CYB5R3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes cytochrome b5 reductase, which includes a membrane-bound form in somatic cells (anchored in the endoplasmic reticulum, mitochondrial and other membranes) and a soluble form in erythrocytes. The membrane-bound form exists mainly on the cytoplasmic side of the endoplasmic reticulum and functions in desaturation and elongation of fatty acids, in cholesterol biosynthesis, and in drug metabolism. The erythrocyte form is located in a soluble fraction of circulating erythrocytes and is involved in methemoglobin reduction. The membrane-bound form has both membrane-binding and catalytic domains, while the soluble form has only the catalytic domain. Alternate splicing results in multiple transcript variants. Mutations in this gene cause methemoglobinemias. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)7.43671396
2proline metabolic process (GO:0006560)5.92707923
3sulfur amino acid catabolic process (GO:0000098)5.23317082
4protein heterotrimerization (GO:0070208)5.03335257
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.94314275
6L-phenylalanine metabolic process (GO:0006558)4.94314275
7protein retention in ER lumen (GO:0006621)4.63900478
8L-phenylalanine catabolic process (GO:0006559)4.63641431
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.63641431
10maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.60786490
11extracellular fibril organization (GO:0043206)4.46665475
12regulation of cholesterol homeostasis (GO:2000188)4.29895571
13intestinal cholesterol absorption (GO:0030299)4.29577670
14glutamine family amino acid biosynthetic process (GO:0009084)4.22650337
15negative regulation of fatty acid biosynthetic process (GO:0045717)4.21324742
16barbed-end actin filament capping (GO:0051016)4.11206340
17basement membrane organization (GO:0071711)4.10495780
18embryonic process involved in female pregnancy (GO:0060136)4.05885330
19glyoxylate metabolic process (GO:0046487)4.00131641
20Golgi transport vesicle coating (GO:0048200)3.92133443
21COPI coating of Golgi vesicle (GO:0048205)3.92133443
22fibril organization (GO:0097435)3.90594936
23COPII vesicle coating (GO:0048208)3.88247434
24establishment of apical/basal cell polarity (GO:0035089)3.86215104
25adhesion of symbiont to host (GO:0044406)3.85122172
26triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.85089712
27negative regulation of fibrinolysis (GO:0051918)3.83605564
28aromatic amino acid family catabolic process (GO:0009074)3.82693295
29triglyceride homeostasis (GO:0070328)3.81455747
30acylglycerol homeostasis (GO:0055090)3.81455747
31negative regulation of smooth muscle cell migration (GO:0014912)3.80890030
32skin morphogenesis (GO:0043589)3.80357954
33protein carboxylation (GO:0018214)3.77329678
34peptidyl-glutamic acid carboxylation (GO:0017187)3.77329678
35cell migration involved in heart development (GO:0060973)3.75612857
36virion attachment to host cell (GO:0019062)3.74840739
37adhesion of symbiont to host cell (GO:0044650)3.74840739
38transcription from mitochondrial promoter (GO:0006390)3.74262699
39very-low-density lipoprotein particle assembly (GO:0034379)3.71494123
40type B pancreatic cell proliferation (GO:0044342)3.68261113
41endodermal cell differentiation (GO:0035987)3.64148374
42alpha-linolenic acid metabolic process (GO:0036109)3.58686910
43oxidative demethylation (GO:0070989)3.57811732
44collagen fibril organization (GO:0030199)3.56007751
45regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.53947635
46regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.49769913
47stress fiber assembly (GO:0043149)3.49528077
48cysteine metabolic process (GO:0006534)3.47376731
49regulation of fibrinolysis (GO:0051917)3.40197700
50alkaloid metabolic process (GO:0009820)3.38039158
51cholesterol efflux (GO:0033344)3.38016165
52plasma lipoprotein particle assembly (GO:0034377)3.37095849
53regulation of integrin activation (GO:0033623)3.36629862
544-hydroxyproline metabolic process (GO:0019471)3.36097779
55regulation of plasminogen activation (GO:0010755)3.34053105
56high-density lipoprotein particle remodeling (GO:0034375)3.32300867
57establishment of monopolar cell polarity (GO:0061162)3.31693806
58establishment or maintenance of monopolar cell polarity (GO:0061339)3.31693806
59regulation of integrin-mediated signaling pathway (GO:2001044)3.29711936
60regulation of extracellular matrix disassembly (GO:0010715)3.26965129
61positive regulation of endothelial cell apoptotic process (GO:2000353)3.26851159
62bile acid biosynthetic process (GO:0006699)3.25251053
63extracellular matrix assembly (GO:0085029)3.22714238
64kynurenine metabolic process (GO:0070189)3.18931751
65regulation of protein activation cascade (GO:2000257)3.18495718
66bile acid metabolic process (GO:0008206)3.18275552
67vascular endothelial growth factor signaling pathway (GO:0038084)3.11955054
68positive regulation of extracellular matrix organization (GO:1903055)3.11542592
69urea cycle (GO:0000050)3.10833828
70urea metabolic process (GO:0019627)3.10833828
71lipoprotein metabolic process (GO:0042157)3.10365469
72tryptophan catabolic process (GO:0006569)3.09854343
73indole-containing compound catabolic process (GO:0042436)3.09854343
74indolalkylamine catabolic process (GO:0046218)3.09854343
75regulation of early endosome to late endosome transport (GO:2000641)3.09009022
76cell-substrate junction assembly (GO:0007044)3.07711760
77protein-lipid complex assembly (GO:0065005)3.07641678
78tryptophan metabolic process (GO:0006568)3.07281829
79complement activation, alternative pathway (GO:0006957)3.06956544
80negative regulation of fatty acid metabolic process (GO:0045922)3.06502773
81phospholipid efflux (GO:0033700)3.05733057
82fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.05569158
83epoxygenase P450 pathway (GO:0019373)3.04700715
84serine family amino acid catabolic process (GO:0009071)3.04299652
85cellular response to ATP (GO:0071318)3.03224697
86positive regulation of receptor recycling (GO:0001921)3.03151346
87regulation of complement activation (GO:0030449)3.03129504
88regulation of protein homooligomerization (GO:0032462)3.02836950
89chondrocyte proliferation (GO:0035988)3.02742200
90regulation of cholesterol esterification (GO:0010872)3.02344810
91xenobiotic catabolic process (GO:0042178)3.01191866
92apoptotic cell clearance (GO:0043277)3.01189747
93response to nitrosative stress (GO:0051409)2.99150175
94triglyceride catabolic process (GO:0019433)2.98578305
95positive regulation of protein homooligomerization (GO:0032464)2.98341699
96reverse cholesterol transport (GO:0043691)2.98159508
97cellular glucuronidation (GO:0052695)2.95999683
98cellular zinc ion homeostasis (GO:0006882)2.95498146
99lysine catabolic process (GO:0006554)2.95424330
100lysine metabolic process (GO:0006553)2.95424330
101cytolysis (GO:0019835)2.93048957
102plasma lipoprotein particle clearance (GO:0034381)2.92100948
103nitrogen cycle metabolic process (GO:0071941)2.91606052
104tyrosine metabolic process (GO:0006570)2.91089610
105embryonic placenta development (GO:0001892)2.90244699
106homocysteine metabolic process (GO:0050667)2.90048905
107neutral lipid catabolic process (GO:0046461)2.89155580
108acylglycerol catabolic process (GO:0046464)2.89155580
109negative regulation of homotypic cell-cell adhesion (GO:0034111)2.88164546
110aromatic amino acid family metabolic process (GO:0009072)2.88045115
111amino-acid betaine metabolic process (GO:0006577)2.85252166
112intestinal absorption (GO:0050892)2.85078249
113platelet degranulation (GO:0002576)2.83482528
114cholesterol homeostasis (GO:0042632)2.83230439
115regulation of fatty acid biosynthetic process (GO:0042304)2.81176430
116positive regulation of fatty acid beta-oxidation (GO:0032000)2.81096273
117fatty acid beta-oxidation (GO:0006635)2.80988452
118protein maturation by protein folding (GO:0022417)2.80882327
119positive regulation of fatty acid biosynthetic process (GO:0045723)2.79028617
120sterol homeostasis (GO:0055092)2.78692791
121pinocytosis (GO:0006907)2.78185770
122angiogenesis involved in wound healing (GO:0060055)2.76230790
123negative regulation of fatty acid transport (GO:2000192)2.75268726
124low-density lipoprotein particle clearance (GO:0034383)2.73662233
125adherens junction assembly (GO:0034333)2.73510295
126positive regulation of blood vessel endothelial cell migration (GO:0043536)2.72421416
127endocardial cushion development (GO:0003197)2.72223253
128glucuronate metabolic process (GO:0019585)2.69747011
129uronic acid metabolic process (GO:0006063)2.69747011
130regulation of triglyceride catabolic process (GO:0010896)2.69623844
131sequestering of extracellular ligand from receptor (GO:0035581)2.69407862
132plasma lipoprotein particle remodeling (GO:0034369)2.69135882
133protein-lipid complex remodeling (GO:0034368)2.69135882
134macromolecular complex remodeling (GO:0034367)2.69135882
135negative regulation of sterol transport (GO:0032372)2.68744561
136negative regulation of cholesterol transport (GO:0032375)2.68744561
137hyaluronan catabolic process (GO:0030214)2.68614480
138endothelial cell morphogenesis (GO:0001886)2.66543021
139L-alpha-amino acid transmembrane transport (GO:1902475)2.65913967
140collagen metabolic process (GO:0032963)2.65899190
141kidney mesenchyme development (GO:0072074)2.65078318
142protein localization to endosome (GO:0036010)2.64902400
143benzene-containing compound metabolic process (GO:0042537)2.62757141
144fatty acid oxidation (GO:0019395)2.62623731
145peptidyl-proline hydroxylation (GO:0019511)2.62160118
146blood vessel maturation (GO:0001955)2.61871244
147fibrinolysis (GO:0042730)2.60686071
148heme transport (GO:0015886)2.60332205
149cellular amino acid catabolic process (GO:0009063)2.60294402
150protein targeting to plasma membrane (GO:0072661)2.59551163
151hemidesmosome assembly (GO:0031581)2.57751351
152extracellular matrix disassembly (GO:0022617)2.57581219
153vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.56671124
154UV protection (GO:0009650)2.55948737
155cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.52922533
156cell proliferation involved in metanephros development (GO:0072203)2.52540515
157focal adhesion assembly (GO:0048041)2.52292104
158cell-substrate adherens junction assembly (GO:0007045)2.52292104
159positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.49821765
160planar cell polarity pathway involved in neural tube closure (GO:0090179)2.49072772
161positive regulation of collagen biosynthetic process (GO:0032967)2.49066650
162multicellular organismal macromolecule metabolic process (GO:0044259)2.48705754
163tooth mineralization (GO:0034505)2.46374059
164collagen catabolic process (GO:0030574)2.45813768
165regulation of collagen metabolic process (GO:0010712)2.44374120
166cellular response to vitamin (GO:0071295)2.43062353
167keratan sulfate catabolic process (GO:0042340)2.42985362
168positive regulation of osteoblast proliferation (GO:0033690)2.42851444
169extracellular matrix organization (GO:0030198)2.41189615
170glomerular basement membrane development (GO:0032836)2.40873558
171protein hydroxylation (GO:0018126)2.40395496
172extracellular structure organization (GO:0043062)2.39947826
173epithelial cell-cell adhesion (GO:0090136)2.39160539
174regulation of metalloenzyme activity (GO:0048552)2.38434454
175actin filament depolymerization (GO:0030042)2.37399610
176regulation of apoptotic process involved in morphogenesis (GO:1902337)2.36886810
177venous blood vessel morphogenesis (GO:0048845)2.36836369
178atrioventricular valve morphogenesis (GO:0003181)2.35188218
179cell adhesion mediated by integrin (GO:0033627)2.34954679
180embryo implantation (GO:0007566)2.34895938
181multicellular organismal metabolic process (GO:0044236)2.34130496
182regulation of extracellular matrix organization (GO:1903053)2.34049963
183negative regulation of platelet activation (GO:0010544)2.33317653
184retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.33252371
185positive regulation of collagen metabolic process (GO:0010714)2.33206899
186positive regulation of triglyceride lipase activity (GO:0061365)2.32895756
187positive regulation of lipoprotein lipase activity (GO:0051006)2.32895756
188cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.32837423
189platelet aggregation (GO:0070527)2.29474593
190retina vasculature morphogenesis in camera-type eye (GO:0061299)2.28894045

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.71798709
2* RXR_22158963_ChIP-Seq_LIVER_Mouse4.86295324
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.23503799
4* LXR_22158963_ChIP-Seq_LIVER_Mouse3.62898024
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.53043565
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.28439406
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.01684424
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.74344276
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.72635192
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.71276450
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.57179854
12EGR1_23403033_ChIP-Seq_LIVER_Mouse2.47570790
13CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.10382795
14LXR_22292898_ChIP-Seq_THP-1_Human2.03913217
15* CLOCK_20551151_ChIP-Seq_293T_Human2.02444688
16NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.97391080
17TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.96866564
18ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.92582682
19TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.91995739
20KDM2B_26808549_Chip-Seq_SUP-B15_Human1.86306056
21KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.86069534
22KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.86069534
23KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.86069534
24STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.82317021
25NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.69341899
26WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.69279561
27STAT3_1855785_ChIP-Seq_MESCs_Mouse1.68522373
28POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.64966551
29SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.64333127
30ESR1_21235772_ChIP-Seq_MCF-7_Human1.62950147
31* RACK7_27058665_Chip-Seq_MCF-7_Human1.62946320
32KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.61744947
33NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.56710217
34SRY_22984422_ChIP-ChIP_TESTIS_Rat1.52336771
35TCF3_18692474_ChIP-Seq_MEFs_Mouse1.51208494
36* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.49948561
37ESR1_15608294_ChIP-ChIP_MCF-7_Human1.49092865
38KDM2B_26808549_Chip-Seq_K562_Human1.48649382
39ESR2_21235772_ChIP-Seq_MCF-7_Human1.46888972
40TP53_22127205_ChIP-Seq_IMR90_Human1.45841689
41SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.45756039
42THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.44627342
43SMC1_22415368_ChIP-Seq_MEFs_Mouse1.43994273
44EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43713740
45* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.43651825
46SOX2_27498859_Chip-Seq_STOMACH_Mouse1.42695235
47ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.42653842
48SMC3_22415368_ChIP-Seq_MEFs_Mouse1.38846468
49EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.38103325
50TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.37710081
51TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.36172041
52ZNF263_19887448_ChIP-Seq_K562_Human1.36006473
53GATA2_21666600_ChIP-Seq_HMVEC_Human1.35301107
54* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.34664356
55CTCF_27219007_Chip-Seq_ERYTHROID_Human1.33552305
56DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.33353025
57DNAJC2_21179169_ChIP-ChIP_NT2_Human1.32580715
58* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32010372
59RXRA_24833708_ChIP-Seq_LIVER_Mouse1.31970642
60* ELK3_25401928_ChIP-Seq_HUVEC_Human1.31569328
61* KDM2B_26808549_Chip-Seq_DND41_Human1.30961568
62POU5F1_16518401_ChIP-PET_MESCs_Mouse1.30250733
63SA1_27219007_Chip-Seq_ERYTHROID_Human1.29058115
64ATF3_27146783_Chip-Seq_COLON_Human1.27494157
65MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.27382066
66TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.26845194
67NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.23735463
68* TET1_21451524_ChIP-Seq_MESCs_Mouse1.23647542
69TCF3_18692474_ChIP-Seq_MESCs_Mouse1.23276272
70HIF1A_21447827_ChIP-Seq_MCF-7_Human1.23250617
71TBX20_22328084_ChIP-Seq_HEART_Mouse1.22846861
72TBX20_22080862_ChIP-Seq_HEART_Mouse1.22846861
73EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.22389113
74CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.22135880
75* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.21684451
76P68_20966046_ChIP-Seq_HELA_Human1.20659846
77RARB_24833708_ChIP-Seq_LIVER_Mouse1.20102442
78EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.19564661
79TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.18515044
80KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.18435677
81ERG_21242973_ChIP-ChIP_JURKAT_Human1.17769606
82KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.17468357
83RARA_24833708_ChIP-Seq_LIVER_Mouse1.16411202
84* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.15842052
85NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.14887830
86DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.14614901
87RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.14448668
88TP53_23651856_ChIP-Seq_MEFs_Mouse1.12087559
89P300_27058665_Chip-Seq_ZR-75-30cells_Human1.11535939
90STAT6_21828071_ChIP-Seq_BEAS2B_Human1.10947799
91SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.09706683
92TET1_21490601_ChIP-Seq_MESCs_Mouse1.09327637
93TCF7_22412390_ChIP-Seq_EML_Mouse1.09227927
94SMC4_20622854_ChIP-Seq_HELA_Human1.09206680
95ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.08898344
96VDR_21846776_ChIP-Seq_THP-1_Human1.08318936
97UBF1/2_26484160_Chip-Seq_HMECs_Human1.07900138
98* CTCF_27219007_Chip-Seq_Bcells_Human1.07680755
99CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.07240529
100ZFP281_18757296_ChIP-ChIP_E14_Mouse1.07089448
101SOX2_18692474_ChIP-Seq_MEFs_Mouse1.06758336
102CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.05456091
103CDX2_20551321_ChIP-Seq_CACO-2_Human1.05198763
104EED_16625203_ChIP-ChIP_MESCs_Mouse1.05078551
105* RAD21_21589869_ChIP-Seq_MESCs_Mouse1.03865255
106SOX9_24532713_ChIP-Seq_HFSC_Mouse1.03596033
107HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.03320147
108RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.02668996
109SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.02572209
110SA1_22415368_ChIP-Seq_MEFs_Mouse1.02240442
111ELF1_20517297_ChIP-Seq_JURKAT_Human1.01653780
112RNF2_18974828_ChIP-Seq_MESCs_Mouse1.01073696
113EZH2_18974828_ChIP-Seq_MESCs_Mouse1.01073696
114PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.00898268
115SALL4_18804426_ChIP-ChIP_XEN_Mouse1.00621381
116* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98457837
117UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.97897245
118KDM2B_26808549_Chip-Seq_JURKAT_Human0.97824255
119SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97160238
120OCT4_18692474_ChIP-Seq_MEFs_Mouse0.97075301
121NANOG_21062744_ChIP-ChIP_HESCs_Human0.96049024
122SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.95827034
123* TP63_22573176_ChIP-Seq_HFKS_Human0.95020480
124* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.94668947
125SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.94445903
126MTF2_20144788_ChIP-Seq_MESCs_Mouse0.94274640
127CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.93903532
128JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92593928
129E2F1_18555785_ChIP-Seq_MESCs_Mouse0.90117812
130P63_26484246_Chip-Seq_KERATINOCYTES_Human0.89042709
131* EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.88753238
132TFEB_21752829_ChIP-Seq_HELA_Human0.88692732
133KLF4_18555785_ChIP-Seq_MESCs_Mouse0.88357961
134SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.87846785
135* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.87488432
136SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87331664
137* GATA6_25053715_ChIP-Seq_YYC3_Human0.87062673
138ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.86735479
139TP53_20018659_ChIP-ChIP_R1E_Mouse0.86564787
140SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.86387942
141SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.85761614
142NFIB_24661679_ChIP-Seq_LUNG_Mouse0.85341920
143GATA4_25053715_ChIP-Seq_YYC3_Human0.83016147
144ETS1_21867929_ChIP-Seq_TH2_Mouse0.82750715
145BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.82215440
146HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.81475026
147CTCF_21964334_ChIP-Seq_BJAB-B_Human0.80981084

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.84813250
2MP0005365_abnormal_bile_salt4.28438811
3MP0005360_urolithiasis4.17982010
4MP0005085_abnormal_gallbladder_physiolo4.10014052
5MP0003705_abnormal_hypodermis_morpholog2.99889937
6MP0008875_abnormal_xenobiotic_pharmacok2.94642480
7MP0003806_abnormal_nucleotide_metabolis2.87364324
8MP0008438_abnormal_cutaneous_collagen2.68809619
9MP0003252_abnormal_bile_duct2.59525418
10MP0003283_abnormal_digestive_organ2.52595210
11MP0010030_abnormal_orbit_morphology2.42110795
12MP0009840_abnormal_foam_cell2.41322516
13MP0005623_abnormal_meninges_morphology2.37102331
14MP0002877_abnormal_melanocyte_morpholog2.28328261
15MP0000751_myopathy2.26230023
16MP0003195_calcinosis2.26211425
17MP0010329_abnormal_lipoprotein_level2.16671269
18MP0005083_abnormal_biliary_tract2.02450221
19MP0004858_abnormal_nervous_system1.97430146
20MP0000767_abnormal_smooth_muscle1.86630911
21MP0009278_abnormal_bone_marrow1.86266131
22MP0006054_spinal_hemorrhage1.85073077
23MP0001542_abnormal_bone_strength1.76581989
24MP0004019_abnormal_vitamin_homeostasis1.74916322
25MP0001666_abnormal_nutrient_absorption1.74073589
26MP0005332_abnormal_amino_acid1.68340331
27MP0005220_abnormal_exocrine_pancreas1.67535103
28MP0003091_abnormal_cell_migration1.65649264
29MP0009780_abnormal_chondrocyte_physiolo1.64127359
30MP0005275_abnormal_skin_tensile1.61907080
31MP0004233_abnormal_muscle_weight1.54668654
32MP0005375_adipose_tissue_phenotype1.53229311
33MP0002060_abnormal_skin_morphology1.50897205
34MP0005058_abnormal_lysosome_morphology1.49344959
35MP0000609_abnormal_liver_physiology1.47194086
36MP0009053_abnormal_anal_canal1.47174344
37MP0003566_abnormal_cell_adhesion1.43874166
38MP0000013_abnormal_adipose_tissue1.43221728
39MP0005666_abnormal_adipose_tissue1.40149496
40MP0010352_gastrointestinal_tract_polyps1.39238943
41MP0005023_abnormal_wound_healing1.36958969
42MP0003191_abnormal_cellular_cholesterol1.36058969
43MP0002118_abnormal_lipid_homeostasis1.35733912
44MP0006138_congestive_heart_failure1.34990969
45MP0003950_abnormal_plasma_membrane1.30577885
46MP0003279_aneurysm1.28266935
47MP0005464_abnormal_platelet_physiology1.28217889
48MP0005595_abnormal_vascular_smooth1.27981872
49MP0001849_ear_inflammation1.26124818
50MP0005319_abnormal_enzyme/_coenzyme1.25868955
51MP0004264_abnormal_extraembryonic_tissu1.23903290
52MP0003453_abnormal_keratinocyte_physiol1.20335369
53MP0000343_altered_response_to1.19825933
54MP0001879_abnormal_lymphatic_vessel1.19238221
55MP0000534_abnormal_ureter_morphology1.13243898
56MP0000678_abnormal_parathyroid_gland1.13139816
57MP0005171_absent_coat_pigmentation1.12671133
58MP0005503_abnormal_tendon_morphology1.12282597
59MP0009643_abnormal_urine_homeostasis1.11386009
60MP0005409_darkened_coat_color1.11150257
61MP0005390_skeleton_phenotype1.11051004
62MP0003119_abnormal_digestive_system1.11000358
63MP0000639_abnormal_adrenal_gland1.10472903
64MP0005508_abnormal_skeleton_morphology1.08193309
65MP0005076_abnormal_cell_differentiation1.07686075
66MP0003329_amyloid_beta_deposits1.07642767
67MP0003186_abnormal_redox_activity1.07324612
68MP0003890_abnormal_embryonic-extraembry1.06675445
69MP0002138_abnormal_hepatobiliary_system1.06253604
70MP0002249_abnormal_larynx_morphology1.05714090
71MP0002933_joint_inflammation1.04567889
72MP0010368_abnormal_lymphatic_system1.04180150
73MP0000858_altered_metastatic_potential1.03935206
74MP0004510_myositis1.03625804
75MP0005164_abnormal_response_to1.02712964
76MP0000598_abnormal_liver_morphology1.00339632
77MP0000462_abnormal_digestive_system0.99888353
78MP0001944_abnormal_pancreas_morphology0.99742066
79MP0005165_increased_susceptibility_to0.99352581
80MP0004130_abnormal_muscle_cell0.98871227
81MP0000759_abnormal_skeletal_muscle0.98181754
82MP0003172_abnormal_lysosome_physiology0.98032224
83MP0002168_other_aberrant_phenotype0.96482323
84MP0002653_abnormal_ependyma_morphology0.95966163
85MP0004272_abnormal_basement_membrane0.95892768
86MP0002282_abnormal_trachea_morphology0.94044281
87MP0000249_abnormal_blood_vessel0.93236727
88MP0002269_muscular_atrophy0.92421223
89MP0002896_abnormal_bone_mineralization0.92421183
90MP0002295_abnormal_pulmonary_circulatio0.92096911
91MP0002796_impaired_skin_barrier0.90527306
92MP0000003_abnormal_adipose_tissue0.90357541
93MP0003828_pulmonary_edema0.88912677
94MP0000579_abnormal_nail_morphology0.88416398
95MP0002128_abnormal_blood_circulation0.87234039
96MP0003075_altered_response_to0.87160023
97MP0001533_abnormal_skeleton_physiology0.86942171
98MP0004133_heterotaxia0.86388883
99MP0002089_abnormal_postnatal_growth/wei0.86121235
100MP0002078_abnormal_glucose_homeostasis0.85628428
101MP0003300_gastrointestinal_ulcer0.84126078
102MP0005330_cardiomyopathy0.84088779
103MP0001614_abnormal_blood_vessel0.82389784
104MP0002998_abnormal_bone_remodeling0.81890918
105MP0005397_hematopoietic_system_phenotyp0.79239532
106MP0001545_abnormal_hematopoietic_system0.79239532
107MP0001915_intracranial_hemorrhage0.79051232
108MP0005248_abnormal_Harderian_gland0.77385783
109MP0009250_abnormal_appendicular_skeleto0.77166489
110MP0001756_abnormal_urination0.76795125
111MP0000749_muscle_degeneration0.75932672
112MP0003656_abnormal_erythrocyte_physiolo0.75556727
113MP0004087_abnormal_muscle_fiber0.75529755
114MP0004185_abnormal_adipocyte_glucose0.75176882
115MP0001299_abnormal_eye_distance/0.74303643
116MP0008260_abnormal_autophagy0.73569543
117MP0002009_preneoplasia0.73273847
118MP0005670_abnormal_white_adipose0.73221982
119MP0000733_abnormal_muscle_development0.72306151
120MP0002837_dystrophic_cardiac_calcinosis0.72302225
121MP0005451_abnormal_body_composition0.72194564
122MP0001764_abnormal_homeostasis0.72181493
123MP0000750_abnormal_muscle_regeneration0.72061937
124MP0004084_abnormal_cardiac_muscle0.71131900
125MP0003959_abnormal_lean_body0.70940023
126MP0005257_abnormal_intraocular_pressure0.70801309
127MP0002113_abnormal_skeleton_development0.69093149
128MP0003045_fibrosis0.68708035
129MP0000604_amyloidosis0.68131821
130MP0009384_cardiac_valve_regurgitation0.67801614
131MP0000163_abnormal_cartilage_morphology0.67503184
132MP0008004_abnormal_stomach_pH0.67303361
133MP0003942_abnormal_urinary_system0.67234799
134MP0002928_abnormal_bile_duct0.67042701
135MP0002970_abnormal_white_adipose0.66975650
136MP0009115_abnormal_fat_cell0.66666098
137MP0005395_other_phenotype0.66605796
138MP0000371_diluted_coat_color0.66351911
139MP0000681_abnormal_thyroid_gland0.66305597
140MP0002111_abnormal_tail_morphology0.66003204
141MP0000762_abnormal_tongue_morphology0.65302760
142MP0002971_abnormal_brown_adipose0.65215784
143MP0001958_emphysema0.64452536
144MP0002254_reproductive_system_inflammat0.64291934
145MP0008995_early_reproductive_senescence0.63696867
146MP0004197_abnormal_fetal_growth/weight/0.63685173
147MP0002086_abnormal_extraembryonic_tissu0.63600839
148MP0002932_abnormal_joint_morphology0.61521066
149MP0004883_abnormal_blood_vessel0.61343927
150MP0003795_abnormal_bone_structure0.61155355
151MP0001340_abnormal_eyelid_morphology0.60979491
152MP0005266_abnormal_metabolism0.60897428
153MP0008057_abnormal_DNA_replication0.60815393
154MP0001243_abnormal_dermal_layer0.60228368
155MP0005376_homeostasis/metabolism_phenot0.59725835
156MP0002108_abnormal_muscle_morphology0.58191147
157MP0000467_abnormal_esophagus_morphology0.56676481

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.02763911
2Intrahepatic cholestasis (HP:0001406)4.27443448
3Turricephaly (HP:0000262)4.22040568
4Abnormality of monocarboxylic acid metabolism (HP:0010996)4.19489992
5Hypoglycemic coma (HP:0001325)4.19486112
6Aortic aneurysm (HP:0004942)4.17939459
7Deep venous thrombosis (HP:0002625)4.15164169
8Hypobetalipoproteinemia (HP:0003563)4.05758924
9Xanthomatosis (HP:0000991)4.03599245
10Ankle contracture (HP:0006466)3.90465356
11Aortic dissection (HP:0002647)3.82725168
12Mucopolysacchariduria (HP:0008155)3.78310368
13Urinary glycosaminoglycan excretion (HP:0003541)3.78310368
14Vascular tortuosity (HP:0004948)3.69681152
15Alopecia of scalp (HP:0002293)3.64769494
16Spinal rigidity (HP:0003306)3.61967048
17Ketoacidosis (HP:0001993)3.51318674
18Bladder diverticulum (HP:0000015)3.47888117
19Protrusio acetabuli (HP:0003179)3.47811815
20Abnormality of polysaccharide metabolism (HP:0011012)3.43858923
21Abnormality of glycosaminoglycan metabolism (HP:0004371)3.43858923
22Abnormality of mucopolysaccharide metabolism (HP:0011020)3.43858923
23Type 1 muscle fiber predominance (HP:0003803)3.39900592
24Hypoglycemic seizures (HP:0002173)3.39221249
25Increased variability in muscle fiber diameter (HP:0003557)3.35737099
26Soft skin (HP:0000977)3.29429207
27Wormian bones (HP:0002645)3.25498983
28Dysostosis multiplex (HP:0000943)3.24566201
29Ketosis (HP:0001946)3.21123672
30Follicular hyperkeratosis (HP:0007502)3.18000786
31Shallow orbits (HP:0000586)3.16929436
32Atrophic scars (HP:0001075)3.14363886
33Arterial tortuosity (HP:0005116)3.10050705
34Fragile skin (HP:0001030)3.09694486
35Hypolipoproteinemia (HP:0010981)3.07877374
36Prolonged partial thromboplastin time (HP:0003645)3.02232449
37Hyperinsulinemic hypoglycemia (HP:0000825)3.01687960
38Abnormality of dentin (HP:0010299)3.00776093
39Broad metatarsal (HP:0001783)2.94279550
40Pancreatic islet-cell hyperplasia (HP:0004510)2.89933725
41Abnormality of skeletal muscle fiber size (HP:0012084)2.89328311
42Myocardial infarction (HP:0001658)2.86020083
43Slender build (HP:0001533)2.85575911
44Ulnar bowing (HP:0003031)2.84929836
45Premature rupture of membranes (HP:0001788)2.83784387
46Cerebral aneurysm (HP:0004944)2.82641974
47Abnormality of glutamine family amino acid metabolism (HP:0010902)2.78450128
48Biconcave vertebral bodies (HP:0004586)2.77735343
49Abnormality of the intrinsic pathway (HP:0010989)2.77481594
50Increased connective tissue (HP:0009025)2.77013821
51Complement deficiency (HP:0004431)2.76397411
52Hypochromic microcytic anemia (HP:0004840)2.75558781
53Neonatal short-limb short stature (HP:0008921)2.74388002
54Fat malabsorption (HP:0002630)2.72767109
55Abnormality of the common coagulation pathway (HP:0010990)2.72486072
56Dilatation of the ascending aorta (HP:0005111)2.71266559
57Coronal craniosynostosis (HP:0004440)2.68452045
58Mildly elevated creatine phosphokinase (HP:0008180)2.67241064
59Late onset (HP:0003584)2.66263355
60Growth hormone excess (HP:0000845)2.65512806
61Abnormality of endocrine pancreas physiology (HP:0012093)2.64585176
62Abnormality of the pancreatic islet cells (HP:0006476)2.64585176
63Hyperammonemia (HP:0001987)2.62193549
64Hypoalphalipoproteinemia (HP:0003233)2.57929280
65Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.57888622
66Hyperglycemia (HP:0003074)2.57538885
67Menorrhagia (HP:0000132)2.56869725
68Symptomatic seizures (HP:0011145)2.56150865
69Mitral regurgitation (HP:0001653)2.55188021
70Rib fusion (HP:0000902)2.52016520
71Epidermoid cyst (HP:0200040)2.48233356
72Genu recurvatum (HP:0002816)2.46812236
73Abnormality of the Achilles tendon (HP:0005109)2.45615895
74Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.44922894
75Vertebral hypoplasia (HP:0008417)2.44922894
76Achilles tendon contracture (HP:0001771)2.42862495
77Upper limb amyotrophy (HP:0009129)2.42160010
78Distal upper limb amyotrophy (HP:0007149)2.42160010
79Abnormality of complement system (HP:0005339)2.42148959
80Purpura (HP:0000979)2.41300895
81Large for gestational age (HP:0001520)2.40999785
82Pustule (HP:0200039)2.38951515
83Elbow flexion contracture (HP:0002987)2.38942287
84Hyperlipoproteinemia (HP:0010980)2.37296363
85Joint laxity (HP:0001388)2.33356703
86Mitral stenosis (HP:0001718)2.32635303
87Dysautonomia (HP:0002459)2.28968112
88Distal lower limb amyotrophy (HP:0008944)2.28873783
89Abnormal delivery (HP:0001787)2.27207017
90Hemorrhage of the eye (HP:0011885)2.26364076
91Abnormality of the acetabulum (HP:0003170)2.26026392
92Hyperextensible skin (HP:0000974)2.25629368
93Generalized amyotrophy (HP:0003700)2.24859883
94Abnormality of sulfur amino acid metabolism (HP:0004339)2.23446440
95Increased mean platelet volume (HP:0011877)2.21823327
96Joint stiffness (HP:0001387)2.21093672
97Distal lower limb muscle weakness (HP:0009053)2.20007165
98Disproportionate tall stature (HP:0001519)2.18588463
99Skin nodule (HP:0200036)2.17199579
100Back pain (HP:0003418)2.15673447
101Mitral valve prolapse (HP:0001634)2.15357145
102Popliteal pterygium (HP:0009756)2.13862355
103Hyperglycinuria (HP:0003108)2.12806238
104Hypoventilation (HP:0002791)2.12720176
105Vertebral compression fractures (HP:0002953)2.12329946
106Coxa vara (HP:0002812)2.12176219
107Asymmetric septal hypertrophy (HP:0001670)2.11555296
108Blue sclerae (HP:0000592)2.11173000
109Spondylolisthesis (HP:0003302)2.09664249
110Hypertriglyceridemia (HP:0002155)2.08693998
111Joint hemorrhage (HP:0005261)2.08633375
112Aortic regurgitation (HP:0001659)2.07939188
113Cardiovascular calcification (HP:0011915)2.07463507
114Hypercholesterolemia (HP:0003124)2.07239248
115Systemic lupus erythematosus (HP:0002725)2.05850730
116Wide anterior fontanel (HP:0000260)2.05337933
117Abnormal enzyme/coenzyme activity (HP:0012379)2.05291847
118Orthostatic hypotension (HP:0001278)2.03421120
119Bowel diverticulosis (HP:0005222)2.03410610
120Insulin resistance (HP:0000855)2.01924267
121Hypercortisolism (HP:0001578)1.99350342
122Obstructive sleep apnea (HP:0002870)1.97482240
123Hyperacusis (HP:0010780)1.97236033
124Ectopia lentis (HP:0001083)1.96735369
125Hyperglycinemia (HP:0002154)1.96604595
126Abnormality of purine metabolism (HP:0004352)1.96305559
127Acanthosis nigricans (HP:0000956)1.95160866
128Venous abnormality (HP:0002624)1.95142734
129Aortic valve stenosis (HP:0001650)1.94939715
130Premature skin wrinkling (HP:0100678)1.94911513
131Abnormal platelet volume (HP:0011876)1.94394649
132Abnormality of alkaline phosphatase activity (HP:0004379)1.94147471
133Conjugated hyperbilirubinemia (HP:0002908)1.93919260
134Nonimmune hydrops fetalis (HP:0001790)1.93732085
135Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.93684758
136Stridor (HP:0010307)1.93262823
137Malnutrition (HP:0004395)1.92820968
138Bowing of the arm (HP:0006488)1.92616940
139Bowed forearm bones (HP:0003956)1.92616940
140Ovoid vertebral bodies (HP:0003300)1.91602916
141Cervical subluxation (HP:0003308)1.90917584
142Abnormality of proline metabolism (HP:0010907)1.90881859
143Hydroxyprolinuria (HP:0003080)1.90881859
144Generalized aminoaciduria (HP:0002909)1.90325105
145Steatorrhea (HP:0002570)1.90025561
146Wrist flexion contracture (HP:0001239)1.89843873
147Vaginal fistula (HP:0004320)1.89317869
148Aneurysm (HP:0002617)1.89050743
149Hepatocellular carcinoma (HP:0001402)1.88584523
150Exocrine pancreatic insufficiency (HP:0001738)1.87502940
151Hyperbilirubinemia (HP:0002904)1.87327804
152Abnormality of nucleobase metabolism (HP:0010932)1.86271545
153Right ventricular cardiomyopathy (HP:0011663)1.85696037
154Gout (HP:0001997)1.85664413
155Hyperparathyroidism (HP:0000843)1.85632492
156Emphysema (HP:0002097)1.83399798
157Short humerus (HP:0005792)1.83361219
158Abnormal cartilage morphology (HP:0002763)1.82211444
159Round ear (HP:0100830)1.82056565
160Congenital glaucoma (HP:0001087)1.81397755
161Venous insufficiency (HP:0005293)1.81164138
162Peritonitis (HP:0002586)1.81068469
163Increased CSF protein (HP:0002922)1.80935795
164Esophageal varix (HP:0002040)1.80911200
165Short nail (HP:0001799)1.80276511
166Camptodactyly of toe (HP:0001836)1.79911128
167Muscle fibrillation (HP:0010546)1.79811053
168Gastrointestinal dysmotility (HP:0002579)1.79649074
169Abnormality of aspartate family amino acid metabolism (HP:0010899)1.78614332
170Abnormality of glycine metabolism (HP:0010895)1.78109546
171Abnormality of serine family amino acid metabolism (HP:0010894)1.78109546
172Long toe (HP:0010511)1.77984121
173Renal duplication (HP:0000075)1.76715502
174Osteoarthritis (HP:0002758)1.75307292
175Hypoplasia of the iris (HP:0007676)1.74401776

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK155.78645582
2DDR24.18564340
3ICK3.69069995
4MYLK3.48177204
5ERN13.23489092
6PDGFRA2.72422082
7MAP3K112.62278544
8TRIB32.62229689
9BCKDK2.29436376
10PIM22.25881131
11DYRK1B2.22219985
12MAP3K62.12201231
13SIK12.09986601
14LIMK11.94224869
15INSRR1.91896460
16PINK11.87485986
17MATK1.85900016
18BMX1.83963076
19LATS21.72710323
20EPHA21.72417919
21PRPF4B1.68466619
22IRAK31.65703977
23CSK1.59832367
24ARAF1.55550284
25FLT31.53590161
26PRKD21.52101234
27PTK21.45697989
28LMTK21.42404749
29SMG11.41045888
30FGFR41.37615479
31NEK91.33944753
32CDK61.30797044
33RIPK11.26540354
34LATS11.26315257
35EPHB21.22746341
36DAPK11.18516229
37TRPM71.16959621
38MAP3K101.15188199
39AKT31.14835704
40TYRO31.13336320
41MOS1.12975011
42UHMK11.09770225
43MAPK111.08753649
44MAP3K31.08262011
45ILK1.07951615
46MET1.07927660
47PKN21.06970151
48GSK3A1.05672971
49NME21.05469201
50PRKD31.05398276
51CDC42BPA1.04300850
52MTOR1.03696600
53TESK21.02512630
54MAPKAPK31.02092801
55PIK3CG1.01217803
56TAOK31.00314739
57HIPK20.98994276
58FGR0.98685034
59PASK0.97995526
60RPS6KC10.97451754
61RPS6KL10.97451754
62DAPK30.97414497
63EEF2K0.97211982
64RPS6KA20.96732745
65STK380.95643043
66CDK70.95578248
67CDK120.94523762
68PTK60.92551175
69TIE10.86490041
70STK38L0.86361255
71GRK50.85710331
72RPS6KA60.85655968
73PDPK10.83395491
74DMPK0.81382439
75EPHA30.79801004
76FER0.77374598
77YES10.76838414
78FRK0.76326544
79PIM10.75593512
80MAP2K20.75515948
81PTK2B0.75302003
82TAOK20.73986955
83KIT0.71322084
84TESK10.70239995
85MST1R0.69604448
86MAP3K20.68235570
87MARK20.68174005
88TBK10.66708292
89PAK20.63260860
90PAK40.59950055
91ROCK10.59032142
92ROCK20.57978165
93PAK10.57918407
94TAOK10.57598365
95TTN0.57424353
96PRKAA10.55814045
97MAPK120.54876238
98MAPK70.54279306
99KDR0.54202585
100MAP2K10.54081725
101PAK30.53731398
102WNK30.52170353
103ERBB30.52001486
104MAPK40.51170717
105ADRBK10.50618783
106ZAP700.49825145
107ERBB40.49624079
108PDGFRB0.46748857
109CHUK0.46562310
110NTRK10.45397052
111KSR20.44979433
112RPS6KA10.44000689
113RPS6KA40.42837081
114STK30.42146956
115RET0.41135091
116FGFR10.40747172
117TYK20.39518229
118SRC0.38678357
119LRRK20.38635694
120DYRK30.38430084
121PRKAA20.36962769
122PRKG20.36934709
123EGFR0.36889358
124ERBB20.35412289
125MAP2K30.35274148
126RPS6KB20.34687941
127MAPK30.34103046
128AKT20.33811418
129ABL20.33715772
130MAPKAPK20.33695599
131CAMK10.32681146
132PRKD10.32564063
133MAPK10.32395983
134TGFBR20.32384472
135CDK11A0.32367625
136INSR0.31115535
137EPHB10.28475550
138CAMK1D0.27361730
139JAK20.26788549
140PRKCI0.25473961
141CAMK2G0.24122087
142MAP3K10.22981274

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.79743572
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.23383431
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.16404993
4Pentose and glucuronate interconversions_Homo sapiens_hsa000402.76029395
5Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.69261077
6Tryptophan metabolism_Homo sapiens_hsa003802.47914749
7Arginine biosynthesis_Homo sapiens_hsa002202.39312696
8Other glycan degradation_Homo sapiens_hsa005112.34622790
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.14104640
10Fatty acid metabolism_Homo sapiens_hsa012122.13557573
11Fatty acid degradation_Homo sapiens_hsa000712.09518038
12Fatty acid biosynthesis_Homo sapiens_hsa000612.07447867
13Nitrogen metabolism_Homo sapiens_hsa009102.05253849
14Complement and coagulation cascades_Homo sapiens_hsa046102.01524361
15Folate biosynthesis_Homo sapiens_hsa007901.97227547
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.93327029
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.88065691
18Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.87477051
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.84845513
20Selenocompound metabolism_Homo sapiens_hsa004501.83443868
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.83291820
22Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.78538796
23Sulfur metabolism_Homo sapiens_hsa009201.77520365
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.74059779
25Chemical carcinogenesis_Homo sapiens_hsa052041.71331450
26Starch and sucrose metabolism_Homo sapiens_hsa005001.64018608
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.62820374
28Arginine and proline metabolism_Homo sapiens_hsa003301.61632012
29Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.57251575
30Caffeine metabolism_Homo sapiens_hsa002321.55999534
31Peroxisome_Homo sapiens_hsa041461.54485487
32Amoebiasis_Homo sapiens_hsa051461.50541735
33Butanoate metabolism_Homo sapiens_hsa006501.50303228
34PPAR signaling pathway_Homo sapiens_hsa033201.48309572
35Dilated cardiomyopathy_Homo sapiens_hsa054141.47006838
36Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.45850126
37Histidine metabolism_Homo sapiens_hsa003401.44275989
38Fat digestion and absorption_Homo sapiens_hsa049751.43272266
39Steroid hormone biosynthesis_Homo sapiens_hsa001401.43186681
40Protein digestion and absorption_Homo sapiens_hsa049741.42651227
41Biosynthesis of amino acids_Homo sapiens_hsa012301.39682465
42Phenylalanine metabolism_Homo sapiens_hsa003601.33053962
43Sulfur relay system_Homo sapiens_hsa041221.31127778
44Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.29529720
45Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.26075687
46Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.24750062
47Glycosaminoglycan degradation_Homo sapiens_hsa005311.22535027
48Pentose phosphate pathway_Homo sapiens_hsa000301.21825041
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.19613433
50Galactose metabolism_Homo sapiens_hsa000521.16250910
51Retinol metabolism_Homo sapiens_hsa008301.16039275
52Lysine degradation_Homo sapiens_hsa003101.15937138
53Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.15866978
54Tyrosine metabolism_Homo sapiens_hsa003501.14724524
55AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.13749935
56Propanoate metabolism_Homo sapiens_hsa006401.13232051
57Bladder cancer_Homo sapiens_hsa052191.11862146
58beta-Alanine metabolism_Homo sapiens_hsa004101.11110257
59Glutathione metabolism_Homo sapiens_hsa004801.10986704
60Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.08489308
61Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.08178682
62Regulation of actin cytoskeleton_Homo sapiens_hsa048101.06972118
63Bile secretion_Homo sapiens_hsa049761.06899091
64ABC transporters_Homo sapiens_hsa020101.04211962
65Adipocytokine signaling pathway_Homo sapiens_hsa049201.04012361
66Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.99701153
67Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.99535154
68Pyruvate metabolism_Homo sapiens_hsa006200.98913217
69Platelet activation_Homo sapiens_hsa046110.97831885
70Malaria_Homo sapiens_hsa051440.96706837
71Vibrio cholerae infection_Homo sapiens_hsa051100.96134277
72Staphylococcus aureus infection_Homo sapiens_hsa051500.94184228
73Steroid biosynthesis_Homo sapiens_hsa001000.93767015
74Small cell lung cancer_Homo sapiens_hsa052220.91881501
75Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.91345382
76PI3K-Akt signaling pathway_Homo sapiens_hsa041510.90789687
77Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.87478250
78Carbon metabolism_Homo sapiens_hsa012000.86177917
79Fatty acid elongation_Homo sapiens_hsa000620.85689386
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.84345370
81Chronic myeloid leukemia_Homo sapiens_hsa052200.83495217
82Adherens junction_Homo sapiens_hsa045200.83069938
83Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.82374402
84* Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.81715018
85Pertussis_Homo sapiens_hsa051330.80632337
86Fructose and mannose metabolism_Homo sapiens_hsa000510.80594267
87Leukocyte transendothelial migration_Homo sapiens_hsa046700.77940137
88Cysteine and methionine metabolism_Homo sapiens_hsa002700.75496905
89One carbon pool by folate_Homo sapiens_hsa006700.75180996
90Gap junction_Homo sapiens_hsa045400.75001319
91Vascular smooth muscle contraction_Homo sapiens_hsa042700.74608702
92Endocytosis_Homo sapiens_hsa041440.73656715
93Circadian rhythm_Homo sapiens_hsa047100.70456578
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.68765331
95Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.65610117
96Lysosome_Homo sapiens_hsa041420.65120643
97Acute myeloid leukemia_Homo sapiens_hsa052210.62613662
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61146763
99Hippo signaling pathway_Homo sapiens_hsa043900.59754081
100Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.57340686
101Vitamin digestion and absorption_Homo sapiens_hsa049770.56940773
102Base excision repair_Homo sapiens_hsa034100.56758809
103Prion diseases_Homo sapiens_hsa050200.56455888
104Shigellosis_Homo sapiens_hsa051310.55754683
105cGMP-PKG signaling pathway_Homo sapiens_hsa040220.55401182
106Pancreatic cancer_Homo sapiens_hsa052120.52035627
107Rap1 signaling pathway_Homo sapiens_hsa040150.51747964
108VEGF signaling pathway_Homo sapiens_hsa043700.51524053
109Pathways in cancer_Homo sapiens_hsa052000.50800021
110Melanoma_Homo sapiens_hsa052180.50387653
111TGF-beta signaling pathway_Homo sapiens_hsa043500.49931631
112Protein export_Homo sapiens_hsa030600.49772654
113Melanogenesis_Homo sapiens_hsa049160.48875490
114Cyanoamino acid metabolism_Homo sapiens_hsa004600.48156276
115Neurotrophin signaling pathway_Homo sapiens_hsa047220.47863366
116Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47385622
117mTOR signaling pathway_Homo sapiens_hsa041500.47120381
118Notch signaling pathway_Homo sapiens_hsa043300.46871928
119Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45490009
120Phagosome_Homo sapiens_hsa041450.44815257
121Axon guidance_Homo sapiens_hsa043600.43787530
122Insulin resistance_Homo sapiens_hsa049310.43423236
123Hedgehog signaling pathway_Homo sapiens_hsa043400.42874687
124Glioma_Homo sapiens_hsa052140.42621252
125Aldosterone synthesis and secretion_Homo sapiens_hsa049250.42342583
126p53 signaling pathway_Homo sapiens_hsa041150.42293746
127Basal cell carcinoma_Homo sapiens_hsa052170.41653917
128Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41209664
129GnRH signaling pathway_Homo sapiens_hsa049120.40922124
130AMPK signaling pathway_Homo sapiens_hsa041520.40236051
131Cocaine addiction_Homo sapiens_hsa050300.39911930
132Glycerolipid metabolism_Homo sapiens_hsa005610.39837125
133Salmonella infection_Homo sapiens_hsa051320.38974551
134Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.37134782
135Mismatch repair_Homo sapiens_hsa034300.36747527
136N-Glycan biosynthesis_Homo sapiens_hsa005100.35908724
137Focal adhesion_Homo sapiens_hsa045100.34570591
138ECM-receptor interaction_Homo sapiens_hsa045120.33423029
139Insulin signaling pathway_Homo sapiens_hsa049100.32314134
140Metabolic pathways_Homo sapiens_hsa011000.31203929
141Renin-angiotensin system_Homo sapiens_hsa046140.31032130
142Thyroid cancer_Homo sapiens_hsa052160.30590321
143Glucagon signaling pathway_Homo sapiens_hsa049220.29916942
144Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.27856891
145Proteoglycans in cancer_Homo sapiens_hsa052050.27051549
146Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.26425992
147Central carbon metabolism in cancer_Homo sapiens_hsa052300.23915293

Most similar genes based on co-expression Upload to Enrichr

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