ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	tachykinin receptor signaling pathway (GO:0007217)	7.22820904
2	response to pheromone (GO:0019236)	6.46669902
3	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	5.57529138
4	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	5.42386322
5	positive regulation of action potential (GO:0045760)	5.37704491
6	positive regulation of synaptic transmission, GABAergic (GO:0032230)	5.05073384
7	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	5.02362275
8	regulation of hypersensitivity (GO:0002883)	4.94106259
9	behavioral response to ethanol (GO:0048149)	4.84641928
10	regulation of glucocorticoid secretion (GO:2000849)	4.36498531
11	positive regulation of mitochondrial fission (GO:0090141)	4.33233745
12	anterograde synaptic vesicle transport (GO:0048490)	4.18630638
13	cullin deneddylation (GO:0010388)	4.09749603
14	negative regulation of heart rate (GO:0010459)	4.09346667
15	inositol phosphate catabolic process (GO:0071545)	3.93844199
16	protein deneddylation (GO:0000338)	3.92989647
17	somite development (GO:0061053)	3.88399846
18	protein-chromophore linkage (GO:0018298)	3.87704554
19	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.84792465
20	positive regulation of digestive system process (GO:0060456)	3.60613100
21	microtubule nucleation (GO:0007020)	3.57103282
22	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	3.56478480
23	C4-dicarboxylate transport (GO:0015740)	3.45184818
24	neuron cell-cell adhesion (GO:0007158)	3.42708419
25	polyol catabolic process (GO:0046174)	3.40970420
26	negative regulation of exocytosis (GO:0045920)	3.40668885
27	regulation of acrosome reaction (GO:0060046)	3.40618634
28	regulation of corticosteroid hormone secretion (GO:2000846)	3.39464851
29	regulation of action potential (GO:0098900)	3.33528502
30	positive regulation of steroid hormone secretion (GO:2000833)	3.31403518
31	regulation of acute inflammatory response to antigenic stimulus (GO:0002864)	3.29113156
32	peroxisome fission (GO:0016559)	3.22030706
33	presynaptic membrane assembly (GO:0097105)	3.19635184
34	synapsis (GO:0007129)	3.15219152
35	negative regulation of smooth muscle cell differentiation (GO:0051151)	3.13102322
36	establishment of protein localization to Golgi (GO:0072600)	3.10970034
37	cilium or flagellum-dependent cell motility (GO:0001539)	3.06863451
38	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	3.02701961
39	anterograde axon cargo transport (GO:0008089)	3.01364923
40	positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	3.00099449
41	signal peptide processing (GO:0006465)	2.97328383
42	protein targeting to Golgi (GO:0000042)	2.96187393
43	secondary metabolite biosynthetic process (GO:0044550)	2.94966138
44	prostate gland growth (GO:0060736)	2.93855795
45	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.91967300
46	inositol phosphate dephosphorylation (GO:0046855)	2.91967300
47	cornea development in camera-type eye (GO:0061303)	2.90159435
48	response to methylmercury (GO:0051597)	2.89483101
49	cell wall macromolecule catabolic process (GO:0016998)	2.87712635
50	positive regulation of mast cell degranulation (GO:0043306)	2.87350337
51	positive regulation of mast cell activation involved in immune response (GO:0033008)	2.87350337
52	transepithelial transport (GO:0070633)	2.87106044
53	negative regulation of neurological system process (GO:0031645)	2.86908399
54	fatty acid elongation (GO:0030497)	2.85911494
55	dopamine transport (GO:0015872)	2.85881908
56	sleep (GO:0030431)	2.85842396
57	pyrimidine nucleobase catabolic process (GO:0006208)	2.85549764
58	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.83157891
59	regulation of hexokinase activity (GO:1903299)	2.74646974
60	regulation of glucokinase activity (GO:0033131)	2.74646974
61	melanin biosynthetic process (GO:0042438)	2.73680948
62	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.72335885
63	negative regulation of cAMP-mediated signaling (GO:0043951)	2.71531472
64	resolution of meiotic recombination intermediates (GO:0000712)	2.70815510
65	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.70668177
66	startle response (GO:0001964)	2.70571472
67	regulation of steroid hormone secretion (GO:2000831)	2.69668082
68	retinal cone cell development (GO:0046549)	2.69390324
69	intra-Golgi vesicle-mediated transport (GO:0006891)	2.68870599
70	regulation of mitochondrial fission (GO:0090140)	2.67408748
71	dicarboxylic acid catabolic process (GO:0043649)	2.65738102
72	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.63159509
73	limb bud formation (GO:0060174)	2.63084860
74	piRNA metabolic process (GO:0034587)	2.62969180
75	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	2.61365863
76	protein localization to Golgi apparatus (GO:0034067)	2.60763459
77	DNA integration (GO:0015074)	2.59847995
78	neurotransmitter biosynthetic process (GO:0042136)	2.59624679
79	positive regulation of catecholamine secretion (GO:0033605)	2.58559309
80	axoneme assembly (GO:0035082)	2.58166323
81	neural tube formation (GO:0001841)	2.57368719
82	reciprocal meiotic recombination (GO:0007131)	2.56492761
83	reciprocal DNA recombination (GO:0035825)	2.56492761
84	neuronal action potential (GO:0019228)	2.55202840
85	protein-cofactor linkage (GO:0018065)	2.54430272
86	membrane depolarization during action potential (GO:0086010)	2.52130940
87	glucosamine-containing compound catabolic process (GO:1901072)	2.51828349
88	protein neddylation (GO:0045116)	2.51033663
89	regulation of meiosis I (GO:0060631)	2.50540293
90	photoreceptor cell maintenance (GO:0045494)	2.50500692
91	rhodopsin mediated signaling pathway (GO:0016056)	2.47877740
92	platelet dense granule organization (GO:0060155)	2.47853635
93	negative regulation of mast cell activation (GO:0033004)	2.47253393
94	negative regulation of cell aging (GO:0090344)	2.47069526
95	protein K11-linked ubiquitination (GO:0070979)	2.46369722
96	snRNA processing (GO:0016180)	2.46236820
97	monoamine transport (GO:0015844)	2.46199651
98	behavioral response to nicotine (GO:0035095)	2.46114794
99	positive regulation of amine transport (GO:0051954)	2.45284464
100	ionotropic glutamate receptor signaling pathway (GO:0035235)	2.44759084

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.48578289
2	POU3F2_20337985_ChIP-ChIP_501MEL_Human	3.23830286
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.18793753
4	EZH2_22144423_ChIP-Seq_EOC_Human	3.14227684
5	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.95754825
6	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.79095038
7	FUS_26573619_Chip-Seq_HEK293_Human	2.39604166
8	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.38225009
9	VDR_22108803_ChIP-Seq_LS180_Human	2.32463525
10	IGF1R_20145208_ChIP-Seq_DFB_Human	2.30417184
11	P300_19829295_ChIP-Seq_ESCs_Human	2.22802965
12	TAF15_26573619_Chip-Seq_HEK293_Human	2.15842562
13	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.09318169
14	EWS_26573619_Chip-Seq_HEK293_Human	2.06675646
15	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.05407916
16	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.04408854
17	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.03920092
18	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.95446001
19	ER_23166858_ChIP-Seq_MCF-7_Human	1.92925798
20	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.92304613
21	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.90663203
22	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.89824005
23	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.87838615
24	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.87567429
25	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.82079035
26	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.78479646
27	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.77722307
28	SMAD4_21799915_ChIP-Seq_A2780_Human	1.73515764
29	AR_21572438_ChIP-Seq_LNCaP_Human	1.71215928
30	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.66049819
31	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.62990809
32	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.62966224
33	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.62751266
34	ELK1_19687146_ChIP-ChIP_HELA_Human	1.58052870
35	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.57544402
36	STAT3_23295773_ChIP-Seq_U87_Human	1.56541463
37	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.53112862
38	NANOG_19829295_ChIP-Seq_ESCs_Human	1.49420454
39	SOX2_19829295_ChIP-Seq_ESCs_Human	1.49420454
40	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.48611894
41	TCF4_23295773_ChIP-Seq_U87_Human	1.45671213
42	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.45548027
43	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.44125849
44	AR_25329375_ChIP-Seq_VCAP_Human	1.43782626
45	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.42839662
46	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.39396582
47	TP53_22573176_ChIP-Seq_HFKS_Human	1.38575664
48	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.36223952
49	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.34064821
50	VDR_23849224_ChIP-Seq_CD4+_Human	1.31794741
51	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.31499057
52	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.31160965
53	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.30955458
54	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.29692078
55	CBP_20019798_ChIP-Seq_JUKART_Human	1.29692078
56	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.28242780
57	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.28182995
58	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.26555925
59	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.25839057
60	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.25520426
61	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.24156433
62	TP53_16413492_ChIP-PET_HCT116_Human	1.21868378
63	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.21791040
64	RUNX2_22187159_ChIP-Seq_PCA_Human	1.21722370
65	AR_20517297_ChIP-Seq_VCAP_Human	1.20644411
66	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.19724974
67	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.17837742
68	BCAT_22108803_ChIP-Seq_LS180_Human	1.17598901
69	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.16040216
70	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.16017095
71	FOXP3_21729870_ChIP-Seq_TREG_Human	1.15272848
72	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.14493268
73	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.14493268
74	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.13478809
75	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.13464755
76	HTT_18923047_ChIP-ChIP_STHdh_Human	1.12383313
77	RNF2_27304074_Chip-Seq_NSC_Mouse	1.11935526
78	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.11915206
79	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.11705279
80	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.11659719
81	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.11659719
82	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.11520046
83	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.09378335
84	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.07891681
85	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.07723110
86	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.06950737
87	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.06822894
88	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.06335951
89	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.06094205
90	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.05661611
91	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.05027324
92	TCF4_22108803_ChIP-Seq_LS180_Human	1.04419054
93	P53_22387025_ChIP-Seq_ESCs_Mouse	1.03941344
94	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.02351882
95	SALL4_22934838_ChIP-ChIP_CD34+_Human	1.00491838
96	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.00202624
97	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.99323901
98	CDX2_22108803_ChIP-Seq_LS180_Human	0.99102576
99	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.98660001
100	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	0.97828378

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	4.52317879
2	MP0002102_abnormal_ear_morphology	4.35335672
3	MP0000372_irregular_coat_pigmentation	3.93243628
4	MP0002837_dystrophic_cardiac_calcinosis	3.35947109
5	MP0010386_abnormal_urinary_bladder	3.23637234
6	MP0002638_abnormal_pupillary_reflex	2.93642902
7	MP0003880_abnormal_central_pattern	2.48413619
8	MP0002234_abnormal_pharynx_morphology	2.42586268
9	MP0003283_abnormal_digestive_organ	2.41209633
10	MP0005253_abnormal_eye_physiology	2.27947964
11	MP0005360_urolithiasis	2.26551899
12	MP0008058_abnormal_DNA_repair	2.24650640
13	MP0009046_muscle_twitch	2.20538683
14	MP0005083_abnormal_biliary_tract	2.18591516
15	MP0002736_abnormal_nociception_after	2.17902395
16	MP0001968_abnormal_touch/_nociception	2.06262426
17	MP0000383_abnormal_hair_follicle	2.05631982
18	MP0006072_abnormal_retinal_apoptosis	2.04658956
19	MP0005551_abnormal_eye_electrophysiolog	2.03269016
20	MP0003011_delayed_dark_adaptation	2.01796974
21	MP0003183_abnormal_peptide_metabolism	1.98698735
22	MP0001984_abnormal_olfaction	1.93304812
23	MP0000427_abnormal_hair_cycle	1.91211246
24	MP0008877_abnormal_DNA_methylation	1.87215794
25	MP0001501_abnormal_sleep_pattern	1.86475776
26	MP0008775_abnormal_heart_ventricle	1.82904320
27	MP0004270_analgesia	1.82787099
28	MP0010678_abnormal_skin_adnexa	1.77688951
29	MP0004084_abnormal_cardiac_muscle	1.74884884
30	MP0009745_abnormal_behavioral_response	1.74342383
31	MP0005084_abnormal_gallbladder_morpholo	1.71574550
32	MP0002272_abnormal_nervous_system	1.66309293
33	MP0005379_endocrine/exocrine_gland_phen	1.57396221
34	MP0003195_calcinosis	1.54668348
35	MP0006035_abnormal_mitochondrial_morpho	1.51885557
36	MP0008872_abnormal_physiological_respon	1.50721679
37	MP0001986_abnormal_taste_sensitivity	1.49095211
38	MP0004859_abnormal_synaptic_plasticity	1.45850034
39	MP0002163_abnormal_gland_morphology	1.41588208
40	MP0005085_abnormal_gallbladder_physiolo	1.41438028
41	MP0002064_seizures	1.41293921
42	MP0002160_abnormal_reproductive_system	1.40447289
43	MP0001764_abnormal_homeostasis	1.39356183
44	MP0006276_abnormal_autonomic_nervous	1.35933290
45	MP0009053_abnormal_anal_canal	1.33563432
46	MP0002095_abnormal_skin_pigmentation	1.32889212
47	MP0004145_abnormal_muscle_electrophysio	1.29978436
48	MP0005171_absent_coat_pigmentation	1.27611074
49	MP0005075_abnormal_melanosome_morpholog	1.25706532
50	MP0002090_abnormal_vision	1.19839701
51	MP0002067_abnormal_sensory_capabilities	1.19153177
52	MP0005365_abnormal_bile_salt	1.18421036
53	MP0004215_abnormal_myocardial_fiber	1.18032039
54	MP0003635_abnormal_synaptic_transmissio	1.16673298
55	MP0002572_abnormal_emotion/affect_behav	1.16334677
56	MP0001486_abnormal_startle_reflex	1.15657119
57	MP0005174_abnormal_tail_pigmentation	1.14328027
58	MP0002735_abnormal_chemical_nociception	1.12244610
59	MP0004924_abnormal_behavior	1.05273259
60	MP0005386_behavior/neurological_phenoty	1.05273259
61	MP0002938_white_spotting	1.00449600
62	MP0005367_renal/urinary_system_phenotyp	1.00407867
63	MP0000516_abnormal_urinary_system	1.00407867
64	MP0000371_diluted_coat_color	0.98517220
65	MP0005220_abnormal_exocrine_pancreas	0.97493630
66	MP0000015_abnormal_ear_pigmentation	0.97065281
67	MP0003806_abnormal_nucleotide_metabolis	0.96869921
68	MP0002229_neurodegeneration	0.96806717
69	MP0003136_yellow_coat_color	0.96617587
70	MP0005408_hypopigmentation	0.96477482
71	MP0006082_CNS_inflammation	0.95985606
72	MP0005167_abnormal_blood-brain_barrier	0.95618794
73	MP0003879_abnormal_hair_cell	0.92535219
74	MP0005195_abnormal_posterior_eye	0.91235501
75	MP0002282_abnormal_trachea_morphology	0.89393855
76	MP0000538_abnormal_urinary_bladder	0.89036303
77	MP0004036_abnormal_muscle_relaxation	0.87729659
78	MP0001529_abnormal_vocalization	0.87654117
79	MP0003787_abnormal_imprinting	0.87544954
80	MP0004142_abnormal_muscle_tone	0.86904800
81	MP0006036_abnormal_mitochondrial_physio	0.86486391
82	MP0001970_abnormal_pain_threshold	0.84964091
83	MP0002063_abnormal_learning/memory/cond	0.84635503
84	MP0004043_abnormal_pH_regulation	0.81906180
85	MP0005391_vision/eye_phenotype	0.81774734
86	MP0005646_abnormal_pituitary_gland	0.81522573
87	MP0002557_abnormal_social/conspecific_i	0.79151980
88	MP0009780_abnormal_chondrocyte_physiolo	0.75643857
89	MP0003646_muscle_fatigue	0.75610646
90	MP0005645_abnormal_hypothalamus_physiol	0.73315880
91	MP0001905_abnormal_dopamine_level	0.72483289
92	MP0001324_abnormal_eye_pigmentation	0.72126896
93	MP0005248_abnormal_Harderian_gland	0.68329737
94	MP0000465_gastrointestinal_hemorrhage	0.66614435
95	MP0001756_abnormal_urination	0.66186096
96	MP0003567_abnormal_fetal_cardiomyocyte	0.66166947
97	MP0002752_abnormal_somatic_nervous	0.65339916
98	MP0002882_abnormal_neuron_morphology	0.64821620
99	MP0000358_abnormal_cell_content/	0.64248603
100	MP0000647_abnormal_sebaceous_gland	0.63634314

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Renal cortical cysts (HP:0000803)	4.17279652
2	Abnormality of macular pigmentation (HP:0008002)	4.11794810
3	Focal motor seizures (HP:0011153)	3.67150712
4	Horizontal nystagmus (HP:0000666)	3.62875560
5	Bilateral microphthalmos (HP:0007633)	3.47394808
6	Abnormality of the renal cortex (HP:0011035)	3.17916316
7	Molar tooth sign on MRI (HP:0002419)	3.07629575
8	Abnormality of midbrain morphology (HP:0002418)	3.07629575
9	Intestinal atresia (HP:0011100)	3.01643865
10	Atonic seizures (HP:0010819)	2.89945265
11	Hyperventilation (HP:0002883)	2.86980620
12	Pancreatic cysts (HP:0001737)	2.83845324
13	Abolished electroretinogram (ERG) (HP:0000550)	2.79465684
14	3-Methylglutaconic aciduria (HP:0003535)	2.79238206
15	Bifid tongue (HP:0010297)	2.71186407
16	Type 2 muscle fiber atrophy (HP:0003554)	2.71026790
17	Fibular aplasia (HP:0002990)	2.64342054
18	Gaze-evoked nystagmus (HP:0000640)	2.61121230
19	Abnormality of the fovea (HP:0000493)	2.60163991
20	Febrile seizures (HP:0002373)	2.59175515
21	Abnormal auditory evoked potentials (HP:0006958)	2.58602898
22	Central scotoma (HP:0000603)	2.53637724
23	Medial flaring of the eyebrow (HP:0010747)	2.50126130
24	Nephronophthisis (HP:0000090)	2.48327180
25	Nephrogenic diabetes insipidus (HP:0009806)	2.47071384
26	Ependymoma (HP:0002888)	2.46940495
27	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.45028811
28	Hypoplasia of the fovea (HP:0007750)	2.45028811
29	Progressive macrocephaly (HP:0004481)	2.44247211
30	Absent speech (HP:0001344)	2.41981047
31	Pancreatic fibrosis (HP:0100732)	2.41253545
32	Cerebellar dysplasia (HP:0007033)	2.38362387
33	Focal seizures (HP:0007359)	2.35866647
34	Increased CSF lactate (HP:0002490)	2.33744346
35	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.32481721
36	True hermaphroditism (HP:0010459)	2.30804640
37	Absent eyebrow (HP:0002223)	2.30213339
38	Hip dysplasia (HP:0001385)	2.29087300
39	Acute necrotizing encephalopathy (HP:0006965)	2.25327785
40	Bony spicule pigmentary retinopathy (HP:0007737)	2.24467287
41	Anophthalmia (HP:0000528)	2.22750346
42	Fair hair (HP:0002286)	2.20676754
43	Astrocytoma (HP:0009592)	2.18439307
44	Abnormality of the astrocytes (HP:0100707)	2.18439307
45	Glioma (HP:0009733)	2.18213143
46	Pendular nystagmus (HP:0012043)	2.16960119
47	Hemiparesis (HP:0001269)	2.16431645
48	Methylmalonic aciduria (HP:0012120)	2.15260297
49	Epileptic encephalopathy (HP:0200134)	2.13584002
50	Gonadotropin excess (HP:0000837)	2.11876077
51	Acute encephalopathy (HP:0006846)	2.11661535
52	Dialeptic seizures (HP:0011146)	2.11320408
53	Severe visual impairment (HP:0001141)	2.07818438
54	Broad-based gait (HP:0002136)	2.06902230
55	Congenital stationary night blindness (HP:0007642)	2.06886992
56	Myokymia (HP:0002411)	2.06202892
57	Abnormality of the renal medulla (HP:0100957)	2.04437292
58	Type II lissencephaly (HP:0007260)	2.04429740
59	Generalized hypopigmentation of hair (HP:0011358)	2.04404794
60	Attenuation of retinal blood vessels (HP:0007843)	2.04137712
61	Neoplasm of the heart (HP:0100544)	2.02516975
62	Gait imbalance (HP:0002141)	2.01502479
63	Anterior segment dysgenesis (HP:0007700)	2.00537066
64	Scotoma (HP:0000575)	2.00293752
65	Cutaneous melanoma (HP:0012056)	1.98979756
66	Hypopigmentation of the fundus (HP:0007894)	1.97836700
67	Decreased muscle mass (HP:0003199)	1.97303307
68	Growth hormone deficiency (HP:0000824)	1.96697396
69	Lissencephaly (HP:0001339)	1.96144658
70	Abnormal mitochondria in muscle tissue (HP:0008316)	1.95483734
71	Mitochondrial inheritance (HP:0001427)	1.94390854
72	Azoospermia (HP:0000027)	1.93928754
73	Muscle fiber atrophy (HP:0100295)	1.93171960
74	Constricted visual fields (HP:0001133)	1.92077486
75	Oligodactyly (hands) (HP:0001180)	1.90755981
76	Ketoacidosis (HP:0001993)	1.90282008
77	Inability to walk (HP:0002540)	1.89603404
78	Carpal bone hypoplasia (HP:0001498)	1.87937734
79	Retinal dysplasia (HP:0007973)	1.87442782
80	Astigmatism (HP:0000483)	1.86627841
81	Clitoromegaly (HP:0000057)	1.85597631
82	Megalencephaly (HP:0001355)	1.85478773
83	Breast carcinoma (HP:0003002)	1.84954046
84	Volvulus (HP:0002580)	1.84949563
85	Genital tract atresia (HP:0001827)	1.84639145
86	Tented upper lip vermilion (HP:0010804)	1.84619104
87	Amyotrophic lateral sclerosis (HP:0007354)	1.84531451
88	Vaginal atresia (HP:0000148)	1.84112259
89	Abnormal hair whorl (HP:0010721)	1.84019630
90	Congenital primary aphakia (HP:0007707)	1.82774072
91	Neuroendocrine neoplasm (HP:0100634)	1.82220174
92	Long clavicles (HP:0000890)	1.81371754
93	Short tibia (HP:0005736)	1.79005748
94	Dysdiadochokinesis (HP:0002075)	1.76408066
95	Increased density of long bones (HP:0006392)	1.75765034
96	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.72842855
97	Progressive cerebellar ataxia (HP:0002073)	1.72654432
98	Pheochromocytoma (HP:0002666)	1.72620583
99	Morphological abnormality of the middle ear (HP:0008609)	1.71272156
100	Aplasia/Hypoplasia of the macula (HP:0008059)	1.70978179

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	6.04994379
2	MUSK	5.12389717
3	MARK1	3.31120238
4	NTRK3	2.91362122
5	BCR	2.61324164
6	SRPK1	2.38641803
7	LATS1	2.37422904
8	TRIM28	2.34969043
9	NME1	1.93818562
10	PIK3CA	1.91271470
11	PKN1	1.90885502
12	NUAK1	1.87210228
13	MAPK13	1.77015201
14	FER	1.61127090
15	BMPR1B	1.57754280
16	MAP4K2	1.57480783
17	CAMKK2	1.52221630
18	INSRR	1.47553884
19	ZAK	1.43391111
20	EPHA3	1.37811990
21	CSNK1G2	1.37447561
22	PAK3	1.36649937
23	DYRK3	1.35918671
24	ERBB4	1.32118162
25	ADRBK2	1.31322856
26	ERBB3	1.30300491
27	OXSR1	1.25446266
28	MAP3K4	1.25134726
29	MAP2K6	1.23445670
30	CASK	1.19970003
31	PINK1	1.19283329
32	SIK3	1.17445024
33	DYRK2	1.15379372
34	CCNB1	1.13461260
35	PBK	1.07464628
36	CAMK1	1.07013996
37	MAP2K7	1.06734184
38	STK16	1.06183929
39	PIK3CG	1.04249305
40	PRKCE	1.03369728
41	CSNK1G3	1.01471673
42	MINK1	1.00895443
43	WNK3	1.00559144
44	EIF2AK3	0.99508376
45	IRAK1	0.97550750
46	EIF2AK1	0.95365671
47	PNCK	0.94926229
48	ACVR1B	0.90338442
49	MARK3	0.86444946
50	PLK2	0.86272113
51	CAMK2A	0.84946036
52	CDK3	0.80054326
53	CSNK1G1	0.78586353
54	STK3	0.77349372
55	MAP3K5	0.73857980
56	AKT2	0.73597697
57	PRKCG	0.73158574
58	ERBB2	0.73081939
59	BMPR2	0.72216022
60	CSNK1A1L	0.68203712
61	SIK2	0.67312796
62	FLT3	0.66530912
63	CAMK4	0.64207758
64	TLK1	0.61678319
65	LIMK1	0.61552949
66	IKBKB	0.57583893
67	RPS6KA4	0.57019977
68	MAPKAPK3	0.56440357
69	PLK3	0.55999927
70	EPHA4	0.53107171
71	GRK5	0.52636527
72	PTK2B	0.52037202
73	MET	0.51582006
74	RPS6KA5	0.49449515
75	DAPK1	0.49424972
76	PIM2	0.48333739
77	ABL1	0.45986854
78	MAP3K12	0.44647061
79	ADRBK1	0.44615636
80	MST1R	0.41474519
81	CSNK1D	0.41146233
82	ATR	0.39529435
83	DYRK1A	0.39432717
84	STK39	0.38413076
85	NEK9	0.36879776
86	ATM	0.36663432
87	ROCK1	0.35739567
88	CDK5	0.34625852
89	PHKG1	0.33997964
90	PHKG2	0.33997964
91	KSR1	0.33615502
92	OBSCN	0.32811822
93	CHUK	0.31564613
94	PRKACA	0.30995484
95	VRK1	0.30861363
96	PRKCZ	0.29817336
97	CAMK2G	0.29177672
98	PRKCB	0.28766454
99	DAPK2	0.28147715
100	MAP3K2	0.28057504

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	3.71551119
2	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.07126745
3	Nicotine addiction_Homo sapiens_hsa05033	3.06375378
4	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.66184550
5	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.63146495
6	Butanoate metabolism_Homo sapiens_hsa00650	2.57600279
7	Asthma_Homo sapiens_hsa05310	2.22994148
8	Phototransduction_Homo sapiens_hsa04744	2.19224871
9	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	2.13932398
10	Selenocompound metabolism_Homo sapiens_hsa00450	2.12476827
11	Parkinsons disease_Homo sapiens_hsa05012	2.09755883
12	Collecting duct acid secretion_Homo sapiens_hsa04966	2.08690225
13	Oxidative phosphorylation_Homo sapiens_hsa00190	2.06210609
14	RNA polymerase_Homo sapiens_hsa03020	2.04057372
15	Protein export_Homo sapiens_hsa03060	1.97828144
16	Taste transduction_Homo sapiens_hsa04742	1.93853456
17	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.83260046
18	Olfactory transduction_Homo sapiens_hsa04740	1.82375065
19	Homologous recombination_Homo sapiens_hsa03440	1.79805169
20	Non-homologous end-joining_Homo sapiens_hsa03450	1.77794938
21	Fanconi anemia pathway_Homo sapiens_hsa03460	1.67976378
22	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.57990108
23	One carbon pool by folate_Homo sapiens_hsa00670	1.56577791
24	RNA degradation_Homo sapiens_hsa03018	1.42744274
25	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.37474607
26	Morphine addiction_Homo sapiens_hsa05032	1.34863293
27	Nitrogen metabolism_Homo sapiens_hsa00910	1.34554842
28	Huntingtons disease_Homo sapiens_hsa05016	1.34257742
29	Propanoate metabolism_Homo sapiens_hsa00640	1.32005800
30	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.30619665
31	Circadian rhythm_Homo sapiens_hsa04710	1.29605210
32	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.24586840
33	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.23233091
34	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.19744478
35	GABAergic synapse_Homo sapiens_hsa04727	1.19692060
36	ABC transporters_Homo sapiens_hsa02010	1.13788755
37	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.13069012
38	Circadian entrainment_Homo sapiens_hsa04713	1.09878707
39	Fatty acid elongation_Homo sapiens_hsa00062	1.08770139
40	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.04501933
41	Basal transcription factors_Homo sapiens_hsa03022	1.03509793
42	Peroxisome_Homo sapiens_hsa04146	1.02311199
43	Alzheimers disease_Homo sapiens_hsa05010	1.00674086
44	Proteasome_Homo sapiens_hsa03050	0.99647721
45	Cocaine addiction_Homo sapiens_hsa05030	0.99498724
46	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.97296955
47	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.94499233
48	Glycerolipid metabolism_Homo sapiens_hsa00561	0.91253426
49	Amphetamine addiction_Homo sapiens_hsa05031	0.90666363
50	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.89983368
51	Oocyte meiosis_Homo sapiens_hsa04114	0.88289746
52	Glutamatergic synapse_Homo sapiens_hsa04724	0.86536960
53	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.84267579
54	Linoleic acid metabolism_Homo sapiens_hsa00591	0.83315085
55	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.82514570
56	Caffeine metabolism_Homo sapiens_hsa00232	0.81396003
57	Dopaminergic synapse_Homo sapiens_hsa04728	0.80285716
58	Calcium signaling pathway_Homo sapiens_hsa04020	0.78373938
59	Retinol metabolism_Homo sapiens_hsa00830	0.78015664
60	Tryptophan metabolism_Homo sapiens_hsa00380	0.74114892
61	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.73339520
62	Serotonergic synapse_Homo sapiens_hsa04726	0.68770993
63	Sphingolipid metabolism_Homo sapiens_hsa00600	0.68382340
64	Regulation of autophagy_Homo sapiens_hsa04140	0.68204298
65	beta-Alanine metabolism_Homo sapiens_hsa00410	0.66874846
66	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.65595151
67	Salivary secretion_Homo sapiens_hsa04970	0.65383687
68	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.64017095
69	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.62553869
70	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.61857090
71	Long-term depression_Homo sapiens_hsa04730	0.58766613
72	Allograft rejection_Homo sapiens_hsa05330	0.57995769
73	Chemical carcinogenesis_Homo sapiens_hsa05204	0.55667667
74	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.55271966
75	Metabolic pathways_Homo sapiens_hsa01100	0.54743196
76	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.54709023
77	Insulin secretion_Homo sapiens_hsa04911	0.52872730
78	Cardiac muscle contraction_Homo sapiens_hsa04260	0.52393643
79	Purine metabolism_Homo sapiens_hsa00230	0.50421675
80	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.46051158
81	Ether lipid metabolism_Homo sapiens_hsa00565	0.45820581
82	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.44459135
83	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.44357746
84	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.44120078
85	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.42993087
86	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.42195797
87	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.41395412
88	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.39768972
89	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.39079033
90	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.38939903
91	Alcoholism_Homo sapiens_hsa05034	0.36957084
92	Lysosome_Homo sapiens_hsa04142	0.36633944
93	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.36223106
94	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.35947216
95	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.35798897
96	Histidine metabolism_Homo sapiens_hsa00340	0.33464249
97	Type I diabetes mellitus_Homo sapiens_hsa04940	0.32270138
98	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.32016586
99	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.31092923
100	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.30144936

CXXC1P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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