ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)	3.99210080
2	positive regulation of protein homooligomerization (GO:0032464)	3.90378338
3	iron-sulfur cluster assembly (GO:0016226)	3.50132175
4	metallo-sulfur cluster assembly (GO:0031163)	3.50132175
5	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.47595513
6	viral protein processing (GO:0019082)	3.32935233
7	protein maturation by protein folding (GO:0022417)	3.26786897
8	positive regulation of release of cytochrome c from mitochondria (GO:0090200)	3.25620402
9	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.24271570
10	protein complex biogenesis (GO:0070271)	3.19166852
11	regulation of oxidative phosphorylation (GO:0002082)	3.14272189
12	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.11764030
13	proteasome assembly (GO:0043248)	3.05454166
14	peroxisome fission (GO:0016559)	3.02342673
15	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO	2.98477489
16	pyrimidine nucleotide catabolic process (GO:0006244)	2.97347855
17	respiratory electron transport chain (GO:0022904)	2.93718863
18	cytidine catabolic process (GO:0006216)	2.92524415
19	cytidine deamination (GO:0009972)	2.92524415
20	cytidine metabolic process (GO:0046087)	2.92524415
21	ATP hydrolysis coupled proton transport (GO:0015991)	2.91836710
22	energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)	2.91836710
23	electron transport chain (GO:0022900)	2.89071236
24	virion assembly (GO:0019068)	2.85946725
25	protein targeting to mitochondrion (GO:0006626)	2.84441128
26	organelle membrane fusion (GO:0090174)	2.84002596
27	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.81473819
28	GDP-mannose metabolic process (GO:0019673)	2.81097572
29	regulation of interleukin-2 biosynthetic process (GO:0045076)	2.80143211
30	regulation of release of cytochrome c from mitochondria (GO:0090199)	2.79459972
31	mitochondrial respiratory chain complex assembly (GO:0033108)	2.78219036
32	protein neddylation (GO:0045116)	2.77675088
33	positive regulation of mitochondrial fission (GO:0090141)	2.75436992
34	positive regulation of protein oligomerization (GO:0032461)	2.71968858
35	base-excision repair, AP site formation (GO:0006285)	2.70789127
36	establishment of protein localization to mitochondrion (GO:0072655)	2.70726979
37	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.69645457
38	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.69645457
39	NADH dehydrogenase complex assembly (GO:0010257)	2.69645457
40	positive regulation of gamma-delta T cell activation (GO:0046645)	2.63796586
41	cellular response to interleukin-15 (GO:0071350)	2.63399206
42	NIK/NF-kappaB signaling (GO:0038061)	2.63056529
43	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.61768487
44	DNA deamination (GO:0045006)	2.61202148
45	protein localization to mitochondrion (GO:0070585)	2.59512917
46	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	2.56993314
47	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.55481740
48	purine nucleotide salvage (GO:0032261)	2.53168329
49	autophagic vacuole fusion (GO:0000046)	2.53160517
50	piRNA metabolic process (GO:0034587)	2.51781938
51	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.51584041
52	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.51206086
53	regulation of mitochondrial translation (GO:0070129)	2.50581807
54	entrainment of circadian clock by photoperiod (GO:0043153)	2.49376516
55	regulation of cellular respiration (GO:0043457)	2.48926080
56	heart contraction (GO:0060047)	2.48650505
57	heart process (GO:0003015)	2.48650505
58	negative regulation of leukocyte mediated cytotoxicity (GO:0001911)	2.48120110
59	negative regulation of cell killing (GO:0031342)	2.48120110
60	regulation of cellular amino acid metabolic process (GO:0006521)	2.48030783
61	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	2.47936557
62	regulation of protein homooligomerization (GO:0032462)	2.47509467
63	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.47418677
64	leukocyte degranulation (GO:0043299)	2.46510510
65	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.46478259
66	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.46478259
67	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.45256934
68	negative regulation of myeloid cell apoptotic process (GO:0033033)	2.44332650
69	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.43928519
70	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.43928519
71	nucleotide salvage (GO:0043173)	2.43469493
72	positive regulation of interleukin-2 biosynthetic process (GO:0045086)	2.43405569
73	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.40100545
74	ATP synthesis coupled proton transport (GO:0015986)	2.40100545
75	immunoglobulin mediated immune response (GO:0016064)	2.39823842
76	chaperone-mediated protein transport (GO:0072321)	2.39297690
77	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.39084188
78	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.39084188
79	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.39084188
80	ribosomal small subunit biogenesis (GO:0042274)	2.38779673
81	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.35808954
82	neutrophil activation involved in immune response (GO:0002283)	2.35716539
83	phagosome maturation (GO:0090382)	2.35575835
84	male meiosis I (GO:0007141)	2.34673414
85	mast cell activation involved in immune response (GO:0002279)	2.33686074
86	mast cell degranulation (GO:0043303)	2.33686074
87	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.33663712
88	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.33663712
89	positive regulation of ligase activity (GO:0051351)	2.29944583
90	transferrin transport (GO:0033572)	2.28911510
91	release of cytochrome c from mitochondria (GO:0001836)	2.28411568
92	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.27153227
93	negative regulation of ligase activity (GO:0051352)	2.27153227
94	meiosis I (GO:0007127)	2.25952392
95	regulation of B cell receptor signaling pathway (GO:0050855)	2.25375742
96	mitochondrial calcium ion homeostasis (GO:0051560)	2.24705598
97	response to peptidoglycan (GO:0032494)	2.24679822
98	antigen processing and presentation of endogenous antigen (GO:0019883)	2.24307617
99	T cell migration (GO:0072678)	2.23217529
100	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.22306980

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BP1_19119308_ChIP-ChIP_Hs578T_Human	4.51963917
2	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.78824747
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.68630887
4	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.28847984
5	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.15918151
6	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.03187727
7	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.99035461
8	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.88324995
9	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.66391626
10	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.45122732
11	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.44612348
12	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.41170262
13	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.36511075
14	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.33702828
15	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.28916493
16	GABP_19822575_ChIP-Seq_HepG2_Human	2.16466005
17	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	2.08113135
18	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.05761132
19	VDR_23849224_ChIP-Seq_CD4+_Human	2.05537546
20	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	2.04903814
21	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	2.02816582
22	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.99507330
23	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.93815779
24	VDR_21846776_ChIP-Seq_THP-1_Human	1.86098395
25	DCP1A_22483619_ChIP-Seq_HELA_Human	1.84824226
26	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.82950868
27	FOXP3_21729870_ChIP-Seq_TREG_Human	1.78318439
28	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.78259248
29	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.72327448
30	MAF_26560356_Chip-Seq_TH2_Human	1.70168648
31	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	1.69128017
32	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.67722265
33	CIITA_25753668_ChIP-Seq_RAJI_Human	1.67187669
34	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.67122336
35	XRN2_22483619_ChIP-Seq_HELA_Human	1.66452681
36	TFEB_21752829_ChIP-Seq_HELA_Human	1.66396687
37	* SPI1_23547873_ChIP-Seq_NB4_Human	1.65390534
38	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.64283109
39	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.63741544
40	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.57810991
41	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.55609146
42	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.53786673
43	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.51697435
44	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.50048155
45	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.49880761
46	UTX_26944678_Chip-Seq_JUKART_Human	1.49526385
47	KDM5A_27292631_Chip-Seq_BREAST_Human	1.49460213
48	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.47324848
49	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.47101439
50	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.45714685
51	BCL6_27268052_Chip-Seq_Bcells_Human	1.43627789
52	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.43137169
53	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.42137788
54	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.41267652
55	MYC_22102868_ChIP-Seq_BL_Human	1.41154406
56	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.38563643
57	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.36294052
58	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.35476872
59	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.33877512
60	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.32848297
61	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.32807910
62	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.31424348
63	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.30368673
64	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.30118136
65	MAF_26560356_Chip-Seq_TH1_Human	1.29704819
66	MYB_26560356_Chip-Seq_TH2_Human	1.28092548
67	BCOR_27268052_Chip-Seq_Bcells_Human	1.26759419
68	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.25281578
69	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.23335159
70	PU.1_20513432_ChIP-Seq_Bcells_Mouse	1.22174926
71	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.21040290
72	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.20504083
73	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.20137674
74	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.15325043
75	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	1.15184691
76	LXR_22292898_ChIP-Seq_THP-1_Human	1.15085465
77	PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse	1.14182000
78	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.13775277
79	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.12878041
80	VDR_24763502_ChIP-Seq_THP-1_Human	1.12787039
81	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.11615086
82	CTCF_26484167_Chip-Seq_Bcells_Mouse	1.10615476
83	RUNX1_22412390_ChIP-Seq_EML_Mouse	1.09736496
84	P68_20966046_ChIP-Seq_HELA_Human	1.09641888
85	TTF2_22483619_ChIP-Seq_HELA_Human	1.09323389
86	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	1.07428386
87	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.06769490
88	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.06407127
89	* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.06187462
90	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.05869894
91	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.04593539
92	SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	1.03649856
93	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.03474248
94	P300_27268052_Chip-Seq_Bcells_Human	1.03347786
95	MYB_26560356_Chip-Seq_TH1_Human	1.02648311
96	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.02393173
97	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.01733510
98	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.01119679
99	TBX5_21415370_ChIP-Seq_HL-1_Mouse	1.00626564
100	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.99427512

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	3.10501211
2	MP0005058_abnormal_lysosome_morphology	2.99044803
3	MP0006036_abnormal_mitochondrial_physio	2.80380929
4	MP0003806_abnormal_nucleotide_metabolis	2.79023081
5	MP0005451_abnormal_body_composition	2.64260964
6	MP0001790_abnormal_immune_system	2.51056476
7	MP0005387_immune_system_phenotype	2.51056476
8	MP0001835_abnormal_antigen_presentation	2.48922356
9	MP0000749_muscle_degeneration	2.46975797
10	MP0001800_abnormal_humoral_immune	2.32207182
11	MP0003763_abnormal_thymus_physiology	2.29517471
12	MP0005000_abnormal_immune_tolerance	2.27227405
13	MP0009785_altered_susceptibility_to	2.24717963
14	MP0008260_abnormal_autophagy	2.21223605
15	MP0009333_abnormal_splenocyte_physiolog	2.21190237
16	MP0000685_abnormal_immune_system	2.13140464
17	MP0003436_decreased_susceptibility_to	2.09306634
18	MP0002723_abnormal_immune_serum	2.06044364
19	MP0002132_abnormal_respiratory_system	2.03758973
20	MP0005025_abnormal_response_to	1.90959058
21	MP0009840_abnormal_foam_cell	1.87243300
22	MP0003172_abnormal_lysosome_physiology	1.85581597
23	MP0002420_abnormal_adaptive_immunity	1.85267339
24	MP0002148_abnormal_hypersensitivity_rea	1.84996866
25	MP0001819_abnormal_immune_cell	1.82091912
26	MP0002163_abnormal_gland_morphology	1.81065433
27	MP0002452_abnormal_antigen_presenting	1.80681391
28	MP0003786_premature_aging	1.75325233
29	MP0003186_abnormal_redox_activity	1.66322760
30	MP0002277_abnormal_respiratory_mucosa	1.63995667
31	MP0008789_abnormal_olfactory_epithelium	1.60412512
32	MP0001845_abnormal_inflammatory_respons	1.59038444
33	MP0002398_abnormal_bone_marrow	1.58273789
34	MP0000372_irregular_coat_pigmentation	1.56847901
35	MP0000716_abnormal_immune_system	1.53395447
36	MP0008995_early_reproductive_senescence	1.48584243
37	MP0005499_abnormal_olfactory_system	1.39417625
38	MP0005394_taste/olfaction_phenotype	1.39417625
39	MP0001727_abnormal_embryo_implantation	1.38971315
40	MP0003866_abnormal_defecation	1.38597832
41	MP0002419_abnormal_innate_immunity	1.38351147
42	MP0000689_abnormal_spleen_morphology	1.37750053
43	MP0000703_abnormal_thymus_morphology	1.34831127
44	MP0003724_increased_susceptibility_to	1.33985250
45	MP0002429_abnormal_blood_cell	1.33441401
46	MP0000015_abnormal_ear_pigmentation	1.33177392
47	MP0006035_abnormal_mitochondrial_morpho	1.32722775
48	MP0002722_abnormal_immune_system	1.32691108
49	MP0000678_abnormal_parathyroid_gland	1.31359332
50	MP0004233_abnormal_muscle_weight	1.30903300
51	MP0010155_abnormal_intestine_physiology	1.29473225
52	MP0002139_abnormal_hepatobiliary_system	1.23673640
53	MP0000343_altered_response_to	1.22128559
54	MP0005464_abnormal_platelet_physiology	1.19244520
55	MP0008469_abnormal_protein_level	1.17606277
56	MP0008058_abnormal_DNA_repair	1.15110422
57	MP0002138_abnormal_hepatobiliary_system	1.14378325
58	MP0000490_abnormal_crypts_of	1.12244725
59	MP0004510_myositis	1.09623727
60	MP0001873_stomach_inflammation	1.09475342
61	MP0003693_abnormal_embryo_hatching	1.09300242
62	MP0008004_abnormal_stomach_pH	1.08973959
63	MP0001764_abnormal_homeostasis	1.08497446
64	MP0002210_abnormal_sex_determination	1.07772661
65	MP0000750_abnormal_muscle_regeneration	1.07677610
66	MP0002332_abnormal_exercise_endurance	1.07499515
67	MP0001929_abnormal_gametogenesis	1.00969719
68	MP0002405_respiratory_system_inflammati	0.98675875
69	MP0005319_abnormal_enzyme/_coenzyme	0.98654785
70	MP0001853_heart_inflammation	0.98458316
71	MP0001529_abnormal_vocalization	0.97348125
72	MP0003646_muscle_fatigue	0.93523249
73	MP0003191_abnormal_cellular_cholesterol	0.93219447
74	MP0005330_cardiomyopathy	0.91858818
75	MP0005075_abnormal_melanosome_morpholog	0.89763705
76	MP0000013_abnormal_adipose_tissue	0.88173997
77	MP0002837_dystrophic_cardiac_calcinosis	0.86928929
78	MP0000759_abnormal_skeletal_muscle	0.85978093
79	MP0002269_muscular_atrophy	0.82577090
80	MP0005310_abnormal_salivary_gland	0.81678769
81	MP0002693_abnormal_pancreas_physiology	0.81618147
82	MP0005410_abnormal_fertilization	0.81066368
83	MP0001905_abnormal_dopamine_level	0.80817105
84	MP0003303_peritoneal_inflammation	0.79360951
85	MP0004381_abnormal_hair_follicle	0.78937130
86	MP0006082_CNS_inflammation	0.78564936
87	MP0001145_abnormal_male_reproductive	0.74227501
88	MP0003221_abnormal_cardiomyocyte_apopto	0.73927197
89	MP0000653_abnormal_sex_gland	0.73012945
90	MP0000751_myopathy	0.71961730
91	MP0000313_abnormal_cell_death	0.70242738
92	MP0005266_abnormal_metabolism	0.70143325
93	MP0003698_abnormal_male_reproductive	0.69176723
94	MP0000747_muscle_weakness	0.67559365
95	MP0002933_joint_inflammation	0.67030063
96	MP0005166_decreased_susceptibility_to	0.65033615
97	MP0005379_endocrine/exocrine_gland_phen	0.64892760
98	MP0009643_abnormal_urine_homeostasis	0.64627960
99	MP0000858_altered_metastatic_potential	0.63827652
100	MP0002160_abnormal_reproductive_system	0.63272935

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal mitochondria in muscle tissue (HP:0008316)	4.38430556
2	Acute necrotizing encephalopathy (HP:0006965)	4.26251170
3	Mitochondrial inheritance (HP:0001427)	3.69629023
4	Progressive macrocephaly (HP:0004481)	3.60830701
5	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.56441073
6	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.56441073
7	Hepatocellular necrosis (HP:0001404)	3.43352155
8	Acute encephalopathy (HP:0006846)	3.30579832
9	Hepatic necrosis (HP:0002605)	3.22359673
10	Increased CSF lactate (HP:0002490)	3.21315140
11	Cholecystitis (HP:0001082)	3.06613338
12	Abnormal gallbladder physiology (HP:0012438)	3.06613338
13	Increased intramyocellular lipid droplets (HP:0012240)	3.03101157
14	Exercise intolerance (HP:0003546)	2.92538309
15	Increased IgM level (HP:0003496)	2.80967038
16	Increased muscle lipid content (HP:0009058)	2.72205465
17	Abnormality of macrophages (HP:0004311)	2.68133314
18	Exercise-induced myalgia (HP:0003738)	2.62838354
19	Cerebral edema (HP:0002181)	2.62395650
20	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.59515143
21	Ragged-red muscle fibers (HP:0003200)	2.59058537
22	Renal Fanconi syndrome (HP:0001994)	2.58560552
23	Muscle fiber atrophy (HP:0100295)	2.57643002
24	Abnormality of lateral ventricle (HP:0030047)	2.56799451
25	Type I transferrin isoform profile (HP:0003642)	2.56684251
26	3-Methylglutaconic aciduria (HP:0003535)	2.55055726
27	Lactic acidosis (HP:0003128)	2.54416296
28	Chronic diarrhea (HP:0002028)	2.49495341
29	Recurrent abscess formation (HP:0002722)	2.44942757
30	Rhabdomyolysis (HP:0003201)	2.40834618
31	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.38240368
32	Type 2 muscle fiber atrophy (HP:0003554)	2.37762701
33	Stomatitis (HP:0010280)	2.35332466
34	Generalized aminoaciduria (HP:0002909)	2.33786713
35	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.31933348
36	Abnormal protein N-linked glycosylation (HP:0012347)	2.31933348
37	Abnormal protein glycosylation (HP:0012346)	2.31933348
38	Abnormal glycosylation (HP:0012345)	2.31933348
39	Reduced antithrombin III activity (HP:0001976)	2.30839805
40	Recurrent bacterial skin infections (HP:0005406)	2.29557626
41	Vacuolated lymphocytes (HP:0001922)	2.26739689
42	Recurrent cutaneous fungal infections (HP:0011370)	2.24207236
43	Chronic mucocutaneous candidiasis (HP:0002728)	2.24207236
44	Respiratory failure (HP:0002878)	2.23054188
45	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	2.20314630
46	Seborrheic dermatitis (HP:0001051)	2.19383551
47	Recurrent fungal infections (HP:0002841)	2.15469062
48	Increased serum lactate (HP:0002151)	2.14842427
49	Bulbar palsy (HP:0001283)	2.10255284
50	Myopathic facies (HP:0002058)	2.09882755
51	Hypokinesia (HP:0002375)	2.09104482
52	X-linked dominant inheritance (HP:0001423)	2.09021938
53	Hypertensive crisis (HP:0100735)	2.08835112
54	Progressive muscle weakness (HP:0003323)	2.08511800
55	Dyschromatopsia (HP:0007641)	2.07210347
56	Acute hepatic failure (HP:0006554)	2.05405136
57	Dicarboxylic aciduria (HP:0003215)	2.04194756
58	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.04194756
59	Gastrointestinal infarctions (HP:0005244)	2.01933363
60	Asymmetric septal hypertrophy (HP:0001670)	2.01322653
61	Myoglobinuria (HP:0002913)	2.00472791
62	Chronic obstructive pulmonary disease (HP:0006510)	1.97950468
63	Obstructive lung disease (HP:0006536)	1.97950468
64	Abnormality of glycolipid metabolism (HP:0010969)	1.97453919
65	Abnormality of liposaccharide metabolism (HP:0010968)	1.97453919
66	Abnormality of glycosphingolipid metabolism (HP:0004343)	1.97453919
67	Optic disc pallor (HP:0000543)	1.96091485
68	Abnormality of the anterior horn cell (HP:0006802)	1.95335389
69	Degeneration of anterior horn cells (HP:0002398)	1.95335389
70	Emotional lability (HP:0000712)	1.95219465
71	Microretrognathia (HP:0000308)	1.92579863
72	Fetal akinesia sequence (HP:0001989)	1.91446032
73	Joint swelling (HP:0001386)	1.90549697
74	Amniotic constriction ring (HP:0009775)	1.90369794
75	Abnormality of placental membranes (HP:0011409)	1.90369794
76	Respiratory difficulties (HP:0002880)	1.90121331
77	Cholelithiasis (HP:0001081)	1.89699279
78	Severe visual impairment (HP:0001141)	1.89189874
79	Easy fatigability (HP:0003388)	1.88537379
80	Secondary amenorrhea (HP:0000869)	1.88415438
81	Abnormality of T cells (HP:0002843)	1.85737387
82	Lethargy (HP:0001254)	1.85464599
83	Recurrent skin infections (HP:0001581)	1.85207671
84	Recurrent viral infections (HP:0004429)	1.81083898
85	Abnormality of fatty-acid metabolism (HP:0004359)	1.80532626
86	Ketosis (HP:0001946)	1.77809374
87	Poor suck (HP:0002033)	1.75374270
88	Rimmed vacuoles (HP:0003805)	1.74528020
89	Albinism (HP:0001022)	1.73858242
90	Meningitis (HP:0001287)	1.73545145
91	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.73031462
92	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.72771009
93	Exercise-induced muscle cramps (HP:0003710)	1.72621830
94	Premature ovarian failure (HP:0008209)	1.72208186
95	Abnormality of T cell physiology (HP:0011840)	1.70952549
96	Abnormal gallbladder morphology (HP:0012437)	1.70573463
97	Lymphopenia (HP:0001888)	1.69050805
98	Elevated erythrocyte sedimentation rate (HP:0003565)	1.67918210
99	Cortical visual impairment (HP:0100704)	1.67780654
100	Panhypogammaglobulinemia (HP:0003139)	1.67294042

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NME2	3.87215551
2	VRK2	3.64405930
3	STK16	2.98009210
4	PDK2	2.58583236
5	MAP4K1	2.53527228
6	BCKDK	2.40042631
7	TESK1	2.36090714
8	TESK2	2.31402867
9	IRAK3	2.28970514
10	RIPK4	2.26514569
11	TXK	2.00192313
12	TBK1	1.95121292
13	MARK3	1.89449787
14	VRK1	1.87833289
15	TYK2	1.81974243
16	OBSCN	1.81459841
17	MUSK	1.71118143
18	ILK	1.68171800
19	PRPF4B	1.63486717
20	IRAK4	1.58731053
21	IKBKE	1.47924098
22	ARAF	1.46825859
23	MAP2K7	1.46583868
24	LIMK1	1.46091414
25	IKBKB	1.42109806
26	TNK2	1.40794803
27	KDR	1.36340277
28	EIF2AK3	1.35793279
29	MAP3K13	1.35224018
30	MAP3K12	1.35121505
31	CSNK1G3	1.33363906
32	TLK1	1.31520008
33	TAOK3	1.30189455
34	FES	1.26340977
35	EIF2AK1	1.25991851
36	MST4	1.25570709
37	PINK1	1.25445160
38	PRKCQ	1.19031182
39	SIK3	1.17895323
40	TRIM28	1.14529695
41	MAP3K11	1.11287645
42	NEK1	1.11136784
43	LRRK2	1.10253396
44	PRKCI	0.99160307
45	BMPR2	0.99001561
46	CSNK1A1L	0.98196861
47	MAP3K14	0.94926900
48	IRAK2	0.91086799
49	CAMKK2	0.91016085
50	SYK	0.87970373
51	MAPK12	0.87341803
52	NME1	0.87211833
53	CCNB1	0.86677930
54	PHKG1	0.86213695
55	PHKG2	0.86213695
56	MAP2K3	0.86167675
57	CDK9	0.84163941
58	CSNK1G2	0.83677359
59	GRK6	0.82349842
60	PDK1	0.78311993
61	MAP4K2	0.77833453
62	ZAP70	0.73279474
63	MAPK11	0.73002535
64	BLK	0.71523336
65	PAK1	0.70965059
66	RPS6KA5	0.66287369
67	TAOK2	0.64176170
68	CSNK1G1	0.64157937
69	MATK	0.62689110
70	TRIB3	0.62619716
71	PKN2	0.62375639
72	DAPK1	0.62235379
73	PDPK1	0.60871195
74	MAP3K5	0.60459531
75	BTK	0.58450284
76	MAPK15	0.57668182
77	LYN	0.57497863
78	ERN1	0.57306429
79	CSF1R	0.57296598
80	CDK19	0.56718867
81	MAP2K6	0.55738074
82	BUB1	0.53740183
83	MAP3K1	0.49642838
84	PIM2	0.49271613
85	AURKA	0.46927846
86	CSK	0.46785135
87	CAMKK1	0.44733785
88	JAK2	0.43075293
89	STK10	0.41784681
90	PRKD1	0.40341894
91	SIK1	0.40058331
92	ZAK	0.39646306
93	DAPK3	0.38345346
94	SMG1	0.37853696
95	MAP3K3	0.37706899
96	KSR1	0.35682703
97	ITK	0.35366383
98	MAPKAPK3	0.35206347
99	CSNK2A1	0.34157470
100	MAPKAPK2	0.32818856

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.80264522
2	Parkinsons disease_Homo sapiens_hsa05012	3.37804857
3	Proteasome_Homo sapiens_hsa03050	3.24854000
4	Primary immunodeficiency_Homo sapiens_hsa05340	2.61832895
5	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.54527390
6	Collecting duct acid secretion_Homo sapiens_hsa04966	2.44871197
7	Sulfur relay system_Homo sapiens_hsa04122	2.12238446
8	Ribosome_Homo sapiens_hsa03010	2.10570241
9	Huntingtons disease_Homo sapiens_hsa05016	2.06318641
10	Alzheimers disease_Homo sapiens_hsa05010	2.01234786
11	Protein export_Homo sapiens_hsa03060	1.89282939
12	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.80968270
13	Vibrio cholerae infection_Homo sapiens_hsa05110	1.78767802
14	Other glycan degradation_Homo sapiens_hsa00511	1.76022563
15	RNA polymerase_Homo sapiens_hsa03020	1.70630958
16	Allograft rejection_Homo sapiens_hsa05330	1.58135791
17	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.56847446
18	Sulfur metabolism_Homo sapiens_hsa00920	1.56184129
19	Base excision repair_Homo sapiens_hsa03410	1.54094702
20	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.50497536
21	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.41287035
22	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.39314063
23	Rheumatoid arthritis_Homo sapiens_hsa05323	1.37868250
24	Graft-versus-host disease_Homo sapiens_hsa05332	1.36103588
25	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.34551179
26	B cell receptor signaling pathway_Homo sapiens_hsa04662	1.30363596
27	Butanoate metabolism_Homo sapiens_hsa00650	1.24050382
28	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	1.20662677
29	Lysosome_Homo sapiens_hsa04142	1.20449495
30	Measles_Homo sapiens_hsa05162	1.15369015
31	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.15329829
32	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.12318201
33	Pentose phosphate pathway_Homo sapiens_hsa00030	1.09583649
34	Type I diabetes mellitus_Homo sapiens_hsa04940	1.08957608
35	Viral myocarditis_Homo sapiens_hsa05416	1.08800277
36	Pyrimidine metabolism_Homo sapiens_hsa00240	1.08547168
37	Regulation of autophagy_Homo sapiens_hsa04140	1.08497450
38	Folate biosynthesis_Homo sapiens_hsa00790	1.06555285
39	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	1.06387443
40	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.05367023
41	Osteoclast differentiation_Homo sapiens_hsa04380	1.02227257
42	Peroxisome_Homo sapiens_hsa04146	1.01764030
43	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.01602680
44	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.01180845
45	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	1.00321717
46	Herpes simplex infection_Homo sapiens_hsa05168	1.00095579
47	Epstein-Barr virus infection_Homo sapiens_hsa05169	1.00011052
48	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.95357527
49	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.95030614
50	Cardiac muscle contraction_Homo sapiens_hsa04260	0.94190794
51	Fatty acid elongation_Homo sapiens_hsa00062	0.92720898
52	Antigen processing and presentation_Homo sapiens_hsa04612	0.89755660
53	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.88032540
54	Apoptosis_Homo sapiens_hsa04210	0.85342326
55	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.85332105
56	Glutathione metabolism_Homo sapiens_hsa00480	0.84879141
57	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.84189612
58	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.84117445
59	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.82906832
60	Basal transcription factors_Homo sapiens_hsa03022	0.80580075
61	Carbon metabolism_Homo sapiens_hsa01200	0.79859246
62	Tuberculosis_Homo sapiens_hsa05152	0.79690838
63	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.79018314
64	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.78962267
65	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.78094602
66	RNA degradation_Homo sapiens_hsa03018	0.76168335
67	Phagosome_Homo sapiens_hsa04145	0.76107720
68	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.76096557
69	Galactose metabolism_Homo sapiens_hsa00052	0.73187057
70	Purine metabolism_Homo sapiens_hsa00230	0.70884703
71	Acute myeloid leukemia_Homo sapiens_hsa05221	0.65895838
72	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.64416043
73	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.62475875
74	Influenza A_Homo sapiens_hsa05164	0.61664033
75	Legionellosis_Homo sapiens_hsa05134	0.61017801
76	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.60262270
77	Spliceosome_Homo sapiens_hsa03040	0.59856548
78	Hepatitis B_Homo sapiens_hsa05161	0.59694516
79	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.58954317
80	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.57797535
81	Asthma_Homo sapiens_hsa05310	0.57329640
82	Metabolic pathways_Homo sapiens_hsa01100	0.57143341
83	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.56829145
84	Shigellosis_Homo sapiens_hsa05131	0.56190935
85	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.55979116
86	Circadian rhythm_Homo sapiens_hsa04710	0.54588729
87	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.53950778
88	Nucleotide excision repair_Homo sapiens_hsa03420	0.52975563
89	RNA transport_Homo sapiens_hsa03013	0.51846623
90	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.51340489
91	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.49726260
92	Endocytosis_Homo sapiens_hsa04144	0.49170468
93	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.46848474
94	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.46353773
95	Salmonella infection_Homo sapiens_hsa05132	0.45053220
96	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.44109718
97	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.43846918
98	Chemokine signaling pathway_Homo sapiens_hsa04062	0.41378410
99	Leishmaniasis_Homo sapiens_hsa05140	0.41368265
100	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.38171283

CXORF40A

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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