ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	male meiosis (GO:0007140)	9.21317011
2	synapsis (GO:0007129)	6.64479241
3	positive regulation of catecholamine secretion (GO:0033605)	6.63555156
4	binding of sperm to zona pellucida (GO:0007339)	6.55342324
5	chromosome organization involved in meiosis (GO:0070192)	5.89204228
6	meiotic nuclear division (GO:0007126)	5.86106664
7	piRNA metabolic process (GO:0034587)	5.83214095
8	synaptonemal complex assembly (GO:0007130)	5.58905905
9	male meiosis I (GO:0007141)	5.57474949
10	regulation of phosphoprotein phosphatase activity (GO:0043666)	5.57440597
11	spermatid development (GO:0007286)	5.50340523
12	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	5.49020008
13	acrosome reaction (GO:0007340)	5.42429721
14	meiosis I (GO:0007127)	5.12908156
15	synaptonemal complex organization (GO:0070193)	5.10290627
16	multicellular organism reproduction (GO:0032504)	5.02756961
17	sperm-egg recognition (GO:0035036)	4.97935131
18	DNA synthesis involved in DNA repair (GO:0000731)	4.79547122
19	DNA methylation involved in gamete generation (GO:0043046)	4.55868088
20	negative regulation of macroautophagy (GO:0016242)	4.44239264
21	DNA replication initiation (GO:0006270)	4.31642577
22	regulation of oxidative phosphorylation (GO:0002082)	4.30957098
23	cell-cell recognition (GO:0009988)	4.28406749
24	sperm motility (GO:0030317)	4.28025662
25	diterpenoid biosynthetic process (GO:0016102)	4.22427855
26	histone H3-K9 demethylation (GO:0033169)	4.03291818
27	regulation of oxidative stress-induced neuron death (GO:1903203)	4.02568879
28	histone exchange (GO:0043486)	3.99178882
29	ribosome assembly (GO:0042255)	3.94979333
30	meiotic cell cycle process (GO:1903046)	3.81749869
31	regulation of interleukin-5 production (GO:0032674)	3.81056578
32	motile cilium assembly (GO:0044458)	3.79628118
33	potassium ion export (GO:0071435)	3.77520105
34	response to acidic pH (GO:0010447)	3.74373747
35	TOR signaling (GO:0031929)	3.74111501
36	regulation of meiosis I (GO:0060631)	3.74025558
37	germ cell development (GO:0007281)	3.68631847
38	notochord development (GO:0030903)	3.66997318
39	polyamine biosynthetic process (GO:0006596)	3.62885300
40	proteasome assembly (GO:0043248)	3.62769423
41	tongue development (GO:0043586)	3.60713240
42	rRNA methylation (GO:0031167)	3.59924418
43	activation of protein kinase B activity (GO:0032148)	3.59699001
44	rRNA modification (GO:0000154)	3.58480825
45	single fertilization (GO:0007338)	3.57243392
46	terpenoid biosynthetic process (GO:0016114)	3.55179208
47	N-terminal protein amino acid acetylation (GO:0006474)	3.49413768
48	regulation of autophagic vacuole assembly (GO:2000785)	3.48573764
49	regulation of cellular respiration (GO:0043457)	3.44718385
50	fertilization (GO:0009566)	3.31245296
51	regulation of hydrogen peroxide-induced cell death (GO:1903205)	3.28720842
52	de novo posttranslational protein folding (GO:0051084)	3.27934562
53	de novo protein folding (GO:0006458)	3.26034243
54	reproduction (GO:0000003)	3.20966138
55	relaxation of smooth muscle (GO:0044557)	3.20270459
56	sister chromatid cohesion (GO:0007062)	3.18888881
57	negative regulation of hydrogen peroxide-induced cell death (GO:1903206)	3.18251568
58	organic cation transport (GO:0015695)	3.12482619
59	histone H3-K36 demethylation (GO:0070544)	3.12299871
60	mRNA cleavage (GO:0006379)	3.12165937
61	negative regulation of cardiac muscle cell apoptotic process (GO:0010667)	3.12014592
62	oocyte development (GO:0048599)	3.06291520
63	oogenesis (GO:0048477)	3.03357374
64	negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)	3.01590275
65	cellular process involved in reproduction in multicellular organism (GO:0022412)	2.98669219
66	poly(A)+ mRNA export from nucleus (GO:0016973)	2.98301287
67	female gamete generation (GO:0007292)	2.97661690
68	morphogenesis of embryonic epithelium (GO:0016331)	2.97560710
69	fusion of sperm to egg plasma membrane (GO:0007342)	2.93915067
70	centriole assembly (GO:0098534)	2.92073365
71	DNA double-strand break processing (GO:0000729)	2.89123630
72	regulation of cardioblast differentiation (GO:0051890)	2.87835340
73	male sex determination (GO:0030238)	2.86879920
74	regulation of vacuole organization (GO:0044088)	2.86770070
75	negative regulation of response to reactive oxygen species (GO:1901032)	2.83633370
76	epithelial cilium movement (GO:0003351)	2.81862942
77	Leydig cell differentiation (GO:0033327)	2.78760411
78	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	2.78554291
79	ectoderm development (GO:0007398)	2.74398353
80	regulation of keratinocyte proliferation (GO:0010837)	2.73243502
81	keratinocyte development (GO:0003334)	2.73235983
82	genitalia morphogenesis (GO:0035112)	2.71208603
83	DNA replication-dependent nucleosome assembly (GO:0006335)	2.66173816
84	DNA replication-dependent nucleosome organization (GO:0034723)	2.66173816
85	protein-DNA complex disassembly (GO:0032986)	2.61252826
86	nucleosome disassembly (GO:0006337)	2.61252826
87	telomere maintenance (GO:0000723)	2.61195499
88	regulation of acrosome reaction (GO:0060046)	2.56960928
89	protein polymerization (GO:0051258)	2.56781816
90	chromosome organization (GO:0051276)	2.56511341
91	telomere organization (GO:0032200)	2.56407474
92	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	2.55557698
93	glycogen metabolic process (GO:0005977)	2.54676773
94	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.51234023
95	hippo signaling (GO:0035329)	2.51025014
96	glucan metabolic process (GO:0044042)	2.49817400
97	cellular glucan metabolic process (GO:0006073)	2.49817400
98	cellular response to pH (GO:0071467)	2.46512394
99	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	14.5074166
100	regulation of retinoic acid receptor signaling pathway (GO:0048385)	12.2590505

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	8.24829757
2	BP1_19119308_ChIP-ChIP_Hs578T_Human	5.02524772
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.38546000
4	IGF1R_20145208_ChIP-Seq_DFB_Human	4.32707093
5	E2F7_22180533_ChIP-Seq_HELA_Human	3.74490607
6	AR_21909140_ChIP-Seq_LNCAP_Human	3.39486789
7	ESR1_20079471_ChIP-ChIP_T-47D_Human	3.09057976
8	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.72316292
9	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.60462597
10	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.57946445
11	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	2.47355904
12	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	2.29661777
13	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.27708254
14	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.26303718
15	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.16086317
16	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.14650198
17	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.03950850
18	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.01711207
19	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.86312828
20	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.82700476
21	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.77425760
22	ZNF263_19887448_ChIP-Seq_K562_Human	1.66963634
23	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.59832773
24	RAC3_21632823_ChIP-Seq_H3396_Human	1.59585458
25	GABP_19822575_ChIP-Seq_HepG2_Human	1.58948992
26	ELF5_23300383_ChIP-Seq_T47D_Human	1.56243617
27	NANOG_20526341_ChIP-Seq_ESCs_Human	1.50196253
28	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.48968796
29	DCP1A_22483619_ChIP-Seq_HELA_Human	1.48326322
30	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.47833390
31	SMC4_20622854_ChIP-Seq_HELA_Human	1.46869493
32	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.44920571
33	ZNF274_21170338_ChIP-Seq_K562_Hela	1.41522124
34	RBPJ_21746931_ChIP-Seq_IB4_Human	1.40916163
35	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.40191915
36	ERA_21632823_ChIP-Seq_H3396_Human	1.36150038
37	MYC_19829295_ChIP-Seq_ESCs_Human	1.33790241
38	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.31537916
39	ETV1_20927104_ChIP-Seq_GIST48_Human	1.29981840
40	HOXB7_26014856_ChIP-Seq_BT474_Human	1.29833265
41	AHR_22903824_ChIP-Seq_MCF-7_Human	1.29264400
42	PKCTHETA_26484144_Chip-Seq_BREAST_Human	1.25661425
43	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.24613985
44	OCT4_20526341_ChIP-Seq_ESCs_Human	1.24428979
45	PHF8_20622853_ChIP-Seq_HELA_Human	1.23347251
46	TBL1_22424771_ChIP-Seq_293T_Human	1.22763542
47	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.20809938
48	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.20809938
49	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.20809938
50	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.20659603
51	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.19657130
52	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.16817854
53	SMAD1_18555785_ChIP-Seq_MESCs_Mouse	1.14267532
54	AR_21572438_ChIP-Seq_LNCaP_Human	1.13071512
55	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.12667137
56	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.11844280
57	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.09937251
58	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.09787595
59	CTCF_20526341_ChIP-Seq_ESCs_Human	1.09221223
60	KDM5A_27292631_Chip-Seq_BREAST_Human	1.09037157
61	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.09027973
62	E2F1_20622854_ChIP-Seq_HELA_Human	1.08496813
63	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	1.07602860
64	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.07315196
65	PHF8_20622854_ChIP-Seq_HELA_Human	1.07259194
66	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.06002460
67	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.04725626
68	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.04551086
69	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.04174671
70	NFYB_21822215_ChIP-Seq_K562_Human	1.03651141
71	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.03596284
72	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.02600961
73	IRF1_19129219_ChIP-ChIP_H3396_Human	1.00965294
74	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.00075778
75	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.98807743
76	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.98668522
77	HNFA_21074721_ChIP-Seq_CACO-2_Human	0.98298520
78	CTCF_27219007_Chip-Seq_Bcells_Human	0.98090687
79	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.97573951
80	P300_27268052_Chip-Seq_Bcells_Human	0.95080982
81	ATF3_27146783_Chip-Seq_COLON_Human	0.94974777
82	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.93691398
83	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	0.93303972
84	TFAP2A_17053090_ChIP-ChIP_MCF-7_Human	0.92572039
85	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.92300690
86	BCOR_27268052_Chip-Seq_Bcells_Human	0.90941985
87	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	0.89168558
88	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.89019276
89	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.86967957
90	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.86558375
91	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	0.85674795
92	VDR_23849224_ChIP-Seq_CD4+_Human	0.84679708
93	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.84367699
94	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	0.84292319
95	P68_20966046_ChIP-Seq_HELA_Human	0.84277935
96	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.83386688
97	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.82014594
98	EST1_17652178_ChIP-ChIP_JURKAT_Human	0.82000466
99	CBX2_22325352_ChIP-Seq_293T-Rex_Human	0.80554834
100	PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	0.80107106

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	5.35777036
2	MP0003315_abnormal_perineum_morphology	4.33659938
3	MP0003693_abnormal_embryo_hatching	3.61095185
4	MP0008004_abnormal_stomach_pH	3.46641946
5	MP0002160_abnormal_reproductive_system	3.36284474
6	MP0008877_abnormal_DNA_methylation	2.95876374
7	MP0001929_abnormal_gametogenesis	2.94610139
8	MP0003718_maternal_effect	2.88130541
9	MP0002210_abnormal_sex_determination	2.71963577
10	MP0003698_abnormal_male_reproductive	2.65909392
11	MP0010234_abnormal_vibrissa_follicle	2.64269325
12	MP0002163_abnormal_gland_morphology	2.41679606
13	MP0002796_impaired_skin_barrier	2.16999366
14	MP0004381_abnormal_hair_follicle	2.15609312
15	MP0005360_urolithiasis	2.13557355
16	MP0002132_abnormal_respiratory_system	2.13305525
17	MP0000569_abnormal_digit_pigmentation	2.11934113
18	MP0003806_abnormal_nucleotide_metabolis	2.06185629
19	MP0008058_abnormal_DNA_repair	2.06051069
20	MP0000537_abnormal_urethra_morphology	1.99756540
21	MP0001145_abnormal_male_reproductive	1.96847100
22	MP0000653_abnormal_sex_gland	1.95500563
23	MP0003077_abnormal_cell_cycle	1.95459036
24	MP0005379_endocrine/exocrine_gland_phen	1.95378303
25	MP0001849_ear_inflammation	1.85015943
26	MP0010094_abnormal_chromosome_stability	1.84652941
27	MP0004957_abnormal_blastocyst_morpholog	1.84063157
28	MP0001348_abnormal_lacrimal_gland	1.83717585
29	MP0001188_hyperpigmentation	1.64649357
30	MP0002161_abnormal_fertility/fecundity	1.64457628
31	MP0004264_abnormal_extraembryonic_tissu	1.62900345
32	MP0005499_abnormal_olfactory_system	1.62873494
33	MP0005394_taste/olfaction_phenotype	1.62873494
34	MP0010678_abnormal_skin_adnexa	1.59677952
35	MP0003136_yellow_coat_color	1.59156686
36	MP0003936_abnormal_reproductive_system	1.49957886
37	MP0005389_reproductive_system_phenotype	1.49724306
38	MP0008995_early_reproductive_senescence	1.44359434
39	MP0005647_abnormal_sex_gland	1.41682739
40	MP0010368_abnormal_lymphatic_system	1.40010095
41	MP0001664_abnormal_digestion	1.39060112
42	MP0005058_abnormal_lysosome_morphology	1.37048611
43	MP0002233_abnormal_nose_morphology	1.33111133
44	MP0005501_abnormal_skin_physiology	1.32047630
45	MP0000762_abnormal_tongue_morphology	1.29448281
46	MP0002138_abnormal_hepatobiliary_system	1.28307814
47	MP0004272_abnormal_basement_membrane	1.28272874
48	MP0002254_reproductive_system_inflammat	1.27685870
49	MP0003111_abnormal_nucleus_morphology	1.27574400
50	MP0009697_abnormal_copulation	1.26259869
51	MP0000678_abnormal_parathyroid_gland	1.26187276
52	MP0005395_other_phenotype	1.26108198
53	MP0003045_fibrosis	1.25893771
54	MP0001984_abnormal_olfaction	1.18894514
55	MP0006036_abnormal_mitochondrial_physio	1.18877088
56	MP0001730_embryonic_growth_arrest	1.17754991
57	MP0010030_abnormal_orbit_morphology	1.16882049
58	MP0005187_abnormal_penis_morphology	1.11220133
59	MP0000627_abnormal_mammary_gland	1.10126752
60	MP0005171_absent_coat_pigmentation	1.09335896
61	MP0003699_abnormal_female_reproductive	1.07600039
62	MP0000462_abnormal_digestive_system	1.05519432
63	MP0002089_abnormal_postnatal_growth/wei	1.04966505
64	MP0006035_abnormal_mitochondrial_morpho	1.01026612
65	MP0000470_abnormal_stomach_morphology	0.96990822
66	MP0008789_abnormal_olfactory_epithelium	0.96852643
67	MP0003941_abnormal_skin_development	0.95197975
68	MP0003385_abnormal_body_wall	0.94439923
69	MP0000647_abnormal_sebaceous_gland	0.94195654
70	MP0005174_abnormal_tail_pigmentation	0.92867517
71	MP0008932_abnormal_embryonic_tissue	0.91515207
72	MP0001672_abnormal_embryogenesis/_devel	0.91327130
73	MP0005380_embryogenesis_phenotype	0.91327130
74	MP0005646_abnormal_pituitary_gland	0.88151293
75	MP0002127_abnormal_cardiovascular_syste	0.87778220
76	MP0003786_premature_aging	0.87087778
77	MP0001119_abnormal_female_reproductive	0.86460883
78	MP0000477_abnormal_intestine_morphology	0.85691720
79	MP0000015_abnormal_ear_pigmentation	0.83542473
80	MP0003453_abnormal_keratinocyte_physiol	0.83382331
81	MP0005409_darkened_coat_color	0.81129248
82	MP0003646_muscle_fatigue	0.80563105
83	MP0001905_abnormal_dopamine_level	0.79990787
84	MP0006138_congestive_heart_failure	0.79436828
85	MP0005248_abnormal_Harderian_gland	0.78443814
86	MP0008260_abnormal_autophagy	0.78203542
87	MP0001697_abnormal_embryo_size	0.78076654
88	MP0000579_abnormal_nail_morphology	0.78056766
89	MP0010771_integument_phenotype	0.75374641
90	MP0000566_synostosis	0.72244541
91	MP0002080_prenatal_lethality	0.71250978
92	MP0000538_abnormal_urinary_bladder	0.70015848
93	MP0001216_abnormal_epidermal_layer	0.69658078
94	MP0005330_cardiomyopathy	0.69197971
95	MP0002086_abnormal_extraembryonic_tissu	0.69104930
96	MP0000490_abnormal_crypts_of	0.67167224
97	MP0001986_abnormal_taste_sensitivity	0.67109842
98	MP0000631_abnormal_neuroendocrine_gland	0.62429484
99	MP0002084_abnormal_developmental_patter	0.61725795
100	MP0003984_embryonic_growth_retardation	0.60867383

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hypoplasia of the uterus (HP:0000013)	6.58766508
2	Aplasia/hypoplasia of the uterus (HP:0008684)	5.48976884
3	Facial hemangioma (HP:0000329)	5.17243635
4	Thoracolumbar scoliosis (HP:0002944)	4.40697742
5	Resting tremor (HP:0002322)	4.21712594
6	Reduced antithrombin III activity (HP:0001976)	4.21611697
7	Lip pit (HP:0100267)	4.21064082
8	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	3.91567526
9	Absent epiphyses (HP:0010577)	3.91567526
10	Abnormal tarsal ossification (HP:0008369)	3.90993752
11	Pili torti (HP:0003777)	3.87785492
12	Hypoplastic ischia (HP:0003175)	3.74574496
13	Thoracic kyphosis (HP:0002942)	3.56280018
14	Abnormal sex determination (HP:0012244)	3.44867975
15	Sex reversal (HP:0012245)	3.44867975
16	Capillary hemangiomas (HP:0005306)	3.41941948
17	Abnormality of the columella (HP:0009929)	3.39993739
18	Abnormality of the ischium (HP:0003174)	3.24411062
19	Vitreoretinal degeneration (HP:0000655)	3.20278326
20	Flattened epiphyses (HP:0003071)	3.11226075
21	Abnormality of the lumbar spine (HP:0100712)	3.07454476
22	Epiphyseal dysplasia (HP:0002656)	3.06922796
23	Hypotrichosis (HP:0001006)	3.05883134
24	Gonadotropin excess (HP:0000837)	3.02357921
25	Hypoplastic pelvis (HP:0008839)	2.97478316
26	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.88501970
27	High anterior hairline (HP:0009890)	2.79346404
28	Germ cell neoplasia (HP:0100728)	2.78388464
29	Aplasia cutis congenita (HP:0001057)	2.77611001
30	Gonadal dysgenesis (HP:0000133)	2.75060094
31	Flat acetabular roof (HP:0003180)	2.74377421
32	Urinary urgency (HP:0000012)	2.60796704
33	Abnormality of cochlea (HP:0000375)	2.59445476
34	Infertility (HP:0000789)	2.57827387
35	Vertebral clefting (HP:0008428)	2.54676833
36	Abnormal foot bone ossification (HP:0010675)	2.54454353
37	Abnormality of the thoracic spine (HP:0100711)	2.53907152
38	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.53484755
39	Abnormal spermatogenesis (HP:0008669)	2.51925851
40	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.51790741
41	Azoospermia (HP:0000027)	2.48718458
42	Absent thumb (HP:0009777)	2.48659380
43	Male infertility (HP:0003251)	2.47826116
44	Proximal placement of thumb (HP:0009623)	2.47496591
45	Abnormal pancreas size (HP:0012094)	2.43425053
46	Self-mutilation (HP:0000742)	2.42203202
47	Abnormality of the proximal phalanges of the hand (HP:0009834)	2.40208786
48	Deviation of the thumb (HP:0009603)	2.38285645
49	Glossoptosis (HP:0000162)	2.37844417
50	Male pseudohermaphroditism (HP:0000037)	2.35087070
51	Carpal bone hypoplasia (HP:0001498)	2.34405974
52	Onycholysis (HP:0001806)	2.34119224
53	Morphological abnormality of the inner ear (HP:0011390)	2.33665444
54	Absent radius (HP:0003974)	2.32668826
55	Metaphyseal cupping (HP:0003021)	2.29290286
56	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.26682525
57	Protuberant abdomen (HP:0001538)	2.24715610
58	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.22638896
59	Abnormal protein N-linked glycosylation (HP:0012347)	2.22638896
60	Abnormal protein glycosylation (HP:0012346)	2.22638896
61	Abnormal glycosylation (HP:0012345)	2.22638896
62	Postural instability (HP:0002172)	2.18186051
63	Aplasia involving forearm bones (HP:0009822)	2.16452221
64	Absent forearm bone (HP:0003953)	2.16452221
65	Hip contracture (HP:0003273)	2.15391602
66	Short thumb (HP:0009778)	2.14792725
67	Cervical subluxation (HP:0003308)	2.13514456
68	Ureteral duplication (HP:0000073)	2.13060531
69	Abnormal respiratory motile cilium physiology (HP:0012261)	2.12080606
70	Cerebral hypomyelination (HP:0006808)	2.12048579
71	Squamous cell carcinoma (HP:0002860)	2.11212339
72	Posterior subcapsular cataract (HP:0007787)	2.08372915
73	Abnormality of the intrinsic pathway (HP:0010989)	2.03895364
74	Mixed hearing impairment (HP:0000410)	2.03230993
75	Aplasia/Hypoplasia involving the musculature (HP:0001460)	2.01915541
76	Ileus (HP:0002595)	2.01552734
77	Flat capital femoral epiphysis (HP:0003370)	2.01490032
78	Chromsome breakage (HP:0040012)	2.01115925
79	Cerebellar dysplasia (HP:0007033)	1.96914200
80	Abnormality of the salivary glands (HP:0010286)	1.92649509
81	Delayed epiphyseal ossification (HP:0002663)	1.92128584
82	Unsteady gait (HP:0002317)	1.91322367
83	Irregular epiphyses (HP:0010582)	1.88590994
84	Abnormal ciliary motility (HP:0012262)	1.88169795
85	Abnormality of the preputium (HP:0100587)	1.83151235
86	Abnormality of the ileum (HP:0001549)	1.80317972
87	Abnormal hair laboratory examination (HP:0003328)	1.78983774
88	Neonatal short-limb short stature (HP:0008921)	1.78459591
89	Abnormality of DNA repair (HP:0003254)	1.77050545
90	Difficulty climbing stairs (HP:0003551)	1.75523529
91	Aplasia/Hypoplasia of the ulna (HP:0006495)	1.74737132
92	Palpitations (HP:0001962)	1.74310157
93	Slow-growing hair (HP:0002217)	1.73153224
94	Abnormality of hair growth rate (HP:0011363)	1.73153224
95	Chronic bronchitis (HP:0004469)	1.71506726
96	Premature ovarian failure (HP:0008209)	1.69475135
97	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.68992396
98	Sensory axonal neuropathy (HP:0003390)	1.68589811
99	Brittle hair (HP:0002299)	1.68393283
100	Type II lissencephaly (HP:0007260)	1.66920514

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	LATS1	7.01403928
2	PINK1	5.90765915
3	MST4	4.55334439
4	MARK3	3.81960671
5	MST1R	3.44066686
6	STK38L	2.86331533
7	ZAK	2.72423915
8	TLK1	2.54513704
9	NME2	2.26530704
10	NUAK1	2.26137924
11	PLK4	2.18861671
12	MET	2.12008862
13	MYLK	2.10516907
14	BUB1	2.08174397
15	LATS2	1.96631536
16	EPHA2	1.94896524
17	NEK2	1.91281497
18	LMTK2	1.90787074
19	MAP3K9	1.87134951
20	DDR2	1.69332117
21	MAPK15	1.68115745
22	STK3	1.58830363
23	PBK	1.34346740
24	RPS6KA5	1.28428007
25	CSNK1A1L	1.25704575
26	PNCK	1.23468467
27	EIF2AK3	1.20342194
28	CSNK1G3	1.18228488
29	RPS6KA4	1.12408770
30	VRK1	1.11234541
31	SRPK1	1.08488110
32	STK38	1.07539599
33	ARAF	1.05018686
34	STK24	0.96722658
35	WEE1	0.89813710
36	CDK3	0.89162182
37	CSNK1G1	0.87579900
38	FGR	0.83902520
39	PLK1	0.83184877
40	MAP3K13	0.77760753
41	CSNK1G2	0.75035928
42	PTK2B	0.69652708
43	ILK	0.66987993
44	PRKCI	0.64841672
45	STK10	0.64213471
46	TESK2	0.64136674
47	PLK2	0.62807974
48	PKN2	0.61499338
49	BRSK1	0.56276315
50	STK16	0.54628754
51	AURKB	0.54075718
52	MAP2K7	0.50120153
53	MAP3K8	0.50028918
54	AKT2	0.47838505
55	PRKG2	0.43467731
56	TRPM7	0.43149868
57	AURKA	0.42997541
58	KDR	0.42217994
59	MTOR	0.42110842
60	MELK	0.40863504
61	ROCK1	0.40030308
62	PLK3	0.40023962
63	NEK6	0.39993474
64	PAK1	0.39736046
65	BMX	0.39044260
66	NME1	0.38124076
67	NEK1	0.38103041
68	CDK12	0.35617363
69	PDGFRB	0.34948527
70	PRKCQ	0.34227680
71	PDK2	0.33845446
72	PTK2	0.33595920
73	WNK4	0.33441690
74	CDK14	0.33216118
75	DYRK3	0.32636714
76	CHEK1	0.32469166
77	CDC42BPA	0.32300966
78	MAP3K1	0.30832719
79	VRK2	0.30057848
80	RPS6KB2	0.29663371
81	TSSK6	0.29371875
82	CDC7	0.28335617
83	EGFR	0.28223259
84	PKN1	0.27665440
85	ATM	0.26857177
86	PAK4	0.25104295
87	CSNK1E	0.23638425
88	OXSR1	0.22620014
89	MOS	0.22400476
90	WNK1	0.21821616
91	RET	0.20709861
92	CDK7	0.20313248
93	CSNK2A1	0.20158379
94	CDK9	0.18798724
95	ATR	0.17899355
96	DAPK3	0.17432174
97	CSNK1A1	0.16787590
98	TRIM28	0.15952636
99	MAP3K10	0.15554491
100	TESK1	0.15308326

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	5.98820627
2	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	4.55956615
3	Gap junction_Homo sapiens_hsa04540	3.05033822
4	Basal transcription factors_Homo sapiens_hsa03022	2.91746920
5	Proteasome_Homo sapiens_hsa03050	2.89509850
6	DNA replication_Homo sapiens_hsa03030	2.66930527
7	Systemic lupus erythematosus_Homo sapiens_hsa05322	2.55693516
8	Oocyte meiosis_Homo sapiens_hsa04114	2.45107293
9	RNA transport_Homo sapiens_hsa03013	2.41864529
10	Cell cycle_Homo sapiens_hsa04110	2.13231588
11	mRNA surveillance pathway_Homo sapiens_hsa03015	2.12582574
12	Apoptosis_Homo sapiens_hsa04210	2.09861019
13	Olfactory transduction_Homo sapiens_hsa04740	1.99470365
14	RNA polymerase_Homo sapiens_hsa03020	1.96870512
15	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.96532740
16	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.96347525
17	Homologous recombination_Homo sapiens_hsa03440	1.94460565
18	Alcoholism_Homo sapiens_hsa05034	1.84658022
19	Fanconi anemia pathway_Homo sapiens_hsa03460	1.83776676
20	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.77057187
21	Nitrogen metabolism_Homo sapiens_hsa00910	1.57809000
22	Pyrimidine metabolism_Homo sapiens_hsa00240	1.56566378
23	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.52475464
24	Mismatch repair_Homo sapiens_hsa03430	1.52383407
25	Phototransduction_Homo sapiens_hsa04744	1.50667240
26	RNA degradation_Homo sapiens_hsa03018	1.44368332
27	Sulfur relay system_Homo sapiens_hsa04122	1.44334606
28	Regulation of autophagy_Homo sapiens_hsa04140	1.43112430
29	Phagosome_Homo sapiens_hsa04145	1.19412380
30	Spliceosome_Homo sapiens_hsa03040	1.17999465
31	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.14514614
32	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.10394767
33	Pyruvate metabolism_Homo sapiens_hsa00620	1.10154219
34	Purine metabolism_Homo sapiens_hsa00230	1.07903779
35	Asthma_Homo sapiens_hsa05310	1.03292743
36	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.02951912
37	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.97122657
38	Base excision repair_Homo sapiens_hsa03410	0.94765533
39	Propanoate metabolism_Homo sapiens_hsa00640	0.93319683
40	ECM-receptor interaction_Homo sapiens_hsa04512	0.92781359
41	Phenylalanine metabolism_Homo sapiens_hsa00360	0.90149078
42	Pentose phosphate pathway_Homo sapiens_hsa00030	0.84739301
43	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.84538841
44	Arginine biosynthesis_Homo sapiens_hsa00220	0.83928222
45	Viral carcinogenesis_Homo sapiens_hsa05203	0.82499357
46	Protein digestion and absorption_Homo sapiens_hsa04974	0.81977724
47	Nucleotide excision repair_Homo sapiens_hsa03420	0.80410312
48	Glutathione metabolism_Homo sapiens_hsa00480	0.80103045
49	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.79702025
50	Tight junction_Homo sapiens_hsa04530	0.77696378
51	Taste transduction_Homo sapiens_hsa04742	0.74886244
52	Wnt signaling pathway_Homo sapiens_hsa04310	0.74826007
53	p53 signaling pathway_Homo sapiens_hsa04115	0.69579361
54	Prostate cancer_Homo sapiens_hsa05215	0.68802415
55	Parkinsons disease_Homo sapiens_hsa05012	0.68391043
56	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.68299657
57	Folate biosynthesis_Homo sapiens_hsa00790	0.65968890
58	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.64896163
59	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.64807587
60	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.64511689
61	Ribosome_Homo sapiens_hsa03010	0.62524270
62	Gastric acid secretion_Homo sapiens_hsa04971	0.57786045
63	Small cell lung cancer_Homo sapiens_hsa05222	0.57356218
64	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.57198405
65	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.55923881
66	Chemical carcinogenesis_Homo sapiens_hsa05204	0.55667357
67	Lysine degradation_Homo sapiens_hsa00310	0.55472034
68	Huntingtons disease_Homo sapiens_hsa05016	0.54960852
69	Thyroid cancer_Homo sapiens_hsa05216	0.53193317
70	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.52112775
71	Hippo signaling pathway_Homo sapiens_hsa04390	0.52045204
72	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.51549830
73	Steroid biosynthesis_Homo sapiens_hsa00100	0.50790730
74	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.46465603
75	beta-Alanine metabolism_Homo sapiens_hsa00410	0.46460293
76	Tyrosine metabolism_Homo sapiens_hsa00350	0.45727738
77	Focal adhesion_Homo sapiens_hsa04510	0.43924758
78	Glucagon signaling pathway_Homo sapiens_hsa04922	0.43840775
79	Adherens junction_Homo sapiens_hsa04520	0.43111790
80	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.42926964
81	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.41417249
82	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.35858952
83	Herpes simplex infection_Homo sapiens_hsa05168	0.32022477
84	Metabolic pathways_Homo sapiens_hsa01100	0.30885281
85	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.29876244
86	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.29779913
87	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.28370072
88	Legionellosis_Homo sapiens_hsa05134	0.25354977
89	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.22998008
90	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.22808242
91	Melanogenesis_Homo sapiens_hsa04916	0.20943919
92	HTLV-I infection_Homo sapiens_hsa05166	0.20666902
93	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.19982181
94	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.18265921
95	Carbon metabolism_Homo sapiens_hsa01200	0.17947011
96	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.17929386
97	Sphingolipid metabolism_Homo sapiens_hsa00600	0.14453023
98	Glioma_Homo sapiens_hsa05214	0.14438032
99	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.14091740
100	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.13805442

CXORF49B

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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