CYCSP10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1kinetochore assembly (GO:0051382)5.55693504
2regulation of centriole replication (GO:0046599)5.32120340
3kinetochore organization (GO:0051383)5.26264451
4proteasome assembly (GO:0043248)5.16604016
5viral mRNA export from host cell nucleus (GO:0046784)4.73892158
6positive regulation of megakaryocyte differentiation (GO:0045654)4.53390415
7DNA strand elongation involved in DNA replication (GO:0006271)4.53272436
8protein K6-linked ubiquitination (GO:0085020)4.42238543
9telomere maintenance via semi-conservative replication (GO:0032201)4.29781146
10DNA strand elongation (GO:0022616)4.23919810
11positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)4.22100117
12regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)4.22100117
13protein localization to kinetochore (GO:0034501)4.21213443
14nucleobase biosynthetic process (GO:0046112)4.15376367
15positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)4.12770789
16DNA ligation (GO:0006266)4.08953439
17meiotic chromosome segregation (GO:0045132)4.03481818
18DNA replication-dependent nucleosome assembly (GO:0006335)3.99818246
19DNA replication-dependent nucleosome organization (GO:0034723)3.99818246
20telomere maintenance via recombination (GO:0000722)3.96381606
21synapsis (GO:0007129)3.96044564
22mitotic recombination (GO:0006312)3.94572737
23mitotic nuclear envelope disassembly (GO:0007077)3.91999566
24GMP metabolic process (GO:0046037)3.91264756
25purine nucleobase biosynthetic process (GO:0009113)3.89959844
26regulation of double-strand break repair via homologous recombination (GO:0010569)3.87098138
27nuclear pore organization (GO:0006999)3.80636566
28DNA unwinding involved in DNA replication (GO:0006268)3.79041446
29DNA topological change (GO:0006265)3.75342505
30DNA replication checkpoint (GO:0000076)3.72108881
31nuclear pore complex assembly (GO:0051292)3.68413142
32membrane disassembly (GO:0030397)3.60012645
33nuclear envelope disassembly (GO:0051081)3.60012645
34chromatin remodeling at centromere (GO:0031055)3.58903645
35negative regulation of mRNA processing (GO:0050686)3.58005960
36mitotic sister chromatid cohesion (GO:0007064)3.57564059
37DNA double-strand break processing (GO:0000729)3.56315522
38metaphase plate congression (GO:0051310)3.56005666
39mitotic metaphase plate congression (GO:0007080)3.53546976
40mitotic sister chromatid segregation (GO:0000070)3.51618685
41negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.51497830
42DNA replication initiation (GO:0006270)3.51144036
43CENP-A containing nucleosome assembly (GO:0034080)3.49065691
44establishment of integrated proviral latency (GO:0075713)3.46646492
45regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.45267500
46sister chromatid segregation (GO:0000819)3.43935183
47resolution of meiotic recombination intermediates (GO:0000712)3.42768663
48regulation of centrosome duplication (GO:0010824)3.41209411
49regulation of centrosome cycle (GO:0046605)3.36794593
50protein localization to chromosome, centromeric region (GO:0071459)3.34044510
51IMP biosynthetic process (GO:0006188)3.32952321
52replication fork processing (GO:0031297)3.30370090
53branching involved in prostate gland morphogenesis (GO:0060442)3.29992183
54maturation of 5.8S rRNA (GO:0000460)3.25692389
55alternative mRNA splicing, via spliceosome (GO:0000380)3.24812604
56nucleotide-excision repair, DNA gap filling (GO:0006297)3.24042990
57regulation of translational fidelity (GO:0006450)3.18516100
58histone exchange (GO:0043486)3.18425544
59exocrine pancreas development (GO:0031017)3.17923476
60centriole replication (GO:0007099)3.12198891
61folic acid metabolic process (GO:0046655)3.10983406
62double-strand break repair via nonhomologous end joining (GO:0006303)3.10474975
63non-recombinational repair (GO:0000726)3.10474975
64telomere maintenance via telomere lengthening (GO:0010833)3.10356716
65chromosome segregation (GO:0007059)3.07591132
66double-strand break repair via homologous recombination (GO:0000724)3.07463031
67recombinational repair (GO:0000725)3.05722989
68mitotic chromosome condensation (GO:0007076)3.04793623
69negative regulation of mRNA metabolic process (GO:1903312)3.02145656
70microtubule depolymerization (GO:0007019)3.02107457
71DNA catabolic process, exonucleolytic (GO:0000738)3.01695107
72negative regulation of RNA splicing (GO:0033119)2.89667561
73DNA synthesis involved in DNA repair (GO:0000731)2.88095934
74pore complex assembly (GO:0046931)2.87151412
75regulation of mitotic spindle organization (GO:0060236)2.86830437
76maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.86461370
77positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.86286472
78IMP metabolic process (GO:0046040)2.84372091
79cell cycle G1/S phase transition (GO:0044843)2.76374068
80G1/S transition of mitotic cell cycle (GO:0000082)2.76374068
81DNA strand renaturation (GO:0000733)2.75617954
82negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.75400957
83mitotic cell cycle (GO:0000278)2.75087182
84anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.74595975
85regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.72827620
86pseudouridine synthesis (GO:0001522)2.70862442
87rRNA processing (GO:0006364)2.70570642
88regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.70243134
89regulation of mitotic spindle checkpoint (GO:1903504)2.70243134
90ATP hydrolysis coupled proton transport (GO:0015991)2.68677441
91energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.68677441
92protein localization to chromosome (GO:0034502)2.66919783
93regulation of double-strand break repair (GO:2000779)2.66872297
94chaperone-mediated protein transport (GO:0072321)2.66795513
95rRNA metabolic process (GO:0016072)2.66747493
96RNA export from nucleus (GO:0006405)2.66687337
97establishment of chromosome localization (GO:0051303)2.66655626
98chromosome organization involved in meiosis (GO:0070192)2.65775669
99regulation of exit from mitosis (GO:0007096)2.64820964
100homocysteine metabolic process (GO:0050667)2.64583634

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F4_17652178_ChIP-ChIP_JURKAT_Human4.99324419
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.45559173
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.01502346
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.69368147
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.65860212
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.41633793
7ETS1_20019798_ChIP-Seq_JURKAT_Human2.85851977
8CREB1_15753290_ChIP-ChIP_HEK293T_Human2.80570411
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.80482460
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.77774089
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.71454162
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.68466189
13ELK1_19687146_ChIP-ChIP_HELA_Human2.51294685
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.45090369
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.41493199
16E2F1_21310950_ChIP-Seq_MCF-7_Human2.38173163
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.35176596
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.32971735
19KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.31086654
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.27230322
21SALL1_21062744_ChIP-ChIP_HESCs_Human2.24501149
22AR_21909140_ChIP-Seq_LNCAP_Human2.21720909
23DCP1A_22483619_ChIP-Seq_HELA_Human2.11251911
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.05364709
25E2F7_22180533_ChIP-Seq_HELA_Human10.0371830
26FOXP3_21729870_ChIP-Seq_TREG_Human1.96911907
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.93069532
28FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.92706327
29EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.86715572
30YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.82672860
31ZNF274_21170338_ChIP-Seq_K562_Hela1.81680489
32PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.79779786
33MYCN_18555785_ChIP-Seq_MESCs_Mouse1.78531532
34GABP_19822575_ChIP-Seq_HepG2_Human1.76108464
35TTF2_22483619_ChIP-Seq_HELA_Human1.74802166
36TP63_19390658_ChIP-ChIP_HaCaT_Human1.74648750
37VDR_23849224_ChIP-Seq_CD4+_Human1.74244866
38PADI4_21655091_ChIP-ChIP_MCF-7_Human1.73319243
39MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.69897076
40ESR1_15608294_ChIP-ChIP_MCF-7_Human1.69374984
41KDM5A_27292631_Chip-Seq_BREAST_Human1.63341406
42MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.63273344
43SRF_21415370_ChIP-Seq_HL-1_Mouse1.59459590
44THAP11_20581084_ChIP-Seq_MESCs_Mouse1.56438965
45NELFA_20434984_ChIP-Seq_ESCs_Mouse1.56054640
46E2F1_18555785_ChIP-Seq_MESCs_Mouse1.52540849
47NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.50613669
48POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.49142749
49RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45445360
50XRN2_22483619_ChIP-Seq_HELA_Human1.43201584
51FUS_26573619_Chip-Seq_HEK293_Human1.42995474
52EWS_26573619_Chip-Seq_HEK293_Human1.39605541
53GATA1_26923725_Chip-Seq_HPCs_Mouse1.36196418
54E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.32978450
55VDR_22108803_ChIP-Seq_LS180_Human1.30387164
56CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.28909745
57MYC_18940864_ChIP-ChIP_HL60_Human1.24894081
58SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.24245370
59YY1_21170310_ChIP-Seq_MESCs_Mouse1.23925574
60POU5F1_16153702_ChIP-ChIP_HESCs_Human1.20095740
61AR_21572438_ChIP-Seq_LNCaP_Human1.16495444
62HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.16086202
63HOXB4_20404135_ChIP-ChIP_EML_Mouse1.16038748
64ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.13511517
65NANOG_16153702_ChIP-ChIP_HESCs_Human1.06182555
66POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.05007413
67CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.02712040
68CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.00095430
69NANOG_18555785_ChIP-Seq_MESCs_Mouse0.98109219
70RBPJ_22232070_ChIP-Seq_NCS_Mouse0.96040870
71SOX2_16153702_ChIP-ChIP_HESCs_Human0.94178305
72CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.88853625
73TFEB_21752829_ChIP-Seq_HELA_Human0.88571496
74CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.87689246
75IRF1_19129219_ChIP-ChIP_H3396_Human0.86639806
76BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.86579036
77ZFX_18555785_ChIP-Seq_MESCs_Mouse0.86096080
78SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.84865745
79CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.81984045
80GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.78900731
81STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.76437886
82SOX2_18555785_ChIP-Seq_MESCs_Mouse0.76232405
83KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.76228859
84NANOG_21062744_ChIP-ChIP_HESCs_Human0.76168026
85E2F1_17053090_ChIP-ChIP_MCF-7_Human0.75418837
86PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.74114038
87TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.72041211
88EGR1_19374776_ChIP-ChIP_THP-1_Human0.70479501
89ERG_20887958_ChIP-Seq_HPC-7_Mouse0.70229675
90HOXB7_26014856_ChIP-Seq_BT474_Human0.69563831
91ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.68435110
92RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.67895960
93EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.67856491
94ELF5_23300383_ChIP-Seq_T47D_Human0.67526883
95GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.65968108
96CIITA_25753668_ChIP-Seq_RAJI_Human0.65195299
97NOTCH1_21737748_ChIP-Seq_TLL_Human0.65155573
98FOXA1_25329375_ChIP-Seq_VCAP_Human0.63721711
99FOXA1_27270436_Chip-Seq_PROSTATE_Human0.63721711
100PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.62659815

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat6.46505103
2MP0010094_abnormal_chromosome_stability4.48285015
3MP0008058_abnormal_DNA_repair4.00165575
4MP0003111_abnormal_nucleus_morphology3.27360680
5MP0001346_abnormal_lacrimal_gland3.26573064
6MP0003136_yellow_coat_color3.11611841
7MP0001873_stomach_inflammation2.79707197
8MP0005377_hearing/vestibular/ear_phenot2.69340319
9MP0003878_abnormal_ear_physiology2.69340319
10MP0004957_abnormal_blastocyst_morpholog2.60881134
11MP0002876_abnormal_thyroid_physiology2.48155038
12MP0003693_abnormal_embryo_hatching2.43903609
13MP0003077_abnormal_cell_cycle2.37823455
14MP0009697_abnormal_copulation2.23326277
15MP0003786_premature_aging2.21607118
16MP0008995_early_reproductive_senescence2.20657400
17MP0000427_abnormal_hair_cycle2.01838543
18MP0000537_abnormal_urethra_morphology1.94745090
19MP0008877_abnormal_DNA_methylation1.93763410
20MP0000383_abnormal_hair_follicle1.93492150
21MP0005187_abnormal_penis_morphology1.91515895
22MP0008057_abnormal_DNA_replication1.90397912
23MP0000516_abnormal_urinary_system1.86554969
24MP0005367_renal/urinary_system_phenotyp1.86554969
25MP0008007_abnormal_cellular_replicative1.85167310
26MP0001293_anophthalmia1.81754288
27MP0003315_abnormal_perineum_morphology1.80150866
28MP0006035_abnormal_mitochondrial_morpho1.79923833
29MP0008932_abnormal_embryonic_tissue1.77532362
30MP0001348_abnormal_lacrimal_gland1.76246436
31MP0003937_abnormal_limbs/digits/tail_de1.70334157
32MP0006036_abnormal_mitochondrial_physio1.68259948
33MP0002396_abnormal_hematopoietic_system1.66084502
34MP0000015_abnormal_ear_pigmentation1.58262602
35MP0002095_abnormal_skin_pigmentation1.55570956
36MP0003950_abnormal_plasma_membrane1.54049366
37MP0010307_abnormal_tumor_latency1.47770935
38MP0008872_abnormal_physiological_respon1.46517823
39MP0002210_abnormal_sex_determination1.43233367
40MP0005075_abnormal_melanosome_morpholog1.38648770
41MP0000372_irregular_coat_pigmentation1.37106110
42MP0000647_abnormal_sebaceous_gland1.30393373
43MP0001929_abnormal_gametogenesis1.29100535
44MP0005197_abnormal_uvea_morphology1.24452644
45MP0001697_abnormal_embryo_size1.22327062
46MP0001730_embryonic_growth_arrest1.21867003
47MP0002938_white_spotting1.19067291
48MP0001145_abnormal_male_reproductive1.15400235
49MP0006292_abnormal_olfactory_placode1.11961388
50MP0003718_maternal_effect1.11481406
51MP0004782_abnormal_surfactant_physiolog1.08291984
52MP0000538_abnormal_urinary_bladder1.08265696
53MP0003698_abnormal_male_reproductive1.07235193
54MP0003186_abnormal_redox_activity1.07203308
55MP0004381_abnormal_hair_follicle1.05368376
56MP0000653_abnormal_sex_gland1.05265735
57MP0005310_abnormal_salivary_gland0.95843960
58MP0005645_abnormal_hypothalamus_physiol0.94265832
59MP0002085_abnormal_embryonic_tissue0.93912330
60MP0005380_embryogenesis_phenotype0.93363200
61MP0001672_abnormal_embryogenesis/_devel0.93363200
62MP0000350_abnormal_cell_proliferation0.93108047
63MP0004043_abnormal_pH_regulation0.91913956
64MP0000358_abnormal_cell_content/0.90177158
65MP0005410_abnormal_fertilization0.89168469
66MP0003567_abnormal_fetal_cardiomyocyte0.88588519
67MP0005408_hypopigmentation0.88587203
68MP0001119_abnormal_female_reproductive0.88385480
69MP0004197_abnormal_fetal_growth/weight/0.87298701
70MP0010678_abnormal_skin_adnexa0.85462635
71MP0003984_embryonic_growth_retardation0.84776800
72MP0002080_prenatal_lethality0.83548505
73MP0002088_abnormal_embryonic_growth/wei0.78848697
74MP0000313_abnormal_cell_death0.77330836
75MP0002098_abnormal_vibrissa_morphology0.76560160
76MP0005647_abnormal_sex_gland0.75954490
77MP0000467_abnormal_esophagus_morphology0.75618148
78MP0009672_abnormal_birth_weight0.74965734
79MP0002086_abnormal_extraembryonic_tissu0.74285116
80MP0005084_abnormal_gallbladder_morpholo0.72422351
81MP0003943_abnormal_hepatobiliary_system0.71600943
82MP0002019_abnormal_tumor_incidence0.70703606
83MP0001177_atelectasis0.70370308
84MP0003646_muscle_fatigue0.69420998
85MP0008770_decreased_survivor_rate0.68691129
86MP0009379_abnormal_foot_pigmentation0.67800171
87MP0002161_abnormal_fertility/fecundity0.67704210
88MP0002084_abnormal_developmental_patter0.67634267
89MP0001661_extended_life_span0.66144096
90MP0010352_gastrointestinal_tract_polyps0.64885225
91MP0000566_synostosis0.61327309
92MP0000613_abnormal_salivary_gland0.60723469
93MP0002075_abnormal_coat/hair_pigmentati0.59749695
94MP0002233_abnormal_nose_morphology0.59114091
95MP0000639_abnormal_adrenal_gland0.59104610
96MP0003938_abnormal_ear_development0.58877519
97MP0010030_abnormal_orbit_morphology0.58170520
98MP0009278_abnormal_bone_marrow0.58075761
99MP0001905_abnormal_dopamine_level0.57791090
100MP0003699_abnormal_female_reproductive0.57697023

Predicted human phenotypes

RankGene SetZ-score
1Increased circulating renin level (HP:0000848)6.63211423
2Short 1st metacarpal (HP:0010034)5.25701004
3Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)5.25701004
4Bilateral sensorineural hearing impairment (HP:0008619)5.16846571
5Chromosomal breakage induced by crosslinking agents (HP:0003221)5.07318764
6Hypokalemic alkalosis (HP:0001949)4.57448916
7Abnormality of the 1st metacarpal (HP:0010009)4.56762787
8Chromsome breakage (HP:0040012)4.51028610
9Hypomagnesemia (HP:0002917)4.45190089
10Tetany (HP:0001281)4.41593095
11Septate vagina (HP:0001153)4.33641143
12Paralysis (HP:0003470)4.09906322
13Abnormality of magnesium homeostasis (HP:0004921)3.82951567
14Abnormal drinking behavior (HP:0030082)3.81852703
15Polydipsia (HP:0001959)3.81852703
16Abnormality of the ileum (HP:0001549)3.46684479
17Meckel diverticulum (HP:0002245)3.38838795
18Abnormality of the preputium (HP:0100587)3.37102108
19Aplasia/Hypoplasia of the uvula (HP:0010293)3.21546735
20Short phalanx of the thumb (HP:0009660)3.20738693
21Abnormal tarsal ossification (HP:0008369)3.13422380
22Amelogenesis imperfecta (HP:0000705)3.04849927
23Abnormality of chromosome stability (HP:0003220)3.04733168
24Polyuria (HP:0000103)2.79757987
25Dyschromatopsia (HP:0007641)2.79135636
26Abnormality of renin-angiotensin system (HP:0000847)2.77229198
27Renal tubular acidosis (HP:0001947)2.70971679
28Duodenal stenosis (HP:0100867)2.69055097
29Small intestinal stenosis (HP:0012848)2.69055097
30Abnormality of the 2nd finger (HP:0004100)2.68590951
31Spontaneous abortion (HP:0005268)2.64722647
32Sloping forehead (HP:0000340)2.61270406
33Asplenia (HP:0001746)2.53003600
34Short thumb (HP:0009778)2.52865540
35Long clavicles (HP:0000890)2.46935702
36Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.45625150
37Abnormality of the carotid arteries (HP:0005344)2.43049078
38Abnormality of glycolysis (HP:0004366)2.42528355
39Myelodysplasia (HP:0002863)2.40956078
40Aplasia/Hypoplasia of the spleen (HP:0010451)2.38883588
41Horseshoe kidney (HP:0000085)2.35851340
42Cerebellar dysplasia (HP:0007033)2.33150327
43Birth length less than 3rd percentile (HP:0003561)2.29625956
44Alkalosis (HP:0001948)2.28180100
45Short middle phalanx of finger (HP:0005819)2.27684478
46Abnormality of the labia minora (HP:0012880)2.27040653
47Abnormal foot bone ossification (HP:0010675)2.25288071
48Abnormal urine output (HP:0012590)2.23977912
49Duplicated collecting system (HP:0000081)2.23352680
50High anterior hairline (HP:0009890)2.20842572
51Increased serum pyruvate (HP:0003542)2.14553608
52Septo-optic dysplasia (HP:0100842)2.14186349
53Abnormality of the duodenum (HP:0002246)2.13811722
54Ectopic kidney (HP:0000086)2.10592984
55Decreased electroretinogram (ERG) amplitude (HP:0000654)2.10190571
56Abnormality of cochlea (HP:0000375)2.06803985
57Colon cancer (HP:0003003)2.06185108
58Short 5th finger (HP:0009237)2.05306716
59Absent rod-and cone-mediated responses on ERG (HP:0007688)2.05216753
60Abnormality of the renal collecting system (HP:0004742)2.04555362
61Patellar aplasia (HP:0006443)2.04112049
62Clubbing of toes (HP:0100760)2.03865061
63Delayed CNS myelination (HP:0002188)2.02192251
643-Methylglutaconic aciduria (HP:0003535)2.01692055
65Hypoparathyroidism (HP:0000829)1.98478954
66Molar tooth sign on MRI (HP:0002419)1.97991071
67Abnormality of midbrain morphology (HP:0002418)1.97991071
68Increased nuchal translucency (HP:0010880)1.95137341
69Ureteral duplication (HP:0000073)1.93618437
70Recurrent cutaneous fungal infections (HP:0011370)1.92924661
71Chronic mucocutaneous candidiasis (HP:0002728)1.92924661
72Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.90460666
73Type I transferrin isoform profile (HP:0003642)1.86737712
74Nephronophthisis (HP:0000090)1.83974305
75Aplasia/Hypoplasia of the patella (HP:0006498)1.82011571
76Abnormality of renal excretion (HP:0011036)1.81006564
77Hypokalemia (HP:0002900)1.78903209
78Abnormality of endocrine pancreas physiology (HP:0012093)1.78900257
79Abnormality of the pancreatic islet cells (HP:0006476)1.78900257
80Ureteral stenosis (HP:0000071)1.74436457
81Morphological abnormality of the inner ear (HP:0011390)1.74299149
82Cleft eyelid (HP:0000625)1.73190851
83Neoplasm of the adrenal cortex (HP:0100641)1.71911492
84Generalized muscle weakness (HP:0003324)1.71694974
85High pitched voice (HP:0001620)1.70685333
86Renal tubular dysfunction (HP:0000124)1.70646108
87Methylmalonic acidemia (HP:0002912)1.70585031
88Unilateral renal agenesis (HP:0000122)1.68754256
89Cortical dysplasia (HP:0002539)1.68710353
90Cafe-au-lait spot (HP:0000957)1.67715149
91Arteriovenous malformation (HP:0100026)1.67462167
92Abnormality of DNA repair (HP:0003254)1.66792341
93Flat capital femoral epiphysis (HP:0003370)1.66644033
94Cholelithiasis (HP:0001081)1.66009567
95Abnormality of dental color (HP:0011073)1.65305765
96Absent radius (HP:0003974)1.64515209
97Abnormality of homocysteine metabolism (HP:0010919)1.63887049
98Homocystinuria (HP:0002156)1.63887049
99Nephroblastoma (Wilms tumor) (HP:0002667)1.61454321
100Blepharitis (HP:0000498)1.61069356

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK48.68913909
2STK398.33916425
3OXSR16.09047735
4TNIK2.44278341
5CDC72.24931915
6VRK22.23121610
7PLK41.97212311
8TTK1.79886892
9EIF2AK11.75248960
10EIF2AK31.64376501
11PRKD31.60706718
12TAF11.51043737
13NEK11.48302622
14WEE11.45651689
15PLK21.40240604
16NUAK11.32461954
17BRSK21.31559206
18CCNB11.28991173
19PLK31.27515576
20MKNK21.22983033
21CHEK21.19596886
22ATR1.19183849
23MKNK11.16808674
24PBK1.13727581
25PLK11.07227123
26VRK11.04803745
27EIF2AK21.00520285
28NME10.99590365
29MAP2K70.99232619
30BUB10.92271158
31SRPK10.90973499
32BRD40.89882297
33TSSK60.86948875
34MST40.83899446
35MAP3K40.82077057
36ZAK0.77359994
37STK160.76238346
38ERBB40.75271810
39STK100.73042660
40BRSK10.69801922
41MAP3K60.68705863
42AURKB0.66850957
43BMPR1B0.63963038
44TNK20.61822379
45PIK3CA0.61481470
46CHEK10.58300638
47PRKG20.54924930
48LATS20.54753871
49PTK2B0.54350490
50ATM0.52760090
51NEK20.52206164
52DYRK20.49551290
53CDK80.48274726
54RPS6KB20.46346696
55CDK10.46345724
56CDK120.46194437
57TIE10.43324169
58WNK30.42563674
59DAPK10.41424477
60PKN20.40069192
61AKT30.39308008
62NLK0.38916557
63CAMK1D0.38605786
64PKN10.37172303
65DMPK0.36415260
66STK40.34989066
67CSNK2A10.32942112
68FLT30.32664000
69CDK30.31363775
70ALK0.31259735
71RET0.31160724
72CDK70.30198338
73PINK10.30192958
74MAPK130.29539864
75CDK20.29283059
76PRKDC0.28294452
77PDK20.27613823
78CSNK2A20.25297303
79FGFR10.24408462
80MAP2K40.23443116
81MARK30.22116252
82PAK10.21701414
83AURKA0.21183132
84GRK50.19593471
85CSNK1G10.19367996
86CDK40.19014007
87CLK10.17837416
88RAF10.17488635
89CSNK1E0.17367850
90ADRBK10.16129393
91CAMK1G0.16013076
92PRKCH0.15012223
93SCYL20.14738459
94RPS6KA40.14663040
95MAPK140.14633084
96MAP3K80.10744860
97GRK70.10079069
98MTOR0.09632726
99KDR0.09534928
100STK30.09150478

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.95683493
2Mismatch repair_Homo sapiens_hsa034304.06809603
3Homologous recombination_Homo sapiens_hsa034403.68245225
4Fanconi anemia pathway_Homo sapiens_hsa034603.60900425
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.51485568
6Collecting duct acid secretion_Homo sapiens_hsa049663.38093713
7Proteasome_Homo sapiens_hsa030503.27045440
8One carbon pool by folate_Homo sapiens_hsa006702.86875509
9Nucleotide excision repair_Homo sapiens_hsa034202.69133976
10RNA transport_Homo sapiens_hsa030132.67990372
11Basal transcription factors_Homo sapiens_hsa030222.44042831
12Spliceosome_Homo sapiens_hsa030402.40916744
13Non-homologous end-joining_Homo sapiens_hsa034502.40503278
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.33724418
15Base excision repair_Homo sapiens_hsa034102.31592375
16Cell cycle_Homo sapiens_hsa041101.87584226
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.68293282
18RNA polymerase_Homo sapiens_hsa030201.67505277
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.49672976
20mRNA surveillance pathway_Homo sapiens_hsa030151.48289006
21RNA degradation_Homo sapiens_hsa030181.47416930
22Pyrimidine metabolism_Homo sapiens_hsa002401.44569866
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.34101222
24Oxidative phosphorylation_Homo sapiens_hsa001901.23115151
25Propanoate metabolism_Homo sapiens_hsa006401.22232200
26Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.18154036
27Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.17201617
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.11891011
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.11180366
30Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.07682405
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.03404288
32Cyanoamino acid metabolism_Homo sapiens_hsa004601.01429163
33Olfactory transduction_Homo sapiens_hsa047401.00572230
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.99159534
35Huntingtons disease_Homo sapiens_hsa050160.98454868
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.97169549
37Protein export_Homo sapiens_hsa030600.96445495
38Fatty acid elongation_Homo sapiens_hsa000620.96070412
39Nitrogen metabolism_Homo sapiens_hsa009100.93030080
40Biosynthesis of amino acids_Homo sapiens_hsa012300.92794540
41Vibrio cholerae infection_Homo sapiens_hsa051100.89767852
42Ribosome_Homo sapiens_hsa030100.88636084
43Synaptic vesicle cycle_Homo sapiens_hsa047210.88112738
44Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.86423141
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.86035299
46Vitamin B6 metabolism_Homo sapiens_hsa007500.85477685
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.85189269
48Butanoate metabolism_Homo sapiens_hsa006500.81590615
49Drug metabolism - other enzymes_Homo sapiens_hsa009830.81370720
50Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.81314195
51Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.78469911
52Fatty acid metabolism_Homo sapiens_hsa012120.76205049
53Purine metabolism_Homo sapiens_hsa002300.75648803
54Regulation of autophagy_Homo sapiens_hsa041400.72980024
55Pyruvate metabolism_Homo sapiens_hsa006200.72044386
56Carbon metabolism_Homo sapiens_hsa012000.67525709
57Glutathione metabolism_Homo sapiens_hsa004800.65109900
58N-Glycan biosynthesis_Homo sapiens_hsa005100.65049271
59Lysine degradation_Homo sapiens_hsa003100.60444958
60Pentose phosphate pathway_Homo sapiens_hsa000300.60264815
61Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59958014
62Parkinsons disease_Homo sapiens_hsa050120.58474662
63Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57109007
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.55713367
65Peroxisome_Homo sapiens_hsa041460.53307308
66Fructose and mannose metabolism_Homo sapiens_hsa000510.52474168
67Hedgehog signaling pathway_Homo sapiens_hsa043400.51190382
68Rheumatoid arthritis_Homo sapiens_hsa053230.50962101
69Metabolic pathways_Homo sapiens_hsa011000.49452012
70Basal cell carcinoma_Homo sapiens_hsa052170.48574483
71Taste transduction_Homo sapiens_hsa047420.47488751
72Ether lipid metabolism_Homo sapiens_hsa005650.45577315
73Oocyte meiosis_Homo sapiens_hsa041140.43653613
74Herpes simplex infection_Homo sapiens_hsa051680.39737704
75Folate biosynthesis_Homo sapiens_hsa007900.35942951
76Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32633954
77Tyrosine metabolism_Homo sapiens_hsa003500.31674929
78Steroid biosynthesis_Homo sapiens_hsa001000.31066130
79Fatty acid degradation_Homo sapiens_hsa000710.30272016
80Epstein-Barr virus infection_Homo sapiens_hsa051690.29197311
81Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.27767333
82Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.27376621
83Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.27188441
84Maturity onset diabetes of the young_Homo sapiens_hsa049500.27064048
85Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.24372308
86Selenocompound metabolism_Homo sapiens_hsa004500.24061847
87Fatty acid biosynthesis_Homo sapiens_hsa000610.22964112
88HIF-1 signaling pathway_Homo sapiens_hsa040660.22760464
89Fat digestion and absorption_Homo sapiens_hsa049750.22396479
90Phototransduction_Homo sapiens_hsa047440.22315240
91Thyroid cancer_Homo sapiens_hsa052160.20048065
92Phenylalanine metabolism_Homo sapiens_hsa003600.18737839
93Primary immunodeficiency_Homo sapiens_hsa053400.18704407
94Glycerolipid metabolism_Homo sapiens_hsa005610.17807228
95Galactose metabolism_Homo sapiens_hsa000520.17231644
96beta-Alanine metabolism_Homo sapiens_hsa004100.15164829
97Alzheimers disease_Homo sapiens_hsa050100.10532103
98Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.09823772
99MicroRNAs in cancer_Homo sapiens_hsa052060.06058939
100Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.05788319

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