

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | negative regulation of retinoic acid receptor signaling pathway (GO:0048387) | 6.29133014 |
| 2 | regulation of retinoic acid receptor signaling pathway (GO:0048385) | 5.49869266 |
| 3 | proteasome assembly (GO:0043248) | 5.29537870 |
| 4 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.54809952 |
| 5 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 4.27714043 |
| 6 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 4.25362352 |
| 7 | negative regulation of ligase activity (GO:0051352) | 4.22482297 |
| 8 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 4.22482297 |
| 9 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 4.19877289 |
| 10 | regulation of cellular amino acid metabolic process (GO:0006521) | 4.08113241 |
| 11 | chaperone-mediated protein transport (GO:0072321) | 3.95318670 |
| 12 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.91517307 |
| 13 | rRNA modification (GO:0000154) | 3.84356113 |
| 14 | protein maturation by protein folding (GO:0022417) | 3.83643128 |
| 15 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.82331650 |
| 16 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.82214813 |
| 17 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.82214813 |
| 18 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.79690848 |
| 19 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.79690848 |
| 20 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.79690848 |
| 21 | termination of RNA polymerase III transcription (GO:0006386) | 3.71610378 |
| 22 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.71610378 |
| 23 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.71168001 |
| 24 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.71168001 |
| 25 | piRNA metabolic process (GO:0034587) | 3.65325500 |
| 26 | positive regulation of ligase activity (GO:0051351) | 3.64983518 |
| 27 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.64744659 |
| 28 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.64744659 |
| 29 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.62690328 |
| 30 | ribosome assembly (GO:0042255) | 3.60142546 |
| 31 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.56314632 |
| 32 | protein targeting to mitochondrion (GO:0006626) | 3.55940111 |
| 33 | mitotic metaphase plate congression (GO:0007080) | 3.53494080 |
| 34 | DNA deamination (GO:0045006) | 3.53005581 |
| 35 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.50570149 |
| 36 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.45313646 |
| 37 | pseudouridine synthesis (GO:0001522) | 3.42823318 |
| 38 | ribosome biogenesis (GO:0042254) | 3.41987517 |
| 39 | synapsis (GO:0007129) | 3.40717699 |
| 40 | spliceosomal snRNP assembly (GO:0000387) | 3.40321478 |
| 41 | regulation of ligase activity (GO:0051340) | 3.37300312 |
| 42 | formation of translation preinitiation complex (GO:0001731) | 3.33541551 |
| 43 | meiosis I (GO:0007127) | 3.31848761 |
| 44 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.30473985 |
| 45 | regulation of mitochondrial translation (GO:0070129) | 3.28386769 |
| 46 | protein deneddylation (GO:0000338) | 3.27562022 |
| 47 | base-excision repair, AP site formation (GO:0006285) | 3.24511657 |
| 48 | establishment of protein localization to mitochondrion (GO:0072655) | 3.20093973 |
| 49 | male meiosis I (GO:0007141) | 3.19466296 |
| 50 | protein localization to mitochondrion (GO:0070585) | 3.19251982 |
| 51 | rRNA methylation (GO:0031167) | 3.18552175 |
| 52 | CENP-A containing nucleosome assembly (GO:0034080) | 3.16105968 |
| 53 | negative regulation of protein ubiquitination (GO:0031397) | 3.14248014 |
| 54 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 3.11404678 |
| 55 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.09565952 |
| 56 | cullin deneddylation (GO:0010388) | 3.09233349 |
| 57 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 3.07191433 |
| 58 | activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO | 3.07122124 |
| 59 | negative regulation of protein modification by small protein conjugation or removal (GO:1903321) | 3.02017481 |
| 60 | regulation of cellular amine metabolic process (GO:0033238) | 3.01477555 |
| 61 | positive regulation of cell cycle arrest (GO:0071158) | 3.01328863 |
| 62 | maturation of SSU-rRNA (GO:0030490) | 2.98061877 |
| 63 | inner mitochondrial membrane organization (GO:0007007) | 2.97865862 |
| 64 | rRNA processing (GO:0006364) | 2.97319373 |
| 65 | chromatin remodeling at centromere (GO:0031055) | 2.96716988 |
| 66 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 2.96503135 |
| 67 | male meiosis (GO:0007140) | 2.90770128 |
| 68 | ribonucleoprotein complex biogenesis (GO:0022613) | 2.89794253 |
| 69 | pyrimidine nucleotide catabolic process (GO:0006244) | 2.88847118 |
| 70 | DNA methylation involved in gamete generation (GO:0043046) | 2.87270246 |
| 71 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 2.85921988 |
| 72 | polyamine biosynthetic process (GO:0006596) | 2.85135546 |
| 73 | G1/S transition of mitotic cell cycle (GO:0000082) | 2.83659563 |
| 74 | cell cycle G1/S phase transition (GO:0044843) | 2.83659563 |
| 75 | folic acid-containing compound biosynthetic process (GO:0009396) | 2.81335992 |
| 76 | metaphase plate congression (GO:0051310) | 2.81191247 |
| 77 | rRNA metabolic process (GO:0016072) | 2.79945581 |
| 78 | pentose metabolic process (GO:0019321) | 2.78980117 |
| 79 | de novo protein folding (GO:0006458) | 2.78184992 |
| 80 | 7-methylguanosine mRNA capping (GO:0006370) | 2.77042498 |
| 81 | establishment of viral latency (GO:0019043) | 2.75954459 |
| 82 | metallo-sulfur cluster assembly (GO:0031163) | 2.74397911 |
| 83 | iron-sulfur cluster assembly (GO:0016226) | 2.74397911 |
| 84 | DNA catabolic process, exonucleolytic (GO:0000738) | 2.73590119 |
| 85 | peptidyl-arginine omega-N-methylation (GO:0035247) | 2.73261121 |
| 86 | telomere maintenance via semi-conservative replication (GO:0032201) | 2.72833537 |
| 87 | de novo posttranslational protein folding (GO:0051084) | 2.71714709 |
| 88 | transcription from mitochondrial promoter (GO:0006390) | 2.71038135 |
| 89 | mitochondrial RNA metabolic process (GO:0000959) | 2.70824290 |
| 90 | deoxyribonucleotide catabolic process (GO:0009264) | 2.68133540 |
| 91 | establishment of integrated proviral latency (GO:0075713) | 2.67487781 |
| 92 | 7-methylguanosine RNA capping (GO:0009452) | 2.67157612 |
| 93 | RNA capping (GO:0036260) | 2.67157612 |
| 94 | negative regulation of release of cytochrome c from mitochondria (GO:0090201) | 2.66913037 |
| 95 | transcription elongation from RNA polymerase II promoter (GO:0006368) | 2.66753325 |
| 96 | histone mRNA metabolic process (GO:0008334) | 2.66541459 |
| 97 | histone exchange (GO:0043486) | 2.63447019 |
| 98 | transcription-coupled nucleotide-excision repair (GO:0006283) | 2.63301575 |
| 99 | respiratory electron transport chain (GO:0022904) | 2.62323786 |
| 100 | cellular component biogenesis (GO:0044085) | 2.62249854 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 4.43638145 |
| 2 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.26087143 |
| 3 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.65878490 |
| 4 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.62579328 |
| 5 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.53831184 |
| 6 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.42056884 |
| 7 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.27581765 |
| 8 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.21061826 |
| 9 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.14631085 |
| 10 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 3.04046252 |
| 11 | * ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.03354199 |
| 12 | E2F7_22180533_ChIP-Seq_HELA_Human | 3.03182359 |
| 13 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 2.94938136 |
| 14 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.82842614 |
| 15 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.74661150 |
| 16 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.73852110 |
| 17 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.48698906 |
| 18 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.44682426 |
| 19 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.39457889 |
| 20 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.34408444 |
| 21 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.29528710 |
| 22 | GABP_19822575_ChIP-Seq_HepG2_Human | 2.26839791 |
| 23 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 2.26808617 |
| 24 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.25359730 |
| 25 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.22567925 |
| 26 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.21344164 |
| 27 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.16729069 |
| 28 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.15713449 |
| 29 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.11995433 |
| 30 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.02009491 |
| 31 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.98593095 |
| 32 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.89079134 |
| 33 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.87949635 |
| 34 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.87079024 |
| 35 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.83193203 |
| 36 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.79745747 |
| 37 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.73754790 |
| 38 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.73616221 |
| 39 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.72025262 |
| 40 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.71941786 |
| 41 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.70068113 |
| 42 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.68658025 |
| 43 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.67524161 |
| 44 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.64747030 |
| 45 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.63982076 |
| 46 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.62851565 |
| 47 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.62593205 |
| 48 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.62165833 |
| 49 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.59706098 |
| 50 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.57427243 |
| 51 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.56696782 |
| 52 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.52931671 |
| 53 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.48036730 |
| 54 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.43019103 |
| 55 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.40304704 |
| 56 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.38725414 |
| 57 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.36835330 |
| 58 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.34582435 |
| 59 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.34018587 |
| 60 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.32653722 |
| 61 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.26109564 |
| 62 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.26107337 |
| 63 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.25568178 |
| 64 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.25536777 |
| 65 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.24345665 |
| 66 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.23428781 |
| 67 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 1.22812669 |
| 68 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.19618367 |
| 69 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.17504341 |
| 70 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.11728081 |
| 71 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 1.11134426 |
| 72 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.08252935 |
| 73 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.07295002 |
| 74 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 1.06857138 |
| 75 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.05492754 |
| 76 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.04790886 |
| 77 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.02699485 |
| 78 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.01596544 |
| 79 | CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.99318911 |
| 80 | SPI1_23547873_ChIP-Seq_NB4_Human | 0.99114235 |
| 81 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.99079269 |
| 82 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.97456989 |
| 83 | TBX5_21415370_ChIP-Seq_HL-1_Mouse | 0.96084966 |
| 84 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 0.94811613 |
| 85 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.92364009 |
| 86 | AR_21909140_ChIP-Seq_LNCAP_Human | 0.90226547 |
| 87 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 0.88098234 |
| 88 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 0.87938500 |
| 89 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.87877416 |
| 90 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.86673448 |
| 91 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.86434138 |
| 92 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.86146266 |
| 93 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 0.86092165 |
| 94 | MAF_26560356_Chip-Seq_TH2_Human | 0.83375621 |
| 95 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.83000487 |
| 96 | VDR_21846776_ChIP-Seq_THP-1_Human | 0.82814216 |
| 97 | MYC_22102868_ChIP-Seq_BL_Human | 0.81247385 |
| 98 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 0.81222542 |
| 99 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 0.80468615 |
| 100 | TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse | 0.80459716 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 4.42091599 |
| 2 | MP0008058_abnormal_DNA_repair | 4.01047561 |
| 3 | MP0003111_abnormal_nucleus_morphology | 3.60766388 |
| 4 | MP0004957_abnormal_blastocyst_morpholog | 3.37542154 |
| 5 | MP0003806_abnormal_nucleotide_metabolis | 3.32826169 |
| 6 | MP0003077_abnormal_cell_cycle | 2.98730687 |
| 7 | MP0010094_abnormal_chromosome_stability | 2.96980263 |
| 8 | MP0003786_premature_aging | 2.84603099 |
| 9 | MP0003718_maternal_effect | 2.76767381 |
| 10 | MP0008260_abnormal_autophagy | 2.67827902 |
| 11 | MP0003186_abnormal_redox_activity | 2.66096054 |
| 12 | MP0009333_abnormal_splenocyte_physiolog | 2.54426069 |
| 13 | MP0006036_abnormal_mitochondrial_physio | 2.54124709 |
| 14 | MP0008932_abnormal_embryonic_tissue | 2.39353239 |
| 15 | MP0006035_abnormal_mitochondrial_morpho | 2.39224713 |
| 16 | MP0008007_abnormal_cellular_replicative | 2.38184129 |
| 17 | MP0005058_abnormal_lysosome_morphology | 2.19384455 |
| 18 | MP0008877_abnormal_DNA_methylation | 2.14904369 |
| 19 | MP0002210_abnormal_sex_determination | 1.85915801 |
| 20 | MP0001730_embryonic_growth_arrest | 1.83128981 |
| 21 | MP0009697_abnormal_copulation | 1.72658342 |
| 22 | MP0001853_heart_inflammation | 1.72279092 |
| 23 | MP0000358_abnormal_cell_content/ | 1.70223000 |
| 24 | MP0008995_early_reproductive_senescence | 1.69279143 |
| 25 | MP0001929_abnormal_gametogenesis | 1.65923897 |
| 26 | MP0008789_abnormal_olfactory_epithelium | 1.62559846 |
| 27 | MP0000372_irregular_coat_pigmentation | 1.57065800 |
| 28 | MP0000313_abnormal_cell_death | 1.51630624 |
| 29 | MP0000350_abnormal_cell_proliferation | 1.50057221 |
| 30 | MP0001727_abnormal_embryo_implantation | 1.47458391 |
| 31 | MP0001764_abnormal_homeostasis | 1.44747578 |
| 32 | MP0002148_abnormal_hypersensitivity_rea | 1.43215116 |
| 33 | MP0002396_abnormal_hematopoietic_system | 1.41923878 |
| 34 | MP0005394_taste/olfaction_phenotype | 1.39399069 |
| 35 | MP0005499_abnormal_olfactory_system | 1.39399069 |
| 36 | MP0002877_abnormal_melanocyte_morpholog | 1.36225541 |
| 37 | MP0001145_abnormal_male_reproductive | 1.36018014 |
| 38 | MP0002132_abnormal_respiratory_system | 1.35451956 |
| 39 | MP0000653_abnormal_sex_gland | 1.31462030 |
| 40 | MP0005671_abnormal_response_to | 1.26115002 |
| 41 | MP0000678_abnormal_parathyroid_gland | 1.23772402 |
| 42 | MP0003763_abnormal_thymus_physiology | 1.22518500 |
| 43 | MP0002019_abnormal_tumor_incidence | 1.20787468 |
| 44 | MP0000703_abnormal_thymus_morphology | 1.20168664 |
| 45 | MP0005451_abnormal_body_composition | 1.18099106 |
| 46 | MP0010307_abnormal_tumor_latency | 1.16102547 |
| 47 | MP0002080_prenatal_lethality | 1.15543261 |
| 48 | MP0002160_abnormal_reproductive_system | 1.12097444 |
| 49 | MP0008004_abnormal_stomach_pH | 1.12012772 |
| 50 | MP0005410_abnormal_fertilization | 1.09345758 |
| 51 | MP0009840_abnormal_foam_cell | 1.09150234 |
| 52 | MP0002277_abnormal_respiratory_mucosa | 1.08474119 |
| 53 | MP0002722_abnormal_immune_system | 1.08360919 |
| 54 | MP0005395_other_phenotype | 1.08319287 |
| 55 | MP0000858_altered_metastatic_potential | 1.08049346 |
| 56 | MP0002398_abnormal_bone_marrow | 1.07982316 |
| 57 | MP0005380_embryogenesis_phenotype | 1.06972927 |
| 58 | MP0001672_abnormal_embryogenesis/_devel | 1.06972927 |
| 59 | MP0001697_abnormal_embryo_size | 1.05424233 |
| 60 | MP0001661_extended_life_span | 1.05418428 |
| 61 | MP0005075_abnormal_melanosome_morpholog | 1.04861712 |
| 62 | MP0000490_abnormal_crypts_of | 1.02487397 |
| 63 | MP0005501_abnormal_skin_physiology | 1.02280848 |
| 64 | MP0000689_abnormal_spleen_morphology | 1.01346336 |
| 65 | MP0009785_altered_susceptibility_to | 1.00912100 |
| 66 | MP0003699_abnormal_female_reproductive | 0.99801711 |
| 67 | MP0002796_impaired_skin_barrier | 0.97342455 |
| 68 | MP0002429_abnormal_blood_cell | 0.94798744 |
| 69 | MP0003698_abnormal_male_reproductive | 0.92539579 |
| 70 | MP0002161_abnormal_fertility/fecundity | 0.91857967 |
| 71 | MP0000015_abnormal_ear_pigmentation | 0.91818391 |
| 72 | MP0001119_abnormal_female_reproductive | 0.90023034 |
| 73 | MP0005319_abnormal_enzyme/_coenzyme | 0.89569138 |
| 74 | MP0005384_cellular_phenotype | 0.89225617 |
| 75 | MP0005000_abnormal_immune_tolerance | 0.89111255 |
| 76 | MP0001188_hyperpigmentation | 0.87996633 |
| 77 | MP0000343_altered_response_to | 0.85666107 |
| 78 | MP0005464_abnormal_platelet_physiology | 0.85316551 |
| 79 | MP0002420_abnormal_adaptive_immunity | 0.85303635 |
| 80 | MP0001881_abnormal_mammary_gland | 0.84889133 |
| 81 | MP0008057_abnormal_DNA_replication | 0.83190051 |
| 82 | MP0000716_abnormal_immune_system | 0.82996533 |
| 83 | MP0001819_abnormal_immune_cell | 0.82646546 |
| 84 | MP0002736_abnormal_nociception_after | 0.82465468 |
| 85 | MP0002723_abnormal_immune_serum | 0.81931983 |
| 86 | MP0003984_embryonic_growth_retardation | 0.81389977 |
| 87 | MP0003941_abnormal_skin_development | 0.80067706 |
| 88 | MP0005670_abnormal_white_adipose | 0.77568484 |
| 89 | MP0001529_abnormal_vocalization | 0.77185234 |
| 90 | MP0004381_abnormal_hair_follicle | 0.77148484 |
| 91 | MP0008873_increased_physiological_sensi | 0.76683765 |
| 92 | MP0001873_stomach_inflammation | 0.75994856 |
| 93 | MP0002452_abnormal_antigen_presenting | 0.75570252 |
| 94 | MP0006082_CNS_inflammation | 0.75450273 |
| 95 | MP0002088_abnormal_embryonic_growth/wei | 0.75012372 |
| 96 | MP0005408_hypopigmentation | 0.73669274 |
| 97 | MP0001243_abnormal_dermal_layer | 0.71876024 |
| 98 | MP0004233_abnormal_muscle_weight | 0.71734981 |
| 99 | MP0005621_abnormal_cell_physiology | 0.70820575 |
| 100 | MP0010030_abnormal_orbit_morphology | 0.70441981 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Cholecystitis (HP:0001082) | 4.22864684 |
| 2 | Abnormal gallbladder physiology (HP:0012438) | 4.22864684 |
| 3 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 4.12267813 |
| 4 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 4.12267813 |
| 5 | Acute necrotizing encephalopathy (HP:0006965) | 3.81512616 |
| 6 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.81411343 |
| 7 | Microvesicular hepatic steatosis (HP:0001414) | 3.66291668 |
| 8 | Increased serum pyruvate (HP:0003542) | 3.33464545 |
| 9 | Abnormal umbilical cord blood vessels (HP:0011403) | 3.29589915 |
| 10 | Single umbilical artery (HP:0001195) | 3.29589915 |
| 11 | Abnormality of the fetal cardiovascular system (HP:0010948) | 3.29589915 |
| 12 | Acute encephalopathy (HP:0006846) | 3.27513503 |
| 13 | Mitochondrial inheritance (HP:0001427) | 3.23665184 |
| 14 | Premature ovarian failure (HP:0008209) | 3.23028998 |
| 15 | Abnormality of glycolysis (HP:0004366) | 3.18076296 |
| 16 | Type I transferrin isoform profile (HP:0003642) | 3.14786388 |
| 17 | Increased CSF lactate (HP:0002490) | 3.13896600 |
| 18 | Cerebral hypomyelination (HP:0006808) | 3.13335773 |
| 19 | Rough bone trabeculation (HP:0100670) | 3.06407333 |
| 20 | Abnormality of alanine metabolism (HP:0010916) | 3.00771965 |
| 21 | Hyperalaninemia (HP:0003348) | 3.00771965 |
| 22 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 3.00771965 |
| 23 | Microretrognathia (HP:0000308) | 2.92994207 |
| 24 | Progressive macrocephaly (HP:0004481) | 2.92847050 |
| 25 | Hepatocellular necrosis (HP:0001404) | 2.92758852 |
| 26 | Abnormal protein glycosylation (HP:0012346) | 2.92572965 |
| 27 | Abnormal glycosylation (HP:0012345) | 2.92572965 |
| 28 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.92572965 |
| 29 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.92572965 |
| 30 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.92153048 |
| 31 | Increased serum lactate (HP:0002151) | 2.87368118 |
| 32 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.86890198 |
| 33 | Lactic acidosis (HP:0003128) | 2.82408735 |
| 34 | Hepatic necrosis (HP:0002605) | 2.81007189 |
| 35 | Degeneration of anterior horn cells (HP:0002398) | 2.79209361 |
| 36 | Abnormality of the anterior horn cell (HP:0006802) | 2.79209361 |
| 37 | Generalized aminoaciduria (HP:0002909) | 2.75282695 |
| 38 | Abnormality of the umbilical cord (HP:0010881) | 2.69983758 |
| 39 | Exercise intolerance (HP:0003546) | 2.68890971 |
| 40 | Nausea (HP:0002018) | 2.68278529 |
| 41 | Cerebral edema (HP:0002181) | 2.66211765 |
| 42 | Aplastic anemia (HP:0001915) | 2.65456044 |
| 43 | Reduced antithrombin III activity (HP:0001976) | 2.64239431 |
| 44 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.62393994 |
| 45 | Increased intramyocellular lipid droplets (HP:0012240) | 2.59872212 |
| 46 | Abnormality of lateral ventricle (HP:0030047) | 2.58230673 |
| 47 | Renal Fanconi syndrome (HP:0001994) | 2.57313610 |
| 48 | Hypokinesia (HP:0002375) | 2.57157787 |
| 49 | Secondary amenorrhea (HP:0000869) | 2.54233426 |
| 50 | Abnormal trabecular bone morphology (HP:0100671) | 2.49434471 |
| 51 | Oral leukoplakia (HP:0002745) | 2.45445431 |
| 52 | 3-Methylglutaconic aciduria (HP:0003535) | 2.45158750 |
| 53 | Reticulocytopenia (HP:0001896) | 2.43194183 |
| 54 | Carpal bone hypoplasia (HP:0001498) | 2.41254805 |
| 55 | Multiple enchondromatosis (HP:0005701) | 2.33399286 |
| 56 | Progressive muscle weakness (HP:0003323) | 2.32209705 |
| 57 | Ragged-red muscle fibers (HP:0003200) | 2.30684740 |
| 58 | Increased muscle lipid content (HP:0009058) | 2.27125386 |
| 59 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.23288031 |
| 60 | Horseshoe kidney (HP:0000085) | 2.22118689 |
| 61 | Increased hepatocellular lipid droplets (HP:0006565) | 2.18391812 |
| 62 | Fatigue (HP:0012378) | 2.17516916 |
| 63 | Sparse eyelashes (HP:0000653) | 2.14308935 |
| 64 | Respiratory failure (HP:0002878) | 2.11577947 |
| 65 | Chromsome breakage (HP:0040012) | 2.07605614 |
| 66 | CNS hypomyelination (HP:0003429) | 2.05109653 |
| 67 | Respiratory difficulties (HP:0002880) | 2.04133166 |
| 68 | Pancytopenia (HP:0001876) | 2.03746224 |
| 69 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 2.00927759 |
| 70 | Abnormalities of placenta or umbilical cord (HP:0001194) | 2.00142655 |
| 71 | Lipid accumulation in hepatocytes (HP:0006561) | 1.99370930 |
| 72 | Abnormality of the preputium (HP:0100587) | 1.97880795 |
| 73 | Delusions (HP:0000746) | 1.94175967 |
| 74 | Cortical visual impairment (HP:0100704) | 1.93671076 |
| 75 | Progressive external ophthalmoplegia (HP:0000590) | 1.93228841 |
| 76 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.90313038 |
| 77 | Postnatal microcephaly (HP:0005484) | 1.90054541 |
| 78 | Cholelithiasis (HP:0001081) | 1.88709395 |
| 79 | Congenital ichthyosiform erythroderma (HP:0007431) | 1.88209978 |
| 80 | Testicular atrophy (HP:0000029) | 1.87708462 |
| 81 | Abnormal number of erythroid precursors (HP:0012131) | 1.87410235 |
| 82 | Increased IgM level (HP:0003496) | 1.85688101 |
| 83 | X-linked dominant inheritance (HP:0001423) | 1.84705576 |
| 84 | Hepatosplenomegaly (HP:0001433) | 1.84027336 |
| 85 | Unsteady gait (HP:0002317) | 1.83364924 |
| 86 | Lethargy (HP:0001254) | 1.82292410 |
| 87 | Cleft eyelid (HP:0000625) | 1.80159573 |
| 88 | Trismus (HP:0000211) | 1.79675567 |
| 89 | J-shaped sella turcica (HP:0002680) | 1.78924744 |
| 90 | Bone marrow hypocellularity (HP:0005528) | 1.78488549 |
| 91 | Abnormal lung lobation (HP:0002101) | 1.78110540 |
| 92 | Hypergonadotropic hypogonadism (HP:0000815) | 1.76834139 |
| 93 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 1.76749240 |
| 94 | Short tibia (HP:0005736) | 1.76346323 |
| 95 | Abnormality of methionine metabolism (HP:0010901) | 1.74101383 |
| 96 | Abnormal gallbladder morphology (HP:0012437) | 1.74065613 |
| 97 | Ureteral duplication (HP:0000073) | 1.73611375 |
| 98 | Abnormality of the labia minora (HP:0012880) | 1.72449711 |
| 99 | Death in infancy (HP:0001522) | 1.72429818 |
| 100 | Emotional lability (HP:0000712) | 1.72310432 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BUB1 | 4.76255550 |
| 2 | NME2 | 4.67683249 |
| 3 | VRK2 | 3.54281050 |
| 4 | TESK2 | 3.42470886 |
| 5 | STK16 | 3.40952418 |
| 6 | PBK | 3.11382213 |
| 7 | SRPK1 | 2.96725835 |
| 8 | TRIM28 | 2.79082787 |
| 9 | PDK2 | 2.63947996 |
| 10 | ARAF | 2.40343131 |
| 11 | MST4 | 2.38429578 |
| 12 | EIF2AK1 | 2.35344897 |
| 13 | EIF2AK3 | 2.30313498 |
| 14 | IRAK3 | 2.24478777 |
| 15 | BCKDK | 2.19067733 |
| 16 | TTK | 1.84179542 |
| 17 | MAP3K3 | 1.83658276 |
| 18 | TESK1 | 1.73609075 |
| 19 | KDR | 1.58369183 |
| 20 | NEK1 | 1.51378008 |
| 21 | NME1 | 1.51039960 |
| 22 | SIK3 | 1.50762351 |
| 23 | TXK | 1.50015708 |
| 24 | PIM2 | 1.49245291 |
| 25 | VRK1 | 1.34538269 |
| 26 | MARK3 | 1.26499987 |
| 27 | TAOK2 | 1.24218975 |
| 28 | BRAF | 1.14529183 |
| 29 | NUAK1 | 1.14426135 |
| 30 | BRSK1 | 1.10789261 |
| 31 | ZAK | 1.09775625 |
| 32 | CCNB1 | 1.08888938 |
| 33 | PLK1 | 1.08547838 |
| 34 | MAP2K3 | 1.08116132 |
| 35 | CDK19 | 1.07385837 |
| 36 | PAK4 | 1.07193973 |
| 37 | MAP4K2 | 1.06302477 |
| 38 | PLK3 | 1.01460033 |
| 39 | RAF1 | 0.99431281 |
| 40 | SMG1 | 0.98658308 |
| 41 | TBK1 | 0.93118831 |
| 42 | PRKCI | 0.92576667 |
| 43 | PAK1 | 0.91087636 |
| 44 | AURKA | 0.89630505 |
| 45 | CLK1 | 0.86588046 |
| 46 | CDC7 | 0.84545244 |
| 47 | IRAK2 | 0.83527933 |
| 48 | MAP3K5 | 0.79641288 |
| 49 | CDK9 | 0.79574426 |
| 50 | LRRK2 | 0.79344546 |
| 51 | ATR | 0.76695333 |
| 52 | AURKB | 0.75197240 |
| 53 | MAP4K1 | 0.74576537 |
| 54 | ILK | 0.73386334 |
| 55 | MAP3K8 | 0.72676251 |
| 56 | CDK7 | 0.72035746 |
| 57 | TSSK6 | 0.66811301 |
| 58 | CSNK1G3 | 0.66621453 |
| 59 | STK10 | 0.64328255 |
| 60 | STK4 | 0.63711358 |
| 61 | CHEK1 | 0.61543042 |
| 62 | DAPK1 | 0.60418426 |
| 63 | PRPF4B | 0.59804657 |
| 64 | RPS6KB2 | 0.58509548 |
| 65 | EPHA2 | 0.57897026 |
| 66 | PLK4 | 0.57672635 |
| 67 | LIMK1 | 0.57309167 |
| 68 | CSNK2A1 | 0.56596796 |
| 69 | IKBKB | 0.56017138 |
| 70 | BRSK2 | 0.54097275 |
| 71 | RPS6KA5 | 0.52511882 |
| 72 | BCR | 0.49664187 |
| 73 | ABL2 | 0.49647353 |
| 74 | CSNK2A2 | 0.48551044 |
| 75 | CHEK2 | 0.46953313 |
| 76 | NEK6 | 0.44860559 |
| 77 | DYRK3 | 0.44706266 |
| 78 | WEE1 | 0.41170142 |
| 79 | IRAK4 | 0.41000296 |
| 80 | BMX | 0.39656990 |
| 81 | EIF2AK2 | 0.38885909 |
| 82 | AKT2 | 0.38822624 |
| 83 | FGR | 0.38141980 |
| 84 | PRKCQ | 0.35856270 |
| 85 | JAK3 | 0.35572332 |
| 86 | CSNK1A1L | 0.35390060 |
| 87 | RPS6KA4 | 0.35373162 |
| 88 | MKNK1 | 0.34642768 |
| 89 | CDK8 | 0.33704649 |
| 90 | MAP3K9 | 0.33653039 |
| 91 | CSNK1G1 | 0.32483021 |
| 92 | MAPKAPK2 | 0.28276509 |
| 93 | MYLK | 0.26865960 |
| 94 | MAP2K7 | 0.26213969 |
| 95 | CDK2 | 0.25874818 |
| 96 | MST1R | 0.25578234 |
| 97 | ATM | 0.25314633 |
| 98 | ALK | 0.24985458 |
| 99 | MAP3K12 | 0.24268338 |
| 100 | MOS | 0.23419351 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 5.30726036 |
| 2 | DNA replication_Homo sapiens_hsa03030 | 3.17620501 |
| 3 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.10618563 |
| 4 | RNA polymerase_Homo sapiens_hsa03020 | 3.08818568 |
| 5 | Mismatch repair_Homo sapiens_hsa03430 | 2.85777876 |
| 6 | Base excision repair_Homo sapiens_hsa03410 | 2.78901285 |
| 7 | Ribosome_Homo sapiens_hsa03010 | 2.64884913 |
| 8 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.58968393 |
| 9 | Parkinsons disease_Homo sapiens_hsa05012 | 2.48425554 |
| 10 | Spliceosome_Homo sapiens_hsa03040 | 2.38055768 |
| 11 | RNA transport_Homo sapiens_hsa03013 | 2.24264699 |
| 12 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.09553296 |
| 13 | Sulfur relay system_Homo sapiens_hsa04122 | 2.01598905 |
| 14 | Basal transcription factors_Homo sapiens_hsa03022 | 1.97317194 |
| 15 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.96547255 |
| 16 | Huntingtons disease_Homo sapiens_hsa05016 | 1.78910543 |
| 17 | Protein export_Homo sapiens_hsa03060 | 1.77998310 |
| 18 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.76062623 |
| 19 | Homologous recombination_Homo sapiens_hsa03440 | 1.75858425 |
| 20 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.71483349 |
| 21 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.70607831 |
| 22 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.62264987 |
| 23 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.60624486 |
| 24 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.57353853 |
| 25 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.49413466 |
| 26 | Cell cycle_Homo sapiens_hsa04110 | 1.49226507 |
| 27 | RNA degradation_Homo sapiens_hsa03018 | 1.38948860 |
| 28 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.37098529 |
| 29 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.36400238 |
| 30 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.36293382 |
| 31 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.21686213 |
| 32 | Alzheimers disease_Homo sapiens_hsa05010 | 1.21556886 |
| 33 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.20984349 |
| 34 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.19385221 |
| 35 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.18239934 |
| 36 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.17543821 |
| 37 | Purine metabolism_Homo sapiens_hsa00230 | 1.16084449 |
| 38 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.14048767 |
| 39 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.11737122 |
| 40 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.11009207 |
| 41 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.09165307 |
| 42 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.06611541 |
| 43 | Carbon metabolism_Homo sapiens_hsa01200 | 1.06309634 |
| 44 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.03226700 |
| 45 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.02080398 |
| 46 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.99255468 |
| 47 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.98941792 |
| 48 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.96713202 |
| 49 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.93026890 |
| 50 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.92416958 |
| 51 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.91964226 |
| 52 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.91490666 |
| 53 | Galactose metabolism_Homo sapiens_hsa00052 | 0.88600947 |
| 54 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.87180951 |
| 55 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.86619177 |
| 56 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.83972571 |
| 57 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.83643238 |
| 58 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.82812657 |
| 59 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.79069713 |
| 60 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.78574983 |
| 61 | Shigellosis_Homo sapiens_hsa05131 | 0.72725485 |
| 62 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.70653952 |
| 63 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.69621152 |
| 64 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.68452385 |
| 65 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.63643618 |
| 66 | Metabolic pathways_Homo sapiens_hsa01100 | 0.63453349 |
| 67 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.58623376 |
| 68 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.58298886 |
| 69 | Legionellosis_Homo sapiens_hsa05134 | 0.58127477 |
| 70 | Other glycan degradation_Homo sapiens_hsa00511 | 0.58070448 |
| 71 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.56175577 |
| 72 | Apoptosis_Homo sapiens_hsa04210 | 0.54505013 |
| 73 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.54399929 |
| 74 | Salmonella infection_Homo sapiens_hsa05132 | 0.53701320 |
| 75 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.48696444 |
| 76 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.48215407 |
| 77 | Lysosome_Homo sapiens_hsa04142 | 0.45050889 |
| 78 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.43813464 |
| 79 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.41877238 |
| 80 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.40727078 |
| 81 | Measles_Homo sapiens_hsa05162 | 0.38209851 |
| 82 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.37049004 |
| 83 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.36033766 |
| 84 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.35878944 |
| 85 | Peroxisome_Homo sapiens_hsa04146 | 0.35559619 |
| 86 | HTLV-I infection_Homo sapiens_hsa05166 | 0.35332222 |
| 87 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.32245729 |
| 88 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.29184798 |
| 89 | Allograft rejection_Homo sapiens_hsa05330 | 0.27650478 |
| 90 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.27606400 |
| 91 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.26231921 |
| 92 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.22225208 |
| 93 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.22113443 |
| 94 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.21363559 |
| 95 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.17008871 |
| 96 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.16674804 |
| 97 | Influenza A_Homo sapiens_hsa05164 | 0.16370392 |
| 98 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.13837119 |
| 99 | Thyroid cancer_Homo sapiens_hsa05216 | 0.13722297 |
| 100 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.12091227 |

