CYB5A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a membrane-bound cytochrome that reduces ferric hemoglobin (methemoglobin) to ferrous hemoglobin, which is required for stearyl-CoA-desaturase activity. Defects in this gene are a cause of type IV hereditary methemoglobinemia. Three transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.16766354
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.16766354
3L-phenylalanine metabolic process (GO:0006558)6.82685588
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.82685588
5aromatic amino acid family catabolic process (GO:0009074)6.32549357
6glyoxylate metabolic process (GO:0046487)5.68215541
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.58449459
8tryptophan catabolic process (GO:0006569)5.57754377
9indole-containing compound catabolic process (GO:0042436)5.57754377
10indolalkylamine catabolic process (GO:0046218)5.57754377
11omega-hydroxylase P450 pathway (GO:0097267)5.57740426
12bile acid biosynthetic process (GO:0006699)5.49818506
13cysteine metabolic process (GO:0006534)5.37719792
14tryptophan metabolic process (GO:0006568)5.27531545
15kynurenine metabolic process (GO:0070189)5.23250901
16sulfur amino acid catabolic process (GO:0000098)5.08031130
17alpha-linolenic acid metabolic process (GO:0036109)4.99395332
18ethanol metabolic process (GO:0006067)4.93022459
19high-density lipoprotein particle remodeling (GO:0034375)4.85122195
20peptidyl-glutamic acid carboxylation (GO:0017187)4.78313224
21protein carboxylation (GO:0018214)4.78313224
22fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.76993364
23urea metabolic process (GO:0019627)4.75628967
24urea cycle (GO:0000050)4.75628967
25aldehyde catabolic process (GO:0046185)4.72444565
26negative regulation of fibrinolysis (GO:0051918)4.67118219
27complement activation, alternative pathway (GO:0006957)4.66629501
28aromatic amino acid family metabolic process (GO:0009072)4.64375283
29oxidative demethylation (GO:0070989)4.63841891
30bile acid metabolic process (GO:0008206)4.62607661
31tyrosine metabolic process (GO:0006570)4.58263339
32regulation of fibrinolysis (GO:0051917)4.58023273
33cellular glucuronidation (GO:0052695)4.56196648
34phenylpropanoid metabolic process (GO:0009698)4.55663425
35primary alcohol catabolic process (GO:0034310)4.53297927
36regulation of protein activation cascade (GO:2000257)4.51805056
37serine family amino acid catabolic process (GO:0009071)4.49127147
38nitrogen cycle metabolic process (GO:0071941)4.44249122
39regulation of cholesterol esterification (GO:0010872)4.43034524
40uronic acid metabolic process (GO:0006063)4.41911287
41glucuronate metabolic process (GO:0019585)4.41911287
42homocysteine metabolic process (GO:0050667)4.39705606
43regulation of triglyceride catabolic process (GO:0010896)4.38532035
44amino-acid betaine metabolic process (GO:0006577)4.32754415
45lysine catabolic process (GO:0006554)4.25528970
46lysine metabolic process (GO:0006553)4.25528970
47regulation of complement activation (GO:0030449)4.24629596
48reverse cholesterol transport (GO:0043691)4.23510570
49cellular ketone body metabolic process (GO:0046950)4.22275975
50plasma lipoprotein particle clearance (GO:0034381)4.22119523
51blood coagulation, intrinsic pathway (GO:0007597)4.21499666
52ethanol oxidation (GO:0006069)4.20724556
53alpha-amino acid catabolic process (GO:1901606)4.19285617
54plasma lipoprotein particle remodeling (GO:0034369)4.18372615
55protein-lipid complex remodeling (GO:0034368)4.18372615
56macromolecular complex remodeling (GO:0034367)4.18372615
57benzene-containing compound metabolic process (GO:0042537)4.13314152
58triglyceride homeostasis (GO:0070328)4.09128572
59acylglycerol homeostasis (GO:0055090)4.09128572
60drug catabolic process (GO:0042737)4.08652868
61cellular biogenic amine catabolic process (GO:0042402)4.04100974
62amine catabolic process (GO:0009310)4.04100974
63phospholipid efflux (GO:0033700)4.03427420
64response to nitrosative stress (GO:0051409)4.03349459
65polyketide metabolic process (GO:0030638)4.02536965
66doxorubicin metabolic process (GO:0044598)4.02536965
67daunorubicin metabolic process (GO:0044597)4.02536965
68indolalkylamine metabolic process (GO:0006586)4.00609719
69intestinal cholesterol absorption (GO:0030299)3.98248685
70coenzyme catabolic process (GO:0009109)3.96114504
71cellular amino acid catabolic process (GO:0009063)3.93588774
72serine family amino acid metabolic process (GO:0009069)3.91562730
73short-chain fatty acid metabolic process (GO:0046459)3.90371678
74negative regulation of cholesterol transport (GO:0032375)3.89570699
75negative regulation of sterol transport (GO:0032372)3.89570699
76drug transmembrane transport (GO:0006855)3.84127739
77S-adenosylmethionine metabolic process (GO:0046500)3.82443357
78cofactor catabolic process (GO:0051187)3.81484660
79cholesterol efflux (GO:0033344)3.79807137
80primary alcohol metabolic process (GO:0034308)3.79649555
81negative regulation of protein activation cascade (GO:2000258)3.79301836
82acetyl-CoA metabolic process (GO:0006084)3.77375671
83fibrinolysis (GO:0042730)3.75603770
84bile acid and bile salt transport (GO:0015721)3.75226718
85xenobiotic catabolic process (GO:0042178)3.74481955
86ketone body metabolic process (GO:1902224)3.73691407
87urate metabolic process (GO:0046415)3.73480076
88heme transport (GO:0015886)3.72343202
89serine family amino acid biosynthetic process (GO:0009070)3.71922425
90glutamate metabolic process (GO:0006536)3.69283583
91exogenous drug catabolic process (GO:0042738)3.66670162
92cellular modified amino acid catabolic process (GO:0042219)3.66487263
93aminoglycoside antibiotic metabolic process (GO:0030647)3.66159942
94flavonoid metabolic process (GO:0009812)3.62760032
95carboxylic acid catabolic process (GO:0046395)3.62728951
96organic acid catabolic process (GO:0016054)3.62728951
97glycine metabolic process (GO:0006544)3.61996026
98positive regulation of lipoprotein lipase activity (GO:0051006)3.61971810
99positive regulation of triglyceride lipase activity (GO:0061365)3.61971810
100negative regulation of lipase activity (GO:0060192)3.60629138
101protein activation cascade (GO:0072376)3.60119494
102arginine metabolic process (GO:0006525)3.56738701
103regulation of plasminogen activation (GO:0010755)3.56675512
104xenobiotic metabolic process (GO:0006805)3.56278370
105imidazole-containing compound metabolic process (GO:0052803)3.54638013
106very-low-density lipoprotein particle assembly (GO:0034379)3.54327276
107drug metabolic process (GO:0017144)3.54068925
108fatty acid beta-oxidation (GO:0006635)3.53981382
109low-density lipoprotein particle remodeling (GO:0034374)3.53910017
110fatty acid oxidation (GO:0019395)3.53293907
111monocarboxylic acid catabolic process (GO:0072329)3.52995118
112plasma lipoprotein particle assembly (GO:0034377)3.51003395
113cholesterol homeostasis (GO:0042632)3.48754521
114very long-chain fatty acid metabolic process (GO:0000038)3.47653948
115negative regulation of hemostasis (GO:1900047)3.47648254
116negative regulation of blood coagulation (GO:0030195)3.47648254
117lipid oxidation (GO:0034440)3.47307531
118epoxygenase P450 pathway (GO:0019373)3.46411193
119opsonization (GO:0008228)3.45463452
120sterol homeostasis (GO:0055092)3.43621835
121alkaloid metabolic process (GO:0009820)3.42603223
122complement activation (GO:0006956)3.41023548
123complement activation, classical pathway (GO:0006958)3.40868923
124water-soluble vitamin biosynthetic process (GO:0042364)3.36587273
125acute-phase response (GO:0006953)3.35235328
126negative regulation of complement activation (GO:0045916)3.32876552
127vitamin biosynthetic process (GO:0009110)3.29062933
128negative regulation of coagulation (GO:0050819)3.26596762
129fat-soluble vitamin biosynthetic process (GO:0042362)3.21538592
130hormone catabolic process (GO:0042447)3.19895298
131regulation of humoral immune response (GO:0002920)3.19119761
132negative regulation of wound healing (GO:0061045)3.08359911
133intestinal absorption (GO:0050892)3.07784027

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.52250473
2EGR1_23403033_ChIP-Seq_LIVER_Mouse6.58688538
3PPARA_22158963_ChIP-Seq_LIVER_Mouse6.39305447
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.88792059
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.23517113
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.80423404
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.79167567
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.76704330
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.34994490
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.24339559
11HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.14790371
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.12028908
13ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.6485317
14TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.97793891
15VDR_22108803_ChIP-Seq_LS180_Human1.89181169
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.83548769
17STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.83149534
18TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.76066748
19CLOCK_20551151_ChIP-Seq_293T_Human1.64522191
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.58836713
21IRF8_22096565_ChIP-ChIP_GC-B_Human1.50928348
22GABP_17652178_ChIP-ChIP_JURKAT_Human1.49952827
23HTT_18923047_ChIP-ChIP_STHdh_Human1.46127102
24PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.40322272
25BCAT_22108803_ChIP-Seq_LS180_Human1.37074776
26FOXA1_27270436_Chip-Seq_PROSTATE_Human1.33203494
27FOXA1_25329375_ChIP-Seq_VCAP_Human1.33203494
28NFE2_27457419_Chip-Seq_LIVER_Mouse1.30003413
29FOXA2_19822575_ChIP-Seq_HepG2_Human1.28697417
30GATA1_22025678_ChIP-Seq_K562_Human1.26182510
31Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.24778993
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24616564
33SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.20420926
34* HNF4A_19822575_ChIP-Seq_HepG2_Human1.19050983
35ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.18876590
36FLI1_27457419_Chip-Seq_LIVER_Mouse1.17321416
37RARG_19884340_ChIP-ChIP_MEFs_Mouse1.16721536
38SOX2_19829295_ChIP-Seq_ESCs_Human1.16624630
39NANOG_19829295_ChIP-Seq_ESCs_Human1.16624630
40TCF4_22108803_ChIP-Seq_LS180_Human1.15375646
41IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.15372042
42NRF2_20460467_ChIP-Seq_MEFs_Mouse1.14344634
43NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.14344634
44* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14135688
45SOX2_27498859_Chip-Seq_STOMACH_Mouse1.13965401
46FOXA1_21572438_ChIP-Seq_LNCaP_Human1.13117733
47EZH2_27294783_Chip-Seq_NPCs_Mouse1.12255758
48GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.11143728
49THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.10965115
50ZNF274_21170338_ChIP-Seq_K562_Hela1.10936397
51SUZ12_27294783_Chip-Seq_NPCs_Mouse1.10823906
52BP1_19119308_ChIP-ChIP_Hs578T_Human1.10504968
53PHF8_20622853_ChIP-Seq_HELA_Human1.10061913
54HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.09367990
55ER_23166858_ChIP-Seq_MCF-7_Human1.08057750
56EST1_17652178_ChIP-ChIP_JURKAT_Human1.08014068
57CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.07853698
58POU3F2_20337985_ChIP-ChIP_501MEL_Human1.07435124
59PCGF2_27294783_Chip-Seq_ESCs_Mouse1.07023050
60GATA4_25053715_ChIP-Seq_YYC3_Human1.06887348
61* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.05756414
62E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.05243943
63HNFA_21074721_ChIP-Seq_CACO-2_Human1.03303016
64PCGF2_27294783_Chip-Seq_NPCs_Mouse1.02464156
65ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01414479
66GATA3_21878914_ChIP-Seq_MCF-7_Human1.00982360
67FOXM1_26456572_ChIP-Seq_MCF-7_Human1.00518787
68NCOR_22424771_ChIP-Seq_293T_Human0.99292096
69GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.97440381
70RXRA_24833708_ChIP-Seq_LIVER_Mouse0.97360488
71ETV1_20927104_ChIP-Seq_GIST48_Human0.96769520
72CRX_20693478_ChIP-Seq_RETINA_Mouse0.95998700
73P300_19829295_ChIP-Seq_ESCs_Human0.95348050
74PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.94033708
75RBPJ_21746931_ChIP-Seq_IB4_Human0.93889130
76GATA6_21074721_ChIP-Seq_CACO-2_Human0.93431314
77KLF5_20875108_ChIP-Seq_MESCs_Mouse0.93216870
78IGF1R_20145208_ChIP-Seq_DFB_Human0.92337036
79SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.92280741
80GATA6_25053715_ChIP-Seq_YYC3_Human0.91484875
81CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.89961981
82P53_21459846_ChIP-Seq_SAOS-2_Human0.88505965
83EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.88053484
84NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.86670496
85NFYA_21822215_ChIP-Seq_K562_Human0.85780740
86SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.85658691
87SALL4_18804426_ChIP-ChIP_XEN_Mouse0.85505627
88TRIM28_21343339_ChIP-Seq_HEK293_Human0.85016641
89KAP1_22055183_ChIP-Seq_ESCs_Mouse0.84508368
90CBP_20019798_ChIP-Seq_JUKART_Human0.83575917
91IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.83575917
92STAT3_18555785_Chip-Seq_ESCs_Mouse0.82973517
93* SOX2_20726797_ChIP-Seq_SW620_Human0.82454797
94ETV2_25802403_ChIP-Seq_MESCs_Mouse0.82336033
95NANOG_20526341_ChIP-Seq_ESCs_Human0.82312099
96AUTS2_25519132_ChIP-Seq_293T-REX_Human0.79649049
97NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.77544069
98ESR1_21235772_ChIP-Seq_MCF-7_Human0.77404926
99BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.75845228
100PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.73236737
101SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.72996713
102FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.72029223
103RAD21_21589869_ChIP-Seq_MESCs_Mouse0.71678877
104BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.70715692
105EGR1_19032775_ChIP-ChIP_M12_Human0.70307429
106FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.70057648
107PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.69821742
108* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.68610202
109STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.68512009
110AR_20517297_ChIP-Seq_VCAP_Human0.68274655
111CDX2_20551321_ChIP-Seq_CACO-2_Human0.67862281
112* ESR2_21235772_ChIP-Seq_MCF-7_Human0.67513240
113CEBPB_22108803_ChIP-Seq_LS180_Human0.65479226
114IRF8_21731497_ChIP-ChIP_J774_Mouse0.64706017
115PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.64125543
116TAF15_26573619_Chip-Seq_HEK293_Human0.63239017
117PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.62376950
118FOXA1_25552417_ChIP-Seq_VCAP_Human0.61267980
119PPAR_26484153_Chip-Seq_NCI-H1993_Human0.60385134
120ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.60287858
121MYC_19915707_ChIP-ChIP_AK7_Human0.58831948
122FOXO3_23340844_ChIP-Seq_DLD1_Human0.58567555
123CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.57210924
124STAT1_17558387_ChIP-Seq_HELA_Human0.55673507
125CBP_21632823_ChIP-Seq_H3396_Human0.52624789
126PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.52327678
127EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.51088101
128ESET_19884257_ChIP-Seq_ESCs_Mouse0.50712390
129PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.50658583
130IRF8_27001747_Chip-Seq_BMDM_Mouse0.50325050
131P63_26484246_Chip-Seq_KERATINOCYTES_Human0.50302456
132SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.49600752
133CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.48156172
134NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.47840120
135IRF1_19129219_ChIP-ChIP_H3396_Human0.47682260
136FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.47643541
137RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.47429924
138RARB_24833708_ChIP-Seq_LIVER_Mouse0.46826889
139RARA_24833708_ChIP-Seq_LIVER_Mouse0.46668820
140TP63_17297297_ChIP-ChIP_HaCaT_Human0.46529810
141ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.46287834
142SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.45955410
143TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.45262685
144CSB_26484114_Chip-Seq_FIBROBLAST_Human0.45152232
145GATA3_24758297_ChIP-Seq_MCF-7_Human0.44073886
146CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.44033157
147PIAS1_25552417_ChIP-Seq_VCAP_Human0.43913047
148FOXH1_21741376_ChIP-Seq_EPCs_Human0.43625011
149IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.43568423
150GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.43346041
151ESR1_20079471_ChIP-ChIP_T-47D_Human0.42819142
152CDX2_22108803_ChIP-Seq_LS180_Human0.42523752
153ERG_20517297_ChIP-Seq_VCAP_Human0.42293364
154SRF_21415370_ChIP-Seq_HL-1_Mouse0.41993086

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.61401972
2MP0005360_urolithiasis7.15054469
3MP0005085_abnormal_gallbladder_physiolo5.73925361
4MP0005365_abnormal_bile_salt5.47734808
5MP0008875_abnormal_xenobiotic_pharmacok5.33865888
6MP0003806_abnormal_nucleotide_metabolis4.40850991
7MP0003252_abnormal_bile_duct3.44833952
8MP0010329_abnormal_lipoprotein_level3.23270138
9MP0003195_calcinosis3.03252140
10MP0005332_abnormal_amino_acid2.89039500
11MP0009840_abnormal_foam_cell2.84705275
12MP0005083_abnormal_biliary_tract2.83545695
13MP0004019_abnormal_vitamin_homeostasis2.43163142
14MP0001666_abnormal_nutrient_absorption2.41724410
15MP0003191_abnormal_cellular_cholesterol2.26763078
16MP0002138_abnormal_hepatobiliary_system2.12513316
17MP0003186_abnormal_redox_activity2.09513949
18MP0002118_abnormal_lipid_homeostasis2.00605597
19MP0000609_abnormal_liver_physiology1.92158974
20MP0005451_abnormal_body_composition1.75504496
21MP0005319_abnormal_enzyme/_coenzyme1.73241385
22MP0005584_abnormal_enzyme/coenzyme_acti1.63846409
23MP0001764_abnormal_homeostasis1.62570924
24MP0009643_abnormal_urine_homeostasis1.54489993
25MP0003011_delayed_dark_adaptation1.54186447
26MP0005408_hypopigmentation1.46569037
27MP0009697_abnormal_copulation1.46159083
28MP0003941_abnormal_skin_development1.45427864
29MP0003868_abnormal_feces_composition1.36506779
30MP0009764_decreased_sensitivity_to1.28977993
31MP0003656_abnormal_erythrocyte_physiolo1.26894453
32MP0005636_abnormal_mineral_homeostasis1.23312090
33MP0010386_abnormal_urinary_bladder1.12943149
34MP0003724_increased_susceptibility_to1.10183602
35MP0000604_amyloidosis1.08966918
36MP0002254_reproductive_system_inflammat1.08109537
37MP0005647_abnormal_sex_gland1.07253526
38MP0003690_abnormal_glial_cell1.06890046
39MP0009763_increased_sensitivity_to1.03670305
40MP0000598_abnormal_liver_morphology1.03537325
41MP0008469_abnormal_protein_level1.01397012
42MP0002876_abnormal_thyroid_physiology1.01020310
43MP0005084_abnormal_gallbladder_morpholo0.96861967
44MP0006036_abnormal_mitochondrial_physio0.93802485
45MP0009765_abnormal_xenobiotic_induced0.90001956
46MP0002909_abnormal_adrenal_gland0.88529866
47MP0005670_abnormal_white_adipose0.83933118
48MP0005376_homeostasis/metabolism_phenot0.83513066
49MP0009642_abnormal_blood_homeostasis0.83505736
50MP0001756_abnormal_urination0.83351460
51MP0010368_abnormal_lymphatic_system0.81698043
52MP0004043_abnormal_pH_regulation0.81381749
53MP0005058_abnormal_lysosome_morphology0.80268925
54MP0001661_extended_life_span0.80124290
55MP0004381_abnormal_hair_follicle0.78777287
56MP0002136_abnormal_kidney_physiology0.76341969
57MP0005535_abnormal_body_temperature0.74555395
58MP0006082_CNS_inflammation0.74051027
59MP0005551_abnormal_eye_electrophysiolog0.74039553
60MP0004782_abnormal_surfactant_physiolog0.73237336
61MP0002638_abnormal_pupillary_reflex0.73183067
62MP0002282_abnormal_trachea_morphology0.69290750
63MP0002132_abnormal_respiratory_system0.66777693
64MP0003953_abnormal_hormone_level0.66579885
65MP0002971_abnormal_brown_adipose0.66386200
66MP0003436_decreased_susceptibility_to0.66316655
67MP0005334_abnormal_fat_pad0.65677416
68MP0009780_abnormal_chondrocyte_physiolo0.65342585
69MP0001485_abnormal_pinna_reflex0.64435888
70MP0004147_increased_porphyrin_level0.62022712
71MP0002078_abnormal_glucose_homeostasis0.60221343
72MP0003329_amyloid_beta_deposits0.59908879
73MP0002938_white_spotting0.59626251
74MP0003705_abnormal_hypodermis_morpholog0.59422901
75MP0005266_abnormal_metabolism0.59420914
76MP0002796_impaired_skin_barrier0.58988506
77MP0004130_abnormal_muscle_cell0.57612442
78MP0003718_maternal_effect0.56908838
79MP0002277_abnormal_respiratory_mucosa0.56766644
80MP0005164_abnormal_response_to0.55662680
81MP0005395_other_phenotype0.55578716
82MP0002295_abnormal_pulmonary_circulatio0.55275351
83MP0005220_abnormal_exocrine_pancreas0.55254295
84MP0003638_abnormal_response/metabolism_0.55153969
85MP0001984_abnormal_olfaction0.54944269
86MP0003075_altered_response_to0.54192644
87MP0000538_abnormal_urinary_bladder0.54081442
88MP0005464_abnormal_platelet_physiology0.53604437
89MP0009379_abnormal_foot_pigmentation0.53344197
90MP0003879_abnormal_hair_cell0.53230487
91MP0009785_altered_susceptibility_to0.52501216
92MP0000920_abnormal_myelination0.52036638
93MP0005645_abnormal_hypothalamus_physiol0.51577382
94MP0005379_endocrine/exocrine_gland_phen0.49806819
95MP0008873_increased_physiological_sensi0.49304003
96MP0001944_abnormal_pancreas_morphology0.48797389
97MP0004133_heterotaxia0.48682021
98MP0005166_decreased_susceptibility_to0.47838078
99MP0002090_abnormal_vision0.47815426
100MP0001853_heart_inflammation0.47017405
101MP0005666_abnormal_adipose_tissue0.46922860
102MP0009115_abnormal_fat_cell0.46530868
103MP0009053_abnormal_anal_canal0.46440589
104MP0006035_abnormal_mitochondrial_morpho0.46379299
105MP0001845_abnormal_inflammatory_respons0.44669999
106MP0003950_abnormal_plasma_membrane0.43239207
107MP0005410_abnormal_fertilization0.42206003
108MP0000230_abnormal_systemic_arterial0.41462260
109MP0005187_abnormal_penis_morphology0.41241585
110MP0000639_abnormal_adrenal_gland0.41027022
111MP0002970_abnormal_white_adipose0.40645361
112MP0004883_abnormal_blood_vessel0.40546002
113MP0002419_abnormal_innate_immunity0.40519394
114MP0008874_decreased_physiological_sensi0.40353528
115MP0000566_synostosis0.40333715
116MP0005448_abnormal_energy_balance0.39850873
117MP0001765_abnormal_ion_homeostasis0.39716084
118MP0000249_abnormal_blood_vessel0.39508756
119MP0003453_abnormal_keratinocyte_physiol0.39388898
120MP0008872_abnormal_physiological_respon0.38788237
121MP0005025_abnormal_response_to0.38160147
122MP0003959_abnormal_lean_body0.37252062
123MP0002168_other_aberrant_phenotype0.37122886
124MP0002928_abnormal_bile_duct0.36978620
125MP0001881_abnormal_mammary_gland0.36266758
126MP0005248_abnormal_Harderian_gland0.36212562
127MP0003878_abnormal_ear_physiology0.36052997
128MP0005377_hearing/vestibular/ear_phenot0.36052997
129MP0008995_early_reproductive_senescence0.35708140
130MP0003890_abnormal_embryonic-extraembry0.35694505
131MP0001324_abnormal_eye_pigmentation0.34929349
132MP0005646_abnormal_pituitary_gland0.33488729
133MP0002160_abnormal_reproductive_system0.33056735
134MP0001664_abnormal_digestion0.32913990

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.83207865
2Intrahepatic cholestasis (HP:0001406)6.51600004
3Deep venous thrombosis (HP:0002625)6.26739622
4Xanthomatosis (HP:0000991)5.73080444
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.69893994
6Prolonged partial thromboplastin time (HP:0003645)5.69561725
7Hypobetalipoproteinemia (HP:0003563)5.51479013
8Hyperlipoproteinemia (HP:0010980)5.03127706
9Complement deficiency (HP:0004431)4.56756556
10Hyperammonemia (HP:0001987)4.25984076
11Joint hemorrhage (HP:0005261)4.23729543
12Abnormality of glutamine family amino acid metabolism (HP:0010902)4.23695311
13Abnormality of aspartate family amino acid metabolism (HP:0010899)4.10002415
14Hypolipoproteinemia (HP:0010981)4.08338759
15Hyperglycinuria (HP:0003108)4.07552580
16Hyperglycinemia (HP:0002154)4.06238722
17Epidermoid cyst (HP:0200040)4.01965241
18Abnormality of glycine metabolism (HP:0010895)4.01820503
19Abnormality of serine family amino acid metabolism (HP:0010894)4.01820503
20Ketosis (HP:0001946)3.95229379
21Abnormality of methionine metabolism (HP:0010901)3.91086556
22Fat malabsorption (HP:0002630)3.90865934
23Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.89202112
24Abnormality of sulfur amino acid metabolism (HP:0004339)3.82095228
25Abnormality of the common coagulation pathway (HP:0010990)3.75775626
26Abnormality of fatty-acid metabolism (HP:0004359)3.56750695
27Hypoalphalipoproteinemia (HP:0003233)3.49561846
28Conjugated hyperbilirubinemia (HP:0002908)3.44695503
29Hypercholesterolemia (HP:0003124)3.35606607
30Abnormality of complement system (HP:0005339)3.34429332
31Hypoglycemic coma (HP:0001325)3.33305595
32Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.19040365
33Steatorrhea (HP:0002570)3.14468754
34Abnormality of the intrinsic pathway (HP:0010989)3.14367050
35Abnormality of pyrimidine metabolism (HP:0004353)3.13196193
36Delayed CNS myelination (HP:0002188)3.08283871
37Hyperbilirubinemia (HP:0002904)3.00739961
38Abnormality of nucleobase metabolism (HP:0010932)3.00172356
39Ketoacidosis (HP:0001993)2.95246178
40Abnormality of serum amino acid levels (HP:0003112)2.95234137
41Abnormality of purine metabolism (HP:0004352)2.93660438
42Systemic lupus erythematosus (HP:0002725)2.90178954
43Lethargy (HP:0001254)2.89054381
44Metabolic acidosis (HP:0001942)2.87964392
45Cerebral edema (HP:0002181)2.87170590
46Vascular calcification (HP:0004934)2.78080293
47Hepatocellular carcinoma (HP:0001402)2.76511027
48Nephritis (HP:0000123)2.75718158
49Dicarboxylic aciduria (HP:0003215)2.74938846
50Abnormality of dicarboxylic acid metabolism (HP:0010995)2.74938846
51Gout (HP:0001997)2.66223268
52Generalized aminoaciduria (HP:0002909)2.65237367
53Reduced antithrombin III activity (HP:0001976)2.64027892
54Myocardial infarction (HP:0001658)2.57969277
55Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.54724317
56Glycosuria (HP:0003076)2.51154100
57Abnormality of urine glucose concentration (HP:0011016)2.51154100
58Acute necrotizing encephalopathy (HP:0006965)2.49438519
59Spontaneous abortion (HP:0005268)2.47786973
60Cardiovascular calcification (HP:0011915)2.45022262
61Proximal tubulopathy (HP:0000114)2.41600893
62Vomiting (HP:0002013)2.41174794
63Recurrent gram-negative bacterial infections (HP:0005420)2.38981989
64Abnormal urine phosphate concentration (HP:0012599)2.37891788
65Amyloidosis (HP:0011034)2.37434894
66Alkalosis (HP:0001948)2.35568796
67Abnormal biliary tract physiology (HP:0012439)2.33221667
68Bile duct proliferation (HP:0001408)2.33221667
69Glomerulonephritis (HP:0000099)2.30138613
70Irritability (HP:0000737)2.28824492
71Malnutrition (HP:0004395)2.28371407
72Skin nodule (HP:0200036)2.28302909
73Abnormal respiratory epithelium morphology (HP:0012253)2.27546821
74Abnormal respiratory motile cilium morphology (HP:0005938)2.27546821
75Potter facies (HP:0002009)2.25733251
76Facial shape deformation (HP:0011334)2.25733251
77Dynein arm defect of respiratory motile cilia (HP:0012255)2.25579494
78Absent/shortened dynein arms (HP:0200106)2.25579494
79Rickets (HP:0002748)2.24903065
80Pancreatitis (HP:0001733)2.24534937
81Chronic bronchitis (HP:0004469)2.23447316
82Rhinitis (HP:0012384)2.23383964
83Hydroxyprolinuria (HP:0003080)2.21561652
84Abnormality of proline metabolism (HP:0010907)2.21561652
85Hypochromic microcytic anemia (HP:0004840)2.21481119
86Hypophosphatemic rickets (HP:0004912)2.20373311
87Abnormal mitochondria in muscle tissue (HP:0008316)2.19415205
88Opisthotonus (HP:0002179)2.18120638
89Brushfield spots (HP:0001088)2.17458348
90Abnormal respiratory motile cilium physiology (HP:0012261)2.15890623
91Abnormal gallbladder morphology (HP:0012437)2.15451881
92Enlarged kidneys (HP:0000105)2.15177690
93Spastic diplegia (HP:0001264)2.14275735
94Acanthocytosis (HP:0001927)2.13831670
95Mitochondrial inheritance (HP:0001427)2.13246909
96Osteomalacia (HP:0002749)2.12884909
97Abnormal gallbladder physiology (HP:0012438)2.10052736
98Cholecystitis (HP:0001082)2.10052736
99Hemorrhage of the eye (HP:0011885)2.07719139
100Megaloblastic anemia (HP:0001889)2.07325382
101Esophageal varix (HP:0002040)2.06493341
102Sensorimotor neuropathy (HP:0007141)2.06231586
103Renal cortical cysts (HP:0000803)2.04613143
104Abnormal ciliary motility (HP:0012262)2.04333441
105Cholelithiasis (HP:0001081)2.04085021
106Progressive macrocephaly (HP:0004481)2.03638810
107Abnormality of alanine metabolism (HP:0010916)2.02064018
108Hyperalaninemia (HP:0003348)2.02064018
109Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.02064018
110Increased purine levels (HP:0004368)2.01313211
111Hyperuricemia (HP:0002149)2.01313211
112Nausea (HP:0002018)1.99915919
113Acute encephalopathy (HP:0006846)1.97678297
114Abnormality of glycolysis (HP:0004366)1.96691845
115Increased serum pyruvate (HP:0003542)1.96691845
116Increased CSF lactate (HP:0002490)1.94620476
117Cerebral palsy (HP:0100021)1.94187049
118Mitral stenosis (HP:0001718)1.94096514
119Abnormal enzyme/coenzyme activity (HP:0012379)1.93492921
120Gingival bleeding (HP:0000225)1.92967351
121Neonatal onset (HP:0003623)1.91691753
122Methylmalonic acidemia (HP:0002912)1.91289030
123Abnormal cartilage morphology (HP:0002763)1.90677833
124Abnormality of vitamin B metabolism (HP:0004340)1.90105683
125Menorrhagia (HP:0000132)1.89062504
126Renal Fanconi syndrome (HP:0001994)1.86797643
127Hypoglycemic seizures (HP:0002173)1.86559656
128Hyperactive renin-angiotensin system (HP:0000841)1.85751129
129Abnormality of vitamin metabolism (HP:0100508)1.85379040
130Fair hair (HP:0002286)1.84936117
131Abnormality of the vitamin B12 metabolism (HP:0004341)1.84922992
132Hepatic necrosis (HP:0002605)1.84018592
133Hyperphosphaturia (HP:0003109)1.83014141
134Congenital, generalized hypertrichosis (HP:0004540)1.82088225

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.22931184
2PBK3.79311916
3ACVR1B3.53443648
4FGFR43.11431114
5MST1R3.07967448
6ERN13.02048294
7SIK12.91949888
8MAP3K122.91136199
9STK392.67506330
10OXSR12.43276304
11BMPR1B2.42557375
12ERBB42.40444212
13VRK22.26860526
14WNK42.13243458
15INSRR2.04769904
16NME11.93593329
17ABL21.88344644
18EPHB11.86520358
19MAP3K141.81801937
20ZAK1.81005490
21EIF2AK31.79673720
22MET1.77517619
23TAOK31.77130155
24MAP4K21.72384045
25TNIK1.63370480
26BRSK21.62170869
27MAPKAPK31.60414666
28MST41.58811122
29TYK21.53637570
30PIK3CG1.53580891
31EPHA21.53246328
32TBK11.52666733
33MAP3K31.52113799
34NEK91.50760356
35KDR1.46178389
36AKT31.43993284
37IRAK31.39370946
38DYRK21.39074421
39TIE11.36787894
40FER1.35297927
41FRK1.33290014
42NME21.32460850
43TLK11.30186383
44FGFR21.27658521
45IKBKE1.16963016
46STK241.15734997
47VRK11.15353816
48EIF2AK11.09011374
49MAPK111.04838397
50CASK1.04041729
51MAPK151.01115814
52BLK0.98736858
53PRKCG0.97864616
54PRKCI0.96783808
55PINK10.95688947
56FLT30.95424716
57MAP3K110.92787364
58JAK20.92512517
59MAP2K40.89856150
60STK38L0.89714868
61TAF10.87994450
62IRAK20.87519698
63TGFBR20.87153645
64PRKCE0.84968752
65TTK0.84643498
66STK160.83814355
67GRK10.83135143
68MAPK40.83027995
69MYLK0.82981412
70MKNK20.82031810
71NEK10.81481183
72BCR0.80422242
73CSNK1G10.79693355
74MAP2K30.79093526
75PRKCQ0.79025934
76GSK3A0.77825850
77CSK0.76524319
78JAK10.76417537
79IRAK10.75545423
80PRKAA20.74582088
81ADRBK10.72442292
82IKBKB0.71885634
83CAMK2G0.71839989
84DAPK20.69689761
85PKN10.69320194
86LATS10.68761511
87WNK30.68455125
88MAP2K20.68015150
89CSNK1G30.67949420
90GRK60.67337518
91NUAK10.66656623
92PLK30.66427516
93IRAK40.63676450
94PRKACA0.62000549
95SGK4940.61695847
96SGK2230.61695847
97PRKCZ0.59325355
98CSNK1A1L0.59140060
99ERBB20.58327483
100CSNK1A10.55176787
101CSNK1E0.53615134
102PRKCA0.52914277
103PDPK10.52672943
104PRKACG0.52258014
105PTK60.51807818
106TRIM280.51197676
107EPHB20.51191839
108CSNK2A10.51015630
109ILK0.50959223
110PIK3CA0.50933639
111ADRBK20.50516211
112EPHA30.50114962
113DYRK1B0.49582036
114CSNK2A20.49421685
115TGFBR10.47638299
116BMPR20.46255102
117PLK10.46158008
118TSSK60.46078171
119DAPK30.45758496
120BUB10.45625712
121STK30.45388644
122CDK60.44827314
123MUSK0.43757805
124MAPK120.43393175
125IGF1R0.42927798
126ABL10.42714362
127CSNK1G20.42482438
128MAPKAPK50.42472683
129PRKG20.42244705
130MAP2K10.42059849
131PKN20.40734249
132MAPK70.39939980
133PRKG10.39740109
134MAP2K60.39730310
135MAP3K20.39578271
136GRK50.38888019
137LRRK20.37619277
138NLK0.36299386
139STK40.35684339
140PDK20.35411207
141CSF1R0.35236955
142PRKCD0.32747509
143KIT0.32290903
144RPS6KA50.31768457
145PRKAA10.31675560
146LYN0.31372597
147EIF2AK20.29599738
148PAK30.29131352
149ZAP700.28008081
150PRKACB0.27792654
151PIM20.27735911
152GRK70.27107364
153CHUK0.25144008

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.99210429
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.40488428
3Nitrogen metabolism_Homo sapiens_hsa009102.73715020
4Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.66424523
5Pentose and glucuronate interconversions_Homo sapiens_hsa000402.63515414
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.60265716
7Tryptophan metabolism_Homo sapiens_hsa003802.54712947
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.51495413
9Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.51243353
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.47199466
11Arginine biosynthesis_Homo sapiens_hsa002202.45337346
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.44269050
13Fatty acid degradation_Homo sapiens_hsa000712.43585734
14Complement and coagulation cascades_Homo sapiens_hsa046102.40557012
15Butanoate metabolism_Homo sapiens_hsa006502.30914816
16Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.26416274
17Peroxisome_Homo sapiens_hsa041462.26220804
18Chemical carcinogenesis_Homo sapiens_hsa052042.20460335
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.15176489
20Propanoate metabolism_Homo sapiens_hsa006402.10584317
21Steroid hormone biosynthesis_Homo sapiens_hsa001402.07525384
22Histidine metabolism_Homo sapiens_hsa003402.03723803
23Retinol metabolism_Homo sapiens_hsa008301.83021099
24Fatty acid metabolism_Homo sapiens_hsa012121.82821818
25Caffeine metabolism_Homo sapiens_hsa002321.82183077
26PPAR signaling pathway_Homo sapiens_hsa033201.81970346
27beta-Alanine metabolism_Homo sapiens_hsa004101.78525779
28Sulfur metabolism_Homo sapiens_hsa009201.78197437
29Fatty acid elongation_Homo sapiens_hsa000621.75510558
30Steroid biosynthesis_Homo sapiens_hsa001001.74637953
31Drug metabolism - other enzymes_Homo sapiens_hsa009831.72059914
32Staphylococcus aureus infection_Homo sapiens_hsa051501.64454279
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.57095732
34Phenylalanine metabolism_Homo sapiens_hsa003601.55421763
35Tyrosine metabolism_Homo sapiens_hsa003501.48252095
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.47194477
37Pyruvate metabolism_Homo sapiens_hsa006201.41417151
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.31404938
39Selenocompound metabolism_Homo sapiens_hsa004501.31153117
40Folate biosynthesis_Homo sapiens_hsa007901.28942437
41Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.28840747
42Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.28522575
43Starch and sucrose metabolism_Homo sapiens_hsa005001.27134991
44Bile secretion_Homo sapiens_hsa049761.23064605
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.21524729
46Glutathione metabolism_Homo sapiens_hsa004801.17688170
47Cysteine and methionine metabolism_Homo sapiens_hsa002701.14927301
48Fat digestion and absorption_Homo sapiens_hsa049751.08545729
49Arginine and proline metabolism_Homo sapiens_hsa003301.06867520
50Cyanoamino acid metabolism_Homo sapiens_hsa004601.04924470
51ABC transporters_Homo sapiens_hsa020101.04588218
52Carbon metabolism_Homo sapiens_hsa012001.04122577
53Sulfur relay system_Homo sapiens_hsa041221.03918462
54Vitamin digestion and absorption_Homo sapiens_hsa049771.00036295
55Biosynthesis of amino acids_Homo sapiens_hsa012300.92766270
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.88262368
57Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.87681876
58Vitamin B6 metabolism_Homo sapiens_hsa007500.80698148
59Glycerolipid metabolism_Homo sapiens_hsa005610.74129463
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.71551255
61Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.70023815
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.65940012
63Ribosome_Homo sapiens_hsa030100.63547620
64Pentose phosphate pathway_Homo sapiens_hsa000300.60595343
65Metabolic pathways_Homo sapiens_hsa011000.58635899
66Huntingtons disease_Homo sapiens_hsa050160.56888455
67Fatty acid biosynthesis_Homo sapiens_hsa000610.51869805
68Lysine degradation_Homo sapiens_hsa003100.48675059
69alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.46388713
70Linoleic acid metabolism_Homo sapiens_hsa005910.45840781
71Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.41935982
72Oxidative phosphorylation_Homo sapiens_hsa001900.40995265
73Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.40961520
74One carbon pool by folate_Homo sapiens_hsa006700.40771895
75RNA polymerase_Homo sapiens_hsa030200.37989414
76Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.26159325
77Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.24840239
78Arachidonic acid metabolism_Homo sapiens_hsa005900.22794804
79Protein digestion and absorption_Homo sapiens_hsa049740.21466610
80Prion diseases_Homo sapiens_hsa050200.20706309
81Fructose and mannose metabolism_Homo sapiens_hsa000510.20510380
82Galactose metabolism_Homo sapiens_hsa000520.19117329
83Parkinsons disease_Homo sapiens_hsa050120.15440880
84Sphingolipid metabolism_Homo sapiens_hsa006000.15191783
85Adipocytokine signaling pathway_Homo sapiens_hsa049200.14505341
86Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.13791926
87Ether lipid metabolism_Homo sapiens_hsa005650.11258655
88Protein export_Homo sapiens_hsa030600.09601765
89Glycerophospholipid metabolism_Homo sapiens_hsa005640.08976407
90Cardiac muscle contraction_Homo sapiens_hsa042600.06629180
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.05907437
92Alzheimers disease_Homo sapiens_hsa050100.05884550
93Serotonergic synapse_Homo sapiens_hsa047260.04068398
94Pancreatic secretion_Homo sapiens_hsa049720.03502044
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.03349683
96Pyrimidine metabolism_Homo sapiens_hsa002400.03296496
97Insulin resistance_Homo sapiens_hsa049310.02598145
98Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.01230271
99Regulation of autophagy_Homo sapiens_hsa04140-0.1089356
100Rheumatoid arthritis_Homo sapiens_hsa05323-0.1079723
101Proteasome_Homo sapiens_hsa03050-0.1032233
102Hepatitis C_Homo sapiens_hsa05160-0.0882727
103Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0859916
104Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.0828139
105Other glycan degradation_Homo sapiens_hsa00511-0.0814399
106Renin-angiotensin system_Homo sapiens_hsa04614-0.0800328
107African trypanosomiasis_Homo sapiens_hsa05143-0.0733703
108Pertussis_Homo sapiens_hsa05133-0.0697127
109Malaria_Homo sapiens_hsa05144-0.0630239
110Collecting duct acid secretion_Homo sapiens_hsa04966-0.0615208
111Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0303071
112Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0279018
113Lysosome_Homo sapiens_hsa04142-0.0230107
114Mineral absorption_Homo sapiens_hsa04978-0.0057770

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