CYCS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a small heme protein that functions as a central component of the electron transport chain in mitochondria. The encoded protein associates with the inner membrane of the mitochondrion where it accepts electrons from cytochrome b and transfers them to the cytochrome oxidase complex. This protein is also involved in initiation of apoptosis. Mutations in this gene are associated with autosomal dominant nonsyndromic thrombocytopenia. Numerous processed pseudogenes of this gene are found throughout the human genome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial electron transport, NADH to ubiquinone (GO:0006120)9.75460714
2* respiratory electron transport chain (GO:0022904)9.05433979
3* electron transport chain (GO:0022900)8.82939785
4oxidative phosphorylation (GO:0006119)5.91725351
5chaperone-mediated protein transport (GO:0072321)5.78626893
6ATP biosynthetic process (GO:0006754)5.60809220
7mitochondrial respiratory chain complex I assembly (GO:0032981)5.55919304
8NADH dehydrogenase complex assembly (GO:0010257)5.55919304
9mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.55919304
10protein complex biogenesis (GO:0070271)5.54963041
11tricarboxylic acid cycle (GO:0006099)5.26554712
12hydrogen ion transmembrane transport (GO:1902600)5.25699644
13purine ribonucleoside triphosphate biosynthetic process (GO:0009206)5.17369328
14inner mitochondrial membrane organization (GO:0007007)5.14397131
15purine nucleoside triphosphate biosynthetic process (GO:0009145)5.10101152
16mitochondrial respiratory chain complex assembly (GO:0033108)5.05208801
17establishment of protein localization to mitochondrial membrane (GO:0090151)4.95029498
18protein neddylation (GO:0045116)4.81561165
19proton transport (GO:0015992)4.68209510
20regulation of acyl-CoA biosynthetic process (GO:0050812)4.63973466
21hydrogen transport (GO:0006818)4.60522190
22ribonucleoside triphosphate biosynthetic process (GO:0009201)4.50570174
23ribosome assembly (GO:0042255)4.45698741
24aerobic respiration (GO:0009060)4.43187474
25regulation of cofactor metabolic process (GO:0051193)4.39085555
26regulation of coenzyme metabolic process (GO:0051196)4.39085555
27NADH metabolic process (GO:0006734)4.26537965
28negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.20214120
29regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.17451151
30establishment of integrated proviral latency (GO:0075713)4.15355247
31regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.04958185
32anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.95626827
33positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.92266296
34nucleoside triphosphate biosynthetic process (GO:0009142)3.92175166
35mitotic metaphase plate congression (GO:0007080)3.90589514
36negative regulation of ligase activity (GO:0051352)3.87279263
37negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.87279263
38energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.86512539
39ATP hydrolysis coupled proton transport (GO:0015991)3.86512539
40CENP-A containing nucleosome assembly (GO:0034080)3.85056426
41regulation of mitochondrial translation (GO:0070129)3.79978095
42chromatin remodeling at centromere (GO:0031055)3.76313734
43mitochondrial transport (GO:0006839)3.71342406
44IMP biosynthetic process (GO:0006188)3.70729582
45DNA replication checkpoint (GO:0000076)3.66838287
46GTP biosynthetic process (GO:0006183)3.65329710
47succinate metabolic process (GO:0006105)3.63747098
48quinone biosynthetic process (GO:1901663)3.63399002
49ubiquinone biosynthetic process (GO:0006744)3.63399002
50ribosomal large subunit biogenesis (GO:0042273)3.62245139
51purine nucleobase biosynthetic process (GO:0009113)3.57066292
52regulation of cellular respiration (GO:0043457)3.54703715
53regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.54111554
54protein targeting to mitochondrion (GO:0006626)3.51995451
55DNA strand elongation involved in DNA replication (GO:0006271)3.50002771
56negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.49549410
57positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.48385938
58protein localization to kinetochore (GO:0034501)3.44594122
59respiratory chain complex IV assembly (GO:0008535)3.44515148
60formation of translation preinitiation complex (GO:0001731)3.44282149
61establishment of protein localization to mitochondrion (GO:0072655)3.43341685
62protein localization to mitochondrion (GO:0070585)3.42941905
63cytochrome complex assembly (GO:0017004)3.42098576
64ubiquinone metabolic process (GO:0006743)3.41917514
65regulation of oxidative phosphorylation (GO:0002082)3.41454823
66purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.41274451
67purine nucleoside monophosphate biosynthetic process (GO:0009127)3.41274451
68* cellular respiration (GO:0045333)3.39723660
69IMP metabolic process (GO:0046040)3.39151055
70metaphase plate congression (GO:0051310)3.38606707
71establishment of viral latency (GO:0019043)3.36290185
72* generation of precursor metabolites and energy (GO:0006091)3.36086158
73DNA strand elongation (GO:0022616)3.35841171
74positive regulation of ligase activity (GO:0051351)3.33057098
75telomere maintenance via semi-conservative replication (GO:0032201)3.31390772
76positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.29408074
77cullin deneddylation (GO:0010388)3.29288011
78regulation of ubiquitin-protein transferase activity (GO:0051438)3.28578355
79rRNA modification (GO:0000154)3.27892002
80tRNA aminoacylation for protein translation (GO:0006418)3.27180497
81dopamine transport (GO:0015872)3.26861743
82nucleobase biosynthetic process (GO:0046112)3.26338945
83maturation of 5.8S rRNA (GO:0000460)3.26314516
84amino acid activation (GO:0043038)3.25999066
85tRNA aminoacylation (GO:0043039)3.25999066
86DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.25718384
87signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.25544623
88signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.25544623
89signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.25544623
90intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.24703055
91signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.24703055
92transcription from mitochondrial promoter (GO:0006390)3.24513902
93spliceosomal snRNP assembly (GO:0000387)3.21769430
94signal transduction involved in DNA integrity checkpoint (GO:0072401)3.20235076
95signal transduction involved in DNA damage checkpoint (GO:0072422)3.20235076
96regulation of sulfur metabolic process (GO:0042762)3.18983967
97mitotic sister chromatid segregation (GO:0000070)3.18073286
98histone exchange (GO:0043486)3.17962851
99regulation of ligase activity (GO:0051340)3.16467266
100DNA damage response, detection of DNA damage (GO:0042769)3.15270696
101signal transduction involved in cell cycle checkpoint (GO:0072395)3.15229640
102protein localization to chromosome, centromeric region (GO:0071459)3.13520512
103regulation of cell communication by electrical coupling (GO:0010649)3.13296367
104ribosome biogenesis (GO:0042254)3.11523446
105nucleobase-containing small molecule interconversion (GO:0015949)3.10368889
106pseudouridine synthesis (GO:0001522)3.08701381
107nuclear pore complex assembly (GO:0051292)3.06869452
108ribonucleoprotein complex biogenesis (GO:0022613)3.06482901
109rRNA processing (GO:0006364)3.06463589
110heart contraction (GO:0060047)3.05508630
111heart process (GO:0003015)3.05508630
112spindle checkpoint (GO:0031577)2.94990468
113protein deneddylation (GO:0000338)2.94860875
114purine nucleoside biosynthetic process (GO:0042451)2.94638369
115purine ribonucleoside biosynthetic process (GO:0046129)2.94638369
116protein-cofactor linkage (GO:0018065)2.94026195
117nuclear pore organization (GO:0006999)2.93984724
118UTP biosynthetic process (GO:0006228)2.93962949
119substantia nigra development (GO:0021762)2.93782134
120cellular component biogenesis (GO:0044085)2.93274812
121rRNA metabolic process (GO:0016072)2.92954472
122mitochondrial RNA metabolic process (GO:0000959)2.91398039
123G1/S transition of mitotic cell cycle (GO:0000082)2.91194038
124cell cycle G1/S phase transition (GO:0044843)2.91194038
125rRNA methylation (GO:0031167)2.91060356
126pteridine-containing compound biosynthetic process (GO:0042559)2.90042894
127sister chromatid segregation (GO:0000819)2.89056810
128DNA replication-independent nucleosome organization (GO:0034724)2.88826872
129DNA replication-independent nucleosome assembly (GO:0006336)2.88826872
130mitotic spindle checkpoint (GO:0071174)2.88795841
131translation (GO:0006412)2.88268095
132regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.88014936
1337-methylguanosine mRNA capping (GO:0006370)2.87743749
134folic acid-containing compound biosynthetic process (GO:0009396)2.87559333
135positive regulation of mitochondrial fission (GO:0090141)2.86919841
136proteasome assembly (GO:0043248)2.81675567
137regulation of relaxation of muscle (GO:1901077)2.78864061
138intracellular protein transmembrane import (GO:0044743)2.75126077
139response to epinephrine (GO:0071871)2.73605837
140regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.72219924
141mitochondrion morphogenesis (GO:0070584)2.67677355
142guanosine-containing compound biosynthetic process (GO:1901070)2.67140443
143actin-myosin filament sliding (GO:0033275)2.66174980
144muscle filament sliding (GO:0030049)2.66174980
145oxaloacetate metabolic process (GO:0006107)2.65422917
146ribonucleoside monophosphate biosynthetic process (GO:0009156)2.64987139
147regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.63808570
148UTP metabolic process (GO:0046051)2.61319217
149regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.59459488
150calcium-mediated signaling using intracellular calcium source (GO:0035584)2.58569581
151quinone metabolic process (GO:1901661)2.56046516
152negative regulation of synaptic transmission, GABAergic (GO:0032229)2.55971094
153sarcomere organization (GO:0045214)2.55677586
154negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.55384065
155negative regulation of calcium ion transmembrane transport (GO:1903170)2.55384065
156L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.54903303
157regulation of cellular amino acid metabolic process (GO:0006521)2.54673699
158nucleoside diphosphate phosphorylation (GO:0006165)2.54303825
159regulation of protein kinase A signaling (GO:0010738)2.51082756
160ribosomal small subunit biogenesis (GO:0042274)2.48840538
161regulation of sequestering of triglyceride (GO:0010889)2.47034559
162sarcoplasmic reticulum calcium ion transport (GO:0070296)2.44651973
163ribonucleoside biosynthetic process (GO:0042455)2.44263910
164negative regulation of protein localization to cell surface (GO:2000009)2.42129289
165neuron cell-cell adhesion (GO:0007158)2.41841314
166nucleoside monophosphate biosynthetic process (GO:0009124)2.41602295
167termination of RNA polymerase III transcription (GO:0006386)2.40389158
168transcription elongation from RNA polymerase III promoter (GO:0006385)2.40389158
169mitochondrial ATP synthesis coupled proton transport (GO:0042776)10.8293432
170ATP synthesis coupled proton transport (GO:0015986)10.2027813
171energy coupled proton transport, down electrochemical gradient (GO:0015985)10.2027813

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.76352453
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.09548587
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.61878598
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.59260151
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.46947295
6ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.33498801
7EZH2_22144423_ChIP-Seq_EOC_Human3.16807878
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.08345070
9FOXM1_23109430_ChIP-Seq_U2OS_Human3.06797246
10* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.93782599
11GBX2_23144817_ChIP-Seq_PC3_Human2.83438308
12VDR_22108803_ChIP-Seq_LS180_Human2.82030590
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.81919422
14TAF15_26573619_Chip-Seq_HEK293_Human2.77434809
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.76839842
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.72702558
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.68332351
18AR_21909140_ChIP-Seq_LNCAP_Human2.58452283
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.47420939
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.47248487
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.43652351
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.39972417
23* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.33150936
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.13414380
25* XRN2_22483619_ChIP-Seq_HELA_Human2.09634576
26* PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.06188485
27* ETS1_20019798_ChIP-Seq_JURKAT_Human2.05600899
28FOXP3_21729870_ChIP-Seq_TREG_Human2.05197936
29PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.04058405
30FUS_26573619_Chip-Seq_HEK293_Human2.03289393
31NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.01785576
32ZFP57_27257070_Chip-Seq_ESCs_Mouse2.01185280
33POU3F2_20337985_ChIP-ChIP_501MEL_Human2.00293995
34KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.99763276
35YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.99739696
36MYCN_18555785_ChIP-Seq_MESCs_Mouse1.93821972
37PADI4_21655091_ChIP-ChIP_MCF-7_Human1.89917231
38GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.88913298
39HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.87519486
40* GABP_19822575_ChIP-Seq_HepG2_Human1.84885536
41SRF_21415370_ChIP-Seq_HL-1_Mouse1.77550524
42POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.77349488
43* E2F1_21310950_ChIP-Seq_MCF-7_Human1.76610755
44BMI1_23680149_ChIP-Seq_NPCS_Mouse1.73883405
45CTBP1_25329375_ChIP-Seq_LNCAP_Human1.71900747
46SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.70426990
47MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.67854915
48CTBP2_25329375_ChIP-Seq_LNCAP_Human1.67078480
49SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.65340687
50ELF1_17652178_ChIP-ChIP_JURKAT_Human1.64218047
51P300_19829295_ChIP-Seq_ESCs_Human1.63687668
52FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.62143731
53JARID2_20064375_ChIP-Seq_MESCs_Mouse1.61793257
54ER_23166858_ChIP-Seq_MCF-7_Human1.61166256
55HOXB4_20404135_ChIP-ChIP_EML_Mouse1.60698080
56ZFX_18555785_ChIP-Seq_MESCs_Mouse1.58972864
57BP1_19119308_ChIP-ChIP_Hs578T_Human1.56878023
58MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.56640244
59TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52380611
60EZH2_27304074_Chip-Seq_ESCs_Mouse1.48896810
61* DCP1A_22483619_ChIP-Seq_HELA_Human1.46938602
62* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.43849810
63SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42912899
64POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.42741434
65THAP11_20581084_ChIP-Seq_MESCs_Mouse1.40979278
66FLI1_27457419_Chip-Seq_LIVER_Mouse1.39670086
67UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.39495129
68TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39413713
69ELK1_19687146_ChIP-ChIP_HELA_Human1.38901938
70CBX2_27304074_Chip-Seq_ESCs_Mouse1.38498980
71PCGF2_27294783_Chip-Seq_ESCs_Mouse1.37743362
72MYC_18555785_ChIP-Seq_MESCs_Mouse1.36584733
73SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.36296377
74YY1_21170310_ChIP-Seq_MESCs_Mouse1.36244750
75SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.34758285
76NANOG_18555785_ChIP-Seq_MESCs_Mouse1.33545107
77MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.32586319
78PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.28724242
79HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.26979687
80ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.26414923
81EED_16625203_ChIP-ChIP_MESCs_Mouse1.24740294
82MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.24549362
83ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.23133553
84OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21188675
85JARID2_20075857_ChIP-Seq_MESCs_Mouse1.19897399
86EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.18680947
87* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.18294251
88CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.18242518
89JUN_21703547_ChIP-Seq_K562_Human1.16003877
90SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.15545170
91KDM5A_27292631_Chip-Seq_BREAST_Human1.14736318
92EP300_21415370_ChIP-Seq_HL-1_Mouse1.13031813
93ELK1_22589737_ChIP-Seq_MCF10A_Human1.12230891
94EWS_26573619_Chip-Seq_HEK293_Human1.12048247
95RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.12033304
96* VDR_23849224_ChIP-Seq_CD4+_Human1.11632888
97PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.11044818
98CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.10039230
99SMAD4_21799915_ChIP-Seq_A2780_Human1.08170741
100RNF2_18974828_ChIP-Seq_MESCs_Mouse1.08014441
101EZH2_18974828_ChIP-Seq_MESCs_Mouse1.08014441
102E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.06618079
103REST_21632747_ChIP-Seq_MESCs_Mouse1.06298762
104* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.06060695
105* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.05509578
106* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05255261
107* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.04801565
108SOX17_20123909_ChIP-Seq_XEN_Mouse1.04677868
109PIAS1_25552417_ChIP-Seq_VCAP_Human1.04575026
110CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.04541375
111SMAD3_21741376_ChIP-Seq_EPCs_Human1.04084316
112NANOG_16153702_ChIP-ChIP_HESCs_Human1.03486571
113E2F1_18555785_ChIP-Seq_MESCs_Mouse1.02491980
114SALL1_21062744_ChIP-ChIP_HESCs_Human1.01874398
115MTF2_20144788_ChIP-Seq_MESCs_Mouse1.00349380
116NR3C1_23031785_ChIP-Seq_PC12_Mouse0.99922600
117HTT_18923047_ChIP-ChIP_STHdh_Human0.99539196
118ZNF274_21170338_ChIP-Seq_K562_Hela0.99067237
119MYC_18940864_ChIP-ChIP_HL60_Human0.98460347
120NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.97866612
121SOX2_19829295_ChIP-Seq_ESCs_Human0.97677924
122NANOG_19829295_ChIP-Seq_ESCs_Human0.97677924
123IRF1_19129219_ChIP-ChIP_H3396_Human0.97446962
124SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.95850661
125EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95433595
126TFEB_21752829_ChIP-Seq_HELA_Human0.94964517
127* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.93342963
128P53_22387025_ChIP-Seq_ESCs_Mouse0.93313974
129DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.92379872
130ERG_20887958_ChIP-Seq_HPC-7_Mouse0.92303757
131NANOG_18555785_Chip-Seq_ESCs_Mouse0.91456393
132* TTF2_22483619_ChIP-Seq_HELA_Human0.91083336
133CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.91013512
134PRDM14_20953172_ChIP-Seq_ESCs_Human0.90530063
135SUZ12_18555785_Chip-Seq_ESCs_Mouse0.89934501
136CDX2_19796622_ChIP-Seq_MESCs_Mouse0.89475796
137CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.89184448
138REST_18959480_ChIP-ChIP_MESCs_Mouse0.88635249
139SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.88550307
140STAT3_18555785_Chip-Seq_ESCs_Mouse0.88170335
141STAT3_1855785_ChIP-Seq_MESCs_Mouse0.87955609
142CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.87018168
143ZNF263_19887448_ChIP-Seq_K562_Human0.86296325
144TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.86262547
145KLF4_18555785_ChIP-Seq_MESCs_Mouse0.85625259
146SOX2_16153702_ChIP-ChIP_HESCs_Human0.85139085
147NOTCH1_21737748_ChIP-Seq_TLL_Human0.84253630
148RBPJ_22232070_ChIP-Seq_NCS_Mouse0.80698618
149TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.80054306
150CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.79481112
151SOX2_18555785_ChIP-Seq_MESCs_Mouse0.79015765
152SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.78239949
153ELF5_23300383_ChIP-Seq_T47D_Human0.76947996
154SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.76233251
155POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.73565660
156SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.71065509
157TBX5_21415370_ChIP-Seq_HL-1_Mouse0.71042109
158NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.70747445
159CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.70613343
160POU5F1_16153702_ChIP-ChIP_HESCs_Human0.69528142

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.34780489
2MP0003646_muscle_fatigue4.26659896
3MP0002837_dystrophic_cardiac_calcinosis4.25285489
4MP0004957_abnormal_blastocyst_morpholog4.18520398
5MP0003880_abnormal_central_pattern4.11590589
6MP0010094_abnormal_chromosome_stability3.91356168
7MP0008058_abnormal_DNA_repair3.57386447
8MP0001529_abnormal_vocalization3.40713269
9MP0003111_abnormal_nucleus_morphology3.40038973
10MP0003077_abnormal_cell_cycle3.06257046
11MP0008932_abnormal_embryonic_tissue2.95077906
12MP0009379_abnormal_foot_pigmentation2.92557596
13* MP0006036_abnormal_mitochondrial_physio2.82890719
14MP0004215_abnormal_myocardial_fiber2.81748644
15MP0000751_myopathy2.73204189
16MP0008057_abnormal_DNA_replication2.69525850
17MP0000749_muscle_degeneration2.61405716
18MP0004084_abnormal_cardiac_muscle2.55684348
19MP0004036_abnormal_muscle_relaxation2.49633554
20MP0002736_abnormal_nociception_after2.46856848
21MP0006035_abnormal_mitochondrial_morpho2.42111666
22MP0003718_maternal_effect2.40810107
23MP0003941_abnormal_skin_development2.39661883
24MP0006276_abnormal_autonomic_nervous2.35754513
25MP0008007_abnormal_cellular_replicative2.35104565
26MP0001968_abnormal_touch/_nociception2.28414391
27MP0001905_abnormal_dopamine_level2.27767803
28MP0005330_cardiomyopathy2.24306922
29MP0009745_abnormal_behavioral_response2.07248494
30MP0004484_altered_response_of2.07190915
31MP0009046_muscle_twitch2.04864353
32MP0004142_abnormal_muscle_tone1.88977181
33MP0002972_abnormal_cardiac_muscle1.88818075
34MP0001440_abnormal_grooming_behavior1.88603726
35MP0002064_seizures1.86262498
36MP0003786_premature_aging1.85767474
37MP0002272_abnormal_nervous_system1.84247276
38MP0004043_abnormal_pH_regulation1.81335967
39MP0002735_abnormal_chemical_nociception1.81055523
40MP0001730_embryonic_growth_arrest1.75402682
41MP0003635_abnormal_synaptic_transmissio1.72823912
42MP0005620_abnormal_muscle_contractility1.72808042
43MP0003137_abnormal_impulse_conducting1.71665085
44MP0008775_abnormal_heart_ventricle1.71539837
45MP0005386_behavior/neurological_phenoty1.62892688
46MP0004924_abnormal_behavior1.62892688
47MP0002332_abnormal_exercise_endurance1.62028223
48MP0002572_abnormal_emotion/affect_behav1.61016528
49MP0004145_abnormal_muscle_electrophysio1.58681945
50MP0002102_abnormal_ear_morphology1.57029234
51MP0000350_abnormal_cell_proliferation1.51847688
52MP0002822_catalepsy1.51457443
53MP0002734_abnormal_mechanical_nocicepti1.49703871
54MP0002063_abnormal_learning/memory/cond1.46413370
55MP0001486_abnormal_startle_reflex1.43854478
56MP0005171_absent_coat_pigmentation1.43497226
57MP0004085_abnormal_heartbeat1.41773333
58MP0004859_abnormal_synaptic_plasticity1.41686419
59MP0005535_abnormal_body_temperature1.41289892
60MP0006138_congestive_heart_failure1.40798253
61MP0001501_abnormal_sleep_pattern1.40638790
62MP0002067_abnormal_sensory_capabilities1.40135678
63MP0005408_hypopigmentation1.38756399
64MP0004270_analgesia1.37773703
65MP0003890_abnormal_embryonic-extraembry1.36165237
66MP0002106_abnormal_muscle_physiology1.34775698
67MP0002638_abnormal_pupillary_reflex1.34211307
68* MP0001697_abnormal_embryo_size1.31931109
69MP0006072_abnormal_retinal_apoptosis1.31086621
70MP0001970_abnormal_pain_threshold1.30962897
71MP0003221_abnormal_cardiomyocyte_apopto1.30396712
72MP0002876_abnormal_thyroid_physiology1.29921299
73MP0001188_hyperpigmentation1.27529848
74MP0003567_abnormal_fetal_cardiomyocyte1.27014677
75MP0001544_abnormal_cardiovascular_syste1.26331550
76MP0005385_cardiovascular_system_phenoty1.26331550
77MP0004130_abnormal_muscle_cell1.24527256
78MP0003195_calcinosis1.24440149
79MP0004233_abnormal_muscle_weight1.22398391
80MP0000358_abnormal_cell_content/1.22025149
81* MP0001672_abnormal_embryogenesis/_devel1.18270652
82* MP0005380_embryogenesis_phenotype1.18270652
83MP0004087_abnormal_muscle_fiber1.18072054
84MP0010352_gastrointestinal_tract_polyps1.17870579
85MP0010234_abnormal_vibrissa_follicle1.17684004
86MP0009697_abnormal_copulation1.16863950
87MP0001727_abnormal_embryo_implantation1.16076665
88MP0001485_abnormal_pinna_reflex1.14694364
89MP0004147_increased_porphyrin_level1.13247196
90* MP0002080_prenatal_lethality1.13056550
91MP0002163_abnormal_gland_morphology1.13006285
92MP0003950_abnormal_plasma_membrane1.12277804
93MP0003136_yellow_coat_color1.11053328
94MP0002090_abnormal_vision1.10967449
95MP0002938_white_spotting1.10142861
96MP0005369_muscle_phenotype1.09185268
97MP0000372_irregular_coat_pigmentation1.07509118
98MP0002733_abnormal_thermal_nociception1.06564886
99MP0003186_abnormal_redox_activity1.04782874
100MP0009672_abnormal_birth_weight1.02080661
101MP0003123_paternal_imprinting1.01511038
102MP0005187_abnormal_penis_morphology1.00201448
103MP0002085_abnormal_embryonic_tissue0.99256849
104MP0000230_abnormal_systemic_arterial0.99002696
105MP0002084_abnormal_developmental_patter0.98726830
106MP0010386_abnormal_urinary_bladder0.98178585
107MP0000747_muscle_weakness0.97341590
108MP0003937_abnormal_limbs/digits/tail_de0.96768000
109* MP0003984_embryonic_growth_retardation0.95581427
110MP0001293_anophthalmia0.95381857
111MP0002160_abnormal_reproductive_system0.94308217
112MP0000750_abnormal_muscle_regeneration0.93562843
113MP0001984_abnormal_olfaction0.93369798
114MP0000759_abnormal_skeletal_muscle0.92637094
115* MP0002088_abnormal_embryonic_growth/wei0.91801293
116MP0004742_abnormal_vestibular_system0.91170502
117MP0002877_abnormal_melanocyte_morpholog0.90874123
118MP0003806_abnormal_nucleotide_metabolis0.90713922
119MP0000013_abnormal_adipose_tissue0.89140015
120MP0000647_abnormal_sebaceous_gland0.88965319
121MP0003122_maternal_imprinting0.88507436
122MP0005266_abnormal_metabolism0.87805091
123MP0005423_abnormal_somatic_nervous0.86386266
124MP0002127_abnormal_cardiovascular_syste0.83731232
125MP0002210_abnormal_sex_determination0.83479593
126MP0005409_darkened_coat_color0.83415436
127* MP0000313_abnormal_cell_death0.83271626
128MP0008877_abnormal_DNA_methylation0.82913617
129* MP0002066_abnormal_motor_capabilities/c0.82123671
130MP0005165_increased_susceptibility_to0.82002908
131MP0002184_abnormal_innervation0.81125242
132MP0001986_abnormal_taste_sensitivity0.80310251
133MP0005332_abnormal_amino_acid0.80247022
134MP0001664_abnormal_digestion0.78724299
135MP0001929_abnormal_gametogenesis0.78205048
136MP0008872_abnormal_physiological_respon0.77524695
137MP0002796_impaired_skin_barrier0.76179460
138MP0005636_abnormal_mineral_homeostasis0.76166743
139MP0005379_endocrine/exocrine_gland_phen0.75588262
140MP0002229_neurodegeneration0.75164830
141MP0002269_muscular_atrophy0.74493897
142MP0001661_extended_life_span0.74363978
143MP0005253_abnormal_eye_physiology0.73842339
144MP0001963_abnormal_hearing_physiology0.73166624
145MP0004197_abnormal_fetal_growth/weight/0.72971595
146MP0000920_abnormal_myelination0.72529138
147MP0000778_abnormal_nervous_system0.72443150
148MP0008004_abnormal_stomach_pH0.71589328
149MP0002557_abnormal_social/conspecific_i0.71158442
150MP0001764_abnormal_homeostasis0.70627385
151MP0003315_abnormal_perineum_morphology0.66779770
152MP0005501_abnormal_skin_physiology0.66572283
153* MP0002086_abnormal_extraembryonic_tissu0.63016305
154MP0001145_abnormal_male_reproductive0.62978851
155MP0010307_abnormal_tumor_latency0.62769943
156MP0000579_abnormal_nail_morphology0.61719780
157MP0003119_abnormal_digestive_system0.61360569
158MP0002234_abnormal_pharynx_morphology0.59719254
159MP0001881_abnormal_mammary_gland0.59547704

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)8.09905623
2Abnormal mitochondria in muscle tissue (HP:0008316)7.53080130
3Progressive macrocephaly (HP:0004481)6.93606485
4Mitochondrial inheritance (HP:0001427)6.76192813
5Acute encephalopathy (HP:0006846)6.74626709
6Increased CSF lactate (HP:0002490)5.96590681
7Hepatocellular necrosis (HP:0001404)5.77012946
8Hepatic necrosis (HP:0002605)5.46776074
9Increased serum pyruvate (HP:0003542)5.19589969
10Abnormality of glycolysis (HP:0004366)5.19589969
11Cerebral edema (HP:0002181)5.07062679
12Increased hepatocellular lipid droplets (HP:0006565)4.85338177
13Lipid accumulation in hepatocytes (HP:0006561)4.53231682
14Exercise intolerance (HP:0003546)4.35262740
15Respiratory failure (HP:0002878)4.33476653
16Lactic acidosis (HP:0003128)4.21398996
17Optic disc pallor (HP:0000543)4.17095589
18Increased intramyocellular lipid droplets (HP:0012240)4.15583665
19Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.11773319
20Renal Fanconi syndrome (HP:0001994)3.96284039
21Leukodystrophy (HP:0002415)3.95188790
22Increased muscle lipid content (HP:0009058)3.75887856
23Decreased activity of mitochondrial respiratory chain (HP:0008972)3.72445530
24Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.72445530
25Increased serum lactate (HP:0002151)3.69731822
26Neuroendocrine neoplasm (HP:0100634)3.60584596
27Pheochromocytoma (HP:0002666)3.58844470
28Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.57378674
293-Methylglutaconic aciduria (HP:0003535)3.04587631
30Exertional dyspnea (HP:0002875)3.02455665
31Sudden death (HP:0001699)3.00952553
32Muscle hypertrophy of the lower extremities (HP:0008968)3.00646267
33Calf muscle hypertrophy (HP:0008981)2.99427243
34X-linked dominant inheritance (HP:0001423)2.96009784
35Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.95841733
36Abnormality of alanine metabolism (HP:0010916)2.95841733
37Hyperalaninemia (HP:0003348)2.95841733
38Respiratory difficulties (HP:0002880)2.91374808
39Conjunctival hamartoma (HP:0100780)2.84382325
40Focal motor seizures (HP:0011153)2.74801372
41Palpitations (HP:0001962)2.67393956
42Birth length less than 3rd percentile (HP:0003561)2.67070760
43Abnormality of the anterior horn cell (HP:0006802)2.64939025
44Degeneration of anterior horn cells (HP:0002398)2.64939025
45CNS demyelination (HP:0007305)2.64031461
46Lethargy (HP:0001254)2.62943164
47Glycosuria (HP:0003076)2.62496215
48Abnormality of urine glucose concentration (HP:0011016)2.62496215
49Abnormality of renal resorption (HP:0011038)2.60156979
50Abnormality of methionine metabolism (HP:0010901)2.54595279
51Cerebral hypomyelination (HP:0006808)2.50596696
52Type I transferrin isoform profile (HP:0003642)2.42839586
53Multiple enchondromatosis (HP:0005701)2.39251779
54Nemaline bodies (HP:0003798)2.36492707
55Emotional lability (HP:0000712)2.34238915
56Chromosomal breakage induced by crosslinking agents (HP:0003221)2.34087725
57Macrocytic anemia (HP:0001972)2.31064777
58Methylmalonic aciduria (HP:0012120)2.29240902
59Chromsome breakage (HP:0040012)2.28437725
60Ragged-red muscle fibers (HP:0003200)2.27731959
61Abnormality of serum amino acid levels (HP:0003112)2.27387510
62Hyperventilation (HP:0002883)2.24855441
63Megaloblastic anemia (HP:0001889)2.24782406
64Reduced antithrombin III activity (HP:0001976)2.24535958
65Hyperphosphaturia (HP:0003109)2.23630300
66Abnormality of dicarboxylic acid metabolism (HP:0010995)2.21444279
67Dicarboxylic aciduria (HP:0003215)2.21444279
68Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.20782546
69Muscle fiber inclusion bodies (HP:0100299)2.19684123
70Methylmalonic acidemia (HP:0002912)2.18217439
71Progressive external ophthalmoplegia (HP:0000590)2.17422021
72Amniotic constriction ring (HP:0009775)2.16970517
73Abnormality of placental membranes (HP:0011409)2.16970517
74Exercise-induced muscle cramps (HP:0003710)2.16463196
75Abnormality of the calf musculature (HP:0001430)2.16462064
76Exercise-induced myalgia (HP:0003738)2.16117469
77Abnormality of the labia minora (HP:0012880)2.12583284
78Cortical dysplasia (HP:0002539)2.09041479
79Abnormal protein glycosylation (HP:0012346)2.08871072
80Abnormal glycosylation (HP:0012345)2.08871072
81Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.08871072
82Abnormal protein N-linked glycosylation (HP:0012347)2.08871072
83Vomiting (HP:0002013)2.08190768
84Myoglobinuria (HP:0002913)2.06388184
85Gliosis (HP:0002171)2.05888537
86Myokymia (HP:0002411)2.04496727
87Progressive muscle weakness (HP:0003323)2.01963017
88Microvesicular hepatic steatosis (HP:0001414)2.01962992
89Abnormality of the preputium (HP:0100587)2.01033659
90Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.97678951
91Hypoglycemic coma (HP:0001325)1.97572492
92Rhabdomyolysis (HP:0003201)1.97215147
93Abnormality of aspartate family amino acid metabolism (HP:0010899)1.95557919
94Cerebral hemorrhage (HP:0001342)1.95082363
95Atrial fibrillation (HP:0005110)1.94952471
96Oral leukoplakia (HP:0002745)1.94827340
97Neoplasm of head and neck (HP:0012288)1.93581933
98Esophageal neoplasm (HP:0100751)1.93581933
99Meckel diverticulum (HP:0002245)1.92463330
100Abnormality of chromosome stability (HP:0003220)1.91197817
101Generalized aminoaciduria (HP:0002909)1.88414747
102Cholecystitis (HP:0001082)1.88198583
103Abnormal gallbladder physiology (HP:0012438)1.88198583
104Ventricular tachycardia (HP:0004756)1.88028443
105Supraventricular tachycardia (HP:0004755)1.87766843
106Abnormal urine phosphate concentration (HP:0012599)1.87492715
107Atonic seizures (HP:0010819)1.85585624
108Syncope (HP:0001279)1.85481909
109Primary atrial arrhythmia (HP:0001692)1.85470864
110Postnatal microcephaly (HP:0005484)1.85147620
111Abnormal lung lobation (HP:0002101)1.84602243
112Blindness (HP:0000618)1.81952503
113Gout (HP:0001997)1.79993707
114Supraventricular arrhythmia (HP:0005115)1.79705540
115Neoplasm of the peripheral nervous system (HP:0100007)1.79548730
116Abnormality of the ileum (HP:0001549)1.78303990
117Lipoatrophy (HP:0100578)1.78110528
118Aplasia/Hypoplasia of the uvula (HP:0010293)1.77252692
119Renal tubular dysfunction (HP:0000124)1.76326775
120Nausea (HP:0002018)1.75778534
121Abnormal pupillary function (HP:0007686)1.75046474
122Abnormality of cells of the erythroid lineage (HP:0012130)1.74245017
123Sparse eyelashes (HP:0000653)1.73864627
124Reticulocytopenia (HP:0001896)1.73380856
125Proximal tubulopathy (HP:0000114)1.72829988
126Abnormal number of erythroid precursors (HP:0012131)1.72707599
127Hypoplastic left heart (HP:0004383)1.72237635
128Progressive inability to walk (HP:0002505)1.71837951
129Abnormality of the vocal cords (HP:0008777)1.70972226
130CNS hypomyelination (HP:0003429)1.69552866
131Neoplasm of the adrenal gland (HP:0100631)1.69546758
132Aplastic anemia (HP:0001915)1.69090844
133Myotonia (HP:0002486)1.67093937
134Sensory axonal neuropathy (HP:0003390)1.66306186
135Parakeratosis (HP:0001036)1.64605491
136Abnormality of fatty-acid metabolism (HP:0004359)1.64521452
137Prolonged QT interval (HP:0001657)1.64521004
138Epileptic encephalopathy (HP:0200134)1.62764343
139Metabolic acidosis (HP:0001942)1.62171252
140Duodenal stenosis (HP:0100867)1.60548389
141Small intestinal stenosis (HP:0012848)1.60548389
142Medial flaring of the eyebrow (HP:0010747)1.60489432
143Left ventricular hypertrophy (HP:0001712)1.60152121
144EMG: myopathic abnormalities (HP:0003458)1.60136830
145Neoplasm of the colon (HP:0100273)1.57767039
146Abnormality of homocysteine metabolism (HP:0010919)1.56197946
147Homocystinuria (HP:0002156)1.56197946
148Colon cancer (HP:0003003)1.55946124
149Congenital, generalized hypertrichosis (HP:0004540)1.54268891

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME13.62901293
2NEK13.58609988
3NME23.36390240
4CASK3.33598554
5MAP3K123.12622328
6MYLK2.88842328
7OBSCN2.79692782
8TTK2.68267656
9CDC72.59009699
10STK392.39089731
11EIF2AK12.26885001
12PDK42.14409179
13PDK32.14409179
14PLK42.10706154
15MAP2K72.08318296
16MST42.07816956
17GRK72.06641801
18TRIM282.06468738
19OXSR12.04034185
20VRK21.98872767
21STK161.94121916
22PLK21.92590427
23PBK1.92418992
24WNK41.82741629
25GRK51.80025789
26ARAF1.79145122
27MUSK1.78122497
28BRSK21.71876920
29EPHA41.69825129
30BCKDK1.54362870
31LIMK11.50679085
32MAP3K41.46905562
33RIPK41.46150053
34PLK11.44850827
35BCR1.40758259
36TLK11.39658657
37ERBB31.36126043
38STK241.35099522
39BMPR21.33583417
40PDK21.33107233
41PTK2B1.31549840
42SCYL21.27908297
43PNCK1.25378030
44EIF2AK31.24346044
45NTRK31.21151281
46CAMK2A1.18582020
47BRSK11.18137359
48ADRBK21.17683561
49BMPR1B1.17083748
50CDK191.14139621
51CAMK2D1.13065198
52STK38L1.09205443
53MINK11.08529247
54VRK11.07804153
55CAMK2B1.07564330
56MAP2K41.07381109
57PIK3CA1.05647752
58AURKB1.05113356
59TNIK1.01767531
60PHKG20.95757909
61PHKG10.95757909
62ADRBK10.95693270
63BUB10.94187011
64CHEK20.91427005
65LMTK20.89398631
66FGR0.87648583
67CCNB10.82238427
68TAF10.79048840
69CSNK1G10.78971528
70PRKCE0.76879280
71MAPK130.76483260
72ATR0.76022839
73ALK0.75834328
74CAMK2G0.75385577
75DAPK30.75357941
76PAK40.74667903
77PINK10.74257478
78ERBB40.71483981
79ABL20.70528008
80PKN10.70427693
81CSNK1A1L0.69551301
82CSNK1G20.69045905
83BRAF0.68897185
84CHEK10.67925796
85LATS20.65073573
86CDK80.64378098
87ROCK20.62815118
88TSSK60.61832967
89PRKACA0.61564158
90MAPKAPK50.61378184
91STK40.59068252
92STK30.57251830
93AURKA0.57060763
94NEK20.56949588
95CSNK1E0.56936425
96PRKCG0.56122964
97NUAK10.55269550
98UHMK10.54812035
99WNK30.54410453
100ILK0.53560705
101FES0.51679945
102DAPK10.51498529
103ATM0.50643883
104ZAK0.50538639
105AKT20.50440766
106DYRK20.49606397
107SRPK10.49547097
108MAP4K20.48101191
109EIF2AK20.44890725
110DYRK30.44544189
111MARK10.44527577
112MET0.42702100
113GRK60.42138567
114MAP3K80.42064231
115CDK140.41710759
116PIM20.41279611
117TTN0.40088871
118SIK30.39858654
119CDK10.39653127
120CDK50.39533422
121MAPK120.39443168
122PLK30.39121254
123CDK70.38669927
124MST1R0.38570840
125MAP3K110.38077514
126ACVR1B0.37912137
127RPS6KA40.36728824
128MKNK20.34427109
129PRKCI0.34122958
130CSNK1G30.33921359
131CDK180.33678752
132PRKCQ0.33267410
133CLK10.33043806
134RPS6KB20.30863541
135PASK0.30861362
136FGFR10.29784652
137CSNK2A10.29027722
138WEE10.28641372
139CDK150.27575455
140PRKACB0.27194821
141PRKG10.27120997
142CSNK2A20.26225684
143MKNK10.26210542
144MAP3K90.25879776

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001906.78590358
2Parkinsons disease_Homo sapiens_hsa050125.80387107
3Alzheimers disease_Homo sapiens_hsa050104.44073237
4Huntingtons disease_Homo sapiens_hsa050164.04841973
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.82663046
6* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.59861318
7Cardiac muscle contraction_Homo sapiens_hsa042603.49587214
8Mismatch repair_Homo sapiens_hsa034302.96759278
9DNA replication_Homo sapiens_hsa030302.93497790
10Proteasome_Homo sapiens_hsa030502.58366671
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.49370440
12Ribosome_Homo sapiens_hsa030102.45797082
13Spliceosome_Homo sapiens_hsa030402.09111941
14Propanoate metabolism_Homo sapiens_hsa006402.08003512
15RNA transport_Homo sapiens_hsa030132.06178129
16Collecting duct acid secretion_Homo sapiens_hsa049662.04163243
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.92764334
18One carbon pool by folate_Homo sapiens_hsa006701.87426352
19Pyruvate metabolism_Homo sapiens_hsa006201.86896017
20Fatty acid elongation_Homo sapiens_hsa000621.81188854
21Non-homologous end-joining_Homo sapiens_hsa034501.71835900
22Protein export_Homo sapiens_hsa030601.65089723
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.64832947
24Cell cycle_Homo sapiens_hsa041101.55472317
25Base excision repair_Homo sapiens_hsa034101.50068067
26Carbon metabolism_Homo sapiens_hsa012001.44757521
27Nicotine addiction_Homo sapiens_hsa050331.42624258
28RNA polymerase_Homo sapiens_hsa030201.40029056
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.35034348
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.33922132
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.27765634
32Fanconi anemia pathway_Homo sapiens_hsa034601.27024783
33Folate biosynthesis_Homo sapiens_hsa007901.25832223
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.19460416
35Vibrio cholerae infection_Homo sapiens_hsa051101.13556610
36Butanoate metabolism_Homo sapiens_hsa006501.07351224
37mRNA surveillance pathway_Homo sapiens_hsa030151.04940395
38Synaptic vesicle cycle_Homo sapiens_hsa047210.96868084
39Oocyte meiosis_Homo sapiens_hsa041140.95899960
40Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.95315127
41Sulfur relay system_Homo sapiens_hsa041220.94260989
42Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.87870418
43Selenocompound metabolism_Homo sapiens_hsa004500.86599575
44Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.85810756
45* Metabolic pathways_Homo sapiens_hsa011000.84685056
46Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.81073946
47Taste transduction_Homo sapiens_hsa047420.78510530
48Serotonergic synapse_Homo sapiens_hsa047260.76315270
49Fatty acid metabolism_Homo sapiens_hsa012120.70860863
50Fatty acid degradation_Homo sapiens_hsa000710.70675355
51Phenylalanine metabolism_Homo sapiens_hsa003600.68778643
52Peroxisome_Homo sapiens_hsa041460.65747125
53Tyrosine metabolism_Homo sapiens_hsa003500.64426392
54GABAergic synapse_Homo sapiens_hsa047270.63911692
55Pyrimidine metabolism_Homo sapiens_hsa002400.63705107
56Rheumatoid arthritis_Homo sapiens_hsa053230.63186961
57Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.63151807
58Morphine addiction_Homo sapiens_hsa050320.63106289
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62874429
60Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.61229789
61Dilated cardiomyopathy_Homo sapiens_hsa054140.61030680
62Calcium signaling pathway_Homo sapiens_hsa040200.57492765
63Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.57475028
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.57097210
65Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56347421
66Arginine biosynthesis_Homo sapiens_hsa002200.55384167
67Circadian entrainment_Homo sapiens_hsa047130.55017986
68Phototransduction_Homo sapiens_hsa047440.54859521
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53061279
70Amphetamine addiction_Homo sapiens_hsa050310.52806463
71Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.52586115
72Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52042890
73Long-term potentiation_Homo sapiens_hsa047200.51204128
74Glutathione metabolism_Homo sapiens_hsa004800.50663262
75Purine metabolism_Homo sapiens_hsa002300.50635874
76Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50228254
77Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49783176
78Pentose phosphate pathway_Homo sapiens_hsa000300.49124952
79Renin secretion_Homo sapiens_hsa049240.48890678
80Dopaminergic synapse_Homo sapiens_hsa047280.48691741
81Cysteine and methionine metabolism_Homo sapiens_hsa002700.48457598
82Glutamatergic synapse_Homo sapiens_hsa047240.48093336
83Nitrogen metabolism_Homo sapiens_hsa009100.48012826
84Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.45304659
85Salivary secretion_Homo sapiens_hsa049700.44885366
86N-Glycan biosynthesis_Homo sapiens_hsa005100.44446858
87Long-term depression_Homo sapiens_hsa047300.42311019
88Olfactory transduction_Homo sapiens_hsa047400.40881018
89Drug metabolism - other enzymes_Homo sapiens_hsa009830.40155723
90Biosynthesis of amino acids_Homo sapiens_hsa012300.37874721
91Arginine and proline metabolism_Homo sapiens_hsa003300.35089939
92Ether lipid metabolism_Homo sapiens_hsa005650.34469389
93Arachidonic acid metabolism_Homo sapiens_hsa005900.34372373
94Phagosome_Homo sapiens_hsa041450.33920826
95Fructose and mannose metabolism_Homo sapiens_hsa000510.33387582
96* p53 signaling pathway_Homo sapiens_hsa041150.32612059
97Gastric acid secretion_Homo sapiens_hsa049710.32506336
98Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.32445459
99Epstein-Barr virus infection_Homo sapiens_hsa051690.30984421
100beta-Alanine metabolism_Homo sapiens_hsa004100.30357254
101SNARE interactions in vesicular transport_Homo sapiens_hsa041300.28758877
102Steroid biosynthesis_Homo sapiens_hsa001000.28264564
103Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.25489904
104Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.25175906
105Circadian rhythm_Homo sapiens_hsa047100.22370102
106Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.22075258
107Oxytocin signaling pathway_Homo sapiens_hsa049210.22052611
108Vascular smooth muscle contraction_Homo sapiens_hsa042700.20849692
109Cholinergic synapse_Homo sapiens_hsa047250.20417493
110Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.20416893
111cGMP-PKG signaling pathway_Homo sapiens_hsa040220.19523274
112Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.18796216
113Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.18393372
114Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.18215504
115Tryptophan metabolism_Homo sapiens_hsa003800.18019993
116PPAR signaling pathway_Homo sapiens_hsa033200.17984486
117Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.17482232
118Basal transcription factors_Homo sapiens_hsa030220.17457466
119Histidine metabolism_Homo sapiens_hsa003400.17298941
120Linoleic acid metabolism_Homo sapiens_hsa005910.15814087
121Regulation of autophagy_Homo sapiens_hsa041400.15584813
122Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.14779924
123Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.13566357
124Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.13150942
125Starch and sucrose metabolism_Homo sapiens_hsa005000.13145845
126Nucleotide excision repair_Homo sapiens_hsa034200.12484205
127Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.11954147
128Mineral absorption_Homo sapiens_hsa049780.11419559
129RNA degradation_Homo sapiens_hsa030180.11041620
130Vitamin B6 metabolism_Homo sapiens_hsa007500.10340938
131Glucagon signaling pathway_Homo sapiens_hsa049220.09380118
132Insulin secretion_Homo sapiens_hsa049110.08545894
133Homologous recombination_Homo sapiens_hsa034400.08223367
134Thyroid cancer_Homo sapiens_hsa052160.07671827
135Tight junction_Homo sapiens_hsa045300.07496917
136Gap junction_Homo sapiens_hsa045400.07423150
137Galactose metabolism_Homo sapiens_hsa000520.06395236
138Alcoholism_Homo sapiens_hsa050340.05771020
139Vitamin digestion and absorption_Homo sapiens_hsa049770.05051488
140Fat digestion and absorption_Homo sapiens_hsa049750.04213902
141Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.04009729

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