ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	male meiosis (GO:0007140)	9.94844299
2	acrosome reaction (GO:0007340)	9.04340035
3	spermatid development (GO:0007286)	8.68060781
4	regulation of oxidative stress-induced neuron death (GO:1903203)	8.47374849
5	sperm motility (GO:0030317)	8.11963440
6	binding of sperm to zona pellucida (GO:0007339)	7.61526926
7	multicellular organism reproduction (GO:0032504)	7.44665582
8	regulation of oxidative phosphorylation (GO:0002082)	7.44611009
9	nucleosome disassembly (GO:0006337)	7.39915092
10	protein-DNA complex disassembly (GO:0032986)	7.39915092
11	relaxation of smooth muscle (GO:0044557)	7.27603352
12	motile cilium assembly (GO:0044458)	7.10347023
13	potassium ion export (GO:0071435)	6.90499209
14	axonemal dynein complex assembly (GO:0070286)	6.41008085
15	polyamine biosynthetic process (GO:0006596)	6.31703509
16	negative regulation of hydrogen peroxide-induced cell death (GO:1903206)	6.26805209
17	organic cation transport (GO:0015695)	6.07263765
18	cGMP-mediated signaling (GO:0019934)	6.05988797
19	Leydig cell differentiation (GO:0033327)	6.04292940
20	sperm-egg recognition (GO:0035036)	5.98646871
21	synapsis (GO:0007129)	5.92490249
22	activation of protein kinase B activity (GO:0032148)	5.90096770
23	cilium or flagellum-dependent cell motility (GO:0001539)	5.80013989
24	male sex determination (GO:0030238)	5.73251874
25	negative regulation of response to reactive oxygen species (GO:1901032)	5.71965873
26	regulation of hydrogen peroxide-induced cell death (GO:1903205)	5.67325569
27	epithelial cilium movement (GO:0003351)	5.38329130
28	cell-cell recognition (GO:0009988)	5.32174396
29	reproduction (GO:0000003)	5.19993854
30	regulation of autophagic vacuole assembly (GO:2000785)	5.19670194
31	regulation of dopamine secretion (GO:0014059)	5.18911441
32	TOR signaling (GO:0031929)	5.18066099
33	protein polymerization (GO:0051258)	5.06701357
34	glutamine family amino acid catabolic process (GO:0009065)	5.05505465
35	germ cell development (GO:0007281)	5.00238081
36	positive regulation of glycolytic process (GO:0045821)	4.98917942
37	glycogen metabolic process (GO:0005977)	4.96931982
38	glucan metabolic process (GO:0044042)	4.92670297
39	cellular glucan metabolic process (GO:0006073)	4.92670297
40	androgen biosynthetic process (GO:0006702)	4.91782336
41	regulation of cellular respiration (GO:0043457)	4.87959449
42	single fertilization (GO:0007338)	4.87824156
43	negative regulation of cardiac muscle cell apoptotic process (GO:0010667)	4.79008573
44	response to acidic pH (GO:0010447)	4.62667058
45	tongue development (GO:0043586)	4.58628694
46	mitochondrion degradation (GO:0000422)	4.47919430
47	ventricular system development (GO:0021591)	4.47353773
48	regulation of synaptic transmission, dopaminergic (GO:0032225)	4.44887981
49	histone exchange (GO:0043486)	4.40628613
50	cilium movement (GO:0003341)	4.34694158
51	coenzyme catabolic process (GO:0009109)	4.32697253
52	membrane repolarization during action potential (GO:0086011)	4.30461518
53	regulation of vacuole organization (GO:0044088)	4.28352421
54	oogenesis (GO:0048477)	4.28112052
55	acrosome assembly (GO:0001675)	4.24390098
56	cellular biogenic amine biosynthetic process (GO:0042401)	4.23407575
57	amine biosynthetic process (GO:0009309)	4.19080825
58	positive regulation of amine transport (GO:0051954)	4.08218166
59	regulation of phosphatase activity (GO:0010921)	4.03591980
60	fusion of sperm to egg plasma membrane (GO:0007342)	4.00601505
61	chromosome organization involved in meiosis (GO:0070192)	4.00140713
62	diacylglycerol metabolic process (GO:0046339)	3.99609121
63	negative regulation of inclusion body assembly (GO:0090084)	3.97954501
64	dicarboxylic acid biosynthetic process (GO:0043650)	3.97828739
65	calcium ion-dependent exocytosis (GO:0017156)	3.97729034
66	aspartate family amino acid catabolic process (GO:0009068)	3.97132604
67	cellular process involved in reproduction in multicellular organism (GO:0022412)	3.92873021
68	cellular response to toxic substance (GO:0097237)	3.89087643
69	negative regulation of JNK cascade (GO:0046329)	3.86190135
70	negative regulation of smooth muscle contraction (GO:0045986)	3.82937515
71	membrane repolarization (GO:0086009)	3.80076328
72	phosphatidylethanolamine biosynthetic process (GO:0006646)	3.78841045
73	polyamine metabolic process (GO:0006595)	3.77061601
74	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902176)	3.76856411
75	meiotic nuclear division (GO:0007126)	3.75443558
76	DNA double-strand break processing (GO:0000729)	3.72580742
77	oligosaccharide biosynthetic process (GO:0009312)	3.65688278
78	regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)	3.57812161
79	phosphatidylethanolamine metabolic process (GO:0046337)	3.45403931
80	cellular polysaccharide metabolic process (GO:0044264)	3.43759383
81	indole-containing compound catabolic process (GO:0042436)	3.39782832
82	indolalkylamine catabolic process (GO:0046218)	3.39782832
83	tryptophan catabolic process (GO:0006569)	3.39782832
84	negative regulation of stress-activated MAPK cascade (GO:0032873)	3.39005071
85	negative regulation of stress-activated protein kinase signaling cascade (GO:0070303)	3.39005071
86	histone H3-K9 demethylation (GO:0033169)	3.31115133
87	potassium ion import (GO:0010107)	3.29935341
88	fertilization (GO:0009566)	3.28169221
89	polysaccharide metabolic process (GO:0005976)	3.21200454
90	plasma membrane fusion (GO:0045026)	3.19868691
91	regulation of dephosphorylation (GO:0035303)	3.16630728
92	regulation of synaptic vesicle transport (GO:1902803)	3.15384529
93	negative regulation of reactive oxygen species metabolic process (GO:2000378)	3.14742796
94	negative regulation of striated muscle cell apoptotic process (GO:0010664)	3.08709609
95	sex determination (GO:0007530)	3.06791369
96	cellular response to pH (GO:0071467)	3.05664995
97	relaxation of muscle (GO:0090075)	3.04940383
98	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	11.8911809
99	regulation of phosphoprotein phosphatase activity (GO:0043666)	11.3147577
100	positive regulation of catecholamine secretion (GO:0033605)	10.6906506

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IGF1R_20145208_ChIP-Seq_DFB_Human	5.01235961
2	ESR1_20079471_ChIP-ChIP_T-47D_Human	4.08883907
3	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	3.21343869
4	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.95147812
5	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.66404324
6	EZH2_22144423_ChIP-Seq_EOC_Human	2.35353688
7	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.19075869
8	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.17354664
9	FUS_26573619_Chip-Seq_HEK293_Human	2.13833179
10	AHR_22903824_ChIP-Seq_MCF-7_Human	2.01891087
11	ARNT_22903824_ChIP-Seq_MCF-7_Human	2.01202249
12	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	10.6368015
13	BP1_19119308_ChIP-ChIP_Hs578T_Human	10.1364220
14	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.90827192
15	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.90827192
16	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.86529975
17	AR_21572438_ChIP-Seq_LNCaP_Human	1.83546729
18	AR_21909140_ChIP-Seq_LNCAP_Human	1.74516695
19	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.73354911
20	NANOG_20526341_ChIP-Seq_ESCs_Human	1.72240644
21	GBX2_23144817_ChIP-Seq_PC3_Human	1.71594967
22	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.69805621
23	ER_23166858_ChIP-Seq_MCF-7_Human	1.54073264
24	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.47504420
25	RAC3_21632823_ChIP-Seq_H3396_Human	1.46719917
26	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.46695445
27	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.46314516
28	CBP_20019798_ChIP-Seq_JUKART_Human	1.46314516
29	CTCF_27219007_Chip-Seq_Bcells_Human	1.45699146
30	GATA1_22025678_ChIP-Seq_K562_Human	1.42767122
31	BCAT_22108803_ChIP-Seq_LS180_Human	1.40369920
32	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.38095931
33	ERA_21632823_ChIP-Seq_H3396_Human	1.34355895
34	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.34119714
35	OCT4_20526341_ChIP-Seq_ESCs_Human	1.33341154
36	SMC4_20622854_ChIP-Seq_HELA_Human	1.31731137
37	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.31216478
38	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.28754294
39	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.26299121
40	TBL1_22424771_ChIP-Seq_293T_Human	1.25883607
41	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.24665924
42	TP53_18474530_ChIP-ChIP_U2OS_Human	1.24205619
43	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.23544980
44	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.21944548
45	MYC_19829295_ChIP-Seq_ESCs_Human	1.19672335
46	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.19114343
47	ERG_20517297_ChIP-Seq_VCAP_Human	1.18769268
48	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.15221994
49	RUNX2_22187159_ChIP-Seq_PCA_Human	1.12476946
50	VDR_22108803_ChIP-Seq_LS180_Human	1.11371812
51	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.11325821
52	P300_19829295_ChIP-Seq_ESCs_Human	1.09557705
53	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.07570330
54	SMAD4_21799915_ChIP-Seq_A2780_Human	1.05417606
55	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.05345479
56	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	1.05041209
57	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.04324736
58	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.04275775
59	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	0.96581440
60	RXR_22108803_ChIP-Seq_LS180_Human	0.95896755
61	SPI1_20517297_ChIP-Seq_HL60_Human	0.95194946
62	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.95123956
63	CTCF_20526341_ChIP-Seq_ESCs_Human	0.94795231
64	SOX2_19829295_ChIP-Seq_ESCs_Human	0.94627272
65	NANOG_19829295_ChIP-Seq_ESCs_Human	0.94627272
66	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.94423640
67	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.94245440
68	ZNF263_19887448_ChIP-Seq_K562_Human	0.94010179
69	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.92846190
70	AR_25329375_ChIP-Seq_VCAP_Human	0.91112876
71	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.91009492
72	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.90849709
73	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.87987926
74	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	0.86001022
75	PKCTHETA_26484144_Chip-Seq_BREAST_Human	0.85728543
76	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.83299539
77	TFAP2A_17053090_ChIP-ChIP_MCF-7_Human	0.83255870
78	PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse	0.83143389
79	ELF5_23300383_ChIP-Seq_T47D_Human	0.82486339
80	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.82409506
81	GF1B_26923725_Chip-Seq_HPCs_Mouse	0.81686170
82	P300_27268052_Chip-Seq_Bcells_Human	0.81276356
83	HOXB7_26014856_ChIP-Seq_BT474_Human	0.80906611
84	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.80394083
85	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.77220087
86	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.77148984
87	PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	0.77037696
88	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.76545249
89	ESET_19884257_ChIP-Seq_ESCs_Mouse	0.75592486
90	IRF1_19129219_ChIP-ChIP_H3396_Human	0.75506930
91	LXR_22292898_ChIP-Seq_THP-1_Human	0.75288435
92	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.74654571
93	STAT3_23295773_ChIP-Seq_U87_Human	0.73984622
94	E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.73681075
95	GF1_26923725_Chip-Seq_HPCs_Mouse	0.73276492
96	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	0.73220991
97	PHF8_20622854_ChIP-Seq_HELA_Human	0.72829302
98	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.72460777
99	STAT1_17558387_ChIP-Seq_HELA_Human	0.72375372
100	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.72102333

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	9.21193583
2	MP0003315_abnormal_perineum_morphology	7.60817990
3	MP0008004_abnormal_stomach_pH	6.75912660
4	MP0005360_urolithiasis	4.13904097
5	MP0002160_abnormal_reproductive_system	3.82867178
6	MP0003045_fibrosis	3.10774048
7	MP0003698_abnormal_male_reproductive	3.10296726
8	MP0005058_abnormal_lysosome_morphology	3.03588754
9	MP0000537_abnormal_urethra_morphology	2.86193679
10	MP0001929_abnormal_gametogenesis	2.77522671
11	MP0002132_abnormal_respiratory_system	2.43949861
12	MP0001984_abnormal_olfaction	2.42751228
13	MP0003136_yellow_coat_color	2.39589212
14	MP0010386_abnormal_urinary_bladder	2.39145846
15	MP0005647_abnormal_sex_gland	2.35008671
16	MP0001664_abnormal_digestion	2.14753345
17	MP0010368_abnormal_lymphatic_system	2.09482911
18	MP0005499_abnormal_olfactory_system	2.08496580
19	MP0005394_taste/olfaction_phenotype	2.08496580
20	MP0005187_abnormal_penis_morphology	1.97196977
21	MP0005389_reproductive_system_phenotype	1.80513971
22	MP0000538_abnormal_urinary_bladder	1.79198660
23	MP0001188_hyperpigmentation	1.73261162
24	MP0001905_abnormal_dopamine_level	1.60718786
25	MP0002161_abnormal_fertility/fecundity	1.59447296
26	MP0006072_abnormal_retinal_apoptosis	1.55537361
27	MP0008995_early_reproductive_senescence	1.55365606
28	MP0002210_abnormal_sex_determination	1.54941682
29	MP0000465_gastrointestinal_hemorrhage	1.52691805
30	MP0001145_abnormal_male_reproductive	1.44436681
31	MP0001849_ear_inflammation	1.42314686
32	MP0009697_abnormal_copulation	1.29854606
33	MP0004272_abnormal_basement_membrane	1.29076186
34	MP0000653_abnormal_sex_gland	1.27942211
35	MP0003632_abnormal_nervous_system	1.13090607
36	MP0000343_altered_response_to	1.11586261
37	MP0005409_darkened_coat_color	1.08009224
38	MP0003718_maternal_effect	1.04944759
39	MP0006036_abnormal_mitochondrial_physio	1.03499097
40	MP0005646_abnormal_pituitary_gland	1.02553609
41	MP0005248_abnormal_Harderian_gland	1.01002983
42	MP0005395_other_phenotype	1.00636561
43	MP0003936_abnormal_reproductive_system	0.99467507
44	MP0001501_abnormal_sleep_pattern	0.98258228
45	MP0002127_abnormal_cardiovascular_syste	0.97476226
46	MP0002168_other_aberrant_phenotype	0.95714654
47	MP0001919_abnormal_reproductive_system	0.95147969
48	MP0004084_abnormal_cardiac_muscle	0.90354095
49	MP0004085_abnormal_heartbeat	0.86048167
50	MP0003631_nervous_system_phenotype	0.85937199
51	MP0000470_abnormal_stomach_morphology	0.85189742
52	MP0001529_abnormal_vocalization	0.81240451
53	MP0002249_abnormal_larynx_morphology	0.79272508
54	MP0003806_abnormal_nucleotide_metabolis	0.76136596
55	MP0002233_abnormal_nose_morphology	0.75781005
56	MP0000631_abnormal_neuroendocrine_gland	0.74972538
57	MP0008789_abnormal_olfactory_epithelium	0.74740054
58	MP0010234_abnormal_vibrissa_follicle	0.74445692
59	MP0005253_abnormal_eye_physiology	0.72765355
60	MP0002102_abnormal_ear_morphology	0.70698588
61	MP0004381_abnormal_hair_follicle	0.69057132
62	MP0005174_abnormal_tail_pigmentation	0.67760359
63	MP0001661_extended_life_span	0.66863350
64	MP0004036_abnormal_muscle_relaxation	0.64887560
65	MP0000678_abnormal_parathyroid_gland	0.61328381
66	MP0003633_abnormal_nervous_system	0.60976676
67	MP0002998_abnormal_bone_remodeling	0.59542622
68	MP0000230_abnormal_systemic_arterial	0.58170664
69	MP0003385_abnormal_body_wall	0.57727139
70	MP0005595_abnormal_vascular_smooth	0.55615780
71	MP0003879_abnormal_hair_cell	0.55380910
72	MP0002638_abnormal_pupillary_reflex	0.55075639
73	MP0001270_distended_abdomen	0.53135958
74	MP0003938_abnormal_ear_development	0.52427553
75	MP0005620_abnormal_muscle_contractility	0.51990427
76	MP0002272_abnormal_nervous_system	0.51606320
77	MP0002090_abnormal_vision	0.51075577
78	MP0001756_abnormal_urination	0.50810273
79	MP0003868_abnormal_feces_composition	0.48699389
80	MP0005166_decreased_susceptibility_to	0.46245995
81	MP0009840_abnormal_foam_cell	0.45264041
82	MP0004782_abnormal_surfactant_physiolog	0.44446112
83	MP0003635_abnormal_synaptic_transmissio	0.42905341
84	MP0000762_abnormal_tongue_morphology	0.41117687
85	MP0000462_abnormal_digestive_system	0.39301672
86	MP0000049_abnormal_middle_ear	0.38377325
87	MP0000747_muscle_weakness	0.38072330
88	MP0000920_abnormal_myelination	0.37601163
89	MP0002752_abnormal_somatic_nervous	0.36585255
90	MP0009250_abnormal_appendicular_skeleto	0.35735843
91	MP0005391_vision/eye_phenotype	0.35688065
92	MP0002115_abnormal_skeleton_extremities	0.35010803
93	MP0004484_altered_response_of	0.33080687
94	MP0002277_abnormal_respiratory_mucosa	0.33066097
95	MP0004859_abnormal_synaptic_plasticity	0.31886680
96	MP0001968_abnormal_touch/_nociception	0.31791987
97	MP0001764_abnormal_homeostasis	0.31723473
98	MP0000026_abnormal_inner_ear	0.31318301
99	MP0002282_abnormal_trachea_morphology	0.30847989
100	MP0001485_abnormal_pinna_reflex	0.29833247

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Sex reversal (HP:0012245)	8.61016468
2	Abnormal sex determination (HP:0012244)	8.61016468
3	Hypoplasia of the uterus (HP:0000013)	7.74934958
4	Resting tremor (HP:0002322)	7.67973718
5	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	6.32520330
6	Gonadal dysgenesis (HP:0000133)	5.95800871
7	Abnormality of the columella (HP:0009929)	5.83932635
8	Aplasia/hypoplasia of the uterus (HP:0008684)	5.82312200
9	Reduced antithrombin III activity (HP:0001976)	5.77693258
10	Absent/shortened dynein arms (HP:0200106)	5.50087414
11	Dynein arm defect of respiratory motile cilia (HP:0012255)	5.50087414
12	Abnormal respiratory motile cilium physiology (HP:0012261)	5.46298234
13	Colitis (HP:0002583)	5.32883667
14	Abnormal ciliary motility (HP:0012262)	5.24218391
15	Male pseudohermaphroditism (HP:0000037)	4.83718235
16	Postural instability (HP:0002172)	4.76529720
17	Germ cell neoplasia (HP:0100728)	4.71437563
18	Ventricular fibrillation (HP:0001663)	4.70589295
19	Facial hemangioma (HP:0000329)	4.65190637
20	Infertility (HP:0000789)	4.49685407
21	Abnormal respiratory motile cilium morphology (HP:0005938)	4.15594752
22	Abnormal respiratory epithelium morphology (HP:0012253)	4.15594752
23	Thoracic kyphosis (HP:0002942)	4.15175603
24	Cerebellar dysplasia (HP:0007033)	4.10818034
25	Urinary urgency (HP:0000012)	4.03596968
26	Thoracolumbar scoliosis (HP:0002944)	3.96942779
27	Self-mutilation (HP:0000742)	3.50448898
28	Abnormality of the intrinsic pathway (HP:0010989)	3.49679918
29	Inflammation of the large intestine (HP:0002037)	3.45819585
30	Type II lissencephaly (HP:0007260)	3.43863632
31	Abnormality of the lumbar spine (HP:0100712)	3.29048974
32	Retinal atrophy (HP:0001105)	3.25550156
33	Capillary hemangiomas (HP:0005306)	3.24032009
34	Gastrointestinal inflammation (HP:0004386)	3.20224002
35	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	3.18933550
36	Protruding tongue (HP:0010808)	3.12064858
37	Rhinitis (HP:0012384)	3.11501481
38	Nasal polyposis (HP:0100582)	3.08753821
39	Retinal dysplasia (HP:0007973)	3.02272741
40	Atonic seizures (HP:0010819)	2.91252988
41	Abnormality of the nasal mucosa (HP:0000433)	2.75966452
42	Sensory axonal neuropathy (HP:0003390)	2.73586853
43	Abnormality of the thoracic spine (HP:0100711)	2.71560117
44	Abnormality of male internal genitalia (HP:0000022)	2.70183173
45	Occipital encephalocele (HP:0002085)	2.62667477
46	Buphthalmos (HP:0000557)	2.58157448
47	Abnormality of the frontal sinuses (HP:0002687)	2.54937763
48	Congenital sensorineural hearing impairment (HP:0008527)	2.54289572
49	Aplasia/Hypoplasia involving the sinuses (HP:0009120)	2.53575968
50	Unsteady gait (HP:0002317)	2.40177519
51	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.39794269
52	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.39794269
53	Chronic bronchitis (HP:0004469)	2.38816281
54	Anterior segment dysgenesis (HP:0007700)	2.36433468
55	Decreased number of peripheral myelinated nerve fibers (HP:0003380)	2.35825389
56	Hypothermia (HP:0002045)	2.34219716
57	Inability to walk (HP:0002540)	2.31790423
58	Bronchiectasis (HP:0002110)	2.31257730
59	Absent thumb (HP:0009777)	2.29547425
60	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.28227694
61	Syncope (HP:0001279)	2.26240550
62	Prolonged QT interval (HP:0001657)	2.25759932
63	Facial diplegia (HP:0001349)	2.23291092
64	Spinal rigidity (HP:0003306)	2.21405146
65	Aortic aneurysm (HP:0004942)	2.05689096
66	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	2.05458099
67	Polyneuropathy (HP:0001271)	2.03146815
68	High anterior hairline (HP:0009890)	1.95332788
69	Coxa valga (HP:0002673)	1.93539562
70	Centrally nucleated skeletal muscle fibers (HP:0003687)	1.90887461
71	Absent speech (HP:0001344)	1.89235127
72	Abnormality of the ileum (HP:0001549)	1.88621702
73	Chronic sinusitis (HP:0011109)	1.87983592
74	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.85635522
75	Abnormal protein N-linked glycosylation (HP:0012347)	1.85635522
76	Abnormal protein glycosylation (HP:0012346)	1.85635522
77	Abnormal glycosylation (HP:0012345)	1.85635522
78	Generalized hypotonia (HP:0001290)	1.83899249
79	Difficulty climbing stairs (HP:0003551)	1.82286577
80	Aplasia cutis congenita (HP:0001057)	1.80198317
81	Optic nerve hypoplasia (HP:0000609)	1.75826090
82	Vitreoretinal degeneration (HP:0000655)	1.73049519
83	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.72033629
84	Renal dysplasia (HP:0000110)	1.68455716
85	Depression (HP:0000716)	1.67498123
86	Meckel diverticulum (HP:0002245)	1.64226077
87	Atrial fibrillation (HP:0005110)	1.64098104
88	Bradykinesia (HP:0002067)	1.63678719
89	Flattened epiphyses (HP:0003071)	1.61553424
90	Median cleft lip (HP:0000161)	1.60509760
91	Exercise-induced myalgia (HP:0003738)	1.60405979
92	Anxiety (HP:0000739)	1.58391684
93	Intellectual disability, progressive (HP:0006887)	1.56297135
94	Congenital glaucoma (HP:0001087)	1.53392220
95	Squamous cell carcinoma (HP:0002860)	1.52785992
96	Aplasia/Hypoplasia of the brainstem (HP:0007362)	1.52652657
97	Hypoplasia of the brainstem (HP:0002365)	1.52652657
98	Tubulointerstitial nephritis (HP:0001970)	1.52278503
99	Enlarged kidneys (HP:0000105)	1.52014471
100	High pitched voice (HP:0001620)	1.49866334

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MARK3	6.46255948
2	TLK1	4.00439183
3	ZAK	3.91723986
4	MYLK	3.39814277
5	RPS6KA5	3.00561852
6	NEK2	2.32063961
7	LATS1	2.11137135
8	PINK1	12.2330761
9	STK38	1.59379965
10	MAP2K7	1.32184789
11	STK38L	1.28262309
12	CDK3	1.18855258
13	LATS2	1.11926684
14	MST1R	1.08596932
15	SGK223	1.06501487
16	SGK494	1.06501487
17	FRK	0.93492013
18	MAPK15	0.93125960
19	CDC42BPA	0.91944983
20	CSNK1A1L	0.91169878
21	MAP3K9	0.87974616
22	PRKCQ	0.86008708
23	ARAF	0.83437721
24	DYRK3	0.82384053
25	VRK1	0.81217024
26	CDK14	0.79097031
27	CSNK1G3	0.73236443
28	BMPR1B	0.71953452
29	OBSCN	0.69137195
30	MELK	0.68681871
31	MAP3K13	0.66671760
32	FGR	0.65929922
33	MAP3K1	0.61019702
34	FGFR2	0.57245891
35	CSNK1G1	0.57024599
36	PAK1	0.53469856
37	PAK2	0.53365599
38	EIF2AK3	0.52313128
39	CSNK1G2	0.51139022
40	DAPK3	0.50296920
41	DYRK2	0.49849089
42	MAP3K5	0.49424210
43	PKN1	0.48143938
44	PRKG2	0.45403419
45	MAP3K10	0.44682394
46	ROCK1	0.43237393
47	TIE1	0.42595501
48	CDK5	0.42212203
49	NME2	0.40683907
50	TGFBR1	0.40162514
51	RET	0.40031925
52	RPS6KB1	0.38955154
53	EGFR	0.38847429
54	MOS	0.35822053
55	CAMK1	0.35731944
56	PDPK1	0.34580484
57	ATM	0.34393447
58	EEF2K	0.33746861
59	PRKG1	0.30521116
60	PTK2B	0.28096618
61	ILK	0.26863209
62	FES	0.26413801
63	ADRBK2	0.25481159
64	PRKD3	0.24824908
65	SGK2	0.24408787
66	CDK8	0.23975562
67	PKN2	0.23847530
68	MTOR	0.22755952
69	CSNK1A1	0.22574818
70	ICK	0.22199659
71	CLK1	0.22056365
72	BRAF	0.21649951
73	AKT2	0.21456700
74	PDK1	0.20468959
75	RPS6KA1	0.19396459
76	GRK1	0.18897243
77	RPS6KA4	0.18307186
78	STK3	0.18192977
79	MAPK12	0.18108304
80	RPS6KA3	0.18011207
81	GRK6	0.16735217
82	CDK12	0.16284274
83	BTK	0.15977592
84	IRAK2	0.15066277
85	AURKB	0.14407765
86	CCNB1	0.13948786
87	MINK1	0.13084052
88	MET	0.13071915
89	MAPK1	0.12652811
90	PIM1	0.07877480
91	PLK1	0.06359086
92	KSR2	0.05979652
93	WNK1	0.04375088
94	STK4	0.04323940
95	AURKA	0.04072254
96	CSNK1D	0.03315006
97	SGK3	0.03176663
98	GRK5	0.01967412
99	NLK	0.00060342
100	WNK3	-0.0001595

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	8.60695172
2	Gap junction_Homo sapiens_hsa04540	5.71977343
3	Hedgehog signaling pathway_Homo sapiens_hsa04340	3.54630912
4	Systemic lupus erythematosus_Homo sapiens_hsa05322	3.50709919
5	Nitrogen metabolism_Homo sapiens_hsa00910	3.38342181
6	Apoptosis_Homo sapiens_hsa04210	3.25391942
7	Phagosome_Homo sapiens_hsa04145	3.12159388
8	Arginine biosynthesis_Homo sapiens_hsa00220	2.63817536
9	Alcoholism_Homo sapiens_hsa05034	2.60853442
10	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	2.30269339
11	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	2.11018086
12	Olfactory transduction_Homo sapiens_hsa04740	2.10375208
13	Propanoate metabolism_Homo sapiens_hsa00640	2.04391054
14	Butanoate metabolism_Homo sapiens_hsa00650	1.60213284
15	Pyruvate metabolism_Homo sapiens_hsa00620	1.55032260
16	Glutathione metabolism_Homo sapiens_hsa00480	1.49347119
17	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.34469817
18	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.33010081
19	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.31115798
20	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.19239961
21	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.08827475
22	Glucagon signaling pathway_Homo sapiens_hsa04922	1.06371232
23	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.04688526
24	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.02571861
25	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.93654684
26	Chemical carcinogenesis_Homo sapiens_hsa05204	0.90624100
27	Pentose phosphate pathway_Homo sapiens_hsa00030	0.87852480
28	Oocyte meiosis_Homo sapiens_hsa04114	0.87400102
29	Phenylalanine metabolism_Homo sapiens_hsa00360	0.86181929
30	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.85552502
31	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.84168881
32	PPAR signaling pathway_Homo sapiens_hsa03320	0.81180502
33	Renin secretion_Homo sapiens_hsa04924	0.78570860
34	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.76406625
35	Taste transduction_Homo sapiens_hsa04742	0.73422775
36	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.72760662
37	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.71791766
38	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.68894519
39	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.67147790
40	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.66388765
41	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.61598382
42	Circadian rhythm_Homo sapiens_hsa04710	0.58729127
43	mRNA surveillance pathway_Homo sapiens_hsa03015	0.58634631
44	Tryptophan metabolism_Homo sapiens_hsa00380	0.58077722
45	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.57219963
46	Gastric acid secretion_Homo sapiens_hsa04971	0.55843903
47	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.52933176
48	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.51937745
49	Basal transcription factors_Homo sapiens_hsa03022	0.50185474
50	Fatty acid degradation_Homo sapiens_hsa00071	0.49296194
51	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.48541420
52	Endometrial cancer_Homo sapiens_hsa05213	0.42422590
53	Wnt signaling pathway_Homo sapiens_hsa04310	0.42289360
54	Tyrosine metabolism_Homo sapiens_hsa00350	0.40985672
55	beta-Alanine metabolism_Homo sapiens_hsa00410	0.37733174
56	Purine metabolism_Homo sapiens_hsa00230	0.37650726
57	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.37267555
58	Calcium signaling pathway_Homo sapiens_hsa04020	0.35531730
59	Choline metabolism in cancer_Homo sapiens_hsa05231	0.30629858
60	Fanconi anemia pathway_Homo sapiens_hsa03460	0.30385876
61	Estrogen signaling pathway_Homo sapiens_hsa04915	0.29015939
62	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.27002655
63	Circadian entrainment_Homo sapiens_hsa04713	0.26778265
64	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.25464957
65	Long-term potentiation_Homo sapiens_hsa04720	0.25440857
66	Prostate cancer_Homo sapiens_hsa05215	0.25136401
67	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.24445060
68	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.23638175
69	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.23056614
70	ECM-receptor interaction_Homo sapiens_hsa04512	0.22007651
71	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.21326349
72	Sphingolipid metabolism_Homo sapiens_hsa00600	0.19446116
73	Viral carcinogenesis_Homo sapiens_hsa05203	0.19392008
74	Carbon metabolism_Homo sapiens_hsa01200	0.19050169
75	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.17594581
76	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.17247908
77	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.17037932
78	Metabolic pathways_Homo sapiens_hsa01100	0.16907322
79	MAPK signaling pathway_Homo sapiens_hsa04010	0.16721137
80	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.16245469
81	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.16174691
82	FoxO signaling pathway_Homo sapiens_hsa04068	0.15840957
83	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.15691610
84	Amphetamine addiction_Homo sapiens_hsa05031	0.13813902
85	Focal adhesion_Homo sapiens_hsa04510	0.13731275
86	Melanoma_Homo sapiens_hsa05218	0.13680355
87	RNA transport_Homo sapiens_hsa03013	0.12861678
88	RNA degradation_Homo sapiens_hsa03018	0.12558131
89	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.11691524
90	Retinol metabolism_Homo sapiens_hsa00830	0.11632723
91	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.09544183
92	Regulation of autophagy_Homo sapiens_hsa04140	0.09160274
93	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.08821970
94	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.08363566
95	mTOR signaling pathway_Homo sapiens_hsa04150	0.08118271
96	Fatty acid metabolism_Homo sapiens_hsa01212	0.07922187
97	AMPK signaling pathway_Homo sapiens_hsa04152	0.07392947
98	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.05828266
99	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.05618317
100	Peroxisome_Homo sapiens_hsa04146	0.05527809

CXORF51B

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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