Rank | Gene Set | Z-score |
---|---|---|
1 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222) | 7.16766354 |
2 | L-phenylalanine catabolic process (GO:0006559) | 7.16766354 |
3 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221) | 6.82685588 |
4 | L-phenylalanine metabolic process (GO:0006558) | 6.82685588 |
5 | aromatic amino acid family catabolic process (GO:0009074) | 6.32549357 |
6 | glyoxylate metabolic process (GO:0046487) | 5.68215541 |
7 | triglyceride-rich lipoprotein particle remodeling (GO:0034370) | 5.58449459 |
8 | indole-containing compound catabolic process (GO:0042436) | 5.57754377 |
9 | indolalkylamine catabolic process (GO:0046218) | 5.57754377 |
10 | tryptophan catabolic process (GO:0006569) | 5.57754377 |
11 | omega-hydroxylase P450 pathway (GO:0097267) | 5.57740426 |
12 | bile acid biosynthetic process (GO:0006699) | 5.49818506 |
13 | cysteine metabolic process (GO:0006534) | 5.37719792 |
14 | tryptophan metabolic process (GO:0006568) | 5.27531545 |
15 | kynurenine metabolic process (GO:0070189) | 5.23250901 |
16 | sulfur amino acid catabolic process (GO:0000098) | 5.08031130 |
17 | alpha-linolenic acid metabolic process (GO:0036109) | 4.99395332 |
18 | ethanol metabolic process (GO:0006067) | 4.93022459 |
19 | high-density lipoprotein particle remodeling (GO:0034375) | 4.85122195 |
20 | protein carboxylation (GO:0018214) | 4.78313224 |
21 | peptidyl-glutamic acid carboxylation (GO:0017187) | 4.78313224 |
22 | fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540) | 4.76993364 |
23 | urea cycle (GO:0000050) | 4.75628967 |
24 | urea metabolic process (GO:0019627) | 4.75628967 |
25 | aldehyde catabolic process (GO:0046185) | 4.72444565 |
26 | negative regulation of fibrinolysis (GO:0051918) | 4.67118219 |
27 | complement activation, alternative pathway (GO:0006957) | 4.66629501 |
28 | aromatic amino acid family metabolic process (GO:0009072) | 4.64375283 |
29 | oxidative demethylation (GO:0070989) | 4.63841891 |
30 | bile acid metabolic process (GO:0008206) | 4.62607661 |
31 | tyrosine metabolic process (GO:0006570) | 4.58263339 |
32 | regulation of fibrinolysis (GO:0051917) | 4.58023273 |
33 | cellular glucuronidation (GO:0052695) | 4.56196648 |
34 | phenylpropanoid metabolic process (GO:0009698) | 4.55663425 |
35 | primary alcohol catabolic process (GO:0034310) | 4.53297927 |
36 | regulation of protein activation cascade (GO:2000257) | 4.51805056 |
37 | serine family amino acid catabolic process (GO:0009071) | 4.49127147 |
38 | nitrogen cycle metabolic process (GO:0071941) | 4.44249122 |
39 | regulation of cholesterol esterification (GO:0010872) | 4.43034524 |
40 | glucuronate metabolic process (GO:0019585) | 4.41911287 |
41 | uronic acid metabolic process (GO:0006063) | 4.41911287 |
42 | homocysteine metabolic process (GO:0050667) | 4.39705606 |
43 | regulation of triglyceride catabolic process (GO:0010896) | 4.38532035 |
44 | amino-acid betaine metabolic process (GO:0006577) | 4.32754415 |
45 | lysine metabolic process (GO:0006553) | 4.25528970 |
46 | lysine catabolic process (GO:0006554) | 4.25528970 |
47 | regulation of complement activation (GO:0030449) | 4.24629596 |
48 | reverse cholesterol transport (GO:0043691) | 4.23510570 |
49 | cellular ketone body metabolic process (GO:0046950) | 4.22275975 |
50 | plasma lipoprotein particle clearance (GO:0034381) | 4.22119523 |
51 | blood coagulation, intrinsic pathway (GO:0007597) | 4.21499666 |
52 | ethanol oxidation (GO:0006069) | 4.20724556 |
53 | alpha-amino acid catabolic process (GO:1901606) | 4.19285617 |
54 | protein-lipid complex remodeling (GO:0034368) | 4.18372615 |
55 | macromolecular complex remodeling (GO:0034367) | 4.18372615 |
56 | plasma lipoprotein particle remodeling (GO:0034369) | 4.18372615 |
57 | benzene-containing compound metabolic process (GO:0042537) | 4.13314152 |
58 | triglyceride homeostasis (GO:0070328) | 4.09128572 |
59 | acylglycerol homeostasis (GO:0055090) | 4.09128572 |
60 | drug catabolic process (GO:0042737) | 4.08652868 |
61 | amine catabolic process (GO:0009310) | 4.04100974 |
62 | cellular biogenic amine catabolic process (GO:0042402) | 4.04100974 |
63 | phospholipid efflux (GO:0033700) | 4.03427420 |
64 | response to nitrosative stress (GO:0051409) | 4.03349459 |
65 | daunorubicin metabolic process (GO:0044597) | 4.02536965 |
66 | polyketide metabolic process (GO:0030638) | 4.02536965 |
67 | doxorubicin metabolic process (GO:0044598) | 4.02536965 |
68 | indolalkylamine metabolic process (GO:0006586) | 4.00609719 |
69 | intestinal cholesterol absorption (GO:0030299) | 3.98248685 |
70 | coenzyme catabolic process (GO:0009109) | 3.96114504 |
71 | cellular amino acid catabolic process (GO:0009063) | 3.93588774 |
72 | serine family amino acid metabolic process (GO:0009069) | 3.91562730 |
73 | short-chain fatty acid metabolic process (GO:0046459) | 3.90371678 |
74 | negative regulation of sterol transport (GO:0032372) | 3.89570699 |
75 | negative regulation of cholesterol transport (GO:0032375) | 3.89570699 |
76 | drug transmembrane transport (GO:0006855) | 3.84127739 |
77 | S-adenosylmethionine metabolic process (GO:0046500) | 3.82443357 |
78 | cofactor catabolic process (GO:0051187) | 3.81484660 |
79 | cholesterol efflux (GO:0033344) | 3.79807137 |
80 | primary alcohol metabolic process (GO:0034308) | 3.79649555 |
81 | negative regulation of protein activation cascade (GO:2000258) | 3.79301836 |
82 | acetyl-CoA metabolic process (GO:0006084) | 3.77375671 |
83 | fibrinolysis (GO:0042730) | 3.75603770 |
84 | bile acid and bile salt transport (GO:0015721) | 3.75226718 |
85 | xenobiotic catabolic process (GO:0042178) | 3.74481955 |
86 | ketone body metabolic process (GO:1902224) | 3.73691407 |
87 | urate metabolic process (GO:0046415) | 3.73480076 |
88 | heme transport (GO:0015886) | 3.72343202 |
89 | serine family amino acid biosynthetic process (GO:0009070) | 3.71922425 |
90 | glutamate metabolic process (GO:0006536) | 3.69283583 |
91 | exogenous drug catabolic process (GO:0042738) | 3.66670162 |
92 | cellular modified amino acid catabolic process (GO:0042219) | 3.66487263 |
93 | aminoglycoside antibiotic metabolic process (GO:0030647) | 3.66159942 |
94 | flavonoid metabolic process (GO:0009812) | 3.62760032 |
95 | organic acid catabolic process (GO:0016054) | 3.62728951 |
96 | carboxylic acid catabolic process (GO:0046395) | 3.62728951 |
97 | glycine metabolic process (GO:0006544) | 3.61996026 |
98 | positive regulation of triglyceride lipase activity (GO:0061365) | 3.61971810 |
99 | positive regulation of lipoprotein lipase activity (GO:0051006) | 3.61971810 |
100 | negative regulation of lipase activity (GO:0060192) | 3.60629138 |
101 | protein activation cascade (GO:0072376) | 3.60119494 |
102 | arginine metabolic process (GO:0006525) | 3.56738701 |
103 | regulation of plasminogen activation (GO:0010755) | 3.56675512 |
104 | xenobiotic metabolic process (GO:0006805) | 3.56278370 |
105 | imidazole-containing compound metabolic process (GO:0052803) | 3.54638013 |
106 | very-low-density lipoprotein particle assembly (GO:0034379) | 3.54327276 |
107 | drug metabolic process (GO:0017144) | 3.54068925 |
108 | fatty acid beta-oxidation (GO:0006635) | 3.53981382 |
109 | low-density lipoprotein particle remodeling (GO:0034374) | 3.53910017 |
110 | fatty acid oxidation (GO:0019395) | 3.53293907 |
111 | monocarboxylic acid catabolic process (GO:0072329) | 3.52995118 |
112 | plasma lipoprotein particle assembly (GO:0034377) | 3.51003395 |
113 | cholesterol homeostasis (GO:0042632) | 3.48754521 |
114 | very long-chain fatty acid metabolic process (GO:0000038) | 3.47653948 |
115 | negative regulation of blood coagulation (GO:0030195) | 3.47648254 |
116 | negative regulation of hemostasis (GO:1900047) | 3.47648254 |
117 | lipid oxidation (GO:0034440) | 3.47307531 |
118 | epoxygenase P450 pathway (GO:0019373) | 3.46411193 |
119 | opsonization (GO:0008228) | 3.45463452 |
120 | sterol homeostasis (GO:0055092) | 3.43621835 |
121 | alkaloid metabolic process (GO:0009820) | 3.42603223 |
122 | complement activation (GO:0006956) | 3.41023548 |
123 | complement activation, classical pathway (GO:0006958) | 3.40868923 |
124 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.36587273 |
125 | acute-phase response (GO:0006953) | 3.35235328 |
126 | negative regulation of complement activation (GO:0045916) | 3.32876552 |
127 | vitamin biosynthetic process (GO:0009110) | 3.29062933 |
128 | negative regulation of coagulation (GO:0050819) | 3.26596762 |
129 | fat-soluble vitamin biosynthetic process (GO:0042362) | 3.21538592 |
130 | hormone catabolic process (GO:0042447) | 3.19895298 |
131 | regulation of humoral immune response (GO:0002920) | 3.19119761 |
132 | negative regulation of wound healing (GO:0061045) | 3.08359911 |
133 | intestinal absorption (GO:0050892) | 3.07784027 |
Rank | Gene Set | Z-score |
---|---|---|
1 | RXR_22158963_ChIP-Seq_LIVER_Mouse | 7.52250473 |
2 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 6.58688538 |
3 | PPARA_22158963_ChIP-Seq_LIVER_Mouse | 6.39305447 |
4 | LXR_22158963_ChIP-Seq_LIVER_Mouse | 5.88792059 |
5 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 5.23517113 |
6 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 4.80423404 |
7 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 4.79167567 |
8 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 3.76704330 |
9 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 3.34994490 |
10 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.24339559 |
11 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 2.14790371 |
12 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.12028908 |
13 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 10.6485317 |
14 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 1.97793891 |
15 | VDR_22108803_ChIP-Seq_LS180_Human | 1.89181169 |
16 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 1.83548769 |
17 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 1.83149534 |
18 | TCF7L2_21901280_ChIP-Seq_H4IIE_Rat | 1.76066748 |
19 | CLOCK_20551151_ChIP-Seq_293T_Human | 1.64522191 |
20 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.58836713 |
21 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 1.50928348 |
22 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 1.49952827 |
23 | HTT_18923047_ChIP-ChIP_STHdh_Human | 1.46127102 |
24 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 1.40322272 |
25 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.37074776 |
26 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.33203494 |
27 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.33203494 |
28 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.30003413 |
29 | FOXA2_19822575_ChIP-Seq_HepG2_Human | 1.28697417 |
30 | GATA1_22025678_ChIP-Seq_K562_Human | 1.26182510 |
31 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 1.24778993 |
32 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.24616564 |
33 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.20420926 |
34 | * HNF4A_19822575_ChIP-Seq_HepG2_Human | 1.19050983 |
35 | ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 1.18876590 |
36 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.17321416 |
37 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 1.16721536 |
38 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.16624630 |
39 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.16624630 |
40 | TCF4_22108803_ChIP-Seq_LS180_Human | 1.15375646 |
41 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.15372042 |
42 | NRF2_20460467_ChIP-Seq_MEFs_Mouse | 1.14344634 |
43 | NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 1.14344634 |
44 | * AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.14135688 |
45 | SOX2_27498859_Chip-Seq_STOMACH_Mouse | 1.13965401 |
46 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 1.13117733 |
47 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.12255758 |
48 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.11143728 |
49 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.10965115 |
50 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.10936397 |
51 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.10823906 |
52 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.10504968 |
53 | PHF8_20622853_ChIP-Seq_HELA_Human | 1.10061913 |
54 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.09367990 |
55 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.08057750 |
56 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 1.08014068 |
57 | CDX2_21074721_ChIP-Seq_CACO-2_Mouse | 1.07853698 |
58 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.07435124 |
59 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.07023050 |
60 | GATA4_25053715_ChIP-Seq_YYC3_Human | 1.06887348 |
61 | * RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 1.05756414 |
62 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.05243943 |
63 | HNFA_21074721_ChIP-Seq_CACO-2_Human | 1.03303016 |
64 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.02464156 |
65 | ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 1.01414479 |
66 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 1.00982360 |
67 | FOXM1_26456572_ChIP-Seq_MCF-7_Human | 1.00518787 |
68 | NCOR_22424771_ChIP-Seq_293T_Human | 0.99292096 |
69 | GATA6_21074721_ChIP-Seq_CACO-2_Mouse | 0.97440381 |
70 | RXRA_24833708_ChIP-Seq_LIVER_Mouse | 0.97360488 |
71 | ETV1_20927104_ChIP-Seq_GIST48_Human | 0.96769520 |
72 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 0.95998700 |
73 | P300_19829295_ChIP-Seq_ESCs_Human | 0.95348050 |
74 | PCGF4_22325352_ChIP-Seq_293T-Rex_Human | 0.94033708 |
75 | RBPJ_21746931_ChIP-Seq_IB4_Human | 0.93889130 |
76 | GATA6_21074721_ChIP-Seq_CACO-2_Human | 0.93431314 |
77 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 0.93216870 |
78 | IGF1R_20145208_ChIP-Seq_DFB_Human | 0.92337036 |
79 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 0.92280741 |
80 | GATA6_25053715_ChIP-Seq_YYC3_Human | 0.91484875 |
81 | CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 0.89961981 |
82 | P53_21459846_ChIP-Seq_SAOS-2_Human | 0.88505965 |
83 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 0.88053484 |
84 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 0.86670496 |
85 | NFYA_21822215_ChIP-Seq_K562_Human | 0.85780740 |
86 | SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse | 0.85658691 |
87 | SALL4_18804426_ChIP-ChIP_XEN_Mouse | 0.85505627 |
88 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 0.85016641 |
89 | KAP1_22055183_ChIP-Seq_ESCs_Mouse | 0.84508368 |
90 | CBP_20019798_ChIP-Seq_JUKART_Human | 0.83575917 |
91 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 0.83575917 |
92 | STAT3_18555785_Chip-Seq_ESCs_Mouse | 0.82973517 |
93 | * SOX2_20726797_ChIP-Seq_SW620_Human | 0.82454797 |
94 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 0.82336033 |
95 | NANOG_20526341_ChIP-Seq_ESCs_Human | 0.82312099 |
96 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.79649049 |
97 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 0.77544069 |
98 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 0.77404926 |
99 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 0.75845228 |
100 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 0.73236737 |
101 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 0.72996713 |
102 | FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human | 0.72029223 |
103 | RAD21_21589869_ChIP-Seq_MESCs_Mouse | 0.71678877 |
104 | BMI1_19503595_ChIP-Seq_MEFsC_Mouse | 0.70715692 |
105 | EGR1_19032775_ChIP-ChIP_M12_Human | 0.70307429 |
106 | FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 0.70057648 |
107 | PPARG_20887899_ChIP-Seq_3T3-L1_Mouse | 0.69821742 |
108 | * AR_21915096_ChIP-Seq_LNCaP-1F5_Human | 0.68610202 |
109 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 0.68512009 |
110 | AR_20517297_ChIP-Seq_VCAP_Human | 0.68274655 |
111 | CDX2_20551321_ChIP-Seq_CACO-2_Human | 0.67862281 |
112 | * ESR2_21235772_ChIP-Seq_MCF-7_Human | 0.67513240 |
113 | CEBPB_22108803_ChIP-Seq_LS180_Human | 0.65479226 |
114 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 0.64706017 |
115 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 0.64125543 |
116 | TAF15_26573619_Chip-Seq_HEK293_Human | 0.63239017 |
117 | PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 0.62376950 |
118 | FOXA1_25552417_ChIP-Seq_VCAP_Human | 0.61267980 |
119 | PPAR_26484153_Chip-Seq_NCI-H1993_Human | 0.60385134 |
120 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.60287858 |
121 | MYC_19915707_ChIP-ChIP_AK7_Human | 0.58831948 |
122 | FOXO3_23340844_ChIP-Seq_DLD1_Human | 0.58567555 |
123 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 0.57210924 |
124 | STAT1_17558387_ChIP-Seq_HELA_Human | 0.55673507 |
125 | CBP_21632823_ChIP-Seq_H3396_Human | 0.52624789 |
126 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 0.52327678 |
127 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 0.51088101 |
128 | ESET_19884257_ChIP-Seq_ESCs_Mouse | 0.50712390 |
129 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 0.50658583 |
130 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 0.50325050 |
131 | P63_26484246_Chip-Seq_KERATINOCYTES_Human | 0.50302456 |
132 | SREBP2_21459322_ChIP-Seq_LIVER_Mouse | 0.49600752 |
133 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 0.48156172 |
134 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 0.47840120 |
135 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.47682260 |
136 | FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.47643541 |
137 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 0.47429924 |
138 | RARB_24833708_ChIP-Seq_LIVER_Mouse | 0.46826889 |
139 | RARA_24833708_ChIP-Seq_LIVER_Mouse | 0.46668820 |
140 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 0.46529810 |
141 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 0.46287834 |
142 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 0.45955410 |
143 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.45262685 |
144 | CSB_26484114_Chip-Seq_FIBROBLAST_Human | 0.45152232 |
145 | GATA3_24758297_ChIP-Seq_MCF-7_Human | 0.44073886 |
146 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.44033157 |
147 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 0.43913047 |
148 | FOXH1_21741376_ChIP-Seq_EPCs_Human | 0.43625011 |
149 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 0.43568423 |
150 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 0.43346041 |
151 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 0.42819142 |
152 | CDX2_22108803_ChIP-Seq_LS180_Human | 0.42523752 |
153 | ERG_20517297_ChIP-Seq_VCAP_Human | 0.42293364 |
154 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 0.41993086 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0002139_abnormal_hepatobiliary_system | 7.61401972 |
2 | MP0005360_urolithiasis | 7.15054469 |
3 | MP0005085_abnormal_gallbladder_physiolo | 5.73925361 |
4 | MP0005365_abnormal_bile_salt | 5.47734808 |
5 | MP0008875_abnormal_xenobiotic_pharmacok | 5.33865888 |
6 | MP0003806_abnormal_nucleotide_metabolis | 4.40850991 |
7 | MP0003252_abnormal_bile_duct | 3.44833952 |
8 | MP0010329_abnormal_lipoprotein_level | 3.23270138 |
9 | MP0003195_calcinosis | 3.03252140 |
10 | MP0005332_abnormal_amino_acid | 2.89039500 |
11 | MP0009840_abnormal_foam_cell | 2.84705275 |
12 | MP0005083_abnormal_biliary_tract | 2.83545695 |
13 | MP0004019_abnormal_vitamin_homeostasis | 2.43163142 |
14 | MP0001666_abnormal_nutrient_absorption | 2.41724410 |
15 | MP0003191_abnormal_cellular_cholesterol | 2.26763078 |
16 | MP0002138_abnormal_hepatobiliary_system | 2.12513316 |
17 | MP0003186_abnormal_redox_activity | 2.09513949 |
18 | MP0002118_abnormal_lipid_homeostasis | 2.00605597 |
19 | MP0000609_abnormal_liver_physiology | 1.92158974 |
20 | MP0005451_abnormal_body_composition | 1.75504496 |
21 | MP0005319_abnormal_enzyme/_coenzyme | 1.73241385 |
22 | MP0005584_abnormal_enzyme/coenzyme_acti | 1.63846409 |
23 | MP0001764_abnormal_homeostasis | 1.62570924 |
24 | MP0009643_abnormal_urine_homeostasis | 1.54489993 |
25 | MP0003011_delayed_dark_adaptation | 1.54186447 |
26 | MP0005408_hypopigmentation | 1.46569037 |
27 | MP0009697_abnormal_copulation | 1.46159083 |
28 | MP0003941_abnormal_skin_development | 1.45427864 |
29 | MP0003868_abnormal_feces_composition | 1.36506779 |
30 | MP0009764_decreased_sensitivity_to | 1.28977993 |
31 | MP0003656_abnormal_erythrocyte_physiolo | 1.26894453 |
32 | MP0005636_abnormal_mineral_homeostasis | 1.23312090 |
33 | MP0010386_abnormal_urinary_bladder | 1.12943149 |
34 | MP0003724_increased_susceptibility_to | 1.10183602 |
35 | MP0000604_amyloidosis | 1.08966918 |
36 | MP0002254_reproductive_system_inflammat | 1.08109537 |
37 | MP0005647_abnormal_sex_gland | 1.07253526 |
38 | MP0003690_abnormal_glial_cell | 1.06890046 |
39 | MP0009763_increased_sensitivity_to | 1.03670305 |
40 | MP0000598_abnormal_liver_morphology | 1.03537325 |
41 | MP0008469_abnormal_protein_level | 1.01397012 |
42 | MP0002876_abnormal_thyroid_physiology | 1.01020310 |
43 | MP0005084_abnormal_gallbladder_morpholo | 0.96861967 |
44 | MP0006036_abnormal_mitochondrial_physio | 0.93802485 |
45 | MP0009765_abnormal_xenobiotic_induced | 0.90001956 |
46 | MP0002909_abnormal_adrenal_gland | 0.88529866 |
47 | MP0005670_abnormal_white_adipose | 0.83933118 |
48 | MP0005376_homeostasis/metabolism_phenot | 0.83513066 |
49 | MP0009642_abnormal_blood_homeostasis | 0.83505736 |
50 | MP0001756_abnormal_urination | 0.83351460 |
51 | MP0010368_abnormal_lymphatic_system | 0.81698043 |
52 | MP0004043_abnormal_pH_regulation | 0.81381749 |
53 | MP0005058_abnormal_lysosome_morphology | 0.80268925 |
54 | MP0001661_extended_life_span | 0.80124290 |
55 | MP0004381_abnormal_hair_follicle | 0.78777287 |
56 | MP0002136_abnormal_kidney_physiology | 0.76341969 |
57 | MP0005535_abnormal_body_temperature | 0.74555395 |
58 | MP0006082_CNS_inflammation | 0.74051027 |
59 | MP0005551_abnormal_eye_electrophysiolog | 0.74039553 |
60 | MP0004782_abnormal_surfactant_physiolog | 0.73237336 |
61 | MP0002638_abnormal_pupillary_reflex | 0.73183067 |
62 | MP0002282_abnormal_trachea_morphology | 0.69290750 |
63 | MP0002132_abnormal_respiratory_system | 0.66777693 |
64 | MP0003953_abnormal_hormone_level | 0.66579885 |
65 | MP0002971_abnormal_brown_adipose | 0.66386200 |
66 | MP0003436_decreased_susceptibility_to | 0.66316655 |
67 | MP0005334_abnormal_fat_pad | 0.65677416 |
68 | MP0009780_abnormal_chondrocyte_physiolo | 0.65342585 |
69 | MP0001485_abnormal_pinna_reflex | 0.64435888 |
70 | MP0004147_increased_porphyrin_level | 0.62022712 |
71 | MP0002078_abnormal_glucose_homeostasis | 0.60221343 |
72 | MP0003329_amyloid_beta_deposits | 0.59908879 |
73 | MP0002938_white_spotting | 0.59626251 |
74 | MP0003705_abnormal_hypodermis_morpholog | 0.59422901 |
75 | MP0005266_abnormal_metabolism | 0.59420914 |
76 | MP0002796_impaired_skin_barrier | 0.58988506 |
77 | MP0004130_abnormal_muscle_cell | 0.57612442 |
78 | MP0003718_maternal_effect | 0.56908838 |
79 | MP0002277_abnormal_respiratory_mucosa | 0.56766644 |
80 | MP0005164_abnormal_response_to | 0.55662680 |
81 | MP0005395_other_phenotype | 0.55578716 |
82 | MP0002295_abnormal_pulmonary_circulatio | 0.55275351 |
83 | MP0005220_abnormal_exocrine_pancreas | 0.55254295 |
84 | MP0003638_abnormal_response/metabolism_ | 0.55153969 |
85 | MP0001984_abnormal_olfaction | 0.54944269 |
86 | MP0003075_altered_response_to | 0.54192644 |
87 | MP0000538_abnormal_urinary_bladder | 0.54081442 |
88 | MP0005464_abnormal_platelet_physiology | 0.53604437 |
89 | MP0009379_abnormal_foot_pigmentation | 0.53344197 |
90 | MP0003879_abnormal_hair_cell | 0.53230487 |
91 | MP0009785_altered_susceptibility_to | 0.52501216 |
92 | MP0000920_abnormal_myelination | 0.52036638 |
93 | MP0005645_abnormal_hypothalamus_physiol | 0.51577382 |
94 | MP0005379_endocrine/exocrine_gland_phen | 0.49806819 |
95 | MP0008873_increased_physiological_sensi | 0.49304003 |
96 | MP0001944_abnormal_pancreas_morphology | 0.48797389 |
97 | MP0004133_heterotaxia | 0.48682021 |
98 | MP0005166_decreased_susceptibility_to | 0.47838078 |
99 | MP0002090_abnormal_vision | 0.47815426 |
100 | MP0001853_heart_inflammation | 0.47017405 |
101 | MP0005666_abnormal_adipose_tissue | 0.46922860 |
102 | MP0009115_abnormal_fat_cell | 0.46530868 |
103 | MP0009053_abnormal_anal_canal | 0.46440589 |
104 | MP0006035_abnormal_mitochondrial_morpho | 0.46379299 |
105 | MP0001845_abnormal_inflammatory_respons | 0.44669999 |
106 | MP0003950_abnormal_plasma_membrane | 0.43239207 |
107 | MP0005410_abnormal_fertilization | 0.42206003 |
108 | MP0000230_abnormal_systemic_arterial | 0.41462260 |
109 | MP0005187_abnormal_penis_morphology | 0.41241585 |
110 | MP0000639_abnormal_adrenal_gland | 0.41027022 |
111 | MP0002970_abnormal_white_adipose | 0.40645361 |
112 | MP0004883_abnormal_blood_vessel | 0.40546002 |
113 | MP0002419_abnormal_innate_immunity | 0.40519394 |
114 | MP0008874_decreased_physiological_sensi | 0.40353528 |
115 | MP0000566_synostosis | 0.40333715 |
116 | MP0005448_abnormal_energy_balance | 0.39850873 |
117 | MP0001765_abnormal_ion_homeostasis | 0.39716084 |
118 | MP0000249_abnormal_blood_vessel | 0.39508756 |
119 | MP0003453_abnormal_keratinocyte_physiol | 0.39388898 |
120 | MP0008872_abnormal_physiological_respon | 0.38788237 |
121 | MP0005025_abnormal_response_to | 0.38160147 |
122 | MP0003959_abnormal_lean_body | 0.37252062 |
123 | MP0002168_other_aberrant_phenotype | 0.37122886 |
124 | MP0002928_abnormal_bile_duct | 0.36978620 |
125 | MP0001881_abnormal_mammary_gland | 0.36266758 |
126 | MP0005248_abnormal_Harderian_gland | 0.36212562 |
127 | MP0005377_hearing/vestibular/ear_phenot | 0.36052997 |
128 | MP0003878_abnormal_ear_physiology | 0.36052997 |
129 | MP0008995_early_reproductive_senescence | 0.35708140 |
130 | MP0003890_abnormal_embryonic-extraembry | 0.35694505 |
131 | MP0001324_abnormal_eye_pigmentation | 0.34929349 |
132 | MP0005646_abnormal_pituitary_gland | 0.33488729 |
133 | MP0002160_abnormal_reproductive_system | 0.33056735 |
134 | MP0001664_abnormal_digestion | 0.32913990 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 6.83207865 |
2 | Intrahepatic cholestasis (HP:0001406) | 6.51600004 |
3 | Deep venous thrombosis (HP:0002625) | 6.26739622 |
4 | Xanthomatosis (HP:0000991) | 5.73080444 |
5 | Abnormality of monocarboxylic acid metabolism (HP:0010996) | 5.69893994 |
6 | Prolonged partial thromboplastin time (HP:0003645) | 5.69561725 |
7 | Hypobetalipoproteinemia (HP:0003563) | 5.51479013 |
8 | Hyperlipoproteinemia (HP:0010980) | 5.03127706 |
9 | Complement deficiency (HP:0004431) | 4.56756556 |
10 | Hyperammonemia (HP:0001987) | 4.25984076 |
11 | Joint hemorrhage (HP:0005261) | 4.23729543 |
12 | Abnormality of glutamine family amino acid metabolism (HP:0010902) | 4.23695311 |
13 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 4.10002415 |
14 | Hypolipoproteinemia (HP:0010981) | 4.08338759 |
15 | Hyperglycinuria (HP:0003108) | 4.07552580 |
16 | Hyperglycinemia (HP:0002154) | 4.06238722 |
17 | Epidermoid cyst (HP:0200040) | 4.01965241 |
18 | Abnormality of glycine metabolism (HP:0010895) | 4.01820503 |
19 | Abnormality of serine family amino acid metabolism (HP:0010894) | 4.01820503 |
20 | Ketosis (HP:0001946) | 3.95229379 |
21 | Abnormality of methionine metabolism (HP:0010901) | 3.91086556 |
22 | Fat malabsorption (HP:0002630) | 3.90865934 |
23 | Abnormality of the level of lipoprotein cholesterol (HP:0010979) | 3.89202112 |
24 | Abnormality of sulfur amino acid metabolism (HP:0004339) | 3.82095228 |
25 | Abnormality of the common coagulation pathway (HP:0010990) | 3.75775626 |
26 | Abnormality of fatty-acid metabolism (HP:0004359) | 3.56750695 |
27 | Hypoalphalipoproteinemia (HP:0003233) | 3.49561846 |
28 | Conjugated hyperbilirubinemia (HP:0002908) | 3.44695503 |
29 | Hypercholesterolemia (HP:0003124) | 3.35606607 |
30 | Abnormality of complement system (HP:0005339) | 3.34429332 |
31 | Hypoglycemic coma (HP:0001325) | 3.33305595 |
32 | Abnormality of long-chain fatty-acid metabolism (HP:0010964) | 3.19040365 |
33 | Steatorrhea (HP:0002570) | 3.14468754 |
34 | Abnormality of the intrinsic pathway (HP:0010989) | 3.14367050 |
35 | Abnormality of pyrimidine metabolism (HP:0004353) | 3.13196193 |
36 | Delayed CNS myelination (HP:0002188) | 3.08283871 |
37 | Hyperbilirubinemia (HP:0002904) | 3.00739961 |
38 | Abnormality of nucleobase metabolism (HP:0010932) | 3.00172356 |
39 | Ketoacidosis (HP:0001993) | 2.95246178 |
40 | Abnormality of serum amino acid levels (HP:0003112) | 2.95234137 |
41 | Abnormality of purine metabolism (HP:0004352) | 2.93660438 |
42 | Systemic lupus erythematosus (HP:0002725) | 2.90178954 |
43 | Lethargy (HP:0001254) | 2.89054381 |
44 | Metabolic acidosis (HP:0001942) | 2.87964392 |
45 | Cerebral edema (HP:0002181) | 2.87170590 |
46 | Vascular calcification (HP:0004934) | 2.78080293 |
47 | Hepatocellular carcinoma (HP:0001402) | 2.76511027 |
48 | Nephritis (HP:0000123) | 2.75718158 |
49 | Dicarboxylic aciduria (HP:0003215) | 2.74938846 |
50 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.74938846 |
51 | Gout (HP:0001997) | 2.66223268 |
52 | Generalized aminoaciduria (HP:0002909) | 2.65237367 |
53 | Reduced antithrombin III activity (HP:0001976) | 2.64027892 |
54 | Myocardial infarction (HP:0001658) | 2.57969277 |
55 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 2.54724317 |
56 | Glycosuria (HP:0003076) | 2.51154100 |
57 | Abnormality of urine glucose concentration (HP:0011016) | 2.51154100 |
58 | Acute necrotizing encephalopathy (HP:0006965) | 2.49438519 |
59 | Spontaneous abortion (HP:0005268) | 2.47786973 |
60 | Cardiovascular calcification (HP:0011915) | 2.45022262 |
61 | Proximal tubulopathy (HP:0000114) | 2.41600893 |
62 | Vomiting (HP:0002013) | 2.41174794 |
63 | Recurrent gram-negative bacterial infections (HP:0005420) | 2.38981989 |
64 | Abnormal urine phosphate concentration (HP:0012599) | 2.37891788 |
65 | Amyloidosis (HP:0011034) | 2.37434894 |
66 | Alkalosis (HP:0001948) | 2.35568796 |
67 | Abnormal biliary tract physiology (HP:0012439) | 2.33221667 |
68 | Bile duct proliferation (HP:0001408) | 2.33221667 |
69 | Glomerulonephritis (HP:0000099) | 2.30138613 |
70 | Irritability (HP:0000737) | 2.28824492 |
71 | Malnutrition (HP:0004395) | 2.28371407 |
72 | Skin nodule (HP:0200036) | 2.28302909 |
73 | Abnormal respiratory epithelium morphology (HP:0012253) | 2.27546821 |
74 | Abnormal respiratory motile cilium morphology (HP:0005938) | 2.27546821 |
75 | Potter facies (HP:0002009) | 2.25733251 |
76 | Facial shape deformation (HP:0011334) | 2.25733251 |
77 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 2.25579494 |
78 | Absent/shortened dynein arms (HP:0200106) | 2.25579494 |
79 | Rickets (HP:0002748) | 2.24903065 |
80 | Pancreatitis (HP:0001733) | 2.24534937 |
81 | Chronic bronchitis (HP:0004469) | 2.23447316 |
82 | Rhinitis (HP:0012384) | 2.23383964 |
83 | Hydroxyprolinuria (HP:0003080) | 2.21561652 |
84 | Abnormality of proline metabolism (HP:0010907) | 2.21561652 |
85 | Hypochromic microcytic anemia (HP:0004840) | 2.21481119 |
86 | Hypophosphatemic rickets (HP:0004912) | 2.20373311 |
87 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.19415205 |
88 | Opisthotonus (HP:0002179) | 2.18120638 |
89 | Brushfield spots (HP:0001088) | 2.17458348 |
90 | Abnormal respiratory motile cilium physiology (HP:0012261) | 2.15890623 |
91 | Abnormal gallbladder morphology (HP:0012437) | 2.15451881 |
92 | Enlarged kidneys (HP:0000105) | 2.15177690 |
93 | Spastic diplegia (HP:0001264) | 2.14275735 |
94 | Acanthocytosis (HP:0001927) | 2.13831670 |
95 | Mitochondrial inheritance (HP:0001427) | 2.13246909 |
96 | Osteomalacia (HP:0002749) | 2.12884909 |
97 | Abnormal gallbladder physiology (HP:0012438) | 2.10052736 |
98 | Cholecystitis (HP:0001082) | 2.10052736 |
99 | Hemorrhage of the eye (HP:0011885) | 2.07719139 |
100 | Megaloblastic anemia (HP:0001889) | 2.07325382 |
101 | Esophageal varix (HP:0002040) | 2.06493341 |
102 | Sensorimotor neuropathy (HP:0007141) | 2.06231586 |
103 | Renal cortical cysts (HP:0000803) | 2.04613143 |
104 | Abnormal ciliary motility (HP:0012262) | 2.04333441 |
105 | Cholelithiasis (HP:0001081) | 2.04085021 |
106 | Progressive macrocephaly (HP:0004481) | 2.03638810 |
107 | Abnormality of alanine metabolism (HP:0010916) | 2.02064018 |
108 | Hyperalaninemia (HP:0003348) | 2.02064018 |
109 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.02064018 |
110 | Increased purine levels (HP:0004368) | 2.01313211 |
111 | Hyperuricemia (HP:0002149) | 2.01313211 |
112 | Nausea (HP:0002018) | 1.99915919 |
113 | Acute encephalopathy (HP:0006846) | 1.97678297 |
114 | Abnormality of glycolysis (HP:0004366) | 1.96691845 |
115 | Increased serum pyruvate (HP:0003542) | 1.96691845 |
116 | Increased CSF lactate (HP:0002490) | 1.94620476 |
117 | Cerebral palsy (HP:0100021) | 1.94187049 |
118 | Mitral stenosis (HP:0001718) | 1.94096514 |
119 | Abnormal enzyme/coenzyme activity (HP:0012379) | 1.93492921 |
120 | Gingival bleeding (HP:0000225) | 1.92967351 |
121 | Neonatal onset (HP:0003623) | 1.91691753 |
122 | Methylmalonic acidemia (HP:0002912) | 1.91289030 |
123 | Abnormal cartilage morphology (HP:0002763) | 1.90677833 |
124 | Abnormality of vitamin B metabolism (HP:0004340) | 1.90105683 |
125 | Menorrhagia (HP:0000132) | 1.89062504 |
126 | Renal Fanconi syndrome (HP:0001994) | 1.86797643 |
127 | Hypoglycemic seizures (HP:0002173) | 1.86559656 |
128 | Hyperactive renin-angiotensin system (HP:0000841) | 1.85751129 |
129 | Abnormality of vitamin metabolism (HP:0100508) | 1.85379040 |
130 | Fair hair (HP:0002286) | 1.84936117 |
131 | Abnormality of the vitamin B12 metabolism (HP:0004341) | 1.84922992 |
132 | Hepatic necrosis (HP:0002605) | 1.84018592 |
133 | Hyperphosphaturia (HP:0003109) | 1.83014141 |
134 | Congenital, generalized hypertrichosis (HP:0004540) | 1.82088225 |
Rank | Gene Set | Z-score |
---|---|---|
1 | BCKDK | 6.22931184 |
2 | PBK | 3.79311916 |
3 | ACVR1B | 3.53443648 |
4 | FGFR4 | 3.11431114 |
5 | MST1R | 3.07967448 |
6 | ERN1 | 3.02048294 |
7 | SIK1 | 2.91949888 |
8 | MAP3K12 | 2.91136199 |
9 | STK39 | 2.67506330 |
10 | OXSR1 | 2.43276304 |
11 | BMPR1B | 2.42557375 |
12 | ERBB4 | 2.40444212 |
13 | VRK2 | 2.26860526 |
14 | WNK4 | 2.13243458 |
15 | INSRR | 2.04769904 |
16 | NME1 | 1.93593329 |
17 | ABL2 | 1.88344644 |
18 | EPHB1 | 1.86520358 |
19 | MAP3K14 | 1.81801937 |
20 | ZAK | 1.81005490 |
21 | EIF2AK3 | 1.79673720 |
22 | MET | 1.77517619 |
23 | TAOK3 | 1.77130155 |
24 | MAP4K2 | 1.72384045 |
25 | TNIK | 1.63370480 |
26 | BRSK2 | 1.62170869 |
27 | MAPKAPK3 | 1.60414666 |
28 | MST4 | 1.58811122 |
29 | TYK2 | 1.53637570 |
30 | PIK3CG | 1.53580891 |
31 | EPHA2 | 1.53246328 |
32 | TBK1 | 1.52666733 |
33 | MAP3K3 | 1.52113799 |
34 | NEK9 | 1.50760356 |
35 | KDR | 1.46178389 |
36 | AKT3 | 1.43993284 |
37 | IRAK3 | 1.39370946 |
38 | DYRK2 | 1.39074421 |
39 | TIE1 | 1.36787894 |
40 | FER | 1.35297927 |
41 | FRK | 1.33290014 |
42 | NME2 | 1.32460850 |
43 | TLK1 | 1.30186383 |
44 | FGFR2 | 1.27658521 |
45 | IKBKE | 1.16963016 |
46 | STK24 | 1.15734997 |
47 | VRK1 | 1.15353816 |
48 | EIF2AK1 | 1.09011374 |
49 | MAPK11 | 1.04838397 |
50 | CASK | 1.04041729 |
51 | MAPK15 | 1.01115814 |
52 | BLK | 0.98736858 |
53 | PRKCG | 0.97864616 |
54 | PRKCI | 0.96783808 |
55 | PINK1 | 0.95688947 |
56 | FLT3 | 0.95424716 |
57 | MAP3K11 | 0.92787364 |
58 | JAK2 | 0.92512517 |
59 | MAP2K4 | 0.89856150 |
60 | STK38L | 0.89714868 |
61 | TAF1 | 0.87994450 |
62 | IRAK2 | 0.87519698 |
63 | TGFBR2 | 0.87153645 |
64 | PRKCE | 0.84968752 |
65 | TTK | 0.84643498 |
66 | STK16 | 0.83814355 |
67 | GRK1 | 0.83135143 |
68 | MAPK4 | 0.83027995 |
69 | MYLK | 0.82981412 |
70 | MKNK2 | 0.82031810 |
71 | NEK1 | 0.81481183 |
72 | BCR | 0.80422242 |
73 | CSNK1G1 | 0.79693355 |
74 | MAP2K3 | 0.79093526 |
75 | PRKCQ | 0.79025934 |
76 | GSK3A | 0.77825850 |
77 | CSK | 0.76524319 |
78 | JAK1 | 0.76417537 |
79 | IRAK1 | 0.75545423 |
80 | PRKAA2 | 0.74582088 |
81 | ADRBK1 | 0.72442292 |
82 | IKBKB | 0.71885634 |
83 | CAMK2G | 0.71839989 |
84 | DAPK2 | 0.69689761 |
85 | PKN1 | 0.69320194 |
86 | LATS1 | 0.68761511 |
87 | WNK3 | 0.68455125 |
88 | MAP2K2 | 0.68015150 |
89 | CSNK1G3 | 0.67949420 |
90 | GRK6 | 0.67337518 |
91 | NUAK1 | 0.66656623 |
92 | PLK3 | 0.66427516 |
93 | IRAK4 | 0.63676450 |
94 | PRKACA | 0.62000549 |
95 | SGK223 | 0.61695847 |
96 | SGK494 | 0.61695847 |
97 | PRKCZ | 0.59325355 |
98 | CSNK1A1L | 0.59140060 |
99 | ERBB2 | 0.58327483 |
100 | CSNK1A1 | 0.55176787 |
101 | CSNK1E | 0.53615134 |
102 | PRKCA | 0.52914277 |
103 | PDPK1 | 0.52672943 |
104 | PRKACG | 0.52258014 |
105 | PTK6 | 0.51807818 |
106 | TRIM28 | 0.51197676 |
107 | EPHB2 | 0.51191839 |
108 | CSNK2A1 | 0.51015630 |
109 | ILK | 0.50959223 |
110 | PIK3CA | 0.50933639 |
111 | ADRBK2 | 0.50516211 |
112 | EPHA3 | 0.50114962 |
113 | DYRK1B | 0.49582036 |
114 | CSNK2A2 | 0.49421685 |
115 | TGFBR1 | 0.47638299 |
116 | BMPR2 | 0.46255102 |
117 | PLK1 | 0.46158008 |
118 | TSSK6 | 0.46078171 |
119 | DAPK3 | 0.45758496 |
120 | BUB1 | 0.45625712 |
121 | STK3 | 0.45388644 |
122 | CDK6 | 0.44827314 |
123 | MUSK | 0.43757805 |
124 | MAPK12 | 0.43393175 |
125 | IGF1R | 0.42927798 |
126 | ABL1 | 0.42714362 |
127 | CSNK1G2 | 0.42482438 |
128 | MAPKAPK5 | 0.42472683 |
129 | PRKG2 | 0.42244705 |
130 | MAP2K1 | 0.42059849 |
131 | PKN2 | 0.40734249 |
132 | MAPK7 | 0.39939980 |
133 | PRKG1 | 0.39740109 |
134 | MAP2K6 | 0.39730310 |
135 | MAP3K2 | 0.39578271 |
136 | GRK5 | 0.38888019 |
137 | LRRK2 | 0.37619277 |
138 | NLK | 0.36299386 |
139 | STK4 | 0.35684339 |
140 | PDK2 | 0.35411207 |
141 | CSF1R | 0.35236955 |
142 | PRKCD | 0.32747509 |
143 | KIT | 0.32290903 |
144 | RPS6KA5 | 0.31768457 |
145 | PRKAA1 | 0.31675560 |
146 | LYN | 0.31372597 |
147 | EIF2AK2 | 0.29599738 |
148 | PAK3 | 0.29131352 |
149 | ZAP70 | 0.28008081 |
150 | PRKACB | 0.27792654 |
151 | PIM2 | 0.27735911 |
152 | GRK7 | 0.27107364 |
153 | CHUK | 0.25144008 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 3.99210429 |
2 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 3.40488428 |
3 | Nitrogen metabolism_Homo sapiens_hsa00910 | 2.73715020 |
4 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 2.66424523 |
5 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 2.63515414 |
6 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 2.60265716 |
7 | Tryptophan metabolism_Homo sapiens_hsa00380 | 2.54712947 |
8 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 2.51495413 |
9 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 2.51243353 |
10 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 2.47199466 |
11 | Arginine biosynthesis_Homo sapiens_hsa00220 | 2.45337346 |
12 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 2.44269050 |
13 | Fatty acid degradation_Homo sapiens_hsa00071 | 2.43585734 |
14 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 2.40557012 |
15 | Butanoate metabolism_Homo sapiens_hsa00650 | 2.30914816 |
16 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 2.26416274 |
17 | Peroxisome_Homo sapiens_hsa04146 | 2.26220804 |
18 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 2.20460335 |
19 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 2.15176489 |
20 | Propanoate metabolism_Homo sapiens_hsa00640 | 2.10584317 |
21 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 2.07525384 |
22 | Histidine metabolism_Homo sapiens_hsa00340 | 2.03723803 |
23 | Retinol metabolism_Homo sapiens_hsa00830 | 1.83021099 |
24 | Fatty acid metabolism_Homo sapiens_hsa01212 | 1.82821818 |
25 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.82183077 |
26 | PPAR signaling pathway_Homo sapiens_hsa03320 | 1.81970346 |
27 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 1.78525779 |
28 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.78197437 |
29 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.75510558 |
30 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.74637953 |
31 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 1.72059914 |
32 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 1.64454279 |
33 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 1.57095732 |
34 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 1.55421763 |
35 | Tyrosine metabolism_Homo sapiens_hsa00350 | 1.48252095 |
36 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.47194477 |
37 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.41417151 |
38 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.31404938 |
39 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.31153117 |
40 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.28942437 |
41 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 1.28840747 |
42 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 1.28522575 |
43 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 1.27134991 |
44 | Bile secretion_Homo sapiens_hsa04976 | 1.23064605 |
45 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.21524729 |
46 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.17688170 |
47 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.14927301 |
48 | Fat digestion and absorption_Homo sapiens_hsa04975 | 1.08545729 |
49 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 1.06867520 |
50 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 1.04924470 |
51 | ABC transporters_Homo sapiens_hsa02010 | 1.04588218 |
52 | Carbon metabolism_Homo sapiens_hsa01200 | 1.04122577 |
53 | Sulfur relay system_Homo sapiens_hsa04122 | 1.03918462 |
54 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 1.00036295 |
55 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.92766270 |
56 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.88262368 |
57 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.87681876 |
58 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.80698148 |
59 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.74129463 |
60 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.71551255 |
61 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.70023815 |
62 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.65940012 |
63 | Ribosome_Homo sapiens_hsa03010 | 0.63547620 |
64 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.60595343 |
65 | Metabolic pathways_Homo sapiens_hsa01100 | 0.58635899 |
66 | Huntingtons disease_Homo sapiens_hsa05016 | 0.56888455 |
67 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.51869805 |
68 | Lysine degradation_Homo sapiens_hsa00310 | 0.48675059 |
69 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.46388713 |
70 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.45840781 |
71 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.41935982 |
72 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.40995265 |
73 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.40961520 |
74 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.40771895 |
75 | RNA polymerase_Homo sapiens_hsa03020 | 0.37989414 |
76 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.26159325 |
77 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.24840239 |
78 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.22794804 |
79 | Protein digestion and absorption_Homo sapiens_hsa04974 | 0.21466610 |
80 | Prion diseases_Homo sapiens_hsa05020 | 0.20706309 |
81 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.20510380 |
82 | Galactose metabolism_Homo sapiens_hsa00052 | 0.19117329 |
83 | Parkinsons disease_Homo sapiens_hsa05012 | 0.15440880 |
84 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.15191783 |
85 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.14505341 |
86 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.13791926 |
87 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.11258655 |
88 | Protein export_Homo sapiens_hsa03060 | 0.09601765 |
89 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.08976407 |
90 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.06629180 |
91 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.05907437 |
92 | Alzheimers disease_Homo sapiens_hsa05010 | 0.05884550 |
93 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.04068398 |
94 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.03502044 |
95 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.03349683 |
96 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.03296496 |
97 | Insulin resistance_Homo sapiens_hsa04931 | 0.02598145 |
98 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 0.01230271 |
99 | Regulation of autophagy_Homo sapiens_hsa04140 | -0.1089356 |
100 | Rheumatoid arthritis_Homo sapiens_hsa05323 | -0.1079723 |
101 | Proteasome_Homo sapiens_hsa03050 | -0.1032233 |
102 | Hepatitis C_Homo sapiens_hsa05160 | -0.0882727 |
103 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | -0.0859916 |
104 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | -0.0828139 |
105 | Other glycan degradation_Homo sapiens_hsa00511 | -0.0814399 |
106 | Renin-angiotensin system_Homo sapiens_hsa04614 | -0.0800328 |
107 | African trypanosomiasis_Homo sapiens_hsa05143 | -0.0733703 |
108 | Pertussis_Homo sapiens_hsa05133 | -0.0697127 |
109 | Malaria_Homo sapiens_hsa05144 | -0.0630239 |
110 | Collecting duct acid secretion_Homo sapiens_hsa04966 | -0.0615208 |
111 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | -0.0303071 |
112 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | -0.0279018 |
113 | Lysosome_Homo sapiens_hsa04142 | -0.0230107 |
114 | Mineral absorption_Homo sapiens_hsa04978 | -0.0057770 |