CYB561D2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)5.86085706
2central nervous system myelination (GO:0022010)5.86085706
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.48535867
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.28305954
5chaperone-mediated protein transport (GO:0072321)5.19427357
6energy coupled proton transport, down electrochemical gradient (GO:0015985)5.13554205
7ATP synthesis coupled proton transport (GO:0015986)5.13554205
8fatty acid elongation (GO:0030497)4.97706229
9proteasome assembly (GO:0043248)4.67523336
10respiratory electron transport chain (GO:0022904)4.65513462
11electron transport chain (GO:0022900)4.57248799
12protein neddylation (GO:0045116)4.37054311
13L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.33959143
14signal peptide processing (GO:0006465)4.04535369
15antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.94891542
16protein complex biogenesis (GO:0070271)3.91099636
17mitochondrial respiratory chain complex I assembly (GO:0032981)3.89496834
18NADH dehydrogenase complex assembly (GO:0010257)3.89496834
19mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.89496834
20positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.88215408
21termination of RNA polymerase III transcription (GO:0006386)3.86382682
22transcription elongation from RNA polymerase III promoter (GO:0006385)3.86382682
23long-chain fatty acid biosynthetic process (GO:0042759)3.83624091
24regulation of cellular amino acid metabolic process (GO:0006521)3.79248993
25negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.74748007
26antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.73842817
27positive regulation of gamma-delta T cell activation (GO:0046645)3.71611073
28cholesterol biosynthetic process (GO:0006695)3.65974173
29negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.60519803
30negative regulation of cell killing (GO:0031342)3.60519803
31negative regulation of ligase activity (GO:0051352)3.58507273
32negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.58507273
33cotranslational protein targeting to membrane (GO:0006613)3.56387626
34protein targeting to mitochondrion (GO:0006626)3.56243882
35antigen processing and presentation of endogenous antigen (GO:0019883)3.55219124
36mannosylation (GO:0097502)3.53619917
37immunoglobulin mediated immune response (GO:0016064)3.50218840
38ribosomal small subunit biogenesis (GO:0042274)3.49346318
39antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.48336929
40DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.47422742
41amino acid salvage (GO:0043102)3.47151691
42L-methionine salvage (GO:0071267)3.47151691
43L-methionine biosynthetic process (GO:0071265)3.47151691
44protein targeting to ER (GO:0045047)3.44740032
45protein localization to endoplasmic reticulum (GO:0070972)3.44441689
46mitochondrial respiratory chain complex assembly (GO:0033108)3.43183271
47establishment of protein localization to mitochondrial membrane (GO:0090151)3.42600676
48SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.42546253
49signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.40765988
50intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.40765988
51establishment of protein localization to mitochondrion (GO:0072655)3.40425046
52signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.36024839
53signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.36024839
54signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.36024839
55cytidine metabolic process (GO:0046087)3.34409018
56cytidine catabolic process (GO:0006216)3.34409018
57cytidine deamination (GO:0009972)3.34409018
58GPI anchor biosynthetic process (GO:0006506)3.30642519
59regulation of B cell receptor signaling pathway (GO:0050855)3.30506959
60establishment of protein localization to endoplasmic reticulum (GO:0072599)3.29459715
61positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.29063483
62iron-sulfur cluster assembly (GO:0016226)3.28945733
63metallo-sulfur cluster assembly (GO:0031163)3.28945733
64sterol biosynthetic process (GO:0016126)3.28256649
65viral transcription (GO:0019083)3.27864203
66isoprenoid biosynthetic process (GO:0008299)3.26545224
67GTP biosynthetic process (GO:0006183)3.26337826
68cellular response to interleukin-15 (GO:0071350)3.24304314
697-methylguanosine mRNA capping (GO:0006370)3.23808413
70antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.22384368
71establishment of viral latency (GO:0019043)3.21993005
72signal transduction involved in DNA damage checkpoint (GO:0072422)3.21232080
73signal transduction involved in DNA integrity checkpoint (GO:0072401)3.21232080
74Arp2/3 complex-mediated actin nucleation (GO:0034314)3.20122941
757-methylguanosine RNA capping (GO:0009452)3.18505136
76RNA capping (GO:0036260)3.18505136
77response to interferon-beta (GO:0035456)3.17561443
78signal transduction involved in cell cycle checkpoint (GO:0072395)3.14611360
79cullin deneddylation (GO:0010388)3.13922335
80respiratory chain complex IV assembly (GO:0008535)3.13345019
81DNA deamination (GO:0045006)3.12924753
82regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.11354768
83regulation of cellular amine metabolic process (GO:0033238)3.09635614
84protein localization to mitochondrion (GO:0070585)3.09287982
85translational termination (GO:0006415)3.07937415
86leukocyte aggregation (GO:0070486)3.05323719
87protein deneddylation (GO:0000338)3.04552143
88ubiquinone biosynthetic process (GO:0006744)3.02034850
89quinone biosynthetic process (GO:1901663)3.02034850
90neutrophil activation involved in immune response (GO:0002283)3.01704603
91deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.00442583
92anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.97910685
93GPI anchor metabolic process (GO:0006505)2.96912136
94amyloid precursor protein metabolic process (GO:0042982)2.96904894
95NIK/NF-kappaB signaling (GO:0038061)2.96789863
96positive thymic T cell selection (GO:0045059)2.94767385
97ribosomal small subunit assembly (GO:0000028)2.93304334
98CTP metabolic process (GO:0046036)2.92782228
99CTP biosynthetic process (GO:0006241)2.92782228
100regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.92228287
101ubiquinone metabolic process (GO:0006743)2.91924566
102establishment of integrated proviral latency (GO:0075713)2.91818433
103antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.91238447
104B cell mediated immunity (GO:0019724)2.90311342
105substantia nigra development (GO:0021762)2.89886085
106regulation of mitochondrial translation (GO:0070129)2.88664389
107regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.88419001
108ensheathment of neurons (GO:0007272)2.87698470
109axon ensheathment (GO:0008366)2.87698470
110regulation of regulatory T cell differentiation (GO:0045589)2.87581208
111myelination (GO:0042552)2.87529743
112pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.87290408
113hydrogen ion transmembrane transport (GO:1902600)2.86735850
114protein maturation by protein folding (GO:0022417)2.86632076
115translation (GO:0006412)2.86417567
116pyrimidine ribonucleoside catabolic process (GO:0046133)2.84011264
117T cell migration (GO:0072678)2.83883749
118preassembly of GPI anchor in ER membrane (GO:0016254)2.81626655
119antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.81278376
120negative T cell selection (GO:0043383)2.80797899
121regulation of T cell mediated cytotoxicity (GO:0001914)2.75830193
122peptidyl-histidine modification (GO:0018202)2.75180340
123positive regulation of T cell mediated cytotoxicity (GO:0001916)2.74501132
124mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.73811195
125positive regulation of interleukin-8 secretion (GO:2000484)2.72795583
126positive regulation of ligase activity (GO:0051351)2.72474861
127regulation of T cell receptor signaling pathway (GO:0050856)2.72099526
128guanosine-containing compound biosynthetic process (GO:1901070)2.72009047
129cytochrome complex assembly (GO:0017004)2.71458228
130type I interferon signaling pathway (GO:0060337)2.69824514
131cellular response to type I interferon (GO:0071357)2.69824514
132nucleotide transmembrane transport (GO:1901679)2.69722618
133GDP-mannose metabolic process (GO:0019673)2.69083948
134proton transport (GO:0015992)2.68876841
135response to interleukin-15 (GO:0070672)2.68799768
136positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.68763421
137actin nucleation (GO:0045010)2.68378675
138oxidative phosphorylation (GO:0006119)2.68315473
139negative regulation of interleukin-12 production (GO:0032695)2.68228545
140regulation of chronic inflammatory response (GO:0002676)2.66365458
141deoxyribonucleotide catabolic process (GO:0009264)2.65919449
142positive regulation of monocyte chemotaxis (GO:0090026)2.65461180
143response to type I interferon (GO:0034340)2.64176589
144purine nucleotide salvage (GO:0032261)2.62572681
145autophagic vacuole fusion (GO:0000046)2.62230965
146purine deoxyribonucleotide catabolic process (GO:0009155)2.61819962
147response to peptidoglycan (GO:0032494)2.59068013
148regulation of activation of Janus kinase activity (GO:0010533)2.57935086
149deoxyribose phosphate catabolic process (GO:0046386)2.57894061
150regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.57503423
151positive T cell selection (GO:0043368)2.56489119
152regulation of gamma-delta T cell activation (GO:0046643)2.55404786
153detection of bacterium (GO:0016045)2.54933330
154respiratory burst (GO:0045730)2.53748945
155regulation of gamma-delta T cell differentiation (GO:0045586)2.53277016
156base-excision repair, AP site formation (GO:0006285)2.53114430
157regulation of T cell tolerance induction (GO:0002664)2.52305351
158negative regulation of innate immune response (GO:0045824)2.52211905
159positive regulation of B cell differentiation (GO:0045579)2.52070675
160regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.51380563
161regulation of natural killer cell mediated immunity (GO:0002715)2.51380563
162negative regulation of nitric oxide biosynthetic process (GO:0045019)2.50174041
163antigen processing and presentation via MHC class Ib (GO:0002475)2.49285286
164regulation of leukocyte mediated cytotoxicity (GO:0001910)2.48709972
165positive regulation of natural killer cell differentiation (GO:0032825)2.48233908
166regulation of superoxide anion generation (GO:0032928)2.47664055
167detection of other organism (GO:0098543)2.46852154
168positive regulation of isotype switching (GO:0045830)2.46390932
169granulocyte activation (GO:0036230)2.43850506
170negative regulation of T cell apoptotic process (GO:0070233)2.43731409
171regulation of alpha-beta T cell proliferation (GO:0046640)2.43697916
172cellular response to zinc ion (GO:0071294)2.43239661
173positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.39767564
174neutrophil activation (GO:0042119)2.39528668
175pyrimidine nucleotide catabolic process (GO:0006244)2.36528304
176cellular response to interferon-beta (GO:0035458)2.36414778

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.94765475
2* NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.97429789
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.76454688
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.73612878
5EST1_17652178_ChIP-ChIP_JURKAT_Human4.16838732
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.11269427
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.08979188
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.53425486
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.44167648
10CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.38443070
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.20701365
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.19722778
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.96497931
14PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.84390662
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.72488341
16EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.70467838
17SRF_21415370_ChIP-Seq_HL-1_Mouse2.61018244
18VDR_23849224_ChIP-Seq_CD4+_Human2.54501979
19* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.37341224
20MYC_18555785_ChIP-Seq_MESCs_Mouse2.32908180
21* THAP11_20581084_ChIP-Seq_MESCs_Mouse2.28939311
22IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.05627179
23FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.03615521
24STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.01992436
25NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.99631150
26FOXP3_21729870_ChIP-Seq_TREG_Human1.99009657
27SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.97199103
28DCP1A_22483619_ChIP-Seq_HELA_Human1.96756958
29SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.94296220
30FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.94274247
31E2F1_18555785_ChIP-Seq_MESCs_Mouse1.90584791
32* VDR_21846776_ChIP-Seq_THP-1_Human1.87351151
33IRF8_21731497_ChIP-ChIP_J774_Mouse1.86965368
34ELK1_19687146_ChIP-ChIP_HELA_Human1.85479805
35IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.82014686
36* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.80591655
37YY1_21170310_ChIP-Seq_MESCs_Mouse1.75905360
38HOXB4_20404135_ChIP-ChIP_EML_Mouse1.75291533
39MYB_26560356_Chip-Seq_TH2_Human1.75281170
40MYC_19030024_ChIP-ChIP_MESCs_Mouse1.74616097
41GABP_19822575_ChIP-Seq_HepG2_Human1.74391431
42XRN2_22483619_ChIP-Seq_HELA_Human1.73004482
43ERG_20887958_ChIP-Seq_HPC-7_Mouse1.71118932
44UTX_26944678_Chip-Seq_JUKART_Human1.67740033
45ELK1_22589737_ChIP-Seq_MCF10A_Human1.65874206
46MAF_26560356_Chip-Seq_TH1_Human1.64524224
47MAF_26560356_Chip-Seq_TH2_Human1.62215937
48BCL6_27268052_Chip-Seq_Bcells_Human1.60855826
49VDR_24763502_ChIP-Seq_THP-1_Human1.43494418
50PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.43165599
51CIITA_25753668_ChIP-Seq_RAJI_Human1.42160380
52IRF8_27001747_Chip-Seq_BMDM_Mouse1.41892512
53ELF1_20517297_ChIP-Seq_JURKAT_Human1.40952330
54TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40462466
55BCOR_27268052_Chip-Seq_Bcells_Human1.40223895
56TTF2_22483619_ChIP-Seq_HELA_Human1.39618947
57TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.38943258
58SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.38697455
59MYB_26560356_Chip-Seq_TH1_Human1.36576234
60* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.35927605
61NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.35463675
62RUNX1_22412390_ChIP-Seq_EML_Mouse1.35326074
63E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.34606942
64TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.33279347
65IRF1_19129219_ChIP-ChIP_H3396_Human1.30814383
66MYC_19079543_ChIP-ChIP_MESCs_Mouse1.29451183
67NOTCH1_21737748_ChIP-Seq_TLL_Human1.27866535
68CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24157099
69STAT4_19710469_ChIP-ChIP_TH1__Mouse1.24022011
70LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.23512599
71POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.22868263
72SPI1_23547873_ChIP-Seq_NB4_Human1.22445321
73BRD4_27068464_Chip-Seq_AML-cells_Mouse1.22435182
74PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21765628
75* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.21270180
76LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.21133210
77CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20877294
78SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20030279
79TFEB_21752829_ChIP-Seq_HELA_Human1.19690074
80SRY_22984422_ChIP-ChIP_TESTIS_Rat1.19485782
81IRF8_22096565_ChIP-ChIP_GC-B_Human1.18870142
82SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.16859314
83PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16566613
84MYC_18940864_ChIP-ChIP_HL60_Human1.16522553
85FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.15260257
86NELFA_20434984_ChIP-Seq_ESCs_Mouse1.12348327
87CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.12170171
88ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.11790380
89GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.10451266
90GATA3_26560356_Chip-Seq_TH2_Human1.08715680
91CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.08588638
92MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.07958721
93TAF15_26573619_Chip-Seq_HEK293_Human1.07936334
94TET1_21451524_ChIP-Seq_MESCs_Mouse1.07273611
95P68_20966046_ChIP-Seq_HELA_Human1.06960970
96LXR_22292898_ChIP-Seq_THP-1_Human1.06717950
97DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.06529383
98GATA3_27048872_Chip-Seq_THYMUS_Human1.06439776
99STAT1_20625510_ChIP-Seq_HELA_Human1.04022012
100GATA2_22383799_ChIP-Seq_G1ME_Mouse1.03735619
101MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.97886245
102* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97728304
103RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.97484806
104CTCF_18555785_ChIP-Seq_MESCs_Mouse0.96872216
105* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.95955142
106PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.92512911
107BP1_19119308_ChIP-ChIP_Hs578T_Human0.91081090
108TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90251397
109* CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.88174679
110SOX17_20123909_ChIP-Seq_XEN_Mouse0.88111371
111GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.86239739
112EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.85755781
113ZFP57_27257070_Chip-Seq_ESCs_Mouse0.83313320
114PU.1_20513432_ChIP-Seq_Bcells_Mouse0.80948316
115CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.80279339
116MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.79141168
117CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.78661927
118* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.78583124
119SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.78559641
120FUS_26573619_Chip-Seq_HEK293_Human0.78353035
121PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.78329028
122TBX5_21415370_ChIP-Seq_HL-1_Mouse0.77352557
123BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.77072272
124ETV2_25802403_ChIP-Seq_MESCs_Mouse0.76745753
125YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.76399748
126GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.76168921
127CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.75497431
128NANOG_20526341_ChIP-Seq_ESCs_Human0.74572379
129ELF5_23300383_ChIP-Seq_T47D_Human0.73868867
130ZFX_18555785_ChIP-Seq_MESCs_Mouse0.73433936
131TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.71831071
132EOMES_21245162_ChIP-Seq_HESCs_Human0.70351153
133MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.69975732
134HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.69041302
135YY1_22570637_ChIP-Seq_MALME-3M_Human0.68955430
136E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.68837884
137CTCF_26484167_Chip-Seq_Bcells_Mouse0.68353583
138FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.67931185
139HTT_18923047_ChIP-ChIP_STHdh_Human0.67746494
140RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.67324033
141SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.66199828
142MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.66038399

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.69572612
2MP0001529_abnormal_vocalization3.67038805
3MP0001905_abnormal_dopamine_level3.37030776
4MP0000920_abnormal_myelination3.23728383
5MP0005671_abnormal_response_to2.46492890
6MP0003191_abnormal_cellular_cholesterol2.42745152
7MP0009840_abnormal_foam_cell2.36995231
8MP0003806_abnormal_nucleotide_metabolis2.23977314
9MP0003136_yellow_coat_color2.22087386
10MP0001986_abnormal_taste_sensitivity2.19828811
11MP0000685_abnormal_immune_system2.17573092
12MP0006082_CNS_inflammation2.13251877
13MP0004142_abnormal_muscle_tone2.12471067
14MP0004147_increased_porphyrin_level2.09572797
15MP0003724_increased_susceptibility_to2.04839865
16MP0001348_abnormal_lacrimal_gland1.90890685
17MP0001873_stomach_inflammation1.89933828
18MP0009785_altered_susceptibility_to1.87829585
19MP0002405_respiratory_system_inflammati1.85820998
20MP0001845_abnormal_inflammatory_respons1.81724688
21MP0000372_irregular_coat_pigmentation1.80862284
22MP0005379_endocrine/exocrine_gland_phen1.78200841
23MP0010155_abnormal_intestine_physiology1.78160505
24MP0002736_abnormal_nociception_after1.77422979
25MP0003329_amyloid_beta_deposits1.76401460
26MP0006036_abnormal_mitochondrial_physio1.73650952
27MP0001853_heart_inflammation1.73393493
28MP0005171_absent_coat_pigmentation1.69643929
29MP0005075_abnormal_melanosome_morpholog1.69386561
30MP0001533_abnormal_skeleton_physiology1.68901188
31MP0001835_abnormal_antigen_presentation1.68882616
32MP0001968_abnormal_touch/_nociception1.65618883
33MP0003186_abnormal_redox_activity1.65043684
34MP0005464_abnormal_platelet_physiology1.63118833
35MP0008260_abnormal_autophagy1.62322012
36MP0006276_abnormal_autonomic_nervous1.61375641
37MP0002272_abnormal_nervous_system1.57575351
38MP0005409_darkened_coat_color1.53508369
39MP0002148_abnormal_hypersensitivity_rea1.49854551
40MP0005000_abnormal_immune_tolerance1.49440755
41MP0001790_abnormal_immune_system1.48874101
42MP0005387_immune_system_phenotype1.48874101
43MP0005025_abnormal_response_to1.47041698
44MP0009764_decreased_sensitivity_to1.46957287
45MP0004381_abnormal_hair_follicle1.46323728
46MP0003718_maternal_effect1.44724862
47MP0009379_abnormal_foot_pigmentation1.42116600
48MP0002734_abnormal_mechanical_nocicepti1.41001073
49MP0010386_abnormal_urinary_bladder1.40961029
50MP0000858_altered_metastatic_potential1.38286549
51MP0002163_abnormal_gland_morphology1.38265249
52MP0001970_abnormal_pain_threshold1.37509028
53MP0002735_abnormal_chemical_nociception1.36527121
54MP0003656_abnormal_erythrocyte_physiolo1.36451429
55MP0009333_abnormal_splenocyte_physiolog1.36314942
56MP0002166_altered_tumor_susceptibility1.35716691
57MP0005058_abnormal_lysosome_morphology1.34418298
58MP0004742_abnormal_vestibular_system1.34327427
59MP0004947_skin_inflammation1.33615757
60MP0002723_abnormal_immune_serum1.33478996
61MP0004270_analgesia1.33330119
62MP0005410_abnormal_fertilization1.32326097
63MP0003303_peritoneal_inflammation1.32024106
64MP0002876_abnormal_thyroid_physiology1.31094420
65MP0002064_seizures1.30332706
66MP0000343_altered_response_to1.28951942
67MP0002420_abnormal_adaptive_immunity1.26713971
68MP0009278_abnormal_bone_marrow1.26656323
69MP0005451_abnormal_body_composition1.25464808
70MP0005423_abnormal_somatic_nervous1.25202688
71MP0008875_abnormal_xenobiotic_pharmacok1.24588249
72MP0006035_abnormal_mitochondrial_morpho1.23614898
73MP0001819_abnormal_immune_cell1.23089887
74MP0003075_altered_response_to1.20516650
75MP0002419_abnormal_innate_immunity1.18228827
76MP0002229_neurodegeneration1.17722236
77MP0002277_abnormal_respiratory_mucosa1.16366199
78MP0000703_abnormal_thymus_morphology1.16070856
79MP0001485_abnormal_pinna_reflex1.15840693
80MP0005310_abnormal_salivary_gland1.15550518
81MP0001800_abnormal_humoral_immune1.15093082
82MP0000604_amyloidosis1.14362743
83MP0003763_abnormal_thymus_physiology1.13596536
84MP0002733_abnormal_thermal_nociception1.13197654
85MP0003690_abnormal_glial_cell1.12532741
86MP0002132_abnormal_respiratory_system1.11646379
87MP0003634_abnormal_glial_cell1.10580557
88MP0002452_abnormal_antigen_presenting1.07568197
89MP0003448_altered_tumor_morphology1.07276043
90MP0005174_abnormal_tail_pigmentation1.06960254
91MP0009046_muscle_twitch1.05458339
92MP0002006_tumorigenesis1.05082325
93MP0003866_abnormal_defecation1.04920285
94MP0009745_abnormal_behavioral_response1.03904057
95MP0003786_premature_aging1.01078325
96MP0000716_abnormal_immune_system1.00664151
97MP0001542_abnormal_bone_strength0.99279683
98MP0009763_increased_sensitivity_to0.98089893
99MP0005408_hypopigmentation0.97775013
100MP0002396_abnormal_hematopoietic_system0.96706238
101MP0000490_abnormal_crypts_of0.94233531
102MP0002933_joint_inflammation0.94156769
103MP0005319_abnormal_enzyme/_coenzyme0.93578305
104MP0001727_abnormal_embryo_implantation0.93224032
105MP0005166_decreased_susceptibility_to0.92494296
106MP0003950_abnormal_plasma_membrane0.92242185
107MP0008058_abnormal_DNA_repair0.92234865
108MP0002398_abnormal_bone_marrow0.91560429
109MP0000015_abnormal_ear_pigmentation0.90671348
110MP0000689_abnormal_spleen_morphology0.89923352
111MP0001963_abnormal_hearing_physiology0.89009463
112MP0005365_abnormal_bile_salt0.87102165
113MP0001440_abnormal_grooming_behavior0.86974398
114MP0001764_abnormal_homeostasis0.86479853
115MP0000465_gastrointestinal_hemorrhage0.85910972
116MP0002429_abnormal_blood_cell0.85154584
117MP0002653_abnormal_ependyma_morphology0.84794439
118MP0000681_abnormal_thyroid_gland0.84296076
119MP0001661_extended_life_span0.83840246
120MP0005397_hematopoietic_system_phenotyp0.83546991
121MP0001545_abnormal_hematopoietic_system0.83546991
122MP0002138_abnormal_hepatobiliary_system0.83174639
123MP0009643_abnormal_urine_homeostasis0.83005459
124MP0002019_abnormal_tumor_incidence0.82569031
125MP0005360_urolithiasis0.82152830
126MP0008932_abnormal_embryonic_tissue0.82082879
127MP0002998_abnormal_bone_remodeling0.81478196
128MP0002572_abnormal_emotion/affect_behav0.80233815
129MP0002722_abnormal_immune_system0.79972144
130MP0008469_abnormal_protein_level0.77945574
131MP0002095_abnormal_skin_pigmentation0.77704721
132MP0004924_abnormal_behavior0.77703572
133MP0005386_behavior/neurological_phenoty0.77703572
134MP0000358_abnormal_cell_content/0.77585237
135MP0002067_abnormal_sensory_capabilities0.77449118
136MP0003172_abnormal_lysosome_physiology0.76860938
137MP0003436_decreased_susceptibility_to0.76566551
138MP0001486_abnormal_startle_reflex0.75779034
139MP0005584_abnormal_enzyme/coenzyme_acti0.74679580
140MP0001663_abnormal_digestive_system0.72550993
141MP0002877_abnormal_melanocyte_morpholog0.70918542
142MP0002139_abnormal_hepatobiliary_system0.69757870
143MP0000609_abnormal_liver_physiology0.68895568
144MP0005390_skeleton_phenotype0.65361414
145MP0005332_abnormal_amino_acid0.64144261
146MP0003300_gastrointestinal_ulcer0.62288777
147MP0002254_reproductive_system_inflammat0.61248739

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.72490557
2Abnormal mitochondria in muscle tissue (HP:0008316)5.21540211
3Mitochondrial inheritance (HP:0001427)5.13842927
4Acute encephalopathy (HP:0006846)4.69361845
5Hepatocellular necrosis (HP:0001404)4.67335046
6Progressive macrocephaly (HP:0004481)4.60311959
7Increased CSF lactate (HP:0002490)4.34594133
8Abnormality of glycolysis (HP:0004366)4.31274874
9Increased serum pyruvate (HP:0003542)4.31274874
103-Methylglutaconic aciduria (HP:0003535)4.27422747
11Cerebral hypomyelination (HP:0006808)4.08200720
12Renal Fanconi syndrome (HP:0001994)4.06469229
13Hepatic necrosis (HP:0002605)4.03955606
14Increased hepatocellular lipid droplets (HP:0006565)4.03930575
15Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.91602291
16Stomatitis (HP:0010280)3.75507577
17Abnormality of liposaccharide metabolism (HP:0010968)3.67845561
18Abnormality of glycosphingolipid metabolism (HP:0004343)3.67845561
19Abnormality of glycolipid metabolism (HP:0010969)3.67845561
20Leukodystrophy (HP:0002415)3.53954639
21Lipid accumulation in hepatocytes (HP:0006561)3.51508989
22T lymphocytopenia (HP:0005403)3.44545039
23Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.44223222
24Parakeratosis (HP:0001036)3.41786047
25Decreased activity of mitochondrial respiratory chain (HP:0008972)3.37470620
26Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.37470620
27Abnormality of T cell number (HP:0011839)3.24991281
28Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.24497512
29Increased serum lactate (HP:0002151)3.18456513
30Eczematoid dermatitis (HP:0000976)3.13153584
31Increased intramyocellular lipid droplets (HP:0012240)3.12625855
32Cerebral edema (HP:0002181)3.09223558
33Obstructive lung disease (HP:0006536)3.03557781
34Chronic obstructive pulmonary disease (HP:0006510)3.03557781
35Myositis (HP:0100614)3.01847722
36Respiratory failure (HP:0002878)3.01846553
37Increased IgM level (HP:0003496)2.99952347
38Recurrent fungal infections (HP:0002841)2.98000657
39Lactic acidosis (HP:0003128)2.94729667
40Mediastinal lymphadenopathy (HP:0100721)2.83954838
41Abnormality of T cells (HP:0002843)2.83846014
42Neuroendocrine neoplasm (HP:0100634)2.82151168
43Recurrent bacterial skin infections (HP:0005406)2.77332774
44Congenital ichthyosiform erythroderma (HP:0007431)2.76497471
45Recurrent cutaneous fungal infections (HP:0011370)2.76314538
46Chronic mucocutaneous candidiasis (HP:0002728)2.76314538
47Exertional dyspnea (HP:0002875)2.75404004
48Optic disc pallor (HP:0000543)2.75177482
49Exercise intolerance (HP:0003546)2.75110208
50Neurofibrillary tangles (HP:0002185)2.73999199
51CNS hypomyelination (HP:0003429)2.70554957
52Abnormality of cells of the erythroid lineage (HP:0012130)2.65535376
53Retinal dysplasia (HP:0007973)2.58428271
54Combined immunodeficiency (HP:0005387)2.57646316
55Orchitis (HP:0100796)2.56130720
56Abnormality of renal resorption (HP:0011038)2.55948182
57Abnormal number of erythroid precursors (HP:0012131)2.54977172
58Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.54392432
59Degeneration of the lateral corticospinal tracts (HP:0002314)2.54392432
60CNS demyelination (HP:0007305)2.53155691
61Increased muscle lipid content (HP:0009058)2.52435861
62Autoamputation (HP:0001218)2.51673455
63Spastic paraparesis (HP:0002313)2.47704632
64Recurrent viral infections (HP:0004429)2.47041153
65Meningitis (HP:0001287)2.43754174
66Pheochromocytoma (HP:0002666)2.40554394
67Abnormal delayed hypersensitivity skin test (HP:0002963)2.38340154
68Autoimmune thrombocytopenia (HP:0001973)2.36634043
69Recurrent skin infections (HP:0001581)2.36615221
70Gastrointestinal infarctions (HP:0005244)2.36108846
71Increased cerebral lipofuscin (HP:0011813)2.35986779
72Autoimmune hemolytic anemia (HP:0001890)2.35827626
73Hepatosplenomegaly (HP:0001433)2.35424246
74Chronic diarrhea (HP:0002028)2.32279537
75Dysostosis multiplex (HP:0000943)2.30470527
76Optic neuritis (HP:0100653)2.29860793
77Retrobulbar optic neuritis (HP:0100654)2.29860793
78Respiratory difficulties (HP:0002880)2.29689877
79Microvesicular hepatic steatosis (HP:0001414)2.29322729
80Abnormality of T cell physiology (HP:0011840)2.28255047
81Panhypogammaglobulinemia (HP:0003139)2.27316543
82Pulmonary infiltrates (HP:0002113)2.27125720
83Anorexia (HP:0002039)2.25232358
84Delusions (HP:0000746)2.24846185
85Elevated erythrocyte sedimentation rate (HP:0003565)2.24111899
86Petechiae (HP:0000967)2.23757103
87Encephalitis (HP:0002383)2.22746806
88Purpura (HP:0000979)2.21610188
89Abnormality of eosinophils (HP:0001879)2.21279657
90Increased serum ferritin (HP:0003281)2.21272857
91Increased neuronal autofluorescent lipopigment (HP:0002074)2.19373159
92Prolonged neonatal jaundice (HP:0006579)2.19052955
93Type I transferrin isoform profile (HP:0003642)2.17026406
94Vacuolated lymphocytes (HP:0001922)2.16531348
95Emotional lability (HP:0000712)2.15482791
96Pustule (HP:0200039)2.13962783
97Testicular atrophy (HP:0000029)2.13033369
98Systemic lupus erythematosus (HP:0002725)2.10636599
99Abnormality of the prostate (HP:0008775)2.09656546
100Leukocytosis (HP:0001974)2.08880912
101Ragged-red muscle fibers (HP:0003200)2.08421143
102Generalized aminoaciduria (HP:0002909)2.07893107
103Hypothermia (HP:0002045)2.07637951
104Acute hepatic failure (HP:0006554)2.07401167
105Recurrent gram-negative bacterial infections (HP:0005420)2.06892667
106Hypertensive crisis (HP:0100735)2.06515569
107Hypergammaglobulinemia (HP:0010702)2.04618750
108Macrocytic anemia (HP:0001972)2.04210088
109Loss of speech (HP:0002371)2.03729507
110Agammaglobulinemia (HP:0004432)2.02978916
111Birth length less than 3rd percentile (HP:0003561)2.02481954
112Vasculitis (HP:0002633)2.02175423
113Reduced antithrombin III activity (HP:0001976)2.01644854
114Granulocytopenia (HP:0001913)2.00949748
115Aplasia/Hypoplasia of the sacrum (HP:0008517)2.00052183
116Peripheral hypomyelination (HP:0007182)1.99755310
117Abnormality of placental membranes (HP:0011409)1.99486992
118Amniotic constriction ring (HP:0009775)1.99486992
119Urticaria (HP:0001025)1.99330476
120Decreased electroretinogram (ERG) amplitude (HP:0000654)1.98196365
121Postnatal microcephaly (HP:0005484)1.97712465
122Abnormal pupillary function (HP:0007686)1.97453946
123Hemoptysis (HP:0002105)1.95955672
124Eosinophilia (HP:0001880)1.95033594
125X-linked dominant inheritance (HP:0001423)1.94734496
126Sensory axonal neuropathy (HP:0003390)1.93569236
127Abnormal protein glycosylation (HP:0012346)1.93380299
128Abnormal glycosylation (HP:0012345)1.93380299
129Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.93380299
130Abnormal protein N-linked glycosylation (HP:0012347)1.93380299
131Abnormality of B cell number (HP:0010975)1.91581654
132Cerebral hemorrhage (HP:0001342)1.89855634
133Abnormality of macrophages (HP:0004311)1.88695285
134Progressive neurologic deterioration (HP:0002344)1.87757950
135Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.87005563
136Patchy hypopigmentation of hair (HP:0011365)1.81531194
137Abnormality of urine glucose concentration (HP:0011016)1.78651617
138Glycosuria (HP:0003076)1.78651617
139Lethargy (HP:0001254)1.77880494
140Methylmalonic acidemia (HP:0002912)1.75929280
141Abnormality of the heme biosynthetic pathway (HP:0010472)1.75527642
142Hypoplastic pelvis (HP:0008839)1.73806172
143Hyperphosphaturia (HP:0003109)1.73759426
144IgM deficiency (HP:0002850)1.73303076
145Breast hypoplasia (HP:0003187)1.70439884
146Severe combined immunodeficiency (HP:0004430)1.69099380
147IgG deficiency (HP:0004315)1.68341838
148Gastrointestinal stroma tumor (HP:0100723)1.68290943
149Methylmalonic aciduria (HP:0012120)1.67097090
150Cerebral inclusion bodies (HP:0100314)1.65094532
151Type II lissencephaly (HP:0007260)1.63670701
152Recurrent abscess formation (HP:0002722)1.63565126
153Supranuclear gaze palsy (HP:0000605)1.61500293
154Stridor (HP:0010307)1.58953765
155Aplastic anemia (HP:0001915)1.57085944
156Epiphyseal stippling (HP:0010655)1.56479253
157Abnormal autonomic nervous system physiology (HP:0012332)1.54854378
158Pancytopenia (HP:0001876)1.53922011
159Blindness (HP:0000618)1.53378675
160Slow saccadic eye movements (HP:0000514)1.53249902

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.54378922
2STK393.49684987
3STK163.38453185
4TESK23.33897981
5NME22.80691016
6LIMK12.68480018
7BUB12.60537308
8OXSR12.53749395
9NME12.52266117
10CDK192.51992698
11MST42.43419602
12ARAF2.32908510
13MAP3K122.31323198
14PBK2.19694498
15TBK12.16277897
16MAP3K112.13909186
17ERN12.09142296
18BCR2.06605623
19TYK22.04368663
20PIM21.87803183
21CSNK1G31.70259761
22ADRBK21.69377600
23EIF2AK11.69030840
24MAPKAPK51.68803816
25CSK1.66753827
26PDK21.64874138
27VRK11.63703358
28WNK41.61502520
29MAP4K11.57481217
30BMPR1B1.56494133
31CASK1.54639998
32EIF2AK31.52994848
33TAOK31.46950049
34RIPK41.42468691
35KDR1.36598967
36MAP3K141.34350235
37KIT1.32022586
38TXK1.28429252
39TLK11.24567553
40JAK31.23816269
41MYLK1.22672918
42NEK61.20185266
43TNIK1.20032031
44DAPK11.19535574
45MAP3K31.18923570
46SIK31.18611732
47IRAK31.17669161
48TESK11.15961270
49CSNK1G11.12064548
50MAP2K31.08168429
51PKN11.04557058
52MAPKAPK31.04348967
53ZAP701.03991023
54TSSK61.03011390
55CSNK1G21.02636852
56CAMK2B1.00545500
57CSNK1A1L0.98085504
58DYRK20.96566757
59TAOK20.94722114
60CDK80.94672738
61NTRK10.92006482
62MARK30.90383890
63ROCK20.89921762
64ZAK0.88152882
65ABL20.87455458
66SCYL20.86238529
67HCK0.85773828
68TNK20.84662303
69TGFBR20.83837170
70CCNB10.82228236
71LCK0.78590852
72MAP4K20.78561630
73SYK0.78492328
74CAMK2G0.75318381
75TAOK10.73948434
76BRAF0.73518385
77CAMK2D0.70629616
78MATK0.69632587
79JAK10.68430574
80GRK70.68243638
81DAPK30.66484654
82CLK10.66302382
83STK240.66100300
84ILK0.65356400
85PRKCQ0.65341043
86GRK50.65271157
87CDK140.63797526
88UHMK10.63760462
89CSF1R0.63400712
90MUSK0.63237401
91MKNK10.62841104
92RPS6KA50.62814038
93IRAK40.61726204
94PIK3CA0.60862296
95FES0.60551151
96EPHB10.60140207
97PASK0.59349797
98LYN0.57622784
99ADRBK10.55588388
100PAK10.55439597
101MAP2K60.55067542
102BCKDK0.53922364
103AURKA0.53538318
104PNCK0.52838007
105BMPR20.52700424
106BLK0.52537992
107MAP3K60.52335780
108CDK180.51904076
109MAPKAPK20.50795992
110CDK150.50620880
111RAF10.50419904
112CDK11A0.49761474
113LRRK20.48709082
114PRKD20.48344358
115WEE10.48179258
116TRIM280.48087217
117STK100.48021588
118GRK60.47733124
119PAK40.47492298
120FGR0.47432624
121MAP2K70.45995462
122CAMKK20.44900276
123TEC0.44359532
124IKBKE0.42887087
125JAK20.42217807
126IKBKB0.41748761
127PIM10.41481054
128CAMK2A0.41202812
129GRK10.40048602
130PRKCE0.39262144
131CSNK2A10.38842456
132ITK0.35884068
133CSNK2A20.35868862
134BTK0.35605372
135CSNK1A10.34691593
136MAPK40.34616080
137NUAK10.34189505
138SMG10.33711972
139PRKCI0.33305611
140ACVR1B0.30806590
141FYN0.30286248
142EIF2AK20.30265634
143PRKCD0.29688655
144MAPK110.27217674
145MAP3K50.26964154
146IGF1R0.25897712

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.58585502
2Proteasome_Homo sapiens_hsa030504.45418939
3Protein export_Homo sapiens_hsa030603.99133028
4Parkinsons disease_Homo sapiens_hsa050123.84749719
5Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.57996800
6Ribosome_Homo sapiens_hsa030103.50362179
7RNA polymerase_Homo sapiens_hsa030203.33758756
8Alzheimers disease_Homo sapiens_hsa050102.81437764
9Huntingtons disease_Homo sapiens_hsa050162.61402316
10Fatty acid elongation_Homo sapiens_hsa000622.52857125
11Steroid biosynthesis_Homo sapiens_hsa001002.39399030
12Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.27244868
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.06448061
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.82478285
15SNARE interactions in vesicular transport_Homo sapiens_hsa041301.73666558
16Pyrimidine metabolism_Homo sapiens_hsa002401.68970510
17Glycosaminoglycan degradation_Homo sapiens_hsa005311.56346262
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.55760383
19Collecting duct acid secretion_Homo sapiens_hsa049661.51499364
20Ether lipid metabolism_Homo sapiens_hsa005651.48720825
21Staphylococcus aureus infection_Homo sapiens_hsa051501.48339954
22Leishmaniasis_Homo sapiens_hsa051401.40614079
23Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.40318621
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.40112583
25Basal transcription factors_Homo sapiens_hsa030221.36369219
26Sulfur metabolism_Homo sapiens_hsa009201.35537973
27Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.33518241
28Folate biosynthesis_Homo sapiens_hsa007901.33079206
29Mismatch repair_Homo sapiens_hsa034301.32004827
30RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.26373396
31Osteoclast differentiation_Homo sapiens_hsa043801.23350107
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.23338431
33Vibrio cholerae infection_Homo sapiens_hsa051101.22658647
34Vitamin B6 metabolism_Homo sapiens_hsa007501.19429210
35Viral myocarditis_Homo sapiens_hsa054161.19390250
36Primary immunodeficiency_Homo sapiens_hsa053401.17460637
37Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.13363189
38Herpes simplex infection_Homo sapiens_hsa051681.12722970
39Non-homologous end-joining_Homo sapiens_hsa034501.12524005
40DNA replication_Homo sapiens_hsa030301.11722817
41Nucleotide excision repair_Homo sapiens_hsa034201.11195243
42Allograft rejection_Homo sapiens_hsa053301.11150797
43Cardiac muscle contraction_Homo sapiens_hsa042601.11056245
44Sphingolipid metabolism_Homo sapiens_hsa006001.09878215
45Homologous recombination_Homo sapiens_hsa034401.06753337
46Measles_Homo sapiens_hsa051621.04741436
47Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.04407264
48Tuberculosis_Homo sapiens_hsa051521.04062596
49Glutathione metabolism_Homo sapiens_hsa004801.01943427
50Rheumatoid arthritis_Homo sapiens_hsa053231.01252106
51Purine metabolism_Homo sapiens_hsa002300.97882711
52NOD-like receptor signaling pathway_Homo sapiens_hsa046210.97517996
53T cell receptor signaling pathway_Homo sapiens_hsa046600.96770804
54Spliceosome_Homo sapiens_hsa030400.95602545
55Toll-like receptor signaling pathway_Homo sapiens_hsa046200.93283236
56Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.93010166
57Sulfur relay system_Homo sapiens_hsa041220.92797556
58Autoimmune thyroid disease_Homo sapiens_hsa053200.88307406
59Histidine metabolism_Homo sapiens_hsa003400.87486691
60Metabolic pathways_Homo sapiens_hsa011000.87364878
61Galactose metabolism_Homo sapiens_hsa000520.85675168
62Arachidonic acid metabolism_Homo sapiens_hsa005900.81900851
63Other glycan degradation_Homo sapiens_hsa005110.80136941
64Base excision repair_Homo sapiens_hsa034100.79791361
65Fructose and mannose metabolism_Homo sapiens_hsa000510.78766139
66Regulation of autophagy_Homo sapiens_hsa041400.78350238
67Intestinal immune network for IgA production_Homo sapiens_hsa046720.77555500
68Pyruvate metabolism_Homo sapiens_hsa006200.77229626
69Primary bile acid biosynthesis_Homo sapiens_hsa001200.76915810
70Drug metabolism - other enzymes_Homo sapiens_hsa009830.76437175
71Linoleic acid metabolism_Homo sapiens_hsa005910.75516037
72Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.75273866
73Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.69568969
74Influenza A_Homo sapiens_hsa051640.68139654
75Phagosome_Homo sapiens_hsa041450.65737414
76Asthma_Homo sapiens_hsa053100.61838990
77Lysosome_Homo sapiens_hsa041420.59441696
78Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.58962871
79Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58637009
80Graft-versus-host disease_Homo sapiens_hsa053320.57304849
81Toxoplasmosis_Homo sapiens_hsa051450.55869384
82Jak-STAT signaling pathway_Homo sapiens_hsa046300.54366343
83Peroxisome_Homo sapiens_hsa041460.54043691
84Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.52924308
85Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.52794862
86TNF signaling pathway_Homo sapiens_hsa046680.52177279
87Systemic lupus erythematosus_Homo sapiens_hsa053220.51823373
88Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50954643
89Apoptosis_Homo sapiens_hsa042100.49210902
90Synaptic vesicle cycle_Homo sapiens_hsa047210.48880173
91Shigellosis_Homo sapiens_hsa051310.48695985
92Pentose phosphate pathway_Homo sapiens_hsa000300.48658094
93alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.48588332
94Malaria_Homo sapiens_hsa051440.47453525
95Epstein-Barr virus infection_Homo sapiens_hsa051690.47340025
96RNA degradation_Homo sapiens_hsa030180.47243884
97Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.45285086
98Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44423895
99RNA transport_Homo sapiens_hsa030130.44253418
100Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.43487937
101Chemical carcinogenesis_Homo sapiens_hsa052040.42796110
102Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.42761716
103Hematopoietic cell lineage_Homo sapiens_hsa046400.41211321
104Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.39967710
105Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39163625
106Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.38547298
107Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.38305893
108Serotonergic synapse_Homo sapiens_hsa047260.38191099
109Butanoate metabolism_Homo sapiens_hsa006500.37759471
110N-Glycan biosynthesis_Homo sapiens_hsa005100.37682809
111Arginine and proline metabolism_Homo sapiens_hsa003300.36555676
112Cysteine and methionine metabolism_Homo sapiens_hsa002700.36390474
113Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.35182709
114Fatty acid metabolism_Homo sapiens_hsa012120.33931890
1152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.33572350
116HTLV-I infection_Homo sapiens_hsa051660.33265890
117Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.32903294
118African trypanosomiasis_Homo sapiens_hsa051430.32389305
119Type I diabetes mellitus_Homo sapiens_hsa049400.29852242
120Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.27537916
121Antigen processing and presentation_Homo sapiens_hsa046120.27382285
122Propanoate metabolism_Homo sapiens_hsa006400.25722457
123Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.24219218
124Pertussis_Homo sapiens_hsa051330.23635954
125Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.21530529
126Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.17468075
127Carbon metabolism_Homo sapiens_hsa012000.17366763
128Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.16662022
129Tyrosine metabolism_Homo sapiens_hsa003500.16476482
130Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.13924311
131Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.13813812
132Legionellosis_Homo sapiens_hsa051340.12546268
133Salmonella infection_Homo sapiens_hsa051320.12032900
134Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.11981924
135Cyanoamino acid metabolism_Homo sapiens_hsa004600.11610465

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