CYBRD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the cytochrome b(561) family that encodes an iron-regulated protein. It highly expressed in the duodenal brush border membrane. It has ferric reductase activity and is believed to play a physiological role in dietary iron absorption. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maintenance of gastrointestinal epithelium (GO:0030277)7.47870595
2thyroid gland development (GO:0030878)5.80327817
3epithelial structure maintenance (GO:0010669)5.75299341
4virion attachment to host cell (GO:0019062)5.40436568
5adhesion of symbiont to host cell (GO:0044650)5.40436568
6response to parathyroid hormone (GO:0071107)5.23317282
7sulfate transmembrane transport (GO:1902358)4.77235034
8adhesion of symbiont to host (GO:0044406)4.59637996
9angiotensin maturation (GO:0002003)4.54481868
10sequestering of extracellular ligand from receptor (GO:0035581)4.47711795
11extracellular matrix assembly (GO:0085029)4.37513573
12protein heterotrimerization (GO:0070208)4.22933134
13sulfate transport (GO:0008272)4.16283604
14extracellular fibril organization (GO:0043206)4.15766043
15collagen fibril organization (GO:0030199)3.99693074
16kidney morphogenesis (GO:0060993)3.94010343
17bundle of His cell to Purkinje myocyte communication (GO:0086069)3.89154809
18positive regulation of glycogen biosynthetic process (GO:0045725)3.87400793
19lateral sprouting from an epithelium (GO:0060601)3.86924465
20peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.86372609
21positive regulation of vascular permeability (GO:0043117)3.75762101
22regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.74553697
23cell migration involved in heart development (GO:0060973)3.70765766
24type B pancreatic cell proliferation (GO:0044342)3.64015423
25response to lead ion (GO:0010288)3.63937885
26blood vessel maturation (GO:0001955)3.63366717
27hemidesmosome assembly (GO:0031581)3.61280172
28bicarbonate transport (GO:0015701)3.56905502
29digestive system process (GO:0022600)3.54489865
30hair follicle morphogenesis (GO:0031069)3.52123722
31lung secretory cell differentiation (GO:0061140)3.45216933
32fibril organization (GO:0097435)3.42388721
33positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.37392748
34O-glycan processing (GO:0016266)3.37018145
35lipoprotein transport (GO:0042953)3.32189643
36regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.29285341
37endodermal cell differentiation (GO:0035987)3.28236638
38positive regulation of glycogen metabolic process (GO:0070875)3.26932678
39barbed-end actin filament capping (GO:0051016)3.24997530
40negative regulation of smooth muscle cell migration (GO:0014912)3.19231732
41multicellular organismal macromolecule metabolic process (GO:0044259)3.17448267
42multicellular organismal metabolic process (GO:0044236)3.16160744
43vascular endothelial growth factor signaling pathway (GO:0038084)3.15777984
44multicellular organismal catabolic process (GO:0044243)3.12634090
45negative regulation of fatty acid transport (GO:2000192)3.11240269
46chondrocyte proliferation (GO:0035988)3.08869447
47skin morphogenesis (GO:0043589)3.08844569
48regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.08436253
49cellular response to vitamin (GO:0071295)3.08217396
50positive regulation of extracellular matrix organization (GO:1903055)3.06531529
51mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.05915148
52hydrogen peroxide catabolic process (GO:0042744)3.05771813
53vitamin A metabolic process (GO:0006776)3.05669109
54regulation of somitogenesis (GO:0014807)3.04929741
55metanephric mesenchyme development (GO:0072075)3.02072334
56digestion (GO:0007586)3.00637708
57collagen metabolic process (GO:0032963)2.97931365
58positive regulation of endothelial cell apoptotic process (GO:2000353)2.96662236
59regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.96101060
60bone resorption (GO:0045453)2.94953581
61negative regulation of hormone metabolic process (GO:0032351)2.93570617
62negative regulation of hormone biosynthetic process (GO:0032353)2.93570617
63kidney mesenchyme development (GO:0072074)2.93204598
64regulation of extracellular matrix disassembly (GO:0010715)2.92785262
65sodium ion export (GO:0071436)2.91982611
66apoptotic cell clearance (GO:0043277)2.91918538
67endocardial cushion morphogenesis (GO:0003203)2.90868010
68phenol-containing compound metabolic process (GO:0018958)2.88008770
69smooth muscle tissue development (GO:0048745)2.86892633
70collagen catabolic process (GO:0030574)2.83349595
71mesenchyme morphogenesis (GO:0072132)2.82611286
72branching involved in salivary gland morphogenesis (GO:0060445)2.78070356
73epithelial tube branching involved in lung morphogenesis (GO:0060441)2.75843383
74response to vitamin D (GO:0033280)2.72381179
75peptide catabolic process (GO:0043171)2.70336145
76cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.68355407
77extracellular regulation of signal transduction (GO:1900115)2.67804579
78extracellular negative regulation of signal transduction (GO:1900116)2.67804579
79G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.65980472
80atrioventricular valve morphogenesis (GO:0003181)2.63353201
81hormone catabolic process (GO:0042447)2.61659785
82extracellular matrix disassembly (GO:0022617)2.61413386
83planar cell polarity pathway involved in neural tube closure (GO:0090179)2.61252018
84cGMP-mediated signaling (GO:0019934)2.61131674
85chondrocyte development (GO:0002063)2.60041016
86surfactant homeostasis (GO:0043129)2.59819476
87dermatan sulfate metabolic process (GO:0030205)2.57344236
88cellular response to gonadotropin stimulus (GO:0071371)2.57250361
89bone trabecula formation (GO:0060346)2.55800584
90cell adhesion mediated by integrin (GO:0033627)2.55578522
91limb bud formation (GO:0060174)2.55347981
92hormone biosynthetic process (GO:0042446)2.55122646
93endocardial cushion development (GO:0003197)2.54020090
94heart valve morphogenesis (GO:0003179)2.52780021
95negative regulation of leukocyte chemotaxis (GO:0002689)2.52666400
96positive regulation of glucose import (GO:0046326)2.48586378
97regulation of integrin-mediated signaling pathway (GO:2001044)2.48148883
98regulation of steroid hormone biosynthetic process (GO:0090030)2.47606257
99cellular response to nutrient (GO:0031670)2.47590530
100mannose metabolic process (GO:0006013)2.46584477
101regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.46352653
102dermatan sulfate biosynthetic process (GO:0030208)2.46205210
103glandular epithelial cell differentiation (GO:0002067)2.46174414
104extracellular matrix organization (GO:0030198)2.45247788
105regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.44809688
106extracellular structure organization (GO:0043062)2.44224441
107stress fiber assembly (GO:0043149)2.43958658
108renal filtration (GO:0097205)2.43401104
109regulation of smooth muscle cell migration (GO:0014910)2.42248492
110NADH metabolic process (GO:0006734)2.41203662
111renal system process involved in regulation of blood volume (GO:0001977)2.39605115
112negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.38559949
113renal system development (GO:0072001)2.37960285
114retina vasculature morphogenesis in camera-type eye (GO:0061299)2.37893680
115regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.37783711
116positive regulation of bone mineralization (GO:0030501)2.37686558
117regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.37604112
118membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.37026771
119positive regulation of receptor recycling (GO:0001921)2.36981023
120regulation of glucocorticoid metabolic process (GO:0031943)2.36628589
121regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.36390526
122endocrine process (GO:0050886)2.36390526
123regulation of systemic arterial blood pressure by hormone (GO:0001990)2.36390526
124hair cycle process (GO:0022405)2.35804843
125molting cycle process (GO:0022404)2.35804843
126lung vasculature development (GO:0060426)2.35131189
127lung-associated mesenchyme development (GO:0060484)2.34450780
128establishment of planar polarity (GO:0001736)2.34377079
129establishment of tissue polarity (GO:0007164)2.34377079
130glomerular basement membrane development (GO:0032836)2.34256361
131endothelial cell morphogenesis (GO:0001886)2.34084136
132phosphorelay signal transduction system (GO:0000160)2.33871321
133negative regulation of chondrocyte differentiation (GO:0032331)2.32811153
134regulation of extracellular matrix organization (GO:1903053)2.32413699
135negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.31428087
136protein O-linked glycosylation (GO:0006493)2.30949970
137venous blood vessel morphogenesis (GO:0048845)2.29305381
138desmosome organization (GO:0002934)2.28519040
139intestinal absorption (GO:0050892)2.28290811
140cellular potassium ion homeostasis (GO:0030007)2.27180101
141positive regulation of osteoblast proliferation (GO:0033690)2.27113766
142outer ear morphogenesis (GO:0042473)2.26701758
143lung cell differentiation (GO:0060479)2.26589255
144negative regulation of complement activation (GO:0045916)2.26423051
145regulation of cell fate specification (GO:0042659)2.25224023
146glomerular filtration (GO:0003094)2.25124887
147epithelial cell-cell adhesion (GO:0090136)2.25064590
148astrocyte differentiation (GO:0048708)2.24942052
149lung epithelium development (GO:0060428)2.24667588
150regulation of non-canonical Wnt signaling pathway (GO:2000050)2.24404055
151cellular response to vitamin D (GO:0071305)2.24189695
152eye photoreceptor cell differentiation (GO:0001754)2.24054051
153photoreceptor cell differentiation (GO:0046530)2.24054051
154cell-substrate junction assembly (GO:0007044)2.23974446
155neuron projection extension involved in neuron projection guidance (GO:1902284)2.23974281
156axon extension involved in axon guidance (GO:0048846)2.23974281
157positive regulation of biomineral tissue development (GO:0070169)2.23907871
158substrate-dependent cell migration (GO:0006929)2.23437562
159negative regulation of protein localization to plasma membrane (GO:1903077)2.23415762
160positive regulation of mesenchymal cell proliferation (GO:0002053)2.23114883
161negative regulation of BMP signaling pathway (GO:0030514)2.22745264
162glutathione derivative biosynthetic process (GO:1901687)2.22653651
163glutathione derivative metabolic process (GO:1901685)2.22653651
164keratan sulfate catabolic process (GO:0042340)2.21743569
165cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.21725998
166protein localization to cell surface (GO:0034394)2.21263221
1673-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.21259823
168purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.21259823
169negative regulation of sodium ion transport (GO:0010766)2.21255505
170cellular response to cholesterol (GO:0071397)2.20921881
171mesenchymal-epithelial cell signaling (GO:0060638)2.20905188
172developmental induction (GO:0031128)2.20213903
173digestive tract morphogenesis (GO:0048546)2.19750482
174phospholipid scrambling (GO:0017121)2.19342340
175glomerulus development (GO:0032835)2.18997327
176regulation of mesenchymal cell proliferation (GO:0010464)2.18944311
177* response to iron ion (GO:0010039)2.18241584
178cell proliferation involved in metanephros development (GO:0072203)2.17795758
179positive regulation of fibroblast migration (GO:0010763)2.17655245
180negative regulation of nitric oxide biosynthetic process (GO:0045019)2.14371292
181regulation of systemic arterial blood pressure (GO:0003073)2.14365884
182cellular response to reactive nitrogen species (GO:1902170)2.13678174
183basement membrane organization (GO:0071711)2.13650924
184positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.13581001
185endocrine hormone secretion (GO:0060986)2.12886288
186positive regulation of pseudopodium assembly (GO:0031274)2.09543662
187thyroid hormone generation (GO:0006590)17.7454588
188thyroid hormone metabolic process (GO:0042403)15.2232728

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.08689719
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.55768924
3ESR2_21235772_ChIP-Seq_MCF-7_Human2.61041737
4ESR1_21235772_ChIP-Seq_MCF-7_Human2.59610752
5SOX2_27498859_Chip-Seq_STOMACH_Mouse2.17031082
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.06605460
7ESR1_20079471_ChIP-ChIP_T-47D_Human2.05584967
8CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.05023536
9CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.01622791
10ZNF217_24962896_ChIP-Seq_MCF-7_Human2.00640917
11RARG_19884340_ChIP-ChIP_MEFs_Mouse1.94206635
12EP300_21415370_ChIP-Seq_HL-1_Mouse1.86615954
13ESR1_15608294_ChIP-ChIP_MCF-7_Human1.82784142
14CDX2_19796622_ChIP-Seq_MESCs_Mouse1.80942354
15RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.79853505
16SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.79360817
17SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.77612720
18ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.76221544
19EED_16625203_ChIP-ChIP_MESCs_Mouse1.75934127
20* SOX2_20726797_ChIP-Seq_SW620_Human1.75345636
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.74416413
22CDX2_20551321_ChIP-Seq_CACO-2_Human1.74367051
23AR_21572438_ChIP-Seq_LNCaP_Human1.73804691
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.68230224
25RNF2_18974828_ChIP-Seq_MESCs_Mouse1.67883984
26EZH2_18974828_ChIP-Seq_MESCs_Mouse1.67883984
27BRD4_25478319_ChIP-Seq_HGPS_Human1.67220961
28FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.66379849
29AHR_22903824_ChIP-Seq_MCF-7_Human1.65743278
30SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.62589589
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.62455972
32CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.62082354
33TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.61796307
34JARID2_20075857_ChIP-Seq_MESCs_Mouse1.58674873
35JARID2_20064375_ChIP-Seq_MESCs_Mouse1.58626050
36SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.54351710
37GATA1_22025678_ChIP-Seq_K562_Human1.53945513
38RNF2_27304074_Chip-Seq_ESCs_Mouse1.52616367
39SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.52238623
40FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.52009760
41Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.50599019
42NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.50414528
43PPAR_26484153_Chip-Seq_NCI-H1993_Human1.49896359
44KLF5_25053715_ChIP-Seq_YYC3_Human1.49569613
45TP53_18474530_ChIP-ChIP_U2OS_Human1.43973084
46NR3C1_21868756_ChIP-Seq_MCF10A_Human1.42880458
47IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.42658430
48PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.41074192
49GATA4_25053715_ChIP-Seq_YYC3_Human1.40749334
50DROSHA_22980978_ChIP-Seq_HELA_Human1.40393804
51ARNT_22903824_ChIP-Seq_MCF-7_Human1.40387098
52RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.39552210
53* CJUN_26792858_Chip-Seq_BT549_Human1.38156814
54ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.38111672
55LXR_22158963_ChIP-Seq_LIVER_Mouse1.37497450
56EZH2_27304074_Chip-Seq_ESCs_Mouse1.35894200
57SOX9_24532713_ChIP-Seq_HFSC_Mouse1.35513600
58TBX20_22328084_ChIP-Seq_HEART_Mouse1.35337335
59TBX20_22080862_ChIP-Seq_HEART_Mouse1.35337335
60EZH2_27294783_Chip-Seq_ESCs_Mouse1.33602422
61* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.33368550
62PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.33225226
63EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.33051280
64RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32306717
65PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.30868700
66STAT6_21828071_ChIP-Seq_BEAS2B_Human1.30851447
67ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.29478492
68BP1_19119308_ChIP-ChIP_Hs578T_Human1.29257107
69THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.28793542
70* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.25187004
71PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.24024169
72RXR_22158963_ChIP-Seq_LIVER_Mouse1.22367045
73RXR_22108803_ChIP-Seq_LS180_Human1.21502737
74NFIB_24661679_ChIP-Seq_LUNG_Mouse1.21275900
75TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20239120
76TP53_16413492_ChIP-PET_HCT116_Human1.20123170
77FOXM1_26456572_ChIP-Seq_MCF-7_Human1.20119309
78* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.19783630
79TCF4_18268006_ChIP-ChIP_LS174T_Human1.19673872
80HIF1A_21447827_ChIP-Seq_MCF-7_Human1.18911819
81GBX2_23144817_ChIP-Seq_PC3_Human1.18584639
82PIAS1_25552417_ChIP-Seq_VCAP_Human1.18186238
83WT1_19549856_ChIP-ChIP_CCG9911_Human1.17187990
84ELK3_25401928_ChIP-Seq_HUVEC_Human1.16957407
85WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.16733844
86ISL1_27105846_Chip-Seq_CPCs_Mouse1.16111588
87NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.15692302
88SMC1_22415368_ChIP-Seq_MEFs_Mouse1.15314814
89BCAT_22108803_ChIP-Seq_LS180_Human1.12545001
90RING1B_27294783_Chip-Seq_NPCs_Mouse1.12450965
91WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12409428
92NRF2_20460467_ChIP-Seq_MEFs_Mouse1.11411030
93NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.11411030
94SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.10426073
95SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.10426073
96GATA2_21666600_ChIP-Seq_HMVEC_Human1.08869020
97JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08703273
98SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08651076
99BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.07777927
100SMAD_19615063_ChIP-ChIP_OVARY_Human1.05713979
101TP53_20018659_ChIP-ChIP_R1E_Mouse1.05535159
102JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05510698
103TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.05166855
104CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.02165280
105ERG_21242973_ChIP-ChIP_JURKAT_Human1.01970104
106SMAD3_21741376_ChIP-Seq_HESCs_Human1.01936424
107MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.99428232
108RING1B_27294783_Chip-Seq_ESCs_Mouse0.99269489
109CLOCK_20551151_ChIP-Seq_293T_Human0.98036378
110AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.97430803
111SA1_22415368_ChIP-Seq_MEFs_Mouse0.96780092
112RUNX1_27514584_Chip-Seq_MCF-7_Human0.96296261
113GATA3_24758297_ChIP-Seq_MCF-7_Human0.95489068
114PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95017751
115CTNNB1_20460455_ChIP-Seq_HCT116_Human0.94892617
116CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.93866107
117NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.93798499
118FOXO3_23340844_ChIP-Seq_DLD1_Human0.93766653
119PPARA_22158963_ChIP-Seq_LIVER_Mouse0.92561459
120P63_26484246_Chip-Seq_KERATINOCYTES_Human0.92249760
121SMAD3_21741376_ChIP-Seq_EPCs_Human0.91270294
122NR3C1_23031785_ChIP-Seq_PC12_Mouse0.90737222
123PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.90448877
124KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.89019572
125ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.88336904
126YAP1_20516196_ChIP-Seq_MESCs_Mouse0.87803574
127SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.87645033
128PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.87583576
129P300_27058665_Chip-Seq_ZR-75-30cells_Human0.87352130
130STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.86970396
131SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.86865100
132VDR_24787735_ChIP-Seq_THP-1_Human0.86864767
133SALL4_18804426_ChIP-ChIP_XEN_Mouse0.86360552
134SMAD4_21741376_ChIP-Seq_HESCs_Human0.85677781
135* TP63_23658742_ChIP-Seq_EP156T_Human0.84761196
136GATA1_19941826_ChIP-Seq_K562_Human0.84610611
137SMC3_22415368_ChIP-Seq_MEFs_Mouse0.84174730
138TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83985830
139PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.82908667
140FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.82684933
141TP53_23651856_ChIP-Seq_MEFs_Mouse0.78880715
142KDM2B_26808549_Chip-Seq_SUP-B15_Human0.77540217

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000383_abnormal_hair_follicle4.36400774
2MP0000681_abnormal_thyroid_gland4.30448883
3MP0001873_stomach_inflammation4.19598740
4MP0010678_abnormal_skin_adnexa3.88215709
5MP0003279_aneurysm3.42201098
6MP0001664_abnormal_digestion3.21887764
7MP0000678_abnormal_parathyroid_gland3.02153261
8MP0000566_synostosis2.95003285
9MP0005360_urolithiasis2.51896098
10MP0010234_abnormal_vibrissa_follicle2.50491399
11MP0005257_abnormal_intraocular_pressure2.30491520
12MP0001663_abnormal_digestive_system2.30388189
13MP0001542_abnormal_bone_strength2.26475151
14MP0010368_abnormal_lymphatic_system2.15561089
15MP0005381_digestive/alimentary_phenotyp2.13233650
16MP0000470_abnormal_stomach_morphology2.10426358
17MP0000537_abnormal_urethra_morphology2.04179703
18MP0008004_abnormal_stomach_pH10.7113247
19MP0009250_abnormal_appendicular_skeleto1.91315259
20MP0004858_abnormal_nervous_system1.84724695
21MP0000751_myopathy1.81427206
22MP0009780_abnormal_chondrocyte_physiolo1.79940310
23MP0003878_abnormal_ear_physiology1.79891974
24MP0005377_hearing/vestibular/ear_phenot1.79891974
25MP0000462_abnormal_digestive_system1.79373559
26MP0002108_abnormal_muscle_morphology1.75499410
27MP0009384_cardiac_valve_regurgitation1.72836540
28MP0000767_abnormal_smooth_muscle1.64675137
29MP0005670_abnormal_white_adipose1.64203732
30MP0000762_abnormal_tongue_morphology1.63653273
31MP0009053_abnormal_anal_canal1.62719046
32MP0009840_abnormal_foam_cell1.62386279
33MP0002295_abnormal_pulmonary_circulatio1.62348133
34MP0003091_abnormal_cell_migration1.60979176
35MP0005023_abnormal_wound_healing1.60526764
36MP0004272_abnormal_basement_membrane1.53116035
37MP0002098_abnormal_vibrissa_morphology1.52087822
38MP0004043_abnormal_pH_regulation1.49859939
39MP0005595_abnormal_vascular_smooth1.42180104
40MP0002876_abnormal_thyroid_physiology1.41884700
41MP0010352_gastrointestinal_tract_polyps1.41008773
42MP0000013_abnormal_adipose_tissue1.40567870
43MP0003941_abnormal_skin_development1.38571940
44MP0002254_reproductive_system_inflammat1.37994512
45MP0005508_abnormal_skeleton_morphology1.37843232
46MP0003879_abnormal_hair_cell1.34632051
47MP0004264_abnormal_extraembryonic_tissu1.32592852
48MP0002249_abnormal_larynx_morphology1.31664773
49MP0005409_darkened_coat_color1.29759544
50MP0005165_increased_susceptibility_to1.29302103
51MP0003191_abnormal_cellular_cholesterol1.29249592
52MP0003183_abnormal_peptide_metabolism1.27171251
53MP0005164_abnormal_response_to1.26324470
54MP0000163_abnormal_cartilage_morphology1.24951079
55MP0003300_gastrointestinal_ulcer1.24067528
56MP0002998_abnormal_bone_remodeling1.22751798
57MP0000579_abnormal_nail_morphology1.22466523
58MP0002896_abnormal_bone_mineralization1.22387557
59MP0006138_congestive_heart_failure1.21747209
60MP0002282_abnormal_trachea_morphology1.21683169
61MP0001485_abnormal_pinna_reflex1.21549831
62MP0003724_increased_susceptibility_to1.19537282
63MP0009379_abnormal_foot_pigmentation1.18693686
64MP0005388_respiratory_system_phenotype1.16736757
65MP0002133_abnormal_respiratory_system1.16736757
66MP0003828_pulmonary_edema1.16518553
67MP0005248_abnormal_Harderian_gland1.15591615
68MP0000049_abnormal_middle_ear1.14845056
69MP0001346_abnormal_lacrimal_gland1.14230385
70MP0002933_joint_inflammation1.13307877
71MP0004885_abnormal_endolymph1.10043368
72MP0003942_abnormal_urinary_system1.07693120
73MP0002971_abnormal_brown_adipose1.06321563
74MP0001243_abnormal_dermal_layer1.05893044
75MP0001879_abnormal_lymphatic_vessel1.05494782
76MP0005167_abnormal_blood-brain_barrier1.04570000
77MP0001533_abnormal_skeleton_physiology1.03729406
78MP0002234_abnormal_pharynx_morphology1.03586913
79MP0002009_preneoplasia1.03438450
80MP0001849_ear_inflammation1.02685826
81MP0004134_abnormal_chest_morphology1.01968075
82MP0000026_abnormal_inner_ear1.01458522
83MP0002796_impaired_skin_barrier0.99006046
84MP0000534_abnormal_ureter_morphology0.98411602
85MP0003755_abnormal_palate_morphology0.97579788
86MP0006054_spinal_hemorrhage0.97120474
87MP0002089_abnormal_postnatal_growth/wei0.97018808
88MP0002116_abnormal_craniofacial_bone0.96788207
89MP0003566_abnormal_cell_adhesion0.96080848
90MP0000249_abnormal_blood_vessel0.95791252
91MP0000477_abnormal_intestine_morphology0.95752024
92MP0000432_abnormal_head_morphology0.95458583
93MP0004883_abnormal_blood_vessel0.93767489
94MP0008438_abnormal_cutaneous_collagen0.92715503
95MP0003115_abnormal_respiratory_system0.92548490
96MP0004084_abnormal_cardiac_muscle0.91587480
97MP0005085_abnormal_gallbladder_physiolo0.91269285
98MP0001666_abnormal_nutrient_absorption0.90171010
99MP0000647_abnormal_sebaceous_gland0.90090839
100MP0000428_abnormal_craniofacial_morphol0.89957202
101MP0005503_abnormal_tendon_morphology0.89929733
102MP0010030_abnormal_orbit_morphology0.86581870
103MP0002115_abnormal_skeleton_extremities0.85719308
104MP0005623_abnormal_meninges_morphology0.85018068
105MP0003705_abnormal_hypodermis_morpholog0.84646298
106MP0005058_abnormal_lysosome_morphology0.83883772
107MP0005666_abnormal_adipose_tissue0.83639795
108MP0000343_altered_response_to0.83124138
109MP0010771_integument_phenotype0.82995433
110MP0000613_abnormal_salivary_gland0.82377288
111MP0002113_abnormal_skeleton_development0.81982453
112MP0005275_abnormal_skin_tensile0.81364681
113MP0002233_abnormal_nose_morphology0.80552675
114MP0005375_adipose_tissue_phenotype0.79826812
115MP0003448_altered_tumor_morphology0.79786494
116MP0003935_abnormal_craniofacial_develop0.79528053
117MP0001963_abnormal_hearing_physiology0.79411614
118MP0004782_abnormal_surfactant_physiolog0.78987887
119MP0003937_abnormal_limbs/digits/tail_de0.78790422
120MP0002877_abnormal_melanocyte_morpholog0.77674377
121MP0003868_abnormal_feces_composition0.76132307
122MP0010386_abnormal_urinary_bladder0.75161834
123MP0000467_abnormal_esophagus_morphology0.74594705
124MP0005365_abnormal_bile_salt0.74544547
125MP0003795_abnormal_bone_structure0.73978506
126MP0004019_abnormal_vitamin_homeostasis0.73674500
127MP0000230_abnormal_systemic_arterial0.73547495
128MP0001958_emphysema0.73085790
129MP0002060_abnormal_skin_morphology0.72767356
130MP0001299_abnormal_eye_distance/0.71824737
131MP0000604_amyloidosis0.70909826
132MP0001614_abnormal_blood_vessel0.70490069
133MP0003938_abnormal_ear_development0.70255964
134MP0000538_abnormal_urinary_bladder0.70061888
135MP0001177_atelectasis0.69087024
136MP0000003_abnormal_adipose_tissue0.68387877
137MP0001270_distended_abdomen0.68144627
138MP0004036_abnormal_muscle_relaxation0.67596777
139MP0002128_abnormal_blood_circulation0.67569070
140MP0003283_abnormal_digestive_organ0.66842535
141MP0003690_abnormal_glial_cell0.66477395
142MP0009115_abnormal_fat_cell0.65395273
143MP0004130_abnormal_muscle_cell0.65072718
144MP0004484_altered_response_of0.64844303
145MP0000759_abnormal_skeletal_muscle0.64821244
146MP0005367_renal/urinary_system_phenotyp0.64202860
147MP0000516_abnormal_urinary_system0.64202860
148MP0003045_fibrosis0.63965462
149MP0002932_abnormal_joint_morphology0.61484693
150MP0005171_absent_coat_pigmentation0.61292825
151MP0005390_skeleton_phenotype0.60942302
152MP0002136_abnormal_kidney_physiology0.59928552
153MP0008775_abnormal_heart_ventricle0.59187883
154MP0000733_abnormal_muscle_development0.58413297
155MP0010329_abnormal_lipoprotein_level0.58381635
156MP0000377_abnormal_hair_follicle0.57614838
157MP0009643_abnormal_urine_homeostasis0.57557855
158MP0005166_decreased_susceptibility_to0.57282751
159MP0001175_abnormal_lung_morphology0.57066185
160MP0010155_abnormal_intestine_physiology0.56963034
161MP0003329_amyloid_beta_deposits0.56544760
162MP0002109_abnormal_limb_morphology0.56422130
163MP0000490_abnormal_crypts_of0.55947535
164MP0000631_abnormal_neuroendocrine_gland0.54341469
165MP0003950_abnormal_plasma_membrane0.53967990
166MP0003119_abnormal_digestive_system0.53397743
167MP0003385_abnormal_body_wall0.53004848
168MP0003453_abnormal_keratinocyte_physiol0.52748112
169MP0002653_abnormal_ependyma_morphology0.51526659
170MP0003075_altered_response_to0.51141401
171MP0002102_abnormal_ear_morphology0.50530688

Predicted human phenotypes

RankGene SetZ-score
1Goiter (HP:0000853)8.91856977
2Pili torti (HP:0003777)8.20589211
3Protrusio acetabuli (HP:0003179)6.84020632
4Premature rupture of membranes (HP:0001788)5.81480357
5Aortic aneurysm (HP:0004942)5.64282815
6Thyroid-stimulating hormone excess (HP:0002925)5.63403022
7Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)5.02422934
8Onycholysis (HP:0001806)4.61866445
9Abnormal hair laboratory examination (HP:0003328)4.61472547
10Hyperphosphatemia (HP:0002905)4.31265334
11Right ventricular cardiomyopathy (HP:0011663)4.25295314
12Epiphyseal dysplasia (HP:0002656)4.13454257
13Ankle contracture (HP:0006466)3.92055438
14Soft skin (HP:0000977)3.72305138
15Type 1 muscle fiber predominance (HP:0003803)3.63749551
16Tetany (HP:0001281)3.59899872
17Wormian bones (HP:0002645)3.53231174
18Vertebral compression fractures (HP:0002953)3.49762164
19Bladder diverticulum (HP:0000015)3.47861722
20Dilatation of the ascending aorta (HP:0005111)3.41178723
21Spinal rigidity (HP:0003306)3.32570714
22Osteolytic defects of the phalanges of the hand (HP:0009771)3.22441621
23Osteolytic defects of the hand bones (HP:0009699)3.22441621
24Broad metatarsal (HP:0001783)3.21195887
25Abnormality of glutamine family amino acid metabolism (HP:0010902)3.17701512
26Spondylolisthesis (HP:0003302)3.12418345
27Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.08953427
28Peritonitis (HP:0002586)3.06508513
29Atrophic scars (HP:0001075)2.99008982
30Abnormality of proline metabolism (HP:0010907)2.96809641
31Hydroxyprolinuria (HP:0003080)2.96809641
32Cervical subluxation (HP:0003308)2.95168458
33Increased variability in muscle fiber diameter (HP:0003557)2.92157363
34Aortic regurgitation (HP:0001659)2.91613984
35Abnormality of the middle phalanges of the toes (HP:0010183)2.91148652
36Vitreoretinal degeneration (HP:0000655)2.89183746
37Systemic lupus erythematosus (HP:0002725)2.86002527
38Hypoplastic ischia (HP:0003175)2.85235078
39Partial duplication of thumb phalanx (HP:0009944)2.83545651
40Humeroradial synostosis (HP:0003041)2.82432094
41Synostosis involving the elbow (HP:0003938)2.82432094
42Cerebral aneurysm (HP:0004944)2.80230186
43Milia (HP:0001056)2.80006073
44Hypothyroidism (HP:0000821)2.73373986
45Increased connective tissue (HP:0009025)2.70703460
46Neonatal short-limb short stature (HP:0008921)2.70394992
47Genu recurvatum (HP:0002816)2.69820613
48Aneurysm (HP:0002617)2.69379873
49Fragile nails (HP:0001808)2.68697940
50Shallow orbits (HP:0000586)2.68515843
51Aplasia involving bones of the upper limbs (HP:0009823)2.67200078
52Aplasia of the phalanges of the hand (HP:0009802)2.67200078
53Aplasia involving bones of the extremities (HP:0009825)2.67200078
54Mildly elevated creatine phosphokinase (HP:0008180)2.66557948
55Bell-shaped thorax (HP:0001591)2.65737605
56Blue sclerae (HP:0000592)2.65295722
57Partial duplication of the phalanx of hand (HP:0009999)2.64628523
58Slender build (HP:0001533)2.64263014
59Abnormality of complement system (HP:0005339)2.63729926
60Thin bony cortex (HP:0002753)2.62061788
61Overgrowth (HP:0001548)2.61592702
62Mitral valve prolapse (HP:0001634)2.58287325
63Flat acetabular roof (HP:0003180)2.57095758
64Joint stiffness (HP:0001387)2.55734838
65Bronchomalacia (HP:0002780)2.55646914
66Cupped ribs (HP:0000887)2.54511778
67Abnormality of the ischium (HP:0003174)2.52219167
68Aortic valve stenosis (HP:0001650)2.52153160
69Megalencephaly (HP:0001355)2.48310407
70Striae distensae (HP:0001065)2.45881744
71Hyperextensible skin (HP:0000974)2.45066926
72Hypoparathyroidism (HP:0000829)2.44791377
73Abnormality of skeletal muscle fiber size (HP:0012084)2.43224310
74Joint laxity (HP:0001388)2.43103883
75Complement deficiency (HP:0004431)2.40682962
76Thyroid carcinoma (HP:0002890)2.35105084
77Coarse facial features (HP:0000280)2.33089548
78Woolly hair (HP:0002224)2.33001426
79Split foot (HP:0001839)2.31793417
80Ovoid vertebral bodies (HP:0003300)2.30641805
81Mitral regurgitation (HP:0001653)2.30302496
82Biconcave vertebral bodies (HP:0004586)2.27964121
83Germ cell neoplasia (HP:0100728)2.20929281
84Mitral stenosis (HP:0001718)2.20712547
85Arterial tortuosity (HP:0005116)2.18423978
86Emphysema (HP:0002097)2.17018482
87Interstitial pulmonary disease (HP:0006530)2.15135899
88Asymmetry of the thorax (HP:0001555)2.11806172
89Abnormality of cochlea (HP:0000375)2.11551166
90Round ear (HP:0100830)2.11451569
91Abnormality of the acetabulum (HP:0003170)2.11176043
92Wrist flexion contracture (HP:0001239)2.10347780
93Aplasia cutis congenita (HP:0001057)2.09974376
94Nasolacrimal duct obstruction (HP:0000579)2.06618676
95Abnormality of dentin (HP:0010299)2.03881757
96Abnormal vertebral ossification (HP:0100569)2.03747799
97Flared iliac wings (HP:0002869)2.03103658
98Bowel diverticulosis (HP:0005222)2.02417186
99Mixed hearing impairment (HP:0000410)2.01560411
100Camptodactyly of toe (HP:0001836)2.00017259
101Urinary glycosaminoglycan excretion (HP:0003541)1.99763593
102Mucopolysacchariduria (HP:0008155)1.99763593
103Rectal prolapse (HP:0002035)1.99143527
104Asymmetric septal hypertrophy (HP:0001670)1.99066920
105Mesomelia (HP:0003027)1.98501544
106Delayed closure of the anterior fontanelle (HP:0001476)1.97790432
107Abnormality of the lacrimal duct (HP:0011481)1.96991922
108Wide anterior fontanel (HP:0000260)1.95650133
109Abnormality of molar morphology (HP:0011070)1.95255882
110Abnormality of molar (HP:0011077)1.95255882
111Coronal craniosynostosis (HP:0004440)1.93823922
112Hypoplasia of the iris (HP:0007676)1.92351607
113Broad ribs (HP:0000885)1.92230529
114Ectopia lentis (HP:0001083)1.91866737
115Vascular tortuosity (HP:0004948)1.91562759
116Malnutrition (HP:0004395)1.91280304
117Abnormality of the distal phalanx of the thumb (HP:0009617)1.90808566
118Short middle phalanx of finger (HP:0005819)1.89632096
119Persistence of primary teeth (HP:0006335)1.89257013
120Polycythemia (HP:0001901)1.88334121
121Abnormal delivery (HP:0001787)1.87882139
122Mild short stature (HP:0003502)1.86462218
123Abnormality of polysaccharide metabolism (HP:0011012)1.85608564
124Abnormality of glycosaminoglycan metabolism (HP:0004371)1.85608564
125Abnormality of mucopolysaccharide metabolism (HP:0011020)1.85608564
126Elbow flexion contracture (HP:0002987)1.85497551
127Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.85468202
128Short 4th metacarpal (HP:0010044)1.85468202
129Abnormality of permanent molar morphology (HP:0011071)1.84987132
130Abnormality of the dental root (HP:0006486)1.84987132
131Taurodontia (HP:0000679)1.84987132
132Dysostosis multiplex (HP:0000943)1.84798874
133Absent frontal sinuses (HP:0002688)1.83369006
134Umbilical hernia (HP:0001537)1.82845166
135Hypoventilation (HP:0002791)1.82270844
136Hypoplasia of the odontoid process (HP:0003311)1.81920221
137Cardiovascular calcification (HP:0011915)1.81862706
138Coxa vara (HP:0002812)1.80464468
139Turricephaly (HP:0000262)1.80310192
140Vertebral hypoplasia (HP:0008417)1.78803271
141Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.78803271
142Abnormality of the middle phalanges of the hand (HP:0009833)1.78266030
143Morphological abnormality of the inner ear (HP:0011390)1.78229382
144Abnormality of the nasolacrimal system (HP:0000614)1.78113038
145Genu varum (HP:0002970)1.76255029
146Irregular epiphyses (HP:0010582)1.75518474
147Skin nodule (HP:0200036)1.74923949
148Spinal cord lesions (HP:0100561)1.74713970
149Syringomyelia (HP:0003396)1.74713970
150Abnormality of the dental pulp (HP:0006479)1.74620251
151Abnormality of the pubic bones (HP:0003172)1.74469758
152Follicular hyperkeratosis (HP:0007502)1.74120222
153Platyspondyly (HP:0000926)1.73843011
154Redundant skin (HP:0001582)1.73727603
155Abnormality of the phalanges of the 2nd finger (HP:0009541)1.73147073
156Hypoplasia of dental enamel (HP:0006297)1.73091322
157Abnormality of the costochondral junction (HP:0000919)1.72753853
158Delayed cranial suture closure (HP:0000270)1.72487704
159Chondrocalcinosis (HP:0000934)1.71381649
160Hyperactive renin-angiotensin system (HP:0000841)1.70149785
161Barrel-shaped chest (HP:0001552)1.69436596
162Constipation (HP:0002019)1.68352904
163Hypoplastic labia majora (HP:0000059)1.68178602
164Nephritis (HP:0000123)1.66573065
165Abnormality of skull ossification (HP:0002703)1.66187273
166Abnormality of Sharpey fibers (HP:0100685)1.65723696
167Mesangial abnormality (HP:0001966)1.65653780
168Short hallux (HP:0010109)1.64438515
169Aortic dissection (HP:0002647)1.64384509
170Ileus (HP:0002595)1.64276205
171Respiratory distress (HP:0002098)1.64274208
172Abnormality of the parietal bone (HP:0002696)1.64182645
173Bradycardia (HP:0001662)1.64067387
174Preaxial foot polydactyly (HP:0001841)1.64040375
175Morphological abnormality of the middle ear (HP:0008609)1.63836816
176Flattened epiphyses (HP:0003071)1.63271935
177Bifid scrotum (HP:0000048)1.63156285
178Gingival overgrowth (HP:0000212)1.62870764
179Abnormality of carpal bone ossification (HP:0006257)1.61146058
180Pulmonary artery stenosis (HP:0004415)1.59861805
181Deviation of the hallux (HP:0010051)1.59562647
182Synostosis of carpal bones (HP:0005048)1.59505354
183Fragile skin (HP:0001030)1.59491359
184Osteoarthritis (HP:0002758)1.58737542
185Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.57761347
186Abnormality of the 4th metacarpal (HP:0010012)1.57475076

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERBB48.46363568
2MST44.24750608
3LMTK24.20197924
4DDR23.76343694
5LATS13.01516559
6EPHB22.42124435
7TRIB32.40090680
8MST1R2.30161345
9TTN2.10905389
10KIT2.07589414
11FER2.04621036
12PKN21.96773328
13CASK1.78910765
14EPHB11.70559971
15SIK11.68310895
16NUAK11.65054566
17PAK21.64810613
18CDC42BPA1.64766564
19MAP3K61.64325512
20PTK61.62843384
21EPHA31.51406681
22ERBB31.41715170
23MAPK71.38452038
24BCKDK1.37882270
25FGFR11.37465599
26FRK1.36671290
27PRKD21.35555202
28PIK3CG1.32407588
29PAK41.29529213
30FGFR21.27702834
31ACVR1B1.27116629
32PRKG21.25399915
33BMX1.25164239
34RIPK11.24302080
35TYK21.21812489
36ABL21.21358962
37PRPF4B1.18670640
38FGFR41.17756992
39NEK11.16791323
40STK381.14081137
41NEK91.13581397
42PAK31.13230248
43STK38L1.12043398
44GRK51.11082135
45ERBB21.06580916
46ROCK21.06378728
47DYRK1B1.00619905
48LRRK21.00558272
49ROCK10.96145803
50MET0.95137952
51MOS0.94251137
52MAP2K20.93781156
53PRKCI0.92253710
54RPS6KA20.91336103
55MAP3K130.88487844
56MAP2K10.88012860
57EPHA20.87812066
58STK240.85753579
59PTK20.84571337
60LIMK10.84540792
61TRPM70.82443810
62STK30.81950637
63JAK30.79210676
64NTRK20.73939016
65MAP3K140.72927445
66GRK70.72476187
67MAP3K70.71782220
68MAPK120.71434152
69PHKG20.70739205
70PHKG10.70739205
71PRKAA20.70367346
72AKT30.70361898
73PDK20.70177219
74MAP2K30.67699239
75ZAP700.67155012
76BCR0.66208059
77PIK3CA0.66172339
78PDPK10.65309980
79PRKD10.64348192
80PDGFRA0.63543962
81FYN0.62842657
82ERN10.62527259
83RET0.62231918
84IRAK30.62173590
85MAPK40.61670032
86DAPK20.61319427
87MAPKAPK30.61242626
88TIE10.61166647
89MAP3K20.61085664
90SRC0.60751351
91DMPK0.59475629
92NEK60.59454503
93TESK10.59362554
94PRKCE0.59057511
95TBK10.58405712
96EEF2K0.57801995
97STK100.55532321
98YES10.54706477
99CHUK0.54598412
100CDK60.52970503
101FLT30.52082967
102PDGFRB0.51985837
103DAPK30.51609628
104MUSK0.51474904
105RPS6KC10.50952451
106RPS6KL10.50952451
107MAPKAPK20.47802541
108GRK60.46777041
109GRK10.46753633
110PTK2B0.46710489
111MTOR0.45365207
112IRAK10.45350830
113TGFBR20.44199660
114MELK0.44032282
115NLK0.42208954
116CSNK1A1L0.41507362
117KSR10.40281774
118HIPK20.40160532
119PLK20.39508428
120MARK20.39373872
121PRKCD0.38882320
122RPS6KA60.38578090
123WNK10.38021133
124ADRBK20.37464347
125PDK40.36644150
126PDK30.36644150
127MAP3K30.36287791
128FGFR30.35711797
129ILK0.33078934
130NTRK10.32780301
131CAMK1D0.32661216
132GSK3A0.32111644
133MYLK0.31799104
134IGF1R0.31587440
135CSNK1A10.27242514
136ADRBK10.27105559
137CSK0.24574091
138EGFR0.24559496
139CAMKK10.24321701
140LATS20.23231677
141STK390.23201096
142INSR0.22701849
143ABL10.22632686
144PRKG10.22269934
145AKT20.21873468
146PRKCZ0.21060594
147JAK10.20962041
148MATK0.20757968
149PIM20.19121615

Predicted pathways (KEGG)

RankGene SetZ-score
1Autoimmune thyroid disease_Homo sapiens_hsa053205.04873492
2Thyroid hormone synthesis_Homo sapiens_hsa049183.75728747
3Sulfur metabolism_Homo sapiens_hsa009203.44445390
4Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005123.15037975
5Gastric acid secretion_Homo sapiens_hsa049713.11510576
6Renin-angiotensin system_Homo sapiens_hsa046142.79445105
7Cyanoamino acid metabolism_Homo sapiens_hsa004602.47660402
8Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.17200993
9ECM-receptor interaction_Homo sapiens_hsa045122.11335976
10Basal cell carcinoma_Homo sapiens_hsa052171.90215446
11Protein digestion and absorption_Homo sapiens_hsa049741.59974266
12Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.59594657
13Histidine metabolism_Homo sapiens_hsa003401.57515174
14* Mineral absorption_Homo sapiens_hsa049781.57476005
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.55978587
16Glutathione metabolism_Homo sapiens_hsa004801.55230098
17Malaria_Homo sapiens_hsa051441.52330366
18Hippo signaling pathway_Homo sapiens_hsa043901.51873806
19Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.51087826
20Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.46261187
21Chemical carcinogenesis_Homo sapiens_hsa052041.45806916
22Adherens junction_Homo sapiens_hsa045201.45605252
23Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.34269342
24Other glycan degradation_Homo sapiens_hsa005111.28639112
25Thyroid cancer_Homo sapiens_hsa052161.26496621
26Complement and coagulation cascades_Homo sapiens_hsa046101.23571865
27Glycosaminoglycan degradation_Homo sapiens_hsa005311.22727068
28Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.21913623
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.18625894
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.17851979
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.17653258
32Fat digestion and absorption_Homo sapiens_hsa049751.17276762
33Staphylococcus aureus infection_Homo sapiens_hsa051501.15690482
34Nitrogen metabolism_Homo sapiens_hsa009101.14897214
35Pertussis_Homo sapiens_hsa051331.14016407
36Focal adhesion_Homo sapiens_hsa045101.13048136
37Proteoglycans in cancer_Homo sapiens_hsa052051.11017200
38Tight junction_Homo sapiens_hsa045301.06857195
39Bladder cancer_Homo sapiens_hsa052191.04382442
40Galactose metabolism_Homo sapiens_hsa000521.02154058
41Small cell lung cancer_Homo sapiens_hsa052221.02125938
42Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.00842945
43Hedgehog signaling pathway_Homo sapiens_hsa043400.99294097
44Melanogenesis_Homo sapiens_hsa049160.97717622
45AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.97150843
46Dorso-ventral axis formation_Homo sapiens_hsa043200.96757835
47Bile secretion_Homo sapiens_hsa049760.96473598
48Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.94269391
49Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.94074022
50Adipocytokine signaling pathway_Homo sapiens_hsa049200.93280789
51Axon guidance_Homo sapiens_hsa043600.92030916
52Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.91238279
53Tyrosine metabolism_Homo sapiens_hsa003500.89773916
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.88347692
55Glycerolipid metabolism_Homo sapiens_hsa005610.87776692
56Vitamin digestion and absorption_Homo sapiens_hsa049770.84691579
57Wnt signaling pathway_Homo sapiens_hsa043100.83741278
58TGF-beta signaling pathway_Homo sapiens_hsa043500.82780184
59Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.80133892
60Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.78967934
61Leukocyte transendothelial migration_Homo sapiens_hsa046700.76959682
62Phenylalanine metabolism_Homo sapiens_hsa003600.76003313
63Phospholipase D signaling pathway_Homo sapiens_hsa040720.75838769
64Insulin resistance_Homo sapiens_hsa049310.74005662
65Amoebiasis_Homo sapiens_hsa051460.73383305
66Pentose and glucuronate interconversions_Homo sapiens_hsa000400.72987680
67Phagosome_Homo sapiens_hsa041450.71642094
68Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.70116640
69Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69813852
70Endometrial cancer_Homo sapiens_hsa052130.69685739
71Ether lipid metabolism_Homo sapiens_hsa005650.69364839
72Fatty acid biosynthesis_Homo sapiens_hsa000610.69103985
73Pancreatic secretion_Homo sapiens_hsa049720.68426398
74Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.67443852
75Pathways in cancer_Homo sapiens_hsa052000.67117808
76Gap junction_Homo sapiens_hsa045400.66818392
77Prion diseases_Homo sapiens_hsa050200.66640572
78Platelet activation_Homo sapiens_hsa046110.65702780
79Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.65292648
80Linoleic acid metabolism_Homo sapiens_hsa005910.64997172
81Tryptophan metabolism_Homo sapiens_hsa003800.64219842
82ABC transporters_Homo sapiens_hsa020100.63397615
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.62713966
84Lysosome_Homo sapiens_hsa041420.60991765
85Viral myocarditis_Homo sapiens_hsa054160.60810379
86Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.59335433
87Aldosterone synthesis and secretion_Homo sapiens_hsa049250.58541766
88Toxoplasmosis_Homo sapiens_hsa051450.58180336
89Sphingolipid metabolism_Homo sapiens_hsa006000.57969124
90PPAR signaling pathway_Homo sapiens_hsa033200.57540212
91Salivary secretion_Homo sapiens_hsa049700.56151960
92MicroRNAs in cancer_Homo sapiens_hsa052060.55505774
93Arginine biosynthesis_Homo sapiens_hsa002200.54893151
94Arachidonic acid metabolism_Homo sapiens_hsa005900.54721868
95Rap1 signaling pathway_Homo sapiens_hsa040150.53498557
96Caffeine metabolism_Homo sapiens_hsa002320.51987849
97Melanoma_Homo sapiens_hsa052180.51461128
98Ovarian steroidogenesis_Homo sapiens_hsa049130.50043530
99Osteoclast differentiation_Homo sapiens_hsa043800.49697510
100Prostate cancer_Homo sapiens_hsa052150.49144599
101Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48871294
102Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.48604766
103Dilated cardiomyopathy_Homo sapiens_hsa054140.48074823
104African trypanosomiasis_Homo sapiens_hsa051430.47013888
105Fatty acid degradation_Homo sapiens_hsa000710.46941876
106cGMP-PKG signaling pathway_Homo sapiens_hsa040220.46205604
107Fructose and mannose metabolism_Homo sapiens_hsa000510.45515092
108AMPK signaling pathway_Homo sapiens_hsa041520.44376489
109PI3K-Akt signaling pathway_Homo sapiens_hsa041510.43925626
110Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.43759525
111Carbohydrate digestion and absorption_Homo sapiens_hsa049730.43496295
112Renin secretion_Homo sapiens_hsa049240.42269335
113Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41952011
114Leishmaniasis_Homo sapiens_hsa051400.39999023
115Jak-STAT signaling pathway_Homo sapiens_hsa046300.38984579
116Pancreatic cancer_Homo sapiens_hsa052120.38863775
117Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38449954
118Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.38282993
119Glioma_Homo sapiens_hsa052140.38127972
120Colorectal cancer_Homo sapiens_hsa052100.37654009
121Retinol metabolism_Homo sapiens_hsa008300.37512086
122Vibrio cholerae infection_Homo sapiens_hsa051100.36883830
123Vascular smooth muscle contraction_Homo sapiens_hsa042700.36350528
124Estrogen signaling pathway_Homo sapiens_hsa049150.32931558
125Notch signaling pathway_Homo sapiens_hsa043300.31560455
126Chronic myeloid leukemia_Homo sapiens_hsa052200.31188180
127cAMP signaling pathway_Homo sapiens_hsa040240.31037663
128Fatty acid metabolism_Homo sapiens_hsa012120.30521156
129Ras signaling pathway_Homo sapiens_hsa040140.30366496
130TNF signaling pathway_Homo sapiens_hsa046680.29150112
131GnRH signaling pathway_Homo sapiens_hsa049120.28014150
132Olfactory transduction_Homo sapiens_hsa047400.25918518
133Renal cell carcinoma_Homo sapiens_hsa052110.25469282
134Hepatitis C_Homo sapiens_hsa051600.24712465
135Sphingolipid signaling pathway_Homo sapiens_hsa040710.24558139
136N-Glycan biosynthesis_Homo sapiens_hsa005100.24552685
137Starch and sucrose metabolism_Homo sapiens_hsa005000.23195547

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