ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of meiosis I (GO:0060631)	9.17028351
2	piRNA metabolic process (GO:0034587)	8.73935791
3	male meiosis I (GO:0007141)	8.67375260
4	chromosome organization involved in meiosis (GO:0070192)	8.20926116
5	male meiosis (GO:0007140)	7.49200256
6	meiosis I (GO:0007127)	7.33708420
7	synaptonemal complex assembly (GO:0007130)	6.85018306
8	DNA methylation involved in gamete generation (GO:0043046)	6.51044805
9	meiotic nuclear division (GO:0007126)	6.24526575
10	positive regulation of meiosis (GO:0045836)	6.18419305
11	synaptonemal complex organization (GO:0070193)	6.15490398
12	DNA synthesis involved in DNA repair (GO:0000731)	5.86912363
13	positive regulation of meiotic cell cycle (GO:0051446)	5.76134980
14	negative regulation of meiosis (GO:0045835)	5.51486123
15	sister chromatid cohesion (GO:0007062)	5.43822038
16	reciprocal meiotic recombination (GO:0007131)	4.90893526
17	reciprocal DNA recombination (GO:0035825)	4.90893526
18	meiotic cell cycle process (GO:1903046)	4.86049825
19	regulation of male gonad development (GO:2000018)	4.76926533
20	histone H2A acetylation (GO:0043968)	4.54346045
21	mitotic sister chromatid cohesion (GO:0007064)	4.41173409
22	positive regulation of male gonad development (GO:2000020)	4.28192638
23	resolution of meiotic recombination intermediates (GO:0000712)	4.23477180
24	regulation of meiotic cell cycle (GO:0051445)	3.84053609
25	oocyte development (GO:0048599)	3.81969607
26	artery smooth muscle contraction (GO:0014824)	3.78327169
27	male sex determination (GO:0030238)	3.77494447
28	germ cell migration (GO:0008354)	3.72110767
29	female gamete generation (GO:0007292)	3.71540710
30	negative regulation of meiotic cell cycle (GO:0051447)	3.71107174
31	kinetochore organization (GO:0051383)	3.70463359
32	metaphase plate congression (GO:0051310)	3.61589241
33	regulation of meiosis (GO:0040020)	3.57881232
34	proteasome assembly (GO:0043248)	3.56503122
35	histone exchange (GO:0043486)	3.44170412
36	sex differentiation (GO:0007548)	3.41270435
37	kinetochore assembly (GO:0051382)	3.39598024
38	cullin deneddylation (GO:0010388)	3.37497215
39	inositol phosphate catabolic process (GO:0071545)	3.33743632
40	oogenesis (GO:0048477)	3.29255223
41	CENP-A containing nucleosome assembly (GO:0034080)	3.28944100
42	Sertoli cell development (GO:0060009)	3.28277977
43	phosphorylated carbohydrate dephosphorylation (GO:0046838)	3.11818704
44	inositol phosphate dephosphorylation (GO:0046855)	3.11818704
45	chromatin remodeling at centromere (GO:0031055)	3.10734679
46	intraciliary transport (GO:0042073)	3.09244830
47	protein deneddylation (GO:0000338)	3.04775306
48	tonic smooth muscle contraction (GO:0014820)	3.00987240
49	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.98224917
50	microtubule severing (GO:0051013)	2.96100821
51	protein maturation by protein folding (GO:0022417)	2.94690983
52	regulation of cilium movement (GO:0003352)	2.91457285
53	vascular smooth muscle contraction (GO:0014829)	2.89241759
54	gene silencing by RNA (GO:0031047)	2.88646795
55	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.87753717
56	mitochondrial respiratory chain complex assembly (GO:0033108)	2.83475638
57	base-excision repair, AP site formation (GO:0006285)	2.80038655
58	respiratory chain complex IV assembly (GO:0008535)	2.78814820
59	histone H3-K9 demethylation (GO:0033169)	2.70053081
60	protein complex biogenesis (GO:0070271)	2.69677174
61	endocrine pancreas development (GO:0031018)	2.69509289
62	regulation of microtubule-based movement (GO:0060632)	2.67419369
63	regulation of DNA endoreduplication (GO:0032875)	2.65844624
64	positive regulation of prostaglandin secretion (GO:0032308)	2.64962423
65	cornea development in camera-type eye (GO:0061303)	2.64604302
66	ubiquinone biosynthetic process (GO:0006744)	2.63571174
67	regulation of sister chromatid cohesion (GO:0007063)	2.62057519
68	protein localization to chromosome (GO:0034502)	2.60307110
69	attachment of spindle microtubules to kinetochore (GO:0008608)	2.57322645
70	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.57081800
71	germ cell development (GO:0007281)	2.56951559
72	C-terminal protein lipidation (GO:0006501)	2.55721488
73	DNA catabolic process, exonucleolytic (GO:0000738)	2.54810814
74	axoneme assembly (GO:0035082)	2.53898165
75	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.51162257
76	somite rostral/caudal axis specification (GO:0032525)	2.51147273
77	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.50470636
78	establishment of chromosome localization (GO:0051303)	2.50078426
79	DNA ligation (GO:0006266)	2.45739184
80	preassembly of GPI anchor in ER membrane (GO:0016254)	2.42576185
81	response to redox state (GO:0051775)	2.41552862
82	iron-sulfur cluster assembly (GO:0016226)	2.40822967
83	metallo-sulfur cluster assembly (GO:0031163)	2.40822967
84	regulation of mitochondrial translation (GO:0070129)	2.39630362
85	DNA biosynthetic process (GO:0071897)	2.38023807
86	meiotic chromosome segregation (GO:0045132)	2.36895862
87	negative regulation of nuclear division (GO:0051784)	2.36158945
88	lactate metabolic process (GO:0006089)	2.36130514
89	protein-cofactor linkage (GO:0018065)	2.36129627
90	intracellular protein transmembrane import (GO:0044743)	2.35825738
91	C-terminal protein amino acid modification (GO:0018410)	2.35667636
92	ubiquinone metabolic process (GO:0006743)	2.34249751
93	adenosine metabolic process (GO:0046085)	2.33809392
94	single strand break repair (GO:0000012)	2.33723668
95	mitotic metaphase plate congression (GO:0007080)	2.32911766
96	sex determination (GO:0007530)	2.32823621
97	nucleotide transmembrane transport (GO:1901679)	2.32727010
98	mitotic spindle assembly checkpoint (GO:0007094)	2.32015226
99	chaperone-mediated protein transport (GO:0072321)	2.31861006
100	synapsis (GO:0007129)	10.6497633

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.13155104
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.56434656
3	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.08664172
4	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	3.05187020
5	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	3.02110800
6	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.99854180
7	VDR_22108803_ChIP-Seq_LS180_Human	2.69217763
8	ZNF274_21170338_ChIP-Seq_K562_Hela	2.66748650
9	IGF1R_20145208_ChIP-Seq_DFB_Human	2.64164391
10	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.37938302
11	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.33664298
12	RNF2_27304074_Chip-Seq_NSC_Mouse	2.22981393
13	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.19720901
14	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.18349918
15	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.17667027
16	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.13600968
17	* VDR_23849224_ChIP-Seq_CD4+_Human	2.09709298
18	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.09150947
19	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.03427680
20	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.95410433
21	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.93264064
22	ELK1_19687146_ChIP-ChIP_HELA_Human	1.90685345
23	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.85504377
24	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.83976845
25	EWS_26573619_Chip-Seq_HEK293_Human	1.82917883
26	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.82827393
27	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.82615422
28	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.69684929
29	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.67895033
30	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.66934359
31	FUS_26573619_Chip-Seq_HEK293_Human	1.63989243
32	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.60247351
33	MYC_18940864_ChIP-ChIP_HL60_Human	1.57432710
34	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.54569994
35	* TP53_22573176_ChIP-Seq_HFKS_Human	1.52225531
36	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.52131770
37	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.52024060
38	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.49343789
39	P300_19829295_ChIP-Seq_ESCs_Human	1.48096937
40	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.46009556
41	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.40401092
42	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.36331697
43	FOXP3_21729870_ChIP-Seq_TREG_Human	1.36307331
44	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.34956977
45	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.34956977
46	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.34104305
47	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.28749069
48	DCP1A_22483619_ChIP-Seq_HELA_Human	1.28574737
49	AR_25329375_ChIP-Seq_VCAP_Human	1.27240727
50	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.26918951
51	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.26627842
52	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.25894844
53	HTT_18923047_ChIP-ChIP_STHdh_Human	1.25234458
54	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.25063189
55	TAF15_26573619_Chip-Seq_HEK293_Human	1.24886211
56	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.22979969
57	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.20967278
58	* FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.19435238
59	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.19141401
60	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.18990869
61	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.18906105
62	ER_23166858_ChIP-Seq_MCF-7_Human	1.17209468
63	TTF2_22483619_ChIP-Seq_HELA_Human	1.15938646
64	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.14342303
65	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.12548004
66	GABP_19822575_ChIP-Seq_HepG2_Human	1.11475084
67	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.10709451
68	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.10064646
69	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.07842810
70	* AR_20517297_ChIP-Seq_VCAP_Human	1.06998714
71	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.04742775
72	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.04627620
73	SMAD4_21799915_ChIP-Seq_A2780_Human	1.03120734
74	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.02350363
75	CBP_20019798_ChIP-Seq_JUKART_Human	1.02350363
76	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.02336812
77	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.02136967
78	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.01388321
79	RUNX2_22187159_ChIP-Seq_PCA_Human	1.01223511
80	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.00609014
81	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.99514224
82	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.99095205
83	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.97721228
84	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.96303859
85	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	0.96246842
86	BCAT_22108803_ChIP-Seq_LS180_Human	0.95329964
87	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.94718554
88	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.93771652
89	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.93617351
90	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.91943280
91	GBX2_23144817_ChIP-Seq_PC3_Human	0.91528858
92	NANOG_19829295_ChIP-Seq_ESCs_Human	0.90955049
93	SOX2_19829295_ChIP-Seq_ESCs_Human	0.90955049
94	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.90753209
95	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.90453798
96	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.87726423
97	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.87625701
98	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.87161557
99	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	0.86957704
100	MYC_19829295_ChIP-Seq_ESCs_Human	0.86745696

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	6.50232979
2	MP0008058_abnormal_DNA_repair	4.09947428
3	MP0002210_abnormal_sex_determination	2.99318475
4	MP0005645_abnormal_hypothalamus_physiol	2.94439752
5	MP0002160_abnormal_reproductive_system	2.74611072
6	MP0008995_early_reproductive_senescence	2.63830480
7	MP0001929_abnormal_gametogenesis	2.57729731
8	MP0001145_abnormal_male_reproductive	2.39286722
9	MP0000653_abnormal_sex_gland	2.33335173
10	MP0005389_reproductive_system_phenotype	2.18830162
11	MP0003011_delayed_dark_adaptation	2.14778275
12	MP0003698_abnormal_male_reproductive	2.05605695
13	MP0002102_abnormal_ear_morphology	1.95723765
14	MP0006072_abnormal_retinal_apoptosis	1.94030736
15	MP0003718_maternal_effect	1.87118882
16	MP0002837_dystrophic_cardiac_calcinosis	1.87106361
17	MP0008789_abnormal_olfactory_epithelium	1.82816129
18	MP0006276_abnormal_autonomic_nervous	1.81910649
19	MP0000569_abnormal_digit_pigmentation	1.74023738
20	MP0002163_abnormal_gland_morphology	1.71437156
21	MP0003786_premature_aging	1.69430476
22	MP0001502_abnormal_circadian_rhythm	1.67218429
23	MP0001984_abnormal_olfaction	1.64670987
24	MP0006036_abnormal_mitochondrial_physio	1.64326830
25	MP0000013_abnormal_adipose_tissue	1.63962664
26	MP0000647_abnormal_sebaceous_gland	1.59717646
27	MP0005253_abnormal_eye_physiology	1.59437360
28	MP0001119_abnormal_female_reproductive	1.55694902
29	MP0001661_extended_life_span	1.53631403
30	MP0002638_abnormal_pupillary_reflex	1.52026023
31	MP0005379_endocrine/exocrine_gland_phen	1.51847092
32	MP0006292_abnormal_olfactory_placode	1.49354543
33	MP0006035_abnormal_mitochondrial_morpho	1.46972648
34	MP0000383_abnormal_hair_follicle	1.45952797
35	MP0003123_paternal_imprinting	1.37808742
36	MP0005075_abnormal_melanosome_morpholog	1.37390928
37	MP0000427_abnormal_hair_cycle	1.33290465
38	MP0003121_genomic_imprinting	1.31867847
39	MP0001944_abnormal_pancreas_morphology	1.31140584
40	MP0000631_abnormal_neuroendocrine_gland	1.30003820
41	MP0001919_abnormal_reproductive_system	1.26269622
42	MP0002693_abnormal_pancreas_physiology	1.25614318
43	MP0005551_abnormal_eye_electrophysiolog	1.24571010
44	MP0005646_abnormal_pituitary_gland	1.22591933
45	MP0005410_abnormal_fertilization	1.21171912
46	MP0002751_abnormal_autonomic_nervous	1.21013663
47	MP0000015_abnormal_ear_pigmentation	1.20971312
48	MP0003283_abnormal_digestive_organ	1.20026607
49	MP0008057_abnormal_DNA_replication	1.19958180
50	MP0004043_abnormal_pH_regulation	1.18087782
51	MP0003195_calcinosis	1.17945480
52	MP0000358_abnormal_cell_content/	1.17253409
53	MP0002909_abnormal_adrenal_gland	1.16283363
54	MP0002161_abnormal_fertility/fecundity	1.16091171
55	MP0010678_abnormal_skin_adnexa	1.13679358
56	MP0004215_abnormal_myocardial_fiber	1.10723649
57	MP0005187_abnormal_penis_morphology	1.10596718
58	MP0009046_muscle_twitch	1.10538930
59	MP0003122_maternal_imprinting	1.06707386
60	MP0000372_irregular_coat_pigmentation	1.05618583
61	MP0001764_abnormal_homeostasis	1.04197291
62	MP0001986_abnormal_taste_sensitivity	1.01893237
63	MP0005499_abnormal_olfactory_system	1.01114963
64	MP0005394_taste/olfaction_phenotype	1.01114963
65	MP0008872_abnormal_physiological_respon	0.98997086
66	MP0003699_abnormal_female_reproductive	0.98744298
67	MP0005367_renal/urinary_system_phenotyp	0.98667733
68	MP0000516_abnormal_urinary_system	0.98667733
69	MP0002876_abnormal_thyroid_physiology	0.97556719
70	MP0005084_abnormal_gallbladder_morpholo	0.97302291
71	MP0005332_abnormal_amino_acid	0.96786102
72	MP0010094_abnormal_chromosome_stability	0.96766794
73	MP0003693_abnormal_embryo_hatching	0.96528432
74	MP0005174_abnormal_tail_pigmentation	0.96019400
75	MP0009745_abnormal_behavioral_response	0.94371568
76	MP0000639_abnormal_adrenal_gland	0.90600690
77	MP0002653_abnormal_ependyma_morphology	0.88335738
78	MP0010386_abnormal_urinary_bladder	0.87040474
79	MP0004133_heterotaxia	0.86841527
80	MP0002127_abnormal_cardiovascular_syste	0.85841358
81	MP0004019_abnormal_vitamin_homeostasis	0.85755244
82	MP0003880_abnormal_central_pattern	0.84420393
83	MP0005220_abnormal_exocrine_pancreas	0.83725349
84	MP0001905_abnormal_dopamine_level	0.83410360
85	MP0001501_abnormal_sleep_pattern	0.82016024
86	MP0002229_neurodegeneration	0.81313017
87	MP0003186_abnormal_redox_activity	0.81076872
88	MP0002277_abnormal_respiratory_mucosa	0.80511337
89	MP0003936_abnormal_reproductive_system	0.80510316
90	MP0002735_abnormal_chemical_nociception	0.79656588
91	MP0005636_abnormal_mineral_homeostasis	0.78468274
92	MP0002272_abnormal_nervous_system	0.78375555
93	MP0002822_catalepsy	0.78226218
94	MP0002095_abnormal_skin_pigmentation	0.77675148
95	MP0002928_abnormal_bile_duct	0.77498917
96	MP0008875_abnormal_xenobiotic_pharmacok	0.77354597
97	MP0002736_abnormal_nociception_after	0.76412835
98	MP0001529_abnormal_vocalization	0.74744204
99	MP0002938_white_spotting	0.74100643
100	MP0005535_abnormal_body_temperature	0.72808793

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Degeneration of the lateral corticospinal tracts (HP:0002314)	4.77870687
2	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	4.77870687
3	Nephronophthisis (HP:0000090)	3.64687670
4	Oligodactyly (hands) (HP:0001180)	3.42482238
5	Gonadotropin excess (HP:0000837)	3.34192803
6	Abnormality of the corticospinal tract (HP:0002492)	3.33335567
7	Volvulus (HP:0002580)	3.28582415
8	Supernumerary spleens (HP:0009799)	3.24703840
9	Tubulointerstitial nephritis (HP:0001970)	3.12680099
10	Intestinal atresia (HP:0011100)	2.96122258
11	Acute necrotizing encephalopathy (HP:0006965)	2.86304480
12	Abnormality of the renal medulla (HP:0100957)	2.84479204
13	Pancreatic fibrosis (HP:0100732)	2.83486217
14	Rimmed vacuoles (HP:0003805)	2.78045071
15	Mitochondrial inheritance (HP:0001427)	2.75762605
16	True hermaphroditism (HP:0010459)	2.73163738
17	Male pseudohermaphroditism (HP:0000037)	2.72958796
18	Increased hepatocellular lipid droplets (HP:0006565)	2.72711481
19	Atrophy/Degeneration involving motor neurons (HP:0007373)	2.72468672
20	Renal Fanconi syndrome (HP:0001994)	2.71043020
21	Amyotrophic lateral sclerosis (HP:0007354)	2.70882868
22	Azoospermia (HP:0000027)	2.69440148
23	Osteomalacia (HP:0002749)	2.62868194
24	Impaired vibration sensation in the lower limbs (HP:0002166)	2.62239108
25	Postaxial foot polydactyly (HP:0001830)	2.60082137
26	Progressive macrocephaly (HP:0004481)	2.59973612
27	Medial flaring of the eyebrow (HP:0010747)	2.59838643
28	Increased CSF lactate (HP:0002490)	2.59549572
29	Abnormality of the lower motor neuron (HP:0002366)	2.57004365
30	Delayed CNS myelination (HP:0002188)	2.56961699
31	Pancreatic cysts (HP:0001737)	2.56713439
32	Hypothermia (HP:0002045)	2.56379609
33	Abnormality of the labia minora (HP:0012880)	2.55760740
34	Shoulder girdle muscle weakness (HP:0003547)	2.52227943
35	Hyperinsulinemic hypoglycemia (HP:0000825)	2.44015378
36	Ketoacidosis (HP:0001993)	2.43600610
37	Abnormal mitochondria in muscle tissue (HP:0008316)	2.42338923
38	Oligodactyly (HP:0012165)	2.41496898
39	Hepatic necrosis (HP:0002605)	2.39922890
40	Acute encephalopathy (HP:0006846)	2.39177938
41	Lipid accumulation in hepatocytes (HP:0006561)	2.36261746
42	Abnormal spermatogenesis (HP:0008669)	2.35387938
43	Glycosuria (HP:0003076)	2.29819836
44	Abnormality of urine glucose concentration (HP:0011016)	2.29819836
45	Abnormality of the vocal cords (HP:0008777)	2.29798337
46	Abnormality of renal resorption (HP:0011038)	2.26245551
47	Aplasia/hypoplasia of the uterus (HP:0008684)	2.25500284
48	Hepatocellular necrosis (HP:0001404)	2.23985677
49	Degeneration of anterior horn cells (HP:0002398)	2.23113431
50	Abnormality of the anterior horn cell (HP:0006802)	2.23113431
51	Hypoglycemic coma (HP:0001325)	2.19933825
52	Hypoplasia of the uterus (HP:0000013)	2.19867324
53	Gout (HP:0001997)	2.17706805
54	Neonatal short-limb short stature (HP:0008921)	2.14899583
55	Hyperglycemia (HP:0003074)	2.13225048
56	Nephrogenic diabetes insipidus (HP:0009806)	2.11632286
57	Cerebral edema (HP:0002181)	2.11604433
58	Gait imbalance (HP:0002141)	2.11112574
59	Occipital encephalocele (HP:0002085)	2.10221831
60	Tubular atrophy (HP:0000092)	2.09644340
61	Abnormality of midbrain morphology (HP:0002418)	2.07145973
62	Molar tooth sign on MRI (HP:0002419)	2.07145973
63	Congenital primary aphakia (HP:0007707)	2.06497849
64	Hyperphosphaturia (HP:0003109)	2.04484879
65	Abnormality of the renal cortex (HP:0011035)	2.04377035
66	Retinal dysplasia (HP:0007973)	2.03203958
67	Ketosis (HP:0001946)	2.01980776
68	Hypomagnesemia (HP:0002917)	2.00272560
69	Abnormal lung lobation (HP:0002101)	1.97790548
70	Proximal tubulopathy (HP:0000114)	1.96410932
71	Abnormality of the fovea (HP:0000493)	1.89803464
72	Facial cleft (HP:0002006)	1.89703908
73	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.89270411
74	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.87294487
75	Central scotoma (HP:0000603)	1.86008289
76	Polyphagia (HP:0002591)	1.85663583
77	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.85349790
78	Hand muscle atrophy (HP:0009130)	1.83131648
79	Insulin-resistant diabetes mellitus (HP:0000831)	1.83110736
80	Abnormal hair whorl (HP:0010721)	1.83002991
81	Chronic hepatic failure (HP:0100626)	1.80894513
82	Nausea (HP:0002018)	1.78685761
83	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.78174008
84	Spontaneous abortion (HP:0005268)	1.77146981
85	Tongue fasciculations (HP:0001308)	1.75752284
86	Rhinitis (HP:0012384)	1.73990920
87	Abnormal respiratory motile cilium morphology (HP:0005938)	1.72998593
88	Abnormal respiratory epithelium morphology (HP:0012253)	1.72998593
89	Natal tooth (HP:0000695)	1.72912245
90	Impaired vibratory sensation (HP:0002495)	1.71806988
91	Respiratory failure (HP:0002878)	1.71347719
92	Enlarged penis (HP:0000040)	1.70344427
93	Abnormality of vitamin B metabolism (HP:0004340)	1.69706990
94	Anencephaly (HP:0002323)	1.69436693
95	Agitation (HP:0000713)	1.69277241
96	Stage 5 chronic kidney disease (HP:0003774)	1.69228570
97	Postaxial hand polydactyly (HP:0001162)	1.69095647
98	Congenital, generalized hypertrichosis (HP:0004540)	1.67749565
99	Abnormality of macular pigmentation (HP:0008002)	1.67282507
100	Abnormal ciliary motility (HP:0012262)	1.66162574

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PNCK	4.53161346
2	MAP4K2	3.68849516
3	BMPR1B	3.52312496
4	MST4	3.27570710
5	FRK	3.22118138
6	ACVR1B	3.21248773
7	PDK2	2.76694920
8	NUAK1	2.63491943
9	BCKDK	2.32422670
10	STK16	2.29772175
11	CDK19	2.25780845
12	PLK4	2.19011649
13	PASK	2.06232043
14	BUB1	2.03102655
15	TLK1	1.87791824
16	PHKG2	1.73290106
17	PHKG1	1.73290106
18	MAPK13	1.63565983
19	LIMK1	1.61519609
20	WEE1	1.60961890
21	TRIM28	1.56657416
22	STK38L	1.47061024
23	OXSR1	1.40795818
24	GRK1	1.30386701
25	PLK1	1.28590258
26	BCR	1.27737367
27	ZAK	1.24691835
28	DYRK2	1.20749817
29	VRK1	1.17715185
30	WNK3	1.13380145
31	CCNB1	1.08282358
32	VRK2	1.05493274
33	PLK3	1.02976319
34	PLK2	1.01477799
35	YES1	1.00819931
36	STK39	0.93954808
37	TSSK6	0.92695152
38	CSNK1G2	0.90972338
39	CSNK1G3	0.86498143
40	TTK	0.85988487
41	TESK1	0.82011719
42	FGFR2	0.80991319
43	CSNK1A1L	0.75856314
44	CSNK1G1	0.74828002
45	EPHA3	0.72301851
46	ERBB3	0.70988068
47	PAK3	0.69759551
48	INSRR	0.69009347
49	ADRBK2	0.68187893
50	MAP2K6	0.67765518
51	MAP3K12	0.67507835
52	ATM	0.66729108
53	LATS1	0.65563712
54	NEK1	0.65045190
55	PRKCE	0.63873559
56	AURKA	0.62367156
57	MAP3K4	0.60557390
58	CASK	0.59755142
59	TNK2	0.58911578
60	BRAF	0.57174747
61	STK3	0.55365419
62	PTK2B	0.55249280
63	MET	0.54503929
64	WNK4	0.53839077
65	DYRK3	0.52998564
66	RPS6KA5	0.52647653
67	MAPKAPK5	0.52281313
68	CDK3	0.51860064
69	ATR	0.51640829
70	PRKACB	0.51250998
71	STK24	0.48599024
72	ABL2	0.47973845
73	PRKCG	0.47944296
74	CAMK2D	0.47872506
75	FER	0.44583287
76	BRSK1	0.43598344
77	TAOK3	0.43273591
78	CAMK2A	0.42993073
79	PRKCI	0.41278005
80	CHEK1	0.39760083
81	CSNK2A1	0.38960239
82	EIF2AK3	0.38617983
83	EGFR	0.38292670
84	CAMK1G	0.38111484
85	DYRK1A	0.35601950
86	MAP3K2	0.33049879
87	PINK1	0.32940974
88	STK38	0.32486100
89	UHMK1	0.32355834
90	AURKB	0.30885122
91	PRKG1	0.30481194
92	NTRK3	0.29952992
93	BMX	0.29546678
94	CSNK2A2	0.28984044
95	MAPK15	0.28885674
96	SGK1	0.28497836
97	MAP3K3	0.28251824
98	PRKACA	0.27515482
99	IGF1R	0.25737425
100	NME2	0.25242712

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Maturity onset diabetes of the young_Homo sapiens_hsa04950	3.72685601
2	Homologous recombination_Homo sapiens_hsa03440	3.50118991
3	Proteasome_Homo sapiens_hsa03050	3.07052269
4	Fatty acid elongation_Homo sapiens_hsa00062	2.83579480
5	Protein export_Homo sapiens_hsa03060	2.71752104
6	Oxidative phosphorylation_Homo sapiens_hsa00190	2.64290610
7	Mismatch repair_Homo sapiens_hsa03430	2.56272278
8	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.55440048
9	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.40508386
10	Parkinsons disease_Homo sapiens_hsa05012	2.38759001
11	Propanoate metabolism_Homo sapiens_hsa00640	2.16331412
12	Fanconi anemia pathway_Homo sapiens_hsa03460	2.11149267
13	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.99027179
14	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.92571424
15	Butanoate metabolism_Homo sapiens_hsa00650	1.76384220
16	Non-homologous end-joining_Homo sapiens_hsa03450	1.76076750
17	Huntingtons disease_Homo sapiens_hsa05016	1.72926835
18	RNA degradation_Homo sapiens_hsa03018	1.69457908
19	Oocyte meiosis_Homo sapiens_hsa04114	1.66837525
20	Regulation of autophagy_Homo sapiens_hsa04140	1.65563295
21	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.64631352
22	Circadian rhythm_Homo sapiens_hsa04710	1.59596827
23	Basal transcription factors_Homo sapiens_hsa03022	1.57241819
24	Selenocompound metabolism_Homo sapiens_hsa00450	1.56477668
25	DNA replication_Homo sapiens_hsa03030	1.51868377
26	Peroxisome_Homo sapiens_hsa04146	1.42549107
27	Tryptophan metabolism_Homo sapiens_hsa00380	1.39482808
28	Collecting duct acid secretion_Homo sapiens_hsa04966	1.38536765
29	Caffeine metabolism_Homo sapiens_hsa00232	1.33417446
30	Alzheimers disease_Homo sapiens_hsa05010	1.32955269
31	Nucleotide excision repair_Homo sapiens_hsa03420	1.28522091
32	RNA transport_Homo sapiens_hsa03013	1.28152212
33	RNA polymerase_Homo sapiens_hsa03020	1.28084549
34	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.27319892
35	Base excision repair_Homo sapiens_hsa03410	1.24113727
36	beta-Alanine metabolism_Homo sapiens_hsa00410	1.21386867
37	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.19639899
38	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.17097964
39	Fatty acid metabolism_Homo sapiens_hsa01212	1.16882276
40	Insulin secretion_Homo sapiens_hsa04911	1.11021757
41	Steroid biosynthesis_Homo sapiens_hsa00100	1.08368038
42	Folate biosynthesis_Homo sapiens_hsa00790	1.07108432
43	Cardiac muscle contraction_Homo sapiens_hsa04260	0.99163520
44	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.96551180
45	Fatty acid degradation_Homo sapiens_hsa00071	0.96108192
46	Cell cycle_Homo sapiens_hsa04110	0.92465922
47	Pyrimidine metabolism_Homo sapiens_hsa00240	0.90164572
48	Pyruvate metabolism_Homo sapiens_hsa00620	0.88531500
49	Purine metabolism_Homo sapiens_hsa00230	0.82494523
50	Retinol metabolism_Homo sapiens_hsa00830	0.82194876
51	Metabolic pathways_Homo sapiens_hsa01100	0.80785479
52	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.80486283
53	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.79384447
54	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.79008819
55	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.76007973
56	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.75707094
57	Sulfur metabolism_Homo sapiens_hsa00920	0.75608716
58	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.75136439
59	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.74371700
60	Glutathione metabolism_Homo sapiens_hsa00480	0.72812675
61	Phototransduction_Homo sapiens_hsa04744	0.70261761
62	Nitrogen metabolism_Homo sapiens_hsa00910	0.67722276
63	Sphingolipid metabolism_Homo sapiens_hsa00600	0.67393311
64	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.66764063
65	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.65623891
66	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.64958124
67	Spliceosome_Homo sapiens_hsa03040	0.64547364
68	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.62613897
69	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.59879173
70	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.59630380
71	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.59569121
72	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.56591519
73	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.56314094
74	Ether lipid metabolism_Homo sapiens_hsa00565	0.53482198
75	Chemical carcinogenesis_Homo sapiens_hsa05204	0.52524387
76	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.51698786
77	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.50733549
78	Ribosome_Homo sapiens_hsa03010	0.49776217
79	Linoleic acid metabolism_Homo sapiens_hsa00591	0.48676181
80	mRNA surveillance pathway_Homo sapiens_hsa03015	0.48274237
81	Type I diabetes mellitus_Homo sapiens_hsa04940	0.46782678
82	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.42569736
83	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.42084894
84	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.41602076
85	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.38527658
86	Arginine biosynthesis_Homo sapiens_hsa00220	0.37106619
87	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.36341005
88	Carbon metabolism_Homo sapiens_hsa01200	0.35836476
89	One carbon pool by folate_Homo sapiens_hsa00670	0.35692385
90	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.35490597
91	Circadian entrainment_Homo sapiens_hsa04713	0.33323946
92	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.33093809
93	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.32908982
94	Vibrio cholerae infection_Homo sapiens_hsa05110	0.31940972
95	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.31890717
96	Glycerolipid metabolism_Homo sapiens_hsa00561	0.31578347
97	Arginine and proline metabolism_Homo sapiens_hsa00330	0.31148095
98	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.30016831
99	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.29514892
100	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.29101894

CXORF58

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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