 (GO:0071350)2.63399206
42NIK/NF-kappaB signaling (GO:0038061)2.63056529
43DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.61768487
44DNA deamination (GO:0045006)2.61202148
45protein localization to mitochondrion (GO:0070585)2.59512917
46antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.56993314
47mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.55481740
48purine nucleotide salvage (GO:0032261)2.53168329
49autophagic vacuole fusion (GO:0000046)2.53160517
50piRNA metabolic process (GO:0034587)2.51781938
51L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.51584041
52pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.51206086
53regulation of mitochondrial translation (GO:0070129)2.50581807
54entrainment of circadian clock by photoperiod (GO:0043153)2.49376516
55regulation of cellular respiration (GO:0043457)2.48926080
56heart contraction (GO:0060047)2.48650505
57heart process (GO:0003015)2.48650505
58negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.48120110
59negative regulation of cell killing (GO:0031342)2.48120110
60regulation of cellular amino acid metabolic process (GO:0006521)2.48030783
61antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.47936557
62regulation of protein homooligomerization (GO:0032462)2.47509467
63positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.47418677
64leukocyte degranulation (GO:0043299)2.46510510
65intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.46478259
66signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.46478259
67negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.45256934
68negative regulation of myeloid cell apoptotic process (GO:0033033)2.44332650
69RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.43928519
70tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.43928519
71nucleotide salvage (GO:0043173)2.43469493
72positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.43405569
73energy coupled proton transport, down electrochemical gradient (GO:0015985)2.40100545
74ATP synthesis coupled proton transport (GO:0015986)2.40100545
75immunoglobulin mediated immune response (GO:0016064)2.39823842
76chaperone-mediated protein transport (GO:0072321)2.39297690
77signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.39084188
78signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.39084188
79signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.39084188
80ribosomal small subunit biogenesis (GO:0042274)2.38779673
81signal transduction involved in cell cycle checkpoint (GO:0072395)2.35808954
82neutrophil activation involved in immune response (GO:0002283)2.35716539
83phagosome maturation (GO:0090382)2.35575835
84male meiosis I (GO:0007141)2.34673414
85mast cell activation involved in immune response (GO:0002279)2.33686074
86mast cell degranulation (GO:0043303)2.33686074
87signal transduction involved in DNA integrity checkpoint (GO:0072401)2.33663712
88signal transduction involved in DNA damage checkpoint (GO:0072422)2.33663712
89positive regulation of ligase activity (GO:0051351)2.29944583
90transferrin transport (GO:0033572)2.28911510
91release of cytochrome c from mitochondria (GO:0001836)2.28411568
92negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.27153227
93negative regulation of ligase activity (GO:0051352)2.27153227
94meiosis I (GO:0007127)2.25952392
95regulation of B cell receptor signaling pathway (GO:0050855)2.25375742
96mitochondrial calcium ion homeostasis (GO:0051560)2.24705598
97response to peptidoglycan (GO:0032494)2.24679822
98antigen processing and presentation of endogenous antigen (GO:0019883)2.24307617
99T cell migration (GO:0072678)2.23217529
100positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.22306980

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.51963917
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.78824747
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.68630887
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.28847984
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.15918151
6HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.03187727
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.99035461
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.88324995
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.66391626
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.45122732
11PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.44612348
12MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.41170262
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.36511075
14THAP11_20581084_ChIP-Seq_MESCs_Mouse2.33702828
15EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.28916493
16GABP_19822575_ChIP-Seq_HepG2_Human2.16466005
17FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.08113135
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.05761132
19VDR_23849224_ChIP-Seq_CD4+_Human2.05537546
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.04903814
21CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.02816582
22SRF_21415370_ChIP-Seq_HL-1_Mouse1.99507330
23SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.93815779
24VDR_21846776_ChIP-Seq_THP-1_Human1.86098395
25DCP1A_22483619_ChIP-Seq_HELA_Human1.84824226
26TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82950868
27FOXP3_21729870_ChIP-Seq_TREG_Human1.78318439
28MYC_18358816_ChIP-ChIP_MESCs_Mouse1.78259248
29TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.72327448
30MAF_26560356_Chip-Seq_TH2_Human1.70168648
31MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.69128017
32IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.67722265
33CIITA_25753668_ChIP-Seq_RAJI_Human1.67187669
34HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.67122336
35XRN2_22483619_ChIP-Seq_HELA_Human1.66452681
36TFEB_21752829_ChIP-Seq_HELA_Human1.66396687
37* SPI1_23547873_ChIP-Seq_NB4_Human1.65390534
38HOXB4_20404135_ChIP-ChIP_EML_Mouse1.64283109
39STAT4_19710469_ChIP-ChIP_TH1__Mouse1.63741544
40CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.57810991
41RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.55609146
42TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.53786673
43BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.51697435
44ELF1_20517297_ChIP-Seq_JURKAT_Human1.50048155
45SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.49880761
46UTX_26944678_Chip-Seq_JUKART_Human1.49526385
47KDM5A_27292631_Chip-Seq_BREAST_Human1.49460213
48DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.47324848
49SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.47101439
50MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.45714685
51BCL6_27268052_Chip-Seq_Bcells_Human1.43627789
52CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.43137169
53YY1_21170310_ChIP-Seq_MESCs_Mouse1.42137788
54IRF8_21731497_ChIP-ChIP_J774_Mouse1.41267652
55MYC_22102868_ChIP-Seq_BL_Human1.41154406
56TET1_21451524_ChIP-Seq_MESCs_Mouse1.38563643
57CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.36294052
58THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.35476872
59ERG_20887958_ChIP-Seq_HPC-7_Mouse1.33877512
60FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.32848297
61CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.32807910
62CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.31424348
63ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.30368673
64PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30118136
65MAF_26560356_Chip-Seq_TH1_Human1.29704819
66MYB_26560356_Chip-Seq_TH2_Human1.28092548
67BCOR_27268052_Chip-Seq_Bcells_Human1.26759419
68MYC_18555785_ChIP-Seq_MESCs_Mouse1.25281578
69E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.23335159
70PU.1_20513432_ChIP-Seq_Bcells_Mouse1.22174926
71MYC_19030024_ChIP-ChIP_MESCs_Mouse1.21040290
72E2F1_18555785_ChIP-Seq_MESCs_Mouse1.20504083
73CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.20137674
74PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.15325043
75NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.15184691
76LXR_22292898_ChIP-Seq_THP-1_Human1.15085465
77PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14182000
78NELFA_20434984_ChIP-Seq_ESCs_Mouse1.13775277
79SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.12878041
80VDR_24763502_ChIP-Seq_THP-1_Human1.12787039
81ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.11615086
82CTCF_26484167_Chip-Seq_Bcells_Mouse1.10615476
83RUNX1_22412390_ChIP-Seq_EML_Mouse1.09736496
84P68_20966046_ChIP-Seq_HELA_Human1.09641888
85TTF2_22483619_ChIP-Seq_HELA_Human1.09323389
86GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.07428386
87SRY_22984422_ChIP-ChIP_TESTIS_Rat1.06769490
88STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.06407127
89* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06187462
90CTCF_18555785_ChIP-Seq_MESCs_Mouse1.05869894
91NOTCH1_21737748_ChIP-Seq_TLL_Human1.04593539
92SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03649856
93ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.03474248
94P300_27268052_Chip-Seq_Bcells_Human1.03347786
95MYB_26560356_Chip-Seq_TH1_Human1.02648311
96E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02393173
97ZFX_18555785_ChIP-Seq_MESCs_Mouse1.01733510
98LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.01119679
99TBX5_21415370_ChIP-Seq_HL-1_Mouse1.00626564
100YY1_22570637_ChIP-Seq_MALME-3M_Human0.99427512

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to3.10501211
2MP0005058_abnormal_lysosome_morphology2.99044803
3MP0006036_abnormal_mitochondrial_physio2.80380929
4MP0003806_abnormal_nucleotide_metabolis2.79023081
5MP0005451_abnormal_body_composition2.64260964
6MP0001790_abnormal_immune_system2.51056476
7MP0005387_immune_system_phenotype2.51056476
8MP0001835_abnormal_antigen_presentation2.48922356
9MP0000749_muscle_degeneration2.46975797
10MP0001800_abnormal_humoral_immune2.32207182
11MP0003763_abnormal_thymus_physiology2.29517471
12MP0005000_abnormal_immune_tolerance2.27227405
13MP0009785_altered_susceptibility_to2.24717963
14MP0008260_abnormal_autophagy2.21223605
15MP0009333_abnormal_splenocyte_physiolog2.21190237
16MP0000685_abnormal_immune_system2.13140464
17MP0003436_decreased_susceptibility_to2.09306634
18MP0002723_abnormal_immune_serum2.06044364
19MP0002132_abnormal_respiratory_system2.03758973
20MP0005025_abnormal_response_to1.90959058
21MP0009840_abnormal_foam_cell1.87243300
22MP0003172_abnormal_lysosome_physiology1.85581597
23MP0002420_abnormal_adaptive_immunity1.85267339
24MP0002148_abnormal_hypersensitivity_rea1.84996866
25MP0001819_abnormal_immune_cell1.82091912
26MP0002163_abnormal_gland_morphology1.81065433
27MP0002452_abnormal_antigen_presenting1.80681391
28MP0003786_premature_aging1.75325233
29MP0003186_abnormal_redox_activity1.66322760
30MP0002277_abnormal_respiratory_mucosa1.63995667
31MP0008789_abnormal_olfactory_epithelium1.60412512
32MP0001845_abnormal_inflammatory_respons1.59038444
33MP0002398_abnormal_bone_marrow1.58273789
34MP0000372_irregular_coat_pigmentation1.56847901
35MP0000716_abnormal_immune_system1.53395447
36MP0008995_early_reproductive_senescence1.48584243
37MP0005499_abnormal_olfactory_system1.39417625
38MP0005394_taste/olfaction_phenotype1.39417625
39MP0001727_abnormal_embryo_implantation1.38971315
40MP0003866_abnormal_defecation1.38597832
41MP0002419_abnormal_innate_immunity1.38351147
42MP0000689_abnormal_spleen_morphology1.37750053
43MP0000703_abnormal_thymus_morphology1.34831127
44MP0003724_increased_susceptibility_to1.33985250
45MP0002429_abnormal_blood_cell1.33441401
46MP0000015_abnormal_ear_pigmentation1.33177392
47MP0006035_abnormal_mitochondrial_morpho1.32722775
48MP0002722_abnormal_immune_system1.32691108
49MP0000678_abnormal_parathyroid_gland1.31359332
50MP0004233_abnormal_muscle_weight1.30903300
51MP0010155_abnormal_intestine_physiology1.29473225
52MP0002139_abnormal_hepatobiliary_system1.23673640
53MP0000343_altered_response_to1.22128559
54MP0005464_abnormal_platelet_physiology1.19244520
55MP0008469_abnormal_protein_level1.17606277
56MP0008058_abnormal_DNA_repair1.15110422
57MP0002138_abnormal_hepatobiliary_system1.14378325
58MP0000490_abnormal_crypts_of1.12244725
59MP0004510_myositis1.09623727
60MP0001873_stomach_inflammation1.09475342
61MP0003693_abnormal_embryo_hatching1.09300242
62MP0008004_abnormal_stomach_pH1.08973959
63MP0001764_abnormal_homeostasis1.08497446
64MP0002210_abnormal_sex_determination1.07772661
65MP0000750_abnormal_muscle_regeneration1.07677610
66MP0002332_abnormal_exercise_endurance1.07499515
67MP0001929_abnormal_gametogenesis1.00969719
68MP0002405_respiratory_system_inflammati0.98675875
69MP0005319_abnormal_enzyme/_coenzyme0.98654785
70MP0001853_heart_inflammation0.98458316
71MP0001529_abnormal_vocalization0.97348125
72MP0003646_muscle_fatigue0.93523249
73MP0003191_abnormal_cellular_cholesterol0.93219447
74MP0005330_cardiomyopathy0.91858818
75MP0005075_abnormal_melanosome_morpholog0.89763705
76MP0000013_abnormal_adipose_tissue0.88173997
77MP0002837_dystrophic_cardiac_calcinosis0.86928929
78MP0000759_abnormal_skeletal_muscle0.85978093
79MP0002269_muscular_atrophy0.82577090
80MP0005310_abnormal_salivary_gland0.81678769
81MP0002693_abnormal_pancreas_physiology0.81618147
82MP0005410_abnormal_fertilization0.81066368
83MP0001905_abnormal_dopamine_level0.80817105
84MP0003303_peritoneal_inflammation0.79360951
85MP0004381_abnormal_hair_follicle0.78937130
86MP0006082_CNS_inflammation0.78564936
87MP0001145_abnormal_male_reproductive0.74227501
88MP0003221_abnormal_cardiomyocyte_apopto0.73927197
89MP0000653_abnormal_sex_gland0.73012945
90MP0000751_myopathy0.71961730
91MP0000313_abnormal_cell_death0.70242738
92MP0005266_abnormal_metabolism0.70143325
93MP0003698_abnormal_male_reproductive0.69176723
94MP0000747_muscle_weakness0.67559365
95MP0002933_joint_inflammation0.67030063
96MP0005166_decreased_susceptibility_to0.65033615
97MP0005379_endocrine/exocrine_gland_phen0.64892760
98MP0009643_abnormal_urine_homeostasis0.64627960
99MP0000858_altered_metastatic_potential0.63827652
100MP0002160_abnormal_reproductive_system0.63272935

Predicted human phenotypes

RankGene SetZ-score
1Abnormal mitochondria in muscle tissue (HP:0008316)4.38430556
2Acute necrotizing encephalopathy (HP:0006965)4.26251170
3Mitochondrial inheritance (HP:0001427)3.69629023
4Progressive macrocephaly (HP:0004481)3.60830701
5Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.56441073
6Decreased activity of mitochondrial respiratory chain (HP:0008972)3.56441073
7Hepatocellular necrosis (HP:0001404)3.43352155
8Acute encephalopathy (HP:0006846)3.30579832
9Hepatic necrosis (HP:0002605)3.22359673
10Increased CSF lactate (HP:0002490)3.21315140
11Cholecystitis (HP:0001082)3.06613338
12Abnormal gallbladder physiology (HP:0012438)3.06613338
13Increased intramyocellular lipid droplets (HP:0012240)3.03101157
14Exercise intolerance (HP:0003546)2.92538309
15Increased IgM level (HP:0003496)2.80967038
16Increased muscle lipid content (HP:0009058)2.72205465
17Abnormality of macrophages (HP:0004311)2.68133314
18Exercise-induced myalgia (HP:0003738)2.62838354
19Cerebral edema (HP:0002181)2.62395650
20Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.59515143
21Ragged-red muscle fibers (HP:0003200)2.59058537
22Renal Fanconi syndrome (HP:0001994)2.58560552
23Muscle fiber atrophy (HP:0100295)2.57643002
24Abnormality of lateral ventricle (HP:0030047)2.56799451
25Type I transferrin isoform profile (HP:0003642)2.56684251
263-Methylglutaconic aciduria (HP:0003535)2.55055726
27Lactic acidosis (HP:0003128)2.54416296
28Chronic diarrhea (HP:0002028)2.49495341
29Recurrent abscess formation (HP:0002722)2.44942757
30Rhabdomyolysis (HP:0003201)2.40834618
31Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.38240368
32Type 2 muscle fiber atrophy (HP:0003554)2.37762701
33Stomatitis (HP:0010280)2.35332466
34Generalized aminoaciduria (HP:0002909)2.33786713
35Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.31933348
36Abnormal protein N-linked glycosylation (HP:0012347)2.31933348
37Abnormal protein glycosylation (HP:0012346)2.31933348
38Abnormal glycosylation (HP:0012345)2.31933348
39Reduced antithrombin III activity (HP:0001976)2.30839805
40Recurrent bacterial skin infections (HP:0005406)2.29557626
41Vacuolated lymphocytes (HP:0001922)2.26739689
42Recurrent cutaneous fungal infections (HP:0011370)2.24207236
43Chronic mucocutaneous candidiasis (HP:0002728)2.24207236
44Respiratory failure (HP:0002878)2.23054188
45Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.20314630
46Seborrheic dermatitis (HP:0001051)2.19383551
47Recurrent fungal infections (HP:0002841)2.15469062
48Increased serum lactate (HP:0002151)2.14842427
49Bulbar palsy (HP:0001283)2.10255284
50Myopathic facies (HP:0002058)2.09882755
51Hypokinesia (HP:0002375)2.09104482
52X-linked dominant inheritance (HP:0001423)2.09021938
53Hypertensive crisis (HP:0100735)2.08835112
54Progressive muscle weakness (HP:0003323)2.08511800
55Dyschromatopsia (HP:0007641)2.07210347
56Acute hepatic failure (HP:0006554)2.05405136
57Dicarboxylic aciduria (HP:0003215)2.04194756
58Abnormality of dicarboxylic acid metabolism (HP:0010995)2.04194756
59Gastrointestinal infarctions (HP:0005244)2.01933363
60Asymmetric septal hypertrophy (HP:0001670)2.01322653
61Myoglobinuria (HP:0002913)2.00472791
62Chronic obstructive pulmonary disease (HP:0006510)1.97950468
63Obstructive lung disease (HP:0006536)1.97950468
64Abnormality of glycolipid metabolism (HP:0010969)1.97453919
65Abnormality of liposaccharide metabolism (HP:0010968)1.97453919
66Abnormality of glycosphingolipid metabolism (HP:0004343)1.97453919
67Optic disc pallor (HP:0000543)1.96091485
68Abnormality of the anterior horn cell (HP:0006802)1.95335389
69Degeneration of anterior horn cells (HP:0002398)1.95335389
70Emotional lability (HP:0000712)1.95219465
71Microretrognathia (HP:0000308)1.92579863
72Fetal akinesia sequence (HP:0001989)1.91446032
73Joint swelling (HP:0001386)1.90549697
74Amniotic constriction ring (HP:0009775)1.90369794
75Abnormality of placental membranes (HP:0011409)1.90369794
76Respiratory difficulties (HP:0002880)1.90121331
77Cholelithiasis (HP:0001081)1.89699279
78Severe visual impairment (HP:0001141)1.89189874
79Easy fatigability (HP:0003388)1.88537379
80Secondary amenorrhea (HP:0000869)1.88415438
81Abnormality of T cells (HP:0002843)1.85737387
82Lethargy (HP:0001254)1.85464599
83Recurrent skin infections (HP:0001581)1.85207671
84Recurrent viral infections (HP:0004429)1.81083898
85Abnormality of fatty-acid metabolism (HP:0004359)1.80532626
86Ketosis (HP:0001946)1.77809374
87Poor suck (HP:0002033)1.75374270
88Rimmed vacuoles (HP:0003805)1.74528020
89Albinism (HP:0001022)1.73858242
90Meningitis (HP:0001287)1.73545145
91Absent rod-and cone-mediated responses on ERG (HP:0007688)1.73031462
92Abnormality of aromatic amino acid family metabolism (HP:0004338)1.72771009
93Exercise-induced muscle cramps (HP:0003710)1.72621830
94Premature ovarian failure (HP:0008209)1.72208186
95Abnormality of T cell physiology (HP:0011840)1.70952549
96Abnormal gallbladder morphology (HP:0012437)1.70573463
97Lymphopenia (HP:0001888)1.69050805
98Elevated erythrocyte sedimentation rate (HP:0003565)1.67918210
99Cortical visual impairment (HP:0100704)1.67780654
100Panhypogammaglobulinemia (HP:0003139)1.67294042

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME23.87215551
2VRK23.64405930
3STK162.98009210
4PDK22.58583236
5MAP4K12.53527228
6BCKDK2.40042631
7TESK12.36090714
8TESK22.31402867
9IRAK32.28970514
10RIPK42.26514569
11TXK2.00192313
12TBK11.95121292
13MARK31.89449787
14VRK11.87833289
15TYK21.81974243
16OBSCN1.81459841
17MUSK1.71118143
18ILK1.68171800
19PRPF4B1.63486717
20IRAK41.58731053
21IKBKE1.47924098
22ARAF1.46825859
23MAP2K71.46583868
24LIMK11.46091414
25IKBKB1.42109806
26TNK21.40794803
27KDR1.36340277
28EIF2AK31.35793279
29MAP3K131.35224018
30MAP3K121.35121505
31CSNK1G31.33363906
32TLK11.31520008
33TAOK31.30189455
34FES1.26340977
35EIF2AK11.25991851
36MST41.25570709
37PINK11.25445160
38PRKCQ1.19031182
39SIK31.17895323
40TRIM281.14529695
41MAP3K111.11287645
42NEK11.11136784
43LRRK21.10253396
44PRKCI0.99160307
45BMPR20.99001561
46CSNK1A1L0.98196861
47MAP3K140.94926900
48IRAK20.91086799
49CAMKK20.91016085
50SYK0.87970373
51MAPK120.87341803
52NME10.87211833
53CCNB10.86677930
54PHKG10.86213695
55PHKG20.86213695
56MAP2K30.86167675
57CDK90.84163941
58CSNK1G20.83677359
59GRK60.82349842
60PDK10.78311993
61MAP4K20.77833453
62ZAP700.73279474
63MAPK110.73002535
64BLK0.71523336
65PAK10.70965059
66RPS6KA50.66287369
67TAOK20.64176170
68CSNK1G10.64157937
69MATK0.62689110
70TRIB30.62619716
71PKN20.62375639
72DAPK10.62235379
73PDPK10.60871195
74MAP3K50.60459531
75BTK0.58450284
76MAPK150.57668182
77LYN0.57497863
78ERN10.57306429
79CSF1R0.57296598
80CDK190.56718867
81MAP2K60.55738074
82BUB10.53740183
83MAP3K10.49642838
84PIM20.49271613
85AURKA0.46927846
86CSK0.46785135
87CAMKK10.44733785
88JAK20.43075293
89STK100.41784681
90PRKD10.40341894
91SIK10.40058331
92ZAK0.39646306
93DAPK30.38345346
94SMG10.37853696
95MAP3K30.37706899
96KSR10.35682703
97ITK0.35366383
98MAPKAPK30.35206347
99CSNK2A10.34157470
100MAPKAPK20.32818856

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.80264522
2Parkinsons disease_Homo sapiens_hsa050123.37804857
3Proteasome_Homo sapiens_hsa030503.24854000
4Primary immunodeficiency_Homo sapiens_hsa053402.61832895
5Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.54527390
6Collecting duct acid secretion_Homo sapiens_hsa049662.44871197
7Sulfur relay system_Homo sapiens_hsa041222.12238446
8Ribosome_Homo sapiens_hsa030102.10570241
9Huntingtons disease_Homo sapiens_hsa050162.06318641
10Alzheimers disease_Homo sapiens_hsa050102.01234786
11Protein export_Homo sapiens_hsa030601.89282939
12SNARE interactions in vesicular transport_Homo sapiens_hsa041301.80968270
13Vibrio cholerae infection_Homo sapiens_hsa051101.78767802
14Other glycan degradation_Homo sapiens_hsa005111.76022563
15RNA polymerase_Homo sapiens_hsa030201.70630958
16Allograft rejection_Homo sapiens_hsa053301.58135791
17Autoimmune thyroid disease_Homo sapiens_hsa053201.56847446
18Sulfur metabolism_Homo sapiens_hsa009201.56184129
19Base excision repair_Homo sapiens_hsa034101.54094702
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.50497536
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.41287035
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.39314063
23Rheumatoid arthritis_Homo sapiens_hsa053231.37868250
24Graft-versus-host disease_Homo sapiens_hsa053321.36103588
25T cell receptor signaling pathway_Homo sapiens_hsa046601.34551179
26B cell receptor signaling pathway_Homo sapiens_hsa046621.30363596
27Butanoate metabolism_Homo sapiens_hsa006501.24050382
28Toll-like receptor signaling pathway_Homo sapiens_hsa046201.20662677
29Lysosome_Homo sapiens_hsa041421.20449495
30Measles_Homo sapiens_hsa051621.15369015
31Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.15329829
32Fructose and mannose metabolism_Homo sapiens_hsa000511.12318201
33Pentose phosphate pathway_Homo sapiens_hsa000301.09583649
34Type I diabetes mellitus_Homo sapiens_hsa049401.08957608
35Viral myocarditis_Homo sapiens_hsa054161.08800277
36Pyrimidine metabolism_Homo sapiens_hsa002401.08547168
37Regulation of autophagy_Homo sapiens_hsa041401.08497450
38Folate biosynthesis_Homo sapiens_hsa007901.06555285
39RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.06387443
40Intestinal immune network for IgA production_Homo sapiens_hsa046721.05367023
41Osteoclast differentiation_Homo sapiens_hsa043801.02227257
42Peroxisome_Homo sapiens_hsa041461.01764030
43Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.01602680
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.01180845
45Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.00321717
46Herpes simplex infection_Homo sapiens_hsa051681.00095579
47Epstein-Barr virus infection_Homo sapiens_hsa051691.00011052
48Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.95357527
49NF-kappa B signaling pathway_Homo sapiens_hsa040640.95030614
50Cardiac muscle contraction_Homo sapiens_hsa042600.94190794
51Fatty acid elongation_Homo sapiens_hsa000620.92720898
52Antigen processing and presentation_Homo sapiens_hsa046120.89755660
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.88032540
54Apoptosis_Homo sapiens_hsa042100.85342326
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.85332105
56Glutathione metabolism_Homo sapiens_hsa004800.84879141
57Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.84189612
58Synaptic vesicle cycle_Homo sapiens_hsa047210.84117445
59Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.82906832
60Basal transcription factors_Homo sapiens_hsa030220.80580075
61Carbon metabolism_Homo sapiens_hsa012000.79859246
62Tuberculosis_Homo sapiens_hsa051520.79690838
63Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.79018314
642-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.78962267
65N-Glycan biosynthesis_Homo sapiens_hsa005100.78094602
66RNA degradation_Homo sapiens_hsa030180.76168335
67Phagosome_Homo sapiens_hsa041450.76107720
68Glycosaminoglycan degradation_Homo sapiens_hsa005310.76096557
69Galactose metabolism_Homo sapiens_hsa000520.73187057
70Purine metabolism_Homo sapiens_hsa002300.70884703
71Acute myeloid leukemia_Homo sapiens_hsa052210.65895838
72Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.64416043
73Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.62475875
74Influenza A_Homo sapiens_hsa051640.61664033
75Legionellosis_Homo sapiens_hsa051340.61017801
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.60262270
77Spliceosome_Homo sapiens_hsa030400.59856548
78Hepatitis B_Homo sapiens_hsa051610.59694516
79Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.58954317
80Cyanoamino acid metabolism_Homo sapiens_hsa004600.57797535
81Asthma_Homo sapiens_hsa053100.57329640
82Metabolic pathways_Homo sapiens_hsa011000.57143341
83Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.56829145
84Shigellosis_Homo sapiens_hsa051310.56190935
85Hematopoietic cell lineage_Homo sapiens_hsa046400.55979116
86Circadian rhythm_Homo sapiens_hsa047100.54588729
87Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.53950778
88Nucleotide excision repair_Homo sapiens_hsa034200.52975563
89RNA transport_Homo sapiens_hsa030130.51846623
90Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51340489
91Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.49726260
92Endocytosis_Homo sapiens_hsa041440.49170468
93Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.46848474
94NOD-like receptor signaling pathway_Homo sapiens_hsa046210.46353773
95Salmonella infection_Homo sapiens_hsa051320.45053220
96Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44109718
97Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.43846918
98Chemokine signaling pathway_Homo sapiens_hsa040620.41378410
99Leishmaniasis_Homo sapiens_hsa051400.41368265
100Biosynthesis of amino acids_Homo sapiens_hsa012300.38171283

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