ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA damage response, detection of DNA damage (GO:0042769)	4.25473098
2	nonmotile primary cilium assembly (GO:0035058)	4.14462740
3	cellular ketone body metabolic process (GO:0046950)	4.04323121
4	respiratory chain complex IV assembly (GO:0008535)	3.85238117
5	response to pheromone (GO:0019236)	3.76904488
6	protein-cofactor linkage (GO:0018065)	3.69580717
7	ketone body metabolic process (GO:1902224)	3.57270756
8	regulation of cilium movement (GO:0003352)	3.45462805
9	photoreceptor cell maintenance (GO:0045494)	3.40792493
10	cytochrome complex assembly (GO:0017004)	3.35258873
11	regulation of mitochondrial translation (GO:0070129)	3.34545265
12	positive regulation of mitochondrial fission (GO:0090141)	3.28608214
13	gamma-aminobutyric acid transport (GO:0015812)	3.24577562
14	mitochondrial RNA metabolic process (GO:0000959)	3.07643431
15	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.04143190
16	succinate metabolic process (GO:0006105)	3.02913878
17	protein complex biogenesis (GO:0070271)	3.02150763
18	cilium or flagellum-dependent cell motility (GO:0001539)	3.01360989
19	pseudouridine synthesis (GO:0001522)	2.99935497
20	intraciliary transport (GO:0042073)	2.95357221
21	water-soluble vitamin biosynthetic process (GO:0042364)	2.90424212
22	mitochondrial respiratory chain complex assembly (GO:0033108)	2.89359530
23	cilium organization (GO:0044782)	2.86012942
24	cilium assembly (GO:0042384)	2.85234056
25	adenosine metabolic process (GO:0046085)	2.79865790
26	cilium morphogenesis (GO:0060271)	2.79489793
27	behavioral response to nicotine (GO:0035095)	2.73293498
28	epithelial cilium movement (GO:0003351)	2.71432430
29	axoneme assembly (GO:0035082)	2.71292350
30	nucleobase catabolic process (GO:0046113)	2.68929612
31	tRNA methylation (GO:0030488)	2.68254676
32	neuron fate specification (GO:0048665)	2.67888750
33	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.67398034
34	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.66314634
35	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.66314634
36	neural tube formation (GO:0001841)	2.63435515
37	ubiquinone metabolic process (GO:0006743)	2.62449921
38	cullin deneddylation (GO:0010388)	2.60661843
39	regulation of glucokinase activity (GO:0033131)	2.59619302
40	regulation of hexokinase activity (GO:1903299)	2.59619302
41	preassembly of GPI anchor in ER membrane (GO:0016254)	2.55557053
42	C-terminal protein amino acid modification (GO:0018410)	2.54713076
43	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.52856503
44	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.52856503
45	NADH dehydrogenase complex assembly (GO:0010257)	2.52856503
46	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.49975581
47	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.49747119
48	anterograde synaptic vesicle transport (GO:0048490)	2.49305855
49	cilium movement (GO:0003341)	2.48929768
50	axonemal dynein complex assembly (GO:0070286)	2.48897422
51	behavioral response to ethanol (GO:0048149)	2.48853987
52	histone H2A acetylation (GO:0043968)	2.46914774
53	microtubule nucleation (GO:0007020)	2.44434390
54	dicarboxylic acid catabolic process (GO:0043649)	2.43684351
55	neuron cell-cell adhesion (GO:0007158)	2.42952762
56	ubiquinone biosynthetic process (GO:0006744)	2.42826953
57	pyrimidine nucleobase catabolic process (GO:0006208)	2.42193635
58	reflex (GO:0060004)	2.41105567
59	signal peptide processing (GO:0006465)	2.41080653
60	protein polyglutamylation (GO:0018095)	2.40324129
61	DNA ligation (GO:0006266)	2.39535597
62	peptidyl-histidine modification (GO:0018202)	2.38882614
63	DNA double-strand break processing (GO:0000729)	2.38184241
64	ribosome assembly (GO:0042255)	2.36022679
65	retinal cone cell development (GO:0046549)	2.35109878
66	resolution of meiotic recombination intermediates (GO:0000712)	2.33877560
67	protein deneddylation (GO:0000338)	2.33621851
68	detection of calcium ion (GO:0005513)	2.32761481
69	methionine biosynthetic process (GO:0009086)	2.31673599
70	L-methionine salvage (GO:0071267)	2.31331994
71	L-methionine biosynthetic process (GO:0071265)	2.31331994
72	amino acid salvage (GO:0043102)	2.31331994
73	adaptation of signaling pathway (GO:0023058)	2.31240037
74	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.30585434
75	negative regulation of oligodendrocyte differentiation (GO:0048715)	2.28970601
76	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	2.27221480
77	opioid receptor signaling pathway (GO:0038003)	2.26819410
78	neurotransmitter biosynthetic process (GO:0042136)	2.26438082
79	determination of left/right symmetry (GO:0007368)	2.25277852
80	quinone biosynthetic process (GO:1901663)	2.23877775
81	C-terminal protein lipidation (GO:0006501)	2.22334518
82	neuronal action potential (GO:0019228)	2.20840105
83	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	2.20591981
84	spinal cord motor neuron differentiation (GO:0021522)	2.20506962
85	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.19959543
86	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.19959543
87	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.19844649
88	tRNA processing (GO:0008033)	2.19844445
89	neuropeptide signaling pathway (GO:0007218)	2.19819210
90	presynaptic membrane assembly (GO:0097105)	2.19488981
91	proteasome assembly (GO:0043248)	2.19298807
92	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902235	2.18910323
93	inositol phosphate catabolic process (GO:0071545)	2.18865139
94	anterograde axon cargo transport (GO:0008089)	2.18269635
95	ribonucleoprotein complex disassembly (GO:0032988)	2.18234080
96	DNA replication-dependent nucleosome assembly (GO:0006335)	2.17730355
97	DNA replication-dependent nucleosome organization (GO:0034723)	2.17730355
98	regulation of cytokine production involved in inflammatory response (GO:1900015)	2.17691115
99	proline transport (GO:0015824)	2.16921791
100	prenylation (GO:0097354)	2.16410728

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.86875310
2	IGF1R_20145208_ChIP-Seq_DFB_Human	3.25680856
3	FUS_26573619_Chip-Seq_HEK293_Human	3.12496114
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.73753612
5	TAF15_26573619_Chip-Seq_HEK293_Human	2.70812422
6	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.54522284
7	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.51938400
8	EWS_26573619_Chip-Seq_HEK293_Human	2.51375643
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.50392069
10	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.46164552
11	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.45063255
12	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.44058567
13	GBX2_23144817_ChIP-Seq_PC3_Human	2.37668389
14	VDR_22108803_ChIP-Seq_LS180_Human	2.31590481
15	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.24001472
16	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.22627128
17	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.21369893
18	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.21011966
19	E2F7_22180533_ChIP-Seq_HELA_Human	2.18263130
20	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.15090441
21	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.13891862
22	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.02559638
23	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.02327917
24	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.87592121
25	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.87001984
26	P300_19829295_ChIP-Seq_ESCs_Human	1.82662327
27	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.77636274
28	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.74391522
29	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.72157914
30	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.66407554
31	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.62856536
32	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.61938871
33	RNF2_27304074_Chip-Seq_NSC_Mouse	1.58524208
34	ELK1_19687146_ChIP-ChIP_HELA_Human	1.57280973
35	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.56564401
36	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.54499373
37	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.47160844
38	VDR_23849224_ChIP-Seq_CD4+_Human	1.45870082
39	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.44968140
40	MYC_18940864_ChIP-ChIP_HL60_Human	1.43966419
41	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.40163529
42	REST_21632747_ChIP-Seq_MESCs_Mouse	1.40117797
43	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.37968700
44	SMAD4_21799915_ChIP-Seq_A2780_Human	1.36461762
45	ER_23166858_ChIP-Seq_MCF-7_Human	1.33191728
46	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.31739185
47	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.30208915
48	CBP_20019798_ChIP-Seq_JUKART_Human	1.29969209
49	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.29969209
50	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.27643424
51	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.27583418
52	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.27402776
53	STAT3_23295773_ChIP-Seq_U87_Human	1.26310826
54	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.26220264
55	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.26125722
56	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.25889663
57	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.25099631
58	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.24125862
59	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.23552146
60	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.21877409
61	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.18899037
62	TP53_22573176_ChIP-Seq_HFKS_Human	1.16981820
63	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.14716813
64	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.14087828
65	DCP1A_22483619_ChIP-Seq_HELA_Human	1.12150909
66	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.11435473
67	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.10966232
68	FOXP3_21729870_ChIP-Seq_TREG_Human	1.10656045
69	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.09421166
70	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.09125739
71	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.08744744
72	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.08505046
73	TTF2_22483619_ChIP-Seq_HELA_Human	1.07313799
74	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.07279144
75	HTT_18923047_ChIP-ChIP_STHdh_Human	1.06015820
76	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.05360870
77	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.05181615
78	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.05181615
79	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.05180186
80	RUNX2_22187159_ChIP-Seq_PCA_Human	1.05063004
81	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.04595939
82	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.04178647
83	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.03955210
84	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.03835855
85	JUN_21703547_ChIP-Seq_K562_Human	1.02741903
86	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.02621178
87	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.01990721
88	IRF1_19129219_ChIP-ChIP_H3396_Human	1.01133132
89	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.00928773
90	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.00909014
91	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.00742337
92	EZH2_22144423_ChIP-Seq_EOC_Human	1.00136584
93	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.99044405
94	PHF8_20622853_ChIP-Seq_HELA_Human	0.99041275
95	AR_25329375_ChIP-Seq_VCAP_Human	0.97570996
96	AR_21572438_ChIP-Seq_LNCaP_Human	0.97497077
97	TCF4_23295773_ChIP-Seq_U87_Human	0.97463651
98	NCOR_22424771_ChIP-Seq_293T_Human	0.97210402
99	NANOG_19829295_ChIP-Seq_ESCs_Human	0.96886571
100	SOX2_19829295_ChIP-Seq_ESCs_Human	0.96886571

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002102_abnormal_ear_morphology	3.29520766
2	MP0002837_dystrophic_cardiac_calcinosis	2.61229483
3	MP0003136_yellow_coat_color	2.56799095
4	MP0003195_calcinosis	2.52988758
5	MP0005645_abnormal_hypothalamus_physiol	2.51430265
6	MP0008058_abnormal_DNA_repair	2.25185703
7	MP0009046_muscle_twitch	2.22395904
8	MP0002234_abnormal_pharynx_morphology	2.17134385
9	MP0008877_abnormal_DNA_methylation	2.15142238
10	MP0000569_abnormal_digit_pigmentation	2.14623209
11	MP0003283_abnormal_digestive_organ	2.09847232
12	MP0005379_endocrine/exocrine_gland_phen	2.07815867
13	MP0001984_abnormal_olfaction	2.07584994
14	MP0001529_abnormal_vocalization	1.99013794
15	MP0003787_abnormal_imprinting	1.88485111
16	MP0002653_abnormal_ependyma_morphology	1.85918182
17	MP0006072_abnormal_retinal_apoptosis	1.84968007
18	MP0002163_abnormal_gland_morphology	1.84592136
19	MP0003122_maternal_imprinting	1.83970270
20	MP0005551_abnormal_eye_electrophysiolog	1.81556232
21	MP0005646_abnormal_pituitary_gland	1.80020241
22	MP0000631_abnormal_neuroendocrine_gland	1.77988756
23	MP0003121_genomic_imprinting	1.72559583
24	MP0002909_abnormal_adrenal_gland	1.67965807
25	MP0008057_abnormal_DNA_replication	1.67229785
26	MP0002876_abnormal_thyroid_physiology	1.63282312
27	MP0005253_abnormal_eye_physiology	1.62789604
28	MP0006276_abnormal_autonomic_nervous	1.59736491
29	MP0000013_abnormal_adipose_tissue	1.57884276
30	MP0009745_abnormal_behavioral_response	1.54837474
31	MP0008789_abnormal_olfactory_epithelium	1.51512916
32	MP0002272_abnormal_nervous_system	1.48135113
33	MP0001968_abnormal_touch/_nociception	1.43756861
34	MP0002160_abnormal_reproductive_system	1.40039019
35	MP0010094_abnormal_chromosome_stability	1.34751399
36	MP0002572_abnormal_emotion/affect_behav	1.34703871
37	MP0002064_seizures	1.31242423
38	MP0001764_abnormal_homeostasis	1.30244644
39	MP0002928_abnormal_bile_duct	1.28433734
40	MP0004133_heterotaxia	1.26914802
41	MP0001944_abnormal_pancreas_morphology	1.25098880
42	MP0002557_abnormal_social/conspecific_i	1.23066309
43	MP0002638_abnormal_pupillary_reflex	1.22180829
44	MP0008995_early_reproductive_senescence	1.21085885
45	MP0005499_abnormal_olfactory_system	1.19924758
46	MP0005394_taste/olfaction_phenotype	1.19924758
47	MP0001905_abnormal_dopamine_level	1.19422005
48	MP0002736_abnormal_nociception_after	1.19082814
49	MP0003635_abnormal_synaptic_transmissio	1.18839976
50	MP0004885_abnormal_endolymph	1.16331903
51	MP0004270_analgesia	1.13449489
52	MP0000778_abnormal_nervous_system	1.12962878
53	MP0003880_abnormal_central_pattern	1.11710783
54	MP0001270_distended_abdomen	1.11040683
55	MP0001485_abnormal_pinna_reflex	1.10541732
56	MP0002229_neurodegeneration	1.08174668
57	MP0004142_abnormal_muscle_tone	1.05275239
58	MP0001346_abnormal_lacrimal_gland	1.04516309
59	MP0002693_abnormal_pancreas_physiology	1.03517212
60	MP0002063_abnormal_learning/memory/cond	1.00844124
61	MP0000516_abnormal_urinary_system	0.99873177
62	MP0005367_renal/urinary_system_phenotyp	0.99873177
63	MP0003693_abnormal_embryo_hatching	0.98430847
64	MP0002067_abnormal_sensory_capabilities	0.98372861
65	MP0001501_abnormal_sleep_pattern	0.96834806
66	MP0005174_abnormal_tail_pigmentation	0.96790221
67	MP0000955_abnormal_spinal_cord	0.96318914
68	MP0000026_abnormal_inner_ear	0.94021949
69	MP0000427_abnormal_hair_cycle	0.93335063
70	MP0000383_abnormal_hair_follicle	0.92365890
71	MP0002233_abnormal_nose_morphology	0.92157336
72	MP0002734_abnormal_mechanical_nocicepti	0.92065839
73	MP0006036_abnormal_mitochondrial_physio	0.91515033
74	MP0004811_abnormal_neuron_physiology	0.91381496
75	MP0001929_abnormal_gametogenesis	0.91022670
76	MP0003937_abnormal_limbs/digits/tail_de	0.90646754
77	MP0002938_white_spotting	0.90578285
78	MP0000049_abnormal_middle_ear	0.90098277
79	MP0005389_reproductive_system_phenotype	0.89783085
80	MP0004924_abnormal_behavior	0.89701541
81	MP0005386_behavior/neurological_phenoty	0.89701541
82	MP0001970_abnormal_pain_threshold	0.89005811
83	MP0005187_abnormal_penis_morphology	0.88828834
84	MP0006292_abnormal_olfactory_placode	0.88672668
85	MP0003786_premature_aging	0.88002404
86	MP0003698_abnormal_male_reproductive	0.87527694
87	MP0000372_irregular_coat_pigmentation	0.87164602
88	MP0003938_abnormal_ear_development	0.86771899
89	MP0002752_abnormal_somatic_nervous	0.85163328
90	MP0005195_abnormal_posterior_eye	0.85108284
91	MP0001486_abnormal_startle_reflex	0.82232410
92	MP0002882_abnormal_neuron_morphology	0.82046539
93	MP0003633_abnormal_nervous_system	0.81935230
94	MP0001963_abnormal_hearing_physiology	0.80533421
95	MP0002751_abnormal_autonomic_nervous	0.80261088
96	MP0002177_abnormal_outer_ear	0.79782406
97	MP0004742_abnormal_vestibular_system	0.79301501
98	MP0002184_abnormal_innervation	0.78595995
99	MP0002090_abnormal_vision	0.78011138
100	MP0002210_abnormal_sex_determination	0.77039261

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic fibrosis (HP:0100732)	3.86529413
2	Pancreatic cysts (HP:0001737)	3.68969230
3	Medial flaring of the eyebrow (HP:0010747)	3.68503209
4	Abnormality of midbrain morphology (HP:0002418)	3.47743360
5	Molar tooth sign on MRI (HP:0002419)	3.47743360
6	Congenital primary aphakia (HP:0007707)	3.42851775
7	True hermaphroditism (HP:0010459)	3.38866832
8	Gait imbalance (HP:0002141)	3.35046493
9	Intestinal atresia (HP:0011100)	3.25712137
10	Nephronophthisis (HP:0000090)	3.24528641
11	Nephrogenic diabetes insipidus (HP:0009806)	3.02275496
12	Abnormality of the renal cortex (HP:0011035)	2.85088869
13	Sclerocornea (HP:0000647)	2.80579205
14	Abnormality of the renal medulla (HP:0100957)	2.71884198
15	Congenital malformation of the right heart (HP:0011723)	2.61556549
16	Double outlet right ventricle (HP:0001719)	2.61556549
17	Volvulus (HP:0002580)	2.60807336
18	Reduced antithrombin III activity (HP:0001976)	2.60199964
19	Renal cortical cysts (HP:0000803)	2.58906457
20	Bile duct proliferation (HP:0001408)	2.56211212
21	Abnormal biliary tract physiology (HP:0012439)	2.56211212
22	Large for gestational age (HP:0001520)	2.54607239
23	Gastrointestinal atresia (HP:0002589)	2.52653273
24	Hyperinsulinemic hypoglycemia (HP:0000825)	2.50304059
25	Abnormal drinking behavior (HP:0030082)	2.45217737
26	Polydipsia (HP:0001959)	2.45217737
27	Congenital stationary night blindness (HP:0007642)	2.43571497
28	Genital tract atresia (HP:0001827)	2.42093406
29	Retinal dysplasia (HP:0007973)	2.36367959
30	Ketoacidosis (HP:0001993)	2.35892964
31	Vaginal atresia (HP:0000148)	2.34044042
32	Poor coordination (HP:0002370)	2.28123141
33	Cystic liver disease (HP:0006706)	2.27988542
34	Hypoglycemic seizures (HP:0002173)	2.26102575
35	Congenital hepatic fibrosis (HP:0002612)	2.24851989
36	Increased CSF lactate (HP:0002490)	2.24137530
37	Postaxial foot polydactyly (HP:0001830)	2.14299290
38	Hyperventilation (HP:0002883)	2.12916753
39	Anencephaly (HP:0002323)	2.12027753
40	Attenuation of retinal blood vessels (HP:0007843)	2.11992822
41	Occipital encephalocele (HP:0002085)	2.11533411
42	Pancreatic islet-cell hyperplasia (HP:0004510)	2.09503283
43	Acute necrotizing encephalopathy (HP:0006965)	2.08941675
44	Preaxial hand polydactyly (HP:0001177)	2.08754028
45	Postaxial hand polydactyly (HP:0001162)	2.08351801
46	Hypsarrhythmia (HP:0002521)	2.04744042
47	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.02842637
48	Progressive macrocephaly (HP:0004481)	2.02449745
49	Abnormal respiratory epithelium morphology (HP:0012253)	2.02186165
50	Abnormal respiratory motile cilium morphology (HP:0005938)	2.02186165
51	Hypoglycemic coma (HP:0001325)	2.01135514
52	Progressive inability to walk (HP:0002505)	2.00882108
53	Furrowed tongue (HP:0000221)	2.00662677
54	Abnormality of the pancreatic islet cells (HP:0006476)	2.00612038
55	Abnormality of endocrine pancreas physiology (HP:0012093)	2.00612038
56	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.00554492
57	Abnormal protein N-linked glycosylation (HP:0012347)	2.00554492
58	Abnormal protein glycosylation (HP:0012346)	2.00554492
59	Abnormal glycosylation (HP:0012345)	2.00554492
60	EEG with generalized epileptiform discharges (HP:0011198)	1.99650290
61	Absent/shortened dynein arms (HP:0200106)	1.98264627
62	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.98264627
63	Esophageal atresia (HP:0002032)	1.96091925
64	Hemiparesis (HP:0001269)	1.94796788
65	Protruding tongue (HP:0010808)	1.94448894
66	Epileptiform EEG discharges (HP:0011182)	1.94290426
67	Renal Fanconi syndrome (HP:0001994)	1.93808740
68	Mitochondrial inheritance (HP:0001427)	1.93667875
69	Methylmalonic acidemia (HP:0002912)	1.93306685
70	Male pseudohermaphroditism (HP:0000037)	1.92708813
71	Abnormal mitochondria in muscle tissue (HP:0008316)	1.92304304
72	Bony spicule pigmentary retinopathy (HP:0007737)	1.91963565
73	Poor suck (HP:0002033)	1.91881165
74	Progressive microcephaly (HP:0000253)	1.91695358
75	Agitation (HP:0000713)	1.90783441
76	Polyuria (HP:0000103)	1.89892396
77	Hyperglycemia (HP:0003074)	1.88702850
78	Unilateral renal agenesis (HP:0000122)	1.87635068
79	Progressive cerebellar ataxia (HP:0002073)	1.86770273
80	Drooling (HP:0002307)	1.86476642
81	Abolished electroretinogram (ERG) (HP:0000550)	1.86256902
82	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.83312122
83	Prominent nasal bridge (HP:0000426)	1.82802006
84	Hepatoblastoma (HP:0002884)	1.82664012
85	Abnormal ciliary motility (HP:0012262)	1.82109085
86	Aplasia/Hypoplasia of the lens (HP:0008063)	1.81927556
87	Respiratory difficulties (HP:0002880)	1.81295069
88	Decreased testicular size (HP:0008734)	1.80710608
89	Constricted visual fields (HP:0001133)	1.79183578
90	Specific learning disability (HP:0001328)	1.78804036
91	Optic disc pallor (HP:0000543)	1.76870936
92	Gaze-evoked nystagmus (HP:0000640)	1.76822160
93	Intellectual disability, progressive (HP:0006887)	1.76331808
94	Limb dystonia (HP:0002451)	1.75584752
95	Abnormal respiratory motile cilium physiology (HP:0012261)	1.74339391
96	Hypothermia (HP:0002045)	1.73233384
97	Abnormality of vitamin B metabolism (HP:0004340)	1.73203398
98	Tubular atrophy (HP:0000092)	1.72864220
99	Lipid accumulation in hepatocytes (HP:0006561)	1.71937890
100	Narrow forehead (HP:0000341)	1.70438544

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	INSRR	5.47651122
2	LATS1	3.87079070
3	FRK	3.73136482
4	MAP4K2	3.67542015
5	BUB1	2.81100983
6	WNK3	2.52354649
7	CASK	2.44987020
8	NUAK1	2.43220380
9	BCR	2.23909213
10	PNCK	2.13844570
11	MAP3K4	1.99043709
12	EIF2AK3	1.97310247
13	ADRBK2	1.93504102
14	CSNK1G3	1.71435898
15	TRIM28	1.65033886
16	GRK1	1.63144352
17	CSNK1G1	1.51759752
18	CSNK1G2	1.50552259
19	CSNK1A1L	1.48722664
20	MARK1	1.43589036
21	ERBB3	1.42598290
22	STK38L	1.35465534
23	NTRK3	1.34712169
24	WEE1	1.34455183
25	CAMKK2	1.30430260
26	NME1	1.30233794
27	PHKG2	1.26320955
28	PHKG1	1.26320955
29	MAP2K7	1.25222166
30	BRSK2	1.21978447
31	DAPK2	1.19952039
32	SRPK1	1.18681021
33	BMPR1B	1.17907526
34	FGFR2	1.16270775
35	TSSK6	1.15136561
36	PINK1	1.14098737
37	MAPK13	1.12231149
38	CCNB1	1.09431729
39	IRAK1	1.05083180
40	PRKCG	1.04541988
41	PLK3	1.03717660
42	CHEK2	1.03258464
43	PASK	1.00342610
44	WNK4	0.98674605
45	NEK1	0.96953549
46	PRKCE	0.91657039
47	ZAK	0.89647447
48	STK3	0.88958009
49	VRK1	0.86503648
50	UHMK1	0.79548121
51	PLK1	0.77710834
52	STK39	0.77049230
53	PLK2	0.75098824
54	CDK3	0.74929152
55	MKNK2	0.73183440
56	IRAK2	0.71497177
57	BRSK1	0.71269690
58	NTRK2	0.70870945
59	STK16	0.70819944
60	DYRK2	0.69876875
61	PLK4	0.69695073
62	CDC7	0.69312972
63	MAPK15	0.68522968
64	PRKD3	0.67595426
65	PAK3	0.66242853
66	MKNK1	0.62520549
67	ATM	0.57573244
68	ATR	0.56547704
69	CSNK1A1	0.53364605
70	EIF2AK1	0.51658657
71	OXSR1	0.50305129
72	CAMK2A	0.49786792
73	DYRK1A	0.48128316
74	PBK	0.47750949
75	PRKACB	0.46281577
76	TTK	0.45418504
77	RPS6KA4	0.45011698
78	AURKA	0.41339320
79	CAMK2D	0.41137324
80	CHEK1	0.41083814
81	EIF2AK2	0.40893225
82	BCKDK	0.39789067
83	MINK1	0.39662559
84	ACVR1B	0.39251979
85	FLT3	0.38174573
86	RPS6KA5	0.37176912
87	LIMK1	0.35975484
88	CSNK1D	0.35761535
89	CSNK1E	0.35331195
90	TAOK1	0.33855561
91	PRKCZ	0.33824593
92	PRKACA	0.33780228
93	TNIK	0.33568478
94	PTK2B	0.32535802
95	CSNK2A2	0.31661512
96	ADRBK1	0.29600945
97	PRKG1	0.28663212
98	CDK1	0.28488798
99	MAP3K7	0.28482892
100	PRKDC	0.28450011

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	3.30887781
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.19965702
3	Butanoate metabolism_Homo sapiens_hsa00650	3.19827590
4	Maturity onset diabetes of the young_Homo sapiens_hsa04950	3.19662079
5	Protein export_Homo sapiens_hsa03060	2.39001778
6	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.29045793
7	Oxidative phosphorylation_Homo sapiens_hsa00190	2.15776088
8	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.10471021
9	Nicotine addiction_Homo sapiens_hsa05033	1.99859977
10	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.95428425
11	RNA polymerase_Homo sapiens_hsa03020	1.93675121
12	Phototransduction_Homo sapiens_hsa04744	1.88353038
13	Homologous recombination_Homo sapiens_hsa03440	1.81978119
14	Fanconi anemia pathway_Homo sapiens_hsa03460	1.75640787
15	Taste transduction_Homo sapiens_hsa04742	1.70092510
16	Folate biosynthesis_Homo sapiens_hsa00790	1.66322533
17	Selenocompound metabolism_Homo sapiens_hsa00450	1.61308343
18	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.61196462
19	Parkinsons disease_Homo sapiens_hsa05012	1.57704059
20	Non-homologous end-joining_Homo sapiens_hsa03450	1.57345315
21	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.46262482
22	Collecting duct acid secretion_Homo sapiens_hsa04966	1.44180669
23	Ether lipid metabolism_Homo sapiens_hsa00565	1.42079027
24	Mismatch repair_Homo sapiens_hsa03430	1.40708866
25	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.38644263
26	One carbon pool by folate_Homo sapiens_hsa00670	1.38256200
27	Propanoate metabolism_Homo sapiens_hsa00640	1.33258407
28	beta-Alanine metabolism_Homo sapiens_hsa00410	1.29661125
29	Insulin secretion_Homo sapiens_hsa04911	1.28034169
30	Basal transcription factors_Homo sapiens_hsa03022	1.24442300
31	GABAergic synapse_Homo sapiens_hsa04727	1.24129331
32	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.23409293
33	Linoleic acid metabolism_Homo sapiens_hsa00591	1.22469594
34	Purine metabolism_Homo sapiens_hsa00230	1.22408866
35	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.20691579
36	Tryptophan metabolism_Homo sapiens_hsa00380	1.20508998
37	Huntingtons disease_Homo sapiens_hsa05016	1.15996474
38	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.12930714
39	Nucleotide excision repair_Homo sapiens_hsa03420	1.11718366
40	DNA replication_Homo sapiens_hsa03030	1.10926774
41	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.10573020
42	Fatty acid elongation_Homo sapiens_hsa00062	1.06563628
43	Spliceosome_Homo sapiens_hsa03040	1.06511957
44	Proteasome_Homo sapiens_hsa03050	1.06040742
45	Circadian rhythm_Homo sapiens_hsa04710	1.05495849
46	Olfactory transduction_Homo sapiens_hsa04740	1.04395064
47	RNA degradation_Homo sapiens_hsa03018	1.03652626
48	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.01899056
49	Morphine addiction_Homo sapiens_hsa05032	1.01858239
50	Pyrimidine metabolism_Homo sapiens_hsa00240	1.01362380
51	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.01350219
52	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.00848559
53	Alzheimers disease_Homo sapiens_hsa05010	0.99578406
54	RNA transport_Homo sapiens_hsa03013	0.99424991
55	Peroxisome_Homo sapiens_hsa04146	0.98539544
56	Regulation of autophagy_Homo sapiens_hsa04140	0.92301313
57	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.92260105
58	Base excision repair_Homo sapiens_hsa03410	0.90796062
59	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.89253682
60	Circadian entrainment_Homo sapiens_hsa04713	0.87917479
61	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.86643741
62	Amphetamine addiction_Homo sapiens_hsa05031	0.85583305
63	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.84348255
64	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.81291535
65	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.80328014
66	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.77408590
67	Cell cycle_Homo sapiens_hsa04110	0.76448190
68	Metabolic pathways_Homo sapiens_hsa01100	0.75836655
69	Cocaine addiction_Homo sapiens_hsa05030	0.74937947
70	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.74210113
71	Oocyte meiosis_Homo sapiens_hsa04114	0.72227543
72	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.69240627
73	Glutamatergic synapse_Homo sapiens_hsa04724	0.67554410
74	Serotonergic synapse_Homo sapiens_hsa04726	0.66659869
75	Cardiac muscle contraction_Homo sapiens_hsa04260	0.62949370
76	Dopaminergic synapse_Homo sapiens_hsa04728	0.61621171
77	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.60759274
78	Nitrogen metabolism_Homo sapiens_hsa00910	0.60165433
79	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.59798729
80	Sulfur metabolism_Homo sapiens_hsa00920	0.59444945
81	Steroid biosynthesis_Homo sapiens_hsa00100	0.59326349
82	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.55337894
83	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.53685255
84	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.52396943
85	Fatty acid metabolism_Homo sapiens_hsa01212	0.51593069
86	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.50434465
87	Glutathione metabolism_Homo sapiens_hsa00480	0.50263205
88	Renin secretion_Homo sapiens_hsa04924	0.49502549
89	Sphingolipid metabolism_Homo sapiens_hsa00600	0.49462572
90	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.44533156
91	ABC transporters_Homo sapiens_hsa02010	0.44031918
92	Vibrio cholerae infection_Homo sapiens_hsa05110	0.43395372
93	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.43352771
94	Fatty acid degradation_Homo sapiens_hsa00071	0.43202168
95	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.42994838
96	Pyruvate metabolism_Homo sapiens_hsa00620	0.42010099
97	Ribosome_Homo sapiens_hsa03010	0.41584847
98	Caffeine metabolism_Homo sapiens_hsa00232	0.41370519
99	Chemical carcinogenesis_Homo sapiens_hsa05204	0.41094596
100	Sulfur relay system_Homo sapiens_hsa04122	0.40605383

CXORF57

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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