CYB5R4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: NCB5OR is a flavohemoprotein that contains functional domains found in both cytochrome b5 (CYB5A; MIM 613218) and CYB5 reductase (CYB5R3; MIM 613213) (Zhu et al., 1999 [PubMed 10611283]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1superoxide anion generation (GO:0042554)5.11890013
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.88673577
3regulation of B cell receptor signaling pathway (GO:0050855)4.25609704
4positive regulation by symbiont of host defense response (GO:0052509)4.22427527
5modulation by symbiont of host defense response (GO:0052031)4.22427527
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.22427527
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.22427527
8positive regulation by organism of defense response of other organism involved in symbiotic interact4.22427527
9modulation by symbiont of host immune response (GO:0052553)4.22427527
10response to host immune response (GO:0052572)4.20060240
11response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.20060240
12detection of other organism (GO:0098543)4.10479211
13negative regulation of granulocyte differentiation (GO:0030853)4.06865904
14detection of bacterium (GO:0016045)4.05335082
15regulation of gamma-delta T cell activation (GO:0046643)3.82342593
16response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.73666628
17response to host (GO:0075136)3.73666628
18response to host defenses (GO:0052200)3.73666628
19positive regulation of gamma-delta T cell activation (GO:0046645)3.73276608
20cellular response to ethanol (GO:0071361)3.64021602
21monoubiquitinated protein deubiquitination (GO:0035520)3.60140967
22microglial cell activation (GO:0001774)3.59248118
23G-protein coupled receptor internalization (GO:0002031)3.56226871
24regulation of gamma-delta T cell differentiation (GO:0045586)3.55722246
25leukocyte aggregation (GO:0070486)3.54094951
26neutrophil mediated immunity (GO:0002446)3.52644075
27neutrophil activation (GO:0042119)3.50319427
28indole-containing compound catabolic process (GO:0042436)3.47193187
29indolalkylamine catabolic process (GO:0046218)3.47193187
30tryptophan catabolic process (GO:0006569)3.47193187
31response to peptidoglycan (GO:0032494)3.45258632
32interferon-gamma production (GO:0032609)3.41445677
33negative regulation of DNA-dependent DNA replication (GO:2000104)3.37799005
34positive regulation of antigen processing and presentation (GO:0002579)3.37329504
35signal peptide processing (GO:0006465)3.36953156
36positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.34784463
37regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.29031248
38indolalkylamine metabolic process (GO:0006586)3.27621410
39positive regulation of interleukin-1 beta secretion (GO:0050718)3.25533218
40regulation of interleukin-12 biosynthetic process (GO:0045075)3.22646394
41granulocyte activation (GO:0036230)3.22526546
42neutrophil activation involved in immune response (GO:0002283)3.18842127
43dendritic cell migration (GO:0036336)3.15578869
44respiratory burst (GO:0045730)3.14316438
45regulation of DNA endoreduplication (GO:0032875)3.12196006
46positive regulation of mast cell activation (GO:0033005)3.12021002
47macrophage activation (GO:0042116)3.10108088
48negative regulation of mast cell activation (GO:0033004)3.09170125
49negative regulation of lymphocyte mediated immunity (GO:0002707)3.08592799
50tryptophan metabolic process (GO:0006568)3.08535588
51regulation of mast cell activation (GO:0033003)3.06506683
52neural tube formation (GO:0001841)3.06432957
53kynurenine metabolic process (GO:0070189)3.05657446
54cellular extravasation (GO:0045123)3.04735941
55dendritic cell chemotaxis (GO:0002407)3.00160692
56positive regulation of developmental pigmentation (GO:0048087)2.96737551
57B cell homeostasis (GO:0001782)2.95531869
58positive regulation of interleukin-1 secretion (GO:0050716)2.95480529
59regulation of interleukin-1 beta secretion (GO:0050706)2.95461595
60hepatocyte apoptotic process (GO:0097284)2.94122529
61myeloid cell activation involved in immune response (GO:0002275)2.92922422
62positive regulation of cellular amide metabolic process (GO:0034250)2.92147432
63immunoglobulin mediated immune response (GO:0016064)2.92114805
64regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.91871329
65detection of external biotic stimulus (GO:0098581)2.91691543
66interkinetic nuclear migration (GO:0022027)2.89894415
67NIK/NF-kappaB signaling (GO:0038061)2.89693747
68regulation of mast cell degranulation (GO:0043304)2.87831464
69regulation of MHC class II biosynthetic process (GO:0045346)2.87603303
70phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.86469963
71regulation of RIG-I signaling pathway (GO:0039535)2.86202582
72negative regulation of T cell mediated immunity (GO:0002710)2.85800496
73regulation of antigen processing and presentation (GO:0002577)2.84907434
74germinal center formation (GO:0002467)2.84292030
75mature B cell differentiation (GO:0002335)2.84089785
76protein K48-linked deubiquitination (GO:0071108)2.83426260
77negative regulation of immunoglobulin mediated immune response (GO:0002890)2.82050474
78negative regulation of B cell mediated immunity (GO:0002713)2.82050474
79negative regulation of cAMP-mediated signaling (GO:0043951)2.81897650
80modulation by virus of host process (GO:0019054)2.81753962
81establishment of protein localization to Golgi (GO:0072600)2.81723522
82negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.80881807
83positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.78773902
84positive regulation of B cell differentiation (GO:0045579)2.78588129
85regulation of mast cell activation involved in immune response (GO:0033006)2.76913717
86detection of biotic stimulus (GO:0009595)2.76210274
87positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.74944222
88NAD biosynthetic process (GO:0009435)2.74121951
89regulation of pigment cell differentiation (GO:0050932)2.73485220
90myeloid leukocyte mediated immunity (GO:0002444)2.72682744
91histone H3-K36 demethylation (GO:0070544)2.70862183
92positive regulation of granulocyte differentiation (GO:0030854)2.70230649
93regulation of germinal center formation (GO:0002634)2.69433612
94detection of molecule of bacterial origin (GO:0032490)2.69200381
95positive regulation of interferon-alpha production (GO:0032727)2.67523391
96negative regulation of B cell proliferation (GO:0030889)2.66345387
97response to interleukin-15 (GO:0070672)2.65793919
98regulation of granulocyte differentiation (GO:0030852)2.64701689
99regulation of alpha-beta T cell proliferation (GO:0046640)2.64298436
100modulation by symbiont of host cellular process (GO:0044068)2.63649144
101regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.63374381
102phospholipid translocation (GO:0045332)2.62654194
103lipid translocation (GO:0034204)2.62654194
104cellular response to interleukin-15 (GO:0071350)2.62622599
105DNA strand renaturation (GO:0000733)2.62374674
106negative regulation of adaptive immune response (GO:0002820)2.62261677
107antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.61756707
108antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.61756707
109positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.61745006
110pinocytosis (GO:0006907)2.61306057
111regulation of B cell differentiation (GO:0045577)2.59695896
112Arp2/3 complex-mediated actin nucleation (GO:0034314)2.59681938
113positive regulation of mast cell degranulation (GO:0043306)2.58997013
114positive regulation of mast cell activation involved in immune response (GO:0033008)2.58997013
115protein K11-linked deubiquitination (GO:0035871)2.58790775
116snRNA transcription (GO:0009301)2.57630555
117DNA integration (GO:0015074)2.57181491
118antigen processing and presentation of endogenous antigen (GO:0019883)2.56755240
119response to muramyl dipeptide (GO:0032495)2.56524902
120negative regulation of phagocytosis (GO:0050765)2.56225365
121macrophage activation involved in immune response (GO:0002281)2.55891466
122negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.55415897
123negative regulation of T-helper cell differentiation (GO:0045623)2.55415897
124production of molecular mediator involved in inflammatory response (GO:0002532)2.55339296
125cellular response to zinc ion (GO:0071294)2.55305319
126negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.55187539
127actin nucleation (GO:0045010)2.55184209
128defense response to protozoan (GO:0042832)2.54725245
129regulation of dendritic cell antigen processing and presentation (GO:0002604)2.53390425
130negative regulation of interleukin-1 beta production (GO:0032691)2.53088367
131negative regulation of leukocyte mediated immunity (GO:0002704)2.52779583
132regulation of interferon-alpha production (GO:0032647)2.52265665
133centriole assembly (GO:0098534)2.51914866
134T cell migration (GO:0072678)2.50467840
135protein K63-linked deubiquitination (GO:0070536)2.50249481
136mast cell activation (GO:0045576)2.50249470
137cytokine biosynthetic process (GO:0042089)2.49852175
138positive regulation of interleukin-1 beta production (GO:0032731)2.49698884
139daunorubicin metabolic process (GO:0044597)2.49514066
140polyketide metabolic process (GO:0030638)2.49514066
141doxorubicin metabolic process (GO:0044598)2.49514066
142cilium or flagellum-dependent cell motility (GO:0001539)2.49409482
143meiotic chromosome segregation (GO:0045132)2.48925642
144interferon-gamma-mediated signaling pathway (GO:0060333)2.48398835
145regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.48038739
146myeloid dendritic cell activation (GO:0001773)2.47612402
147energy homeostasis (GO:0097009)2.47070601
148negative regulation of interleukin-12 production (GO:0032695)2.45300717
149regulation of interleukin-1 secretion (GO:0050704)2.44645273
150negative regulation of cell killing (GO:0031342)2.43727000
151negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.43727000
152B cell receptor signaling pathway (GO:0050853)2.42315571
153regulation of interferon-beta biosynthetic process (GO:0045357)2.40921107

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human3.72703767
2IRF8_21731497_ChIP-ChIP_J774_Mouse3.56993756
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.54922185
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.19548948
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.14108403
6PCGF2_27294783_Chip-Seq_ESCs_Mouse3.08513459
7E2F7_22180533_ChIP-Seq_HELA_Human3.03240497
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.86361930
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.81584726
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.80392531
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.74978920
12PCGF2_27294783_Chip-Seq_NPCs_Mouse2.71530351
13SUZ12_27294783_Chip-Seq_NPCs_Mouse2.61624175
14NFE2_27457419_Chip-Seq_LIVER_Mouse2.59327261
15IRF8_27001747_Chip-Seq_BMDM_Mouse2.57812883
16SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.43790083
17Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.37276646
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.31205135
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.28580157
20EZH2_27294783_Chip-Seq_NPCs_Mouse2.26720680
21ZFP57_27257070_Chip-Seq_ESCs_Mouse2.22384285
22GBX2_23144817_ChIP-Seq_PC3_Human2.16348947
23NOTCH1_21737748_ChIP-Seq_TLL_Human1.92685767
24VDR_22108803_ChIP-Seq_LS180_Human1.91298118
25P53_22387025_ChIP-Seq_ESCs_Mouse1.91138830
26EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.89525032
27IGF1R_20145208_ChIP-Seq_DFB_Human1.88583704
28SUZ12_18555785_Chip-Seq_ESCs_Mouse1.87615364
29SMAD_19615063_ChIP-ChIP_OVARY_Human1.87339058
30STAT3_18555785_Chip-Seq_ESCs_Mouse1.85047435
31NMYC_18555785_Chip-Seq_ESCs_Mouse1.83514669
32E2F1_18555785_Chip-Seq_ESCs_Mouse1.82343881
33TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.82141617
34MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.80913534
35NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.80518263
36TAF15_26573619_Chip-Seq_HEK293_Human1.79809973
37NANOG_18555785_Chip-Seq_ESCs_Mouse1.79673671
38ER_23166858_ChIP-Seq_MCF-7_Human1.77443319
39EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.77300393
40SCL_19346495_ChIP-Seq_HPC-7_Human1.75958499
41OCT4_18555785_Chip-Seq_ESCs_Mouse1.74582183
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.71455163
43CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.70359310
44PU1_27457419_Chip-Seq_LIVER_Mouse1.69981820
45RUNX1_27457419_Chip-Seq_LIVER_Mouse1.69532260
46MYB_21317192_ChIP-Seq_ERMYB_Mouse1.67815524
47P300_18555785_Chip-Seq_ESCs_Mouse1.67396922
48CMYC_18555785_Chip-Seq_ESCs_Mouse1.66018777
49STAT4_19710469_ChIP-ChIP_TH1__Mouse1.65976545
50ZNF274_21170338_ChIP-Seq_K562_Hela1.63655410
51* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.63360896
52SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.63230483
53GATA1_22025678_ChIP-Seq_K562_Human1.62221907
54ESRRB_18555785_Chip-Seq_ESCs_Mouse1.60755694
55FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.60627959
56ZFX_18555785_Chip-Seq_ESCs_Mouse1.58825429
57OCT4_21477851_ChIP-Seq_ESCs_Mouse1.57431384
58CRX_20693478_ChIP-Seq_RETINA_Mouse1.56545584
59STAT3_23295773_ChIP-Seq_U87_Human1.55295330
60SOX2_18555785_Chip-Seq_ESCs_Mouse1.54386919
61CTCF_18555785_Chip-Seq_ESCs_Mouse1.53323610
62SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.53296345
63KLF4_18555785_Chip-Seq_ESCs_Mouse1.51773070
64SMAD1_18555785_Chip-Seq_ESCs_Mouse1.48766780
65RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.48714912
66SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.48629555
67GATA3_26560356_Chip-Seq_TH2_Human1.48360420
68CTBP2_25329375_ChIP-Seq_LNCAP_Human1.43430404
69ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.43260032
70FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.42198828
71PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.40142701
72VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.39920403
73PRDM14_20953172_ChIP-Seq_ESCs_Human1.38890820
74MYB_26560356_Chip-Seq_TH2_Human1.37699162
75* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.35324783
76GATA3_27048872_Chip-Seq_THYMUS_Human1.34652537
77PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.34563605
78TCF4_23295773_ChIP-Seq_U87_Human1.34164997
79* SPI1_23547873_ChIP-Seq_NB4_Human1.32253832
80BCAT_22108803_ChIP-Seq_LS180_Human1.31796444
81LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.31152098
82LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.30953110
83PU_27001747_Chip-Seq_BMDM_Mouse1.30579212
84SMAD4_21799915_ChIP-Seq_A2780_Human1.30577424
85RUNX_20019798_ChIP-Seq_JUKART_Human1.29871194
86TP63_19390658_ChIP-ChIP_HaCaT_Human1.26217675
87IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.25489116
88CBP_20019798_ChIP-Seq_JUKART_Human1.25489116
89KAP1_22055183_ChIP-Seq_ESCs_Mouse1.25207457
90CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.24252987
91TP53_16413492_ChIP-PET_HCT116_Human1.23225506
92* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22089029
93BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.20709868
94SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20671450
95PIAS1_25552417_ChIP-Seq_VCAP_Human1.20614616
96TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20470705
97PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20050422
98SMRT_27268052_Chip-Seq_Bcells_Human1.19701863
99CTBP1_25329375_ChIP-Seq_LNCAP_Human1.19077664
100EWS_26573619_Chip-Seq_HEK293_Human1.18378901
101NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.17641377
102GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.16836988
103TAL1_26923725_Chip-Seq_HPCs_Mouse1.16044768
104STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.15006846
105GATA2_21666600_ChIP-Seq_HMVEC_Human1.14321351
106RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.14276027
107MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.14210107
108FLI1_21867929_ChIP-Seq_TH2_Mouse1.13995960
109BRD4_27068464_Chip-Seq_AML-cells_Mouse1.13842397
110NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13592447
111CDX2_22108803_ChIP-Seq_LS180_Human1.11073925
112KDM2B_26808549_Chip-Seq_REH_Human1.10670512
113EGR1_23403033_ChIP-Seq_LIVER_Mouse1.09476759
114AR_25329375_ChIP-Seq_VCAP_Human1.08880185
115VDR_24787735_ChIP-Seq_THP-1_Human1.08716872
116RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.07796724
117CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07189554
118MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06652121
119FUS_26573619_Chip-Seq_HEK293_Human1.05554482
120MYB_26560356_Chip-Seq_TH1_Human1.05490958
121AHR_22903824_ChIP-Seq_MCF-7_Human1.03590097
122P300_19829295_ChIP-Seq_ESCs_Human1.03299772
123AR_21572438_ChIP-Seq_LNCaP_Human1.01924225
124ARNT_22903824_ChIP-Seq_MCF-7_Human1.01553454
125* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.01499943
126CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.01190299
127OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01011589
128FOXA1_21572438_ChIP-Seq_LNCaP_Human1.00160809
129TP53_18474530_ChIP-ChIP_U2OS_Human0.99637208
130SOX2_19829295_ChIP-Seq_ESCs_Human0.99546374
131NANOG_19829295_ChIP-Seq_ESCs_Human0.99546374
132SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99321948
133CDX2_19796622_ChIP-Seq_MESCs_Mouse0.98946982
134STAT1_17558387_ChIP-Seq_HELA_Human0.96123858
135EGR1_19374776_ChIP-ChIP_THP-1_Human0.95680791
136SPI1_23127762_ChIP-Seq_K562_Human0.94905469
137FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93964181
138TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93902616
139POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.93902616
140PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.93758514
141CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93734653
142AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93406033
143EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.92712609

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.71866320
2MP0001835_abnormal_antigen_presentation3.64728936
3MP0005174_abnormal_tail_pigmentation2.99094572
4MP0009785_altered_susceptibility_to2.83298744
5MP0003436_decreased_susceptibility_to2.72253020
6MP0000015_abnormal_ear_pigmentation2.63421053
7MP0001188_hyperpigmentation2.54091278
8MP0005387_immune_system_phenotype2.52140725
9MP0001790_abnormal_immune_system2.52140725
10MP0002148_abnormal_hypersensitivity_rea2.46374161
11MP0005671_abnormal_response_to2.43555159
12MP0002138_abnormal_hepatobiliary_system2.42070293
13MP0001800_abnormal_humoral_immune2.41332156
14MP0002419_abnormal_innate_immunity2.36074946
15MP0005025_abnormal_response_to2.29916369
16MP0002452_abnormal_antigen_presenting2.28522837
17MP0002396_abnormal_hematopoietic_system2.23606944
18MP0002102_abnormal_ear_morphology2.22060329
19MP0005000_abnormal_immune_tolerance2.17673492
20MP0002723_abnormal_immune_serum2.15909069
21MP0000490_abnormal_crypts_of2.14029016
22MP0008058_abnormal_DNA_repair2.13391006
23MP0000685_abnormal_immune_system2.11864113
24MP0001819_abnormal_immune_cell2.07103014
25MP0002420_abnormal_adaptive_immunity2.05303118
26MP0003646_muscle_fatigue2.04357198
27MP0002277_abnormal_respiratory_mucosa2.01029875
28MP0003195_calcinosis1.99842912
29MP0003724_increased_susceptibility_to1.98706587
30MP0005451_abnormal_body_composition1.96875049
31MP0004381_abnormal_hair_follicle1.85088548
32MP0006054_spinal_hemorrhage1.84617529
33MP0002095_abnormal_skin_pigmentation1.77360757
34MP0003763_abnormal_thymus_physiology1.70536734
35MP0002398_abnormal_bone_marrow1.67542599
36MP0005464_abnormal_platelet_physiology1.67131365
37MP0004808_abnormal_hematopoietic_stem1.64184217
38MP0003303_peritoneal_inflammation1.63557676
39MP0010155_abnormal_intestine_physiology1.63116837
40MP0008260_abnormal_autophagy1.61468027
41MP0000716_abnormal_immune_system1.60016061
42MP0001873_stomach_inflammation1.59776891
43MP0001501_abnormal_sleep_pattern1.58265347
44MP0002006_tumorigenesis1.57905033
45MP0009764_decreased_sensitivity_to1.57140719
46MP0003183_abnormal_peptide_metabolism1.55539811
47MP0002405_respiratory_system_inflammati1.54848965
48MP0002166_altered_tumor_susceptibility1.53175966
49MP0006292_abnormal_olfactory_placode1.51120832
50MP0001845_abnormal_inflammatory_respons1.45761180
51MP0003300_gastrointestinal_ulcer1.36379862
52MP0000858_altered_metastatic_potential1.36101161
53MP0005075_abnormal_melanosome_morpholog1.34914242
54MP0000371_diluted_coat_color1.32499379
55MP0004947_skin_inflammation1.31838335
56MP0000383_abnormal_hair_follicle1.31031738
57MP0000689_abnormal_spleen_morphology1.30424423
58MP0002429_abnormal_blood_cell1.27698398
59MP0000427_abnormal_hair_cycle1.25817261
60MP0003828_pulmonary_edema1.25196616
61MP0002722_abnormal_immune_system1.24135803
62MP0009278_abnormal_bone_marrow1.23878342
63MP0005397_hematopoietic_system_phenotyp1.23789365
64MP0001545_abnormal_hematopoietic_system1.23789365
65MP0003656_abnormal_erythrocyte_physiolo1.23633047
66MP0005167_abnormal_blood-brain_barrier1.23418413
67MP0004130_abnormal_muscle_cell1.23077179
68MP0010094_abnormal_chromosome_stability1.22783186
69MP0010307_abnormal_tumor_latency1.22107372
70MP0006082_CNS_inflammation1.19752892
71MP0003172_abnormal_lysosome_physiology1.19528181
72MP0001986_abnormal_taste_sensitivity1.19499291
73MP0003941_abnormal_skin_development1.19153157
74MP0005310_abnormal_salivary_gland1.19035630
75MP0004510_myositis1.18680457
76MP0003136_yellow_coat_color1.17534886
77MP0003111_abnormal_nucleus_morphology1.13072405
78MP0000372_irregular_coat_pigmentation1.12969996
79MP0008877_abnormal_DNA_methylation1.11939689
80MP0001853_heart_inflammation1.09194057
81MP0003787_abnormal_imprinting1.08560960
82MP0004883_abnormal_blood_vessel1.08348916
83MP0002928_abnormal_bile_duct1.07264343
84MP0002132_abnormal_respiratory_system1.07253836
85MP0003252_abnormal_bile_duct1.02603829
86MP0002332_abnormal_exercise_endurance1.02156808
87MP0002168_other_aberrant_phenotype1.01422155
88MP0000703_abnormal_thymus_morphology1.01355877
89MP0005645_abnormal_hypothalamus_physiol1.00467952
90MP0008469_abnormal_protein_level0.99459829
91MP0003448_altered_tumor_morphology0.99430387
92MP0001533_abnormal_skeleton_physiology0.97068006
93MP0009333_abnormal_splenocyte_physiolog0.94024709
94MP0004043_abnormal_pH_regulation0.93295448
95MP0005266_abnormal_metabolism0.90740517
96MP0003866_abnormal_defecation0.89900773
97MP0002998_abnormal_bone_remodeling0.88443826
98MP0008961_abnormal_basal_metabolism0.87806198
99MP0005551_abnormal_eye_electrophysiolog0.86537896
100MP0002009_preneoplasia0.86394279
101MP0001186_pigmentation_phenotype0.85539201
102MP0000579_abnormal_nail_morphology0.83560571
103MP0002933_joint_inflammation0.83197361
104MP0002075_abnormal_coat/hair_pigmentati0.83002712
105MP0005164_abnormal_response_to0.81406420
106MP0003693_abnormal_embryo_hatching0.80962201
107MP0000465_gastrointestinal_hemorrhage0.80706015
108MP0004484_altered_response_of0.80396401
109MP0004019_abnormal_vitamin_homeostasis0.79895862
110MP0001851_eye_inflammation0.79878410
111MP0001191_abnormal_skin_condition0.78562548
112MP0003045_fibrosis0.78469893
113MP0005409_darkened_coat_color0.77363128
114MP0003690_abnormal_glial_cell0.76807447
115MP0009697_abnormal_copulation0.76658485
116MP0008004_abnormal_stomach_pH0.76029639
117MP0003950_abnormal_plasma_membrane0.75795463
118MP0009046_muscle_twitch0.75178548
119MP0005410_abnormal_fertilization0.74650868
120MP0005376_homeostasis/metabolism_phenot0.74163676
121MP0000230_abnormal_systemic_arterial0.74149789
122MP0010386_abnormal_urinary_bladder0.74127191
123MP0000566_synostosis0.73871336
124MP0008057_abnormal_DNA_replication0.73794627
125MP0008007_abnormal_cellular_replicative0.70724792
126MP0000343_altered_response_to0.69859680
127* MP0002693_abnormal_pancreas_physiology0.69775803
128MP0003191_abnormal_cellular_cholesterol0.68874373
129MP0001663_abnormal_digestive_system0.68453832
130MP0009115_abnormal_fat_cell0.67690673
131MP0005647_abnormal_sex_gland0.67409506
132MP0005085_abnormal_gallbladder_physiolo0.67000950
133MP0002638_abnormal_pupillary_reflex0.66167537
134MP0003633_abnormal_nervous_system0.65491564
135MP0005253_abnormal_eye_physiology0.63800393

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.82746307
2Chromsome breakage (HP:0040012)5.26047080
3Eczematoid dermatitis (HP:0000976)5.08525966
4Recurrent abscess formation (HP:0002722)4.90926243
5Prostate neoplasm (HP:0100787)4.66174452
6Recurrent bacterial skin infections (HP:0005406)4.21910922
7Increased neuronal autofluorescent lipopigment (HP:0002074)4.14871462
8Increased cerebral lipofuscin (HP:0011813)3.88132959
9Genetic anticipation (HP:0003743)3.80260415
10Recurrent gram-negative bacterial infections (HP:0005420)3.76801294
11Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.75527226
12Gaze-evoked nystagmus (HP:0000640)3.45751105
13Recurrent fungal infections (HP:0002841)3.41862522
14Chronic obstructive pulmonary disease (HP:0006510)3.39889767
15Obstructive lung disease (HP:0006536)3.39889767
16Abnormality of the prostate (HP:0008775)3.36838170
17Mediastinal lymphadenopathy (HP:0100721)3.34525230
18Myositis (HP:0100614)3.30235686
19Abnormality of T cell number (HP:0011839)3.29981432
20Gingivitis (HP:0000230)3.28351888
21Recurrent cutaneous fungal infections (HP:0011370)3.23134245
22Chronic mucocutaneous candidiasis (HP:0002728)3.23134245
23Retrobulbar optic neuritis (HP:0100654)3.21168556
24Optic neuritis (HP:0100653)3.21168556
25T lymphocytopenia (HP:0005403)3.18546400
26Abnormality of DNA repair (HP:0003254)3.07743781
27Clubbing of toes (HP:0100760)2.91130818
28Upper limb muscle weakness (HP:0003484)2.90292529
29Meningitis (HP:0001287)2.89287380
30Recurrent skin infections (HP:0001581)2.87049023
31Hyperventilation (HP:0002883)2.86774889
32Aplasia/Hypoplasia of the uvula (HP:0010293)2.80750136
33Progressive cerebellar ataxia (HP:0002073)2.80285280
34Stomatitis (HP:0010280)2.79424026
35Attenuation of retinal blood vessels (HP:0007843)2.75475128
36Duplicated collecting system (HP:0000081)2.73393675
37Abnormality of the preputium (HP:0100587)2.72594517
38Orchitis (HP:0100796)2.71440221
39Febrile seizures (HP:0002373)2.69506695
40Clumsiness (HP:0002312)2.68621923
41Chronic otitis media (HP:0000389)2.67489450
42Abnormality of macrophages (HP:0004311)2.65570794
43Stomach cancer (HP:0012126)2.65136540
44Hematochezia (HP:0002573)2.61090540
45Autoimmune hemolytic anemia (HP:0001890)2.57121946
46Recurrent pneumonia (HP:0006532)2.56936268
47Gastrointestinal infarctions (HP:0005244)2.56771377
48Abnormal delayed hypersensitivity skin test (HP:0002963)2.56609900
49Pancreatic cysts (HP:0001737)2.53476094
50Abnormality of chromosome stability (HP:0003220)2.52385723
51Facial diplegia (HP:0001349)2.50115951
52Chronic diarrhea (HP:0002028)2.49642796
53Prolonged bleeding time (HP:0003010)2.49173739
54Abnormality of the renal collecting system (HP:0004742)2.47999776
55Protruding tongue (HP:0010808)2.47333592
56Recurrent viral infections (HP:0004429)2.45260925
57Abnormality of T cells (HP:0002843)2.44420758
58Meckel diverticulum (HP:0002245)2.43116327
59Fair hair (HP:0002286)2.41833744
60Periodontitis (HP:0000704)2.39429454
61Encephalitis (HP:0002383)2.38868614
62Abnormality of the renal cortex (HP:0011035)2.38396944
63Vasculitis (HP:0002633)2.35174435
64Abnormality of the ileum (HP:0001549)2.29597378
65Recurrent sinusitis (HP:0011108)2.28503121
66Elevated erythrocyte sedimentation rate (HP:0003565)2.27603883
67Albinism (HP:0001022)2.24864199
68Central scotoma (HP:0000603)2.23063710
69Generalized hypopigmentation of hair (HP:0011358)2.22884134
70Congenital sensorineural hearing impairment (HP:0008527)2.20729233
71Leukocytosis (HP:0001974)2.20619379
72Chest pain (HP:0100749)2.19454303
73Constricted visual fields (HP:0001133)2.19238973
74Reduced antithrombin III activity (HP:0001976)2.17098027
75Widely spaced teeth (HP:0000687)2.16635514
76Inflammation of the large intestine (HP:0002037)2.13188384
77Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.11985925
78Abnormality of the carotid arteries (HP:0005344)2.11826412
79Hypochromic microcytic anemia (HP:0004840)2.11440385
80Cheilitis (HP:0100825)2.10393046
81Recurrent lower respiratory tract infections (HP:0002783)2.09338512
82Gingival bleeding (HP:0000225)2.08790178
83Mesomelia (HP:0003027)2.07626966
84Autoimmune thrombocytopenia (HP:0001973)2.06216140
85Osteomyelitis (HP:0002754)2.05556036
86Panhypogammaglobulinemia (HP:0003139)2.03090977
87Alveolar cell carcinoma (HP:0006519)2.02956745
88Congenital stationary night blindness (HP:0007642)2.02808684
89Abolished electroretinogram (ERG) (HP:0000550)2.02687184
90Hemoptysis (HP:0002105)2.02123178
91Ectopic kidney (HP:0000086)2.00500523
92Abnormality of the fingertips (HP:0001211)2.00304490
93Acute hepatic failure (HP:0006554)1.99939920
94Lip pit (HP:0100267)1.99133239
95Pancreatic fibrosis (HP:0100732)1.98628179
96IgM deficiency (HP:0002850)1.98288374
97Progressive inability to walk (HP:0002505)1.98135159
98Pulmonary embolism (HP:0002204)1.97613651
99Abnormality of eosinophils (HP:0001879)1.97453295
100Renal cortical cysts (HP:0000803)1.96067037
101Tubulointerstitial nephritis (HP:0001970)1.95661740
102Keratoconjunctivitis sicca (HP:0001097)1.95393399
103Pulmonary infiltrates (HP:0002113)1.94647188
104Acute myeloid leukemia (HP:0004808)1.94099457
105Decreased circulating renin level (HP:0003351)1.93816306
106Gastrointestinal inflammation (HP:0004386)1.90569703
107Vacuolated lymphocytes (HP:0001922)1.90248256
108Keratoconjunctivitis (HP:0001096)1.90142774
109Absent/shortened dynein arms (HP:0200106)1.89487605
110Dynein arm defect of respiratory motile cilia (HP:0012255)1.89487605
111Basal ganglia calcification (HP:0002135)1.87632287
112Leukopenia (HP:0001882)1.84976471
113Abnormality of B cell number (HP:0010975)1.84784679
114Absent speech (HP:0001344)1.84397046
115Episodic fever (HP:0001954)1.84382684
116Decreased electroretinogram (ERG) amplitude (HP:0000654)1.84058038
117Increased IgE level (HP:0003212)1.83841404
118Dysmetric saccades (HP:0000641)1.83281535
119Agammaglobulinemia (HP:0004432)1.82408447
120Myelodysplasia (HP:0002863)1.79660959
121Pustule (HP:0200039)1.78621460
122Bone marrow hypocellularity (HP:0005528)1.78129496
123Neoplasm of the tracheobronchial system (HP:0100552)1.77985268
124Hypochromic anemia (HP:0001931)1.77939022
125IgG deficiency (HP:0004315)1.77666836
126Abnormality of the pleura (HP:0002103)1.77350528
127Abnormality of male internal genitalia (HP:0000022)1.76455401
128Arterial thrombosis (HP:0004420)1.76237639
129Gangrene (HP:0100758)1.76134017
130Epistaxis (HP:0000421)1.75803503
131Thyroiditis (HP:0100646)1.75796517
132Increased IgM level (HP:0003496)1.75590787
133Distal lower limb muscle weakness (HP:0009053)1.75439478
134Colitis (HP:0002583)1.74565891
135Tetany (HP:0001281)1.74278192
136True hermaphroditism (HP:0010459)1.73563430
137Spontaneous hematomas (HP:0007420)1.72171724
138Abnormality of the renal medulla (HP:0100957)1.72118644
139Polyneuropathy (HP:0001271)1.71748987
140Premature loss of primary teeth (HP:0006323)1.71355686
141Abnormality of T cell physiology (HP:0011840)1.71326537
142Eosinophilia (HP:0001880)1.70140316
143Joint hemorrhage (HP:0005261)1.69789407
144Abnormality of binocular vision (HP:0011514)1.69679843
145Diplopia (HP:0000651)1.69679843
146Vertigo (HP:0002321)1.69243009
147Glomerulopathy (HP:0100820)1.69174559
148Chronic hepatic failure (HP:0100626)1.68899687
149Urticaria (HP:0001025)1.68390385
150Lymphopenia (HP:0001888)1.66844790
151Absent frontal sinuses (HP:0002688)1.66393882

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK3.92502342
2TXK3.32726353
3ACVR1B3.22257206
4IRAK43.20489856
5MAP3K143.12070431
6EIF2AK22.90693541
7IRAK32.64421208
8TAOK32.53630861
9TEC2.52364260
10RIPK42.49129541
11ZAK2.35919304
12CASK2.26374747
13INSRR2.04534103
14YES11.95247865
15MAP4K11.94341769
16JAK11.88094257
17STK161.82304126
18IKBKE1.80416039
19GRK11.77900964
20JAK31.76646830
21TYK21.65298645
22KIT1.56400026
23BTK1.49499017
24IKBKB1.44241989
25NUAK11.39224714
26TBK11.29234205
27ZAP701.27220726
28EPHA31.24861133
29TNIK1.21374583
30HCK1.20029303
31LYN1.15340232
32PTK2B1.14403939
33SRPK11.12975031
34MARK31.12303497
35RPS6KA41.11516733
36CSK1.11023186
37SYK1.10358982
38SIK21.08295689
39SIK31.05756572
40IRAK11.04845515
41NLK1.02733560
42CSF1R1.00604166
43DYRK30.99688193
44TNK20.98754901
45CAMKK20.98658516
46FRK0.98658297
47SGK20.98269761
48ITK0.97194094
49PIM10.96688647
50FES0.96222804
51OXSR10.95035829
52AKT30.94315483
53FGFR30.93919426
54BMPR20.93669286
55ADRBK20.93145396
56LCK0.92747453
57CLK10.90895589
58CDK120.89938769
59ADRBK10.89623695
60CDK90.88452683
61CHUK0.86035980
62STK40.84533204
63STK30.82224817
64PIK3CG0.80643190
65ATR0.80627467
66MAP3K130.80154804
67NEK20.79729101
68STK240.77892958
69STK380.75704946
70ERBB30.75493228
71FLT30.73214146
72PLK40.70531343
73PDK10.70141841
74DAPK20.69539882
75TGFBR20.69386419
76MAP3K50.68476187
77NEK90.68162188
78CDK30.65470750
79MAP3K70.64637443
80MKNK20.64502742
81MAP4K20.64371633
82TAOK20.64363586
83PRKAA20.63144583
84FER0.61065412
85JAK20.60160742
86MELK0.60115318
87TRPM70.59920631
88MAP3K20.59432739
89PINK10.58971557
90MAP2K30.58736653
91TLK10.57928630
92MAP3K60.57392692
93FGFR40.56683721
94FGR0.56392507
95ABL10.55312914
96SGK30.55111054
97MST1R0.54348905
98MAPK130.53350349
99BRD40.53346224
100CAMK1D0.51358169
101MAP2K60.50173535
102MAP3K30.50096797
103CAMK1G0.49410715
104WNK30.47987036
105GRK70.46831467
106TTK0.45011113
107LATS10.44796622
108PRKCQ0.44366197
109STK110.43862767
110VRK10.42808546
111BMPR1B0.40657385
112WNK10.40508829
113MUSK0.40468512
114IRAK20.40308632
115NME20.38609103
116NTRK30.37970537
117MAP3K40.37859163
118STK38L0.37362699
119TGFBR10.36771706
120MAPK110.35042908
121SGK10.34660733
122RPS6KA60.34314259
123CDK60.34227048
124CDK190.34020015
125PAK30.33963641
126PIK3CA0.33819104
127GRK60.33498792
128CAMK40.33496035
129MATK0.32858957
130PRKCD0.32774786
131MAP2K70.32346420
132PRKCE0.31774959
133PRKCH0.30961817

Predicted pathways (KEGG)

RankGene SetZ-score
1NF-kappa B signaling pathway_Homo sapiens_hsa040642.64636200
2Intestinal immune network for IgA production_Homo sapiens_hsa046722.36639540
3Leishmaniasis_Homo sapiens_hsa051402.32772807
4Fanconi anemia pathway_Homo sapiens_hsa034602.25731545
5Primary immunodeficiency_Homo sapiens_hsa053402.25007548
6Measles_Homo sapiens_hsa051622.18100635
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.06004249
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.04758482
9RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.94364969
10Hematopoietic cell lineage_Homo sapiens_hsa046401.91096806
11Osteoclast differentiation_Homo sapiens_hsa043801.90920568
12Toll-like receptor signaling pathway_Homo sapiens_hsa046201.89193686
13NOD-like receptor signaling pathway_Homo sapiens_hsa046211.81672599
14Graft-versus-host disease_Homo sapiens_hsa053321.79917803
15Herpes simplex infection_Homo sapiens_hsa051681.76190201
16Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.75321058
17Homologous recombination_Homo sapiens_hsa034401.66972692
18Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.64139906
19Allograft rejection_Homo sapiens_hsa053301.63921430
20Other glycan degradation_Homo sapiens_hsa005111.62787407
21Jak-STAT signaling pathway_Homo sapiens_hsa046301.60927412
22TNF signaling pathway_Homo sapiens_hsa046681.56790804
23Staphylococcus aureus infection_Homo sapiens_hsa051501.55302367
24Influenza A_Homo sapiens_hsa051641.54242377
25B cell receptor signaling pathway_Homo sapiens_hsa046621.53275129
26Non-homologous end-joining_Homo sapiens_hsa034501.47402409
27Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.43398831
28Dorso-ventral axis formation_Homo sapiens_hsa043201.41972324
29Glycosaminoglycan degradation_Homo sapiens_hsa005311.37820233
30Tuberculosis_Homo sapiens_hsa051521.37777814
31Autoimmune thyroid disease_Homo sapiens_hsa053201.26912217
32Asthma_Homo sapiens_hsa053101.26760944
33Chemokine signaling pathway_Homo sapiens_hsa040621.23729986
34Malaria_Homo sapiens_hsa051441.21976931
35Legionellosis_Homo sapiens_hsa051341.14724647
36p53 signaling pathway_Homo sapiens_hsa041151.14693981
37Base excision repair_Homo sapiens_hsa034101.13898270
38Transcriptional misregulation in cancer_Homo sapiens_hsa052021.13524371
39Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.09905342
40Toxoplasmosis_Homo sapiens_hsa051451.08253152
41Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.06064173
42ABC transporters_Homo sapiens_hsa020101.05639624
43T cell receptor signaling pathway_Homo sapiens_hsa046601.04797820
44Sphingolipid metabolism_Homo sapiens_hsa006001.00896546
45Apoptosis_Homo sapiens_hsa042101.00741106
46Tryptophan metabolism_Homo sapiens_hsa003800.99304254
47Pertussis_Homo sapiens_hsa051330.98969274
48Vitamin digestion and absorption_Homo sapiens_hsa049770.98570563
49Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.93729238
50Hepatitis B_Homo sapiens_hsa051610.93138881
51Hepatitis C_Homo sapiens_hsa051600.92846078
52Systemic lupus erythematosus_Homo sapiens_hsa053220.91768140
53Rheumatoid arthritis_Homo sapiens_hsa053230.91223096
54Antigen processing and presentation_Homo sapiens_hsa046120.89737949
55Inositol phosphate metabolism_Homo sapiens_hsa005620.89668250
56alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.89314627
57Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.84821402
58Nitrogen metabolism_Homo sapiens_hsa009100.83074473
59Phagosome_Homo sapiens_hsa041450.82640759
60Olfactory transduction_Homo sapiens_hsa047400.82286593
61Type II diabetes mellitus_Homo sapiens_hsa049300.81865854
62Leukocyte transendothelial migration_Homo sapiens_hsa046700.81442712
63Acute myeloid leukemia_Homo sapiens_hsa052210.80020585
64Caffeine metabolism_Homo sapiens_hsa002320.79443023
65Shigellosis_Homo sapiens_hsa051310.76315473
66Ether lipid metabolism_Homo sapiens_hsa005650.76085439
67Morphine addiction_Homo sapiens_hsa050320.75735277
68Phosphatidylinositol signaling system_Homo sapiens_hsa040700.74780834
69Salmonella infection_Homo sapiens_hsa051320.74610913
70Viral myocarditis_Homo sapiens_hsa054160.73638942
71Linoleic acid metabolism_Homo sapiens_hsa005910.73289222
72Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.72849156
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69729322
74One carbon pool by folate_Homo sapiens_hsa006700.67404343
75Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67282345
76Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.67088015
77African trypanosomiasis_Homo sapiens_hsa051430.66864099
78Prolactin signaling pathway_Homo sapiens_hsa049170.66324523
79Glycerolipid metabolism_Homo sapiens_hsa005610.64799383
80Taste transduction_Homo sapiens_hsa047420.64682781
81Small cell lung cancer_Homo sapiens_hsa052220.64267025
82Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.63552022
83Vascular smooth muscle contraction_Homo sapiens_hsa042700.63175348
84Arachidonic acid metabolism_Homo sapiens_hsa005900.61194867
85Butanoate metabolism_Homo sapiens_hsa006500.61171283
86Pancreatic cancer_Homo sapiens_hsa052120.60496178
87Lysine degradation_Homo sapiens_hsa003100.60493495
88DNA replication_Homo sapiens_hsa030300.59917868
89Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58170830
90Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.58125178
91Serotonergic synapse_Homo sapiens_hsa047260.57200784
92Ovarian steroidogenesis_Homo sapiens_hsa049130.56986915
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.56555356
94Epstein-Barr virus infection_Homo sapiens_hsa051690.56248185
95Lysosome_Homo sapiens_hsa041420.56097548
96Calcium signaling pathway_Homo sapiens_hsa040200.55444615
97Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.54479773
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.54121195
99Type I diabetes mellitus_Homo sapiens_hsa049400.53763547
100Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53451025
101Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.53319130
102Phospholipase D signaling pathway_Homo sapiens_hsa040720.52729247
103Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.52113991
104Salivary secretion_Homo sapiens_hsa049700.51980057
105Viral carcinogenesis_Homo sapiens_hsa052030.51943075
106Adipocytokine signaling pathway_Homo sapiens_hsa049200.51921871
107Chronic myeloid leukemia_Homo sapiens_hsa052200.50664859
108Insulin resistance_Homo sapiens_hsa049310.50556560
109Renin-angiotensin system_Homo sapiens_hsa046140.49852031
110Long-term depression_Homo sapiens_hsa047300.49820418
111Primary bile acid biosynthesis_Homo sapiens_hsa001200.49700884
112Platelet activation_Homo sapiens_hsa046110.47984938
113FoxO signaling pathway_Homo sapiens_hsa040680.47815310
114SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47511033
115Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.47423274
116Renin secretion_Homo sapiens_hsa049240.46554820
117Oxytocin signaling pathway_Homo sapiens_hsa049210.44922091
118Nucleotide excision repair_Homo sapiens_hsa034200.44356236
119Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43949618
120Cholinergic synapse_Homo sapiens_hsa047250.43282880
121mTOR signaling pathway_Homo sapiens_hsa041500.43255913
122AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.42615508
123Non-small cell lung cancer_Homo sapiens_hsa052230.42496501
124Mismatch repair_Homo sapiens_hsa034300.42422113
125Circadian entrainment_Homo sapiens_hsa047130.42381814
126Basal transcription factors_Homo sapiens_hsa030220.40427922
127Regulation of autophagy_Homo sapiens_hsa041400.40237854
128Steroid hormone biosynthesis_Homo sapiens_hsa001400.39439474
129beta-Alanine metabolism_Homo sapiens_hsa004100.39227025
130HTLV-I infection_Homo sapiens_hsa051660.38820933
131Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38675912
132Phototransduction_Homo sapiens_hsa047440.38652634
133Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.38362125
134Cell cycle_Homo sapiens_hsa041100.36240863
135MicroRNAs in cancer_Homo sapiens_hsa052060.32766924

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