CXXC5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a retinoid-inducible nuclear protein containing a CXXC-type zinc finger motif. The encoded protein is involved in myelopoiesis, is required for DNA damage-induced p53 activation, regulates the differentiation of C2C12 myoblasts into myocytes, and negatively regulates cutaneous wound healing. Several transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.55596260
2L-phenylalanine catabolic process (GO:0006559)5.55596260
3axon ensheathment in central nervous system (GO:0032291)5.52728355
4central nervous system myelination (GO:0022010)5.52728355
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.42076042
6L-phenylalanine metabolic process (GO:0006558)5.42076042
7synaptic vesicle docking involved in exocytosis (GO:0016081)4.42753963
8glutamate secretion (GO:0014047)4.20799913
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.06725738
10regulation of synaptic vesicle exocytosis (GO:2000300)4.02925437
11cellular potassium ion homeostasis (GO:0030007)4.00591465
12regulation of short-term neuronal synaptic plasticity (GO:0048172)3.99876866
13glyoxylate metabolic process (GO:0046487)3.89395840
14establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.88593321
15mitochondrion transport along microtubule (GO:0047497)3.88593321
16peptidyl-tyrosine autophosphorylation (GO:0038083)3.82464572
17myelin maintenance (GO:0043217)3.72743059
18sodium ion export (GO:0071436)3.72623995
19aromatic amino acid family catabolic process (GO:0009074)3.57018951
20G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.55510906
21regulation of glutamate receptor signaling pathway (GO:1900449)3.51688713
22postsynaptic membrane organization (GO:0001941)3.43087869
23drug transmembrane transport (GO:0006855)3.40197925
24regulation of synaptic vesicle transport (GO:1902803)3.40133058
25dopamine receptor signaling pathway (GO:0007212)3.38093385
26neuromuscular process controlling balance (GO:0050885)3.36072649
27membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.35689996
28adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.35509767
29cell migration in hindbrain (GO:0021535)3.33756390
30regulation of neuronal synaptic plasticity (GO:0048168)3.30239593
31positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.30055553
32locomotory exploration behavior (GO:0035641)3.29137368
33neurotransmitter secretion (GO:0007269)3.27518781
34myelination (GO:0042552)3.24499901
35axon ensheathment (GO:0008366)3.23389307
36ensheathment of neurons (GO:0007272)3.23389307
37aspartate family amino acid catabolic process (GO:0009068)3.21710989
38positive regulation of synapse maturation (GO:0090129)3.19319369
39alpha-linolenic acid metabolic process (GO:0036109)3.14523918
40vocalization behavior (GO:0071625)3.13428555
41positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.13382057
42dendritic spine morphogenesis (GO:0060997)3.12511099
43regulation of ARF protein signal transduction (GO:0032012)3.12167179
44response to parathyroid hormone (GO:0071107)3.09826304
45cell-cell junction maintenance (GO:0045217)3.05852625
46L-amino acid import (GO:0043092)3.03688458
47regulation of female receptivity (GO:0045924)3.02583867
48female mating behavior (GO:0060180)2.99978819
49exocrine pancreas development (GO:0031017)2.98332029
50fatty acid elongation (GO:0030497)2.98240996
51synaptic vesicle maturation (GO:0016188)2.93997418
52potassium ion homeostasis (GO:0055075)2.93779147
53response to mercury ion (GO:0046689)2.91718379
54layer formation in cerebral cortex (GO:0021819)2.91185594
55positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.88535004
56cellular modified amino acid catabolic process (GO:0042219)2.86385172
57dicarboxylic acid catabolic process (GO:0043649)2.85792948
58negative regulation of erythrocyte differentiation (GO:0045647)2.85188292
59phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.83159575
60regulation of long-term neuronal synaptic plasticity (GO:0048169)2.82343345
61cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.80894811
62regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.80723007
63axonal fasciculation (GO:0007413)2.79378964
64short-chain fatty acid metabolic process (GO:0046459)2.78598077
65ionotropic glutamate receptor signaling pathway (GO:0035235)2.77013055
66very long-chain fatty acid metabolic process (GO:0000038)2.76266219
67cysteine metabolic process (GO:0006534)2.75414508
68amino acid import (GO:0043090)2.73461250
69regulation of autophagic vacuole assembly (GO:2000785)2.73149855
70endocrine pancreas development (GO:0031018)2.72436742
71tricarboxylic acid metabolic process (GO:0072350)2.71350108
72metanephric nephron epithelium development (GO:0072243)2.71169583
73apical protein localization (GO:0045176)2.70599252
74glutamate metabolic process (GO:0006536)2.70228586
75activation of protein kinase A activity (GO:0034199)2.68791740
76regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.68610690
77synaptic transmission, glutamatergic (GO:0035249)2.68556961
78lysine catabolic process (GO:0006554)2.68342407
79lysine metabolic process (GO:0006553)2.68342407
80exploration behavior (GO:0035640)2.66127871
81positive regulation of dendritic spine development (GO:0060999)2.65951208
82negative regulation of cell size (GO:0045792)2.64914239
83negative regulation of catenin import into nucleus (GO:0035414)2.64643169
84positive regulation of neurotransmitter transport (GO:0051590)2.63252743
85regulation of synapse structural plasticity (GO:0051823)2.62963164
86neuron recognition (GO:0008038)2.62473406
87bile acid biosynthetic process (GO:0006699)2.61810173
88L-serine metabolic process (GO:0006563)2.59984793
89metanephric nephron tubule development (GO:0072234)2.59866912
90metanephric tubule development (GO:0072170)2.59866912
91neuron projection regeneration (GO:0031102)2.59108605
92regulation of cholesterol homeostasis (GO:2000188)2.58873455
93coenzyme catabolic process (GO:0009109)2.58743163
94regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.58588336
95asymmetric protein localization (GO:0008105)2.58552783
96regulation of synaptic plasticity (GO:0048167)2.58037165
97camera-type eye morphogenesis (GO:0048593)2.57043260
98cell communication by electrical coupling (GO:0010644)2.56863132
99serine family amino acid biosynthetic process (GO:0009070)2.56241572
100creatine metabolic process (GO:0006600)2.56065589
101synaptic vesicle endocytosis (GO:0048488)2.55882319
102sulfur amino acid catabolic process (GO:0000098)2.54196455
103mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.53845685
104phosphate ion transport (GO:0006817)2.53836345
105regulation of neurotransmitter levels (GO:0001505)2.53128000
106axon extension (GO:0048675)2.51559916
107cellular amino acid catabolic process (GO:0009063)2.50914981
108regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.50128277
109neurotransmitter transport (GO:0006836)2.49994402
110alpha-amino acid catabolic process (GO:1901606)2.49047049
111positive regulation of neurotransmitter secretion (GO:0001956)2.48582886
112neuronal action potential propagation (GO:0019227)2.48096049
113response to pheromone (GO:0019236)2.47919257
114barbed-end actin filament capping (GO:0051016)2.46882214
115positive regulation of axon extension (GO:0045773)2.46016719
116metanephric epithelium development (GO:0072207)2.45930402
117cytoskeletal anchoring at plasma membrane (GO:0007016)2.45187374
118Golgi transport vesicle coating (GO:0048200)2.41718873
119COPI coating of Golgi vesicle (GO:0048205)2.41718873
120transmission of nerve impulse (GO:0019226)2.41499693
121regulation of cholesterol biosynthetic process (GO:0045540)2.41381987
122regulation of neurotransmitter secretion (GO:0046928)2.41169058
123response to methylmercury (GO:0051597)2.40986618
124neuromuscular synaptic transmission (GO:0007274)2.40600779
125aromatic amino acid family metabolic process (GO:0009072)2.40403927
126protein import into peroxisome matrix (GO:0016558)2.40263544
127drug transport (GO:0015893)2.40005981
128viral transcription (GO:0019083)2.38458186
129dendritic spine organization (GO:0097061)2.38367628
130positive regulation of dendrite development (GO:1900006)2.38070416
131cell volume homeostasis (GO:0006884)2.38044366
132positive regulation of nitric-oxide synthase activity (GO:0051000)2.37233130
133hyperosmotic salinity response (GO:0042538)2.36872726
134cerebellar granule cell differentiation (GO:0021707)2.36625986
135protein retention in ER lumen (GO:0006621)2.35676516
136adenosine receptor signaling pathway (GO:0001973)2.34741018
137Peyers patch development (GO:0048541)2.34678581
138mucosal-associated lymphoid tissue development (GO:0048537)2.34678581
139neuron cell-cell adhesion (GO:0007158)2.34180730
140positive regulation of cellular amine metabolic process (GO:0033240)2.34046734
141glandular epithelial cell differentiation (GO:0002067)2.31649685
142neuromuscular process controlling posture (GO:0050884)2.31431951
143regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.31228402
144cell differentiation in hindbrain (GO:0021533)2.30931102
145negative regulation of axonogenesis (GO:0050771)2.30302758
146L-serine transport (GO:0015825)2.30156384
147coenzyme A metabolic process (GO:0015936)2.29845883
148glutamine family amino acid biosynthetic process (GO:0009084)2.29647353
149serine family amino acid metabolic process (GO:0009069)2.28584897
150tyrosine metabolic process (GO:0006570)2.26585126
151planar cell polarity pathway involved in neural tube closure (GO:0090179)2.25765117
152polarized epithelial cell differentiation (GO:0030859)2.24548492
153C4-dicarboxylate transport (GO:0015740)2.23007063
154detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.22194559
155detection of temperature stimulus involved in sensory perception (GO:0050961)2.22194559
156cellular ketone body metabolic process (GO:0046950)2.21804934
157primitive streak formation (GO:0090009)2.21414015
158positive regulation of insulin secretion (GO:0032024)2.20392711
159bile acid metabolic process (GO:0008206)2.20136928
160branched-chain amino acid metabolic process (GO:0009081)2.19673690
161fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.19150920
162neuronal ion channel clustering (GO:0045161)2.18317287
163potassium ion import (GO:0010107)2.16304687
164cranial nerve development (GO:0021545)2.16245818
165branched-chain amino acid catabolic process (GO:0009083)2.15689912
166valine metabolic process (GO:0006573)2.15021796
167protein-DNA complex disassembly (GO:0032986)2.14323203
168nucleosome disassembly (GO:0006337)2.14323203
169establishment of mitochondrion localization (GO:0051654)2.14227536
170lens fiber cell development (GO:0070307)2.13908367
171peroxisome fission (GO:0016559)2.13124690
172synaptic vesicle exocytosis (GO:0016079)2.13106106
173kynurenine metabolic process (GO:0070189)2.12983099
174protein maturation by protein folding (GO:0022417)2.12829074
175nephron tubule formation (GO:0072079)2.12794520
176negative regulation of fibrinolysis (GO:0051918)2.12773240
177maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.12424009
1784-hydroxyproline metabolic process (GO:0019471)2.08111435
179glycine metabolic process (GO:0006544)2.07690654
180negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.07057136
181cerebellar Purkinje cell layer development (GO:0021680)2.07040204
182organic acid catabolic process (GO:0016054)2.06871682
183carboxylic acid catabolic process (GO:0046395)2.06871682

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.01012638
2EZH2_22144423_ChIP-Seq_EOC_Human3.44305350
3THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.02662445
4* RXR_22158963_ChIP-Seq_LIVER_Mouse2.55195363
5ESR2_21235772_ChIP-Seq_MCF-7_Human2.43298824
6ZFP281_18757296_ChIP-ChIP_E14_Mouse2.32080055
7DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.11139943
8EZH2_27294783_Chip-Seq_ESCs_Mouse2.09336517
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.05992356
10* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.04800456
11SUZ12_27294783_Chip-Seq_ESCs_Mouse2.03552823
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.02290887
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.02290887
14* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.00804375
15ERG_21242973_ChIP-ChIP_JURKAT_Human1.95298990
16OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.94492876
17JARID2_20064375_ChIP-Seq_MESCs_Mouse1.92505062
18MTF2_20144788_ChIP-Seq_MESCs_Mouse1.91093505
19* LXR_22292898_ChIP-Seq_THP-1_Human1.90940244
20RARG_19884340_ChIP-ChIP_MEFs_Mouse1.89151050
21SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.88520779
22SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.87791582
23* SCL_19346495_ChIP-Seq_HPC-7_Human1.87675257
24RARB_27405468_Chip-Seq_BRAIN_Mouse1.86068828
25ESR1_15608294_ChIP-ChIP_MCF-7_Human1.85656142
26EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.79541164
27DNAJC2_21179169_ChIP-ChIP_NT2_Human1.77219890
28LXR_22158963_ChIP-Seq_LIVER_Mouse1.77016121
29SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.76816922
30SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.76618978
31SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.76602572
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.75181174
33EZH2_27304074_Chip-Seq_ESCs_Mouse1.75058575
34DROSHA_22980978_ChIP-Seq_HELA_Human1.75050121
35* RACK7_27058665_Chip-Seq_MCF-7_Human1.70819943
36PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.66287432
37* REST_18959480_ChIP-ChIP_MESCs_Mouse1.66148495
38MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.65803843
39PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.65492159
40NFIB_24661679_ChIP-Seq_LUNG_Mouse1.60307059
41* MYC_22102868_ChIP-Seq_BL_Human1.59527019
42ESR1_21235772_ChIP-Seq_MCF-7_Human1.59477447
43SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.59070810
44EED_16625203_ChIP-ChIP_MESCs_Mouse1.56868083
45FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.56186763
46* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.55614261
47RNF2_27304074_Chip-Seq_ESCs_Mouse1.53818086
48RING1B_27294783_Chip-Seq_ESCs_Mouse1.51447482
49* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.50085004
50EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.46480957
51* REST_21632747_ChIP-Seq_MESCs_Mouse1.45822570
52* KDM2B_26808549_Chip-Seq_DND41_Human1.45389588
53CTCF_27219007_Chip-Seq_Bcells_Human1.43309792
54* KDM2B_26808549_Chip-Seq_K562_Human1.42284778
55RING1B_27294783_Chip-Seq_NPCs_Mouse1.36735180
56ELK3_25401928_ChIP-Seq_HUVEC_Human1.35325663
57RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.35256427
58ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.34996132
59* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.34861604
60* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.34318766
61MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.33667311
62* TCF7_22412390_ChIP-Seq_EML_Mouse1.32167907
63FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.32053491
64ZNF274_21170338_ChIP-Seq_K562_Hela1.31913860
65VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.30872994
66CREB1_26743006_Chip-Seq_LNCaP_Human1.29390276
67TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28595685
68* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.27881157
69TRIM28_21343339_ChIP-Seq_HEK293_Human1.25116036
70SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.24898905
71SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.24524496
72UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.24089961
73PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.23418668
74SA1_27219007_Chip-Seq_ERYTHROID_Human1.23191351
75CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.23008614
76ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.22152510
77PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.18199811
78TP53_20018659_ChIP-ChIP_R1E_Mouse1.16070060
79IKZF1_21737484_ChIP-ChIP_HCT116_Human1.15352032
80* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.14861572
81CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.14769510
82* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.14548464
83SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.13891649
84* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.13095551
85ELF1_20517297_ChIP-Seq_JURKAT_Human1.12523842
86* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12489022
87TET1_21451524_ChIP-Seq_MESCs_Mouse1.12030358
88* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11282067
89TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.10445392
90* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.09697193
91P68_20966046_ChIP-Seq_HELA_Human1.08796918
92SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07742402
93* RUNX1_27514584_Chip-Seq_MCF-7_Human1.06741053
94CTCF_18555785_ChIP-Seq_MESCs_Mouse1.06436798
95ZNF263_19887448_ChIP-Seq_K562_Human1.06283408
96ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.05459350
97CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.05331395
98NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.04787970
99* KDM2B_26808549_Chip-Seq_JURKAT_Human1.04552899
100STAT6_21828071_ChIP-Seq_BEAS2B_Human1.04070123
101FOXP1_21924763_ChIP-Seq_HESCs_Human1.04033608
102SOX3_22085726_ChIP-Seq_NPCs_Mouse1.03925922
103* VDR_21846776_ChIP-Seq_THP-1_Human1.02153157
104TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.02119290
105* CTCF_20526341_ChIP-Seq_ESCs_Human1.01583059
106* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.99130121
107SA1_27219007_Chip-Seq_Bcells_Human0.97930308
108ESR1_20079471_ChIP-ChIP_T-47D_Human0.97757151
109* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.97699963
110RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.97648279
111* TET1_21490601_ChIP-Seq_MESCs_Mouse0.97498218
112ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.96654848
113SRY_22984422_ChIP-ChIP_TESTIS_Rat0.95543330
114* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.94912501
115* VDR_24763502_ChIP-Seq_THP-1_Human0.94775324
116CTCF_21964334_ChIP-Seq_BJAB-B_Human0.93890014
117* OCT4_19829295_ChIP-Seq_ESCs_Human0.93872672
118SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.92627588
119* FOXA2_19822575_ChIP-Seq_HepG2_Human0.91822587
120CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.90586101
121FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.88931895
122PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.88841963
123NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.88833738
124* SMC4_20622854_ChIP-Seq_HELA_Human0.87133883
125GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.84199306
126* SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.83655159

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system3.47866224
2MP0009278_abnormal_bone_marrow3.05992582
3MP0004043_abnormal_pH_regulation3.01690820
4MP0005365_abnormal_bile_salt2.97024263
5MP0003123_paternal_imprinting2.90669505
6MP0003787_abnormal_imprinting2.79734670
7MP0005360_urolithiasis2.62744834
8MP0002822_catalepsy2.60807991
9MP0009780_abnormal_chondrocyte_physiolo2.56896344
10MP0005058_abnormal_lysosome_morphology2.48402183
11MP0004885_abnormal_endolymph2.36091853
12MP0003283_abnormal_digestive_organ2.30568563
13MP0005085_abnormal_gallbladder_physiolo2.24311192
14MP0002653_abnormal_ependyma_morphology2.21494898
15MP0009379_abnormal_foot_pigmentation2.21035068
16MP0005220_abnormal_exocrine_pancreas2.20495269
17MP0004270_analgesia2.07508060
18MP0001968_abnormal_touch/_nociception2.04731920
19MP0003195_calcinosis1.99694250
20MP0004859_abnormal_synaptic_plasticity1.99310003
21MP0008875_abnormal_xenobiotic_pharmacok1.99285267
22MP0003172_abnormal_lysosome_physiology1.96406212
23MP0000920_abnormal_myelination1.87474815
24MP0006072_abnormal_retinal_apoptosis1.82974200
25MP0003868_abnormal_feces_composition1.82348463
26MP0003880_abnormal_central_pattern1.81464324
27MP0004145_abnormal_muscle_electrophysio1.81211491
28MP0005332_abnormal_amino_acid1.78860657
29MP0002272_abnormal_nervous_system1.71447237
30MP0003635_abnormal_synaptic_transmissio1.70492240
31MP0001944_abnormal_pancreas_morphology1.69922049
32MP0002909_abnormal_adrenal_gland1.60978484
33MP0000955_abnormal_spinal_cord1.60456465
34MP0009384_cardiac_valve_regurgitation1.58621741
35MP0003329_amyloid_beta_deposits1.54984274
36MP0000678_abnormal_parathyroid_gland1.54099944
37MP0005083_abnormal_biliary_tract1.53915940
38MP0003705_abnormal_hypodermis_morpholog1.53460027
39MP0003252_abnormal_bile_duct1.50557663
40MP0002064_seizures1.50079078
41MP0002733_abnormal_thermal_nociception1.50065622
42MP0009046_muscle_twitch1.49820704
43MP0000604_amyloidosis1.48571770
44MP0001502_abnormal_circadian_rhythm1.44078707
45MP0001440_abnormal_grooming_behavior1.41730710
46MP0003122_maternal_imprinting1.41174115
47MP0002735_abnormal_chemical_nociception1.40793799
48MP0005397_hematopoietic_system_phenotyp1.40741291
49MP0001545_abnormal_hematopoietic_system1.40741291
50MP0004133_heterotaxia1.39888859
51MP0008569_lethality_at_weaning1.38123683
52MP0001666_abnormal_nutrient_absorption1.37982251
53MP0001970_abnormal_pain_threshold1.35797223
54MP0004142_abnormal_muscle_tone1.35782059
55MP0000534_abnormal_ureter_morphology1.30802099
56MP0000747_muscle_weakness1.27098173
57MP0000462_abnormal_digestive_system1.26784598
58MP0002736_abnormal_nociception_after1.25962476
59MP0003191_abnormal_cellular_cholesterol1.25258699
60MP0008961_abnormal_basal_metabolism1.24684955
61MP0005410_abnormal_fertilization1.23448937
62MP0005423_abnormal_somatic_nervous1.22989023
63MP0003075_altered_response_to1.22886467
64MP0004858_abnormal_nervous_system1.22225497
65MP0004233_abnormal_muscle_weight1.21430320
66MP0003806_abnormal_nucleotide_metabolis1.20765877
67MP0000631_abnormal_neuroendocrine_gland1.20727830
68MP0000751_myopathy1.20185712
69MP0003942_abnormal_urinary_system1.19335156
70MP0002184_abnormal_innervation1.18442543
71MP0010030_abnormal_orbit_morphology1.17883000
72MP0002229_neurodegeneration1.17140298
73MP0002089_abnormal_postnatal_growth/wei1.15099598
74MP0005551_abnormal_eye_electrophysiolog1.14574618
75MP0000778_abnormal_nervous_system1.14555477
76MP0009745_abnormal_behavioral_response1.13086839
77MP0002234_abnormal_pharynx_morphology1.12934408
78MP0001486_abnormal_startle_reflex1.12322246
79MP0004811_abnormal_neuron_physiology1.10280561
80MP0002693_abnormal_pancreas_physiology1.09890651
81MP0005646_abnormal_pituitary_gland1.08968260
82MP0000639_abnormal_adrenal_gland1.08816379
83MP0002882_abnormal_neuron_morphology1.08534578
84MP0006276_abnormal_autonomic_nervous1.04213827
85MP0003690_abnormal_glial_cell1.04081187
86MP0009840_abnormal_foam_cell1.03927055
87MP0002118_abnormal_lipid_homeostasis1.02573176
88MP0003119_abnormal_digestive_system1.02146849
89MP0001765_abnormal_ion_homeostasis1.02133866
90MP0001963_abnormal_hearing_physiology1.01547267
91MP0001348_abnormal_lacrimal_gland1.00662098
92MP0002557_abnormal_social/conspecific_i1.00540312
93MP0003121_genomic_imprinting1.00378044
94MP0005645_abnormal_hypothalamus_physiol0.99534547
95MP0002078_abnormal_glucose_homeostasis0.99057834
96MP0009643_abnormal_urine_homeostasis0.98556463
97MP0003183_abnormal_peptide_metabolism0.97400841
98MP0002066_abnormal_motor_capabilities/c0.97157007
99MP0002572_abnormal_emotion/affect_behav0.96705375
100MP0001905_abnormal_dopamine_level0.96679711
101MP0001664_abnormal_digestion0.96572962
102MP0006036_abnormal_mitochondrial_physio0.96199441
103MP0002152_abnormal_brain_morphology0.95781047
104MP0009672_abnormal_birth_weight0.95592372
105MP0000003_abnormal_adipose_tissue0.94759635
106MP0003279_aneurysm0.94630177
107MP0000013_abnormal_adipose_tissue0.94567029
108MP0002063_abnormal_learning/memory/cond0.93995567
109MP0002734_abnormal_mechanical_nocicepti0.92300972
110MP0002067_abnormal_sensory_capabilities0.92240230
111MP0002249_abnormal_larynx_morphology0.91976478
112MP0005409_darkened_coat_color0.91871014
113MP0000681_abnormal_thyroid_gland0.91830117
114MP0003634_abnormal_glial_cell0.91506852
115MP0010329_abnormal_lipoprotein_level0.90565817
116MP0005253_abnormal_eye_physiology0.90408003
117MP0005584_abnormal_enzyme/coenzyme_acti0.88043425
118MP0010368_abnormal_lymphatic_system0.87892132
119MP0001485_abnormal_pinna_reflex0.87654572
120MP0003632_abnormal_nervous_system0.87476311
121MP0000049_abnormal_middle_ear0.87014943
122MP0006292_abnormal_olfactory_placode0.85571551
123MP0004510_myositis0.85235699
124MP0002638_abnormal_pupillary_reflex0.83442301
125MP0002752_abnormal_somatic_nervous0.81840604
126MP0003633_abnormal_nervous_system0.80968005
127MP0003959_abnormal_lean_body0.80352542
128MP0002938_white_spotting0.78751587
129MP0003861_abnormal_nervous_system0.78105264
130MP0003631_nervous_system_phenotype0.76780510
131MP0003879_abnormal_hair_cell0.76316447
132MP0002928_abnormal_bile_duct0.74868494
133MP0004134_abnormal_chest_morphology0.74657497
134MP0000749_muscle_degeneration0.73453277
135MP0008874_decreased_physiological_sensi0.72681217
136MP0000759_abnormal_skeletal_muscle0.71085712
137MP0005535_abnormal_body_temperature0.70735967
138MP0001984_abnormal_olfaction0.70236402
139MP0000026_abnormal_inner_ear0.68027477
140MP0004924_abnormal_behavior0.67211853
141MP0005386_behavior/neurological_phenoty0.67211853
142MP0010386_abnormal_urinary_bladder0.64289650
143MP0002254_reproductive_system_inflammat0.63686686
144MP0001731_abnormal_postnatal_growth0.62994514
145MP0005499_abnormal_olfactory_system0.62799978
146MP0005394_taste/olfaction_phenotype0.62799978
147MP0005508_abnormal_skeleton_morphology0.62405592

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.65867536
2Hyperinsulinemic hypoglycemia (HP:0000825)3.71079207
3Ketosis (HP:0001946)3.68852182
4Hypokalemic alkalosis (HP:0001949)3.50185076
5Obstructive sleep apnea (HP:0002870)3.43765742
6Ketoacidosis (HP:0001993)3.38767493
7Increased circulating renin level (HP:0000848)3.37138629
8Hypoglycemic coma (HP:0001325)3.32431545
9Abnormality of endocrine pancreas physiology (HP:0012093)3.31711347
10Abnormality of the pancreatic islet cells (HP:0006476)3.31711347
11Hypoglycemic seizures (HP:0002173)3.22801905
12Late onset (HP:0003584)3.09729474
13Ankle clonus (HP:0011448)3.07581300
14Intrahepatic cholestasis (HP:0001406)3.07185296
15Focal motor seizures (HP:0011153)3.06926292
16Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.01738082
17Abnormality of binocular vision (HP:0011514)2.98444625
18Diplopia (HP:0000651)2.98444625
19Delayed CNS myelination (HP:0002188)2.94255513
20Deep venous thrombosis (HP:0002625)2.92781315
21J-shaped sella turcica (HP:0002680)2.91547584
22Distal lower limb muscle weakness (HP:0009053)2.84460901
23Hyperthyroidism (HP:0000836)2.82585887
24Focal seizures (HP:0007359)2.82442409
25Gout (HP:0001997)2.78062367
26Akinesia (HP:0002304)2.75275585
27Pancreatic islet-cell hyperplasia (HP:0004510)2.71882042
28Torticollis (HP:0000473)2.67104083
29Neurofibrillary tangles (HP:0002185)2.66154876
30Visual hallucinations (HP:0002367)2.65707454
31Fetal akinesia sequence (HP:0001989)2.65483541
32Dysostosis multiplex (HP:0000943)2.62696532
33Abnormal eating behavior (HP:0100738)2.57767535
34Increased cerebral lipofuscin (HP:0011813)2.51355611
35Hyperlipoproteinemia (HP:0010980)2.49293200
36Action tremor (HP:0002345)2.48870966
37Alkalosis (HP:0001948)2.42457181
38Annular pancreas (HP:0001734)2.42316403
39Symptomatic seizures (HP:0011145)2.38652944
40Mutism (HP:0002300)2.38529105
41Large for gestational age (HP:0001520)2.37630390
42Broad metatarsal (HP:0001783)2.36524378
43Metabolic alkalosis (HP:0200114)2.34681147
44Neuronal loss in central nervous system (HP:0002529)2.33486025
45Polyuria (HP:0000103)2.31684234
46Epileptic encephalopathy (HP:0200134)2.31354473
47Intention tremor (HP:0002080)2.28138741
48Polyphagia (HP:0002591)2.27828338
49Exercise-induced myalgia (HP:0003738)2.26595176
50Increased neuronal autofluorescent lipopigment (HP:0002074)2.25700235
51Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.24814031
52Craniofacial dystonia (HP:0012179)2.24505995
53Renovascular hypertension (HP:0100817)2.23086697
54Focal dystonia (HP:0004373)2.21068938
55Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.20766607
56Degeneration of the lateral corticospinal tracts (HP:0002314)2.20766607
57Cerebral hypomyelination (HP:0006808)2.19333684
58Abnormal urine output (HP:0012590)2.19163327
59Diminished motivation (HP:0000745)2.18855808
60Abnormality of calcium-phosphate metabolism (HP:0100530)2.18435313
61Megalencephaly (HP:0001355)2.18084959
62Sleep apnea (HP:0010535)2.17168940
63Type 1 muscle fiber predominance (HP:0003803)2.16911054
64Abnormality of glycosphingolipid metabolism (HP:0004343)2.16141552
65Abnormality of glycolipid metabolism (HP:0010969)2.16141552
66Abnormality of liposaccharide metabolism (HP:0010968)2.16141552
67Agitation (HP:0000713)2.15538766
68Split foot (HP:0001839)2.15195215
69Hyperglycinemia (HP:0002154)2.14840258
70Lower limb asymmetry (HP:0100559)2.14817963
71Abnormality of monocarboxylic acid metabolism (HP:0010996)2.14581539
72Cerebral inclusion bodies (HP:0100314)2.14443749
73Round ear (HP:0100830)2.13935350
74Mucopolysacchariduria (HP:0008155)2.12224150
75Urinary glycosaminoglycan excretion (HP:0003541)2.12224150
76Hypercortisolism (HP:0001578)2.11706649
77Hyporeflexia of lower limbs (HP:0002600)2.10553372
78Macroorchidism (HP:0000053)2.10387543
79Pointed chin (HP:0000307)2.10330269
80Insomnia (HP:0100785)2.10162764
81Agammaglobulinemia (HP:0004432)2.07613698
82Papilledema (HP:0001085)2.06389211
83Mitral regurgitation (HP:0001653)2.06277013
84Flat cornea (HP:0007720)2.06244003
85Polydipsia (HP:0001959)2.05120679
86Abnormal drinking behavior (HP:0030082)2.05120679
87Easy fatigability (HP:0003388)2.04776813
88Choreoathetosis (HP:0001266)2.04425321
89Xanthomatosis (HP:0000991)2.04078982
90Supranuclear gaze palsy (HP:0000605)2.03842039
91Hyperphosphaturia (HP:0003109)2.03292204
92Neoplasm of the heart (HP:0100544)2.03260377
93Abnormality of polysaccharide metabolism (HP:0011012)2.03075669
94Abnormality of glycosaminoglycan metabolism (HP:0004371)2.03075669
95Abnormality of mucopolysaccharide metabolism (HP:0011020)2.03075669
96Abnormality of glycine metabolism (HP:0010895)2.02412340
97Abnormality of serine family amino acid metabolism (HP:0010894)2.02412340
98Gowers sign (HP:0003391)2.00954368
99Apathy (HP:0000741)2.00497107
100Protrusio acetabuli (HP:0003179)2.00340335
101Hyperammonemia (HP:0001987)2.00276476
102Bowel diverticulosis (HP:0005222)1.99506794
103Febrile seizures (HP:0002373)1.99414138
104Axonal loss (HP:0003447)1.98210940
105Cellulitis (HP:0100658)1.96852126
106Bulbar palsy (HP:0001283)1.96740887
107Peripheral hypomyelination (HP:0007182)1.96720663
108Abnormality of renin-angiotensin system (HP:0000847)1.96638554
109Generalized tonic-clonic seizures (HP:0002069)1.96045370
110Achilles tendon contracture (HP:0001771)1.95873849
111Myokymia (HP:0002411)1.95261108
112Spastic gait (HP:0002064)1.95147042
113Hypomagnesemia (HP:0002917)1.94133369
114Hypobetalipoproteinemia (HP:0003563)1.93077032
115Abnormal urine phosphate concentration (HP:0012599)1.92629363
116Foot dorsiflexor weakness (HP:0009027)1.91339483
117Turricephaly (HP:0000262)1.90447765
118Renal salt wasting (HP:0000127)1.89893103
119Back pain (HP:0003418)1.89492826
120Absent rod-and cone-mediated responses on ERG (HP:0007688)1.88567662
121Growth hormone excess (HP:0000845)1.88527504
122Type II lissencephaly (HP:0007260)1.86986060
123Nonprogressive disorder (HP:0003680)1.86928123
124Asymmetric septal hypertrophy (HP:0001670)1.86902826
125Anteriorly placed anus (HP:0001545)1.86821070
126Pheochromocytoma (HP:0002666)1.86027591
127Hypokalemia (HP:0002900)1.85716698
128Hypercalcemia (HP:0003072)1.85412630
129Scanning speech (HP:0002168)1.84948856
130CNS hypomyelination (HP:0003429)1.84716485
131Abnormality of the corticospinal tract (HP:0002492)1.84322207
132Alacrima (HP:0000522)1.84137623
133Increased variability in muscle fiber diameter (HP:0003557)1.82955490
134Bundle branch block (HP:0011710)1.82426773
135Overriding aorta (HP:0002623)1.82197344
136Athetosis (HP:0002305)1.82101002
137Generalized aminoaciduria (HP:0002909)1.81854922
138Thoracic kyphosis (HP:0002942)1.81853935
139Irritability (HP:0000737)1.81154965
140Hyperacusis (HP:0010780)1.80687166
141Congenital glaucoma (HP:0001087)1.80520493
142Joint stiffness (HP:0001387)1.80449073
143Abnormality of renal excretion (HP:0011036)1.80212624
144Upper limb amyotrophy (HP:0009129)1.80151795
145Distal upper limb amyotrophy (HP:0007149)1.80151795
146Postural tremor (HP:0002174)1.79820676
147Truncus arteriosus (HP:0001660)1.78338064
148Nuclear cataract (HP:0100018)1.78261450
149Deformed sella turcica (HP:0002681)1.77828095
150Restlessness (HP:0000711)1.77778866
151Anxiety (HP:0000739)1.76891040
152Hypercalciuria (HP:0002150)1.76686095
153Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.76177293
154Myopathic facies (HP:0002058)1.75853502
155Enlarged kidneys (HP:0000105)1.75515157
156Buphthalmos (HP:0000557)1.74507722
157Abnormality of fatty-acid metabolism (HP:0004359)1.73276759
158Thin ribs (HP:0000883)1.72884263
159Gonadal dysgenesis (HP:0000133)1.72838036
160Morphological abnormality of the pyramidal tract (HP:0002062)1.72820081
161Abnormality of skeletal muscle fiber size (HP:0012084)1.72413085
162Hyperparathyroidism (HP:0000843)1.72331082
163Distal arthrogryposis (HP:0005684)1.71592282
164Nemaline bodies (HP:0003798)1.71061094
165Elfin facies (HP:0004428)1.69979988
166Psychosis (HP:0000709)1.69885289
167Abnormality of the periventricular white matter (HP:0002518)1.69558478
168Retinal dysplasia (HP:0007973)1.69301634
169Abnormality of the foot musculature (HP:0001436)1.68901068
170Dysphonia (HP:0001618)1.68232450
171Depression (HP:0000716)1.67747621
172Hypsarrhythmia (HP:0002521)1.67688850
173Dysmetria (HP:0001310)1.67250268
174Testicular neoplasm (HP:0010788)1.66666365
175Progressive neurologic deterioration (HP:0002344)1.66514962
176Abnormality of magnesium homeostasis (HP:0004921)1.66039244
177EEG with generalized epileptiform discharges (HP:0011198)1.65170284
178Status epilepticus (HP:0002133)1.63390610
179Brushfield spots (HP:0001088)1.62886321
180Centrally nucleated skeletal muscle fibers (HP:0003687)1.61357154
181Conjugated hyperbilirubinemia (HP:0002908)1.61106796
182Renal duplication (HP:0000075)1.59147946
183Hyperaldosteronism (HP:0000859)1.56465447

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K102.96128810
2NME22.92269361
3CDK192.91669756
4OXSR12.79582600
5WNK42.79266578
6BCKDK2.78222037
7FLT32.72280000
8ICK2.70042829
9STK392.67369221
10UHMK12.64126003
11MARK12.48302855
12MAPK152.40378520
13MAP3K112.29932215
14INSRR2.19000702
15DAPK22.10273993
16PASK2.07315370
17PRKD31.98936007
18PRPF4B1.85690402
19EEF2K1.84606098
20HIPK21.83620658
21NTRK21.79730292
22TRIB31.72881773
23NTRK11.64352016
24PKN21.58826132
25ARAF1.57280637
26EPHB11.53580399
27TESK11.50856721
28MAPKAPK51.48097317
29SIK11.46337241
30RIPK11.42403252
31MAP3K41.41028052
32PNCK1.38428410
33RPS6KA21.36981624
34MARK21.36172706
35PHKG21.35546484
36PHKG11.35546484
37DYRK1B1.35112847
38ERN11.33790125
39WNK11.33259080
40WNK31.32965905
41SMG11.32426131
42CSNK1G31.29568633
43EPHA41.29264712
44MAP2K41.25507003
45MAPK121.23842140
46PTK61.18007886
47FGFR21.17831630
48TGFBR11.12826677
49DYRK31.12496398
50CSNK1A1L1.11864471
51SCYL21.11173876
52MAP3K91.07187275
53CSF1R1.02837018
54PAK61.01348602
55CAMK1G0.99380486
56CSNK1G10.95360558
57RPS6KL10.92896706
58RPS6KC10.92896706
59CSNK1G20.92282392
60MAP3K70.91966268
61DMPK0.90963296
62MAP2K20.90339320
63CAMK10.88870163
64BTK0.88804035
65RET0.85879127
66LMTK20.85417012
67PIM20.85174767
68TLK10.84911507
69DDR20.84011910
70MAP3K10.82910649
71LATS20.82874626
72DAPK10.82867846
73TTN0.81305669
74MINK10.81296851
75PAK30.80253431
76PRKD20.80029338
77ADRBK20.79841067
78ABL20.79531541
79MAPK40.79393596
80VRK20.79187085
81MUSK0.78681097
82TYRO30.78192481
83TBK10.77914662
84BRAF0.77306085
85TNIK0.74629140
86PRKD10.72176141
87CDK140.71718823
88PTK20.71563316
89CAMKK20.70962362
90RPS6KA60.70347226
91CDK150.69767352
92CAMKK10.68878232
93SGK4940.68108273
94SGK2230.68108273
95CDK11A0.67908210
96PAK40.67796196
97ROCK20.67334792
98PIK3CG0.65333610
99NTRK30.64955771
100PRKCG0.64890522
101RPS6KB20.64632949
102IRAK30.63919287
103CDK50.63654486
104TAOK20.63294095
105CDK80.62631995
106TESK20.62596975
107CDK180.62082965
108ILK0.61820154
109MAPKAPK30.61374445
110FES0.60262672
111ALK0.59087552
112PDPK10.58704070
113STK110.58657606
114PAK20.57950668
115KIT0.57453098
116CAMK40.56962022
117MAP2K70.56818657
118TNK20.56196883
119MAPK70.56075699
120TGFBR20.55088550
121CAMK2B0.54319344
122PKN10.54268353
123OBSCN0.53043004
124MAP2K10.52663500
125LRRK20.52610098
126MAPK100.52549500
127SGK20.50946336
128PDGFRA0.49859540
129CLK10.49402634
130CAMK2G0.49214128
131DAPK30.49118764
132MAP4K10.49013280
133MET0.48957606
134GRK60.47814726
135SIK20.47123056
136PRKCH0.45919089
137MATK0.45090458
138MAPK130.41912733
139CAMK2D0.39483323
140PINK10.37930605
141LIMK10.37836318
142MTOR0.36394551
143NEK60.35114597
144PDK10.34935875
145DYRK1A0.34776463

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.50143635
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.71159317
3Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.58507427
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.23225172
5Butanoate metabolism_Homo sapiens_hsa006502.19571279
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.11122016
7Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.07865463
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.01253663
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.95877325
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.84426174
11Cyanoamino acid metabolism_Homo sapiens_hsa004601.78996866
12Sulfur metabolism_Homo sapiens_hsa009201.73479036
13Glycosaminoglycan degradation_Homo sapiens_hsa005311.72114159
14Other glycan degradation_Homo sapiens_hsa005111.68684382
15Fatty acid elongation_Homo sapiens_hsa000621.63869835
16Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.63109789
17Arginine biosynthesis_Homo sapiens_hsa002201.62582241
18Cardiac muscle contraction_Homo sapiens_hsa042601.61740556
19Tryptophan metabolism_Homo sapiens_hsa003801.61314602
20Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.60624450
21Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.57959768
22Protein export_Homo sapiens_hsa030601.56091997
23Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.56054876
24Propanoate metabolism_Homo sapiens_hsa006401.53903514
25Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.48415484
26Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.47252509
27Folate biosynthesis_Homo sapiens_hsa007901.42172076
28Insulin secretion_Homo sapiens_hsa049111.41699979
29Lysosome_Homo sapiens_hsa041421.41402436
30Oxytocin signaling pathway_Homo sapiens_hsa049211.41000944
31Fatty acid degradation_Homo sapiens_hsa000711.37171430
32Selenocompound metabolism_Homo sapiens_hsa004501.35883738
33Dilated cardiomyopathy_Homo sapiens_hsa054141.35791487
34Bile secretion_Homo sapiens_hsa049761.30336106
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.28156124
36Pyruvate metabolism_Homo sapiens_hsa006201.27683448
37Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.24876554
38Phospholipase D signaling pathway_Homo sapiens_hsa040721.20240860
39Peroxisome_Homo sapiens_hsa041461.18857112
40Histidine metabolism_Homo sapiens_hsa003401.18497935
41Notch signaling pathway_Homo sapiens_hsa043301.18089060
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.17168460
43B cell receptor signaling pathway_Homo sapiens_hsa046621.16890190
44Sulfur relay system_Homo sapiens_hsa041221.15906737
45Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.14827804
46GABAergic synapse_Homo sapiens_hsa047271.12495086
47Fatty acid metabolism_Homo sapiens_hsa012121.10964004
48Neurotrophin signaling pathway_Homo sapiens_hsa047221.10712408
49Pentose phosphate pathway_Homo sapiens_hsa000301.07619945
50VEGF signaling pathway_Homo sapiens_hsa043701.04701729
51Glutamatergic synapse_Homo sapiens_hsa047241.03112021
52Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.99984910
53Arginine and proline metabolism_Homo sapiens_hsa003300.99876690
54Pancreatic secretion_Homo sapiens_hsa049720.99088121
55Biosynthesis of amino acids_Homo sapiens_hsa012300.99003328
56Cocaine addiction_Homo sapiens_hsa050300.98099524
57Renin secretion_Homo sapiens_hsa049240.96867041
58Glioma_Homo sapiens_hsa052140.96123309
59Circadian entrainment_Homo sapiens_hsa047130.96045573
60cAMP signaling pathway_Homo sapiens_hsa040240.94932766
61Collecting duct acid secretion_Homo sapiens_hsa049660.94272527
622-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.93864344
63cGMP-PKG signaling pathway_Homo sapiens_hsa040220.93338544
64Cysteine and methionine metabolism_Homo sapiens_hsa002700.92883411
65GnRH signaling pathway_Homo sapiens_hsa049120.92173363
66Calcium signaling pathway_Homo sapiens_hsa040200.92150729
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.87286747
68Thyroid hormone signaling pathway_Homo sapiens_hsa049190.86703260
69Carbohydrate digestion and absorption_Homo sapiens_hsa049730.85695196
70Endometrial cancer_Homo sapiens_hsa052130.84708899
71Amphetamine addiction_Homo sapiens_hsa050310.82184966
72AMPK signaling pathway_Homo sapiens_hsa041520.81668825
73Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.80574015
74ErbB signaling pathway_Homo sapiens_hsa040120.79696924
75Longevity regulating pathway - mammal_Homo sapiens_hsa042110.78745530
76Gastric acid secretion_Homo sapiens_hsa049710.77692622
77Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.77663755
78Insulin signaling pathway_Homo sapiens_hsa049100.75882432
79Phosphatidylinositol signaling system_Homo sapiens_hsa040700.74693096
80Aldosterone synthesis and secretion_Homo sapiens_hsa049250.74531450
81mTOR signaling pathway_Homo sapiens_hsa041500.73611889
82Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.72943703
83Inositol phosphate metabolism_Homo sapiens_hsa005620.72676653
84Hedgehog signaling pathway_Homo sapiens_hsa043400.72212792
85Long-term potentiation_Homo sapiens_hsa047200.71069816
86Dopaminergic synapse_Homo sapiens_hsa047280.70205756
87Pentose and glucuronate interconversions_Homo sapiens_hsa000400.69587360
88Synaptic vesicle cycle_Homo sapiens_hsa047210.69556213
89Central carbon metabolism in cancer_Homo sapiens_hsa052300.69056508
90Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.68832588
91Lysine degradation_Homo sapiens_hsa003100.68626820
92MAPK signaling pathway_Homo sapiens_hsa040100.68555812
93Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.68343462
94Drug metabolism - other enzymes_Homo sapiens_hsa009830.67991404
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65804858
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.65401838
97Morphine addiction_Homo sapiens_hsa050320.65390207
98Phenylalanine metabolism_Homo sapiens_hsa003600.64149354
99Glucagon signaling pathway_Homo sapiens_hsa049220.64035417
100beta-Alanine metabolism_Homo sapiens_hsa004100.63340153
101Chemical carcinogenesis_Homo sapiens_hsa052040.63184815
102Vitamin B6 metabolism_Homo sapiens_hsa007500.62210987
103Thyroid hormone synthesis_Homo sapiens_hsa049180.62000153
104Carbon metabolism_Homo sapiens_hsa012000.61629127
105Acute myeloid leukemia_Homo sapiens_hsa052210.60936271
106Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.59497696
107Salivary secretion_Homo sapiens_hsa049700.58811731
108Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.58736046
109Endocytosis_Homo sapiens_hsa041440.58203277
110Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.57990398
111Serotonergic synapse_Homo sapiens_hsa047260.57671253
112Vibrio cholerae infection_Homo sapiens_hsa051100.57657772
113Steroid biosynthesis_Homo sapiens_hsa001000.56259767
114Long-term depression_Homo sapiens_hsa047300.56210844
115Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.55884974
116Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.55719179
117Prion diseases_Homo sapiens_hsa050200.55691942
118Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.55592256
119N-Glycan biosynthesis_Homo sapiens_hsa005100.54317777
120Taste transduction_Homo sapiens_hsa047420.54161640
121Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.54093567
122Fat digestion and absorption_Homo sapiens_hsa049750.53319866
123Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53093494
124Non-small cell lung cancer_Homo sapiens_hsa052230.52324950
125Steroid hormone biosynthesis_Homo sapiens_hsa001400.52119129
126Choline metabolism in cancer_Homo sapiens_hsa052310.51486177
127Cholinergic synapse_Homo sapiens_hsa047250.51373791
128Rap1 signaling pathway_Homo sapiens_hsa040150.50483908
129Caffeine metabolism_Homo sapiens_hsa002320.49412195
130PPAR signaling pathway_Homo sapiens_hsa033200.48276458
131Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.47152145
132Vascular smooth muscle contraction_Homo sapiens_hsa042700.47097182
133Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46801436
134Asthma_Homo sapiens_hsa053100.46563491
135Axon guidance_Homo sapiens_hsa043600.46375858
136Estrogen signaling pathway_Homo sapiens_hsa049150.44702465
137Ras signaling pathway_Homo sapiens_hsa040140.42685174
138Protein digestion and absorption_Homo sapiens_hsa049740.42608696
139Tyrosine metabolism_Homo sapiens_hsa003500.42165723
140Alcoholism_Homo sapiens_hsa050340.41760480
141Type II diabetes mellitus_Homo sapiens_hsa049300.41619627
142Wnt signaling pathway_Homo sapiens_hsa043100.41117228
143Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.40635683
144ABC transporters_Homo sapiens_hsa020100.39245448
145Complement and coagulation cascades_Homo sapiens_hsa046100.39232705
146Fructose and mannose metabolism_Homo sapiens_hsa000510.38769707
147Melanogenesis_Homo sapiens_hsa049160.38528180
148Ribosome_Homo sapiens_hsa030100.38459763
149Nicotine addiction_Homo sapiens_hsa050330.38393284
150Gap junction_Homo sapiens_hsa045400.37951920
151Rheumatoid arthritis_Homo sapiens_hsa053230.37184110
152Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.37177845
153Bladder cancer_Homo sapiens_hsa052190.37091821

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