CYBA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Cytochrome b is comprised of a light chain (alpha) and a heavy chain (beta). This gene encodes the light, alpha subunit which has been proposed as a primary component of the microbicidal oxidase system of phagocytes. Mutations in this gene are associated with autosomal recessive chronic granulomatous disease (CGD), that is characterized by the failure of activated phagocytes to generate superoxide, which is important for the microbicidal activity of these cells. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.30498575
2neutrophil activation involved in immune response (GO:0002283)6.10948904
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.02738353
4positive regulation by organism of defense response of other organism involved in symbiotic interact5.02738353
5modulation by symbiont of host immune response (GO:0052553)5.02738353
6positive regulation by symbiont of host defense response (GO:0052509)5.02738353
7modulation by symbiont of host defense response (GO:0052031)5.02738353
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.02738353
9response to peptidoglycan (GO:0032494)4.94308713
10negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.83434808
11negative regulation of cell killing (GO:0031342)4.83434808
12immunoglobulin mediated immune response (GO:0016064)4.63311414
13granulocyte activation (GO:0036230)4.40688927
14detection of other organism (GO:0098543)4.30433080
15detection of bacterium (GO:0016045)4.27517935
16neutrophil activation (GO:0042119)4.27317882
17positive regulation of interferon-alpha production (GO:0032727)4.25085866
18* respiratory burst (GO:0045730)4.22227241
19macrophage activation involved in immune response (GO:0002281)4.12280812
20leukocyte aggregation (GO:0070486)4.03119089
21regulation of interferon-alpha production (GO:0032647)4.02061675
22antigen processing and presentation of endogenous antigen (GO:0019883)3.97892393
23regulation of interferon-beta biosynthetic process (GO:0045357)3.94497978
24lipopolysaccharide-mediated signaling pathway (GO:0031663)3.87659456
25positive regulation of antigen processing and presentation (GO:0002579)3.82783059
26production of molecular mediator involved in inflammatory response (GO:0002532)3.77231778
27positive regulation of chemokine biosynthetic process (GO:0045080)3.70322391
28antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.70252996
29antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.70252996
30positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.69651927
31positive regulation of gamma-delta T cell activation (GO:0046645)3.68744573
32myeloid cell activation involved in immune response (GO:0002275)3.68157873
33cellular response to zinc ion (GO:0071294)3.67852217
34regulation of gamma-delta T cell activation (GO:0046643)3.67794031
35regulation of B cell receptor signaling pathway (GO:0050855)3.66512826
36B cell mediated immunity (GO:0019724)3.61768258
37detection of external biotic stimulus (GO:0098581)3.56468807
38positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.55045162
39negative regulation of erythrocyte differentiation (GO:0045647)3.51116146
40response to muramyl dipeptide (GO:0032495)3.48422096
41response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.46845696
42response to host immune response (GO:0052572)3.46845696
43defense response to protozoan (GO:0042832)3.45553810
44positive regulation of B cell differentiation (GO:0045579)3.43503430
45type I interferon signaling pathway (GO:0060337)3.42923044
46cellular response to type I interferon (GO:0071357)3.42923044
47positive regulation of mast cell activation (GO:0033005)3.42521254
48regulation of myeloid leukocyte mediated immunity (GO:0002886)3.41630378
49response to type I interferon (GO:0034340)3.40220751
50cellular response to interferon-beta (GO:0035458)3.39921064
51regulation of dendritic cell antigen processing and presentation (GO:0002604)3.36976836
52regulation of leukocyte degranulation (GO:0043300)3.36094459
53positive thymic T cell selection (GO:0045059)3.35621360
54positive regulation of mast cell activation involved in immune response (GO:0033008)3.35209435
55positive regulation of mast cell degranulation (GO:0043306)3.35209435
56natural killer cell mediated cytotoxicity (GO:0042267)3.34944213
57natural killer cell mediated immunity (GO:0002228)3.34944213
58regulation of antigen processing and presentation (GO:0002577)3.34779788
59myeloid dendritic cell differentiation (GO:0043011)3.32743841
60Arp2/3 complex-mediated actin nucleation (GO:0034314)3.31704638
61regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.31703920
62interferon-gamma-mediated signaling pathway (GO:0060333)3.31296062
63regulation of chemokine biosynthetic process (GO:0045073)3.29616255
64myeloid dendritic cell activation (GO:0001773)3.28930620
65cellular extravasation (GO:0045123)3.24451544
66leukocyte mediated cytotoxicity (GO:0001909)3.23980274
67B cell receptor signaling pathway (GO:0050853)3.23595325
68T cell migration (GO:0072678)3.22074923
69positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.21283876
70regulation of mast cell degranulation (GO:0043304)3.21101729
71regulation of gamma-delta T cell differentiation (GO:0045586)3.18655853
72negative regulation of myeloid cell apoptotic process (GO:0033033)3.18344460
73regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.18201643
74response to protozoan (GO:0001562)3.14892713
75detection of biotic stimulus (GO:0009595)3.13532208
76positive regulation of interferon-beta production (GO:0032728)3.12875703
77* superoxide anion generation (GO:0042554)3.12832077
78regulation of T-helper 1 cell differentiation (GO:0045625)3.12741000
79germinal center formation (GO:0002467)3.10563031
80response to interferon-beta (GO:0035456)3.09184429
81response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.08821485
82response to host (GO:0075136)3.08821485
83response to host defenses (GO:0052200)3.08821485
84regulation of mast cell activation (GO:0033003)3.07126861
85negative regulation of cytokine production involved in immune response (GO:0002719)3.04533787
86positive regulation of monocyte chemotaxis (GO:0090026)3.03454682
87regulation of mononuclear cell migration (GO:0071675)3.02859231
88regulation of T cell tolerance induction (GO:0002664)3.02742172
89negative regulation of lymphocyte mediated immunity (GO:0002707)3.02728228
90regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.02574964
91positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.02357176
92negative regulation of leukocyte mediated immunity (GO:0002704)3.01713818
93macrophage activation (GO:0042116)3.00573678
94myeloid leukocyte activation (GO:0002274)3.00003101
95eosinophil chemotaxis (GO:0048245)2.98465223
96lymphocyte chemotaxis (GO:0048247)2.98219935
97regulation of interleukin-12 biosynthetic process (GO:0045075)2.97734545
98regulation of mast cell activation involved in immune response (GO:0033006)2.97259355
99NIK/NF-kappaB signaling (GO:0038061)2.97165606
100positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.95811400
101regulation of B cell differentiation (GO:0045577)2.94185633
102leukocyte cell-cell adhesion (GO:0007159)2.92667599
103positive regulation of interleukin-12 production (GO:0032735)2.92385394
104positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.91014541
105mast cell activation (GO:0045576)2.90801180
106negative regulation of interleukin-12 production (GO:0032695)2.90545855
107detection of molecule of bacterial origin (GO:0032490)2.90329615
108negative regulation of phagocytosis (GO:0050765)2.90178022
109microglial cell activation (GO:0001774)2.88089878
110positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.87829117
111mature B cell differentiation involved in immune response (GO:0002313)2.87691224
112monocyte chemotaxis (GO:0002548)2.87621941
113regulation of tolerance induction (GO:0002643)2.86984119
114* hydrogen peroxide biosynthetic process (GO:0050665)2.86518739
115positive regulation of cellular amide metabolic process (GO:0034250)2.85210540
116positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.84743199
117lymphocyte mediated immunity (GO:0002449)2.84591321
118neutrophil chemotaxis (GO:0030593)2.84309789
119cellular response to exogenous dsRNA (GO:0071360)2.84183555
120negative regulation of interleukin-17 production (GO:0032700)2.83729597
121regulation of T-helper 2 cell differentiation (GO:0045628)2.83514607
122eosinophil migration (GO:0072677)2.83335463
123dendritic cell differentiation (GO:0097028)2.82490534
124positive regulation of tumor necrosis factor production (GO:0032760)2.82020786
125neutrophil migration (GO:1990266)2.80578646
126T-helper 1 type immune response (GO:0042088)2.78011715
127negative regulation of innate immune response (GO:0045824)2.77942415
128amino sugar catabolic process (GO:0046348)2.76742872
129regulation of superoxide anion generation (GO:0032928)2.74905950
130negative thymic T cell selection (GO:0045060)2.73711585
131negative regulation of T cell mediated immunity (GO:0002710)2.72533960
132regulation of regulated secretory pathway (GO:1903305)2.70869229
133T cell selection (GO:0045058)2.67691373
134positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.67666300
135negative regulation of interleukin-6 production (GO:0032715)2.67663601
136leukocyte degranulation (GO:0043299)2.67353040
137neutrophil mediated immunity (GO:0002446)2.66214611

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse6.61647220
2IRF8_22096565_ChIP-ChIP_GC-B_Human6.55982426
3BP1_19119308_ChIP-ChIP_Hs578T_Human6.33911225
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.30641095
5IRF8_27001747_Chip-Seq_BMDM_Mouse4.05342467
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.78351207
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.64045461
8* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.48578227
9NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.45758661
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.45247325
11SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.15700340
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.08846017
13MYB_21317192_ChIP-Seq_ERMYB_Mouse3.07837356
14Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.01939396
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.83197422
16* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.79224167
17* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.78824070
18STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.66216509
19NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.54122102
20* SPI1_23547873_ChIP-Seq_NB4_Human2.41371262
21BRD4_27068464_Chip-Seq_AML-cells_Mouse2.20948471
22LXR_22292898_ChIP-Seq_THP-1_Human2.19001446
23RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.12376072
24KDM2B_26808549_Chip-Seq_SUP-B15_Human2.09160064
25MYB_26560356_Chip-Seq_TH2_Human2.00275123
26* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.92287033
27VDR_24763502_ChIP-Seq_THP-1_Human1.92208218
28RUNX1_22412390_ChIP-Seq_EML_Mouse1.86383963
29ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.82135765
30FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.81039152
31KDM2B_26808549_Chip-Seq_DND41_Human1.80476979
32MAF_26560356_Chip-Seq_TH1_Human1.78256087
33CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.77762710
34PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.74972685
35CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.73983923
36TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73947536
37STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.73470384
38NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.70309128
39RUNX_20019798_ChIP-Seq_JUKART_Human1.67296761
40PU_27001747_Chip-Seq_BMDM_Mouse1.64619157
41* VDR_21846776_ChIP-Seq_THP-1_Human1.63894814
42FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.60892708
43SCL_19346495_ChIP-Seq_HPC-7_Human1.60519203
44MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.60183647
45MYB_26560356_Chip-Seq_TH1_Human1.58925373
46SPI1_23127762_ChIP-Seq_K562_Human1.55291612
47KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.45161467
48THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.44478540
49CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.42802731
50CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.42090880
51LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.41643250
52VDR_24787735_ChIP-Seq_THP-1_Human1.40602977
53BCOR_27268052_Chip-Seq_Bcells_Human1.38559980
54UTX_26944678_Chip-Seq_JUKART_Human1.34314853
55ELF1_20517297_ChIP-Seq_JURKAT_Human1.33521094
56PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32534944
57PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.30961995
58RACK7_27058665_Chip-Seq_MCF-7_Human1.30853225
59E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.30542095
60SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29299520
61PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.27129565
62PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.27063365
63GATA2_22383799_ChIP-Seq_G1ME_Mouse1.24939414
64GATA3_27048872_Chip-Seq_THYMUS_Human1.23274206
65P68_20966046_ChIP-Seq_HELA_Human1.22779808
66CTCF_27219007_Chip-Seq_ERYTHROID_Human1.20108607
67GATA3_26560356_Chip-Seq_TH2_Human1.18534362
68LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.18214686
69SA1_27219007_Chip-Seq_ERYTHROID_Human1.18092811
70NCOR1_26117541_ChIP-Seq_K562_Human1.17662466
71E2F7_22180533_ChIP-Seq_HELA_Human1.17412769
72GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.16235599
73SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.14503743
74STAT6_21828071_ChIP-Seq_BEAS2B_Human1.12732817
75STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.11837495
76SRY_22984422_ChIP-ChIP_TESTIS_Rat1.11615343
77GATA1_19941826_ChIP-Seq_K562_Human1.08059883
78GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08025412
79TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.07823157
80MAF_26560356_Chip-Seq_TH2_Human1.06092803
81KDM2B_26808549_Chip-Seq_JURKAT_Human1.05845044
82VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.05784968
83* MYC_22102868_ChIP-Seq_BL_Human1.03902296
84TET1_21451524_ChIP-Seq_MESCs_Mouse1.02556911
85GATA1_22383799_ChIP-Seq_G1ME_Mouse1.00989974
86ELK3_25401928_ChIP-Seq_HUVEC_Human1.00417094
87TFEB_21752829_ChIP-Seq_HELA_Human0.97272743
88TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.96966711
89VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.96652218
90NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.95449880
91TCF7_22412390_ChIP-Seq_EML_Mouse0.94922697
92HOXB4_20404135_ChIP-ChIP_EML_Mouse0.93310854
93SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.92625682
94CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.92298691
95ELF1_17652178_ChIP-ChIP_JURKAT_Human0.92093555
96GATA2_21666600_ChIP-Seq_HMVEC_Human0.91550297
97PPARA_22158963_ChIP-Seq_LIVER_Mouse0.91393572
98PU.1_20513432_ChIP-Seq_Bcells_Mouse0.91231709
99TP63_17297297_ChIP-ChIP_HaCaT_Human0.89732783
100ERG_20887958_ChIP-Seq_HPC-7_Mouse0.86828270
101RARG_19884340_ChIP-ChIP_MEFs_Mouse0.85830703
102TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85210762
103GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.84069354
104* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.82121386
105SPI1_20517297_ChIP-Seq_HL60_Human0.81606474
106SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.77995214
107EGR1_19032775_ChIP-ChIP_M12_Human0.76296635
108GATA1_19941827_ChIP-Seq_MEL_Mouse0.75567120
109TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.72895180
110ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.71354339
111IKZF1_21737484_ChIP-ChIP_HCT116_Human0.66363442
112CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.66202100
113BCL6_27268052_Chip-Seq_Bcells_Human0.64727247
114P300_27268052_Chip-Seq_Bcells_Human0.63755566
115NOTCH1_21737748_ChIP-Seq_TLL_Human0.63257120
116CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.63085936
117CTCF_26484167_Chip-Seq_Bcells_Mouse0.61965022
118P63_26484246_Chip-Seq_KERATINOCYTES_Human0.61139909
119CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.59674429
120KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.59477777
121SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.59042064
122SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.59042064

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.91968394
2MP0003436_decreased_susceptibility_to4.05766258
3MP0009785_altered_susceptibility_to3.89128675
4MP0002148_abnormal_hypersensitivity_rea3.62661934
5MP0006082_CNS_inflammation3.34987797
6MP0005000_abnormal_immune_tolerance3.27612234
7* MP0002419_abnormal_innate_immunity3.21070801
8* MP0005025_abnormal_response_to3.08562603
9MP0003303_peritoneal_inflammation3.03065727
10MP0000685_abnormal_immune_system2.99948086
11MP0005671_abnormal_response_to2.95783906
12MP0003724_increased_susceptibility_to2.89892075
13MP0001790_abnormal_immune_system2.86605737
14MP0005387_immune_system_phenotype2.86605737
15MP0002452_abnormal_antigen_presenting2.78701601
16MP0005058_abnormal_lysosome_morphology2.71511922
17MP0001800_abnormal_humoral_immune2.62807344
18MP0002723_abnormal_immune_serum2.60017799
19MP0004510_myositis2.58393265
20* MP0001819_abnormal_immune_cell2.41360819
21* MP0002420_abnormal_adaptive_immunity2.39588300
22MP0001853_heart_inflammation2.18348701
23MP0005464_abnormal_platelet_physiology2.17663815
24MP0001533_abnormal_skeleton_physiology2.08852585
25* MP0002405_respiratory_system_inflammati2.02289787
26* MP0001845_abnormal_inflammatory_respons1.96706100
27MP0009333_abnormal_splenocyte_physiolog1.84923947
28MP0004947_skin_inflammation1.82865467
29MP0002006_tumorigenesis1.81934684
30MP0010155_abnormal_intestine_physiology1.81790409
31MP0009764_decreased_sensitivity_to1.81123622
32MP0000716_abnormal_immune_system1.78699147
33MP0003172_abnormal_lysosome_physiology1.77432784
34MP0003448_altered_tumor_morphology1.72961273
35MP0005310_abnormal_salivary_gland1.72236504
36MP0002398_abnormal_bone_marrow1.70508915
37MP0008469_abnormal_protein_level1.68030669
38MP0000343_altered_response_to1.67583494
39MP0000858_altered_metastatic_potential1.59489607
40MP0003806_abnormal_nucleotide_metabolis1.59431193
41MP0002166_altered_tumor_susceptibility1.52472508
42MP0002998_abnormal_bone_remodeling1.49218480
43MP0003075_altered_response_to1.48339851
44MP0002429_abnormal_blood_cell1.46494898
45MP0003191_abnormal_cellular_cholesterol1.44948505
46MP0000689_abnormal_spleen_morphology1.44667325
47MP0002722_abnormal_immune_system1.36916530
48MP0003186_abnormal_redox_activity1.32286105
49MP0003763_abnormal_thymus_physiology1.31466096
50MP0005166_decreased_susceptibility_to1.24629360
51MP0009278_abnormal_bone_marrow1.22251082
52MP0002933_joint_inflammation1.21557966
53MP0005397_hematopoietic_system_phenotyp1.20346873
54MP0001545_abnormal_hematopoietic_system1.20346873
55MP0003300_gastrointestinal_ulcer1.18128475
56MP0004782_abnormal_surfactant_physiolog1.16273836
57MP0001873_stomach_inflammation1.08362126
58MP0005167_abnormal_blood-brain_barrier1.05965719
59MP0002138_abnormal_hepatobiliary_system1.05737995
60MP0002139_abnormal_hepatobiliary_system1.04617696
61MP0001851_eye_inflammation1.03425946
62MP0009840_abnormal_foam_cell1.02434604
63MP0003828_pulmonary_edema1.01005385
64MP0005390_skeleton_phenotype0.99993841
65MP0005174_abnormal_tail_pigmentation0.93514318
66MP0002254_reproductive_system_inflammat0.92969397
67MP0000490_abnormal_crypts_of0.92388458
68MP0009763_increased_sensitivity_to0.90006678
69MP0002396_abnormal_hematopoietic_system0.89698931
70MP0010307_abnormal_tumor_latency0.88245129
71MP0002277_abnormal_respiratory_mucosa0.87856979
72MP0005164_abnormal_response_to0.87823557
73MP0002136_abnormal_kidney_physiology0.86883730
74MP0000604_amyloidosis0.85436320
75MP0008004_abnormal_stomach_pH0.84781522
76MP0003183_abnormal_peptide_metabolism0.80869603
77MP0000465_gastrointestinal_hemorrhage0.79687684
78MP0003866_abnormal_defecation0.79169927
79MP0003795_abnormal_bone_structure0.78051162
80MP0000249_abnormal_blood_vessel0.76511522
81MP0000703_abnormal_thymus_morphology0.75902371
82MP0004808_abnormal_hematopoietic_stem0.75723941
83MP0003566_abnormal_cell_adhesion0.74118074
84MP0005076_abnormal_cell_differentiation0.73604198
85MP0003453_abnormal_keratinocyte_physiol0.68890301
86MP0008260_abnormal_autophagy0.68727843
87MP0000371_diluted_coat_color0.67959809
88MP0001663_abnormal_digestive_system0.67683882
89MP0003690_abnormal_glial_cell0.66220543
90MP0010352_gastrointestinal_tract_polyps0.65409853
91MP0005319_abnormal_enzyme/_coenzyme0.65159117
92MP0001958_emphysema0.63564305
93MP0005381_digestive/alimentary_phenotyp0.63223671
94MP0004381_abnormal_hair_follicle0.62827110
95MP0004858_abnormal_nervous_system0.62344019
96MP0008874_decreased_physiological_sensi0.62330277
97MP0003329_amyloid_beta_deposits0.61108336
98MP0005451_abnormal_body_composition0.60757040
99MP0004185_abnormal_adipocyte_glucose0.59979126
100MP0003195_calcinosis0.58499211
101MP0004883_abnormal_blood_vessel0.58290626
102MP0009765_abnormal_xenobiotic_induced0.58195599
103MP0002019_abnormal_tumor_incidence0.57994631
104MP0005165_increased_susceptibility_to0.56451459
105MP0002132_abnormal_respiratory_system0.56283759
106MP0000609_abnormal_liver_physiology0.55673374
107MP0003091_abnormal_cell_migration0.54440197
108MP0009643_abnormal_urine_homeostasis0.54000683
109MP0005023_abnormal_wound_healing0.53978227
110MP0005584_abnormal_enzyme/coenzyme_acti0.53369766
111MP0001849_ear_inflammation0.53305118
112MP0003656_abnormal_erythrocyte_physiolo0.52785127
113MP0000015_abnormal_ear_pigmentation0.52549091
114MP0005075_abnormal_melanosome_morpholog0.52150457
115MP0008873_increased_physiological_sensi0.48431473
116MP0000569_abnormal_digit_pigmentation0.47368447
117MP0005257_abnormal_intraocular_pressure0.46145940

Predicted human phenotypes

RankGene SetZ-score
1* Recurrent abscess formation (HP:0002722)7.12748421
2* Eczematoid dermatitis (HP:0000976)6.28818723
3* Recurrent bacterial skin infections (HP:0005406)6.00607456
4* Recurrent gram-negative bacterial infections (HP:0005420)5.25055380
5Elevated erythrocyte sedimentation rate (HP:0003565)4.83158396
6Vacuolated lymphocytes (HP:0001922)4.76740516
7* Abnormality of macrophages (HP:0004311)4.70863380
8Myositis (HP:0100614)4.47805467
9Autoimmune thrombocytopenia (HP:0001973)4.46202047
10Stomatitis (HP:0010280)4.34561101
11* Mediastinal lymphadenopathy (HP:0100721)4.34211468
12* Recurrent skin infections (HP:0001581)4.04924069
13Systemic lupus erythematosus (HP:0002725)3.98288735
14Increased cerebral lipofuscin (HP:0011813)3.96565770
15Orchitis (HP:0100796)3.96130273
16* Recurrent fungal infections (HP:0002841)3.81715988
17Increased neuronal autofluorescent lipopigment (HP:0002074)3.78679750
18Optic neuritis (HP:0100653)3.70456840
19Retrobulbar optic neuritis (HP:0100654)3.70456840
20* Gingivitis (HP:0000230)3.69621514
21* Chronic obstructive pulmonary disease (HP:0006510)3.60916756
22* Obstructive lung disease (HP:0006536)3.60916756
23Chronic mucocutaneous candidiasis (HP:0002728)3.54925907
24Recurrent cutaneous fungal infections (HP:0011370)3.54925907
25Vasculitis (HP:0002633)3.47983069
26Recurrent viral infections (HP:0004429)3.44056739
27Interstitial pulmonary disease (HP:0006530)3.43587986
28Increased IgM level (HP:0003496)3.43354715
29Pustule (HP:0200039)3.37962690
30Axonal loss (HP:0003447)3.32856024
31Increased IgE level (HP:0003212)3.28196261
32Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.25299995
33Basal ganglia calcification (HP:0002135)3.21425380
34Disinhibition (HP:0000734)3.09403411
35Dysostosis multiplex (HP:0000943)3.04937024
36Abnormality of glycolipid metabolism (HP:0010969)3.02175049
37Abnormality of liposaccharide metabolism (HP:0010968)3.02175049
38Abnormality of glycosphingolipid metabolism (HP:0004343)3.02175049
39Petechiae (HP:0000967)2.99460883
40Periodontitis (HP:0000704)2.94598129
41* Cellulitis (HP:0100658)2.88740628
42* Meningitis (HP:0001287)2.87603196
43Encephalitis (HP:0002383)2.87495595
44Chronic otitis media (HP:0000389)2.83074502
45Increased serum ferritin (HP:0003281)2.82712707
46Pulmonary infiltrates (HP:0002113)2.79080627
47Amyloidosis (HP:0011034)2.71398153
48* Urticaria (HP:0001025)2.67988278
49Hypergammaglobulinemia (HP:0010702)2.61113942
50IgM deficiency (HP:0002850)2.57573227
51Leukocytosis (HP:0001974)2.57440476
52Agnosia (HP:0010524)2.55230399
53Poor head control (HP:0002421)2.53687279
54Panhypogammaglobulinemia (HP:0003139)2.50317647
55Abnormality of T cell number (HP:0011839)2.50086680
56Hemoptysis (HP:0002105)2.49929146
57Prolonged bleeding time (HP:0003010)2.49767030
58Glomerulonephritis (HP:0000099)2.47810996
59Chest pain (HP:0100749)2.45637159
60Urinary glycosaminoglycan excretion (HP:0003541)2.43959133
61Mucopolysacchariduria (HP:0008155)2.43959133
62Epistaxis (HP:0000421)2.40374031
63Recurrent bronchitis (HP:0002837)2.39856412
64Hepatosplenomegaly (HP:0001433)2.38961884
65Arterial thrombosis (HP:0004420)2.36975466
66Abnormality of iron homeostasis (HP:0011031)2.35976561
67* Recurrent pneumonia (HP:0006532)2.35296414
68Granulocytopenia (HP:0001913)2.34060641
69Nasal polyposis (HP:0100582)2.33085634
70Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.32944251
71Prostate neoplasm (HP:0100787)2.30755804
72Spontaneous hematomas (HP:0007420)2.29367243
73Keratoconjunctivitis sicca (HP:0001097)2.28464810
74Abnormality of T cells (HP:0002843)2.27964086
75* Osteomyelitis (HP:0002754)2.27689781
76Gastrointestinal stroma tumor (HP:0100723)2.27403935
77Abnormality of cells of the lymphoid lineage (HP:0012140)2.27125548
78Keratoconjunctivitis (HP:0001096)2.26563615
79Abnormality of polysaccharide metabolism (HP:0011012)2.22986019
80Abnormality of glycosaminoglycan metabolism (HP:0004371)2.22986019
81Abnormality of mucopolysaccharide metabolism (HP:0011020)2.22986019
82Lymphopenia (HP:0001888)2.22227383
83Abnormality of T cell physiology (HP:0011840)2.22175913
84T lymphocytopenia (HP:0005403)2.20596313
85Tetraparesis (HP:0002273)2.18625890
86Purpura (HP:0000979)2.18325716
87Malnutrition (HP:0004395)2.18170069
88Episodic fever (HP:0001954)2.16925739
89Abnormality of the nasal mucosa (HP:0000433)2.16721396
90* Recurrent lower respiratory tract infections (HP:0002783)2.16680193
91Restrictive lung disease (HP:0002091)2.16216623
92Gingival bleeding (HP:0000225)2.15626244
93Hypochromic anemia (HP:0001931)2.13939491
94Hypertensive crisis (HP:0100735)2.13215391
95Loss of speech (HP:0002371)2.12543612
96Abnormal delayed hypersensitivity skin test (HP:0002963)2.12407692
97Progressive neurologic deterioration (HP:0002344)2.12087715
98Thick nail (HP:0001805)2.12054772
99Inflammation of the large intestine (HP:0002037)2.11759717
100Pulmonary embolism (HP:0002204)2.11350514
101Autoimmune hemolytic anemia (HP:0001890)2.11182233
102Thrombocytosis (HP:0001894)2.10416259
103Agammaglobulinemia (HP:0004432)2.10326170
104Cheilitis (HP:0100825)2.09250618
105* Sepsis (HP:0100806)2.07194491
106Colitis (HP:0002583)2.06410314
107Joint hemorrhage (HP:0005261)2.06383239
108Nausea (HP:0002018)2.03795090
109Abnormality of the pleura (HP:0002103)2.03788505
110Eosinophilia (HP:0001880)2.03695307
111Gastrointestinal infarctions (HP:0005244)2.03645689
112Upper motor neuron abnormality (HP:0002127)2.03437620
113Recurrent sinusitis (HP:0011108)2.03039637
114* Skin ulcer (HP:0200042)2.02725270
115Polygenic inheritance (HP:0010982)2.00835743
116Arthralgia (HP:0002829)1.98017988
117Bone pain (HP:0002653)1.97416335
118Gastrointestinal inflammation (HP:0004386)1.97413457
119Emphysema (HP:0002097)1.97068684
120Pathologic fracture (HP:0002756)1.96624292
121Anorexia (HP:0002039)1.96387716
122Myocardial infarction (HP:0001658)1.96137998
123Combined immunodeficiency (HP:0005387)1.96026429

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK4.30614053
2MAP3K144.11916169
3RIPK43.81678888
4TBK13.43977528
5MAP4K13.40682166
6IRAK43.25841818
7PBK3.00161003
8TYK22.77839248
9IKBKE2.63804504
10TXK2.58550424
11PRPF4B2.53617717
12IRAK32.50378659
13ERN12.36983998
14IKBKB2.34946884
15NME22.25904132
16JAK32.24848708
17KIT2.21190521
18PIM22.04947233
19ZAP701.88031488
20TAOK11.80327736
21TAOK21.76239208
22TNK21.72053710
23JAK11.65924387
24SYK1.65264426
25BTK1.58808898
26CSK1.53835921
27TEC1.42932287
28LYN1.33242596
29HCK1.33188471
30CHUK1.32796374
31SMG11.32330470
32NEK91.32111770
33CSF1R1.30074419
34STK101.29899718
35PIM11.27073063
36MST41.26800151
37MAP3K131.26591196
38ABL21.25836250
39RPS6KA41.23808304
40LCK1.21044304
41MAP3K11.20112436
42TGFBR21.15992732
43SIK11.14307573
44KDR1.13213390
45CLK11.09867411
46LRRK21.07441396
47STK40.97254045
48BMX0.96781706
49MAP3K120.94428754
50MST1R0.92469068
51JAK20.91107083
52MAP2K30.91009580
53MARK30.90835932
54EPHB10.89577255
55MATK0.87746854
56BMPR20.86737144
57TRPM70.86242376
58CDC42BPA0.85090210
59TESK10.84352171
60ITK0.84111037
61FES0.83116990
62MAP3K110.82640875
63PDPK10.79696719
64TAOK30.79573977
65FGR0.79540040
66GRK60.77823947
67PRKD20.77238586
68PDK10.76107612
69FGFR40.72411585
70MARK20.71272598
71SIK20.68587809
72EIF2AK20.67894180
73* PRKCD0.65197927
74MAPK120.64644710
75FGFR30.62705776
76ABL10.61807238
77TESK20.60191104
78ERBB30.58049030
79YES10.56089641
80SIK30.54745265
81ARAF0.54691611
82GRK70.54503288
83HIPK20.53777365
84EGFR0.52782236
85TRIB30.52516974
86MAP2K20.52093765
87KSR20.52027823
88CDK40.51916395
89ICK0.50309903
90MAPK110.49801315
91PRKCQ0.49062824
92MAP2K60.47877637
93MAP3K80.47090289
94RPS6KA60.45257291
95CAMKK20.42783580
96MAP3K100.42560714
97PAK40.42161998
98BCKDK0.41618219
99MAPKAPK20.39581300
100MAPK40.38475567
101CAMKK10.38195364
102NLK0.37716472
103MAP3K50.37189346
104PTK60.36854757
105MAPK70.36846925
106DYRK1B0.36402522
107MAP3K30.36289430
108RPS6KA20.36188532
109IRAK10.35918004
110DAPK30.35344110
111EIF2AK30.35185844
112PKN20.35037991
113PRKG20.33865572
114RPS6KC10.31914113
115RPS6KL10.31914113
116ADRBK20.31450893
117TTN0.30266770
118RIPK10.29445421
119EPHA30.29016126
120EIF2AK10.28814309
121MOS0.28436306
122FYN0.28420789
123SCYL20.28084180
124ACVR1B0.27774337
125FLT30.26280242
126BMPR1B0.24361506
127MYLK0.23991654
128IGF1R0.22272410
129IRAK20.22210348

Predicted pathways (KEGG)

RankGene SetZ-score
1* Leishmaniasis_Homo sapiens_hsa051403.25345807
2Graft-versus-host disease_Homo sapiens_hsa053323.23044994
3Staphylococcus aureus infection_Homo sapiens_hsa051502.80811760
4Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.65927038
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.64715496
6Allograft rejection_Homo sapiens_hsa053302.63502091
7Legionellosis_Homo sapiens_hsa051342.60563070
8Toll-like receptor signaling pathway_Homo sapiens_hsa046202.58703291
9Asthma_Homo sapiens_hsa053102.40248009
10* Osteoclast differentiation_Homo sapiens_hsa043802.27976909
11Tuberculosis_Homo sapiens_hsa051522.27661131
12Pertussis_Homo sapiens_hsa051332.24153537
13Intestinal immune network for IgA production_Homo sapiens_hsa046722.20886966
14NOD-like receptor signaling pathway_Homo sapiens_hsa046212.19617254
15Rheumatoid arthritis_Homo sapiens_hsa053232.19353126
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.16988713
17Malaria_Homo sapiens_hsa051442.16621480
18Lysosome_Homo sapiens_hsa041422.11443111
19Measles_Homo sapiens_hsa051622.07269353
20RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.06511900
21Other glycan degradation_Homo sapiens_hsa005111.93998069
22Antigen processing and presentation_Homo sapiens_hsa046121.87167144
23Primary immunodeficiency_Homo sapiens_hsa053401.85350445
24Salmonella infection_Homo sapiens_hsa051321.80002534
25Hematopoietic cell lineage_Homo sapiens_hsa046401.78211253
26Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.70607402
27TNF signaling pathway_Homo sapiens_hsa046681.65636017
28* Phagosome_Homo sapiens_hsa041451.64867108
29Type I diabetes mellitus_Homo sapiens_hsa049401.64410512
30B cell receptor signaling pathway_Homo sapiens_hsa046621.63894442
31Influenza A_Homo sapiens_hsa051641.62482505
32Glycosaminoglycan degradation_Homo sapiens_hsa005311.59197713
33Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.51778869
34Herpes simplex infection_Homo sapiens_hsa051681.48041084
35Toxoplasmosis_Homo sapiens_hsa051451.47682143
36Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.45200035
37Apoptosis_Homo sapiens_hsa042101.42039629
38Shigellosis_Homo sapiens_hsa051311.40928803
39Chemokine signaling pathway_Homo sapiens_hsa040621.34942435
40Autoimmune thyroid disease_Homo sapiens_hsa053201.33872274
41Jak-STAT signaling pathway_Homo sapiens_hsa046301.27955448
42African trypanosomiasis_Homo sapiens_hsa051431.25169994
43Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.23423192
44Viral myocarditis_Homo sapiens_hsa054161.20648807
45Hepatitis B_Homo sapiens_hsa051611.01056427
46* Leukocyte transendothelial migration_Homo sapiens_hsa046700.98477804
47Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.93498027
48T cell receptor signaling pathway_Homo sapiens_hsa046600.92783621
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.91770074
50Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.90459453
51AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.89365999
52Proteasome_Homo sapiens_hsa030500.84058579
53Hepatitis C_Homo sapiens_hsa051600.82428386
54Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.82426272
55Collecting duct acid secretion_Homo sapiens_hsa049660.79382276
56Non-small cell lung cancer_Homo sapiens_hsa052230.76086728
57Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.75578202
58Amoebiasis_Homo sapiens_hsa051460.74621585
59Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.73116074
60Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71644549
61Acute myeloid leukemia_Homo sapiens_hsa052210.66101492
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65708031
63Bladder cancer_Homo sapiens_hsa052190.64813182
64Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.62531212
65Galactose metabolism_Homo sapiens_hsa000520.61535282
66Platelet activation_Homo sapiens_hsa046110.59824316
67Epstein-Barr virus infection_Homo sapiens_hsa051690.59062737
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56732000
69Complement and coagulation cascades_Homo sapiens_hsa046100.56323966
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53420467
71Fructose and mannose metabolism_Homo sapiens_hsa000510.53138636
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50879378
73Pancreatic cancer_Homo sapiens_hsa052120.49507484
74Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48888877
75Chronic myeloid leukemia_Homo sapiens_hsa052200.45773212
76Notch signaling pathway_Homo sapiens_hsa043300.45081453
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.40611772
78Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40041550
79Viral carcinogenesis_Homo sapiens_hsa052030.39880681
80Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38212422
81HIF-1 signaling pathway_Homo sapiens_hsa040660.37098006
82Pentose phosphate pathway_Homo sapiens_hsa000300.36770473
83Prion diseases_Homo sapiens_hsa050200.36691715
84Mineral absorption_Homo sapiens_hsa049780.35346594
85Phospholipase D signaling pathway_Homo sapiens_hsa040720.34771501
86Renal cell carcinoma_Homo sapiens_hsa052110.34158197
87HTLV-I infection_Homo sapiens_hsa051660.33752645
88Carbohydrate digestion and absorption_Homo sapiens_hsa049730.33501119
89Glycerophospholipid metabolism_Homo sapiens_hsa005640.31538707
90Prolactin signaling pathway_Homo sapiens_hsa049170.31104571
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.30974041
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.30678723
93p53 signaling pathway_Homo sapiens_hsa041150.28917158
94Renin-angiotensin system_Homo sapiens_hsa046140.28381253
95Small cell lung cancer_Homo sapiens_hsa052220.28249674
96Regulation of actin cytoskeleton_Homo sapiens_hsa048100.28232064
97Caffeine metabolism_Homo sapiens_hsa002320.28193138
98Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.27621049
99Ribosome_Homo sapiens_hsa030100.26290914
100Sphingolipid metabolism_Homo sapiens_hsa006000.25906263
101Insulin resistance_Homo sapiens_hsa049310.25415903
102Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.24303377
103Vibrio cholerae infection_Homo sapiens_hsa051100.23406687
104mTOR signaling pathway_Homo sapiens_hsa041500.22982892
105Endocytosis_Homo sapiens_hsa041440.22821430
106VEGF signaling pathway_Homo sapiens_hsa043700.20952309
107GnRH signaling pathway_Homo sapiens_hsa049120.20677784
108Base excision repair_Homo sapiens_hsa034100.20211762
109Choline metabolism in cancer_Homo sapiens_hsa052310.17634305
110FoxO signaling pathway_Homo sapiens_hsa040680.17082992
111Homologous recombination_Homo sapiens_hsa034400.16769820
112Proteoglycans in cancer_Homo sapiens_hsa052050.15809050
113Arachidonic acid metabolism_Homo sapiens_hsa005900.14887659
114Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.13277184
115Systemic lupus erythematosus_Homo sapiens_hsa053220.12954770

Most similar genes based on co-expression Upload to Enrichr

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