CYB5R1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1muscle filament sliding (GO:0030049)8.93871155
2actin-myosin filament sliding (GO:0033275)8.93871155
3actin-mediated cell contraction (GO:0070252)7.42320318
4skeletal muscle contraction (GO:0003009)7.34811478
5sarcoplasmic reticulum calcium ion transport (GO:0070296)6.72352346
6regulation of skeletal muscle contraction (GO:0014819)6.50368567
7actin filament-based movement (GO:0030048)5.62100627
8striated muscle contraction (GO:0006941)5.25959112
9positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.24463140
10response to muscle activity (GO:0014850)5.05125865
11ribosomal small subunit assembly (GO:0000028)5.02037065
12sarcomere organization (GO:0045214)5.00588011
13response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.74985070
14myofibril assembly (GO:0030239)4.74014594
15regulation of relaxation of muscle (GO:1901077)4.60725731
16formation of translation preinitiation complex (GO:0001731)4.59127411
17skeletal muscle fiber development (GO:0048741)4.58805603
18viral transcription (GO:0019083)4.57184225
19maturation of SSU-rRNA (GO:0030490)4.56655255
20translational termination (GO:0006415)4.50285461
21plasma membrane repair (GO:0001778)4.34082379
22response to inactivity (GO:0014854)4.32555054
23cardiac muscle contraction (GO:0060048)4.19948323
24translational elongation (GO:0006414)4.19075451
25ribosomal large subunit biogenesis (GO:0042273)4.16967053
26negative regulation of protein localization to cell surface (GO:2000009)4.16697890
27creatine metabolic process (GO:0006600)4.14853886
28ribosomal small subunit biogenesis (GO:0042274)4.10982001
29regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.10372097
30myotube cell development (GO:0014904)4.09612135
31muscle contraction (GO:0006936)4.04660149
32positive regulation of mitochondrial calcium ion concentration (GO:0051561)4.01856894
33translational initiation (GO:0006413)4.00994614
34regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.98948052
35IMP biosynthetic process (GO:0006188)3.98524816
36glycogen catabolic process (GO:0005980)3.88610426
37cardiac myofibril assembly (GO:0055003)3.88346290
38SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.86783903
39skeletal muscle adaptation (GO:0043501)3.86390678
40muscle cell cellular homeostasis (GO:0046716)3.85122007
41negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.84776132
42regulation of gene silencing by RNA (GO:0060966)3.81656528
43regulation of posttranscriptional gene silencing (GO:0060147)3.81656528
44regulation of gene silencing by miRNA (GO:0060964)3.81656528
45NADH metabolic process (GO:0006734)3.81089888
46regulation of translational fidelity (GO:0006450)3.78750826
47protein targeting to ER (GO:0045047)3.76310583
48cotranslational protein targeting to membrane (GO:0006613)3.74972700
49DNA strand elongation involved in DNA replication (GO:0006271)3.73175649
50actomyosin structure organization (GO:0031032)3.70978788
51nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.70463398
52IMP metabolic process (GO:0046040)3.67046179
53muscle system process (GO:0003012)3.65647366
54glucan catabolic process (GO:0009251)3.61000942
55cellular protein complex disassembly (GO:0043624)3.59421608
56establishment of protein localization to endoplasmic reticulum (GO:0072599)3.58864346
57heart process (GO:0003015)3.58124587
58heart contraction (GO:0060047)3.58124587
59viral life cycle (GO:0019058)3.57824151
60negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.57124630
61cellular polysaccharide catabolic process (GO:0044247)3.54955031
62telomere maintenance via semi-conservative replication (GO:0032201)3.53665579
63DNA strand elongation (GO:0022616)3.49635914
64skeletal muscle tissue development (GO:0007519)3.48197201
65hemidesmosome assembly (GO:0031581)3.47941142
66protein localization to endoplasmic reticulum (GO:0070972)3.47111331
67DNA replication initiation (GO:0006270)3.45921003
68ribonucleoprotein complex biogenesis (GO:0022613)3.44586875
69striated muscle atrophy (GO:0014891)3.44246824
70DNA deamination (GO:0045006)3.38378757
71muscle cell fate commitment (GO:0042693)3.38306996
72negative regulation of potassium ion transmembrane transport (GO:1901380)3.32518345
73positive regulation of myotube differentiation (GO:0010831)3.31590876
74glycogen biosynthetic process (GO:0005978)3.30986839
75glucan biosynthetic process (GO:0009250)3.30986839
76skeletal muscle tissue regeneration (GO:0043403)3.29419622
77DNA unwinding involved in DNA replication (GO:0006268)3.29316842
78polysaccharide catabolic process (GO:0000272)3.26284375
79positive regulation of SMAD protein import into nucleus (GO:0060391)3.23499923
80folic acid-containing compound biosynthetic process (GO:0009396)3.21140651
81regulation of integrin-mediated signaling pathway (GO:2001044)3.20781525
82myoblast fusion (GO:0007520)3.20780492
83telomere maintenance via recombination (GO:0000722)3.19997081
84nucleobase biosynthetic process (GO:0046112)3.18322635
85regulation of cell communication by electrical coupling (GO:0010649)3.18029775
86tRNA aminoacylation (GO:0043039)3.17962853
87amino acid activation (GO:0043038)3.17962853
88protein complex disassembly (GO:0043241)3.17446422
89muscle fiber development (GO:0048747)3.16948002
90regulation of striated muscle contraction (GO:0006942)3.16374948
91translation (GO:0006412)3.15653347
92regulation of SMAD protein import into nucleus (GO:0060390)3.14861816
93mitotic nuclear envelope disassembly (GO:0007077)3.12218425
94muscle atrophy (GO:0014889)3.12180394
95tRNA aminoacylation for protein translation (GO:0006418)3.11844771
96ribosome assembly (GO:0042255)3.11562510
97regulation of actin filament-based movement (GO:1903115)3.09881049
98muscle tissue morphogenesis (GO:0060415)3.07570707
99nuclear pore organization (GO:0006999)3.03662478
100heterochromatin organization (GO:0070828)3.02842802
101regulation of receptor recycling (GO:0001919)3.02325347
102macromolecular complex disassembly (GO:0032984)3.01865436
103ribosome biogenesis (GO:0042254)3.01593738
104cardiac muscle tissue morphogenesis (GO:0055008)3.00980959
105syncytium formation by plasma membrane fusion (GO:0000768)3.00976471
106regulation of protein localization to cell surface (GO:2000008)3.00745772
107regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.00149375
108striated muscle adaptation (GO:0014888)3.00118149
109nuclear envelope disassembly (GO:0051081)2.99642292
110membrane disassembly (GO:0030397)2.99642292
111negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.98632953
112negative regulation of calcium ion transmembrane transport (GO:1903170)2.98632953
113desmosome organization (GO:0002934)2.95056485
114telomere maintenance via telomere lengthening (GO:0010833)2.93793174
115regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.93767859
116mitotic recombination (GO:0006312)2.92204734
117regulation of protein heterodimerization activity (GO:0043497)2.91971665
118fructose metabolic process (GO:0006000)2.91582374
119nuclear pore complex assembly (GO:0051292)2.91060113
120positive regulation of myoblast differentiation (GO:0045663)2.90219426
121rRNA processing (GO:0006364)2.90129437
122spliceosomal snRNP assembly (GO:0000387)2.88176600
123extracellular fibril organization (GO:0043206)2.84105385
124regulation of the force of heart contraction (GO:0002026)2.83969181
125nucleotide-excision repair, DNA gap filling (GO:0006297)2.83933893
126tricarboxylic acid cycle (GO:0006099)2.83041376
127cardiac muscle hypertrophy (GO:0003300)2.82904207
128somatic hypermutation of immunoglobulin genes (GO:0016446)2.82316979
129somatic diversification of immune receptors via somatic mutation (GO:0002566)2.82316979
130positive regulation of receptor recycling (GO:0001921)2.81620784
131nuclear-transcribed mRNA catabolic process (GO:0000956)2.80983340
132bundle of His cell to Purkinje myocyte communication (GO:0086069)2.80494769
133purine nucleobase biosynthetic process (GO:0009113)2.80370151
134fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.79658835
135rRNA metabolic process (GO:0016072)2.77471563
136positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.76158086
137regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.75463429
138establishment of integrated proviral latency (GO:0075713)2.75192579
139glycogen metabolic process (GO:0005977)2.73776306
140regulation of translational termination (GO:0006449)2.73766651
141DNA replication-dependent nucleosome organization (GO:0034723)2.73526543
142DNA replication-dependent nucleosome assembly (GO:0006335)2.73526543
143striated muscle hypertrophy (GO:0014897)2.73412840
144negative regulation of muscle contraction (GO:0045932)2.70412928
145establishment of protein localization to mitochondrial membrane (GO:0090151)2.69743846
146mRNA catabolic process (GO:0006402)2.68717080
147regulation of calcium ion transmembrane transport (GO:1903169)2.67768952
148regulation of calcium ion transmembrane transporter activity (GO:1901019)2.67768952
149cellular glucan metabolic process (GO:0006073)2.66947205
150glucan metabolic process (GO:0044042)2.66947205
151response to activity (GO:0014823)2.65147426
152striated muscle cell development (GO:0055002)2.64081471
153protein localization to kinetochore (GO:0034501)2.64059427
154protein targeting to membrane (GO:0006612)2.63894299
155gluconeogenesis (GO:0006094)2.63132973
156RNA catabolic process (GO:0006401)2.62057746
157regulation of integrin activation (GO:0033623)2.61562634
158histone arginine methylation (GO:0034969)2.61439179
159pseudouridine synthesis (GO:0001522)2.61243022
160muscle adaptation (GO:0043500)2.60968456
161negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.60851930
162regulation of mitotic spindle organization (GO:0060236)2.57727229
163regulation of muscle contraction (GO:0006937)2.54760335
164relaxation of muscle (GO:0090075)2.54309622
165cell-substrate junction assembly (GO:0007044)2.53959753
166DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.53783082
167nucleobase-containing small molecule interconversion (GO:0015949)2.53677708
168peptidyl-arginine omega-N-methylation (GO:0035247)2.53560531
169regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.52465052
170cellular component biogenesis (GO:0044085)2.51930752
171G1/S transition of mitotic cell cycle (GO:0000082)2.51632165
172cell cycle G1/S phase transition (GO:0044843)2.51632165
173establishment or maintenance of monopolar cell polarity (GO:0061339)2.51502670
174establishment of monopolar cell polarity (GO:0061162)2.51502670
175fibril organization (GO:0097435)2.50884077
176intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.49591841
177signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.49591841
178DNA replication checkpoint (GO:0000076)2.49297516
179regulation of muscle system process (GO:0090257)2.49161320
180muscle organ development (GO:0007517)2.48864143
181pore complex assembly (GO:0046931)2.48777385
182epithelial cell-cell adhesion (GO:0090136)2.48560243
183negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.48432840
184chromatin remodeling at centromere (GO:0031055)2.48273300
185signal transduction involved in DNA integrity checkpoint (GO:0072401)2.48141649
186signal transduction involved in DNA damage checkpoint (GO:0072422)2.48141649
187mitotic G1 DNA damage checkpoint (GO:0031571)2.47566717
188muscle hypertrophy (GO:0014896)2.47060451
189signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.46302565
190signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.46302565
191signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.46302565
192regulation of translational elongation (GO:0006448)2.46054068
193embryonic process involved in female pregnancy (GO:0060136)2.45944439
194muscle structure development (GO:0061061)2.45885700
195DNA geometric change (GO:0032392)2.45573708
196negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.44969868
197negative regulation of ligase activity (GO:0051352)2.44969868
198barbed-end actin filament capping (GO:0051016)2.43909112
199regulation of water loss via skin (GO:0033561)2.43637211

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.05355036
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.28375849
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.64458426
4MYC_19079543_ChIP-ChIP_MESCs_Mouse3.07454369
5* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.70065988
6BP1_19119308_ChIP-ChIP_Hs578T_Human2.69145176
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.66069408
8MYC_18358816_ChIP-ChIP_MESCs_Mouse2.62794469
9ESR1_20079471_ChIP-ChIP_T-47D_Human2.60723912
10TRIM28_21343339_ChIP-Seq_HEK293_Human2.56668121
11FOXM1_23109430_ChIP-Seq_U2OS_Human2.55902795
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.55595967
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.54629008
14ESR2_21235772_ChIP-Seq_MCF-7_Human2.53404836
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.46724252
16* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.37704941
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.37140348
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.36045705
19KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.35725381
20TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.28225756
21GABP_17652178_ChIP-ChIP_JURKAT_Human2.26687200
22CREB1_15753290_ChIP-ChIP_HEK293T_Human2.25939279
23FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.18298258
24THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.15500057
25POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.15297260
26XRN2_22483619_ChIP-Seq_HELA_Human2.14650663
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.13010232
28ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.10937642
29TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.10103704
30* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.07147607
31TBX20_22080862_ChIP-Seq_HEART_Mouse2.06549083
32TBX20_22328084_ChIP-Seq_HEART_Mouse2.06549083
33SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.06360937
34EGR1_19374776_ChIP-ChIP_THP-1_Human2.00813955
35STAT3_1855785_ChIP-Seq_MESCs_Mouse1.98058134
36HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.94040237
37NANOG_18555785_ChIP-Seq_MESCs_Mouse1.90258682
38CLOCK_20551151_ChIP-Seq_293T_Human1.90025765
39* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.86155636
40NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.85172936
41KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.84933266
42KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.84933266
43KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.84933266
44RXR_22158963_ChIP-Seq_LIVER_Mouse1.83551761
45DCP1A_22483619_ChIP-Seq_HELA_Human1.80994680
46ESR1_21235772_ChIP-Seq_MCF-7_Human1.80962579
47POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.80252348
48NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.79984268
49TTF2_22483619_ChIP-Seq_HELA_Human1.79288789
50VDR_23849224_ChIP-Seq_CD4+_Human1.76564468
51TFEB_21752829_ChIP-Seq_HELA_Human1.71782102
52* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.71658507
53* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.71117396
54MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.69501442
55LXR_22292898_ChIP-Seq_THP-1_Human1.67112556
56* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.66442260
57Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.60835364
58TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.60577412
59MYCN_18555785_ChIP-Seq_MESCs_Mouse1.60204530
60THAP11_20581084_ChIP-Seq_MESCs_Mouse1.60161177
61GATA2_21666600_ChIP-Seq_HMVEC_Human1.58656324
62CDX2_19796622_ChIP-Seq_MESCs_Mouse1.57486992
63* RACK7_27058665_Chip-Seq_MCF-7_Human1.56889476
64GATA1_19941827_ChIP-Seq_MEL_Mouse1.54863934
65* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.54756799
66GABP_19822575_ChIP-Seq_HepG2_Human1.54523552
67PPARA_22158963_ChIP-Seq_LIVER_Mouse1.53417004
68PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.52506032
69FOXP3_21729870_ChIP-Seq_TREG_Human1.51276335
70E2F1_21310950_ChIP-Seq_MCF-7_Human1.50412663
71ZFX_18555785_ChIP-Seq_MESCs_Mouse1.48592877
72ELK1_19687146_ChIP-ChIP_HELA_Human1.47361487
73* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.46511685
74MYC_22102868_ChIP-Seq_BL_Human1.46033816
75* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.45937193
76TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.44857912
77RBPJ_22232070_ChIP-Seq_NCS_Mouse1.42654128
78SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.42491561
79GATA1_19941826_ChIP-Seq_K562_Human1.42367220
80TP63_17297297_ChIP-ChIP_HaCaT_Human1.41736131
81POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.40869584
82TCF3_18692474_ChIP-Seq_MEFs_Mouse1.39535415
83SOX9_24532713_ChIP-Seq_HFSC_Mouse1.36351454
84SRY_22984422_ChIP-ChIP_TESTIS_Rat1.36285792
85DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.35475785
86CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.35275972
87SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.34939116
88PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34025758
89YY1_21170310_ChIP-Seq_MESCs_Mouse1.33202613
90TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32383142
91VDR_21846776_ChIP-Seq_THP-1_Human1.30813094
92* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.30697146
93CIITA_25753668_ChIP-Seq_RAJI_Human1.30238731
94HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.30234503
95MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.30168452
96ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.30141797
97* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.30077644
98RARG_19884340_ChIP-ChIP_MEFs_Mouse1.28723557
99HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.28507666
100SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.27710700
101SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.27710700
102KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.27374671
103* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.25521143
104CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.24304821
105NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.23945729
106KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.23854763
107ZNF263_19887448_ChIP-Seq_K562_Human1.23680575
108FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.23353794
109SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.23227325
110* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.23200206
111* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.23171036
112PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.22283309
113* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.22275186
114SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.21944710
115HOXB4_20404135_ChIP-ChIP_EML_Mouse1.21808290
116PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.20926074
117EP300_21415370_ChIP-Seq_HL-1_Mouse1.20815070
118LXR_22158963_ChIP-Seq_LIVER_Mouse1.20729822
119PPAR_26484153_Chip-Seq_NCI-H1993_Human1.20500023
120AR_21909140_ChIP-Seq_LNCAP_Human1.20145382
121* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.19770215
122* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.19379073
123HIF1A_21447827_ChIP-Seq_MCF-7_Human1.19232161
124GATA2_19941826_ChIP-Seq_K562_Human1.18964255
125ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.18330431
126BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.17698631
127ATF3_27146783_Chip-Seq_COLON_Human1.17514276
128SRF_21415370_ChIP-Seq_HL-1_Mouse1.17246851
129YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16626223
130SOX2_20726797_ChIP-Seq_SW620_Human1.16389594
131SPI1_23127762_ChIP-Seq_K562_Human1.15774528
132NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.15435159
133FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.15236085
134NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.14486414
135KDM5A_27292631_Chip-Seq_BREAST_Human1.14405463
136TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.13910595
137FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.13776056
138* TP63_22573176_ChIP-Seq_HFKS_Human1.12874367
139SOX2_18555785_ChIP-Seq_MESCs_Mouse1.12601708
140SOX2_18692474_ChIP-Seq_MEFs_Mouse1.11235181
141GATA4_21415370_ChIP-Seq_HL-1_Mouse1.10813857
142GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.09710987
143OCT4_18692474_ChIP-Seq_MEFs_Mouse1.09672529
144RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09448417
145GATA1_22383799_ChIP-Seq_G1ME_Mouse1.09210868
146STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.08690488
147* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.08630618
148ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.08127460
149* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.07071502
150ESR1_15608294_ChIP-ChIP_MCF-7_Human1.06440990
151ELF1_17652178_ChIP-ChIP_JURKAT_Human1.05736992
152* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.04930608
153RAD21_21589869_ChIP-Seq_MESCs_Mouse1.04830280
154NRF2_20460467_ChIP-Seq_MEFs_Mouse1.04114304
155NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.04114304
156PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.03940591
157NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.03121467
158ELK1_22589737_ChIP-Seq_MCF10A_Human1.03107167
159MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.02566587
160SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01922148
161SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.01698712
162NFIB_24661679_ChIP-Seq_LUNG_Mouse1.00491896
163* SA1_27219007_Chip-Seq_ERYTHROID_Human0.99835829
164MYB_21317192_ChIP-Seq_ERMYB_Mouse0.99751114
165* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.99714138
166ELK3_25401928_ChIP-Seq_HUVEC_Human0.99671978
167JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99136939
168NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.98514591
169RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.98248241
170TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.98169491
171* SPI1_23547873_ChIP-Seq_NB4_Human0.97749859
172SMC3_22415368_ChIP-Seq_MEFs_Mouse0.96211282
173SPI1_20517297_ChIP-Seq_HL60_Human0.95057664
174SMC1_22415368_ChIP-Seq_MEFs_Mouse0.93594719
175* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.93390514
176STAT1_20625510_ChIP-Seq_HELA_Human0.93206795
177CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.92564117
178P300_27058665_Chip-Seq_ZR-75-30cells_Human0.92488879
179SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.92183125
180BRD4_27068464_Chip-Seq_AML-cells_Mouse0.91407113
181* CTCF_27219007_Chip-Seq_Bcells_Human0.90741841
182RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.90120133
183PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89847470
184UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.88924992
185KDM2B_26808549_Chip-Seq_SUP-B15_Human0.88259901
186SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88028716

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue3.96174433
2MP0004036_abnormal_muscle_relaxation3.82981197
3MP0008438_abnormal_cutaneous_collagen3.69609382
4MP0003693_abnormal_embryo_hatching3.51965531
5MP0005451_abnormal_body_composition3.20889931
6MP0004957_abnormal_blastocyst_morpholog3.02102429
7MP0010352_gastrointestinal_tract_polyps2.98050288
8MP0003111_abnormal_nucleus_morphology2.61172078
9MP0003705_abnormal_hypodermis_morpholog2.61032096
10MP0002332_abnormal_exercise_endurance2.59383493
11MP0010094_abnormal_chromosome_stability2.50977049
12MP0005275_abnormal_skin_tensile2.34255645
13MP0003566_abnormal_cell_adhesion2.33300526
14MP0005620_abnormal_muscle_contractility2.33209200
15MP0003077_abnormal_cell_cycle2.24764320
16MP0002972_abnormal_cardiac_muscle2.22999483
17MP0005464_abnormal_platelet_physiology2.18730996
18MP0004510_myositis2.07951353
19MP0003279_aneurysm2.03905986
20MP0010307_abnormal_tumor_latency1.91404492
21MP0008057_abnormal_DNA_replication1.87360122
22MP0004130_abnormal_muscle_cell1.86930916
23MP0002837_dystrophic_cardiac_calcinosis1.86841659
24MP0008007_abnormal_cellular_replicative1.86290401
25MP0008932_abnormal_embryonic_tissue1.85272233
26MP0000750_abnormal_muscle_regeneration1.79162122
27MP0005623_abnormal_meninges_morphology1.77558083
28MP0002396_abnormal_hematopoietic_system1.77032088
29MP0000749_muscle_degeneration1.74244505
30MP0003191_abnormal_cellular_cholesterol1.74091240
31MP0008058_abnormal_DNA_repair1.70501415
32MP0001730_embryonic_growth_arrest1.70431901
33MP0000350_abnormal_cell_proliferation1.70052827
34MP0006036_abnormal_mitochondrial_physio1.65077973
35MP0004215_abnormal_myocardial_fiber1.63848977
36MP0005023_abnormal_wound_healing1.62383074
37MP0005503_abnormal_tendon_morphology1.57758338
38MP0009840_abnormal_foam_cell1.56818105
39MP0000751_myopathy1.54474536
40MP0003806_abnormal_nucleotide_metabolis1.53930453
41MP0003941_abnormal_skin_development1.53513625
42MP0004484_altered_response_of1.53038408
43MP0006138_congestive_heart_failure1.49351899
44MP0005076_abnormal_cell_differentiation1.47433810
45MP0000747_muscle_weakness1.45784518
46MP0004233_abnormal_muscle_weight1.45705442
47MP0002108_abnormal_muscle_morphology1.41303292
48MP0000490_abnormal_crypts_of1.40855012
49MP0004133_heterotaxia1.40280515
50MP0003786_premature_aging1.37976369
51MP0009780_abnormal_chondrocyte_physiolo1.37729758
52MP0000579_abnormal_nail_morphology1.37487765
53MP0001544_abnormal_cardiovascular_syste1.36455117
54MP0005385_cardiovascular_system_phenoty1.36455117
55MP0000858_altered_metastatic_potential1.36087753
56MP0009278_abnormal_bone_marrow1.33439435
57MP0008004_abnormal_stomach_pH1.33424896
58MP0002269_muscular_atrophy1.32202066
59MP0010030_abnormal_orbit_morphology1.32132374
60MP0005165_increased_susceptibility_to1.30361765
61MP0000759_abnormal_skeletal_muscle1.29418941
62MP0001697_abnormal_embryo_size1.28590996
63MP0008775_abnormal_heart_ventricle1.25675492
64MP0002060_abnormal_skin_morphology1.25522857
65MP0002080_prenatal_lethality1.25037643
66MP0001958_emphysema1.24407874
67MP0003567_abnormal_fetal_cardiomyocyte1.23898465
68MP0004197_abnormal_fetal_growth/weight/1.22968403
69MP0005083_abnormal_biliary_tract1.22927105
70MP0001672_abnormal_embryogenesis/_devel1.21158103
71MP0005380_embryogenesis_phenotype1.21158103
72MP0000733_abnormal_muscle_development1.20528743
73MP0002086_abnormal_extraembryonic_tissu1.18507888
74MP0001542_abnormal_bone_strength1.18145656
75MP0004808_abnormal_hematopoietic_stem1.17550894
76MP0000013_abnormal_adipose_tissue1.16652005
77MP0008260_abnormal_autophagy1.15651413
78MP0005397_hematopoietic_system_phenotyp1.15386894
79MP0001545_abnormal_hematopoietic_system1.15386894
80MP0006054_spinal_hemorrhage1.14503675
81MP0002084_abnormal_developmental_patter1.13013426
82MP0003984_embryonic_growth_retardation1.12977927
83MP0004084_abnormal_cardiac_muscle1.12788372
84MP0002085_abnormal_embryonic_tissue1.12402789
85MP0002877_abnormal_melanocyte_morpholog1.11130953
86MP0002796_impaired_skin_barrier1.10861626
87MP0002088_abnormal_embryonic_growth/wei1.10607362
88MP0002106_abnormal_muscle_physiology1.10540830
89MP0004087_abnormal_muscle_fiber1.10193494
90MP0003453_abnormal_keratinocyte_physiol1.07738968
91MP0004272_abnormal_basement_membrane1.07286877
92MP0000358_abnormal_cell_content/1.06693548
93MP0001849_ear_inflammation1.05196093
94MP0003656_abnormal_erythrocyte_physiolo1.03348559
95MP0005058_abnormal_lysosome_morphology1.02949711
96MP0001661_extended_life_span1.02892851
97MP0000343_altered_response_to1.01132702
98MP0000313_abnormal_cell_death0.99652637
99MP0002971_abnormal_brown_adipose0.96530658
100MP0003172_abnormal_lysosome_physiology0.95714535
101MP0002019_abnormal_tumor_incidence0.95334071
102MP0002127_abnormal_cardiovascular_syste0.93337732
103MP0003950_abnormal_plasma_membrane0.91758071
104MP0005369_muscle_phenotype0.91124994
105MP0005257_abnormal_intraocular_pressure0.90165968
106MP0001727_abnormal_embryo_implantation0.89884088
107MP0001243_abnormal_dermal_layer0.89828297
108MP0001915_intracranial_hemorrhage0.89459949
109MP0009333_abnormal_splenocyte_physiolog0.89022027
110MP0005508_abnormal_skeleton_morphology0.88301082
111MP0004381_abnormal_hair_follicle0.87996263
112MP0010234_abnormal_vibrissa_follicle0.85821132
113MP0003448_altered_tumor_morphology0.85401672
114MP0003075_altered_response_to0.85306367
115MP0004270_analgesia0.82061352
116MP0005375_adipose_tissue_phenotype0.80906579
117MP0005621_abnormal_cell_physiology0.80887749
118MP0010630_abnormal_cardiac_muscle0.80715792
119MP0005330_cardiomyopathy0.80587654
120MP0000467_abnormal_esophagus_morphology0.80537101
121MP0003828_pulmonary_edema0.80146170
122MP0003011_delayed_dark_adaptation0.79998418
123MP0005266_abnormal_metabolism0.79830846
124MP0004145_abnormal_muscle_electrophysio0.79215409
125MP0003091_abnormal_cell_migration0.78632145
126MP0002111_abnormal_tail_morphology0.77266896
127MP0000003_abnormal_adipose_tissue0.76963503
128MP0001348_abnormal_lacrimal_gland0.76358753
129MP0005367_renal/urinary_system_phenotyp0.76244000
130MP0000516_abnormal_urinary_system0.76244000
131MP0005666_abnormal_adipose_tissue0.75880958
132MP0003436_decreased_susceptibility_to0.75452641
133MP0005501_abnormal_skin_physiology0.74848451
134MP0005384_cellular_phenotype0.74771838
135MP0004858_abnormal_nervous_system0.74543781
136MP0000762_abnormal_tongue_morphology0.73332539
137MP0003283_abnormal_digestive_organ0.73311737
138MP0003221_abnormal_cardiomyocyte_apopto0.73300119
139MP0001293_anophthalmia0.73203167
140MP0000465_gastrointestinal_hemorrhage0.72695505
141MP0005166_decreased_susceptibility_to0.71346673
142MP0008770_decreased_survivor_rate0.70916920
143MP0000372_irregular_coat_pigmentation0.70250281
144MP0001853_heart_inflammation0.70094145
145MP0005174_abnormal_tail_pigmentation0.69753166
146MP0000371_diluted_coat_color0.69208290
147MP0009379_abnormal_foot_pigmentation0.68648473
148MP0000249_abnormal_blood_vessel0.62972394
149MP0003137_abnormal_impulse_conducting0.61874074
150MP0003879_abnormal_hair_cell0.61828069
151MP0003045_fibrosis0.61332825
152MP0004085_abnormal_heartbeat0.60962543
153MP0005167_abnormal_blood-brain_barrier0.60519364
154MP0002132_abnormal_respiratory_system0.59463502
155MP0002896_abnormal_bone_mineralization0.58334577
156MP0004185_abnormal_adipocyte_glucose0.57451918
157MP0005670_abnormal_white_adipose0.54377894
158MP0005409_darkened_coat_color0.54131600
159MP0008874_decreased_physiological_sensi0.54053672
160MP0005584_abnormal_enzyme/coenzyme_acti0.53954073
161MP0000230_abnormal_systemic_arterial0.52817754
162MP0003638_abnormal_response/metabolism_0.51570877
163MP0005319_abnormal_enzyme/_coenzyme0.51178430
164MP0001216_abnormal_epidermal_layer0.50693054

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)6.40761067
2Muscle hypertrophy of the lower extremities (HP:0008968)4.77106432
3Calf muscle hypertrophy (HP:0008981)4.46931543
4Protrusio acetabuli (HP:0003179)4.44869982
5EMG: myopathic abnormalities (HP:0003458)4.40982437
6Distal arthrogryposis (HP:0005684)4.10186734
7Centrally nucleated skeletal muscle fibers (HP:0003687)4.06716457
8Asymmetric septal hypertrophy (HP:0001670)4.03566927
9Abnormality of the calf musculature (HP:0001430)3.99862304
10Neck muscle weakness (HP:0000467)3.95985816
11Abnormality of cells of the erythroid lineage (HP:0012130)3.74644591
12Premature rupture of membranes (HP:0001788)3.73750367
13Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.73074885
14Ulnar deviation of the wrist (HP:0003049)3.68389236
15Sudden death (HP:0001699)3.66148179
16Myoglobinuria (HP:0002913)3.64809248
17Muscle fiber inclusion bodies (HP:0100299)3.64750029
18Type 1 muscle fiber predominance (HP:0003803)3.59242058
19Nemaline bodies (HP:0003798)3.45611375
20Fatigable weakness (HP:0003473)3.39182520
21Abnormality of the neuromuscular junction (HP:0003398)3.39182520
22Increased variability in muscle fiber diameter (HP:0003557)3.30477110
23Abnormality of the left ventricular outflow tract (HP:0011103)3.21904749
24Subaortic stenosis (HP:0001682)3.21904749
25Abnormal number of erythroid precursors (HP:0012131)3.17355045
26Trismus (HP:0000211)3.15132665
27Weak cry (HP:0001612)3.14441234
28Increased connective tissue (HP:0009025)3.12607719
29Rimmed vacuoles (HP:0003805)3.10677432
30Reticulocytopenia (HP:0001896)3.10549197
31Abnormality of the calcaneus (HP:0008364)3.05655815
32Fetal akinesia sequence (HP:0001989)3.03833032
33Calcaneovalgus deformity (HP:0001848)3.02697462
34Gowers sign (HP:0003391)3.00145102
35Bundle branch block (HP:0011710)2.98350617
36Bulbar palsy (HP:0001283)2.96949042
37Abnormality of placental membranes (HP:0011409)2.96116060
38Amniotic constriction ring (HP:0009775)2.96116060
39Difficulty running (HP:0009046)2.95766150
40Ankle contracture (HP:0006466)2.90992442
41Muscle stiffness (HP:0003552)2.89614740
42Cervical subluxation (HP:0003308)2.86256811
43Distal lower limb muscle weakness (HP:0009053)2.85862222
44Difficulty climbing stairs (HP:0003551)2.83944135
45Vertebral compression fractures (HP:0002953)2.83737546
46Cerebral aneurysm (HP:0004944)2.77541207
47Selective tooth agenesis (HP:0001592)2.76275777
48Mildly elevated creatine phosphokinase (HP:0008180)2.75779588
49Ventricular tachycardia (HP:0004756)2.72657974
50Round ear (HP:0100830)2.71888015
51Generalized muscle weakness (HP:0003324)2.69059363
52EMG: neuropathic changes (HP:0003445)2.68565307
53Wrist flexion contracture (HP:0001239)2.66739264
54Type 2 muscle fiber atrophy (HP:0003554)2.64500171
55Deformed tarsal bones (HP:0008119)2.64287904
56Agnosia (HP:0010524)2.57130207
57Spinal rigidity (HP:0003306)2.56789004
58Myopathic facies (HP:0002058)2.55735778
59Genu recurvatum (HP:0002816)2.48129528
60Breech presentation (HP:0001623)2.47246753
61Limb-girdle muscle atrophy (HP:0003797)2.47136607
62Colon cancer (HP:0003003)2.34994902
63Dilated cardiomyopathy (HP:0001644)2.34531857
64Pallor (HP:0000980)2.33919936
65Easy fatigability (HP:0003388)2.33062737
66Lipoatrophy (HP:0100578)2.29878005
67Absent thumb (HP:0009777)2.26093177
68Fragile skin (HP:0001030)2.25206716
69Carpal bone hypoplasia (HP:0001498)2.23839125
70Testicular atrophy (HP:0000029)2.22212726
71Soft skin (HP:0000977)2.21496686
72Exercise-induced muscle cramps (HP:0003710)2.17042735
73Scapular winging (HP:0003691)2.15281717
74Aplasia of the musculature (HP:0100854)2.14600733
75Macrocytic anemia (HP:0001972)2.12350774
76Malignant hyperthermia (HP:0002047)2.11906390
77Congenital hip dislocation (HP:0001374)2.11472292
78Lower limb amyotrophy (HP:0007210)2.11391387
79Distal upper limb amyotrophy (HP:0007149)2.09242001
80Upper limb amyotrophy (HP:0009129)2.09242001
81Rough bone trabeculation (HP:0100670)2.08980220
82Aplastic anemia (HP:0001915)2.08903592
83Abnormality of skeletal muscle fiber size (HP:0012084)2.08745432
84Aplasia/hypoplasia of the humerus (HP:0006507)2.08660962
85Hand muscle atrophy (HP:0009130)2.07387259
86Ventricular arrhythmia (HP:0004308)2.07233520
87Abnormal atrioventricular conduction (HP:0005150)2.06287889
88Atrophic scars (HP:0001075)2.06097629
89Areflexia of lower limbs (HP:0002522)2.04996144
90Birth length less than 3rd percentile (HP:0003561)2.04747281
91Popliteal pterygium (HP:0009756)2.04275264
92Muscle fibrillation (HP:0010546)2.03857937
93Peritonitis (HP:0002586)2.03029808
94Respiratory insufficiency due to muscle weakness (HP:0002747)2.02995386
95Joint stiffness (HP:0001387)2.02555389
96Degeneration of anterior horn cells (HP:0002398)2.02072797
97Abnormality of the anterior horn cell (HP:0006802)2.02072797
98Slender build (HP:0001533)2.01296317
99Ependymoma (HP:0002888)2.01190789
100Spinal muscular atrophy (HP:0007269)2.00688117
101Breast hypoplasia (HP:0003187)1.99864249
102Slender long bone (HP:0003100)1.99445519
103Abnormal hemoglobin (HP:0011902)1.98943115
104Shallow orbits (HP:0000586)1.98855603
105Vertebral hypoplasia (HP:0008417)1.98700770
106Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.98700770
107Short humerus (HP:0005792)1.98636910
108Heart block (HP:0012722)1.98256380
109Paralysis (HP:0003470)1.97439804
110Right ventricular cardiomyopathy (HP:0011663)1.96332740
111Abnormality of dentin (HP:0010299)1.96123043
112Purpura (HP:0000979)1.95321912
113Abnormal finger flexion creases (HP:0006143)1.95199269
114Rib fusion (HP:0000902)1.94421836
115Abnormality of the foot musculature (HP:0001436)1.91130202
116Nonprogressive disorder (HP:0003680)1.91020458
117Hyporeflexia of lower limbs (HP:0002600)1.90377910
118Progressive muscle weakness (HP:0003323)1.90236378
119Foot dorsiflexor weakness (HP:0009027)1.89702238
120Thin ribs (HP:0000883)1.87847446
121Petechiae (HP:0000967)1.87328311
122Myotonia (HP:0002486)1.86286812
123Wormian bones (HP:0002645)1.85743530
124Increased neuronal autofluorescent lipopigment (HP:0002074)1.83616296
125Generalized amyotrophy (HP:0003700)1.82745363
126Increased density of long bones (HP:0006392)1.82660352
127Frequent falls (HP:0002359)1.82243098
128Pterygium (HP:0001059)1.82014158
129Fused cervical vertebrae (HP:0002949)1.81333251
130Hypoplasia of the pons (HP:0012110)1.80195142
131Beaking of vertebral bodies (HP:0004568)1.79354435
132Absent radius (HP:0003974)1.78464423
133Rhabdomyolysis (HP:0003201)1.78139256
134Muscle fiber splitting (HP:0003555)1.77343041
135Distal lower limb amyotrophy (HP:0008944)1.76199153
136Patellar aplasia (HP:0006443)1.75874323
137Menorrhagia (HP:0000132)1.75714791
138Increased cerebral lipofuscin (HP:0011813)1.74231243
139Stenosis of the external auditory canal (HP:0000402)1.73826667
140Waddling gait (HP:0002515)1.72900223
141Thrombocytosis (HP:0001894)1.72805498
142Prolonged bleeding time (HP:0003010)1.72701040
143Muscular dystrophy (HP:0003560)1.72542861
144Tongue fasciculations (HP:0001308)1.71639400
145Biconcave vertebral bodies (HP:0004586)1.71619094
146Abnormality of the acetabulum (HP:0003170)1.70901115
147Neoplasm of the pancreas (HP:0002894)1.70450873
148Muscle fiber atrophy (HP:0100295)1.70382563
149Missing ribs (HP:0000921)1.70088284
150Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.69590091
151Ventricular fibrillation (HP:0001663)1.69458368
152Absent phalangeal crease (HP:0006109)1.67884638
153Abnormality of the umbilical cord (HP:0010881)1.67554328
154Abnormality of the Achilles tendon (HP:0005109)1.66912682
155Ragged-red muscle fibers (HP:0003200)1.66072090
156Akinesia (HP:0002304)1.65574812
157Metaphyseal cupping (HP:0003021)1.65465146
158Hip contracture (HP:0003273)1.62807382
159Achilles tendon contracture (HP:0001771)1.62080350
160Axonal loss (HP:0003447)1.60960706
161Abnormality of glycolipid metabolism (HP:0010969)1.59229062
162Abnormality of liposaccharide metabolism (HP:0010968)1.59229062
163Abnormality of glycosphingolipid metabolism (HP:0004343)1.59229062
164Increased mean platelet volume (HP:0011877)1.54438515
165Exercise intolerance (HP:0003546)1.53765150
166Abnormal pupillary function (HP:0007686)1.50244439
167Hyperkalemia (HP:0002153)1.48273783
168Onycholysis (HP:0001806)1.47124003

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PHKG14.16263868
2PHKG24.16263868
3EPHA23.89048901
4NME23.29311638
5WEE12.97398325
6BUB12.80950485
7MUSK2.78081382
8TTN2.70665729
9PIM22.47177953
10MAPKAPK32.32424815
11NEK12.28671553
12RPS6KB22.21028801
13MYLK2.17992176
14PAK42.02693444
15EIF2AK12.00135773
16CDC71.97396373
17SCYL21.89233977
18CDK121.88962117
19LATS21.80148543
20MAPK121.69620336
21ARAF1.69144511
22TTK1.64632085
23TSSK61.64624024
24PKN21.62894987
25FLT31.59407871
26CDK71.57012048
27MAP2K31.55927367
28BCKDK1.49417791
29NEK21.48142015
30RPS6KA41.47558049
31ERN11.45635851
32EEF2K1.45362243
33EIF2AK31.43944988
34DDR21.40743837
35PLK11.29789931
36MAP3K31.28089655
37SIK11.26075764
38ZAK1.25831506
39ZAP701.25218575
40ACVR1B1.24487586
41MAP3K111.22002613
42LRRK21.20990347
43AURKA1.19773297
44TRPM71.19265595
45ATR1.18498350
46MAP3K81.13933162
47AURKB1.13879392
48OBSCN1.13679772
49TGFBR11.10957630
50RIPK11.09766830
51MAP3K121.09764501
52CHEK21.09116838
53TESK11.06381415
54EPHB11.05416197
55SRPK11.03650335
56MATK1.03004936
57CAMK2G1.02178447
58TRIB30.99224764
59MST40.98026938
60TLK10.97938773
61VRK10.96672706
62PIM10.93051279
63BRSK20.90647892
64PINK10.90185013
65TESK20.87764962
66DYRK30.86332315
67MTOR0.85361389
68CCNB10.84526487
69PASK0.83945498
70PAK10.82281733
71PTK2B0.82084557
72MAP3K60.80588145
73PLK30.79787340
74KDR0.78262606
75PIK3CG0.77556332
76CSNK2A20.77110936
77PDK20.76980498
78MAP3K70.76319217
79PLK40.75233574
80NEK90.75085749
81PAK20.74991249
82MAP2K10.74840430
83DMPK0.74651490
84MST1R0.74570519
85AKT20.73531279
86PDK40.71702128
87PDK30.71702128
88TAOK20.71034481
89STK38L0.71013547
90CDK60.70951264
91CDK80.69534767
92MAP3K10.69244655
93IRAK30.69169659
94LIMK10.68375832
95CHEK10.67647688
96MAP3K50.66969360
97PRKCI0.66947136
98LMTK20.66688264
99ABL20.66561249
100CSNK2A10.66176354
101TGFBR20.65144624
102ROCK10.63011957
103DAPK30.61947979
104MAP2K40.60669770
105PRKD10.60232731
106NME10.60140329
107BMX0.60030204
108STK100.59077176
109MOS0.57960960
110MAPK70.57434163
111KSR20.56183656
112RPS6KL10.56112163
113RPS6KC10.56112163
114MAP2K60.55587491
115RPS6KA60.55216868
116BLK0.54259652
117CAMK2D0.54168863
118ALK0.53515086
119DYRK1B0.53124698
120EPHB20.51789979
121PDGFRA0.51672243
122ATM0.51244189
123AKT30.51239219
124RPS6KA50.51194821
125CDK20.50706854
126ERBB30.50685502
127RIPK40.50222780
128ILK0.49646518
129YES10.49603583
130PDPK10.48742630
131MKNK10.48713382
132PRKAA20.46972230
133CDC42BPA0.46038234
134GRK70.45951403
135CDK40.45933280
136PRPF4B0.45545430
137BRD40.45531857
138FER0.45294727
139MAP3K20.44336163
140MAPKAPK20.44232794
141GRK60.43931827
142TAOK10.43733296
143MARK20.43120641
144PTK20.43113186
145MET0.42459688
146MAPK40.42427705
147DAPK10.41438901
148TBK10.41437603
149MAPK110.39279014
150IKBKB0.38667346
151MAP3K130.38054967
152PRKD20.37925987
153ROCK20.37007733
154BTK0.36114986
155MAPK150.36028251
156GRK50.35396802
157RPS6KA20.34226402
158CAMK2B0.33352591
159PKN10.32793051
160CSK0.31360972
161PRKG10.30482352
162ICK0.30295020
163PRKAA10.29451374

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.98738132
2DNA replication_Homo sapiens_hsa030303.83448566
3Mismatch repair_Homo sapiens_hsa034303.61341913
4Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.42087660
5Proteasome_Homo sapiens_hsa030503.25292401
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.89668930
7RNA polymerase_Homo sapiens_hsa030202.65380670
8RNA transport_Homo sapiens_hsa030132.57699929
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.48707688
10Base excision repair_Homo sapiens_hsa034102.44878517
11Nucleotide excision repair_Homo sapiens_hsa034202.41075747
12Spliceosome_Homo sapiens_hsa030402.40799432
13One carbon pool by folate_Homo sapiens_hsa006702.28410492
14Homologous recombination_Homo sapiens_hsa034402.17611012
15Fatty acid elongation_Homo sapiens_hsa000621.86688936
16Cell cycle_Homo sapiens_hsa041101.80578596
17p53 signaling pathway_Homo sapiens_hsa041151.70105609
18Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.67583830
19Pyrimidine metabolism_Homo sapiens_hsa002401.64793088
20Circadian rhythm_Homo sapiens_hsa047101.54937495
21Arginine and proline metabolism_Homo sapiens_hsa003301.53391471
22Fanconi anemia pathway_Homo sapiens_hsa034601.46212380
23Phenylalanine metabolism_Homo sapiens_hsa003601.45192758
24Insulin signaling pathway_Homo sapiens_hsa049101.40359286
25* Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.39169862
26Non-homologous end-joining_Homo sapiens_hsa034501.37172928
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.32008422
28Platelet activation_Homo sapiens_hsa046111.28648739
29RNA degradation_Homo sapiens_hsa030181.27151305
30Collecting duct acid secretion_Homo sapiens_hsa049661.25245824
31Starch and sucrose metabolism_Homo sapiens_hsa005001.24118961
32Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.24069964
33Sulfur metabolism_Homo sapiens_hsa009201.22685238
34Glucagon signaling pathway_Homo sapiens_hsa049221.20433468
35PPAR signaling pathway_Homo sapiens_hsa033201.16246230
36Epstein-Barr virus infection_Homo sapiens_hsa051691.15199791
37Fatty acid degradation_Homo sapiens_hsa000711.14995073
38Insulin resistance_Homo sapiens_hsa049311.12649993
39Adipocytokine signaling pathway_Homo sapiens_hsa049201.07057872
40mRNA surveillance pathway_Homo sapiens_hsa030151.04208515
41Bladder cancer_Homo sapiens_hsa052191.03422315
42Basal transcription factors_Homo sapiens_hsa030221.03237364
43Tyrosine metabolism_Homo sapiens_hsa003501.03028672
44Glutathione metabolism_Homo sapiens_hsa004800.98622844
45Legionellosis_Homo sapiens_hsa051340.98482749
46Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.98005844
47Viral carcinogenesis_Homo sapiens_hsa052030.97117461
48Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.96609752
49Parkinsons disease_Homo sapiens_hsa050120.95753716
50ECM-receptor interaction_Homo sapiens_hsa045120.93622889
51Other glycan degradation_Homo sapiens_hsa005110.92346907
52Pyruvate metabolism_Homo sapiens_hsa006200.92263071
53Huntingtons disease_Homo sapiens_hsa050160.91749070
54Oxidative phosphorylation_Homo sapiens_hsa001900.90499432
55Shigellosis_Homo sapiens_hsa051310.90294348
56Purine metabolism_Homo sapiens_hsa002300.89935291
57beta-Alanine metabolism_Homo sapiens_hsa004100.88514036
58Arginine biosynthesis_Homo sapiens_hsa002200.87503875
59Adherens junction_Homo sapiens_hsa045200.87336413
60Thyroid cancer_Homo sapiens_hsa052160.86420123
61Oxytocin signaling pathway_Homo sapiens_hsa049210.86306867
62Vascular smooth muscle contraction_Homo sapiens_hsa042700.85566162
63Calcium signaling pathway_Homo sapiens_hsa040200.84214782
64HIF-1 signaling pathway_Homo sapiens_hsa040660.83593800
65Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.83025946
66Protein export_Homo sapiens_hsa030600.82757033
67Apoptosis_Homo sapiens_hsa042100.82486248
682-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.82203093
69AMPK signaling pathway_Homo sapiens_hsa041520.82194472
70Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.81387415
71Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.80400885
72cGMP-PKG signaling pathway_Homo sapiens_hsa040220.78799429
73Sphingolipid metabolism_Homo sapiens_hsa006000.76217623
74Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.75771406
75HTLV-I infection_Homo sapiens_hsa051660.75706191
76Small cell lung cancer_Homo sapiens_hsa052220.74939045
77Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.74802829
78Fatty acid metabolism_Homo sapiens_hsa012120.74274035
79Phagosome_Homo sapiens_hsa041450.73743584
80SNARE interactions in vesicular transport_Homo sapiens_hsa041300.72505540
81TGF-beta signaling pathway_Homo sapiens_hsa043500.71885634
82Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71784908
83Focal adhesion_Homo sapiens_hsa045100.71442050
84Systemic lupus erythematosus_Homo sapiens_hsa053220.70223571
85Biosynthesis of amino acids_Homo sapiens_hsa012300.68643672
86Antigen processing and presentation_Homo sapiens_hsa046120.65779324
87Endocytosis_Homo sapiens_hsa041440.65577467
88Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.65240769
89MicroRNAs in cancer_Homo sapiens_hsa052060.64213381
90Complement and coagulation cascades_Homo sapiens_hsa046100.64037076
91Central carbon metabolism in cancer_Homo sapiens_hsa052300.62951292
92Lysosome_Homo sapiens_hsa041420.61732516
93Hippo signaling pathway_Homo sapiens_hsa043900.61347992
94Fructose and mannose metabolism_Homo sapiens_hsa000510.60362673
95Tight junction_Homo sapiens_hsa045300.59936273
96Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.58703524
97PI3K-Akt signaling pathway_Homo sapiens_hsa041510.58092067
98Herpes simplex infection_Homo sapiens_hsa051680.57692347
99Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.57477915
100Alzheimers disease_Homo sapiens_hsa050100.57247917
101Primary bile acid biosynthesis_Homo sapiens_hsa001200.56811947
102Proteoglycans in cancer_Homo sapiens_hsa052050.55346032
103Malaria_Homo sapiens_hsa051440.55345283
104Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.55020558
105Renin secretion_Homo sapiens_hsa049240.54448861
106Chronic myeloid leukemia_Homo sapiens_hsa052200.54112791
107AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.54003890
108Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.53661317
109Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.53161044
110Oocyte meiosis_Homo sapiens_hsa041140.52642059
111Carbon metabolism_Homo sapiens_hsa012000.52359914
112Glycosaminoglycan degradation_Homo sapiens_hsa005310.51772497
113Pentose phosphate pathway_Homo sapiens_hsa000300.51731698
114Peroxisome_Homo sapiens_hsa041460.51639799
115Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51409683
116Viral myocarditis_Homo sapiens_hsa054160.50522437
117Amoebiasis_Homo sapiens_hsa051460.50232161
118Galactose metabolism_Homo sapiens_hsa000520.48800456
119Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48417305
120Histidine metabolism_Homo sapiens_hsa003400.48082160
121Leukocyte transendothelial migration_Homo sapiens_hsa046700.47604881
122Arachidonic acid metabolism_Homo sapiens_hsa005900.47270312
123Leishmaniasis_Homo sapiens_hsa051400.47159445
124GnRH signaling pathway_Homo sapiens_hsa049120.46581864
125Dilated cardiomyopathy_Homo sapiens_hsa054140.46267966
126mTOR signaling pathway_Homo sapiens_hsa041500.46070038
127Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45832374
128Melanoma_Homo sapiens_hsa052180.44230189
129Pathways in cancer_Homo sapiens_hsa052000.44080162
130Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.43834667
131Acute myeloid leukemia_Homo sapiens_hsa052210.43385423
132Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43323079
133Cardiac muscle contraction_Homo sapiens_hsa042600.43279581
134Tuberculosis_Homo sapiens_hsa051520.43138958
135Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43033081
136Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.42762132
137Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.42671884
138Prion diseases_Homo sapiens_hsa050200.41628913
139Salmonella infection_Homo sapiens_hsa051320.41443581
140Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.41040736
141VEGF signaling pathway_Homo sapiens_hsa043700.40323136
142Hepatitis B_Homo sapiens_hsa051610.39608587
143N-Glycan biosynthesis_Homo sapiens_hsa005100.37860372
144Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.37000056
145Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.36618491
146Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35270171
147Sulfur relay system_Homo sapiens_hsa041220.34391089
148Pertussis_Homo sapiens_hsa051330.33977026
149Propanoate metabolism_Homo sapiens_hsa006400.33865152
150Gastric acid secretion_Homo sapiens_hsa049710.32838939
151Notch signaling pathway_Homo sapiens_hsa043300.32636305
152Chemical carcinogenesis_Homo sapiens_hsa052040.32176564
153Cyanoamino acid metabolism_Homo sapiens_hsa004600.30662301
154Vibrio cholerae infection_Homo sapiens_hsa051100.29607644
155Ovarian steroidogenesis_Homo sapiens_hsa049130.29325499
156Renal cell carcinoma_Homo sapiens_hsa052110.27479256

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