CYC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a subunit of the cytochrome bc1 complex, which plays an important role in the mitochondrial respiratory chain by transferring electrons from the Rieske iron-sulfur protein to cytochrome c. Mutations in this gene may cause mitochondrial complex III deficiency, nuclear type 6. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tricarboxylic acid cycle (GO:0006099)6.43603315
2oxidative phosphorylation (GO:0006119)5.82805646
3proline biosynthetic process (GO:0006561)5.41668255
4lysine metabolic process (GO:0006553)5.22338834
5lysine catabolic process (GO:0006554)5.22338834
6mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.19856973
7carnitine shuttle (GO:0006853)4.87618210
8NADH metabolic process (GO:0006734)4.78789299
9protein maturation by protein folding (GO:0022417)4.78508059
10energy coupled proton transport, down electrochemical gradient (GO:0015985)4.75056991
11ATP synthesis coupled proton transport (GO:0015986)4.75056991
12sarcomere organization (GO:0045214)4.72820790
13proline metabolic process (GO:0006560)4.64466137
14deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.51288211
15fatty acid transmembrane transport (GO:1902001)4.47220039
162-oxoglutarate metabolic process (GO:0006103)4.47098479
17aspartate family amino acid catabolic process (GO:0009068)4.36447843
18transcription from mitochondrial promoter (GO:0006390)4.34164659
19regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.34137589
20negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.30124679
21fatty acid beta-oxidation (GO:0006635)4.24605618
22GDP-mannose metabolic process (GO:0019673)4.23883272
23COPI coating of Golgi vesicle (GO:0048205)4.23060824
24Golgi transport vesicle coating (GO:0048200)4.23060824
25regulation of mitochondrial translation (GO:0070129)4.21760424
26peptidyl-arginine omega-N-methylation (GO:0035247)4.14528942
27cardiac myofibril assembly (GO:0055003)4.13404987
28glyoxylate metabolic process (GO:0046487)4.06895789
29nucleobase-containing small molecule interconversion (GO:0015949)4.04679728
30* respiratory electron transport chain (GO:0022904)4.02693302
31acetyl-CoA metabolic process (GO:0006084)3.99617618
32actin-myosin filament sliding (GO:0033275)3.99301906
33muscle filament sliding (GO:0030049)3.99301906
34negative regulation of fatty acid biosynthetic process (GO:0045717)3.97735707
35negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.96727813
36DNA unwinding involved in DNA replication (GO:0006268)3.96352548
37DNA deamination (GO:0045006)3.92343013
38* electron transport chain (GO:0022900)3.90609340
39regulation of acyl-CoA biosynthetic process (GO:0050812)3.90308961
40branched-chain amino acid catabolic process (GO:0009083)3.89064490
41tricarboxylic acid metabolic process (GO:0072350)3.87110974
42regulation of cofactor metabolic process (GO:0051193)3.84858812
43regulation of coenzyme metabolic process (GO:0051196)3.84858812
44formation of translation preinitiation complex (GO:0001731)3.80052061
45negative regulation of potassium ion transmembrane transport (GO:1901380)3.79380569
46ribosomal small subunit biogenesis (GO:0042274)3.77301838
47cardiac muscle contraction (GO:0060048)3.76045228
48oxaloacetate metabolic process (GO:0006107)3.75879623
49cardiac muscle cell development (GO:0055013)3.70692249
50carnitine transmembrane transport (GO:1902603)3.69955645
51carnitine transport (GO:0015879)3.66041923
52amino-acid betaine transport (GO:0015838)3.66041923
53succinate metabolic process (GO:0006105)3.64191797
54branched-chain amino acid metabolic process (GO:0009081)3.62017408
55mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.59989548
56mitochondrial fusion (GO:0008053)3.58084088
57fatty acid oxidation (GO:0019395)3.56594502
58fatty acid catabolic process (GO:0009062)3.56385975
59myofibril assembly (GO:0030239)3.53905612
60sulfur amino acid catabolic process (GO:0000098)3.52991292
61DNA strand elongation involved in DNA replication (GO:0006271)3.48173231
62lipid oxidation (GO:0034440)3.47768358
63biotin metabolic process (GO:0006768)3.47379626
64protein retention in ER lumen (GO:0006621)3.46517645
65histone arginine methylation (GO:0034969)3.45952075
66monosaccharide biosynthetic process (GO:0046364)3.43794520
67cardiac cell development (GO:0055006)3.42211782
68DNA strand elongation (GO:0022616)3.39070846
69cellular ketone body metabolic process (GO:0046950)3.37634631
70establishment of integrated proviral latency (GO:0075713)3.33818537
71valine metabolic process (GO:0006573)3.33013914
72nuclear envelope reassembly (GO:0031468)3.32775446
73mitotic nuclear envelope reassembly (GO:0007084)3.32775446
74short-chain fatty acid metabolic process (GO:0046459)3.29221979
75regulation of fatty acid oxidation (GO:0046320)3.28203191
76negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.26569557
77maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.26070093
78pentose-phosphate shunt (GO:0006098)3.24751336
79carnitine metabolic process (GO:0009437)3.21746588
80telomere maintenance via semi-conservative replication (GO:0032201)3.19885077
81erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.19836992
82L-phenylalanine metabolic process (GO:0006558)3.19836992
83peptidyl-arginine N-methylation (GO:0035246)3.19274692
84peptidyl-arginine methylation (GO:0018216)3.19274692
85negative regulation of fatty acid metabolic process (GO:0045922)3.15228872
86ATP biosynthetic process (GO:0006754)3.13837256
87regulation of sequestering of triglyceride (GO:0010889)3.12717527
88amino-acid betaine metabolic process (GO:0006577)3.11600657
89monocarboxylic acid catabolic process (GO:0072329)3.11314210
90negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.10262298
91mitochondrial DNA metabolic process (GO:0032042)3.10107509
92positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.09919399
93regulation of skeletal muscle contraction (GO:0014819)3.08945107
94ventricular cardiac muscle cell action potential (GO:0086005)3.08900607
95bundle of His cell to Purkinje myocyte communication (GO:0086069)3.08818176
96regulation of mammary gland epithelial cell proliferation (GO:0033599)3.07633543
97actin-mediated cell contraction (GO:0070252)3.07322622
98establishment of viral latency (GO:0019043)3.07125893
99cardiac muscle tissue morphogenesis (GO:0055008)3.04363283
100ubiquinone biosynthetic process (GO:0006744)3.03661564
101quinone biosynthetic process (GO:1901663)3.03661564
102establishment of protein localization to mitochondrial membrane (GO:0090151)3.01335321
103ribonucleoprotein complex biogenesis (GO:0022613)3.00118696
104quaternary ammonium group transport (GO:0015697)2.99324350
105glycolytic process (GO:0006096)2.97792969
106glucose catabolic process (GO:0006007)2.96930731
107glutamine family amino acid biosynthetic process (GO:0009084)2.96881341
108retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.96770049
109protein targeting to mitochondrion (GO:0006626)2.96639154
110regulation of sulfur metabolic process (GO:0042762)2.96502741
111glycine metabolic process (GO:0006544)2.96461050
112guanosine-containing compound biosynthetic process (GO:1901070)2.96286484
113mitochondrial RNA metabolic process (GO:0000959)2.96143572
114regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.95623864
115negative regulation of ligase activity (GO:0051352)2.95592269
116negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.95592269
117creatine metabolic process (GO:0006600)2.94986062
118ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.94590205
119cysteine metabolic process (GO:0006534)2.94510542
120regulation of translational termination (GO:0006449)2.94047514
121gluconeogenesis (GO:0006094)2.93735680
122maturation of SSU-rRNA (GO:0030490)2.92607195
123pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.92228397
124ribosome biogenesis (GO:0042254)2.91584084
125ketone body metabolic process (GO:1902224)2.90990945
126serine family amino acid catabolic process (GO:0009071)2.90302802
127pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.90170608
128regulation of translational fidelity (GO:0006450)2.87895465
129DNA replication initiation (GO:0006270)2.87589724
130deoxyribose phosphate biosynthetic process (GO:0046385)2.87017611
1312-deoxyribonucleotide biosynthetic process (GO:0009265)2.87017611
132plasma membrane repair (GO:0001778)2.86375575
133mitotic chromosome condensation (GO:0007076)2.86133715
134folic acid metabolic process (GO:0046655)2.85637334
135nucleoside diphosphate biosynthetic process (GO:0009133)2.85099297
1364-hydroxyproline metabolic process (GO:0019471)2.85083382
137NADPH regeneration (GO:0006740)2.84862790
138pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.84778191
139nucleotide salvage (GO:0043173)2.84677393
140actomyosin structure organization (GO:0031032)2.84627260
141anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.84530319
142kynurenine metabolic process (GO:0070189)2.84324770
143regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.83649928
144positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.82999482
145striated muscle contraction (GO:0006941)2.80560236
146ribosomal large subunit biogenesis (GO:0042273)2.79689861
147negative regulation of cell size (GO:0045792)2.79581025
148regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.78915654
149ribosome assembly (GO:0042255)2.78255443
150viral transcription (GO:0019083)2.77770641
151heart process (GO:0003015)2.77061963
152heart contraction (GO:0060047)2.77061963
153heart trabecula formation (GO:0060347)2.76885578
154hexose biosynthetic process (GO:0019319)2.75429212
155galactose catabolic process (GO:0019388)2.74911260
156ethanol oxidation (GO:0006069)2.74234742
157heme biosynthetic process (GO:0006783)2.74051429
158establishment of protein localization to mitochondrion (GO:0072655)2.73768529
159regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.73209643
160proteasome assembly (GO:0043248)2.72777732
161glycogen catabolic process (GO:0005980)2.72550481
162pentose metabolic process (GO:0019321)2.72436442
163iron-sulfur cluster assembly (GO:0016226)2.70337836
164metallo-sulfur cluster assembly (GO:0031163)2.70337836
165deoxyribonucleotide biosynthetic process (GO:0009263)2.69848763
166pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.68751521
167regulation of cellular amino acid metabolic process (GO:0006521)2.68655103
168pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.65833973
169translational elongation (GO:0006414)2.65072940
170UTP biosynthetic process (GO:0006228)2.59638090
171pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.59236411
172regulation of cellular respiration (GO:0043457)2.59094326
173rRNA transcription (GO:0009303)2.59042188
174aerobic respiration (GO:0009060)2.58729275
175positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.58132700
176translational termination (GO:0006415)2.57875881
177pseudouridine synthesis (GO:0001522)2.56052098
178ribosomal small subunit assembly (GO:0000028)2.55961565
179cellular component biogenesis (GO:0044085)2.54255138
180protein localization to mitochondrion (GO:0070585)2.53894629

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.46738458
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.11259901
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.86110936
4* ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.05923394
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.00877183
6RXR_22158963_ChIP-Seq_LIVER_Mouse2.88258331
7PPARA_22158963_ChIP-Seq_LIVER_Mouse2.83950415
8TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.83240009
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.66692673
10ZNF263_19887448_ChIP-Seq_K562_Human2.40320168
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.29745372
12NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.18308097
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.14405629
14STAT3_1855785_ChIP-Seq_MESCs_Mouse2.11494722
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.08271892
16MYC_19079543_ChIP-ChIP_MESCs_Mouse1.95514117
17ETS1_20019798_ChIP-Seq_JURKAT_Human1.92826780
18LXR_22158963_ChIP-Seq_LIVER_Mouse1.88245830
19MYC_19030024_ChIP-ChIP_MESCs_Mouse1.84704378
20FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.81816056
21RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.77915796
22* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.72632585
23CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.66184127
24LXR_22292898_ChIP-Seq_THP-1_Human1.65031287
25SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.64722154
26POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.64472700
27CREB1_15753290_ChIP-ChIP_HEK293T_Human1.62489349
28TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62450250
29E2F7_22180533_ChIP-Seq_HELA_Human1.59199083
30BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.58902259
31KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.58504740
32PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.57610345
33THAP11_20581084_ChIP-Seq_MESCs_Mouse1.57005752
34YY1_21170310_ChIP-Seq_MESCs_Mouse1.55851564
35ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.54869574
36NANOG_18555785_ChIP-Seq_MESCs_Mouse1.49445621
37HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.47950216
38* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.47340288
39ZFX_18555785_ChIP-Seq_MESCs_Mouse1.44626971
40NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.43239626
41KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.42629250
42RARG_19884340_ChIP-ChIP_MEFs_Mouse1.42377249
43* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.42332068
44DCP1A_22483619_ChIP-Seq_HELA_Human1.42127373
45CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.40485155
46* XRN2_22483619_ChIP-Seq_HELA_Human1.39237901
47TET1_21451524_ChIP-Seq_MESCs_Mouse1.37502588
48ELF1_17652178_ChIP-ChIP_JURKAT_Human1.36810274
49GABP_19822575_ChIP-Seq_HepG2_Human1.35554297
50SRF_21415370_ChIP-Seq_HL-1_Mouse1.34476401
51KLF4_18555785_ChIP-Seq_MESCs_Mouse1.33307266
52* VDR_21846776_ChIP-Seq_THP-1_Human1.32978458
53CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.32296453
54TP63_17297297_ChIP-ChIP_HaCaT_Human1.31524494
55TTF2_22483619_ChIP-Seq_HELA_Human1.31325458
56RACK7_27058665_Chip-Seq_MCF-7_Human1.31095369
57ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.29196310
58EST1_17652178_ChIP-ChIP_JURKAT_Human1.28933640
59HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.28921550
60HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.28458940
61CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.25606257
62SRY_22984422_ChIP-ChIP_TESTIS_Rat1.23598401
63GABP_17652178_ChIP-ChIP_JURKAT_Human1.23533978
64CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.23524614
65KDM5A_27292631_Chip-Seq_BREAST_Human1.23369501
66OCT4_18692474_ChIP-Seq_MEFs_Mouse1.22945732
67CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.21769559
68YY1_22570637_ChIP-Seq_MALME-3M_Human1.21632152
69CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.21525699
70P68_20966046_ChIP-Seq_HELA_Human1.20110142
71NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.19464406
72ATF3_27146783_Chip-Seq_COLON_Human1.19260590
73SOX2_18692474_ChIP-Seq_MEFs_Mouse1.18910907
74PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.18852668
75SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.18125832
76SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.17809137
77* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.17532755
78KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.17121762
79CTCF_18555785_ChIP-Seq_MESCs_Mouse1.16242434
80SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.16047807
81CLOCK_20551151_ChIP-Seq_293T_Human1.14938681
82CIITA_25753668_ChIP-Seq_RAJI_Human1.14633681
83FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.14180374
84BCL6_27268052_Chip-Seq_Bcells_Human1.13756919
85CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.13606447
86ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.13576746
87GATA4_21415370_ChIP-Seq_HL-1_Mouse1.13087856
88BCOR_27268052_Chip-Seq_Bcells_Human1.11948844
89* MYC_22102868_ChIP-Seq_BL_Human1.10969661
90SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.10679139
91SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.10410243
92NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.10359812
93DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.09987584
94ESR1_15608294_ChIP-ChIP_MCF-7_Human1.09059173
95* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.08816152
96SA1_27219007_Chip-Seq_ERYTHROID_Human1.08438375
97CTCF_27219007_Chip-Seq_ERYTHROID_Human1.07746811
98NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.07284533
99FOXM1_23109430_ChIP-Seq_U2OS_Human1.06814887
100ERG_20887958_ChIP-Seq_HPC-7_Mouse1.06809866
101POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.06655578
102TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06375464
103* FOXP1_21924763_ChIP-Seq_HESCs_Human1.05566427
104TCF3_18692474_ChIP-Seq_MEFs_Mouse1.04990926
105CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.04570293
106CTCF_26484167_Chip-Seq_Bcells_Mouse1.04559182
107TBX5_21415370_ChIP-Seq_HL-1_Mouse1.04393551
108FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.04233538
109NANOG_21062744_ChIP-ChIP_HESCs_Human1.03945010
110* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.03746988
111ELK3_25401928_ChIP-Seq_HUVEC_Human1.03326380
112NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.03112193
113FOXP3_21729870_ChIP-Seq_TREG_Human1.02524489
114PHF8_20622854_ChIP-Seq_HELA_Human1.02207598
115E2F4_17652178_ChIP-ChIP_JURKAT_Human1.01796438
116POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.00686983
117E2F1_21310950_ChIP-Seq_MCF-7_Human0.99318032
118TBX20_22328084_ChIP-Seq_HEART_Mouse0.98892111
119TBX20_22080862_ChIP-Seq_HEART_Mouse0.98892111
120NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.98296341
121SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.98188384
122TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.96670028
123ZFP281_18757296_ChIP-ChIP_E14_Mouse0.96182563
124SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.95935066
125E2F1_20622854_ChIP-Seq_HELA_Human0.95680029
126TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.95333927
127AR_21909140_ChIP-Seq_LNCAP_Human0.93335322
128ELF1_20517297_ChIP-Seq_JURKAT_Human0.93024850
129SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.92130586
130POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.91598033
131SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.91580242

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.43559689
2MP0003646_muscle_fatigue4.30970861
3MP0004084_abnormal_cardiac_muscle3.85801033
4MP0000751_myopathy3.65410156
5MP0003806_abnormal_nucleotide_metabolis3.60305926
6MP0005330_cardiomyopathy3.46997026
7MP0005360_urolithiasis3.23017970
8MP0004215_abnormal_myocardial_fiber3.21827637
9MP0000749_muscle_degeneration2.88495157
10MP0005085_abnormal_gallbladder_physiolo2.87767030
11MP0006036_abnormal_mitochondrial_physio2.83504607
12MP0002139_abnormal_hepatobiliary_system2.80195514
13MP0004036_abnormal_muscle_relaxation2.75134984
14MP0002269_muscular_atrophy2.56467834
15MP0004233_abnormal_muscle_weight2.50936859
16MP0005365_abnormal_bile_salt2.45368644
17MP0004087_abnormal_muscle_fiber2.44648819
18MP0004130_abnormal_muscle_cell2.36075026
19MP0005058_abnormal_lysosome_morphology2.34597275
20MP0003137_abnormal_impulse_conducting2.31450051
21MP0008775_abnormal_heart_ventricle2.22906110
22MP0003221_abnormal_cardiomyocyte_apopto2.12278635
23MP0010630_abnormal_cardiac_muscle2.08654526
24MP0002877_abnormal_melanocyte_morpholog2.06971155
25MP0008932_abnormal_embryonic_tissue2.03382842
26MP0003077_abnormal_cell_cycle2.02707235
27MP0000750_abnormal_muscle_regeneration2.01713670
28MP0008260_abnormal_autophagy2.00549703
29MP0005332_abnormal_amino_acid1.99586514
30MP0002972_abnormal_cardiac_muscle1.95781578
31MP0001661_extended_life_span1.95196614
32MP0002106_abnormal_muscle_physiology1.87742159
33MP0005385_cardiovascular_system_phenoty1.87094441
34MP0001544_abnormal_cardiovascular_syste1.87094441
35MP0000747_muscle_weakness1.84960349
36MP0010234_abnormal_vibrissa_follicle1.82377107
37MP0005620_abnormal_muscle_contractility1.79648021
38MP0009840_abnormal_foam_cell1.79450621
39MP0005670_abnormal_white_adipose1.77941935
40MP0005666_abnormal_adipose_tissue1.70663710
41MP0006035_abnormal_mitochondrial_morpho1.70643046
42MP0005501_abnormal_skin_physiology1.69396616
43MP0004858_abnormal_nervous_system1.63742558
44MP0005266_abnormal_metabolism1.61704910
45MP0008007_abnormal_cellular_replicative1.58817026
46MP0000003_abnormal_adipose_tissue1.57662014
47MP0000759_abnormal_skeletal_muscle1.56201127
48MP0006138_congestive_heart_failure1.55107480
49MP0003567_abnormal_fetal_cardiomyocyte1.53089254
50MP0004145_abnormal_muscle_electrophysio1.50448845
51MP0008875_abnormal_xenobiotic_pharmacok1.49565419
52MP0000678_abnormal_parathyroid_gland1.47315497
53MP0002332_abnormal_exercise_endurance1.46454331
54MP0005369_muscle_phenotype1.44497995
55MP0005319_abnormal_enzyme/_coenzyme1.43214093
56MP0003705_abnormal_hypodermis_morpholog1.42264648
57MP0002796_impaired_skin_barrier1.42098212
58MP0003828_pulmonary_edema1.40468215
59MP0010329_abnormal_lipoprotein_level1.37056253
60MP0008058_abnormal_DNA_repair1.30059601
61MP0005083_abnormal_biliary_tract1.29061134
62MP0000350_abnormal_cell_proliferation1.25285594
63MP0004185_abnormal_adipocyte_glucose1.22157209
64MP0004484_altered_response_of1.22039943
65MP0010030_abnormal_orbit_morphology1.21125891
66MP0003186_abnormal_redox_activity1.19196339
67MP0009333_abnormal_splenocyte_physiolog1.18643633
68MP0002127_abnormal_cardiovascular_syste1.17996342
69MP0003195_calcinosis1.17927372
70MP0003123_paternal_imprinting1.17506851
71MP0003786_premature_aging1.17099211
72MP0000733_abnormal_muscle_development1.16426726
73MP0003315_abnormal_perineum_morphology1.14522784
74MP0001727_abnormal_embryo_implantation1.14455084
75MP0000537_abnormal_urethra_morphology1.12981471
76MP0004043_abnormal_pH_regulation1.11168822
77MP0000313_abnormal_cell_death1.09678202
78MP0003656_abnormal_erythrocyte_physiolo1.09051838
79MP0004957_abnormal_blastocyst_morpholog1.08442601
80MP0002971_abnormal_brown_adipose1.07783682
81MP0002118_abnormal_lipid_homeostasis1.07391740
82MP0001666_abnormal_nutrient_absorption1.06556002
83MP0005584_abnormal_enzyme/coenzyme_acti1.03662510
84MP0003453_abnormal_keratinocyte_physiol1.02151562
85MP0004085_abnormal_heartbeat1.01879834
86MP0003252_abnormal_bile_duct1.01453539
87MP0000490_abnormal_crypts_of1.01430685
88MP0000609_abnormal_liver_physiology1.01142342
89MP0009643_abnormal_urine_homeostasis0.99019311
90MP0005375_adipose_tissue_phenotype0.98390135
91MP0004019_abnormal_vitamin_homeostasis0.96814697
92MP0003191_abnormal_cellular_cholesterol0.96175247
93MP0000013_abnormal_adipose_tissue0.93599153
94MP0008057_abnormal_DNA_replication0.93316637
95MP0009672_abnormal_birth_weight0.93040110
96MP0000266_abnormal_heart_morphology0.91652737
97MP0000858_altered_metastatic_potential0.90591869
98MP0005165_increased_susceptibility_to0.90128225
99MP0001849_ear_inflammation0.89307443
100MP0001730_embryonic_growth_arrest0.85698948
101MP0001346_abnormal_lacrimal_gland0.84424599
102MP0001764_abnormal_homeostasis0.84367804
103MP0005076_abnormal_cell_differentiation0.83265433
104MP0002019_abnormal_tumor_incidence0.82163254
105MP0003984_embryonic_growth_retardation0.81951563
106MP0000343_altered_response_to0.81426341
107MP0005376_homeostasis/metabolism_phenot0.80589117
108MP0009697_abnormal_copulation0.80550910
109MP0002088_abnormal_embryonic_growth/wei0.79787392
110MP0003693_abnormal_embryo_hatching0.78114365
111MP0004133_heterotaxia0.77844032
112MP0001697_abnormal_embryo_size0.76184752
113MP0002249_abnormal_larynx_morphology0.76026367
114MP0001672_abnormal_embryogenesis/_devel0.75859181
115MP0005380_embryogenesis_phenotype0.75859181
116MP0004147_increased_porphyrin_level0.75469961
117MP0002970_abnormal_white_adipose0.74809618
118MP0005451_abnormal_body_composition0.72839825
119MP0009278_abnormal_bone_marrow0.72224046
120MP0000358_abnormal_cell_content/0.70628543
121MP0002078_abnormal_glucose_homeostasis0.69547621
122MP0001881_abnormal_mammary_gland0.67917748
123MP0000598_abnormal_liver_morphology0.67859117
124MP0003329_amyloid_beta_deposits0.67275631
125MP0009115_abnormal_fat_cell0.66132569
126MP0003283_abnormal_digestive_organ0.66130338
127MP0002060_abnormal_skin_morphology0.64612242
128MP0005384_cellular_phenotype0.64195595
129MP0002822_catalepsy0.64083620
130MP0003566_abnormal_cell_adhesion0.64024811
131MP0002086_abnormal_extraembryonic_tissu0.63895910
132MP0002080_prenatal_lethality0.62970704
133MP0010352_gastrointestinal_tract_polyps0.59634560
134MP0001756_abnormal_urination0.58486380
135MP0003119_abnormal_digestive_system0.58059391
136MP0003111_abnormal_nucleus_morphology0.56463995
137MP0005535_abnormal_body_temperature0.52562691
138MP0010094_abnormal_chromosome_stability0.51227804
139MP0004197_abnormal_fetal_growth/weight/0.48814375

Predicted human phenotypes

RankGene SetZ-score
1Myoglobinuria (HP:0002913)5.06762792
2Sudden death (HP:0001699)4.95764700
3Exercise-induced myalgia (HP:0003738)4.66364026
4Exercise-induced muscle cramps (HP:0003710)4.33017952
5Rhabdomyolysis (HP:0003201)4.26351255
6Ventricular tachycardia (HP:0004756)4.24020862
7Muscle fiber inclusion bodies (HP:0100299)4.08433861
8Nemaline bodies (HP:0003798)4.06715733
9Myopathic facies (HP:0002058)4.04112896
10Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.03718052
11Hepatic necrosis (HP:0002605)3.96799819
12Hyperglycinuria (HP:0003108)3.73551323
13Hypoglycemic coma (HP:0001325)3.70928015
14Palpitations (HP:0001962)3.68183078
15Distal lower limb muscle weakness (HP:0009053)3.66074039
16Abnormality of fatty-acid metabolism (HP:0004359)3.65379440
17Calf muscle hypertrophy (HP:0008981)3.59747640
18Abnormality of dicarboxylic acid metabolism (HP:0010995)3.59287842
19Dicarboxylic aciduria (HP:0003215)3.59287842
20Centrally nucleated skeletal muscle fibers (HP:0003687)3.55623424
21Abnormal mitochondria in muscle tissue (HP:0008316)3.51896490
22Acute encephalopathy (HP:0006846)3.49450679
23Cerebral edema (HP:0002181)3.39734701
24Hepatocellular necrosis (HP:0001404)3.36096797
25Lipoatrophy (HP:0100578)3.33929772
26Muscle hypertrophy of the lower extremities (HP:0008968)3.32335777
27Acute necrotizing encephalopathy (HP:0006965)3.32149606
28* Hyperammonemia (HP:0001987)3.32108638
29Asymmetric septal hypertrophy (HP:0001670)3.31325335
30Increased muscle lipid content (HP:0009058)3.30819305
31Abnormality of serine family amino acid metabolism (HP:0010894)3.20263346
32Abnormality of glycine metabolism (HP:0010895)3.20263346
33Abnormal gallbladder physiology (HP:0012438)3.18305932
34Cholecystitis (HP:0001082)3.18305932
35Muscle fiber splitting (HP:0003555)3.18085033
36Microvesicular hepatic steatosis (HP:0001414)3.13763324
37Right ventricular cardiomyopathy (HP:0011663)3.07957103
38Ragged-red muscle fibers (HP:0003200)3.07526610
39Atrial fibrillation (HP:0005110)3.02418555
40* Ketosis (HP:0001946)3.02405502
41Distal lower limb amyotrophy (HP:0008944)2.92948142
42Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.92268399
43Decreased activity of mitochondrial respiratory chain (HP:0008972)2.92268399
44Increased CSF lactate (HP:0002490)2.91412732
45Dilated cardiomyopathy (HP:0001644)2.90315883
46Increased serum pyruvate (HP:0003542)2.89772965
47Abnormality of glycolysis (HP:0004366)2.89772965
48* Ketoacidosis (HP:0001993)2.88461394
49Mitochondrial inheritance (HP:0001427)2.87802412
50* Lactic acidosis (HP:0003128)2.87270154
51Increased intramyocellular lipid droplets (HP:0012240)2.86044294
52Hyporeflexia of lower limbs (HP:0002600)2.85817576
53Supraventricular tachycardia (HP:0004755)2.85741704
54Lethargy (HP:0001254)2.85638434
55Primary atrial arrhythmia (HP:0001692)2.82781790
56Testicular atrophy (HP:0000029)2.80415703
57Abnormality of the calf musculature (HP:0001430)2.80195470
58Supraventricular arrhythmia (HP:0005115)2.80161486
59Ventricular arrhythmia (HP:0004308)2.77089893
60Type 1 muscle fiber predominance (HP:0003803)2.75939036
61Generalized aminoaciduria (HP:0002909)2.74367303
62Hyperglycinemia (HP:0002154)2.73171715
63Multiple enchondromatosis (HP:0005701)2.71150343
64Subaortic stenosis (HP:0001682)2.70057045
65Abnormality of the left ventricular outflow tract (HP:0011103)2.70057045
66Muscle stiffness (HP:0003552)2.70035347
67Achilles tendon contracture (HP:0001771)2.69664882
68Syncope (HP:0001279)2.67308196
69Nausea (HP:0002018)2.66367360
70Neck muscle weakness (HP:0000467)2.60729915
71Bundle branch block (HP:0011710)2.59517245
72Increased connective tissue (HP:0009025)2.57469763
73Progressive macrocephaly (HP:0004481)2.55214736
74Exercise intolerance (HP:0003546)2.52542246
75Cholelithiasis (HP:0001081)2.49825385
76Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.47603053
77Metabolic acidosis (HP:0001942)2.47554070
78Respiratory failure (HP:0002878)2.47009641
79Conjunctival hamartoma (HP:0100780)2.46529058
80Ventricular fibrillation (HP:0001663)2.43708990
81Abnormality of the Achilles tendon (HP:0005109)2.43045158
82Gout (HP:0001997)2.41984320
83EMG: myopathic abnormalities (HP:0003458)2.41390573
84Myotonia (HP:0002486)2.40908956
85Proximal tubulopathy (HP:0000114)2.40624884
86Atrioventricular block (HP:0001678)2.40485350
87Progressive muscle weakness (HP:0003323)2.39075916
88Pheochromocytoma (HP:0002666)2.35722767
89Trismus (HP:0000211)2.35558492
90Heart block (HP:0012722)2.34800889
91Vomiting (HP:0002013)2.34755743
92CNS demyelination (HP:0007305)2.34038160
93Reticulocytosis (HP:0001923)2.32293246
94Abnormality of alanine metabolism (HP:0010916)2.32176120
95Hyperalaninemia (HP:0003348)2.32176120
96Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.32176120
97Abnormality of aromatic amino acid family metabolism (HP:0004338)2.30502982
98* Increased serum lactate (HP:0002151)2.29345974
99Bulbar palsy (HP:0001283)2.28052371
100Prolonged QT interval (HP:0001657)2.23479058
101Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.22347306
102Vertebral compression fractures (HP:0002953)2.21848780
103Hypobetalipoproteinemia (HP:0003563)2.20814541
104Difficulty climbing stairs (HP:0003551)2.19755638
105Hyperacusis (HP:0010780)2.18699097
106Abnormal atrioventricular conduction (HP:0005150)2.17433238
107Neoplasm of the adrenal gland (HP:0100631)2.16113359
108Neuroendocrine neoplasm (HP:0100634)2.15420132
109Lipid accumulation in hepatocytes (HP:0006561)2.14773291
110Progressive external ophthalmoplegia (HP:0000590)2.14184111
111Diaphragmatic weakness (HP:0009113)2.13390639
112Abnormality of serum amino acid levels (HP:0003112)2.13356942
113Late onset (HP:0003584)2.12449837
114Abnormality of cells of the erythroid lineage (HP:0012130)2.11078335
115Abnormal gallbladder morphology (HP:0012437)2.10092714
116Abnormality of the tricuspid valve (HP:0001702)2.08611846
117Xanthomatosis (HP:0000991)2.07317915
118Difficulty running (HP:0009046)2.06895284
119Abnormality of skeletal muscle fiber size (HP:0012084)2.05147593
120Abnormality of reticulocytes (HP:0004312)2.04290984
121Hypolipoproteinemia (HP:0010981)2.04251150
122Type I transferrin isoform profile (HP:0003642)2.03641202
123Esophageal neoplasm (HP:0100751)2.03448714
124Neoplasm of head and neck (HP:0012288)2.03448714
125Abnormal number of erythroid precursors (HP:0012131)2.01181049
126Athetosis (HP:0002305)2.01100809
127Generalized amyotrophy (HP:0003700)1.99708517
128Rough bone trabeculation (HP:0100670)1.98100712
129Delayed CNS myelination (HP:0002188)1.97674835
130Hypoalphalipoproteinemia (HP:0003233)1.97168327
131Increased hepatocellular lipid droplets (HP:0006565)1.97127792
132Pancreatic islet-cell hyperplasia (HP:0004510)1.96103694
133Mildly elevated creatine phosphokinase (HP:0008180)1.95061560
134Intrahepatic cholestasis (HP:0001406)1.93319304
135Reduced antithrombin III activity (HP:0001976)1.90861203
136Hypokinesia (HP:0002375)1.90621756
137Rimmed vacuoles (HP:0003805)1.90513639
138Hypertensive crisis (HP:0100735)1.85921698
139Insomnia (HP:0100785)1.83401452
140Aplasia/Hypoplasia of the sacrum (HP:0008517)1.82192473
141Microretrognathia (HP:0000308)1.81245080
142Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.80341562
143Fasciculations (HP:0002380)1.80210035
144Lower limb amyotrophy (HP:0007210)1.78109038
145Abnormality of the gallbladder (HP:0005264)1.78074967
146Abnormality of the umbilical cord (HP:0010881)1.77901134
147Calcaneovalgus deformity (HP:0001848)1.77721660
148Round ear (HP:0100830)1.77620327
149Foot dorsiflexor weakness (HP:0009027)1.75158944
150Emotional lability (HP:0000712)1.73877813
151Truncus arteriosus (HP:0001660)1.72100693
152Limb-girdle muscle atrophy (HP:0003797)1.69978212
153Ulnar deviation of the wrist (HP:0003049)1.69167880
154Abnormality of the foot musculature (HP:0001436)1.64159109

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.84582062
2NEK13.57008875
3TRIB33.34363883
4TTN3.14040775
5PINK13.01128612
6PDK32.97299506
7PDK42.97299506
8IRAK32.91981302
9MAP3K112.91625696
10ICK2.90348262
11PKN22.89471078
12OBSCN2.88005907
13PHKG22.86797321
14PHKG12.86797321
15VRK22.80978992
16LMTK22.58627689
17SMG12.51123264
18TESK12.48513259
19ARAF2.11165202
20MYLK2.10026844
21MST1R1.91017778
22MAP3K61.77641165
23EEF2K1.77103924
24DDR21.63132169
25MAPK151.56304448
26LIMK11.56253093
27PDK21.53418768
28PBK1.53296534
29NME21.50611863
30MAPKAPK31.38071871
31KDR1.34539739
32PRPF4B1.32736256
33BUB11.31276677
34SRPK11.21844987
35FLT31.16896347
36LATS21.16762619
37STK161.16516220
38STK38L1.15327243
39MAPK111.12627958
40DAPK11.12166120
41PDGFRA1.12092965
42ERN11.11468157
43WEE11.10760813
44MAP3K101.05436194
45CDC71.03828166
46MAP2K31.02126624
47ILK1.01939141
48DMPK1.01739586
49BRAF1.01509546
50PIM20.99863234
51CDK80.97388480
52CDC42BPA0.93670215
53NME10.93348155
54CCNB10.93339293
55TAOK20.91405867
56PRKAA10.89667373
57WNK40.89086217
58EIF2AK10.88754360
59MATK0.83131843
60STK240.82515403
61UHMK10.81775926
62BMX0.81400466
63DYRK1B0.78603029
64TYRO30.75491250
65SIK10.75288458
66MAP3K50.75153698
67RPS6KC10.71281133
68RPS6KL10.71281133
69CDK70.70792336
70TIE10.70748035
71MAP3K30.68079416
72MET0.66036167
73RPS6KB20.64750654
74DAPK30.64550053
75RIPK10.63812500
76AKT20.62653276
77TESK20.62097089
78TBK10.61575667
79TAOK10.61132565
80TTK0.60953765
81BRSK10.60560034
82CAMK2D0.59969952
83CHEK20.59789090
84PRKD10.59080549
85RPS6KA60.58012294
86PAK10.57895853
87PRKAA20.56121510
88PAK40.55895750
89TSSK60.55761956
90PRKCI0.55618848
91CDK40.54464732
92CAMK2G0.53530079
93PLK10.51978039
94SCYL20.51740510
95VRK10.51478382
96MTOR0.51342279
97MAPKAPK50.50681296
98MAPK120.50323042
99RPS6KA10.50272612
100ATR0.50140409
101PRKD20.50124504
102CSNK1G30.49342669
103AURKA0.48753562
104IRAK20.46849920
105CDK11A0.46705468
106PDPK10.46630707
107MAP3K80.45886074
108RPS6KA40.44873735
109RPS6KA50.44852695
110STK40.44681908
111EPHA20.44653357
112MAP3K10.44170018
113PIK3CA0.44021235
114PTK20.42927287
115STK380.42633271
116LRRK20.42464509
117MAP3K70.42142963
118CDK150.42126872
119AURKB0.41613062
120MAP3K120.40213308
121MAP2K60.39859040
122DYRK30.39779574
123CDK140.39457700
124CDK180.38547762
125MUSK0.38530484
126PRKACG0.36869862
127ABL20.36844351
128MAP2K20.36544687
129PAK30.36215686
130CSK0.36150188
131TRPM70.35672852
132CDK60.35149642
133KSR20.35088972
134GSK3A0.34679120
135NEK20.34580849
136WNK30.34348193
137PTK60.33878672
138CHEK10.33674207
139MOS0.33468694
140FGFR40.32947392
141CSNK2A20.32367829
142CDK120.31690813
143FGR0.31120740
144CSNK1A1L0.30418867
145CSNK2A10.30156416
146PRKG20.29434691
147RAF10.28077619

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.87674697
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012104.53236804
3Propanoate metabolism_Homo sapiens_hsa006403.20755782
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.02280023
5Fatty acid degradation_Homo sapiens_hsa000712.93109986
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.84923299
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.80585102
8Carbon metabolism_Homo sapiens_hsa012002.74123003
9Fatty acid metabolism_Homo sapiens_hsa012122.54293382
10Parkinsons disease_Homo sapiens_hsa050122.33723180
11Biosynthesis of amino acids_Homo sapiens_hsa012302.32320828
12Pyruvate metabolism_Homo sapiens_hsa006202.31082732
13* Oxidative phosphorylation_Homo sapiens_hsa001902.23257511
14* Cardiac muscle contraction_Homo sapiens_hsa042602.01853026
15Arginine biosynthesis_Homo sapiens_hsa002201.88585790
16Butanoate metabolism_Homo sapiens_hsa006501.82361795
17Fatty acid biosynthesis_Homo sapiens_hsa000611.68490985
18Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.60760020
19Tryptophan metabolism_Homo sapiens_hsa003801.58293412
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.49901317
21* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.49265253
22Huntingtons disease_Homo sapiens_hsa050161.47821456
23Arginine and proline metabolism_Homo sapiens_hsa003301.45943784
24Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.44643906
25PPAR signaling pathway_Homo sapiens_hsa033201.42690892
26Alzheimers disease_Homo sapiens_hsa050101.41910377
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.38251490
28Primary bile acid biosynthesis_Homo sapiens_hsa001201.37164762
29DNA replication_Homo sapiens_hsa030301.35103474
30beta-Alanine metabolism_Homo sapiens_hsa004101.32638946
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.31465955
32Peroxisome_Homo sapiens_hsa041461.29095547
33Sulfur relay system_Homo sapiens_hsa041221.28944426
34RNA polymerase_Homo sapiens_hsa030201.28636635
35Mismatch repair_Homo sapiens_hsa034301.27086990
36Fatty acid elongation_Homo sapiens_hsa000621.26695974
37Pentose and glucuronate interconversions_Homo sapiens_hsa000401.22483588
38Fructose and mannose metabolism_Homo sapiens_hsa000511.22032306
39Nitrogen metabolism_Homo sapiens_hsa009101.20023616
40Folate biosynthesis_Homo sapiens_hsa007901.17947559
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.16204170
42Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.13386162
43Starch and sucrose metabolism_Homo sapiens_hsa005001.11140139
44Base excision repair_Homo sapiens_hsa034101.09553394
45Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.07818293
46Cyanoamino acid metabolism_Homo sapiens_hsa004601.06613102
47Proteasome_Homo sapiens_hsa030501.02951965
48Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.01909737
49Vitamin B6 metabolism_Homo sapiens_hsa007501.01338584
50Fat digestion and absorption_Homo sapiens_hsa049751.00330225
51Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.99831602
52Galactose metabolism_Homo sapiens_hsa000520.99396273
53Other glycan degradation_Homo sapiens_hsa005110.99256891
54Pentose phosphate pathway_Homo sapiens_hsa000300.96668136
55Selenocompound metabolism_Homo sapiens_hsa004500.94467673
56Purine metabolism_Homo sapiens_hsa002300.91619250
57Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.90243507
58Phenylalanine metabolism_Homo sapiens_hsa003600.89365267
59Glutathione metabolism_Homo sapiens_hsa004800.89236608
60N-Glycan biosynthesis_Homo sapiens_hsa005100.88373311
61Dilated cardiomyopathy_Homo sapiens_hsa054140.87164836
62Cell cycle_Homo sapiens_hsa041100.86214689
63Lysine degradation_Homo sapiens_hsa003100.86057728
64Ribosome_Homo sapiens_hsa030100.86057536
65One carbon pool by folate_Homo sapiens_hsa006700.84123683
66Drug metabolism - other enzymes_Homo sapiens_hsa009830.81620617
67Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.77105142
68Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.76894837
69Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.69147241
70Vibrio cholerae infection_Homo sapiens_hsa051100.65781978
71* Metabolic pathways_Homo sapiens_hsa011000.65369668
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.64191076
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62835397
74Bile secretion_Homo sapiens_hsa049760.61112086
75Tyrosine metabolism_Homo sapiens_hsa003500.57377705
76Glycerolipid metabolism_Homo sapiens_hsa005610.57216577
77Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56229331
78Systemic lupus erythematosus_Homo sapiens_hsa053220.54619644
79Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.53676753
80Glucagon signaling pathway_Homo sapiens_hsa049220.51886527
81AMPK signaling pathway_Homo sapiens_hsa041520.50481846
82Non-homologous end-joining_Homo sapiens_hsa034500.49917900
83Sulfur metabolism_Homo sapiens_hsa009200.49407868
84Insulin signaling pathway_Homo sapiens_hsa049100.46121882
85Central carbon metabolism in cancer_Homo sapiens_hsa052300.46043596
86Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45458936
87mRNA surveillance pathway_Homo sapiens_hsa030150.44881442
88Prion diseases_Homo sapiens_hsa050200.43079562
89Chemical carcinogenesis_Homo sapiens_hsa052040.42994270
90Fanconi anemia pathway_Homo sapiens_hsa034600.42960276
91Pyrimidine metabolism_Homo sapiens_hsa002400.42671706
92Nucleotide excision repair_Homo sapiens_hsa034200.42370712
93RNA transport_Homo sapiens_hsa030130.42342494
94Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.42210522
95Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.41560421
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.40760519
97Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.40035453
98Glycosaminoglycan degradation_Homo sapiens_hsa005310.40003279
99Epstein-Barr virus infection_Homo sapiens_hsa051690.39637273
100Caffeine metabolism_Homo sapiens_hsa002320.38915516
101Spliceosome_Homo sapiens_hsa030400.36828436
102Insulin resistance_Homo sapiens_hsa049310.36021350
103Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.35285540
104Viral myocarditis_Homo sapiens_hsa054160.33096388
105Alcoholism_Homo sapiens_hsa050340.32888965
106Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.32636988
107Thyroid cancer_Homo sapiens_hsa052160.32399786
108Viral carcinogenesis_Homo sapiens_hsa052030.31350980
109Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.31252686
110Shigellosis_Homo sapiens_hsa051310.29171770
111Histidine metabolism_Homo sapiens_hsa003400.27999641
112Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.26627545
113Longevity regulating pathway - mammal_Homo sapiens_hsa042110.25711565
114Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.25645657
115Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.23108960
116Chronic myeloid leukemia_Homo sapiens_hsa052200.22351080
117Acute myeloid leukemia_Homo sapiens_hsa052210.21954668
118HIF-1 signaling pathway_Homo sapiens_hsa040660.19887950
119Complement and coagulation cascades_Homo sapiens_hsa046100.19435726
120mTOR signaling pathway_Homo sapiens_hsa041500.18510039
121Non-small cell lung cancer_Homo sapiens_hsa052230.18393030
122Retinol metabolism_Homo sapiens_hsa008300.17952697
123Apoptosis_Homo sapiens_hsa042100.17774950
124Steroid biosynthesis_Homo sapiens_hsa001000.16571237
125Homologous recombination_Homo sapiens_hsa034400.16421065
126Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.15291708
127Circadian rhythm_Homo sapiens_hsa047100.15105179
128Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.14813675
129HTLV-I infection_Homo sapiens_hsa051660.13349009
130Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.13042079
131Tight junction_Homo sapiens_hsa045300.12435892
132Bladder cancer_Homo sapiens_hsa052190.12303013

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