CXORF40B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of retinoic acid receptor signaling pathway (GO:0048387)6.29133014
2regulation of retinoic acid receptor signaling pathway (GO:0048385)5.49869266
3proteasome assembly (GO:0043248)5.29537870
4negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.54809952
5regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.27714043
6positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.25362352
7negative regulation of ligase activity (GO:0051352)4.22482297
8negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.22482297
9anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.19877289
10regulation of cellular amino acid metabolic process (GO:0006521)4.08113241
11chaperone-mediated protein transport (GO:0072321)3.95318670
12DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.91517307
13rRNA modification (GO:0000154)3.84356113
14protein maturation by protein folding (GO:0022417)3.83643128
15positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.82331650
16intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.82214813
17signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.82214813
18signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.79690848
19signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.79690848
20signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.79690848
21termination of RNA polymerase III transcription (GO:0006386)3.71610378
22transcription elongation from RNA polymerase III promoter (GO:0006385)3.71610378
23signal transduction involved in DNA damage checkpoint (GO:0072422)3.71168001
24signal transduction involved in DNA integrity checkpoint (GO:0072401)3.71168001
25piRNA metabolic process (GO:0034587)3.65325500
26positive regulation of ligase activity (GO:0051351)3.64983518
27RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.64744659
28tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.64744659
29signal transduction involved in cell cycle checkpoint (GO:0072395)3.62690328
30ribosome assembly (GO:0042255)3.60142546
31pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.56314632
32protein targeting to mitochondrion (GO:0006626)3.55940111
33mitotic metaphase plate congression (GO:0007080)3.53494080
34DNA deamination (GO:0045006)3.53005581
35regulation of ubiquitin-protein transferase activity (GO:0051438)3.50570149
36establishment of protein localization to mitochondrial membrane (GO:0090151)3.45313646
37pseudouridine synthesis (GO:0001522)3.42823318
38ribosome biogenesis (GO:0042254)3.41987517
39synapsis (GO:0007129)3.40717699
40spliceosomal snRNP assembly (GO:0000387)3.40321478
41regulation of ligase activity (GO:0051340)3.37300312
42formation of translation preinitiation complex (GO:0001731)3.33541551
43meiosis I (GO:0007127)3.31848761
44antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.30473985
45regulation of mitochondrial translation (GO:0070129)3.28386769
46protein deneddylation (GO:0000338)3.27562022
47base-excision repair, AP site formation (GO:0006285)3.24511657
48establishment of protein localization to mitochondrion (GO:0072655)3.20093973
49male meiosis I (GO:0007141)3.19466296
50protein localization to mitochondrion (GO:0070585)3.19251982
51rRNA methylation (GO:0031167)3.18552175
52CENP-A containing nucleosome assembly (GO:0034080)3.16105968
53negative regulation of protein ubiquitination (GO:0031397)3.14248014
54pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.11404678
55deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.09565952
56cullin deneddylation (GO:0010388)3.09233349
57antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.07191433
58activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO3.07122124
59negative regulation of protein modification by small protein conjugation or removal (GO:1903321)3.02017481
60regulation of cellular amine metabolic process (GO:0033238)3.01477555
61positive regulation of cell cycle arrest (GO:0071158)3.01328863
62maturation of SSU-rRNA (GO:0030490)2.98061877
63inner mitochondrial membrane organization (GO:0007007)2.97865862
64rRNA processing (GO:0006364)2.97319373
65chromatin remodeling at centromere (GO:0031055)2.96716988
66mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.96503135
67male meiosis (GO:0007140)2.90770128
68ribonucleoprotein complex biogenesis (GO:0022613)2.89794253
69pyrimidine nucleotide catabolic process (GO:0006244)2.88847118
70DNA methylation involved in gamete generation (GO:0043046)2.87270246
71DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.85921988
72polyamine biosynthetic process (GO:0006596)2.85135546
73G1/S transition of mitotic cell cycle (GO:0000082)2.83659563
74cell cycle G1/S phase transition (GO:0044843)2.83659563
75folic acid-containing compound biosynthetic process (GO:0009396)2.81335992
76metaphase plate congression (GO:0051310)2.81191247
77rRNA metabolic process (GO:0016072)2.79945581
78pentose metabolic process (GO:0019321)2.78980117
79de novo protein folding (GO:0006458)2.78184992
807-methylguanosine mRNA capping (GO:0006370)2.77042498
81establishment of viral latency (GO:0019043)2.75954459
82metallo-sulfur cluster assembly (GO:0031163)2.74397911
83iron-sulfur cluster assembly (GO:0016226)2.74397911
84DNA catabolic process, exonucleolytic (GO:0000738)2.73590119
85peptidyl-arginine omega-N-methylation (GO:0035247)2.73261121
86telomere maintenance via semi-conservative replication (GO:0032201)2.72833537
87de novo posttranslational protein folding (GO:0051084)2.71714709
88transcription from mitochondrial promoter (GO:0006390)2.71038135
89mitochondrial RNA metabolic process (GO:0000959)2.70824290
90deoxyribonucleotide catabolic process (GO:0009264)2.68133540
91establishment of integrated proviral latency (GO:0075713)2.67487781
927-methylguanosine RNA capping (GO:0009452)2.67157612
93RNA capping (GO:0036260)2.67157612
94negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.66913037
95transcription elongation from RNA polymerase II promoter (GO:0006368)2.66753325
96histone mRNA metabolic process (GO:0008334)2.66541459
97histone exchange (GO:0043486)2.63447019
98transcription-coupled nucleotide-excision repair (GO:0006283)2.63301575
99respiratory electron transport chain (GO:0022904)2.62323786
100cellular component biogenesis (GO:0044085)2.62249854

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.43638145
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.26087143
3JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.65878490
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.62579328
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.53831184
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.42056884
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.27581765
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.21061826
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.14631085
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.04046252
11* ETS1_20019798_ChIP-Seq_JURKAT_Human3.03354199
12E2F7_22180533_ChIP-Seq_HELA_Human3.03182359
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.94938136
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.82842614
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.74661150
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.73852110
17MYC_19030024_ChIP-ChIP_MESCs_Mouse2.48698906
18DCP1A_22483619_ChIP-Seq_HELA_Human2.44682426
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.39457889
20THAP11_20581084_ChIP-Seq_MESCs_Mouse2.34408444
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.29528710
22GABP_19822575_ChIP-Seq_HepG2_Human2.26839791
23TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.26808617
24FOXP3_21729870_ChIP-Seq_TREG_Human2.25359730
25MYC_19079543_ChIP-ChIP_MESCs_Mouse2.22567925
26VDR_23849224_ChIP-Seq_CD4+_Human2.21344164
27NELFA_20434984_ChIP-Seq_ESCs_Mouse2.16729069
28XRN2_22483619_ChIP-Seq_HELA_Human2.15713449
29PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.11995433
30E2F1_18555785_ChIP-Seq_MESCs_Mouse2.02009491
31E2F4_17652178_ChIP-ChIP_JURKAT_Human1.98593095
32SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.89079134
33SRF_21415370_ChIP-Seq_HL-1_Mouse1.87949635
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.87079024
35HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.83193203
36HOXB4_20404135_ChIP-ChIP_EML_Mouse1.79745747
37CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.73754790
38MYCN_18555785_ChIP-Seq_MESCs_Mouse1.73616221
39TTF2_22483619_ChIP-Seq_HELA_Human1.72025262
40FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.71941786
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.70068113
42FOXM1_23109430_ChIP-Seq_U2OS_Human1.68658025
43FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.67524161
44ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.64747030
45YY1_21170310_ChIP-Seq_MESCs_Mouse1.63982076
46CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.62851565
47ZFX_18555785_ChIP-Seq_MESCs_Mouse1.62593205
48TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.62165833
49ELK1_19687146_ChIP-ChIP_HELA_Human1.59706098
50TFEB_21752829_ChIP-Seq_HELA_Human1.57427243
51KDM5A_27292631_Chip-Seq_BREAST_Human1.56696782
52DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.52931671
53SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.48036730
54SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.43019103
55CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.40304704
56ERG_20887958_ChIP-Seq_HPC-7_Mouse1.38725414
57CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.36835330
58BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.34582435
59NANOG_18555785_ChIP-Seq_MESCs_Mouse1.34018587
60YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32653722
61CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.26109564
62SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.26107337
63CIITA_25753668_ChIP-Seq_RAJI_Human1.25568178
64PADI4_21655091_ChIP-ChIP_MCF-7_Human1.25536777
65MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.24345665
66NOTCH1_21737748_ChIP-Seq_TLL_Human1.23428781
67CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.22812669
68ZNF263_19887448_ChIP-Seq_K562_Human1.19618367
69E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17504341
70KLF4_18555785_ChIP-Seq_MESCs_Mouse1.11728081
71GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.11134426
72HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.08252935
73E2F1_21310950_ChIP-Seq_MCF-7_Human1.07295002
74PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.06857138
75ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.05492754
76TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04790886
77CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.02699485
78STAT3_1855785_ChIP-Seq_MESCs_Mouse1.01596544
79CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.99318911
80SPI1_23547873_ChIP-Seq_NB4_Human0.99114235
81HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.99079269
82TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97456989
83TBX5_21415370_ChIP-Seq_HL-1_Mouse0.96084966
84PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.94811613
85SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.92364009
86AR_21909140_ChIP-Seq_LNCAP_Human0.90226547
87STAT4_19710469_ChIP-ChIP_TH1__Mouse0.88098234
88ELK1_22589737_ChIP-Seq_MCF10A_Human0.87938500
89FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87877416
90CTCF_18555785_ChIP-Seq_MESCs_Mouse0.86673448
91CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.86434138
92DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.86146266
93IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.86092165
94MAF_26560356_Chip-Seq_TH2_Human0.83375621
95CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.83000487
96VDR_21846776_ChIP-Seq_THP-1_Human0.82814216
97MYC_22102868_ChIP-Seq_BL_Human0.81247385
98POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.81222542
99TET1_21451524_ChIP-Seq_MESCs_Mouse0.80468615
100TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.80459716

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.42091599
2MP0008058_abnormal_DNA_repair4.01047561
3MP0003111_abnormal_nucleus_morphology3.60766388
4MP0004957_abnormal_blastocyst_morpholog3.37542154
5MP0003806_abnormal_nucleotide_metabolis3.32826169
6MP0003077_abnormal_cell_cycle2.98730687
7MP0010094_abnormal_chromosome_stability2.96980263
8MP0003786_premature_aging2.84603099
9MP0003718_maternal_effect2.76767381
10MP0008260_abnormal_autophagy2.67827902
11MP0003186_abnormal_redox_activity2.66096054
12MP0009333_abnormal_splenocyte_physiolog2.54426069
13MP0006036_abnormal_mitochondrial_physio2.54124709
14MP0008932_abnormal_embryonic_tissue2.39353239
15MP0006035_abnormal_mitochondrial_morpho2.39224713
16MP0008007_abnormal_cellular_replicative2.38184129
17MP0005058_abnormal_lysosome_morphology2.19384455
18MP0008877_abnormal_DNA_methylation2.14904369
19MP0002210_abnormal_sex_determination1.85915801
20MP0001730_embryonic_growth_arrest1.83128981
21MP0009697_abnormal_copulation1.72658342
22MP0001853_heart_inflammation1.72279092
23MP0000358_abnormal_cell_content/1.70223000
24MP0008995_early_reproductive_senescence1.69279143
25MP0001929_abnormal_gametogenesis1.65923897
26MP0008789_abnormal_olfactory_epithelium1.62559846
27MP0000372_irregular_coat_pigmentation1.57065800
28MP0000313_abnormal_cell_death1.51630624
29MP0000350_abnormal_cell_proliferation1.50057221
30MP0001727_abnormal_embryo_implantation1.47458391
31MP0001764_abnormal_homeostasis1.44747578
32MP0002148_abnormal_hypersensitivity_rea1.43215116
33MP0002396_abnormal_hematopoietic_system1.41923878
34MP0005394_taste/olfaction_phenotype1.39399069
35MP0005499_abnormal_olfactory_system1.39399069
36MP0002877_abnormal_melanocyte_morpholog1.36225541
37MP0001145_abnormal_male_reproductive1.36018014
38MP0002132_abnormal_respiratory_system1.35451956
39MP0000653_abnormal_sex_gland1.31462030
40MP0005671_abnormal_response_to1.26115002
41MP0000678_abnormal_parathyroid_gland1.23772402
42MP0003763_abnormal_thymus_physiology1.22518500
43MP0002019_abnormal_tumor_incidence1.20787468
44MP0000703_abnormal_thymus_morphology1.20168664
45MP0005451_abnormal_body_composition1.18099106
46MP0010307_abnormal_tumor_latency1.16102547
47MP0002080_prenatal_lethality1.15543261
48MP0002160_abnormal_reproductive_system1.12097444
49MP0008004_abnormal_stomach_pH1.12012772
50MP0005410_abnormal_fertilization1.09345758
51MP0009840_abnormal_foam_cell1.09150234
52MP0002277_abnormal_respiratory_mucosa1.08474119
53MP0002722_abnormal_immune_system1.08360919
54MP0005395_other_phenotype1.08319287
55MP0000858_altered_metastatic_potential1.08049346
56MP0002398_abnormal_bone_marrow1.07982316
57MP0005380_embryogenesis_phenotype1.06972927
58MP0001672_abnormal_embryogenesis/_devel1.06972927
59MP0001697_abnormal_embryo_size1.05424233
60MP0001661_extended_life_span1.05418428
61MP0005075_abnormal_melanosome_morpholog1.04861712
62MP0000490_abnormal_crypts_of1.02487397
63MP0005501_abnormal_skin_physiology1.02280848
64MP0000689_abnormal_spleen_morphology1.01346336
65MP0009785_altered_susceptibility_to1.00912100
66MP0003699_abnormal_female_reproductive0.99801711
67MP0002796_impaired_skin_barrier0.97342455
68MP0002429_abnormal_blood_cell0.94798744
69MP0003698_abnormal_male_reproductive0.92539579
70MP0002161_abnormal_fertility/fecundity0.91857967
71MP0000015_abnormal_ear_pigmentation0.91818391
72MP0001119_abnormal_female_reproductive0.90023034
73MP0005319_abnormal_enzyme/_coenzyme0.89569138
74MP0005384_cellular_phenotype0.89225617
75MP0005000_abnormal_immune_tolerance0.89111255
76MP0001188_hyperpigmentation0.87996633
77MP0000343_altered_response_to0.85666107
78MP0005464_abnormal_platelet_physiology0.85316551
79MP0002420_abnormal_adaptive_immunity0.85303635
80MP0001881_abnormal_mammary_gland0.84889133
81MP0008057_abnormal_DNA_replication0.83190051
82MP0000716_abnormal_immune_system0.82996533
83MP0001819_abnormal_immune_cell0.82646546
84MP0002736_abnormal_nociception_after0.82465468
85MP0002723_abnormal_immune_serum0.81931983
86MP0003984_embryonic_growth_retardation0.81389977
87MP0003941_abnormal_skin_development0.80067706
88MP0005670_abnormal_white_adipose0.77568484
89MP0001529_abnormal_vocalization0.77185234
90MP0004381_abnormal_hair_follicle0.77148484
91MP0008873_increased_physiological_sensi0.76683765
92MP0001873_stomach_inflammation0.75994856
93MP0002452_abnormal_antigen_presenting0.75570252
94MP0006082_CNS_inflammation0.75450273
95MP0002088_abnormal_embryonic_growth/wei0.75012372
96MP0005408_hypopigmentation0.73669274
97MP0001243_abnormal_dermal_layer0.71876024
98MP0004233_abnormal_muscle_weight0.71734981
99MP0005621_abnormal_cell_physiology0.70820575
100MP0010030_abnormal_orbit_morphology0.70441981

Predicted human phenotypes

RankGene SetZ-score
1Cholecystitis (HP:0001082)4.22864684
2Abnormal gallbladder physiology (HP:0012438)4.22864684
3Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.12267813
4Decreased activity of mitochondrial respiratory chain (HP:0008972)4.12267813
5Acute necrotizing encephalopathy (HP:0006965)3.81512616
6Abnormal mitochondria in muscle tissue (HP:0008316)3.81411343
7Microvesicular hepatic steatosis (HP:0001414)3.66291668
8Increased serum pyruvate (HP:0003542)3.33464545
9Abnormal umbilical cord blood vessels (HP:0011403)3.29589915
10Single umbilical artery (HP:0001195)3.29589915
11Abnormality of the fetal cardiovascular system (HP:0010948)3.29589915
12Acute encephalopathy (HP:0006846)3.27513503
13Mitochondrial inheritance (HP:0001427)3.23665184
14Premature ovarian failure (HP:0008209)3.23028998
15Abnormality of glycolysis (HP:0004366)3.18076296
16Type I transferrin isoform profile (HP:0003642)3.14786388
17Increased CSF lactate (HP:0002490)3.13896600
18Cerebral hypomyelination (HP:0006808)3.13335773
19Rough bone trabeculation (HP:0100670)3.06407333
20Abnormality of alanine metabolism (HP:0010916)3.00771965
21Hyperalaninemia (HP:0003348)3.00771965
22Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.00771965
23Microretrognathia (HP:0000308)2.92994207
24Progressive macrocephaly (HP:0004481)2.92847050
25Hepatocellular necrosis (HP:0001404)2.92758852
26Abnormal protein glycosylation (HP:0012346)2.92572965
27Abnormal glycosylation (HP:0012345)2.92572965
28Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.92572965
29Abnormal protein N-linked glycosylation (HP:0012347)2.92572965
30Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.92153048
31Increased serum lactate (HP:0002151)2.87368118
32Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.86890198
33Lactic acidosis (HP:0003128)2.82408735
34Hepatic necrosis (HP:0002605)2.81007189
35Degeneration of anterior horn cells (HP:0002398)2.79209361
36Abnormality of the anterior horn cell (HP:0006802)2.79209361
37Generalized aminoaciduria (HP:0002909)2.75282695
38Abnormality of the umbilical cord (HP:0010881)2.69983758
39Exercise intolerance (HP:0003546)2.68890971
40Nausea (HP:0002018)2.68278529
41Cerebral edema (HP:0002181)2.66211765
42Aplastic anemia (HP:0001915)2.65456044
43Reduced antithrombin III activity (HP:0001976)2.64239431
44Aplasia/Hypoplasia of the sacrum (HP:0008517)2.62393994
45Increased intramyocellular lipid droplets (HP:0012240)2.59872212
46Abnormality of lateral ventricle (HP:0030047)2.58230673
47Renal Fanconi syndrome (HP:0001994)2.57313610
48Hypokinesia (HP:0002375)2.57157787
49Secondary amenorrhea (HP:0000869)2.54233426
50Abnormal trabecular bone morphology (HP:0100671)2.49434471
51Oral leukoplakia (HP:0002745)2.45445431
523-Methylglutaconic aciduria (HP:0003535)2.45158750
53Reticulocytopenia (HP:0001896)2.43194183
54Carpal bone hypoplasia (HP:0001498)2.41254805
55Multiple enchondromatosis (HP:0005701)2.33399286
56Progressive muscle weakness (HP:0003323)2.32209705
57Ragged-red muscle fibers (HP:0003200)2.30684740
58Increased muscle lipid content (HP:0009058)2.27125386
59Chromosomal breakage induced by crosslinking agents (HP:0003221)2.23288031
60Horseshoe kidney (HP:0000085)2.22118689
61Increased hepatocellular lipid droplets (HP:0006565)2.18391812
62Fatigue (HP:0012378)2.17516916
63Sparse eyelashes (HP:0000653)2.14308935
64Respiratory failure (HP:0002878)2.11577947
65Chromsome breakage (HP:0040012)2.07605614
66CNS hypomyelination (HP:0003429)2.05109653
67Respiratory difficulties (HP:0002880)2.04133166
68Pancytopenia (HP:0001876)2.03746224
69Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.00927759
70Abnormalities of placenta or umbilical cord (HP:0001194)2.00142655
71Lipid accumulation in hepatocytes (HP:0006561)1.99370930
72Abnormality of the preputium (HP:0100587)1.97880795
73Delusions (HP:0000746)1.94175967
74Cortical visual impairment (HP:0100704)1.93671076
75Progressive external ophthalmoplegia (HP:0000590)1.93228841
76Aplasia/hypoplasia of the uterus (HP:0008684)1.90313038
77Postnatal microcephaly (HP:0005484)1.90054541
78Cholelithiasis (HP:0001081)1.88709395
79Congenital ichthyosiform erythroderma (HP:0007431)1.88209978
80Testicular atrophy (HP:0000029)1.87708462
81Abnormal number of erythroid precursors (HP:0012131)1.87410235
82Increased IgM level (HP:0003496)1.85688101
83X-linked dominant inheritance (HP:0001423)1.84705576
84Hepatosplenomegaly (HP:0001433)1.84027336
85Unsteady gait (HP:0002317)1.83364924
86Lethargy (HP:0001254)1.82292410
87Cleft eyelid (HP:0000625)1.80159573
88Trismus (HP:0000211)1.79675567
89J-shaped sella turcica (HP:0002680)1.78924744
90Bone marrow hypocellularity (HP:0005528)1.78488549
91Abnormal lung lobation (HP:0002101)1.78110540
92Hypergonadotropic hypogonadism (HP:0000815)1.76834139
93Abnormality of aromatic amino acid family metabolism (HP:0004338)1.76749240
94Short tibia (HP:0005736)1.76346323
95Abnormality of methionine metabolism (HP:0010901)1.74101383
96Abnormal gallbladder morphology (HP:0012437)1.74065613
97Ureteral duplication (HP:0000073)1.73611375
98Abnormality of the labia minora (HP:0012880)1.72449711
99Death in infancy (HP:0001522)1.72429818
100Emotional lability (HP:0000712)1.72310432

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.76255550
2NME24.67683249
3VRK23.54281050
4TESK23.42470886
5STK163.40952418
6PBK3.11382213
7SRPK12.96725835
8TRIM282.79082787
9PDK22.63947996
10ARAF2.40343131
11MST42.38429578
12EIF2AK12.35344897
13EIF2AK32.30313498
14IRAK32.24478777
15BCKDK2.19067733
16TTK1.84179542
17MAP3K31.83658276
18TESK11.73609075
19KDR1.58369183
20NEK11.51378008
21NME11.51039960
22SIK31.50762351
23TXK1.50015708
24PIM21.49245291
25VRK11.34538269
26MARK31.26499987
27TAOK21.24218975
28BRAF1.14529183
29NUAK11.14426135
30BRSK11.10789261
31ZAK1.09775625
32CCNB11.08888938
33PLK11.08547838
34MAP2K31.08116132
35CDK191.07385837
36PAK41.07193973
37MAP4K21.06302477
38PLK31.01460033
39RAF10.99431281
40SMG10.98658308
41TBK10.93118831
42PRKCI0.92576667
43PAK10.91087636
44AURKA0.89630505
45CLK10.86588046
46CDC70.84545244
47IRAK20.83527933
48MAP3K50.79641288
49CDK90.79574426
50LRRK20.79344546
51ATR0.76695333
52AURKB0.75197240
53MAP4K10.74576537
54ILK0.73386334
55MAP3K80.72676251
56CDK70.72035746
57TSSK60.66811301
58CSNK1G30.66621453
59STK100.64328255
60STK40.63711358
61CHEK10.61543042
62DAPK10.60418426
63PRPF4B0.59804657
64RPS6KB20.58509548
65EPHA20.57897026
66PLK40.57672635
67LIMK10.57309167
68CSNK2A10.56596796
69IKBKB0.56017138
70BRSK20.54097275
71RPS6KA50.52511882
72BCR0.49664187
73ABL20.49647353
74CSNK2A20.48551044
75CHEK20.46953313
76NEK60.44860559
77DYRK30.44706266
78WEE10.41170142
79IRAK40.41000296
80BMX0.39656990
81EIF2AK20.38885909
82AKT20.38822624
83FGR0.38141980
84PRKCQ0.35856270
85JAK30.35572332
86CSNK1A1L0.35390060
87RPS6KA40.35373162
88MKNK10.34642768
89CDK80.33704649
90MAP3K90.33653039
91CSNK1G10.32483021
92MAPKAPK20.28276509
93MYLK0.26865960
94MAP2K70.26213969
95CDK20.25874818
96MST1R0.25578234
97ATM0.25314633
98ALK0.24985458
99MAP3K120.24268338
100MOS0.23419351

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.30726036
2DNA replication_Homo sapiens_hsa030303.17620501
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.10618563
4RNA polymerase_Homo sapiens_hsa030203.08818568
5Mismatch repair_Homo sapiens_hsa034302.85777876
6Base excision repair_Homo sapiens_hsa034102.78901285
7Ribosome_Homo sapiens_hsa030102.64884913
8Oxidative phosphorylation_Homo sapiens_hsa001902.58968393
9Parkinsons disease_Homo sapiens_hsa050122.48425554
10Spliceosome_Homo sapiens_hsa030402.38055768
11RNA transport_Homo sapiens_hsa030132.24264699
12Pyrimidine metabolism_Homo sapiens_hsa002402.09553296
13Sulfur relay system_Homo sapiens_hsa041222.01598905
14Basal transcription factors_Homo sapiens_hsa030221.97317194
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.96547255
16Huntingtons disease_Homo sapiens_hsa050161.78910543
17Protein export_Homo sapiens_hsa030601.77998310
18Nucleotide excision repair_Homo sapiens_hsa034201.76062623
19Homologous recombination_Homo sapiens_hsa034401.75858425
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.71483349
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.70607831
22Fatty acid elongation_Homo sapiens_hsa000621.62264987
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.60624486
24Sulfur metabolism_Homo sapiens_hsa009201.57353853
25Cysteine and methionine metabolism_Homo sapiens_hsa002701.49413466
26Cell cycle_Homo sapiens_hsa041101.49226507
27RNA degradation_Homo sapiens_hsa030181.38948860
28mRNA surveillance pathway_Homo sapiens_hsa030151.37098529
29Non-homologous end-joining_Homo sapiens_hsa034501.36400238
30Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.36293382
31Glutathione metabolism_Homo sapiens_hsa004801.21686213
32Alzheimers disease_Homo sapiens_hsa050101.21556886
33Collecting duct acid secretion_Homo sapiens_hsa049661.20984349
34Folate biosynthesis_Homo sapiens_hsa007901.19385221
35One carbon pool by folate_Homo sapiens_hsa006701.18239934
36Biosynthesis of amino acids_Homo sapiens_hsa012301.17543821
37Purine metabolism_Homo sapiens_hsa002301.16084449
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.14048767
39Fanconi anemia pathway_Homo sapiens_hsa034601.11737122
40Epstein-Barr virus infection_Homo sapiens_hsa051691.11009207
41Vibrio cholerae infection_Homo sapiens_hsa051101.09165307
42Pentose phosphate pathway_Homo sapiens_hsa000301.06611541
43Carbon metabolism_Homo sapiens_hsa012001.06309634
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.03226700
45p53 signaling pathway_Homo sapiens_hsa041151.02080398
46Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.99255468
47Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.98941792
48Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.96713202
49Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.93026890
50N-Glycan biosynthesis_Homo sapiens_hsa005100.92416958
51Pyruvate metabolism_Homo sapiens_hsa006200.91964226
52Steroid biosynthesis_Homo sapiens_hsa001000.91490666
53Galactose metabolism_Homo sapiens_hsa000520.88600947
54Regulation of autophagy_Homo sapiens_hsa041400.87180951
55Primary immunodeficiency_Homo sapiens_hsa053400.86619177
56Rheumatoid arthritis_Homo sapiens_hsa053230.83972571
57SNARE interactions in vesicular transport_Homo sapiens_hsa041300.83643238
58Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.82812657
59Oocyte meiosis_Homo sapiens_hsa041140.79069713
60Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.78574983
61Shigellosis_Homo sapiens_hsa051310.72725485
62Selenocompound metabolism_Homo sapiens_hsa004500.70653952
63Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.69621152
64Fructose and mannose metabolism_Homo sapiens_hsa000510.68452385
65Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.63643618
66Metabolic pathways_Homo sapiens_hsa011000.63453349
67Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.58623376
68Herpes simplex infection_Homo sapiens_hsa051680.58298886
69Legionellosis_Homo sapiens_hsa051340.58127477
70Other glycan degradation_Homo sapiens_hsa005110.58070448
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56175577
72Apoptosis_Homo sapiens_hsa042100.54505013
73Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54399929
74Salmonella infection_Homo sapiens_hsa051320.53701320
75Propanoate metabolism_Homo sapiens_hsa006400.48696444
76RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.48215407
77Lysosome_Homo sapiens_hsa041420.45050889
78Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.43813464
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.41877238
80Antigen processing and presentation_Homo sapiens_hsa046120.40727078
81Measles_Homo sapiens_hsa051620.38209851
82Viral carcinogenesis_Homo sapiens_hsa052030.37049004
83Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.36033766
84NF-kappa B signaling pathway_Homo sapiens_hsa040640.35878944
85Peroxisome_Homo sapiens_hsa041460.35559619
86HTLV-I infection_Homo sapiens_hsa051660.35332222
87Glycosaminoglycan degradation_Homo sapiens_hsa005310.32245729
88Autoimmune thyroid disease_Homo sapiens_hsa053200.29184798
89Allograft rejection_Homo sapiens_hsa053300.27650478
90Arginine and proline metabolism_Homo sapiens_hsa003300.27606400
91Toll-like receptor signaling pathway_Homo sapiens_hsa046200.26231921
92Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.22225208
93Cyanoamino acid metabolism_Homo sapiens_hsa004600.22113443
94Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.21363559
95Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.17008871
96Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.16674804
97Influenza A_Homo sapiens_hsa051640.16370392
98Graft-versus-host disease_Homo sapiens_hsa053320.13837119
99Thyroid cancer_Homo sapiens_hsa052160.13722297
100Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.12091227

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