CXORF56

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: While this gene is well-supported by transcript data, no functional information on its protein products is currently available. Three transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of protein localization to mitochondrial membrane (GO:0090151)4.63874424
2response to pheromone (GO:0019236)4.23597550
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.99381610
4respiratory chain complex IV assembly (GO:0008535)3.89233298
5proteasome assembly (GO:0043248)3.88398174
6water-soluble vitamin biosynthetic process (GO:0042364)3.86181264
7protein complex biogenesis (GO:0070271)3.81817163
8peptidyl-histidine modification (GO:0018202)3.78294523
9mitochondrial respiratory chain complex assembly (GO:0033108)3.77779554
10behavioral response to nicotine (GO:0035095)3.73841093
11L-fucose catabolic process (GO:0042355)3.70778270
12fucose catabolic process (GO:0019317)3.70778270
13L-fucose metabolic process (GO:0042354)3.70778270
14ATP synthesis coupled proton transport (GO:0015986)3.65510459
15energy coupled proton transport, down electrochemical gradient (GO:0015985)3.65510459
16mitochondrial respiratory chain complex I assembly (GO:0032981)3.52599113
17NADH dehydrogenase complex assembly (GO:0010257)3.52599113
18mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.52599113
19RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.51239276
20tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.51239276
21replication fork processing (GO:0031297)3.50937549
22nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.43441009
23mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.43018113
24cytochrome complex assembly (GO:0017004)3.41343193
25regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.41325404
26regulation of mitotic spindle checkpoint (GO:1903504)3.41325404
27exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.41315618
28pseudouridine synthesis (GO:0001522)3.39782434
29protein-cofactor linkage (GO:0018065)3.32597744
30DNA double-strand break processing (GO:0000729)3.27408887
31regulation of nuclear cell cycle DNA replication (GO:0033262)3.24316131
32DNA deamination (GO:0045006)3.23162626
33maturation of 5.8S rRNA (GO:0000460)3.19108197
34negative regulation of DNA-dependent DNA replication (GO:2000104)3.17720094
35regulation of mitochondrial translation (GO:0070129)3.15492370
36electron transport chain (GO:0022900)3.11528341
37piRNA metabolic process (GO:0034587)3.10236384
38protein K6-linked ubiquitination (GO:0085020)3.09540240
39tRNA processing (GO:0008033)3.08096276
40respiratory electron transport chain (GO:0022904)3.06354435
41DNA replication checkpoint (GO:0000076)3.02530690
42recombinational repair (GO:0000725)3.01802612
43double-strand break repair via homologous recombination (GO:0000724)3.00913668
44transcription elongation from RNA polymerase III promoter (GO:0006385)2.97425780
45termination of RNA polymerase III transcription (GO:0006386)2.97425780
46chromatin remodeling at centromere (GO:0031055)2.94072857
47RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.90757191
48mitochondrial RNA metabolic process (GO:0000959)2.89938921
49platelet dense granule organization (GO:0060155)2.88751999
50maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.87900625
51CENP-A containing nucleosome assembly (GO:0034080)2.86735743
52intracellular protein transmembrane import (GO:0044743)2.85118317
53indolalkylamine metabolic process (GO:0006586)2.85111706
54regulation of glucokinase activity (GO:0033131)2.85050423
55regulation of hexokinase activity (GO:1903299)2.85050423
56tryptophan catabolic process (GO:0006569)2.83721473
57indole-containing compound catabolic process (GO:0042436)2.83721473
58indolalkylamine catabolic process (GO:0046218)2.83721473
59signal peptide processing (GO:0006465)2.83061533
60protein neddylation (GO:0045116)2.80765765
61somatic hypermutation of immunoglobulin genes (GO:0016446)2.79883524
62somatic diversification of immune receptors via somatic mutation (GO:0002566)2.79883524
63kynurenine metabolic process (GO:0070189)2.78617046
64rRNA modification (GO:0000154)2.78548989
65tRNA metabolic process (GO:0006399)2.74556402
66mannosylation (GO:0097502)2.73684053
67detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.73675063
68inner mitochondrial membrane organization (GO:0007007)2.72082419
69chaperone-mediated protein transport (GO:0072321)2.69960798
70somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.68338631
71isotype switching (GO:0045190)2.68338631
72somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.68338631
73preassembly of GPI anchor in ER membrane (GO:0016254)2.65504774
74synapsis (GO:0007129)2.64896649
75cullin deneddylation (GO:0010388)2.64855497
76cellular ketone body metabolic process (GO:0046950)2.64628477
77histone exchange (GO:0043486)2.64367459
78protein deneddylation (GO:0000338)2.63528104
79positive regulation of prostaglandin secretion (GO:0032308)2.62664829
80detection of light stimulus involved in sensory perception (GO:0050962)2.62562768
81detection of light stimulus involved in visual perception (GO:0050908)2.62562768
82rRNA catabolic process (GO:0016075)2.61086296
83tryptophan metabolic process (GO:0006568)2.61015511
84regulation of hippo signaling (GO:0035330)2.60502679
85nonmotile primary cilium assembly (GO:0035058)2.60067190
86rRNA methylation (GO:0031167)2.58949325
87tRNA modification (GO:0006400)2.55196570
88negative regulation of telomere maintenance (GO:0032205)2.51903588
89ketone body metabolic process (GO:1902224)2.51828347
90DNA methylation involved in gamete generation (GO:0043046)2.50987268
91centriole replication (GO:0007099)2.50719842
92DNA replication-dependent nucleosome organization (GO:0034723)2.49457891
93DNA replication-dependent nucleosome assembly (GO:0006335)2.49457891
94rRNA processing (GO:0006364)2.47512461
95rRNA metabolic process (GO:0016072)2.47487287
96L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.47377595
97ncRNA metabolic process (GO:0034660)2.46834402
98hydrogen ion transmembrane transport (GO:1902600)2.44239132
99DNA catabolic process, exonucleolytic (GO:0000738)2.43700594
100somatic diversification of immunoglobulins (GO:0016445)2.42386087

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.20435608
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.94166732
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.59370093
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.44615755
5ZNF274_21170338_ChIP-Seq_K562_Hela3.30173959
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.25741348
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.00591180
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.74691044
9ELK1_19687146_ChIP-ChIP_HELA_Human2.73760863
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.68285235
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.65149820
12E2F7_22180533_ChIP-Seq_HELA_Human2.53521633
13VDR_23849224_ChIP-Seq_CD4+_Human2.52229865
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.51129937
15VDR_22108803_ChIP-Seq_LS180_Human2.44648848
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.33875919
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.28595004
18NOTCH1_21737748_ChIP-Seq_TLL_Human2.25825587
19EWS_26573619_Chip-Seq_HEK293_Human2.22482775
20HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.21884174
21MYC_18940864_ChIP-ChIP_HL60_Human2.13975935
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.12646781
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.08910323
24* FOXP3_21729870_ChIP-Seq_TREG_Human1.98420391
25FUS_26573619_Chip-Seq_HEK293_Human1.95102173
26SRF_21415370_ChIP-Seq_HL-1_Mouse1.93265686
27FLI1_27457419_Chip-Seq_LIVER_Mouse1.90276561
28CREB1_15753290_ChIP-ChIP_HEK293T_Human1.89121986
29IGF1R_20145208_ChIP-Seq_DFB_Human1.80682363
30POU3F2_20337985_ChIP-ChIP_501MEL_Human1.75184643
31PADI4_21655091_ChIP-ChIP_MCF-7_Human1.74798242
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.71217695
33ELF1_17652178_ChIP-ChIP_JURKAT_Human1.70755989
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.67918392
35MYC_18555785_ChIP-Seq_MESCs_Mouse1.63659633
36FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.63527228
37FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.53342489
38IRF1_19129219_ChIP-ChIP_H3396_Human1.52988896
39TP53_22573176_ChIP-Seq_HFKS_Human1.50665181
40EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.49176702
41P300_19829295_ChIP-Seq_ESCs_Human1.45845675
42GBX2_23144817_ChIP-Seq_PC3_Human1.44593013
43ER_23166858_ChIP-Seq_MCF-7_Human1.44582073
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.38158085
45PCGF2_27294783_Chip-Seq_ESCs_Mouse1.38071004
46CTBP1_25329375_ChIP-Seq_LNCAP_Human1.37053038
47TTF2_22483619_ChIP-Seq_HELA_Human1.36892528
48PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.36436258
49GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.36085585
50GABP_19822575_ChIP-Seq_HepG2_Human1.34872488
51YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.34118658
52DCP1A_22483619_ChIP-Seq_HELA_Human1.29781541
53MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.26366500
54TAF15_26573619_Chip-Seq_HEK293_Human1.24319553
55FOXA1_27270436_Chip-Seq_PROSTATE_Human1.23584583
56FOXA1_25329375_ChIP-Seq_VCAP_Human1.23584583
57MYC_19030024_ChIP-ChIP_MESCs_Mouse1.22997994
58THAP11_20581084_ChIP-Seq_MESCs_Mouse1.22377256
59KDM5A_27292631_Chip-Seq_BREAST_Human1.21741275
60HOXB4_20404135_ChIP-ChIP_EML_Mouse1.20817607
61GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.19931344
62HOXB7_26014856_ChIP-Seq_BT474_Human1.11204068
63NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.10176105
64MYC_18358816_ChIP-ChIP_MESCs_Mouse1.10015543
65TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07624032
66CBP_20019798_ChIP-Seq_JUKART_Human1.07178553
67IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07178553
68CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.07098850
69AR_20517297_ChIP-Seq_VCAP_Human1.06612559
70KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.05736712
71E2F1_18555785_ChIP-Seq_MESCs_Mouse1.04262662
72E2F1_21310950_ChIP-Seq_MCF-7_Human1.03375909
73UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01715931
74NFE2_27457419_Chip-Seq_LIVER_Mouse0.98799394
75NCOR_22424771_ChIP-Seq_293T_Human0.97734798
76POU5F1_16153702_ChIP-ChIP_HESCs_Human0.97052540
77AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96924065
78SOX2_19829295_ChIP-Seq_ESCs_Human0.95302710
79NANOG_19829295_ChIP-Seq_ESCs_Human0.95302710
80YY1_21170310_ChIP-Seq_MESCs_Mouse0.94724974
81* ELK1_22589737_ChIP-Seq_MCF10A_Human0.94143939
82EZH2_27294783_Chip-Seq_NPCs_Mouse0.93555261
83SUZ12_27294783_Chip-Seq_NPCs_Mouse0.93408878
84BCAT_22108803_ChIP-Seq_LS180_Human0.93210561
85ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92896350
86POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.92735914
87XRN2_22483619_ChIP-Seq_HELA_Human0.92723291
88HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.90911630
89MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.90665711
90FOXA1_21572438_ChIP-Seq_LNCaP_Human0.89223772
91RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.88335107
92NELFA_20434984_ChIP-Seq_ESCs_Mouse0.87493314
93EGR1_23403033_ChIP-Seq_LIVER_Mouse0.85915169
94AR_25329375_ChIP-Seq_VCAP_Human0.85434516
95STAT3_23295773_ChIP-Seq_U87_Human0.84663345
96* GATA3_21878914_ChIP-Seq_MCF-7_Human0.84653233
97EZH2_22144423_ChIP-Seq_EOC_Human0.84541972
98SOX2_16153702_ChIP-ChIP_HESCs_Human0.84128702
99MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.83079297
100KLF5_20875108_ChIP-Seq_MESCs_Mouse0.82160194

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.38537797
2MP0008058_abnormal_DNA_repair2.95488989
3MP0003136_yellow_coat_color2.79164151
4MP0000372_irregular_coat_pigmentation2.71157603
5MP0010094_abnormal_chromosome_stability2.42705279
6MP0006072_abnormal_retinal_apoptosis2.35760582
7MP0003718_maternal_effect2.17682146
8MP0002837_dystrophic_cardiac_calcinosis2.16734366
9MP0003693_abnormal_embryo_hatching2.12948846
10MP0006292_abnormal_olfactory_placode2.11294585
11MP0003195_calcinosis2.10023615
12MP0004147_increased_porphyrin_level2.09081268
13MP0003787_abnormal_imprinting2.06274326
14MP0005174_abnormal_tail_pigmentation2.04791405
15MP0002102_abnormal_ear_morphology2.04338986
16MP0005551_abnormal_eye_electrophysiolog1.96897009
17MP0008057_abnormal_DNA_replication1.93103930
18MP0003786_premature_aging1.84239904
19MP0002938_white_spotting1.79900848
20MP0000569_abnormal_digit_pigmentation1.75788739
21MP0000427_abnormal_hair_cycle1.75015979
22MP0005084_abnormal_gallbladder_morpholo1.66159785
23MP0008875_abnormal_xenobiotic_pharmacok1.65977631
24MP0001968_abnormal_touch/_nociception1.55937250
25MP0005253_abnormal_eye_physiology1.55526305
26MP0002876_abnormal_thyroid_physiology1.48636533
27MP0009046_muscle_twitch1.48575278
28MP0002736_abnormal_nociception_after1.45957571
29MP0006036_abnormal_mitochondrial_physio1.45301695
30MP0004885_abnormal_endolymph1.44545940
31MP0005646_abnormal_pituitary_gland1.44256509
32MP0001293_anophthalmia1.43985695
33MP0008872_abnormal_physiological_respon1.43346140
34MP0002163_abnormal_gland_morphology1.42740273
35MP0005075_abnormal_melanosome_morpholog1.39917201
36MP0008995_early_reproductive_senescence1.38060903
37MP0003111_abnormal_nucleus_morphology1.37882341
38MP0000631_abnormal_neuroendocrine_gland1.37464720
39MP0005379_endocrine/exocrine_gland_phen1.37221885
40MP0006035_abnormal_mitochondrial_morpho1.36303085
41MP0002638_abnormal_pupillary_reflex1.36047816
42MP0002254_reproductive_system_inflammat1.35161724
43MP0003186_abnormal_redox_activity1.34097930
44MP0002160_abnormal_reproductive_system1.32697500
45MP0005389_reproductive_system_phenotype1.32082706
46MP0002095_abnormal_skin_pigmentation1.31970433
47MP0004957_abnormal_blastocyst_morpholog1.29328677
48MP0004133_heterotaxia1.28914118
49MP0001984_abnormal_olfaction1.28336776
50MP0003890_abnormal_embryonic-extraembry1.26236685
51MP0004142_abnormal_muscle_tone1.24930340
52MP0002277_abnormal_respiratory_mucosa1.24715548
53MP0000015_abnormal_ear_pigmentation1.24627693
54MP0001986_abnormal_taste_sensitivity1.24047936
55MP0008007_abnormal_cellular_replicative1.23109391
56MP0001919_abnormal_reproductive_system1.22976401
57MP0003011_delayed_dark_adaptation1.20739212
58MP0002272_abnormal_nervous_system1.20460166
59MP0009745_abnormal_behavioral_response1.20215087
60MP0005645_abnormal_hypothalamus_physiol1.18821007
61MP0001529_abnormal_vocalization1.18550243
62MP0001485_abnormal_pinna_reflex1.17945684
63MP0003646_muscle_fatigue1.16645396
64MP0002210_abnormal_sex_determination1.14462275
65MP0001929_abnormal_gametogenesis1.12006650
66MP0000647_abnormal_sebaceous_gland1.11505602
67MP0003077_abnormal_cell_cycle1.11313708
68MP0004043_abnormal_pH_regulation1.10009241
69MP0003121_genomic_imprinting1.05912265
70MP0002653_abnormal_ependyma_morphology1.05759815
71MP0000383_abnormal_hair_follicle1.04382790
72MP0005332_abnormal_amino_acid1.01798686
73MP0001764_abnormal_homeostasis0.99887157
74MP0009697_abnormal_copulation0.97993966
75MP0002751_abnormal_autonomic_nervous0.97095337
76MP0001501_abnormal_sleep_pattern0.95749231
77MP0005171_absent_coat_pigmentation0.95165742
78MP0002234_abnormal_pharynx_morphology0.94690080
79MP0000653_abnormal_sex_gland0.93115234
80MP0001145_abnormal_male_reproductive0.92675775
81MP0001324_abnormal_eye_pigmentation0.92207186
82MP0003937_abnormal_limbs/digits/tail_de0.92085574
83MP0003283_abnormal_digestive_organ0.90971153
84MP0003806_abnormal_nucleotide_metabolis0.89827280
85MP0008932_abnormal_embryonic_tissue0.88302998
86MP0005408_hypopigmentation0.87542328
87MP0002928_abnormal_bile_duct0.86557010
88MP0003698_abnormal_male_reproductive0.84877183
89MP0003119_abnormal_digestive_system0.84000894
90MP0001486_abnormal_startle_reflex0.83939792
91MP0002090_abnormal_vision0.83761833
92MP0002693_abnormal_pancreas_physiology0.83168396
93MP0000358_abnormal_cell_content/0.81570139
94MP0004742_abnormal_vestibular_system0.80718692
95MP0004215_abnormal_myocardial_fiber0.80119895
96MP0004145_abnormal_muscle_electrophysio0.78747087
97MP0005195_abnormal_posterior_eye0.78574065
98MP0010678_abnormal_skin_adnexa0.78151862
99MP0001944_abnormal_pancreas_morphology0.76108912
100MP0005391_vision/eye_phenotype0.75896406

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.07190622
2Pancreatic fibrosis (HP:0100732)3.77540019
3Molar tooth sign on MRI (HP:0002419)3.57396775
4Abnormality of midbrain morphology (HP:0002418)3.57396775
5Acute necrotizing encephalopathy (HP:0006965)3.28157240
6True hermaphroditism (HP:0010459)3.23492655
7Type II lissencephaly (HP:0007260)3.16606862
8Acute encephalopathy (HP:0006846)3.09333221
9Congenital, generalized hypertrichosis (HP:0004540)3.07181769
10Abnormality of alanine metabolism (HP:0010916)3.06864756
11Hyperalaninemia (HP:0003348)3.06864756
12Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.06864756
13Nephronophthisis (HP:0000090)3.02118846
14Abnormality of the renal cortex (HP:0011035)2.98098170
15Congenital stationary night blindness (HP:0007642)2.96608331
16Progressive macrocephaly (HP:0004481)2.96550309
17Increased CSF lactate (HP:0002490)2.95794476
18Mitochondrial inheritance (HP:0001427)2.88027939
19Abnormal mitochondria in muscle tissue (HP:0008316)2.87662703
20Lipid accumulation in hepatocytes (HP:0006561)2.67481476
21Increased hepatocellular lipid droplets (HP:0006565)2.61745298
22Abnormality of the renal medulla (HP:0100957)2.60576264
23Renal cortical cysts (HP:0000803)2.57032556
24Medial flaring of the eyebrow (HP:0010747)2.52911252
25Birth length less than 3rd percentile (HP:0003561)2.47406386
26Large for gestational age (HP:0001520)2.43280566
27Sclerocornea (HP:0000647)2.39366289
283-Methylglutaconic aciduria (HP:0003535)2.38939037
29Bile duct proliferation (HP:0001408)2.36666494
30Abnormal biliary tract physiology (HP:0012439)2.36666494
31Abnormal number of erythroid precursors (HP:0012131)2.35310656
32Abnormality of the pons (HP:0007361)2.32724488
33Increased serum lactate (HP:0002151)2.32314904
34Furrowed tongue (HP:0000221)2.30358743
35Aplasia/Hypoplasia of the uvula (HP:0010293)2.28984693
36Progressive inability to walk (HP:0002505)2.26897737
37Methylmalonic acidemia (HP:0002912)2.26566670
38Aplasia/hypoplasia of the uterus (HP:0008684)2.26179445
39Pendular nystagmus (HP:0012043)2.25698520
40Hypoplasia of the pons (HP:0012110)2.24868154
41Meckel diverticulum (HP:0002245)2.24411146
42Chronic hepatic failure (HP:0100626)2.23829010
43Abnormality of chromosome stability (HP:0003220)2.21817179
44Abnormality of the ileum (HP:0001549)2.19776080
45Optic disc pallor (HP:0000543)2.18745963
46Tubular atrophy (HP:0000092)2.18179213
47Cystic liver disease (HP:0006706)2.13884306
48Chromosomal breakage induced by crosslinking agents (HP:0003221)2.13701395
49Abnormality of cells of the erythroid lineage (HP:0012130)2.11479886
50Cerebral edema (HP:0002181)2.10006820
51Hepatic necrosis (HP:0002605)2.08659170
52Hepatocellular necrosis (HP:0001404)2.08061810
53Cerebellar dysplasia (HP:0007033)2.07818283
54Ketoacidosis (HP:0001993)2.06670264
55Chromsome breakage (HP:0040012)2.05804156
56Hypothermia (HP:0002045)2.05427479
57Abnormal drinking behavior (HP:0030082)2.04866633
58Polydipsia (HP:0001959)2.04866633
59Methylmalonic aciduria (HP:0012120)2.03359801
60Renal Fanconi syndrome (HP:0001994)2.03345275
61Abolished electroretinogram (ERG) (HP:0000550)2.02995070
62Lactic acidosis (HP:0003128)2.02963378
63Abnormality of the preputium (HP:0100587)2.00753882
64Male pseudohermaphroditism (HP:0000037)2.00595968
65Absent thumb (HP:0009777)2.00402427
66Inability to walk (HP:0002540)1.99613352
67Anencephaly (HP:0002323)1.96648664
68Severe muscular hypotonia (HP:0006829)1.95833957
69Attenuation of retinal blood vessels (HP:0007843)1.94942214
70Concave nail (HP:0001598)1.87013422
71Aplasia/Hypoplasia of the tongue (HP:0010295)1.84026585
72Colon cancer (HP:0003003)1.83612450
73Abnormality of the labia minora (HP:0012880)1.82671988
74Hyperinsulinemic hypoglycemia (HP:0000825)1.81804452
75Hypoplasia of the uterus (HP:0000013)1.81508099
76Congenital hepatic fibrosis (HP:0002612)1.81038643
77Aplasia/Hypoplasia of the fovea (HP:0008060)1.80614150
78Hypoplasia of the fovea (HP:0007750)1.80614150
79Congenital primary aphakia (HP:0007707)1.79311996
80Type I transferrin isoform profile (HP:0003642)1.78750540
81Abnormal protein glycosylation (HP:0012346)1.77337155
82Abnormal glycosylation (HP:0012345)1.77337155
83Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.77337155
84Abnormal protein N-linked glycosylation (HP:0012347)1.77337155
85Lethargy (HP:0001254)1.76624905
86Gait imbalance (HP:0002141)1.75725588
87Sloping forehead (HP:0000340)1.75316741
88Aplasia/Hypoplasia of the tibia (HP:0005772)1.72982634
89Hyperventilation (HP:0002883)1.71757171
90Lissencephaly (HP:0001339)1.69989187
91Patellar aplasia (HP:0006443)1.69028620
92Polyuria (HP:0000103)1.68707339
93Hypoglycemic coma (HP:0001325)1.67635142
94Reticulocytopenia (HP:0001896)1.67066234
95Gaze-evoked nystagmus (HP:0000640)1.66344345
96Dandy-Walker malformation (HP:0001305)1.65406909
97Azoospermia (HP:0000027)1.64567337
98Nephrogenic diabetes insipidus (HP:0009806)1.64547274
99Abnormality of serum amino acid levels (HP:0003112)1.63448732
100Abnormality of homocysteine metabolism (HP:0010919)1.62768539

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.10734538
2ZAK3.23620455
3ADRBK22.89241638
4BMPR1B2.77171531
5TLK12.65717685
6BUB12.47624528
7NUAK12.37790574
8ACVR1B2.36877831
9MAP4K22.25727601
10WNK32.22570523
11INSRR2.21896751
12MST42.02738805
13TRIM282.02534079
14MKNK22.00543336
15TSSK61.97095740
16VRK21.85967215
17WNK41.83595532
18GRK11.79315083
19PINK11.75213510
20WEE11.73194899
21BRSK21.70286910
22CDC71.68917813
23VRK11.64654225
24PLK31.61408333
25SRPK11.56296564
26STK161.54696715
27TNIK1.49107470
28MKNK11.39681188
29PBK1.38965173
30TTK1.30967948
31EIF2AK31.28848458
32TAOK31.18136358
33STK391.14437430
34TAF11.13727825
35MAPK131.13417043
36OXSR11.11011030
37TXK1.09705857
38PLK41.06898281
39NME11.06434960
40ERBB31.04931127
41NEK11.03636261
42PLK11.03544822
43MAP3K41.02832303
44PNCK1.01388111
45EIF2AK10.95708186
46CSNK1G10.93034011
47MAP3K120.92434062
48PHKG20.90472551
49PHKG10.90472551
50CHEK20.90038863
51PAK30.86489269
52NEK20.85131409
53EIF2AK20.84801975
54CCNB10.83478948
55ATR0.83117107
56CASK0.81217251
57RPS6KA50.80977544
58ADRBK10.79421217
59DYRK20.74156510
60IKBKB0.71046994
61TGFBR10.70813994
62CSNK1G30.69911751
63MAP2K20.69370345
64CAMKK20.68689574
65PDK20.68659537
66MAP3K90.67487372
67CSNK1G20.67334566
68PLK20.66621607
69PRKCI0.66013428
70MUSK0.63728566
71IRAK10.61940343
72PRKCE0.60498437
73BCKDK0.60479672
74PRKCG0.60114409
75AURKB0.57826906
76ATM0.54298744
77MAP2K70.52338061
78MAPKAPK30.51695835
79MAPKAPK50.50876365
80FER0.50833658
81STK30.48517056
82PASK0.48309926
83STK38L0.48078768
84TEC0.44424642
85NLK0.44362773
86CSNK2A10.43837964
87CSNK1A1L0.43573477
88FLT30.43504527
89DYRK30.42388187
90MARK30.41426186
91CSNK1E0.40442289
92BRSK10.39992600
93CSNK2A20.39780953
94CHEK10.39699855
95ERBB40.39471490
96CDK30.36251896
97CHUK0.35399718
98LIMK10.33589813
99MAP2K10.32900853
100AURKA0.31657300

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.28590609
2RNA polymerase_Homo sapiens_hsa030202.98444692
3Homologous recombination_Homo sapiens_hsa034402.97481603
4Protein export_Homo sapiens_hsa030602.96569187
5Proteasome_Homo sapiens_hsa030502.71046021
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.64208564
7Parkinsons disease_Homo sapiens_hsa050122.59664745
8Basal transcription factors_Homo sapiens_hsa030222.42538288
9Selenocompound metabolism_Homo sapiens_hsa004502.23550472
10Fanconi anemia pathway_Homo sapiens_hsa034602.08270772
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.06992749
12Non-homologous end-joining_Homo sapiens_hsa034502.01820930
13One carbon pool by folate_Homo sapiens_hsa006702.01195526
14Ribosome_Homo sapiens_hsa030102.00039621
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.99366904
16Mismatch repair_Homo sapiens_hsa034301.95622390
17Maturity onset diabetes of the young_Homo sapiens_hsa049501.94835820
18RNA degradation_Homo sapiens_hsa030181.91791495
19DNA replication_Homo sapiens_hsa030301.89151107
20Huntingtons disease_Homo sapiens_hsa050161.83657854
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.82526131
22Phototransduction_Homo sapiens_hsa047441.74967975
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.71048656
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.66880183
25Nucleotide excision repair_Homo sapiens_hsa034201.66124452
26RNA transport_Homo sapiens_hsa030131.60913246
27Alzheimers disease_Homo sapiens_hsa050101.59228232
28Sulfur metabolism_Homo sapiens_hsa009201.59161763
29Butanoate metabolism_Homo sapiens_hsa006501.56852989
30Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.55707049
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.51517863
32Propanoate metabolism_Homo sapiens_hsa006401.50053662
33Pyrimidine metabolism_Homo sapiens_hsa002401.45735615
34Nitrogen metabolism_Homo sapiens_hsa009101.45156533
35Spliceosome_Homo sapiens_hsa030401.44865908
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.35319201
37Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.34789746
38Tryptophan metabolism_Homo sapiens_hsa003801.34660531
39Linoleic acid metabolism_Homo sapiens_hsa005911.27677926
40Cardiac muscle contraction_Homo sapiens_hsa042601.26946700
41Base excision repair_Homo sapiens_hsa034101.25471074
42Caffeine metabolism_Homo sapiens_hsa002321.23941467
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.22790571
44Purine metabolism_Homo sapiens_hsa002301.20666636
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.13896187
46Folate biosynthesis_Homo sapiens_hsa007901.11379472
47Cysteine and methionine metabolism_Homo sapiens_hsa002701.04905644
48Peroxisome_Homo sapiens_hsa041461.03940846
49Collecting duct acid secretion_Homo sapiens_hsa049660.98905194
50Regulation of autophagy_Homo sapiens_hsa041400.93703711
51Ether lipid metabolism_Homo sapiens_hsa005650.92823928
52Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.92017663
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.88714517
54Pyruvate metabolism_Homo sapiens_hsa006200.88529922
55Nicotine addiction_Homo sapiens_hsa050330.86318234
56Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.84766011
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.82531661
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80198536
59Metabolic pathways_Homo sapiens_hsa011000.77486331
60Chemical carcinogenesis_Homo sapiens_hsa052040.67591460
61Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.67227769
62Vitamin B6 metabolism_Homo sapiens_hsa007500.65253713
63Taste transduction_Homo sapiens_hsa047420.64893765
64Cell cycle_Homo sapiens_hsa041100.63286955
65Olfactory transduction_Homo sapiens_hsa047400.60608120
66Sulfur relay system_Homo sapiens_hsa041220.59332251
67Fatty acid elongation_Homo sapiens_hsa000620.59313267
68Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57709639
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57275243
70Glutathione metabolism_Homo sapiens_hsa004800.57075067
71Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55909280
72Primary bile acid biosynthesis_Homo sapiens_hsa001200.51541983
73Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.47360233
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47009670
75Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43723865
76p53 signaling pathway_Homo sapiens_hsa041150.42965851
77Oocyte meiosis_Homo sapiens_hsa041140.41838658
78Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41748721
79Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.41294615
80Steroid biosynthesis_Homo sapiens_hsa001000.39760838
81Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.39526069
82mRNA surveillance pathway_Homo sapiens_hsa030150.37521558
83Arachidonic acid metabolism_Homo sapiens_hsa005900.36933267
84Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.36385662
85beta-Alanine metabolism_Homo sapiens_hsa004100.36189103
86Morphine addiction_Homo sapiens_hsa050320.34866404
87Intestinal immune network for IgA production_Homo sapiens_hsa046720.33471356
88Insulin secretion_Homo sapiens_hsa049110.32995069
89Fat digestion and absorption_Homo sapiens_hsa049750.32866548
90Steroid hormone biosynthesis_Homo sapiens_hsa001400.32866501
91Retinol metabolism_Homo sapiens_hsa008300.31630654
92ABC transporters_Homo sapiens_hsa020100.30232988
93Circadian rhythm_Homo sapiens_hsa047100.29771039
94Vitamin digestion and absorption_Homo sapiens_hsa049770.28572500
95Systemic lupus erythematosus_Homo sapiens_hsa053220.26215970
96N-Glycan biosynthesis_Homo sapiens_hsa005100.25361170
97Ovarian steroidogenesis_Homo sapiens_hsa049130.25003486
98Serotonergic synapse_Homo sapiens_hsa047260.23061184
99Glycerolipid metabolism_Homo sapiens_hsa005610.21708718
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.20391506

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