CYB5B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.12046957
2L-phenylalanine catabolic process (GO:0006559)6.12046957
3establishment of integrated proviral latency (GO:0075713)5.95264217
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.94831043
5L-phenylalanine metabolic process (GO:0006558)5.94831043
6alpha-linolenic acid metabolic process (GO:0036109)5.79339419
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.40284561
8aromatic amino acid family catabolic process (GO:0009074)5.36379708
9sulfur amino acid catabolic process (GO:0000098)5.20179729
10cysteine metabolic process (GO:0006534)5.14127328
11glyoxylate metabolic process (GO:0046487)4.91233546
12lysine metabolic process (GO:0006553)4.85913785
13lysine catabolic process (GO:0006554)4.85913785
14urea metabolic process (GO:0019627)4.83236687
15urea cycle (GO:0000050)4.83236687
16kynurenine metabolic process (GO:0070189)4.80659334
17bile acid biosynthetic process (GO:0006699)4.75793289
18tryptophan catabolic process (GO:0006569)4.70330165
19indole-containing compound catabolic process (GO:0042436)4.70330165
20indolalkylamine catabolic process (GO:0046218)4.70330165
21homocysteine metabolic process (GO:0050667)4.64540114
22establishment of viral latency (GO:0019043)4.63523561
23fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.62877420
24high-density lipoprotein particle remodeling (GO:0034375)4.58246355
25tryptophan metabolic process (GO:0006568)4.47177757
26DNA strand elongation involved in DNA replication (GO:0006271)4.41935562
27nitrogen cycle metabolic process (GO:0071941)4.40187123
28regulation of triglyceride catabolic process (GO:0010896)4.37455263
29complement activation, alternative pathway (GO:0006957)4.36269360
30peptidyl-glutamic acid carboxylation (GO:0017187)4.30845018
31protein carboxylation (GO:0018214)4.30845018
32negative regulation of fibrinolysis (GO:0051918)4.29378819
33negative regulation of sterol transport (GO:0032372)4.25540029
34negative regulation of cholesterol transport (GO:0032375)4.25540029
35DNA strand elongation (GO:0022616)4.25391249
36ribosome assembly (GO:0042255)4.24338213
37regulation of cholesterol homeostasis (GO:2000188)4.21821592
38serine family amino acid catabolic process (GO:0009071)4.21399099
39bile acid metabolic process (GO:0008206)4.18805615
40intestinal cholesterol absorption (GO:0030299)4.18726394
41reverse cholesterol transport (GO:0043691)4.16391474
42triglyceride homeostasis (GO:0070328)4.11768129
43acylglycerol homeostasis (GO:0055090)4.11768129
44telomere maintenance via semi-conservative replication (GO:0032201)4.10278821
45regulation of protein activation cascade (GO:2000257)4.10131496
46amino-acid betaine metabolic process (GO:0006577)4.09316362
47protein localization to kinetochore (GO:0034501)4.08091266
48protein localization to chromosome, centromeric region (GO:0071459)4.05762609
49DNA unwinding involved in DNA replication (GO:0006268)4.01978245
50mitotic metaphase plate congression (GO:0007080)4.01950414
51cellular modified amino acid catabolic process (GO:0042219)4.01337284
52plasma lipoprotein particle clearance (GO:0034381)4.00322643
53mitotic chromosome condensation (GO:0007076)3.97901426
54drug catabolic process (GO:0042737)3.96002981
55protein-lipid complex remodeling (GO:0034368)3.95105263
56macromolecular complex remodeling (GO:0034367)3.95105263
57plasma lipoprotein particle remodeling (GO:0034369)3.95105263
58nuclear pore complex assembly (GO:0051292)3.91345775
59regulation of fibrinolysis (GO:0051917)3.90305555
60aromatic amino acid family metabolic process (GO:0009072)3.89987714
61cellular ketone body metabolic process (GO:0046950)3.89379258
62mitotic sister chromatid segregation (GO:0000070)3.89031905
63regulation of complement activation (GO:0030449)3.88535729
64alpha-amino acid catabolic process (GO:1901606)3.88415760
65ethanol oxidation (GO:0006069)3.88004383
66valine metabolic process (GO:0006573)3.84277012
67tyrosine metabolic process (GO:0006570)3.82553121
68acetyl-CoA metabolic process (GO:0006084)3.80584690
69cellular glucuronidation (GO:0052695)3.77766823
70nucleobase-containing small molecule interconversion (GO:0015949)3.77208797
71glutamate metabolic process (GO:0006536)3.76919685
72regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.76905461
73drug transmembrane transport (GO:0006855)3.76555748
74regulation of cholesterol esterification (GO:0010872)3.75592985
75phospholipid efflux (GO:0033700)3.75156646
76negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.74419005
77cellular amino acid catabolic process (GO:0009063)3.74100417
78intestinal absorption (GO:0050892)3.73030673
79serine family amino acid metabolic process (GO:0009069)3.70993004
80bile acid and bile salt transport (GO:0015721)3.70230519
812-oxoglutarate metabolic process (GO:0006103)3.69784271
82anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.68585518
83positive regulation of lipid catabolic process (GO:0050996)3.68120874
84DNA ligation (GO:0006266)3.67581518
85glycine metabolic process (GO:0006544)3.67158047
86positive regulation of fatty acid beta-oxidation (GO:0032000)3.65749192
87regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.64040899
88benzene-containing compound metabolic process (GO:0042537)3.62657584
89cholesterol efflux (GO:0033344)3.62335368
90fatty acid beta-oxidation (GO:0006635)3.61171513
91short-chain fatty acid metabolic process (GO:0046459)3.60748791
92low-density lipoprotein particle clearance (GO:0034383)3.60351199
93serine family amino acid biosynthetic process (GO:0009070)3.58512884
94CENP-A containing nucleosome assembly (GO:0034080)3.58136192
95coenzyme catabolic process (GO:0009109)3.56324532
96formation of translation preinitiation complex (GO:0001731)3.55985665
97fatty acid oxidation (GO:0019395)3.55902146
98plasma lipoprotein particle assembly (GO:0034377)3.55028668
99proteasome assembly (GO:0043248)3.54910466
100sister chromatid segregation (GO:0000819)3.54599363
101telomere maintenance via recombination (GO:0000722)3.54154948
102chromatin remodeling at centromere (GO:0031055)3.52526568
103lipoprotein metabolic process (GO:0042157)3.51997149
104dicarboxylic acid biosynthetic process (GO:0043650)3.50762189
105positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.49279334
106epoxygenase P450 pathway (GO:0019373)3.48232537
107phospholipid homeostasis (GO:0055091)3.48189931
108lipid oxidation (GO:0034440)3.48037023
109cholesterol homeostasis (GO:0042632)3.46235930
110sterol homeostasis (GO:0055092)3.45367342
111negative regulation of ligase activity (GO:0051352)3.44550959
112negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.44550959
113non-recombinational repair (GO:0000726)3.43645389
114double-strand break repair via nonhomologous end joining (GO:0006303)3.43645389
115mitotic recombination (GO:0006312)3.43589171
116nuclear pore organization (GO:0006999)3.42886251
117regulation of fatty acid beta-oxidation (GO:0031998)3.42823238
118regulation of mitochondrial translation (GO:0070129)3.40267875
119flavonoid metabolic process (GO:0009812)3.39648438
120ketone body metabolic process (GO:1902224)3.38788518
121aspartate family amino acid catabolic process (GO:0009068)3.38128836
122uronic acid metabolic process (GO:0006063)3.37519344
123glucuronate metabolic process (GO:0019585)3.37519344
124fatty acid catabolic process (GO:0009062)3.36241787
125organic acid catabolic process (GO:0016054)3.35889795
126carboxylic acid catabolic process (GO:0046395)3.35889795
127purine nucleobase biosynthetic process (GO:0009113)3.35882338
128protein-lipid complex assembly (GO:0065005)3.35007750
129monocarboxylic acid catabolic process (GO:0072329)3.34789405
130indolalkylamine metabolic process (GO:0006586)3.34541497
131positive regulation of triglyceride metabolic process (GO:0090208)3.33533169
132IMP biosynthetic process (GO:0006188)3.33475696
133urate metabolic process (GO:0046415)3.33275502
134metaphase plate congression (GO:0051310)3.30410497
135drug metabolic process (GO:0017144)3.27603744
136positive regulation of lipoprotein lipase activity (GO:0051006)3.26540387
137regulation of sister chromatid cohesion (GO:0007063)3.26048566
138folic acid-containing compound biosynthetic process (GO:0009396)3.23557272
139mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.22110927
140regulation of translational fidelity (GO:0006450)3.18552386
141mitotic nuclear envelope disassembly (GO:0007077)3.17205462
142ribosomal large subunit biogenesis (GO:0042273)3.16956159
143nucleobase biosynthetic process (GO:0046112)3.13432205
144spliceosomal snRNP assembly (GO:0000387)3.12145945
145maturation of SSU-rRNA (GO:0030490)3.09973724
146DNA replication initiation (GO:0006270)3.09495199
147positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.05835506
148DNA replication checkpoint (GO:0000076)3.04790728
149DNA topological change (GO:0006265)3.04455718
150spindle checkpoint (GO:0031577)3.01244904
151regulation of cellular amino acid metabolic process (GO:0006521)2.96774739
152regulation of translational termination (GO:0006449)2.94641435
153proline biosynthetic process (GO:0006561)2.94296765
154nuclear envelope disassembly (GO:0051081)2.93905948
155membrane disassembly (GO:0030397)2.93905948
156regulation of chromosome segregation (GO:0051983)2.93729728
157positive regulation of ligase activity (GO:0051351)2.93392975
158maturation of 5.8S rRNA (GO:0000460)2.92423411
159DNA damage response, detection of DNA damage (GO:0042769)2.91152925
160Golgi transport vesicle coating (GO:0048200)2.90606776
161COPI coating of Golgi vesicle (GO:0048205)2.90606776
162mitotic spindle checkpoint (GO:0071174)2.90189880
163signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.89290089
164signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.89290089
165signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.89290089
166signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.88776580
167intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.88776580
168signal transduction involved in DNA damage checkpoint (GO:0072422)2.88628091
169signal transduction involved in DNA integrity checkpoint (GO:0072401)2.88628091
170regulation of ubiquitin-protein transferase activity (GO:0051438)2.88306603
171tRNA aminoacylation for protein translation (GO:0006418)2.88264954
172nucleotide-excision repair, DNA gap filling (GO:0006297)2.87834756
173tRNA aminoacylation (GO:0043039)2.87182047
174amino acid activation (GO:0043038)2.87182047
175pteridine-containing compound biosynthetic process (GO:0042559)2.86664113
176histone exchange (GO:0043486)2.85109598
177cell cycle G1/S phase transition (GO:0044843)2.85019663
178G1/S transition of mitotic cell cycle (GO:0000082)2.85019663
179IMP metabolic process (GO:0046040)2.84821276
180DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.84491720
181establishment of chromosome localization (GO:0051303)2.84172597
182telomere maintenance via telomere lengthening (GO:0010833)2.83846382
183transcription-coupled nucleotide-excision repair (GO:0006283)2.83496756
184ribosome biogenesis (GO:0042254)2.83021489
185regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.82827667
186regulation of mitotic spindle organization (GO:0060236)2.82403786
187signal transduction involved in cell cycle checkpoint (GO:0072395)2.82130452
188ribonucleoprotein complex biogenesis (GO:0022613)2.81708300
189DNA replication-independent nucleosome organization (GO:0034724)2.80902951
190DNA replication-independent nucleosome assembly (GO:0006336)2.80902951
191regulation of spindle organization (GO:0090224)2.80580283
192deoxyribonucleotide biosynthetic process (GO:0009263)2.80420919
193positive regulation of chromosome segregation (GO:0051984)2.79779178
194regulation of ligase activity (GO:0051340)2.78543745
195regulation of cofactor metabolic process (GO:0051193)2.77111799
196regulation of coenzyme metabolic process (GO:0051196)2.77111799
197ribosomal small subunit assembly (GO:0000028)2.76873420
198L-serine metabolic process (GO:0006563)2.76739569
199pore complex assembly (GO:0046931)2.76353409
200negative regulation of chromosome segregation (GO:0051985)2.75318261

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.84775828
2E2F7_22180533_ChIP-Seq_HELA_Human7.14915428
3* RXR_22158963_ChIP-Seq_LIVER_Mouse7.07292302
4PPARA_22158963_ChIP-Seq_LIVER_Mouse6.28465016
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.09053541
6* LXR_22158963_ChIP-Seq_LIVER_Mouse5.65628016
7EGR1_23403033_ChIP-Seq_LIVER_Mouse4.73850244
8MYC_18555785_ChIP-Seq_MESCs_Mouse4.57422143
9FOXM1_23109430_ChIP-Seq_U2OS_Human4.23706190
10* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.10694083
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.10480568
12CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.66152198
13NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.65607076
14* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.65213066
15* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.56488704
16* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.50532696
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.34164879
18CREB1_15753290_ChIP-ChIP_HEK293T_Human3.22745175
19GABP_17652178_ChIP-ChIP_JURKAT_Human3.18977254
20MYC_19079543_ChIP-ChIP_MESCs_Mouse3.00404292
21* CLOCK_20551151_ChIP-Seq_293T_Human2.98964176
22JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.94491700
23* EST1_17652178_ChIP-ChIP_JURKAT_Human2.93968557
24* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.90038569
25* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.90035323
26TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.86057085
27NELFA_20434984_ChIP-Seq_ESCs_Mouse2.73961050
28CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.73770718
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.69255767
30MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.65119928
31DCP1A_22483619_ChIP-Seq_HELA_Human2.58283746
32* ETS1_20019798_ChIP-Seq_JURKAT_Human2.52638651
33HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.27643885
34THAP11_20581084_ChIP-Seq_MESCs_Mouse2.26744698
35* XRN2_22483619_ChIP-Seq_HELA_Human2.25976481
36* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.23905006
37* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.16635083
38* ELK1_19687146_ChIP-ChIP_HELA_Human2.15889850
39PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.15744904
40NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.12864162
41* MYCN_18555785_ChIP-Seq_MESCs_Mouse2.12263860
42TP63_17297297_ChIP-ChIP_HaCaT_Human2.06329812
43E2F1_21310950_ChIP-Seq_MCF-7_Human2.05720690
44POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.02769544
45STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.00530405
46ZFX_18555785_ChIP-Seq_MESCs_Mouse2.00474346
47TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.98897446
48TTF2_22483619_ChIP-Seq_HELA_Human1.98751710
49ELF1_17652178_ChIP-ChIP_JURKAT_Human1.96727563
50GABP_19822575_ChIP-Seq_HepG2_Human1.89443542
51* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.88780885
52E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.84878035
53YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.84357617
54FOXP3_21729870_ChIP-Seq_TREG_Human1.81188940
55PADI4_21655091_ChIP-ChIP_MCF-7_Human1.79801024
56FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.78664542
57RARG_19884340_ChIP-ChIP_MEFs_Mouse1.78005217
58MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.76703036
59FOXA2_19822575_ChIP-Seq_HepG2_Human1.76341652
60VDR_23849224_ChIP-Seq_CD4+_Human1.74545228
61ZNF263_19887448_ChIP-Seq_K562_Human1.73946090
62PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.73094348
63NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.68609281
64ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.68542475
65FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.67305284
66HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.65668336
67MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.60279686
68NANOG_18555785_ChIP-Seq_MESCs_Mouse1.59207658
69HOXB4_20404135_ChIP-ChIP_EML_Mouse1.56671090
70GATA1_22025678_ChIP-Seq_K562_Human1.54963525
71* HNF4A_19822575_ChIP-Seq_HepG2_Human1.45679870
72GATA4_25053715_ChIP-Seq_YYC3_Human1.44774384
73SRF_21415370_ChIP-Seq_HL-1_Mouse1.44486925
74CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.42551143
75ESR2_21235772_ChIP-Seq_MCF-7_Human1.37847005
76* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.34470517
77DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.32612416
78SOX17_20123909_ChIP-Seq_XEN_Mouse1.30578593
79* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.30367893
80YY1_21170310_ChIP-Seq_MESCs_Mouse1.27051635
81CDX2_20551321_ChIP-Seq_CACO-2_Human1.26780974
82ESR1_21235772_ChIP-Seq_MCF-7_Human1.26630096
83ESR1_15608294_ChIP-ChIP_MCF-7_Human1.26011620
84GATA6_25053715_ChIP-Seq_YYC3_Human1.24247111
85POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.23745222
86FOXO3_23340844_ChIP-Seq_DLD1_Human1.21688685
87TRIM28_21343339_ChIP-Seq_HEK293_Human1.21677872
88E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.21365285
89RBPJ_22232070_ChIP-Seq_NCS_Mouse1.20440006
90HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.20126082
91* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.20020624
92CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.18707125
93ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.18605321
94HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.17614830
95* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.15958180
96CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.15762646
97KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.14530272
98SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.13090118
99* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.12244936
100CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.12074788
101KDM5A_27292631_Chip-Seq_BREAST_Human1.12008635
102PPAR_26484153_Chip-Seq_NCI-H1993_Human1.09458107
103LXR_22292898_ChIP-Seq_THP-1_Human1.08048326
104NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.07796366
105SALL4_18804426_ChIP-ChIP_XEN_Mouse1.07150896
106ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.06170789
107TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.06111610
108RACK7_27058665_Chip-Seq_MCF-7_Human1.05904325
109MYC_18940864_ChIP-ChIP_HL60_Human1.05896398
110SOX2_18555785_ChIP-Seq_MESCs_Mouse1.05667072
111* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.05142216
112NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.01752972
113BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01587317
114ELK1_22589737_ChIP-Seq_MCF10A_Human1.01359090
115ESR1_20079471_ChIP-ChIP_T-47D_Human1.01029959
116* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.00143888
117TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.99794062
118ATF3_27146783_Chip-Seq_COLON_Human0.99129284
119* SOX2_20726797_ChIP-Seq_SW620_Human0.98362409
120SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.98286404
121SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.97027392
122* ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.95650323
123CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.94243147
124BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.94203778
125FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.92960177
126KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.92252899
127AR_21909140_ChIP-Seq_LNCAP_Human0.92232418
128TFEB_21752829_ChIP-Seq_HELA_Human0.91663281
129NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.91588069
130NANOG_21062744_ChIP-ChIP_HESCs_Human0.90378401
131SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.90238246
132EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.89933673
133* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89859676
134TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.89769386
135ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.89480799
136NANOG_16153702_ChIP-ChIP_HESCs_Human0.89118623
137CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.88339010
138P300_27058665_Chip-Seq_ZR-75-30cells_Human0.88105273
139ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.86943396
140KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.86346004
141CREB1_26743006_Chip-Seq_LNCaP_Human0.83136285
142DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.82637788
143* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.82550228
144PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.81778899
145PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.80787651
146POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.80180324
147GATA3_24758297_ChIP-Seq_MCF-7_Human0.79955840
148GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.79791126
149HIF1A_21447827_ChIP-Seq_MCF-7_Human0.79725463
150ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.78251188
151* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.77953088
152SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.77495541
153PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.76971608
154THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.76963422
155RXRA_24833708_ChIP-Seq_LIVER_Mouse0.76650227
156RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.76635528
157ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.76229251
158STAT3_1855785_ChIP-Seq_MESCs_Mouse0.74771050
159FOXA1_25552417_ChIP-Seq_VCAP_Human0.72714254
160RARA_24833708_ChIP-Seq_LIVER_Mouse0.70686225
161NRF2_20460467_ChIP-Seq_MEFs_Mouse0.70250332
162NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.70250332
163TBX20_22328084_ChIP-Seq_HEART_Mouse0.69876585
164TBX20_22080862_ChIP-Seq_HEART_Mouse0.69876585
165SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.69730807
166FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.69319033
167GATA1_19941826_ChIP-Seq_K562_Human0.67085018
168TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.66347960
169CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.64870292
170RUNX1_27514584_Chip-Seq_MCF-7_Human0.64825977
171FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.64820386
172Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.64431586
173RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.63027252
174GATA2_19941826_ChIP-Seq_K562_Human0.62298836
175HTT_18923047_ChIP-ChIP_STHdh_Human0.61324524
176TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.61075035
177PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.60710619
178ELK3_25401928_ChIP-Seq_HUVEC_Human0.59407268
179CHD1_26751641_Chip-Seq_LNCaP_Human0.59132531
180PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.58822623
181RARB_24833708_ChIP-Seq_LIVER_Mouse0.55009383
182SOX9_24532713_ChIP-Seq_HFSC_Mouse0.54150974
183IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.53557542
184ZNF217_24962896_ChIP-Seq_MCF-7_Human0.53026901

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.47103586
2MP0005360_urolithiasis7.14184017
3MP0005085_abnormal_gallbladder_physiolo5.32585363
4MP0005365_abnormal_bile_salt5.29842528
5MP0010094_abnormal_chromosome_stability4.61008012
6MP0003693_abnormal_embryo_hatching4.35843343
7MP0008875_abnormal_xenobiotic_pharmacok4.31499263
8MP0004957_abnormal_blastocyst_morpholog4.30904575
9MP0003111_abnormal_nucleus_morphology4.07294220
10MP0003252_abnormal_bile_duct3.81933509
11MP0010329_abnormal_lipoprotein_level3.46747549
12MP0003077_abnormal_cell_cycle3.32011341
13MP0003806_abnormal_nucleotide_metabolis3.21762888
14MP0001666_abnormal_nutrient_absorption3.12710272
15MP0008058_abnormal_DNA_repair2.92588284
16MP0009840_abnormal_foam_cell2.85374576
17MP0008932_abnormal_embryonic_tissue2.82079976
18MP0005083_abnormal_biliary_tract2.66661224
19MP0005332_abnormal_amino_acid2.62708301
20MP0008007_abnormal_cellular_replicative2.60013105
21MP0003705_abnormal_hypodermis_morpholog2.55397856
22MP0003195_calcinosis2.41174547
23MP0008057_abnormal_DNA_replication2.40960676
24MP0003718_maternal_effect2.25289373
25MP0003941_abnormal_skin_development2.15202838
26MP0003315_abnormal_perineum_morphology2.10701693
27MP0002118_abnormal_lipid_homeostasis2.09475548
28MP0001730_embryonic_growth_arrest2.06947448
29MP0004019_abnormal_vitamin_homeostasis2.05818903
30MP0000609_abnormal_liver_physiology2.04749271
31MP0010234_abnormal_vibrissa_follicle2.00613337
32MP0000350_abnormal_cell_proliferation1.93538375
33MP0003191_abnormal_cellular_cholesterol1.88445906
34MP0001293_anophthalmia1.82478010
35MP0002138_abnormal_hepatobiliary_system1.77852280
36MP0001697_abnormal_embryo_size1.73804689
37MP0005319_abnormal_enzyme/_coenzyme1.71910356
38MP0009643_abnormal_urine_homeostasis1.67926109
39MP0003786_premature_aging1.67849533
40MP0001672_abnormal_embryogenesis/_devel1.66933082
41MP0005380_embryogenesis_phenotype1.66933082
42MP0003868_abnormal_feces_composition1.63341724
43MP0002080_prenatal_lethality1.57116769
44MP0002697_abnormal_eye_size1.56771762
45MP0003984_embryonic_growth_retardation1.48883411
46MP0003300_gastrointestinal_ulcer1.48822412
47MP0002088_abnormal_embryonic_growth/wei1.41851035
48MP0002084_abnormal_developmental_patter1.41810628
49MP0005584_abnormal_enzyme/coenzyme_acti1.41719150
50MP0006035_abnormal_mitochondrial_morpho1.40664707
51MP0005670_abnormal_white_adipose1.40360475
52MP0009379_abnormal_foot_pigmentation1.39117711
53MP0002085_abnormal_embryonic_tissue1.35639078
54MP0001529_abnormal_vocalization1.34643090
55MP0004043_abnormal_pH_regulation1.34021017
56MP0005257_abnormal_intraocular_pressure1.31242151
57MP0004130_abnormal_muscle_cell1.27527639
58MP0003937_abnormal_limbs/digits/tail_de1.26452462
59MP0004272_abnormal_basement_membrane1.25830583
60MP0001286_abnormal_eye_development1.23661722
61MP0002086_abnormal_extraembryonic_tissu1.21908747
62MP0003123_paternal_imprinting1.21600355
63MP0010030_abnormal_orbit_morphology1.21366262
64MP0005666_abnormal_adipose_tissue1.20968202
65MP0001346_abnormal_lacrimal_gland1.19810003
66MP0000358_abnormal_cell_content/1.19747788
67MP0002233_abnormal_nose_morphology1.18280406
68MP0002092_abnormal_eye_morphology1.18176253
69MP0004197_abnormal_fetal_growth/weight/1.18041328
70MP0001764_abnormal_homeostasis1.17286126
71MP0000313_abnormal_cell_death1.16342302
72MP0004264_abnormal_extraembryonic_tissu1.16010891
73MP0000762_abnormal_tongue_morphology1.15749756
74MP0001756_abnormal_urination1.15722623
75MP0000598_abnormal_liver_morphology1.13971926
76MP0005501_abnormal_skin_physiology1.12790875
77MP0003890_abnormal_embryonic-extraembry1.12490841
78MP0003186_abnormal_redox_activity1.11917295
79MP0005220_abnormal_exocrine_pancreas1.10951182
80MP0002078_abnormal_glucose_homeostasis1.08489130
81MP0005636_abnormal_mineral_homeostasis1.07297037
82MP0002938_white_spotting1.06349400
83MP0009780_abnormal_chondrocyte_physiolo1.04763670
84MP0000490_abnormal_crypts_of1.02963966
85MP0002234_abnormal_pharynx_morphology1.02349773
86MP0003385_abnormal_body_wall1.02235664
87MP0002111_abnormal_tail_morphology1.01792783
88MP0004185_abnormal_adipocyte_glucose0.97729589
89MP0002160_abnormal_reproductive_system0.97045844
90MP0002971_abnormal_brown_adipose0.92335908
91MP0005334_abnormal_fat_pad0.91433638
92MP0005084_abnormal_gallbladder_morpholo0.91386980
93MP0000604_amyloidosis0.90814273
94MP0002876_abnormal_thyroid_physiology0.88768206
95MP0003567_abnormal_fetal_cardiomyocyte0.88507014
96MP0009053_abnormal_anal_canal0.88471295
97MP0010352_gastrointestinal_tract_polyps0.88104577
98MP0002909_abnormal_adrenal_gland0.87895216
99MP0003119_abnormal_digestive_system0.86935156
100MP0000627_abnormal_mammary_gland0.85949502
101MP0010307_abnormal_tumor_latency0.85712944
102MP0001915_intracranial_hemorrhage0.83497857
103MP0009642_abnormal_blood_homeostasis0.83412870
104MP0003943_abnormal_hepatobiliary_system0.83127561
105MP0005375_adipose_tissue_phenotype0.82711866
106MP0005448_abnormal_energy_balance0.82584006
107MP0006292_abnormal_olfactory_placode0.81987651
108MP0006072_abnormal_retinal_apoptosis0.81919787
109MP0005647_abnormal_sex_gland0.81295521
110MP0002210_abnormal_sex_determination0.79715358
111MP0005408_hypopigmentation0.79280905
112MP0010368_abnormal_lymphatic_system0.78317174
113MP0000566_synostosis0.77551744
114MP0001765_abnormal_ion_homeostasis0.76161960
115MP0002019_abnormal_tumor_incidence0.75914039
116MP0003283_abnormal_digestive_organ0.75568304
117MP0002254_reproductive_system_inflammat0.75281710
118MP0002136_abnormal_kidney_physiology0.74652922
119MP0008438_abnormal_cutaneous_collagen0.73594922
120MP0003221_abnormal_cardiomyocyte_apopto0.73188502
121MP0001944_abnormal_pancreas_morphology0.72906011
122MP0005535_abnormal_body_temperature0.72859692
123MP0001929_abnormal_gametogenesis0.72815812
124MP0004233_abnormal_muscle_weight0.72451248
125MP0000537_abnormal_urethra_morphology0.72411206
126MP0001727_abnormal_embryo_implantation0.72380893
127MP0002877_abnormal_melanocyte_morpholog0.72096557
128MP0002089_abnormal_postnatal_growth/wei0.71958527
129MP0009697_abnormal_copulation0.71714814
130MP0003121_genomic_imprinting0.71425689
131MP0002006_tumorigenesis0.71355267
132MP0005384_cellular_phenotype0.70377254
133MP0009763_increased_sensitivity_to0.69381391
134MP0010678_abnormal_skin_adnexa0.68677350
135MP0001661_extended_life_span0.68099146
136MP0005391_vision/eye_phenotype0.68028410
137MP0001145_abnormal_male_reproductive0.67364187
138MP0002796_impaired_skin_barrier0.65679956
139MP0009764_decreased_sensitivity_to0.65288516
140MP0001340_abnormal_eyelid_morphology0.64940765
141MP0005058_abnormal_lysosome_morphology0.64394331
142MP0008961_abnormal_basal_metabolism0.64340932
143MP0003959_abnormal_lean_body0.64027986
144MP0003656_abnormal_erythrocyte_physiolo0.62776524
145MP0001881_abnormal_mammary_gland0.62158493
146MP0003953_abnormal_hormone_level0.61651733
147MP0000013_abnormal_adipose_tissue0.61426358
148MP0000653_abnormal_sex_gland0.61239525
149MP0002928_abnormal_bile_duct0.61140057
150MP0003329_amyloid_beta_deposits0.61020609
151MP0000003_abnormal_adipose_tissue0.60715156
152MP0003699_abnormal_female_reproductive0.60300751
153MP0005451_abnormal_body_composition0.59985482
154MP0008469_abnormal_protein_level0.59982046
155MP0004782_abnormal_surfactant_physiolog0.59832972
156MP0005376_homeostasis/metabolism_phenot0.59670890
157MP0005248_abnormal_Harderian_gland0.59095031
158MP0006036_abnormal_mitochondrial_physio0.58996080
159MP0002970_abnormal_white_adipose0.58889583
160MP0009115_abnormal_fat_cell0.57741525
161MP0009672_abnormal_birth_weight0.57350854
162MP0009765_abnormal_xenobiotic_induced0.56816155
163MP0009384_cardiac_valve_regurgitation0.56431852
164MP0005167_abnormal_blood-brain_barrier0.56312598
165MP0002896_abnormal_bone_mineralization0.55213727
166MP0000639_abnormal_adrenal_gland0.55062620
167MP0002168_other_aberrant_phenotype0.53139421
168MP0005266_abnormal_metabolism0.52658350
169MP0000538_abnormal_urinary_bladder0.51766631
170MP0005187_abnormal_penis_morphology0.50972923
171MP0002837_dystrophic_cardiac_calcinosis0.49410737
172MP0003638_abnormal_response/metabolism_0.49170551
173MP0000230_abnormal_systemic_arterial0.48676984
174MP0003566_abnormal_cell_adhesion0.48285811
175MP0000462_abnormal_digestive_system0.47953185

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)5.99918081
2Deep venous thrombosis (HP:0002625)5.84886287
3Abnormality of aromatic amino acid family metabolism (HP:0004338)5.69936587
4Abnormality of monocarboxylic acid metabolism (HP:0010996)5.55749068
5Xanthomatosis (HP:0000991)5.54880232
6Hypobetalipoproteinemia (HP:0003563)5.41795647
7Abnormality of glutamine family amino acid metabolism (HP:0010902)4.47923409
8Hypoglycemic coma (HP:0001325)4.37872810
9Abnormality of glycolysis (HP:0004366)4.31824560
10Ketosis (HP:0001946)4.27326208
11Hyperglycinuria (HP:0003108)4.26223957
12Complement deficiency (HP:0004431)4.23507552
13Increased serum pyruvate (HP:0003542)4.23233507
14Chromosomal breakage induced by crosslinking agents (HP:0003221)4.22310991
15Prolonged partial thromboplastin time (HP:0003645)4.20329279
16Epidermoid cyst (HP:0200040)4.20075510
17Hyperammonemia (HP:0001987)4.11346450
18Chromsome breakage (HP:0040012)4.09346705
19Hypolipoproteinemia (HP:0010981)4.08760799
20Abnormality of serine family amino acid metabolism (HP:0010894)4.02386612
21Abnormality of glycine metabolism (HP:0010895)4.02386612
22Hyperlipoproteinemia (HP:0010980)3.98359565
23Hyperglycinemia (HP:0002154)3.83378009
24Ketoacidosis (HP:0001993)3.77062336
25Abnormality of the common coagulation pathway (HP:0010990)3.74937760
26Fat malabsorption (HP:0002630)3.71933549
27Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.66249315
28Abnormality of sulfur amino acid metabolism (HP:0004339)3.62774640
29Microvesicular hepatic steatosis (HP:0001414)3.55836936
30Abnormality of the intrinsic pathway (HP:0010989)3.48589696
31Hypoalphalipoproteinemia (HP:0003233)3.44381044
32Conjugated hyperbilirubinemia (HP:0002908)3.32712829
33Abnormality of aspartate family amino acid metabolism (HP:0010899)3.26989715
34Gout (HP:0001997)3.26793301
35Abnormality of purine metabolism (HP:0004352)3.25035287
36Abnormality of fatty-acid metabolism (HP:0004359)3.17205437
37Increased hepatocellular lipid droplets (HP:0006565)3.15267454
38Meckel diverticulum (HP:0002245)3.13429122
39Hypercholesterolemia (HP:0003124)3.10727085
40Abnormality of complement system (HP:0005339)3.08712311
41Abnormality of nucleobase metabolism (HP:0010932)3.06451194
42Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.04327929
43Joint hemorrhage (HP:0005261)3.04317538
44Hypoglycemic seizures (HP:0002173)3.02488191
45Skin nodule (HP:0200036)2.98362307
46Abnormality of the ileum (HP:0001549)2.96818675
47Multiple enchondromatosis (HP:0005701)2.88232531
48Abnormal lung lobation (HP:0002101)2.87816195
49Spastic diplegia (HP:0001264)2.84958784
50Abnormality of the preputium (HP:0100587)2.84223126
51Hepatocellular carcinoma (HP:0001402)2.81779512
52Reduced antithrombin III activity (HP:0001976)2.80117321
53Hydroxyprolinuria (HP:0003080)2.77208558
54Abnormality of proline metabolism (HP:0010907)2.77208558
55Lipid accumulation in hepatocytes (HP:0006561)2.75029439
56Microglossia (HP:0000171)2.73816928
57Myocardial infarction (HP:0001658)2.72494173
58Type I transferrin isoform profile (HP:0003642)2.71581816
59Abnormality of methionine metabolism (HP:0010901)2.69897084
60Late onset (HP:0003584)2.69736708
61Abnormality of pyrimidine metabolism (HP:0004353)2.69283008
62Reticulocytopenia (HP:0001896)2.68098772
63Hyperbilirubinemia (HP:0002904)2.67503116
64Delayed CNS myelination (HP:0002188)2.65177259
65Hyperinsulinemic hypoglycemia (HP:0000825)2.62752666
66Increased nuchal translucency (HP:0010880)2.56759076
67Acanthocytosis (HP:0001927)2.56375601
68Malnutrition (HP:0004395)2.55333146
69Nephroblastoma (Wilms tumor) (HP:0002667)2.52622826
70Abnormal cartilage morphology (HP:0002763)2.49713806
71Hypoplasia of the capital femoral epiphysis (HP:0003090)2.49139817
72Metabolic acidosis (HP:0001942)2.46667310
73Abnormality of chromosome stability (HP:0003220)2.44338699
74Steatorrhea (HP:0002570)2.44135124
75Progressive external ophthalmoplegia (HP:0000590)2.43615112
76Proximal placement of thumb (HP:0009623)2.41960013
77Aplasia/Hypoplasia of the uvula (HP:0010293)2.39185810
78Embryonal renal neoplasm (HP:0011794)2.36258321
79Progressive muscle weakness (HP:0003323)2.33897430
80Amniotic constriction ring (HP:0009775)2.33055501
81Abnormality of placental membranes (HP:0011409)2.33055501
82Deviation of the thumb (HP:0009603)2.31363299
83Abnormality of serum amino acid levels (HP:0003112)2.30636680
84Neonatal onset (HP:0003623)2.29177269
85Esophageal varix (HP:0002040)2.28365047
86Sensorimotor neuropathy (HP:0007141)2.26928440
87Generalized aminoaciduria (HP:0002909)2.26629835
88Macrocytic anemia (HP:0001972)2.24257101
89Increased serum lactate (HP:0002151)2.24248929
90Dicarboxylic aciduria (HP:0003215)2.23478988
91Abnormality of dicarboxylic acid metabolism (HP:0010995)2.23478988
92Duodenal stenosis (HP:0100867)2.22325108
93Small intestinal stenosis (HP:0012848)2.22325108
94Hyperglycemia (HP:0003074)2.22086411
95Hyperuricemia (HP:0002149)2.21832706
96Increased purine levels (HP:0004368)2.21832706
97Sparse eyelashes (HP:0000653)2.19354846
98Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.19313485
99Decreased activity of mitochondrial respiratory chain (HP:0008972)2.19313485
100Pancreatitis (HP:0001733)2.19175027
101Selective tooth agenesis (HP:0001592)2.18332810
102Irritability (HP:0000737)2.17973669
103Symptomatic seizures (HP:0011145)2.17685550
104Vascular calcification (HP:0004934)2.14104929
105Small epiphyses (HP:0010585)2.13660008
106Insomnia (HP:0100785)2.13620509
107Aplastic anemia (HP:0001915)2.11754764
108Back pain (HP:0003418)2.11715347
109Increased CSF lactate (HP:0002490)2.11346828
110Abnormal gallbladder morphology (HP:0012437)2.08245534
111Abnormal protein glycosylation (HP:0012346)2.08241285
112Abnormal glycosylation (HP:0012345)2.08241285
113Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.08241285
114Abnormal protein N-linked glycosylation (HP:0012347)2.08241285
115Megaloblastic anemia (HP:0001889)2.06679083
116Postnatal microcephaly (HP:0005484)2.06315107
117Hepatocellular necrosis (HP:0001404)2.05027016
118Proximal tubulopathy (HP:0000114)2.04777495
119Hepatic necrosis (HP:0002605)2.04718082
120Acute necrotizing encephalopathy (HP:0006965)2.03553973
121Abnormal mitochondria in muscle tissue (HP:0008316)2.03164206
122Cardiovascular calcification (HP:0011915)2.02579607
123Overlapping toe (HP:0001845)2.01945468
124Mitral stenosis (HP:0001718)2.00249977
125Lethargy (HP:0001254)1.99558116
126Cholelithiasis (HP:0001081)1.98573371
127Lactic acidosis (HP:0003128)1.98043463
128Aplasia/Hypoplasia of the sacrum (HP:0008517)1.97960187
129Hemorrhage of the eye (HP:0011885)1.97955402
130Abnormality of the carotid arteries (HP:0005344)1.97638721
131Acute encephalopathy (HP:0006846)1.96721057
132Abnormal enzyme/coenzyme activity (HP:0012379)1.96114009
133Cholecystitis (HP:0001082)1.95655992
134Abnormal gallbladder physiology (HP:0012438)1.95655992
135Missing ribs (HP:0000921)1.95416968
136Abnormalities of placenta or umbilical cord (HP:0001194)1.95208681
137Cerebral edema (HP:0002181)1.92626470
138Facial cleft (HP:0002006)1.92313014
139Rough bone trabeculation (HP:0100670)1.92294027
140Nephrolithiasis (HP:0000787)1.91158446
141Neoplasm of the colon (HP:0100273)1.91153731
142Lymphangioma (HP:0100764)1.91068711
143Turricephaly (HP:0000262)1.90957954
144Systemic lupus erythematosus (HP:0002725)1.90951123
145Abnormality of the anterior horn cell (HP:0006802)1.90913946
146Degeneration of anterior horn cells (HP:0002398)1.90913946
147Mitochondrial inheritance (HP:0001427)1.90822435
148Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.90787047
149Absent epiphyses (HP:0010577)1.90787047
150Alkalosis (HP:0001948)1.89999508
151Pancreatic islet-cell hyperplasia (HP:0004510)1.85826805
152Abnormal tarsal ossification (HP:0008369)1.84949216
153Insulin resistance (HP:0000855)1.84652219
154Poikiloderma (HP:0001029)1.84607147
155Horseshoe kidney (HP:0000085)1.83959068
156Increased intramyocellular lipid droplets (HP:0012240)1.83071400
157Irregular epiphyses (HP:0010582)1.82374540
158Premature ovarian failure (HP:0008209)1.81825344
159Rickets (HP:0002748)1.81561002
160Ileus (HP:0002595)1.81550914
161Myelodysplasia (HP:0002863)1.81110134
162Secondary amenorrhea (HP:0000869)1.81067090
163Abnormality of the Achilles tendon (HP:0005109)1.80697744
164Vomiting (HP:0002013)1.80407508
165Spontaneous abortion (HP:0005268)1.80113209
166Hypoplastic pelvis (HP:0008839)1.79113793
167Abnormality of cells of the erythroid lineage (HP:0012130)1.77539099
168Cortical dysplasia (HP:0002539)1.77040535
169Bifid tongue (HP:0010297)1.76977428
170Abnormality of the gallbladder (HP:0005264)1.76809948
171Brushfield spots (HP:0001088)1.76275481
172Neoplasm of the adrenal gland (HP:0100631)1.75950053
173Myoglobinuria (HP:0002913)1.75753833
17411 pairs of ribs (HP:0000878)1.75724664
175Abnormality of alkaline phosphatase activity (HP:0004379)1.74550692
176Glomerulosclerosis (HP:0000096)1.74010672
177Abnormality of endocrine pancreas physiology (HP:0012093)1.73177944
178Abnormality of the pancreatic islet cells (HP:0006476)1.73177944
179Glycosuria (HP:0003076)1.70157655
180Abnormality of urine glucose concentration (HP:0011016)1.70157655
181Elevated alkaline phosphatase (HP:0003155)1.70019539
182Exercise intolerance (HP:0003546)1.68322570
183Abnormality of the duodenum (HP:0002246)1.68319012
184Birth length less than 3rd percentile (HP:0003561)1.68075067
185Colon cancer (HP:0003003)1.66994296
186Absent radius (HP:0003974)1.65536139
187Trismus (HP:0000211)1.65401259
188Renal Fanconi syndrome (HP:0001994)1.64065946
189Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.62319866
190Confusion (HP:0001289)1.61813058

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.34413033
2BCKDK4.32802800
3TRIB34.18012781
4PBK4.00670042
5ERN13.88181164
6SIK13.69109038
7MST43.50170370
8PKN23.42536687
9FRK3.29861085
10SRPK13.18055743
11VRK23.14217525
12CDC72.73323239
13EIF2AK12.73184478
14TTK2.66248522
15TSSK62.55702130
16FGFR42.50056142
17PTK62.33999535
18MST1R2.33073977
19WEE12.24773036
20INSRR2.22785123
21RIPK12.19263840
22LATS12.18658874
23TAOK32.18510157
24EIF2AK32.05070265
25NME21.98917441
26PLK31.74836033
27SCYL21.73876708
28MAP3K101.66482807
29MAP3K21.65842411
30PDGFRA1.62173618
31CAMK1D1.61866113
32LMTK21.61528532
33MAP3K121.60209119
34FLT31.59935599
35PLK41.53270456
36STK161.49198160
37STK391.44652547
38TAF11.43308876
39BRSK21.42241376
40EEF2K1.38175004
41PLK11.36520469
42BRSK11.36509771
43ERBB41.36509076
44MET1.35955065
45NME11.34959634
46ZAK1.32582495
47PTK21.30796097
48FGFR21.30518615
49NEK21.25958239
50VRK11.24773266
51LRRK21.24083119
52KSR21.20922344
53CCNB11.20673522
54AURKB1.19884243
55CDK71.18220324
56CHEK21.16328338
57BCR1.16136953
58MKNK11.15614947
59TRIM281.15042171
60CAMK1G1.09033278
61MAPK111.04926241
62CDK81.03117085
63NEK11.01394983
64EPHA21.00754001
65NEK91.00144823
66CDK60.98058686
67RET0.97467360
68WNK40.96880610
69SMG10.96113490
70ATR0.95772737
71FER0.95645695
72LIMK10.94981409
73EIF2AK20.94007441
74TNIK0.91583271
75PDK40.91510806
76PDK30.91510806
77MAP2K10.90972738
78TESK10.90936115
79JAK20.87647900
80LATS20.84218821
81MAP3K70.84142337
82MAP2K40.83876939
83BMX0.83220129
84EPHB20.83144286
85CSNK1A1L0.81769139
86PAK30.81397115
87MTOR0.80550814
88DAPK20.80279939
89TTN0.78458987
90CHEK10.78162400
91DYRK1B0.77829604
92MAP2K20.77299330
93PRKD30.76094340
94PASK0.74567560
95PIK3CG0.74226029
96PRKAA20.73058393
97ERBB20.72664356
98ERBB30.71916567
99CAMKK10.71798438
100FGFR10.70986095
101DAPK10.70930431
102KDR0.70676610
103NTRK10.69938173
104RPS6KB20.69472489
105PRKG20.68609174
106PRKAA10.68202204
107NUAK10.68065092
108PAK20.67315940
109FGFR30.67133178
110MKNK20.66750861
111ABL20.66690224
112DDR20.66013239
113AKT20.65835549
114BRD40.65518538
115AURKA0.65487737
116JAK10.65420761
117ALK0.64326995
118GSK3A0.63361129
119GRK60.63035355
120CSNK1G30.62476016
121MAP3K30.60658502
122STK38L0.57836231
123EPHB10.56858652
124MAP3K10.56372785
125MAP3K80.55902249
126PDPK10.55744036
127ATM0.55651476
128CSNK2A20.54967515
129PNCK0.54206318
130CSNK1G10.53723943
131CDK90.53474401
132STK30.53416431
133PAK40.50897758
134STK40.50621452
135TYK20.50311791
136CDK180.48905589
137STK100.48213826
138PRKACG0.48095008
139PDGFRB0.48035831
140MAPKAPK30.46553829
141PRKCZ0.46430525
142MELK0.45981270
143CSNK2A10.45708691
144AKT30.45275098
145CDK140.44587962
146CDK40.44173957
147CDK150.43929605
148CDK120.43600332
149TESK20.42847417
150MAP2K30.42727452
151CDK10.42379081
152PRKCH0.42223944
153CDK11A0.40908396
154RPS6KA40.40808640
155SGK30.40126268
156PDK20.39672081
157TAOK10.38921957
158CSNK1E0.38805847
159MAPKAPK50.38582248
160TIE10.37953398
161ARAF0.36346049
162PDK10.36029575
163ICK0.35805917
164IGF1R0.34854451
165MAP3K90.34392351
166CSNK1G20.33922893
167CDK20.33022328
168EGFR0.32892460
169BMPR1B0.31860859
170NEK60.28787988
171PRKD10.28190358
172WNK30.27962537
173TBK10.27585610
174EPHA30.25143725
175MAP3K110.24347543

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.90048403
2DNA replication_Homo sapiens_hsa030303.82160612
3Nitrogen metabolism_Homo sapiens_hsa009103.65850393
4Primary bile acid biosynthesis_Homo sapiens_hsa001203.60666273
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.35053464
6Mismatch repair_Homo sapiens_hsa034303.16820040
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.85185510
8Non-homologous end-joining_Homo sapiens_hsa034502.76944055
9Arginine biosynthesis_Homo sapiens_hsa002202.76664605
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.69733962
11Fatty acid degradation_Homo sapiens_hsa000712.67422900
12Tryptophan metabolism_Homo sapiens_hsa003802.65924264
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.64333861
14Spliceosome_Homo sapiens_hsa030402.61870715
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.61044354
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.59507931
17Ribosome_Homo sapiens_hsa030102.39264696
18Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.37766540
19Nucleotide excision repair_Homo sapiens_hsa034202.29646973
20Base excision repair_Homo sapiens_hsa034102.28339530
21Butanoate metabolism_Homo sapiens_hsa006502.24600109
22Propanoate metabolism_Homo sapiens_hsa006402.19655511
23Pentose and glucuronate interconversions_Homo sapiens_hsa000402.18176406
24RNA polymerase_Homo sapiens_hsa030202.16055039
25Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.10394251
26RNA transport_Homo sapiens_hsa030132.09753805
27PPAR signaling pathway_Homo sapiens_hsa033202.09242245
28Fatty acid metabolism_Homo sapiens_hsa012122.05823567
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.99942326
30Homologous recombination_Homo sapiens_hsa034401.99811744
31Complement and coagulation cascades_Homo sapiens_hsa046101.96467628
32Cell cycle_Homo sapiens_hsa041101.96386204
33Fat digestion and absorption_Homo sapiens_hsa049751.86693064
34Sulfur metabolism_Homo sapiens_hsa009201.86276270
35Peroxisome_Homo sapiens_hsa041461.86216171
36Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.78448742
37Caffeine metabolism_Homo sapiens_hsa002321.74499300
38Protein export_Homo sapiens_hsa030601.74142068
39Pyrimidine metabolism_Homo sapiens_hsa002401.72764654
40Bile secretion_Homo sapiens_hsa049761.68438039
41Maturity onset diabetes of the young_Homo sapiens_hsa049501.67788847
42Pyruvate metabolism_Homo sapiens_hsa006201.65056138
43Selenocompound metabolism_Homo sapiens_hsa004501.62536991
44Histidine metabolism_Homo sapiens_hsa003401.60886575
45Fanconi anemia pathway_Homo sapiens_hsa034601.60507496
46beta-Alanine metabolism_Homo sapiens_hsa004101.59422894
47Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.56664476
48Chemical carcinogenesis_Homo sapiens_hsa052041.56073905
49Starch and sucrose metabolism_Homo sapiens_hsa005001.54026286
50Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.53454926
51Drug metabolism - other enzymes_Homo sapiens_hsa009831.52170249
52Steroid hormone biosynthesis_Homo sapiens_hsa001401.52102775
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.44330772
54Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.43787285
55Carbon metabolism_Homo sapiens_hsa012001.40818619
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.38965008
57Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.37397678
58Phenylalanine metabolism_Homo sapiens_hsa003601.35546495
59Oxidative phosphorylation_Homo sapiens_hsa001901.33611763
60Biosynthesis of amino acids_Homo sapiens_hsa012301.30334463
61RNA degradation_Homo sapiens_hsa030181.29186724
62Parkinsons disease_Homo sapiens_hsa050121.28389335
63Retinol metabolism_Homo sapiens_hsa008301.26900204
64mRNA surveillance pathway_Homo sapiens_hsa030151.18916740
65Tyrosine metabolism_Homo sapiens_hsa003501.18355764
66Folate biosynthesis_Homo sapiens_hsa007901.14377574
67Basal transcription factors_Homo sapiens_hsa030221.13065067
68ABC transporters_Homo sapiens_hsa020101.10065800
69Purine metabolism_Homo sapiens_hsa002301.08251901
70Cyanoamino acid metabolism_Homo sapiens_hsa004601.07605835
71Fatty acid biosynthesis_Homo sapiens_hsa000611.03922389
72Staphylococcus aureus infection_Homo sapiens_hsa051501.03223944
73Cysteine and methionine metabolism_Homo sapiens_hsa002701.02873078
74Steroid biosynthesis_Homo sapiens_hsa001001.02386337
75Vitamin digestion and absorption_Homo sapiens_hsa049771.01582986
76Glycerolipid metabolism_Homo sapiens_hsa005611.00491484
77Huntingtons disease_Homo sapiens_hsa050160.98281644
78Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.96322619
79Lysine degradation_Homo sapiens_hsa003100.93374933
80Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.84417554
81Fatty acid elongation_Homo sapiens_hsa000620.84045757
82Arginine and proline metabolism_Homo sapiens_hsa003300.83910365
83p53 signaling pathway_Homo sapiens_hsa041150.82629748
84Oocyte meiosis_Homo sapiens_hsa041140.80916024
85Alzheimers disease_Homo sapiens_hsa050100.77102441
86Glutathione metabolism_Homo sapiens_hsa004800.70798034
87Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.70378699
88Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.66646448
89Sulfur relay system_Homo sapiens_hsa041220.66256660
90Pentose phosphate pathway_Homo sapiens_hsa000300.64924801
91Thyroid cancer_Homo sapiens_hsa052160.64055051
92Galactose metabolism_Homo sapiens_hsa000520.63824675
93One carbon pool by folate_Homo sapiens_hsa006700.61437213
94Insulin resistance_Homo sapiens_hsa049310.57832389
95Hippo signaling pathway_Homo sapiens_hsa043900.57180676
96Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.56676552
97Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56299775
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52961855
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.49371411
100Basal cell carcinoma_Homo sapiens_hsa052170.48816492
101Adherens junction_Homo sapiens_hsa045200.48578654
102Fructose and mannose metabolism_Homo sapiens_hsa000510.47464896
103Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46043255
104Renin-angiotensin system_Homo sapiens_hsa046140.44803470
105Vibrio cholerae infection_Homo sapiens_hsa051100.44676344
106Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.44547009
107Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.42967566
108Vitamin B6 metabolism_Homo sapiens_hsa007500.41632696
109Carbohydrate digestion and absorption_Homo sapiens_hsa049730.41031227
110AMPK signaling pathway_Homo sapiens_hsa041520.36769173
111Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.35334084
112Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.34883962
113Epstein-Barr virus infection_Homo sapiens_hsa051690.32939342
114Glucagon signaling pathway_Homo sapiens_hsa049220.31539113
115Metabolic pathways_Homo sapiens_hsa011000.31472251
116Wnt signaling pathway_Homo sapiens_hsa043100.30291708
117Prion diseases_Homo sapiens_hsa050200.28059638
118Protein digestion and absorption_Homo sapiens_hsa049740.28032310
119Hedgehog signaling pathway_Homo sapiens_hsa043400.27024314
120TGF-beta signaling pathway_Homo sapiens_hsa043500.26588967
121Mineral absorption_Homo sapiens_hsa049780.26380834
122Small cell lung cancer_Homo sapiens_hsa052220.23239241
123Central carbon metabolism in cancer_Homo sapiens_hsa052300.22239571
124Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.21627275
125Insulin signaling pathway_Homo sapiens_hsa049100.20967549
126Tight junction_Homo sapiens_hsa045300.20001554
127Systemic lupus erythematosus_Homo sapiens_hsa053220.19966004
128Bladder cancer_Homo sapiens_hsa052190.19806581
129Viral carcinogenesis_Homo sapiens_hsa052030.19352273
130Shigellosis_Homo sapiens_hsa051310.19321722
131Thyroid hormone synthesis_Homo sapiens_hsa049180.19026813
132alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.18890462
133Type II diabetes mellitus_Homo sapiens_hsa049300.15995397
134Glycerophospholipid metabolism_Homo sapiens_hsa005640.10705863
135Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.07317945
136Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.05191286
137Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.03724613
138Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.02935294
139N-Glycan biosynthesis_Homo sapiens_hsa005100.00777542
140Longevity regulating pathway - mammal_Homo sapiens_hsa042110.00190828
141Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0525516
142Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.0509706
143Linoleic acid metabolism_Homo sapiens_hsa00591-0.0501473
144Lysosome_Homo sapiens_hsa04142-0.0459306
145mTOR signaling pathway_Homo sapiens_hsa04150-0.0440236
146Amoebiasis_Homo sapiens_hsa05146-0.0324012
147Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0320626

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