ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of female gonad development (GO:2000194)	9.38128069
2	regulation of meiosis I (GO:0060631)	8.36878704
3	regulation of acrosome reaction (GO:0060046)	8.30373762
4	meiotic cell cycle (GO:0051321)	8.22188528
5	DNA methylation involved in gamete generation (GO:0043046)	7.99081399
6	oocyte development (GO:0048599)	7.55646040
7	synapsis (GO:0007129)	7.27913300
8	female gamete generation (GO:0007292)	7.00164801
9	multicellular organism reproduction (GO:0032504)	6.73831547
10	regulation of histone H3-K9 methylation (GO:0051570)	6.48628158
11	mitotic chromosome condensation (GO:0007076)	6.00070662
12	gene silencing by RNA (GO:0031047)	5.88370336
13	positive regulation of histone H3-K4 methylation (GO:0051571)	5.87353400
14	chromosome organization involved in meiosis (GO:0070192)	5.85414046
15	glycine transport (GO:0015816)	5.74225109
16	synaptonemal complex assembly (GO:0007130)	5.69024559
17	retinal cone cell development (GO:0046549)	5.68085492
18	male meiosis I (GO:0007141)	5.65391259
19	protein kinase C signaling (GO:0070528)	5.57292383
20	negative regulation of reproductive process (GO:2000242)	5.37500233
21	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	5.24294855
22	attachment of spindle microtubules to kinetochore (GO:0008608)	5.21693755
23	negative regulation of histone methylation (GO:0031061)	5.02743847
24	synaptonemal complex organization (GO:0070193)	5.02165567
25	positive regulation of humoral immune response (GO:0002922)	4.97192740
26	male meiosis (GO:0007140)	4.87973289
27	protein localization to chromosome, centromeric region (GO:0071459)	4.84911832
28	regulation of cell maturation (GO:1903429)	4.74451602
29	regulation of steroid hormone secretion (GO:2000831)	4.72591554
30	meiotic nuclear division (GO:0007126)	4.67037353
31	meiosis I (GO:0007127)	4.67016325
32	reproduction (GO:0000003)	4.50048921
33	protein localization to kinetochore (GO:0034501)	4.40995306
34	meiotic cell cycle process (GO:1903046)	4.35806133
35	regulation of meiosis (GO:0040020)	4.32283689
36	oogenesis (GO:0048477)	4.31084838
37	mitotic metaphase plate congression (GO:0007080)	4.29275373
38	L-amino acid import (GO:0043092)	4.27102556
39	binding of sperm to zona pellucida (GO:0007339)	4.18698103
40	positive regulation of gastrulation (GO:2000543)	4.05190987
41	fertilization (GO:0009566)	4.04533348
42	CENP-A containing nucleosome assembly (GO:0034080)	4.04331622
43	DNA alkylation (GO:0006305)	4.04181877
44	DNA methylation (GO:0006306)	4.04181877
45	positive regulation of reproductive process (GO:2000243)	3.96623593
46	sister chromatid cohesion (GO:0007062)	3.95949258
47	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	3.91638760
48	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	3.91638760
49	positive regulation of mitotic sister chromatid separation (GO:1901970)	3.91638760
50	positive regulation of histone methylation (GO:0031062)	3.89986058
51	regulation of meiotic cell cycle (GO:0051445)	3.87978623
52	positive regulation of chromosome segregation (GO:0051984)	3.83334410
53	protein localization to chromosome (GO:0034502)	3.80132867
54	gene silencing (GO:0016458)	3.79865941
55	translesion synthesis (GO:0019985)	3.78929009
56	centriole replication (GO:0007099)	3.72550395
57	positive regulation of meiosis (GO:0045836)	3.71413651
58	regulation of spindle organization (GO:0090224)	3.71314434
59	regulation of histone H3-K4 methylation (GO:0051569)	3.71097748
60	histone H3-K9 demethylation (GO:0033169)	3.69947099
61	chromatin remodeling at centromere (GO:0031055)	3.68162416
62	establishment of chromosome localization (GO:0051303)	3.56777299
63	regulation of histone methylation (GO:0031060)	3.56596973
64	positive regulation of uterine smooth muscle contraction (GO:0070474)	3.55055482
65	phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)	3.50185429
66	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	3.48320728
67	metaphase plate congression (GO:0051310)	3.46923080
68	positive regulation of meiotic cell cycle (GO:0051446)	3.45152443
69	primitive streak formation (GO:0090009)	3.44793454
70	regulation of steroid hormone biosynthetic process (GO:0090030)	3.43715574
71	labyrinthine layer development (GO:0060711)	3.42270862
72	phosphorelay signal transduction system (GO:0000160)	3.39273009
73	interkinetic nuclear migration (GO:0022027)	3.39263322
74	chromatin assembly (GO:0031497)	3.37938965
75	hyperosmotic salinity response (GO:0042538)	3.37147133
76	histone exchange (GO:0043486)	3.35395248
77	sperm-egg recognition (GO:0035036)	3.35131306
78	single fertilization (GO:0007338)	3.33721009
79	DNA replication-dependent nucleosome assembly (GO:0006335)	3.33489916
80	DNA replication-dependent nucleosome organization (GO:0034723)	3.33489916
81	regulation of cytokine production involved in inflammatory response (GO:1900015)	3.25355536
82	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	3.25001629
83	citrulline biosynthetic process (GO:0019240)	3.22521707
84	regulation of reproductive process (GO:2000241)	3.22147291
85	N-terminal protein amino acid acetylation (GO:0006474)	3.17795367
86	chromatin assembly or disassembly (GO:0006333)	3.13596806
87	negative regulation of execution phase of apoptosis (GO:1900118)	3.13330912
88	DNA replication-independent nucleosome organization (GO:0034724)	3.12057109
89	DNA replication-independent nucleosome assembly (GO:0006336)	3.12057109
90	paraxial mesoderm development (GO:0048339)	3.10975061
91	regulation of female receptivity (GO:0045924)	3.10781476
92	DNA replication checkpoint (GO:0000076)	3.08903267
93	nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)	3.08895619
94	regulation of spindle checkpoint (GO:0090231)	3.06955945
95	stress granule assembly (GO:0034063)	3.04467702
96	regulation of chromatin silencing (GO:0031935)	3.04202802
97	regulation of calcium ion-dependent exocytosis (GO:0017158)	3.02739185
98	negative regulation of hormone biosynthetic process (GO:0032353)	3.02221658
99	piRNA metabolic process (GO:0034587)	10.9207442
100	regulation of DNA methylation (GO:0044030)	10.3374794

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	4.13107379
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.03619325
3	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	3.36809382
4	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	3.36809382
5	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	3.36809382
6	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	3.23623592
7	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	3.10732917
8	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	3.02074471
9	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.68259506
10	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.42744763
11	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	2.35104693
12	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.32683550
13	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.24695798
14	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.24477295
15	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.12308753
16	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.07653836
17	EZH2_22144423_ChIP-Seq_EOC_Human	15.4380646
18	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.76917721
19	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.76075209
20	GBX2_23144817_ChIP-Seq_PC3_Human	1.70508926
21	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.66041970
22	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.64855874
23	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.51152389
24	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.46038285
25	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.43432154
26	AR_21909140_ChIP-Seq_LNCAP_Human	1.37299599
27	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.34820807
28	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.27527186
29	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.22937688
30	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.21491834
31	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.18431177
32	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.18021764
33	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.17859180
34	CBP_20019798_ChIP-Seq_JUKART_Human	1.17859180
35	TCF4_23295773_ChIP-Seq_U87_Human	1.14954254
36	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.12590306
37	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.12319525
38	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.11049595
39	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.10427759
40	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.08755212
41	IRF1_19129219_ChIP-ChIP_H3396_Human	1.08046548
42	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.05241127
43	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.05141972
44	AR_25329375_ChIP-Seq_VCAP_Human	1.03290395
45	RUNX2_22187159_ChIP-Seq_PCA_Human	1.01917738
46	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.99503901
47	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.98972927
48	HTT_18923047_ChIP-ChIP_STHdh_Human	0.97900857
49	NANOG_20526341_ChIP-Seq_ESCs_Human	0.96622552
50	SALL1_21062744_ChIP-ChIP_HESCs_Human	0.96522457
51	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.95948671
52	RNF2_27304074_Chip-Seq_NSC_Mouse	0.95536760
53	SMAD4_21799915_ChIP-Seq_A2780_Human	0.95306649
54	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	0.93376291
55	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	0.93266371
56	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.93120629
57	FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.90779144
58	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.89691347
59	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.89195822
60	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.88934873
61	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.88934873
62	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.85906496
63	GF1_26923725_Chip-Seq_HPCs_Mouse	0.85484396
64	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	0.84974451
65	EWS_26573619_Chip-Seq_HEK293_Human	0.84942284
66	STAT3_23295773_ChIP-Seq_U87_Human	0.84791249
67	ZNF274_21170338_ChIP-Seq_K562_Hela	0.83749920
68	GATA1_19941827_ChIP-Seq_MEL86_Mouse	0.82243747
69	CBP_21632823_ChIP-Seq_H3396_Human	0.81813142
70	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.80543424
71	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.80214678
72	SMAD_19615063_ChIP-ChIP_OVARY_Human	0.80204179
73	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.79489946
74	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.79441069
75	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.78163626
76	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.76726552
77	TP53_22573176_ChIP-Seq_HFKS_Human	0.76630072
78	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	0.75242926
79	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.72910495
80	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.72577084
81	AHR_22903824_ChIP-Seq_MCF-7_Human	0.72166811
82	PKCTHETA_26484144_Chip-Seq_BREAST_Human	0.72069487
83	RUNX1_26923725_Chip-Seq_HPCs_Mouse	0.70884292
84	CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	0.69850994
85	KLF4_19829295_ChIP-Seq_ESCs_Human	0.69525282
86	SMRT_27268052_Chip-Seq_Bcells_Human	0.68061185
87	REST_21632747_ChIP-Seq_MESCs_Mouse	0.68050820
88	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.67591311
89	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	0.66899866
90	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.66747170
91	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.66458706
92	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	0.65051691
93	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	0.64808867
94	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.64342045
95	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.62830993
96	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.62806595
97	P300_19829295_ChIP-Seq_ESCs_Human	0.62365070
98	BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human	0.61324740
99	BCAT_22108803_ChIP-Seq_LS180_Human	0.61244524
100	GATA3_26560356_Chip-Seq_TH1_Human	0.61153622

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003718_maternal_effect	8.32197370
2	MP0008877_abnormal_DNA_methylation	5.27153939
3	MP0006292_abnormal_olfactory_placode	3.76828468
4	MP0008789_abnormal_olfactory_epithelium	3.45772283
5	MP0005395_other_phenotype	3.42763991
6	MP0008057_abnormal_DNA_replication	3.36514741
7	MP0005394_taste/olfaction_phenotype	3.10197811
8	MP0005499_abnormal_olfactory_system	3.10197811
9	MP0005360_urolithiasis	2.90007026
10	MP0003890_abnormal_embryonic-extraembry	2.83693394
11	MP0002210_abnormal_sex_determination	2.77785003
12	MP0001929_abnormal_gametogenesis	2.76783601
13	MP0002139_abnormal_hepatobiliary_system	2.75327472
14	MP0010234_abnormal_vibrissa_follicle	2.74573009
15	MP0003693_abnormal_embryo_hatching	2.72619201
16	MP0003879_abnormal_hair_cell	2.70026137
17	MP0003699_abnormal_female_reproductive	2.63121544
18	MP0008058_abnormal_DNA_repair	2.40562683
19	MP0010030_abnormal_orbit_morphology	2.22682567
20	MP0000653_abnormal_sex_gland	2.14798354
21	MP0002138_abnormal_hepatobiliary_system	2.10348783
22	MP0003077_abnormal_cell_cycle	2.06693031
23	MP0003183_abnormal_peptide_metabolism	2.02213883
24	MP0010094_abnormal_chromosome_stability	1.92182975
25	MP0000566_synostosis	1.90129964
26	MP0002161_abnormal_fertility/fecundity	1.83891738
27	MP0001145_abnormal_male_reproductive	1.81228581
28	MP0002234_abnormal_pharynx_morphology	1.80280820
29	MP0003950_abnormal_plasma_membrane	1.73962681
30	MP0002160_abnormal_reproductive_system	1.73839964
31	MP0003111_abnormal_nucleus_morphology	1.69787142
32	MP0001119_abnormal_female_reproductive	1.61400279
33	MP0005410_abnormal_fertilization	1.57618209
34	MP0010368_abnormal_lymphatic_system	1.54684126
35	MP0003698_abnormal_male_reproductive	1.54218259
36	MP0010307_abnormal_tumor_latency	1.50128419
37	MP0009840_abnormal_foam_cell	1.42534598
38	MP0008932_abnormal_embryonic_tissue	1.37947597
39	MP0001730_embryonic_growth_arrest	1.33043429
40	MP0001986_abnormal_taste_sensitivity	1.30208984
41	MP0000631_abnormal_neuroendocrine_gland	1.28589506
42	MP0005389_reproductive_system_phenotype	1.24541748
43	MP0005646_abnormal_pituitary_gland	1.23133299
44	MP0004142_abnormal_muscle_tone	1.20964448
45	MP0000427_abnormal_hair_cycle	1.19552132
46	MP0003121_genomic_imprinting	1.16975855
47	MP0001293_anophthalmia	1.13067011
48	MP0000762_abnormal_tongue_morphology	1.11295780
49	MP0005647_abnormal_sex_gland	1.09853043
50	MP0010678_abnormal_skin_adnexa	1.09281348
51	MP0009379_abnormal_foot_pigmentation	1.07977342
52	MP0002233_abnormal_nose_morphology	1.02843715
53	MP0003252_abnormal_bile_duct	1.02410350
54	MP0001672_abnormal_embryogenesis/_devel	0.99421316
55	MP0005380_embryogenesis_phenotype	0.99421316
56	MP0003941_abnormal_skin_development	0.99185925
57	MP0000678_abnormal_parathyroid_gland	0.94510094
58	MP0003136_yellow_coat_color	0.93206467
59	MP0002272_abnormal_nervous_system	0.92616076
60	MP0006276_abnormal_autonomic_nervous	0.88071493
61	MP0002796_impaired_skin_barrier	0.87232960
62	MP0003119_abnormal_digestive_system	0.86817272
63	MP0000350_abnormal_cell_proliferation	0.84452872
64	MP0001984_abnormal_olfaction	0.76821763
65	MP0005085_abnormal_gallbladder_physiolo	0.72509745
66	MP0004957_abnormal_blastocyst_morpholog	0.72380590
67	MP0001664_abnormal_digestion	0.71467622
68	MP0005501_abnormal_skin_physiology	0.68495657
69	MP0002084_abnormal_developmental_patter	0.66264433
70	MP0000049_abnormal_middle_ear	0.66051000
71	MP0001502_abnormal_circadian_rhythm	0.65499628
72	MP0001963_abnormal_hearing_physiology	0.63492292
73	MP0001666_abnormal_nutrient_absorption	0.62682562
74	MP0001324_abnormal_eye_pigmentation	0.61343097
75	MP0005551_abnormal_eye_electrophysiolog	0.59461302
76	MP0005075_abnormal_melanosome_morpholog	0.56005259
77	MP0000015_abnormal_ear_pigmentation	0.55145757
78	MP0003868_abnormal_feces_composition	0.54834202
79	MP0002089_abnormal_postnatal_growth/wei	0.54344130
80	MP0008995_early_reproductive_senescence	0.51189402
81	MP0002085_abnormal_embryonic_tissue	0.50153590
82	MP0000383_abnormal_hair_follicle	0.49519830
83	MP0001697_abnormal_embryo_size	0.48796479
84	MP0002735_abnormal_chemical_nociception	0.48608329
85	MP0003935_abnormal_craniofacial_develop	0.47582599
86	MP0005076_abnormal_cell_differentiation	0.46304974
87	MP0005174_abnormal_tail_pigmentation	0.44749898
88	MP0004381_abnormal_hair_follicle	0.43633200
89	MP0002127_abnormal_cardiovascular_syste	0.42937705
90	MP0003984_embryonic_growth_retardation	0.42804060
91	MP0002095_abnormal_skin_pigmentation	0.41372147
92	MP0003936_abnormal_reproductive_system	0.41238115
93	MP0003959_abnormal_lean_body	0.40461384
94	MP0002734_abnormal_mechanical_nocicepti	0.40228009
95	MP0002088_abnormal_embryonic_growth/wei	0.39947197
96	MP0005503_abnormal_tendon_morphology	0.38810556
97	MP0002873_normal_phenotype	0.38673552
98	MP0001919_abnormal_reproductive_system	0.38564076
99	MP0002638_abnormal_pupillary_reflex	0.38486417
100	MP0002169_no_abnormal_phenotype	0.38225844

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Osteomalacia (HP:0002749)	5.69751597
2	Male infertility (HP:0003251)	5.47870048
3	Lip pit (HP:0100267)	4.99769519
4	Supernumerary spleens (HP:0009799)	4.89273908
5	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	4.81937578
6	Azoospermia (HP:0000027)	4.71629463
7	Papillary thyroid carcinoma (HP:0002895)	4.69585899
8	Abdominal situs inversus (HP:0003363)	4.55132923
9	Abnormality of abdominal situs (HP:0011620)	4.55132923
10	Gonadotropin excess (HP:0000837)	4.49281591
11	Facial hemangioma (HP:0000329)	4.47100744
12	Hypophosphatemic rickets (HP:0004912)	4.44743035
13	Aplasia/Hypoplasia of the fovea (HP:0008060)	4.36530824
14	Hypoplasia of the fovea (HP:0007750)	4.36530824
15	Premature ovarian failure (HP:0008209)	4.29255715
16	Infertility (HP:0000789)	4.23934184
17	Anterior segment dysgenesis (HP:0007700)	4.17279197
18	Impulsivity (HP:0100710)	4.10016648
19	Oligodactyly (hands) (HP:0001180)	3.94299410
20	Abnormal gallbladder physiology (HP:0012438)	3.89092987
21	Cholecystitis (HP:0001082)	3.89092987
22	Abnormality of the fovea (HP:0000493)	3.82603796
23	Chromsome breakage (HP:0040012)	3.69765584
24	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.64404811
25	Abnormal spermatogenesis (HP:0008669)	3.55682824
26	Malnutrition (HP:0004395)	3.53307139
27	Septo-optic dysplasia (HP:0100842)	3.39009480
28	Median cleft lip (HP:0000161)	3.30238238
29	Conjunctival telangiectasia (HP:0000524)	3.17663201
30	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	3.16626128
31	Loss of speech (HP:0002371)	3.11943868
32	Urethral obstruction (HP:0000796)	2.99078977
33	Absent septum pellucidum (HP:0001331)	2.94716044
34	Oligodactyly (HP:0012165)	2.93296262
35	Short tibia (HP:0005736)	2.87902211
36	Apathy (HP:0000741)	2.83240140
37	Diminished motivation (HP:0000745)	2.82201746
38	Capillary hemangiomas (HP:0005306)	2.80073968
39	Truncal obesity (HP:0001956)	2.76668244
40	Proximal tubulopathy (HP:0000114)	2.75826981
41	Hypokinesia (HP:0002375)	2.74591192
42	Aplasia/Hypoplasia of the macula (HP:0008059)	2.72805650
43	Muscle stiffness (HP:0003552)	2.72204594
44	Abnormality of the labia minora (HP:0012880)	2.66677727
45	Metaphyseal irregularity (HP:0003025)	2.58666061
46	Spinal cord compression (HP:0002176)	2.54710089
47	Skin pits (HP:0100276)	2.54217637
48	Aplasia of the musculature (HP:0100854)	2.53873955
49	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.52619232
50	Thyroid carcinoma (HP:0002890)	2.52394512
51	Aplasia/Hypoplasia affecting the retina (HP:0008061)	2.48810421
52	Generalized aminoaciduria (HP:0002909)	2.47411116
53	Abnormality of the vasculature of the conjunctiva (HP:0008054)	2.46168968
54	Abnormality of the septum pellucidum (HP:0007375)	2.38745591
55	Wrist flexion contracture (HP:0001239)	2.37708290
56	Enlarged penis (HP:0000040)	2.34984915
57	Abnormal lung lobation (HP:0002101)	2.34840552
58	Lower limb hyperreflexia (HP:0002395)	2.33450798
59	Myokymia (HP:0002411)	2.27054729
60	Bundle branch block (HP:0011710)	2.20885484
61	Fair hair (HP:0002286)	2.19111362
62	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.18307086
63	Hydroureter (HP:0000072)	2.10427123
64	Dysdiadochokinesis (HP:0002075)	2.08277507
65	Abnormality of the phalanges of the hallux (HP:0010057)	2.05912508
66	Anhidrosis (HP:0000970)	2.05524493
67	Sensory axonal neuropathy (HP:0003390)	2.02962637
68	Nephroblastoma (Wilms tumor) (HP:0002667)	2.01870054
69	Rickets (HP:0002748)	2.01287622
70	Striae distensae (HP:0001065)	2.01004793
71	Increased circulating renin level (HP:0000848)	1.99173959
72	Heterotopia (HP:0002282)	1.97931416
73	Small intestinal stenosis (HP:0012848)	1.94126998
74	Duodenal stenosis (HP:0100867)	1.94126998
75	Abnormality of calcium-phosphate metabolism (HP:0100530)	1.93137320
76	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.92745958
77	Abnormality of chromosome segregation (HP:0002916)	1.91690952
78	Maternal diabetes (HP:0009800)	1.91066112
79	Stillbirth (HP:0003826)	1.89837855
80	Embryonal renal neoplasm (HP:0011794)	1.89059987
81	Posterior subcapsular cataract (HP:0007787)	1.87517201
82	Microglossia (HP:0000171)	1.86959735
83	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	1.83225089
84	Abnormal ciliary motility (HP:0012262)	1.82996176
85	Abnormality of chromosome stability (HP:0003220)	1.81053124
86	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.77545565
87	Hypergonadotropic hypogonadism (HP:0000815)	1.76871141
88	Nausea (HP:0002018)	1.75311478
89	Abnormality of the salivary glands (HP:0010286)	1.73643026
90	Intrahepatic cholestasis (HP:0001406)	1.73243716
91	Abnormality of the anterior chamber (HP:0000593)	1.72751273
92	Cleft eyelid (HP:0000625)	1.71761652
93	Bile duct proliferation (HP:0001408)	1.71630625
94	Abnormal biliary tract physiology (HP:0012439)	1.71630625
95	Neurofibrillary tangles (HP:0002185)	1.70577935
96	Neoplasm of the oral cavity (HP:0100649)	1.68611484
97	Abnormality of the labia (HP:0000058)	1.67072507
98	Abnormal urine phosphate concentration (HP:0012599)	1.66668658
99	Non-midline cleft lip (HP:0100335)	1.66261180
100	Cranial hyperostosis (HP:0004437)	1.65897485

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP3K9	6.72127360
2	MAP3K13	6.32166191
3	ARAF	6.16248008
4	STK24	3.22367793
5	BRAF	3.08424543
6	TTK	2.82628846
7	MOS	2.73610505
8	NEK6	2.73315643
9	MET	2.61358719
10	TAOK3	2.51016896
11	KSR2	2.43722749
12	CDK12	2.21688135
13	AURKA	2.03471055
14	CDK19	2.01329041
15	RAF1	1.90983239
16	CDC7	1.70579424
17	KSR1	1.57161319
18	EIF2AK3	1.46046281
19	CDK9	1.45129436
20	PRKCI	1.38906992
21	NTRK2	1.37087216
22	BUB1	1.32845453
23	PNCK	1.31686644
24	PLK1	1.29114285
25	CDK7	1.26740263
26	STK3	1.21916684
27	TRIM28	1.20520613
28	MELK	1.20274927
29	PTK2	1.18603007
30	BRSK1	1.09142847
31	TNIK	1.08824784
32	NTRK3	0.98861435
33	CAMK1G	0.95095467
34	PIM1	0.93379911
35	MAP3K8	0.91445601
36	CHEK1	0.87676141
37	NEK2	0.86801289
38	WNK1	0.86250283
39	BMPR1B	0.81121019
40	CAMK1D	0.77595316
41	ZAK	0.74282338
42	CDK8	0.67668966
43	TNK2	0.66267345
44	NEK9	0.65057986
45	CDK2	0.64919847
46	STK39	0.64235311
47	ACVR1B	0.60265982
48	PLK3	0.57589761
49	MARK3	0.57143744
50	CSNK1G1	0.57110646
51	ATM	0.55693521
52	MAPKAPK3	0.53298259
53	AURKB	0.52027852
54	DMPK	0.51552791
55	CHEK2	0.51031640
56	TYRO3	0.51007753
57	NUAK1	0.50466196
58	MAP3K4	0.50184246
59	TIE1	0.49134533
60	ATR	0.48391925
61	PAK1	0.47719978
62	LRRK2	0.46617645
63	TGFBR1	0.45003004
64	OXSR1	0.43975002
65	PRKG1	0.43772331
66	CDK1	0.43352277
67	BRSK2	0.41249204
68	EEF2K	0.40415703
69	PDK1	0.39461436
70	MTOR	0.39169246
71	PRKCZ	0.36655114
72	MAP3K5	0.35939804
73	MAPK13	0.32543598
74	MST4	0.32455063
75	PKN1	0.32389267
76	CSNK1D	0.31666889
77	TLK1	0.31360291
78	CSNK1E	0.29225481
79	VRK1	0.28754328
80	CDK5	0.27480431
81	LATS1	0.27010626
82	CSNK1G3	0.26461849
83	PLK4	0.25837689
84	AKT2	0.25128213
85	PDPK1	0.24772714
86	EGFR	0.23121565
87	GSK3B	0.22242335
88	PRKACB	0.21896059
89	CDK11A	0.21824542
90	BRD4	0.21810514
91	MAP3K1	0.21161034
92	SRPK1	0.20228210
93	STK38	0.19524315
94	CAMK2A	0.19341774
95	TRPM7	0.18502063
96	MAPK10	0.18381806
97	MAPK1	0.18258148
98	PBK	0.16730162
99	CAMK1	0.16602857
100	MAP2K1	0.15794901

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Basal transcription factors_Homo sapiens_hsa03022	5.44854715
2	Cell cycle_Homo sapiens_hsa04110	4.60455269
3	Mismatch repair_Homo sapiens_hsa03430	4.29311081
4	Oocyte meiosis_Homo sapiens_hsa04114	3.55029309
5	Base excision repair_Homo sapiens_hsa03410	3.39927501
6	Dorso-ventral axis formation_Homo sapiens_hsa04320	3.03584859
7	Ovarian steroidogenesis_Homo sapiens_hsa04913	3.01100879
8	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.91141923
9	DNA replication_Homo sapiens_hsa03030	2.86545331
10	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	2.71953366
11	Caffeine metabolism_Homo sapiens_hsa00232	2.66545909
12	RNA degradation_Homo sapiens_hsa03018	2.59701449
13	Nucleotide excision repair_Homo sapiens_hsa03420	2.51128673
14	Fanconi anemia pathway_Homo sapiens_hsa03460	2.38717806
15	Homologous recombination_Homo sapiens_hsa03440	2.23199030
16	RNA transport_Homo sapiens_hsa03013	1.99042426
17	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.91626955
18	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.83030868
19	Olfactory transduction_Homo sapiens_hsa04740	1.80240062
20	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.79723070
21	Circadian rhythm_Homo sapiens_hsa04710	1.70317330
22	p53 signaling pathway_Homo sapiens_hsa04115	1.67816728
23	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.48537992
24	Thyroid cancer_Homo sapiens_hsa05216	1.45219767
25	RNA polymerase_Homo sapiens_hsa03020	1.40125363
26	mRNA surveillance pathway_Homo sapiens_hsa03015	1.36672951
27	Folate biosynthesis_Homo sapiens_hsa00790	1.36189204
28	Gap junction_Homo sapiens_hsa04540	1.30120336
29	Fatty acid elongation_Homo sapiens_hsa00062	1.13296423
30	ABC transporters_Homo sapiens_hsa02010	1.07788562
31	Phototransduction_Homo sapiens_hsa04744	1.06574813
32	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.89008549
33	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.88035204
34	Nicotine addiction_Homo sapiens_hsa05033	0.87013250
35	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.82729349
36	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.81531375
37	mTOR signaling pathway_Homo sapiens_hsa04150	0.79732544
38	Taste transduction_Homo sapiens_hsa04742	0.75387204
39	Bile secretion_Homo sapiens_hsa04976	0.74023292
40	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.68429023
41	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.65765906
42	Regulation of autophagy_Homo sapiens_hsa04140	0.65484366
43	Morphine addiction_Homo sapiens_hsa05032	0.65160612
44	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.64170935
45	Long-term depression_Homo sapiens_hsa04730	0.63016299
46	Viral carcinogenesis_Homo sapiens_hsa05203	0.61059444
47	FoxO signaling pathway_Homo sapiens_hsa04068	0.60741651
48	GABAergic synapse_Homo sapiens_hsa04727	0.60042313
49	Adherens junction_Homo sapiens_hsa04520	0.51284383
50	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.50395611
51	Small cell lung cancer_Homo sapiens_hsa05222	0.49283919
52	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.47955079
53	Serotonergic synapse_Homo sapiens_hsa04726	0.46709957
54	Purine metabolism_Homo sapiens_hsa00230	0.46335096
55	ErbB signaling pathway_Homo sapiens_hsa04012	0.45721129
56	MicroRNAs in cancer_Homo sapiens_hsa05206	0.45625021
57	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.42988646
58	Notch signaling pathway_Homo sapiens_hsa04330	0.40111547
59	Herpes simplex infection_Homo sapiens_hsa05168	0.37741205
60	HTLV-I infection_Homo sapiens_hsa05166	0.34931060
61	Huntingtons disease_Homo sapiens_hsa05016	0.34108785
62	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.32755376
63	Propanoate metabolism_Homo sapiens_hsa00640	0.31743342
64	Wnt signaling pathway_Homo sapiens_hsa04310	0.29356438
65	Arginine biosynthesis_Homo sapiens_hsa00220	0.28694206
66	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.26035089
67	Non-homologous end-joining_Homo sapiens_hsa03450	0.25456584
68	Ras signaling pathway_Homo sapiens_hsa04014	0.24753847
69	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.23136170
70	Pyrimidine metabolism_Homo sapiens_hsa00240	0.22892827
71	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.22227637
72	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.22167851
73	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.22047359
74	Endometrial cancer_Homo sapiens_hsa05213	0.21295229
75	Hippo signaling pathway_Homo sapiens_hsa04390	0.20920188
76	Arginine and proline metabolism_Homo sapiens_hsa00330	0.19629921
77	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.19211840
78	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.18076224
79	Protein digestion and absorption_Homo sapiens_hsa04974	0.17132088
80	Cholinergic synapse_Homo sapiens_hsa04725	0.15480266
81	Prostate cancer_Homo sapiens_hsa05215	0.14548257
82	Renal cell carcinoma_Homo sapiens_hsa05211	0.14472607
83	Spliceosome_Homo sapiens_hsa03040	0.13057279
84	Lysine degradation_Homo sapiens_hsa00310	0.12777212
85	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.12365968
86	MAPK signaling pathway_Homo sapiens_hsa04010	0.11202819
87	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.10498532
88	Linoleic acid metabolism_Homo sapiens_hsa00591	0.10236602
89	Non-small cell lung cancer_Homo sapiens_hsa05223	0.10156830
90	Hepatitis B_Homo sapiens_hsa05161	0.09888512
91	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.09421231
92	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.09041411
93	cAMP signaling pathway_Homo sapiens_hsa04024	0.08907498
94	Long-term potentiation_Homo sapiens_hsa04720	0.08622349
95	Prion diseases_Homo sapiens_hsa05020	0.08107054
96	Glutamatergic synapse_Homo sapiens_hsa04724	0.07114090
97	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.05395574
98	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.04524242
99	Pyruvate metabolism_Homo sapiens_hsa00620	0.04232463
100	Calcium signaling pathway_Homo sapiens_hsa04020	0.04223448

CXORF67

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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