CYB5RL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1aminoglycoside antibiotic metabolic process (GO:0030647)8.15265626
2detection of molecule of bacterial origin (GO:0032490)5.77260299
3L-fucose catabolic process (GO:0042355)5.00913439
4fucose catabolic process (GO:0019317)5.00913439
5L-fucose metabolic process (GO:0042354)5.00913439
6behavioral response to nicotine (GO:0035095)4.70699004
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.44748297
8L-phenylalanine catabolic process (GO:0006559)4.44748297
9detection of external biotic stimulus (GO:0098581)4.44026930
10aromatic amino acid family catabolic process (GO:0009074)4.35782517
11indole-containing compound catabolic process (GO:0042436)4.28633819
12indolalkylamine catabolic process (GO:0046218)4.28633819
13tryptophan catabolic process (GO:0006569)4.28633819
14detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.27848867
15L-phenylalanine metabolic process (GO:0006558)4.21636011
16erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.21636011
17tryptophan metabolic process (GO:0006568)4.03541774
18cellular ketone body metabolic process (GO:0046950)4.01760942
19energy homeostasis (GO:0097009)3.94186852
20phosphate ion homeostasis (GO:0055062)3.93864861
21trivalent inorganic anion homeostasis (GO:0072506)3.93864861
22regulation of hippo signaling (GO:0035330)3.91637647
23detection of light stimulus involved in sensory perception (GO:0050962)3.80109384
24detection of light stimulus involved in visual perception (GO:0050908)3.80109384
25regulation of posttranscriptional gene silencing (GO:0060147)3.73672794
26regulation of gene silencing by miRNA (GO:0060964)3.73672794
27regulation of gene silencing by RNA (GO:0060966)3.73672794
28amine catabolic process (GO:0009310)3.63454487
29cellular biogenic amine catabolic process (GO:0042402)3.63454487
30ketone body metabolic process (GO:1902224)3.62132774
31detection of biotic stimulus (GO:0009595)3.61308659
32indole-containing compound metabolic process (GO:0042430)3.60868668
33prenylation (GO:0097354)3.59270695
34protein prenylation (GO:0018342)3.59270695
35cellular anion homeostasis (GO:0030002)3.56745335
36positive regulation of lipoprotein lipase activity (GO:0051006)3.52986151
37positive regulation of triglyceride lipase activity (GO:0061365)3.52986151
38negative regulation of translation, ncRNA-mediated (GO:0040033)3.48190453
39regulation of translation, ncRNA-mediated (GO:0045974)3.48190453
40negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.48190453
41cilium or flagellum-dependent cell motility (GO:0001539)3.40624157
42glycoside metabolic process (GO:0016137)3.35380698
43photoreceptor cell maintenance (GO:0045494)3.34794868
44oxidative demethylation (GO:0070989)3.34538381
45nucleotide transmembrane transport (GO:1901679)3.33924149
46regulation of activation of Janus kinase activity (GO:0010533)3.31474011
47neural tube formation (GO:0001841)3.30959917
48NAD biosynthetic process (GO:0009435)3.30571608
49reflex (GO:0060004)3.25898270
50negative regulation of cytosolic calcium ion concentration (GO:0051481)3.24158721
51primary amino compound metabolic process (GO:1901160)3.19934876
52indolalkylamine metabolic process (GO:0006586)3.17644775
53replication fork processing (GO:0031297)3.16563231
54aromatic amino acid family metabolic process (GO:0009072)3.14315006
55positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.12559145
56signal peptide processing (GO:0006465)3.12177862
57interkinetic nuclear migration (GO:0022027)3.10782900
58behavioral response to ethanol (GO:0048149)3.09023270
59serotonin metabolic process (GO:0042428)3.08938745
60branched-chain amino acid catabolic process (GO:0009083)3.06713349
61piRNA metabolic process (GO:0034587)3.06051972
62sulfate transmembrane transport (GO:1902358)3.05681357
63monoubiquitinated protein deubiquitination (GO:0035520)3.04769923
64response to pheromone (GO:0019236)3.04365561
65gamma-aminobutyric acid transport (GO:0015812)3.04139479
66kynurenine metabolic process (GO:0070189)3.04109213
67DNA deamination (GO:0045006)3.02863823
68reciprocal DNA recombination (GO:0035825)3.02366613
69reciprocal meiotic recombination (GO:0007131)3.02366613
70positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.01495919
71double-strand break repair via homologous recombination (GO:0000724)3.00609087
72sulfation (GO:0051923)3.00449859
73protein K11-linked deubiquitination (GO:0035871)3.00282354
74recombinational repair (GO:0000725)2.97396020
75negative regulation of digestive system process (GO:0060457)2.95435328
76snRNA transcription (GO:0009301)2.94560816
77benzene-containing compound metabolic process (GO:0042537)2.94404375
78DNA methylation involved in gamete generation (GO:0043046)2.91514920
79triglyceride homeostasis (GO:0070328)2.89464528
80acylglycerol homeostasis (GO:0055090)2.89464528
81glyoxylate metabolic process (GO:0046487)2.87959895
82branched-chain amino acid metabolic process (GO:0009081)2.87885220
83rRNA catabolic process (GO:0016075)2.87588654
84positive regulation of developmental pigmentation (GO:0048087)2.87369322
85estrogen biosynthetic process (GO:0006703)2.87015665
86detection of other organism (GO:0098543)2.86549366
87coenzyme catabolic process (GO:0009109)2.86237299
88axoneme assembly (GO:0035082)2.82425375
89preassembly of GPI anchor in ER membrane (GO:0016254)2.81380299
90detection of bacterium (GO:0016045)2.77999821
91homocysteine metabolic process (GO:0050667)2.77837048
92histone H3-K9 methylation (GO:0051567)2.77034326
93imidazole-containing compound metabolic process (GO:0052803)2.76353593
94negative regulation of macroautophagy (GO:0016242)2.76257688
95G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.76099764
96thyroid hormone metabolic process (GO:0042403)2.75511769
97regulation of rhodopsin mediated signaling pathway (GO:0022400)2.75032864
98protein import into peroxisome matrix (GO:0016558)2.74595734
99L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.74307510
100quinone metabolic process (GO:1901661)2.73176607
101nonmotile primary cilium assembly (GO:0035058)2.71551420
102amino-acid betaine metabolic process (GO:0006577)2.70662501
103protein K48-linked deubiquitination (GO:0071108)2.70361437
104exogenous drug catabolic process (GO:0042738)2.70295225
105rhodopsin mediated signaling pathway (GO:0016056)2.69945762
106phospholipid efflux (GO:0033700)2.69436794
107DNA demethylation (GO:0080111)2.69341038
108sulfate transport (GO:0008272)2.68860021
109mannosylation (GO:0097502)2.67613932
110epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.64959878
111neuronal action potential (GO:0019228)2.64781230
112methionine biosynthetic process (GO:0009086)2.64022081
113retinal cone cell development (GO:0046549)2.63576978
114fatty acid beta-oxidation (GO:0006635)2.62343914
115water-soluble vitamin biosynthetic process (GO:0042364)2.62180908
116nicotinamide nucleotide biosynthetic process (GO:0019359)2.61491074
117pyridine nucleotide biosynthetic process (GO:0019363)2.61491074
118regulation of mitochondrial translation (GO:0070129)2.59918738
119cilium organization (GO:0044782)2.58990963
120positive regulation of cholesterol efflux (GO:0010875)2.58969203
121alpha-amino acid catabolic process (GO:1901606)2.58470849
122fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.58122718
123regulation of nuclear cell cycle DNA replication (GO:0033262)2.58062118
124valine metabolic process (GO:0006573)2.57470000
125positive regulation of cellular amide metabolic process (GO:0034250)2.56860409
126negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.56727690
127short-chain fatty acid metabolic process (GO:0046459)2.56249162
128spinal cord motor neuron differentiation (GO:0021522)2.56199582
129tyrosine metabolic process (GO:0006570)2.56192860
130negative regulation of lipase activity (GO:0060192)2.55659403
131positive regulation of protein sumoylation (GO:0033235)2.54063815
132detection of mechanical stimulus involved in sensory perception (GO:0050974)2.53715698
133bile acid biosynthetic process (GO:0006699)2.53568705
134meiotic chromosome segregation (GO:0045132)2.52050905
135cilium assembly (GO:0042384)2.51990929
136regulation of sarcomere organization (GO:0060297)2.51796856
137regulation of establishment of cell polarity (GO:2000114)2.51623081
138negative regulation of mast cell activation (GO:0033004)2.51257054
139inner ear receptor stereocilium organization (GO:0060122)2.50434548
140androgen metabolic process (GO:0008209)2.50321395
141ceramide catabolic process (GO:0046514)2.50297027
142RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.49394376
143high-density lipoprotein particle remodeling (GO:0034375)2.47714688
144tachykinin receptor signaling pathway (GO:0007217)2.47592780
145positive regulation of sterol transport (GO:0032373)2.47445094
146positive regulation of cholesterol transport (GO:0032376)2.47445094
147cellular response to sterol (GO:0036315)2.47404830
148establishment of protein localization to Golgi (GO:0072600)2.47253088
149fatty acid catabolic process (GO:0009062)2.45721915
150auditory receptor cell stereocilium organization (GO:0060088)2.45165250
151biotin metabolic process (GO:0006768)2.44873018
152fatty acid oxidation (GO:0019395)2.44389365
153somatic hypermutation of immunoglobulin genes (GO:0016446)2.44373600
154somatic diversification of immune receptors via somatic mutation (GO:0002566)2.44373600
155centriole replication (GO:0007099)2.43543114
156drug catabolic process (GO:0042737)2.43493740
157vitamin biosynthetic process (GO:0009110)2.41838108
158gene silencing by RNA (GO:0031047)2.40107688
159GPI anchor biosynthetic process (GO:0006506)2.39674376
160fucosylation (GO:0036065)2.39581282
161cornea development in camera-type eye (GO:0061303)2.39090981
162lipid oxidation (GO:0034440)2.38798726
163phosphatidylinositol acyl-chain remodeling (GO:0036149)2.38470202
164kidney morphogenesis (GO:0060993)2.38206311
165drug transmembrane transport (GO:0006855)2.38077612
166L-methionine biosynthetic process (GO:0071265)2.37981331
167androgen biosynthetic process (GO:0006702)2.37598468
168regulation of cholesterol esterification (GO:0010872)2.37267865
169carnitine metabolic process (GO:0009437)2.37044138
170post-embryonic morphogenesis (GO:0009886)2.36624764
171GPI anchor metabolic process (GO:0006505)2.36209097
172nucleotide transport (GO:0006862)2.36049049
173opioid receptor signaling pathway (GO:0038003)2.35549431
174regulation of hexokinase activity (GO:1903299)2.35534522
175regulation of glucokinase activity (GO:0033131)2.35534522
176bile acid metabolic process (GO:0008206)2.35371319
177carboxylic acid catabolic process (GO:0046395)2.33671846
178organic acid catabolic process (GO:0016054)2.33671846
179monocarboxylic acid catabolic process (GO:0072329)2.33058513
180serine family amino acid biosynthetic process (GO:0009070)2.31996538
181lysine metabolic process (GO:0006553)2.31314388
182doxorubicin metabolic process (GO:0044598)11.7341820
183daunorubicin metabolic process (GO:0044597)11.7341820
184polyketide metabolic process (GO:0030638)11.7341820

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_23403033_ChIP-Seq_LIVER_Mouse4.47243105
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.11154485
3ZNF274_21170338_ChIP-Seq_K562_Hela3.59753440
4CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.29108497
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.26175125
6ELF1_17652178_ChIP-ChIP_JURKAT_Human3.15668643
7RXR_22158963_ChIP-Seq_LIVER_Mouse3.12148381
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.04385530
9PPARA_22158963_ChIP-Seq_LIVER_Mouse2.72775478
10IGF1R_20145208_ChIP-Seq_DFB_Human2.63000804
11EZH2_22144423_ChIP-Seq_EOC_Human2.61268291
12PCGF2_27294783_Chip-Seq_ESCs_Mouse2.48406191
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.40613651
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.35773721
15CTBP2_25329375_ChIP-Seq_LNCAP_Human2.35319953
16NOTCH1_21737748_ChIP-Seq_TLL_Human2.29772321
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.29229064
18LXR_22158963_ChIP-Seq_LIVER_Mouse2.29124744
19SUZ12_27294783_Chip-Seq_NPCs_Mouse2.27737191
20NFE2_27457419_Chip-Seq_LIVER_Mouse2.24170461
21TAF15_26573619_Chip-Seq_HEK293_Human2.20108947
22FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.18826831
23LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.17882725
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.16277858
25SRF_21415370_ChIP-Seq_HL-1_Mouse2.14628286
26FLI1_27457419_Chip-Seq_LIVER_Mouse2.14204825
27PCGF2_27294783_Chip-Seq_NPCs_Mouse2.09493064
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.09065193
29FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.06487612
30SALL1_21062744_ChIP-ChIP_HESCs_Human2.05423801
31CTBP1_25329375_ChIP-Seq_LNCAP_Human2.01956120
32JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.00904727
33FUS_26573619_Chip-Seq_HEK293_Human1.98665605
34NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.96969950
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.96888703
36RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.94919041
37AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.93501866
38GBX2_23144817_ChIP-Seq_PC3_Human1.91857016
39STAT3_23295773_ChIP-Seq_U87_Human1.90187766
40BP1_19119308_ChIP-ChIP_Hs578T_Human1.89509197
41EZH2_27294783_Chip-Seq_NPCs_Mouse1.86895491
42PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.78866955
43VDR_22108803_ChIP-Seq_LS180_Human1.70736452
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.69872832
45BCAT_22108803_ChIP-Seq_LS180_Human1.69572002
46TCF4_23295773_ChIP-Seq_U87_Human1.67284974
47PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.66481845
48GABP_17652178_ChIP-ChIP_JURKAT_Human1.66439096
49TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.66368074
50POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.66368074
51IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.65863974
52MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.65671365
53SMAD4_21799915_ChIP-Seq_A2780_Human1.63007038
54STAT3_18555785_Chip-Seq_ESCs_Mouse1.60133206
55EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.59031213
56FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.57515766
57NR3C1_21868756_ChIP-Seq_MCF10A_Human1.57257623
58UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.57130002
59RUNX1_27457419_Chip-Seq_LIVER_Mouse1.57070122
60CBP_20019798_ChIP-Seq_JUKART_Human1.56325355
61IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.56325355
62AR_21572438_ChIP-Seq_LNCaP_Human1.53863109
63SUZ12_18555785_Chip-Seq_ESCs_Mouse1.53855901
64P53_22387025_ChIP-Seq_ESCs_Mouse1.53151451
65LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.52977374
66ZFP57_27257070_Chip-Seq_ESCs_Mouse1.49589136
67HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.47086876
68BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.45973915
69IRF1_19129219_ChIP-ChIP_H3396_Human1.45705379
70ZFX_18555785_Chip-Seq_ESCs_Mouse1.43817792
71STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.42952987
72NMYC_18555785_Chip-Seq_ESCs_Mouse1.42257343
73OCT4_18555785_Chip-Seq_ESCs_Mouse1.41332182
74TP53_22573176_ChIP-Seq_HFKS_Human1.41233174
75EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.40914471
76AR_25329375_ChIP-Seq_VCAP_Human1.40632732
77FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.39483321
78KAP1_22055183_ChIP-Seq_ESCs_Mouse1.38265890
79PU1_27457419_Chip-Seq_LIVER_Mouse1.37312093
80PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.37012095
81* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36628872
82MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.36573819
83FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.35968124
84NANOG_18555785_Chip-Seq_ESCs_Mouse1.34284912
85TCF4_22108803_ChIP-Seq_LS180_Human1.33574332
86RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.33011224
87ESRRB_18555785_Chip-Seq_ESCs_Mouse1.32710817
88HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.32633946
89P300_18555785_Chip-Seq_ESCs_Mouse1.32215256
90MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.31924807
91AR_20517297_ChIP-Seq_VCAP_Human1.30452664
92SOX2_19829295_ChIP-Seq_ESCs_Human1.29617425
93NANOG_19829295_ChIP-Seq_ESCs_Human1.29617425
94PRDM14_20953172_ChIP-Seq_ESCs_Human1.29422514
95FOXP3_21729870_ChIP-Seq_TREG_Human1.29386017
96KLF4_18555785_Chip-Seq_ESCs_Mouse1.27354124
97KLF5_20875108_ChIP-Seq_MESCs_Mouse1.26266075
98TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26054432
99RUNX2_22187159_ChIP-Seq_PCA_Human1.25908620
100E2F1_18555785_Chip-Seq_ESCs_Mouse1.25900061
101CMYC_18555785_Chip-Seq_ESCs_Mouse1.25802026
102SOX2_18555785_Chip-Seq_ESCs_Mouse1.25264348
103TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.25195564
104* SMAD3_21741376_ChIP-Seq_EPCs_Human1.24863614
105SMAD1_18555785_Chip-Seq_ESCs_Mouse1.24612621
106MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.23518715
107GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.23195115
108ERG_20887958_ChIP-Seq_HPC-7_Mouse1.22800827
109E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.22510009
110CRX_20693478_ChIP-Seq_RETINA_Mouse1.21797723
111PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.21686477
112SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.21645557
113CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.21415948
114DROSHA_22980978_ChIP-Seq_HELA_Human1.21061225
115FOXA1_27270436_Chip-Seq_PROSTATE_Human1.20754578
116FOXA1_25329375_ChIP-Seq_VCAP_Human1.20754578
117FLI1_21867929_ChIP-Seq_TH2_Mouse1.20657097
118TP53_16413492_ChIP-PET_HCT116_Human1.20118934
119OCT4_21477851_ChIP-Seq_ESCs_Mouse1.18311814
120* REST_21632747_ChIP-Seq_MESCs_Mouse1.14378966
121FOXA1_21572438_ChIP-Seq_LNCaP_Human1.14364762
122* SMAD4_21741376_ChIP-Seq_EPCs_Human1.13525433
123GATA1_22025678_ChIP-Seq_K562_Human1.13232130
124POU3F2_20337985_ChIP-ChIP_501MEL_Human1.11555796
125CTCF_18555785_Chip-Seq_ESCs_Mouse1.11508133
126P300_19829295_ChIP-Seq_ESCs_Human1.10639036
127ER_23166858_ChIP-Seq_MCF-7_Human1.10457119
128ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.09468765
129TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09453359
130OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09164795
131SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08023928
132NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.07872277
133NCOR_22424771_ChIP-Seq_293T_Human1.07588390
134SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.06619128
135STAT1_17558387_ChIP-Seq_HELA_Human1.06176728
136CDX2_22108803_ChIP-Seq_LS180_Human1.05870919
137RXR_22108803_ChIP-Seq_LS180_Human1.04964787
138GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.04003699
139SOX2_21211035_ChIP-Seq_LN229_Gbm1.03934740
140* GATA3_21878914_ChIP-Seq_MCF-7_Human1.03064547
141HTT_18923047_ChIP-ChIP_STHdh_Human1.02871419
142EST1_17652178_ChIP-ChIP_JURKAT_Human1.01691495
143BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01331465
144RNF2_27304074_Chip-Seq_NSC_Mouse0.99143659
145KDM2B_26808549_Chip-Seq_REH_Human0.99006835
146* HOXB7_26014856_ChIP-Seq_BT474_Human0.98915958
147EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.98851877
148ARNT_22903824_ChIP-Seq_MCF-7_Human0.98815395
149ETV2_25802403_ChIP-Seq_MESCs_Mouse0.98340337
150TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98146273
151CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98055755
152TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.97808164
153SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.97789327
154GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.97604539
155MYC_18940864_ChIP-ChIP_HL60_Human0.97229862
156TAL1_26923725_Chip-Seq_HPCs_Mouse0.96187456
157* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.95493599
158EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.91122292
159BMI1_23680149_ChIP-Seq_NPCS_Mouse0.90448568
160PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.89696364
161* HNFA_21074721_ChIP-Seq_CACO-2_Human0.89191819
162HOXB4_20404135_ChIP-ChIP_EML_Mouse0.86525246
163VDR_23849224_ChIP-Seq_CD4+_Human0.86433679
164IRF8_27001747_Chip-Seq_BMDM_Mouse0.86204815
165DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.83088363
166SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.82148878
167MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.81708663
168EWS_26573619_Chip-Seq_HEK293_Human0.81422729

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.38778898
2MP0005365_abnormal_bile_salt4.37448564
3MP0000569_abnormal_digit_pigmentation3.74278485
4MP0005085_abnormal_gallbladder_physiolo3.46893115
5MP0009697_abnormal_copulation3.30016179
6MP0003191_abnormal_cellular_cholesterol3.15229870
7MP0005360_urolithiasis2.70428850
8MP0008877_abnormal_DNA_methylation2.64310981
9MP0005551_abnormal_eye_electrophysiolog2.57846387
10MP0005645_abnormal_hypothalamus_physiol2.48618742
11MP0003195_calcinosis2.46537945
12MP0003878_abnormal_ear_physiology2.43518042
13MP0005377_hearing/vestibular/ear_phenot2.43518042
14MP0000566_synostosis2.39995148
15MP0008004_abnormal_stomach_pH2.35970149
16MP0009046_muscle_twitch2.33634715
17MP0004147_increased_porphyrin_level2.30378625
18MP0001968_abnormal_touch/_nociception2.25223199
19MP0001501_abnormal_sleep_pattern2.25160918
20MP0005083_abnormal_biliary_tract2.20479449
21MP0005670_abnormal_white_adipose2.20453976
22MP0000372_irregular_coat_pigmentation2.13513521
23MP0002837_dystrophic_cardiac_calcinosis2.08059318
24MP0001986_abnormal_taste_sensitivity2.06601517
25MP0001666_abnormal_nutrient_absorption2.05213948
26MP0003252_abnormal_bile_duct1.97417074
27MP0005647_abnormal_sex_gland1.91924846
28MP0008875_abnormal_xenobiotic_pharmacok1.91040431
29MP0008872_abnormal_physiological_respon1.90872940
30MP0003868_abnormal_feces_composition1.90042427
31MP0006292_abnormal_olfactory_placode1.88606549
32MP0005174_abnormal_tail_pigmentation1.88348407
33MP0002132_abnormal_respiratory_system1.87859379
34MP0010329_abnormal_lipoprotein_level1.85021012
35MP0002735_abnormal_chemical_nociception1.78271828
36MP0005253_abnormal_eye_physiology1.76044726
37MP0002102_abnormal_ear_morphology1.75972235
38MP0002736_abnormal_nociception_after1.75410849
39MP0002138_abnormal_hepatobiliary_system1.72024547
40MP0009745_abnormal_behavioral_response1.71717865
41MP0001764_abnormal_homeostasis1.71687138
42MP0005220_abnormal_exocrine_pancreas1.69193624
43MP0004145_abnormal_muscle_electrophysio1.66250459
44MP0000427_abnormal_hair_cycle1.66181852
45MP0000678_abnormal_parathyroid_gland1.65437007
46MP0005332_abnormal_amino_acid1.63649807
47MP0005379_endocrine/exocrine_gland_phen1.62771562
48MP0004142_abnormal_muscle_tone1.62179922
49MP0005451_abnormal_body_composition1.58704994
50MP0006072_abnormal_retinal_apoptosis1.58198795
51MP0002277_abnormal_respiratory_mucosa1.57769159
52MP0004019_abnormal_vitamin_homeostasis1.55418417
53MP0000383_abnormal_hair_follicle1.55011914
54MP0004381_abnormal_hair_follicle1.49999714
55MP0003787_abnormal_imprinting1.49589339
56MP0001790_abnormal_immune_system1.46642393
57MP0005387_immune_system_phenotype1.46642393
58MP0002272_abnormal_nervous_system1.44641540
59MP0000631_abnormal_neuroendocrine_gland1.43551085
60MP0008058_abnormal_DNA_repair1.41058496
61MP0009840_abnormal_foam_cell1.39777034
62MP0005075_abnormal_melanosome_morpholog1.36406974
63MP0002928_abnormal_bile_duct1.34741616
64MP0003724_increased_susceptibility_to1.32971957
65MP0001486_abnormal_startle_reflex1.32636849
66MP0003879_abnormal_hair_cell1.30522573
67MP0008961_abnormal_basal_metabolism1.29183210
68MP0004782_abnormal_surfactant_physiolog1.29042939
69MP0008260_abnormal_autophagy1.28242367
70MP0000609_abnormal_liver_physiology1.25444299
71MP0002938_white_spotting1.25198808
72MP0002653_abnormal_ependyma_morphology1.24708490
73MP0003806_abnormal_nucleotide_metabolis1.22172198
74MP0002572_abnormal_emotion/affect_behav1.22160699
75MP0002876_abnormal_thyroid_physiology1.20697129
76MP0002118_abnormal_lipid_homeostasis1.19955426
77MP0002733_abnormal_thermal_nociception1.17778627
78MP0003763_abnormal_thymus_physiology1.17711565
79MP0003045_fibrosis1.17490354
80MP0009785_altered_susceptibility_to1.16692985
81MP0000685_abnormal_immune_system1.16198308
82MP0005319_abnormal_enzyme/_coenzyme1.15735255
83MP0002234_abnormal_pharynx_morphology1.15650768
84MP0001970_abnormal_pain_threshold1.15097365
85MP0005671_abnormal_response_to1.13091145
86MP0004885_abnormal_endolymph1.11483423
87MP0001835_abnormal_antigen_presentation1.11451905
88MP0005171_absent_coat_pigmentation1.10577669
89MP0003941_abnormal_skin_development1.10570831
90MP0002557_abnormal_social/conspecific_i1.10549791
91MP0003646_muscle_fatigue1.10340158
92MP0002064_seizures1.09021245
93MP0005386_behavior/neurological_phenoty1.07483982
94MP0004924_abnormal_behavior1.07483982
95MP0009643_abnormal_urine_homeostasis1.06183807
96MP0008995_early_reproductive_senescence1.06167518
97MP0004043_abnormal_pH_regulation1.06020551
98MP0002067_abnormal_sensory_capabilities1.05768604
99MP0002693_abnormal_pancreas_physiology1.05709589
100MP0005389_reproductive_system_phenotype1.05674249
101MP0009764_decreased_sensitivity_to1.04351687
102MP0008469_abnormal_protein_level1.03560299
103MP0004133_heterotaxia1.02675410
104MP0000230_abnormal_systemic_arterial1.02455102
105MP0004130_abnormal_muscle_cell1.02202849
106MP0002638_abnormal_pupillary_reflex1.00005999
107MP0003698_abnormal_male_reproductive0.99493486
108MP0005084_abnormal_gallbladder_morpholo0.98691716
109MP0002095_abnormal_skin_pigmentation0.98177054
110MP0005025_abnormal_response_to0.96411316
111MP0001984_abnormal_olfaction0.95738619
112MP0002160_abnormal_reproductive_system0.95501049
113MP0002419_abnormal_innate_immunity0.95357524
114MP0003183_abnormal_peptide_metabolism0.94979876
115MP0004742_abnormal_vestibular_system0.94815195
116MP0001664_abnormal_digestion0.94491780
117MP0005636_abnormal_mineral_homeostasis0.94119616
118MP0010094_abnormal_chromosome_stability0.92787194
119MP0001800_abnormal_humoral_immune0.92618314
120MP0005646_abnormal_pituitary_gland0.92380591
121MP0002148_abnormal_hypersensitivity_rea0.92298504
122MP0001485_abnormal_pinna_reflex0.91864621
123MP0001919_abnormal_reproductive_system0.91675199
124MP0008775_abnormal_heart_ventricle0.90997423
125MP0005266_abnormal_metabolism0.88845497
126MP0003890_abnormal_embryonic-extraembry0.88476252
127MP0002229_neurodegeneration0.88453506
128MP0003011_delayed_dark_adaptation0.88197881
129MP0002163_abnormal_gland_morphology0.87487408
130MP0001186_pigmentation_phenotype0.87083558
131MP0006276_abnormal_autonomic_nervous0.86308900
132MP0010386_abnormal_urinary_bladder0.86220954
133MP0001873_stomach_inflammation0.85770294
134MP0005167_abnormal_blood-brain_barrier0.85442678
135MP0000538_abnormal_urinary_bladder0.85389320
136MP0001929_abnormal_gametogenesis0.84841721
137MP0001346_abnormal_lacrimal_gland0.84464769
138MP0001324_abnormal_eye_pigmentation0.84344479
139MP0002078_abnormal_glucose_homeostasis0.84340909
140MP0004215_abnormal_myocardial_fiber0.83415457
141MP0005195_abnormal_posterior_eye0.83198954
142MP0002723_abnormal_immune_serum0.82509871
143MP0003950_abnormal_plasma_membrane0.82493288
144MP0003186_abnormal_redox_activity0.81863490
145MP0006082_CNS_inflammation0.81472778
146MP0002210_abnormal_sex_determination0.79007185
147MP0002063_abnormal_learning/memory/cond0.78084126
148MP0005448_abnormal_energy_balance0.78017936
149MP0003880_abnormal_central_pattern0.77755389
150MP0001188_hyperpigmentation0.77709996
151MP0003635_abnormal_synaptic_transmissio0.76717104
152MP0002168_other_aberrant_phenotype0.76447729
153MP0003959_abnormal_lean_body0.73465002
154MP0002396_abnormal_hematopoietic_system0.73305243
155MP0003718_maternal_effect0.73104155
156MP0001845_abnormal_inflammatory_respons0.72905263
157MP0005310_abnormal_salivary_gland0.71264515
158MP0008057_abnormal_DNA_replication0.71094575
159MP0003436_decreased_susceptibility_to0.71031702
160MP0009642_abnormal_blood_homeostasis0.71029444
161MP0000015_abnormal_ear_pigmentation0.71007422
162MP0002452_abnormal_antigen_presenting0.70659029
163MP0003172_abnormal_lysosome_physiology0.70504266
164MP0009763_increased_sensitivity_to0.68987363
165MP0001853_heart_inflammation0.68478623
166MP0002075_abnormal_coat/hair_pigmentati0.67373925
167MP0003136_yellow_coat_color0.67343618
168MP0005408_hypopigmentation0.66875531

Predicted human phenotypes

RankGene SetZ-score
1Parakeratosis (HP:0001036)5.88702089
2Pancreatic cysts (HP:0001737)4.62643651
3Pancreatic fibrosis (HP:0100732)4.10153691
4Genetic anticipation (HP:0003743)3.91109403
5Congenital stationary night blindness (HP:0007642)3.88623248
6Gaze-evoked nystagmus (HP:0000640)3.88228977
7True hermaphroditism (HP:0010459)3.79669979
8Molar tooth sign on MRI (HP:0002419)3.77576505
9Abnormality of midbrain morphology (HP:0002418)3.77576505
10Unilateral renal agenesis (HP:0000122)3.65283454
11Hyperventilation (HP:0002883)3.63915234
12Nephronophthisis (HP:0000090)3.59745628
13Conjugated hyperbilirubinemia (HP:0002908)3.54749104
14Renal cortical cysts (HP:0000803)3.46652920
15Attenuation of retinal blood vessels (HP:0007843)3.46069607
16Prolonged partial thromboplastin time (HP:0003645)3.41504678
17Type I transferrin isoform profile (HP:0003642)3.39302913
18Abnormality of aromatic amino acid family metabolism (HP:0004338)3.36767063
19Abnormality of the renal medulla (HP:0100957)3.29282667
20Progressive cerebellar ataxia (HP:0002073)3.22051203
21Generalized aminoaciduria (HP:0002909)3.18251882
22Large for gestational age (HP:0001520)3.07365064
23Hypoglycemic seizures (HP:0002173)3.05079642
24Hypoglycemic coma (HP:0001325)3.02418078
25Clumsiness (HP:0002312)2.99856003
26Cystic liver disease (HP:0006706)2.95147684
27Type II lissencephaly (HP:0007260)2.94398148
28Abnormality of pyrimidine metabolism (HP:0004353)2.87068976
293-Methylglutaconic aciduria (HP:0003535)2.86671478
30Chromosomal breakage induced by crosslinking agents (HP:0003221)2.86081888
31Symptomatic seizures (HP:0011145)2.85818729
32Microvesicular hepatic steatosis (HP:0001414)2.84720699
33Protruding tongue (HP:0010808)2.84597362
34Reduced antithrombin III activity (HP:0001976)2.84252738
35Cheilitis (HP:0100825)2.83441749
36Abnormal glycosylation (HP:0012345)2.81375011
37Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.81375011
38Abnormal protein N-linked glycosylation (HP:0012347)2.81375011
39Abnormal protein glycosylation (HP:0012346)2.81375011
40Joint hemorrhage (HP:0005261)2.79956784
41Medial flaring of the eyebrow (HP:0010747)2.76852998
42Absent eyelashes (HP:0000561)2.75020893
43Alopecia of scalp (HP:0002293)2.74657723
44Bilateral sensorineural hearing impairment (HP:0008619)2.73674784
45Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.73306637
46Abnormality of alanine metabolism (HP:0010916)2.73306637
47Hyperalaninemia (HP:0003348)2.73306637
48Tubular atrophy (HP:0000092)2.71925751
49Osteomalacia (HP:0002749)2.70541986
50Hepatic necrosis (HP:0002605)2.68791556
51Chronic otitis media (HP:0000389)2.65466446
52Birth length less than 3rd percentile (HP:0003561)2.65358867
53Dicarboxylic aciduria (HP:0003215)2.64177974
54Abnormality of dicarboxylic acid metabolism (HP:0010995)2.64177974
55Broad-based gait (HP:0002136)2.60447952
56Inability to walk (HP:0002540)2.60246629
57Duplicated collecting system (HP:0000081)2.59117248
58Aplasia/Hypoplasia of the tibia (HP:0005772)2.58033888
59Abnormality of fatty-acid metabolism (HP:0004359)2.56458140
60Intrahepatic cholestasis (HP:0001406)2.55213167
61Hyperglycinemia (HP:0002154)2.53575024
62Fair hair (HP:0002286)2.52947494
63Abnormality of methionine metabolism (HP:0010901)2.52755673
64Proximal tubulopathy (HP:0000114)2.51525892
65Abnormal drinking behavior (HP:0030082)2.50898670
66Polydipsia (HP:0001959)2.50898670
67Progressive inability to walk (HP:0002505)2.50678142
68Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.49711395
69Recurrent corneal erosions (HP:0000495)2.47252213
70Abolished electroretinogram (ERG) (HP:0000550)2.46061234
71Increased neuronal autofluorescent lipopigment (HP:0002074)2.44667229
72Tetany (HP:0001281)2.44476164
73Cerebellar dysplasia (HP:0007033)2.43147948
74Abnormality of monocarboxylic acid metabolism (HP:0010996)2.42618505
75Abnormality of dental color (HP:0011073)2.42129819
76Absent eyebrow (HP:0002223)2.41608608
77Chronic hepatic failure (HP:0100626)2.40565718
78Renal Fanconi syndrome (HP:0001994)2.39962643
79Abnormality of the renal collecting system (HP:0004742)2.38403810
80Congenital hepatic fibrosis (HP:0002612)2.38279570
81Abnormality of the renal cortex (HP:0011035)2.36801124
82Chromsome breakage (HP:0040012)2.36529597
83Bony spicule pigmentary retinopathy (HP:0007737)2.35220016
84Ketosis (HP:0001946)2.34258785
85Abnormality of aspartate family amino acid metabolism (HP:0010899)2.33046828
86Sclerocornea (HP:0000647)2.29397745
87Amniotic constriction ring (HP:0009775)2.29321370
88Abnormality of placental membranes (HP:0011409)2.29321370
89Decreased circulating renin level (HP:0003351)2.29170754
90Hyperphosphatemia (HP:0002905)2.28516281
91Furrowed tongue (HP:0000221)2.27492798
92Glycosuria (HP:0003076)2.27271479
93Abnormality of urine glucose concentration (HP:0011016)2.27271479
94Dynein arm defect of respiratory motile cilia (HP:0012255)2.27106752
95Absent/shortened dynein arms (HP:0200106)2.27106752
96Vascular calcification (HP:0004934)2.26170585
97Abnormality of renal resorption (HP:0011038)2.25937396
98Patellar aplasia (HP:0006443)2.25649495
99Hyperammonemia (HP:0001987)2.23722254
100Abnormality of serine family amino acid metabolism (HP:0010894)2.23276338
101Abnormality of glycine metabolism (HP:0010895)2.23276338
102Opisthotonus (HP:0002179)2.23084605
103Keratoconus (HP:0000563)2.22371242
104Increased corneal curvature (HP:0100692)2.22371242
105Abnormal biliary tract physiology (HP:0012439)2.21433830
106Bile duct proliferation (HP:0001408)2.21433830
107Follicular hyperkeratosis (HP:0007502)2.21423737
108Abnormality of the intrinsic pathway (HP:0010989)2.18657665
109Febrile seizures (HP:0002373)2.17720042
110Congenital sensorineural hearing impairment (HP:0008527)2.17538232
111Aplasia/Hypoplasia of the tongue (HP:0010295)2.16686322
112Hyperlipoproteinemia (HP:0010980)2.15118557
113Pendular nystagmus (HP:0012043)2.14521173
114Hyperglycinuria (HP:0003108)2.14215529
115Decreased electroretinogram (ERG) amplitude (HP:0000654)2.14156111
116Hepatocellular necrosis (HP:0001404)2.14079142
117Ketoacidosis (HP:0001993)2.13427738
118Aplasia/Hypoplasia of the patella (HP:0006498)2.12506606
119Absent speech (HP:0001344)2.11630693
120Dialeptic seizures (HP:0011146)2.09894423
121Stomach cancer (HP:0012126)2.09526463
122Lissencephaly (HP:0001339)2.09085042
123Hypoplasia of the pons (HP:0012110)2.08206772
124Decreased central vision (HP:0007663)2.07518520
125Methylmalonic acidemia (HP:0002912)2.07357816
126Hyperinsulinemic hypoglycemia (HP:0000825)2.06849217
127Abnormality of the pons (HP:0007361)2.06813920
128Gait imbalance (HP:0002141)2.06074480
129Congenital primary aphakia (HP:0007707)2.05932690
130Hypergonadotropic hypogonadism (HP:0000815)2.05851402
131Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.05675322
132Abnormal rod and cone electroretinograms (HP:0008323)2.04909969
133Tubulointerstitial nephritis (HP:0001970)2.03660817
134Anencephaly (HP:0002323)2.03500771
135Lipid accumulation in hepatocytes (HP:0006561)2.02917669
136Aplasia/Hypoplasia of the uvula (HP:0010293)2.02881118
137Postaxial foot polydactyly (HP:0001830)2.02770962
138Widely spaced teeth (HP:0000687)2.02066748
139Generalized hypopigmentation of hair (HP:0011358)2.01917033
140Abnormality of nucleobase metabolism (HP:0010932)1.98759732
141Abnormality of sulfur amino acid metabolism (HP:0004339)1.97885655
142Increased hepatocellular lipid droplets (HP:0006565)1.96784095
143Polyuria (HP:0000103)1.95858488
144Fat malabsorption (HP:0002630)1.95220787
145Metabolic acidosis (HP:0001942)1.93708263
146Ectropion (HP:0000656)1.93469546
147Abnormality of serum amino acid levels (HP:0003112)1.93241415
148Clubbing of toes (HP:0100760)1.93056159
149Type 2 muscle fiber atrophy (HP:0003554)1.92462523
150Small hand (HP:0200055)1.92179564
151Erythroderma (HP:0001019)1.92103763
152Focal seizures (HP:0007359)1.91341477
153Chronic sinusitis (HP:0011109)1.90740675
154Methylmalonic aciduria (HP:0012120)1.90489116
155Severe muscular hypotonia (HP:0006829)1.90427411
156Complement deficiency (HP:0004431)1.90175331
157Patchy hypopigmentation of hair (HP:0011365)1.89799348
158Nephrogenic diabetes insipidus (HP:0009806)1.88992782
159Absent rod-and cone-mediated responses on ERG (HP:0007688)1.88054625
160Cardiovascular calcification (HP:0011915)1.86445671
161Male pseudohermaphroditism (HP:0000037)1.86167874
162Hemiparesis (HP:0001269)1.86128755
163Alveolar cell carcinoma (HP:0006519)1.84561955
164Hypobetalipoproteinemia (HP:0003563)1.84064738
165Xanthomatosis (HP:0000991)1.83843941
166Systemic lupus erythematosus (HP:0002725)1.83830823
167Steatorrhea (HP:0002570)1.83052207
168Chorioretinal atrophy (HP:0000533)1.81870806
169Hypothermia (HP:0002045)1.81344355
170Genital tract atresia (HP:0001827)1.80650384
171Focal motor seizures (HP:0011153)1.80582188
172Lethargy (HP:0001254)1.80460331
173Constricted visual fields (HP:0001133)1.80207230
174Glomerulonephritis (HP:0000099)1.79870810
175Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.79241801
176White forelock (HP:0002211)1.77487944
177Sloping forehead (HP:0000340)1.73120566
178Poor coordination (HP:0002370)1.71210234
179Vaginal atresia (HP:0000148)1.70796227
180Retinitis pigmentosa (HP:0000510)1.69704350
181Preaxial hand polydactyly (HP:0001177)1.69126948
182Abnormality of the ileum (HP:0001549)1.68104296
183Ectopic kidney (HP:0000086)1.65445149
184Intestinal atresia (HP:0011100)1.64639931
185Highly arched eyebrow (HP:0002553)1.63400226

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK34.63734237
2STK163.28002713
3ACVR1B3.23151393
4BCKDK2.84537480
5INSRR2.81659755
6SIK12.75557668
7TXK2.61023357
8IRAK32.52951934
9MUSK2.51458271
10IRAK42.45374201
11SRPK12.12297878
12SIK22.05056469
13STK38L1.98048820
14CASK1.96211889
15MAP3K141.95763315
16MAP4K21.95569195
17WNK31.94870328
18ZAK1.94253068
19ADRBK21.82368294
20MKNK11.81947206
21TAOK31.81117370
22NLK1.79151296
23EPHA21.75127330
24IRAK11.64787912
25PINK11.63090523
26MAPK151.56627447
27BMPR1B1.55586832
28VRK11.47238866
29ZAP701.45769818
30TYK21.43573192
31PIK3CG1.42895055
32TEC1.39403586
33JAK31.33313200
34PLK41.32334720
35DAPK21.31124528
36ADRBK11.26298430
37IRAK21.25310667
38STK391.25028933
39TNIK1.24782413
40MAP4K11.23226667
41MAP3K41.21308969
42TGFBR11.20258398
43CDK81.19797825
44EPHA31.19025681
45TIE11.14581094
46FLT31.11106835
47BRD41.10704823
48FGFR41.08696252
49BTK1.06841504
50KIT1.05211514
51TRIM281.04530892
52IKBKB1.04297133
53NTRK31.03974952
54TLK11.03331468
55MARK31.02860008
56BLK1.00693433
57GRK10.97953176
58CAMK1D0.97343666
59PRPF4B0.97168197
60PIK3CA0.93909264
61CAMKK20.93407550
62IKBKE0.92521408
63EIF2AK20.92430139
64SGK20.90804104
65CAMK1G0.89748217
66MAPK130.88973276
67NME20.87356765
68TNK20.82915215
69MAPKAPK30.82449148
70PRKCE0.81087213
71FER0.79643906
72FRK0.78423829
73PAK30.78287243
74AKT30.77140363
75BRSK20.75118744
76LATS10.73965156
77TAOK20.72366659
78PASK0.72305101
79PRKCG0.71846241
80FGFR20.71379960
81SYK0.71227171
82LYN0.69575730
83STK240.68436178
84JAK10.66098565
85MAP2K70.65771909
86PTK2B0.64567857
87TRPM70.63676311
88OBSCN0.61773600
89NUAK10.61023519
90YES10.60907368
91CHEK20.60591359
92CDK30.60156063
93PNCK0.60041241
94GRK70.59298037
95CAMK10.59107221
96STK30.57659757
97MAP3K70.55826845
98WNK40.54089953
99PRKD30.53312954
100CSNK1A1L0.52148546
101MYLK0.50849360
102ITK0.49971732
103LCK0.49473713
104EIF2AK10.48729969
105BRAF0.48167355
106MAPK110.47655378
107PRKCQ0.47071074
108PRKAA10.46741656
109NEK20.46635660
110PKN10.45297496
111MAPK70.45069954
112MAPKAPK50.44653981
113SGK4940.44557686
114SGK2230.44557686
115TGFBR20.44529238
116KDR0.44145924
117OXSR10.43592947
118PIM20.42359815
119CAMK2A0.42196747
120MKNK20.42137709
121STK110.41680209
122EIF2AK30.41000210
123ERN10.40637666
124PLK20.39992683
125PRKAA20.39853177
126MAP3K120.39804662
127DYRK1A0.39745810
128PHKG10.39200712
129PHKG20.39200712
130NEK60.38848073
131BMPR20.38482578
132PRKCH0.38096721
133CSNK2A10.37506809
134RPS6KA50.37056021
135CDK70.36495317
136NEK90.36328517
137ATM0.36237643
138ATR0.35962309
139CHUK0.35193137
140PRKACA0.34785142
141CSNK1A10.34594258
142CAMK40.33510399
143NME10.33395126
144CSNK1D0.32679000
145CSNK1G20.31916328
146HIPK20.31342562
147SGK30.31108710
148MAP2K60.30815292
149CDC70.30722392
150PRKD20.30326121
151MAP2K10.29878316
152STK380.29846049
153MELK0.28763842
154HCK0.28733522
155CSNK1G10.28717734
156CCNB10.27197944
157MARK10.27143691
158PRKACB0.26675944

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030602.91591937
2Maturity onset diabetes of the young_Homo sapiens_hsa049502.84415815
3Phototransduction_Homo sapiens_hsa047442.80298635
4Nitrogen metabolism_Homo sapiens_hsa009102.49229519
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.48540770
6Primary bile acid biosynthesis_Homo sapiens_hsa001202.37983716
7Peroxisome_Homo sapiens_hsa041462.28831936
8Fatty acid elongation_Homo sapiens_hsa000622.27764534
9Tryptophan metabolism_Homo sapiens_hsa003802.27254411
10Fatty acid degradation_Homo sapiens_hsa000712.16746496
11Nicotine addiction_Homo sapiens_hsa050332.05681335
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.03673942
13Steroid hormone biosynthesis_Homo sapiens_hsa001402.01465793
14Steroid biosynthesis_Homo sapiens_hsa001002.01425870
15Propanoate metabolism_Homo sapiens_hsa006401.97108711
16Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.93579921
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.93451422
18Taste transduction_Homo sapiens_hsa047421.83435453
19Folate biosynthesis_Homo sapiens_hsa007901.83353495
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.82267025
21Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.79007227
22Ether lipid metabolism_Homo sapiens_hsa005651.75817286
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.74027619
24Pentose and glucuronate interconversions_Homo sapiens_hsa000401.70568831
25ABC transporters_Homo sapiens_hsa020101.63874696
26Fatty acid metabolism_Homo sapiens_hsa012121.56659595
27Butanoate metabolism_Homo sapiens_hsa006501.56289742
28Complement and coagulation cascades_Homo sapiens_hsa046101.55164837
29Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.55122056
30Olfactory transduction_Homo sapiens_hsa047401.54705569
31Selenocompound metabolism_Homo sapiens_hsa004501.53681834
32Caffeine metabolism_Homo sapiens_hsa002321.53070270
33Retinol metabolism_Homo sapiens_hsa008301.51924012
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.51007136
35One carbon pool by folate_Homo sapiens_hsa006701.48308269
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.47463026
37beta-Alanine metabolism_Homo sapiens_hsa004101.47356409
38Sulfur metabolism_Homo sapiens_hsa009201.44826826
39Vitamin digestion and absorption_Homo sapiens_hsa049771.44759474
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.43127174
41Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.40767047
42Staphylococcus aureus infection_Homo sapiens_hsa051501.40512223
43Morphine addiction_Homo sapiens_hsa050321.37758266
44Histidine metabolism_Homo sapiens_hsa003401.36125897
45Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.35969880
46Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.35418804
47Primary immunodeficiency_Homo sapiens_hsa053401.33506097
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.32838393
49Drug metabolism - other enzymes_Homo sapiens_hsa009831.28656707
50Chemical carcinogenesis_Homo sapiens_hsa052041.27978472
51Other glycan degradation_Homo sapiens_hsa005111.26456304
52PPAR signaling pathway_Homo sapiens_hsa033201.23442258
53Sulfur relay system_Homo sapiens_hsa041221.21224564
54Starch and sucrose metabolism_Homo sapiens_hsa005001.20796934
55Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.19439129
56Vitamin B6 metabolism_Homo sapiens_hsa007501.18782812
57NF-kappa B signaling pathway_Homo sapiens_hsa040641.14519847
58Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.08772904
59SNARE interactions in vesicular transport_Homo sapiens_hsa041301.08325617
60Cyanoamino acid metabolism_Homo sapiens_hsa004601.06823379
61Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.06647561
62Circadian entrainment_Homo sapiens_hsa047131.04810017
63Calcium signaling pathway_Homo sapiens_hsa040201.04332738
64Arginine and proline metabolism_Homo sapiens_hsa003301.04069376
65Glutamatergic synapse_Homo sapiens_hsa047241.03702750
66Arginine biosynthesis_Homo sapiens_hsa002201.00924076
67Homologous recombination_Homo sapiens_hsa034401.00719671
68Serotonergic synapse_Homo sapiens_hsa047260.99883547
69Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.97997872
70Fanconi anemia pathway_Homo sapiens_hsa034600.96379322
71Proteasome_Homo sapiens_hsa030500.96068751
72Insulin secretion_Homo sapiens_hsa049110.95280529
73Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.91952926
74Lysine degradation_Homo sapiens_hsa003100.91852149
75Arachidonic acid metabolism_Homo sapiens_hsa005900.89675363
76Salivary secretion_Homo sapiens_hsa049700.89138128
77Metabolic pathways_Homo sapiens_hsa011000.88043029
78GABAergic synapse_Homo sapiens_hsa047270.87805302
79Asthma_Homo sapiens_hsa053100.87373533
80Linoleic acid metabolism_Homo sapiens_hsa005910.87346094
81alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.86312122
82RNA degradation_Homo sapiens_hsa030180.84037664
83Tyrosine metabolism_Homo sapiens_hsa003500.83749803
84Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.82622737
85Dorso-ventral axis formation_Homo sapiens_hsa043200.81098720
86Sphingolipid metabolism_Homo sapiens_hsa006000.79239179
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.76899066
88Intestinal immune network for IgA production_Homo sapiens_hsa046720.76040836
89Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.75474249
90Phenylalanine metabolism_Homo sapiens_hsa003600.74859567
91N-Glycan biosynthesis_Homo sapiens_hsa005100.74113417
92Autoimmune thyroid disease_Homo sapiens_hsa053200.72026120
93Oxidative phosphorylation_Homo sapiens_hsa001900.71841633
94Pyrimidine metabolism_Homo sapiens_hsa002400.71466011
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70618024
96Pyruvate metabolism_Homo sapiens_hsa006200.69357996
97Glycerophospholipid metabolism_Homo sapiens_hsa005640.68823149
98* Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.64540690
99Glycosaminoglycan degradation_Homo sapiens_hsa005310.64263002
100Hematopoietic cell lineage_Homo sapiens_hsa046400.63737933
101RNA polymerase_Homo sapiens_hsa030200.63544527
102Regulation of autophagy_Homo sapiens_hsa041400.62915032
103Basal transcription factors_Homo sapiens_hsa030220.61903976
104Long-term depression_Homo sapiens_hsa047300.61649703
105Measles_Homo sapiens_hsa051620.59695929
106Toll-like receptor signaling pathway_Homo sapiens_hsa046200.59174369
107Graft-versus-host disease_Homo sapiens_hsa053320.56807184
108Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.56448871
109Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.56351505
110RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.54114574
111Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54091349
112Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.52578091
113Glycerolipid metabolism_Homo sapiens_hsa005610.50120067
114Glutathione metabolism_Homo sapiens_hsa004800.50036183
115Fatty acid biosynthesis_Homo sapiens_hsa000610.49078739
116Cysteine and methionine metabolism_Homo sapiens_hsa002700.49039963
117Cholinergic synapse_Homo sapiens_hsa047250.48880835
118Fat digestion and absorption_Homo sapiens_hsa049750.47435893
119Allograft rejection_Homo sapiens_hsa053300.47317670
120Purine metabolism_Homo sapiens_hsa002300.47020141
121Non-homologous end-joining_Homo sapiens_hsa034500.46527604
122Pancreatic secretion_Homo sapiens_hsa049720.46185017
123Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.45667313
124Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.44865637
125Oxytocin signaling pathway_Homo sapiens_hsa049210.44184082
126Base excision repair_Homo sapiens_hsa034100.43979665
127Dopaminergic synapse_Homo sapiens_hsa047280.40370617
128Pentose phosphate pathway_Homo sapiens_hsa000300.40065854
129Type I diabetes mellitus_Homo sapiens_hsa049400.38738665
130Circadian rhythm_Homo sapiens_hsa047100.37733087
131Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.37652048
132cAMP signaling pathway_Homo sapiens_hsa040240.37261056
133Type II diabetes mellitus_Homo sapiens_hsa049300.35414158
134Gastric acid secretion_Homo sapiens_hsa049710.35263839
135Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.34052955
136Ovarian steroidogenesis_Homo sapiens_hsa049130.33501792
137Herpes simplex infection_Homo sapiens_hsa051680.33267853
138Aldosterone synthesis and secretion_Homo sapiens_hsa049250.32746540
139DNA replication_Homo sapiens_hsa030300.31608442
140Nucleotide excision repair_Homo sapiens_hsa034200.29436986
141Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.27618346

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