CYCSP24

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1melanin biosynthetic process (GO:0042438)6.68797336
2regulation of mitotic spindle checkpoint (GO:1903504)6.59532579
3regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)6.59532579
4melanin metabolic process (GO:0006582)6.10816002
5positive regulation of cell cycle checkpoint (GO:1901978)5.91815298
6secondary metabolite biosynthetic process (GO:0044550)5.90298263
7sympathetic nervous system development (GO:0048485)5.49803350
8replication fork processing (GO:0031297)5.38321909
9phosphate ion homeostasis (GO:0055062)4.73710474
10trivalent inorganic anion homeostasis (GO:0072506)4.73710474
11collecting duct development (GO:0072044)4.64846504
12platelet dense granule organization (GO:0060155)4.50816670
13microtubule severing (GO:0051013)4.44294591
14cellular anion homeostasis (GO:0030002)4.35111811
15protein deneddylation (GO:0000338)4.20359837
16cullin deneddylation (GO:0010388)4.18446048
17positive regulation of urine volume (GO:0035810)4.05852976
18regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.97129206
19proteasome assembly (GO:0043248)3.91399236
20potassium ion homeostasis (GO:0055075)3.84454380
21regulation of centrosome duplication (GO:0010824)3.80542709
22male meiosis (GO:0007140)3.69290633
23regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.68283229
24mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.66512517
25mitochondrial respiratory chain complex I assembly (GO:0032981)3.66512517
26NADH dehydrogenase complex assembly (GO:0010257)3.66512517
27kinetochore assembly (GO:0051382)3.60179059
28DNA double-strand break processing (GO:0000729)3.58974847
29retina layer formation (GO:0010842)3.51417511
30regulation of spindle checkpoint (GO:0090231)3.46811600
31double-strand break repair via homologous recombination (GO:0000724)3.46481057
32recombinational repair (GO:0000725)3.46371674
33establishment of protein localization to mitochondrial membrane (GO:0090151)3.45966034
34regulation of centrosome cycle (GO:0046605)3.45569046
35maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.44096954
36regulation of male gonad development (GO:2000018)3.42067201
37inositol phosphate catabolic process (GO:0071545)3.35235237
38GMP metabolic process (GO:0046037)3.35213328
39positive regulation by host of viral transcription (GO:0043923)3.33993165
40protein complex biogenesis (GO:0070271)3.32853154
41respiratory chain complex IV assembly (GO:0008535)3.31171217
42regulation of hexokinase activity (GO:1903299)3.30827274
43regulation of glucokinase activity (GO:0033131)3.30827274
44response to pheromone (GO:0019236)3.20054814
45dorsal/ventral axis specification (GO:0009950)3.17917578
46protein K11-linked deubiquitination (GO:0035871)3.13778880
47cytochrome complex assembly (GO:0017004)3.13103754
48regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.12689189
49kinetochore organization (GO:0051383)3.11302410
50embryonic skeletal joint morphogenesis (GO:0060272)3.08868580
51inositol phosphate dephosphorylation (GO:0046855)3.06758659
52phosphorylated carbohydrate dephosphorylation (GO:0046838)3.06758659
53regulation of respiratory system process (GO:0044065)3.06629035
54melanosome organization (GO:0032438)3.03717041
55cornea development in camera-type eye (GO:0061303)3.02280999
56attachment of spindle microtubules to kinetochore (GO:0008608)3.01003097
57DNA integration (GO:0015074)2.98832912
58DNA strand renaturation (GO:0000733)2.97864941
59lactate metabolic process (GO:0006089)2.97037155
60positive regulation of male gonad development (GO:2000020)2.92884555
61mitochondrial respiratory chain complex assembly (GO:0033108)2.92131877
62hindlimb morphogenesis (GO:0035137)2.89527117
63pigment granule organization (GO:0048753)2.88685417
64nephron tubule development (GO:0072080)2.88406107
65resolution of meiotic recombination intermediates (GO:0000712)2.88310437
66peptidyl-histidine modification (GO:0018202)2.87080344
67acrosome reaction (GO:0007340)2.84491730
68melanosome localization (GO:0032400)2.81153532
69presynaptic membrane assembly (GO:0097105)2.79587269
70positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.79164590
71DNA catabolic process, exonucleolytic (GO:0000738)2.77552416
72tyrosine metabolic process (GO:0006570)2.76456417
73renal tubule development (GO:0061326)2.76411983
74C4-dicarboxylate transport (GO:0015740)2.75832117
75signal peptide processing (GO:0006465)2.74712469
76forelimb morphogenesis (GO:0035136)2.73878676
77regulation of action potential (GO:0098900)2.72937673
78phenol-containing compound biosynthetic process (GO:0046189)2.72436449
79regulation of urine volume (GO:0035809)2.72039433
80protein polyglutamylation (GO:0018095)2.72018643
81developmental pigmentation (GO:0048066)2.69649569
82pigment granule localization (GO:0051875)2.69352261
83melanosome transport (GO:0032402)2.69235639
84calcium ion-dependent exocytosis (GO:0017156)2.66038287
85negative regulation of translation, ncRNA-mediated (GO:0040033)2.65935855
86regulation of translation, ncRNA-mediated (GO:0045974)2.65935855
87negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.65935855
88chromatin remodeling at centromere (GO:0031055)2.64835566
89behavioral response to nicotine (GO:0035095)2.64322151
90histone exchange (GO:0043486)2.62825970
91pigment biosynthetic process (GO:0046148)2.61389263
92ketone body metabolic process (GO:1902224)2.61058109
93positive regulation of vesicle fusion (GO:0031340)2.60468516
94organ induction (GO:0001759)2.59266021
95CENP-A containing nucleosome assembly (GO:0034080)2.58645699
96pigment granule transport (GO:0051904)2.56366827
97polyol catabolic process (GO:0046174)2.52811682
98inner mitochondrial membrane organization (GO:0007007)2.51691296
99establishment of melanosome localization (GO:0032401)2.50965995
100sodium ion homeostasis (GO:0055078)2.49540152

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.27545484
2POU3F2_20337985_ChIP-ChIP_501MEL_Human3.00802609
3ZFP57_27257070_Chip-Seq_ESCs_Mouse2.97332767
4ZNF274_21170338_ChIP-Seq_K562_Hela2.72088734
5CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.67490746
6GBX2_23144817_ChIP-Seq_PC3_Human2.60236726
7FUS_26573619_Chip-Seq_HEK293_Human2.48887979
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.45213846
9ER_23166858_ChIP-Seq_MCF-7_Human2.28854973
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.26023310
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.23964912
12TAF15_26573619_Chip-Seq_HEK293_Human2.23594593
13CTBP2_25329375_ChIP-Seq_LNCAP_Human2.18412056
14EWS_26573619_Chip-Seq_HEK293_Human2.17782400
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.11081351
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.05538043
17IGF1R_20145208_ChIP-Seq_DFB_Human2.01481594
18PCGF2_27294783_Chip-Seq_ESCs_Mouse2.00702708
19P300_19829295_ChIP-Seq_ESCs_Human1.96641977
20GABP_17652178_ChIP-ChIP_JURKAT_Human1.95498462
21AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.88543712
22PIAS1_25552417_ChIP-Seq_VCAP_Human1.85022124
23ELK1_19687146_ChIP-ChIP_HELA_Human1.82015635
24BCAT_22108803_ChIP-Seq_LS180_Human1.69527522
25PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69370149
26VDR_22108803_ChIP-Seq_LS180_Human1.68759559
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.67161078
28SUZ12_27294783_Chip-Seq_NPCs_Mouse1.66703276
29EZH2_27294783_Chip-Seq_NPCs_Mouse1.64945732
30SMAD4_21799915_ChIP-Seq_A2780_Human1.62904916
31UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.60800528
32HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.60381511
33MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.56476241
34NOTCH1_21737748_ChIP-Seq_TLL_Human1.55808655
35SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.54397229
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.54316462
37PCGF2_27294783_Chip-Seq_NPCs_Mouse1.54090026
38MYC_18940864_ChIP-ChIP_HL60_Human1.53304362
39OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.53084105
40MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.52517662
41SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50467727
42EST1_17652178_ChIP-ChIP_JURKAT_Human1.49392454
43NFE2_27457419_Chip-Seq_LIVER_Mouse1.49261685
44PADI4_21655091_ChIP-ChIP_MCF-7_Human1.44640095
45CBX2_27304074_Chip-Seq_ESCs_Mouse1.42035455
46RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.41745239
47MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.40160327
48STAT3_23295773_ChIP-Seq_U87_Human1.39358071
49CRX_20693478_ChIP-Seq_RETINA_Mouse1.38972220
50SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.37542457
51NANOG_18555785_Chip-Seq_ESCs_Mouse1.35627788
52CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.35266251
53TP53_22573176_ChIP-Seq_HFKS_Human1.34420810
54EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.34301057
55TCF4_22108803_ChIP-Seq_LS180_Human1.34209460
56CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.33054868
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.31974608
58JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.31426591
59FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.31187577
60AR_25329375_ChIP-Seq_VCAP_Human1.29839366
61GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.29132263
62SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.28854868
63AUTS2_25519132_ChIP-Seq_293T-REX_Human1.28581002
64TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.27737327
65KLF5_20875108_ChIP-Seq_MESCs_Mouse1.27699136
66IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.27332902
67CBP_20019798_ChIP-Seq_JUKART_Human1.27332902
68SOX2_19829295_ChIP-Seq_ESCs_Human1.27319877
69NANOG_19829295_ChIP-Seq_ESCs_Human1.27319877
70EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.27082290
71P53_22387025_ChIP-Seq_ESCs_Mouse1.27045745
72RUNX2_22187159_ChIP-Seq_PCA_Human1.26716983
73TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24531852
74TCF4_23295773_ChIP-Seq_U87_Human1.23981286
75E2F1_18555785_Chip-Seq_ESCs_Mouse1.22569243
76POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.18638839
77ETV2_25802403_ChIP-Seq_MESCs_Mouse1.18601238
78P300_18555785_Chip-Seq_ESCs_Mouse1.17733789
79KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.17473263
80VDR_23849224_ChIP-Seq_CD4+_Human1.17234446
81EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.16784360
82STAT3_18555785_Chip-Seq_ESCs_Mouse1.16648660
83CMYC_18555785_Chip-Seq_ESCs_Mouse1.16565934
84PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.15008225
85E2F4_17652178_ChIP-ChIP_JURKAT_Human1.14796377
86CJUN_26792858_Chip-Seq_BT549_Human1.14215986
87TAL1_26923725_Chip-Seq_HPCs_Mouse1.13565604
88JUN_21703547_ChIP-Seq_K562_Human1.13030531
89OCT4_21477851_ChIP-Seq_ESCs_Mouse1.13001077
90SRF_21415370_ChIP-Seq_HL-1_Mouse1.12745597
91TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.12487264
92KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.12415137
93SUZ12_18555785_Chip-Seq_ESCs_Mouse1.10366328
94NMYC_18555785_Chip-Seq_ESCs_Mouse1.09843979
95FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.09481417
96SOX2_18555785_Chip-Seq_ESCs_Mouse1.09247550
97TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08724516
98RNF2_27304074_Chip-Seq_NSC_Mouse1.07346191
99OCT4_18555785_Chip-Seq_ESCs_Mouse1.07247011
100CDX2_19796622_ChIP-Seq_MESCs_Mouse1.04222704

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000372_irregular_coat_pigmentation4.68263280
2MP0005075_abnormal_melanosome_morpholog4.25711473
3MP0000015_abnormal_ear_pigmentation3.74964543
4MP0000569_abnormal_digit_pigmentation3.60503706
5MP0005171_absent_coat_pigmentation3.59114528
6MP0005408_hypopigmentation3.44271997
7MP0002102_abnormal_ear_morphology2.80934175
8MP0002095_abnormal_skin_pigmentation2.73902309
9MP0005423_abnormal_somatic_nervous2.69105689
10MP0005174_abnormal_tail_pigmentation2.67931092
11MP0001324_abnormal_eye_pigmentation2.65466753
12MP0003646_muscle_fatigue2.61096239
13MP0000371_diluted_coat_color2.52440873
14MP0003195_calcinosis2.27969894
15MP0005257_abnormal_intraocular_pressure2.25371803
16MP0004381_abnormal_hair_follicle2.21341089
17MP0002837_dystrophic_cardiac_calcinosis2.05540244
18MP0003880_abnormal_central_pattern2.03856713
19MP0002938_white_spotting2.01313918
20MP0005367_renal/urinary_system_phenotyp1.97266955
21MP0000516_abnormal_urinary_system1.97266955
22MP0008058_abnormal_DNA_repair1.96395297
23MP0002166_altered_tumor_susceptibility1.83504883
24MP0003567_abnormal_fetal_cardiomyocyte1.68348017
25MP0002006_tumorigenesis1.66155149
26MP0005253_abnormal_eye_physiology1.55542604
27MP0002177_abnormal_outer_ear1.55047721
28MP0010234_abnormal_vibrissa_follicle1.50431539
29MP0002909_abnormal_adrenal_gland1.47198379
30MP0009046_muscle_twitch1.46821594
31MP0006072_abnormal_retinal_apoptosis1.42993995
32MP0002822_catalepsy1.42008066
33MP0005551_abnormal_eye_electrophysiolog1.41419215
34MP0001984_abnormal_olfaction1.41247306
35MP0003136_yellow_coat_color1.38218978
36MP0002282_abnormal_trachea_morphology1.35411796
37MP0001968_abnormal_touch/_nociception1.32721988
38MP0003937_abnormal_limbs/digits/tail_de1.32283264
39MP0002638_abnormal_pupillary_reflex1.31452613
40MP0005248_abnormal_Harderian_gland1.30943583
41MP0002090_abnormal_vision1.27933189
42MP0003787_abnormal_imprinting1.27398660
43MP0002075_abnormal_coat/hair_pigmentati1.26818108
44MP0004147_increased_porphyrin_level1.25749209
45MP0004924_abnormal_behavior1.22483040
46MP0005386_behavior/neurological_phenoty1.22483040
47MP0005645_abnormal_hypothalamus_physiol1.18701940
48MP0002009_preneoplasia1.18074161
49MP0005379_endocrine/exocrine_gland_phen1.17778578
50MP0005197_abnormal_uvea_morphology1.15547342
51MP0008775_abnormal_heart_ventricle1.14108888
52MP0002736_abnormal_nociception_after1.09729004
53MP0002735_abnormal_chemical_nociception1.09593183
54MP0001186_pigmentation_phenotype1.08496309
55MP0004043_abnormal_pH_regulation1.07824216
56MP0003122_maternal_imprinting1.02730263
57MP0010386_abnormal_urinary_bladder1.01947702
58MP0010094_abnormal_chromosome_stability0.99833857
59MP0003121_genomic_imprinting0.99750540
60MP0005377_hearing/vestibular/ear_phenot0.96344069
61MP0003878_abnormal_ear_physiology0.96344069
62MP0006054_spinal_hemorrhage0.94605391
63MP0001529_abnormal_vocalization0.93779193
64MP0009384_cardiac_valve_regurgitation0.92811841
65MP0000427_abnormal_hair_cycle0.92175079
66MP0002751_abnormal_autonomic_nervous0.91870294
67MP0002254_reproductive_system_inflammat0.88905255
68MP0005646_abnormal_pituitary_gland0.86968166
69MP0004142_abnormal_muscle_tone0.86697487
70MP0001293_anophthalmia0.85675758
71MP0000538_abnormal_urinary_bladder0.84983111
72MP0003172_abnormal_lysosome_physiology0.82389394
73MP0006036_abnormal_mitochondrial_physio0.81568387
74MP0004885_abnormal_endolymph0.79099870
75MP0000631_abnormal_neuroendocrine_gland0.78461680
76MP0005195_abnormal_posterior_eye0.77654191
77MP0005187_abnormal_penis_morphology0.76759547
78MP0001905_abnormal_dopamine_level0.74468483
79MP0004133_heterotaxia0.72612281
80MP0002876_abnormal_thyroid_physiology0.69873344
81MP0003111_abnormal_nucleus_morphology0.68605237
82MP0003186_abnormal_redox_activity0.67344293
83MP0000613_abnormal_salivary_gland0.65838528
84MP0009745_abnormal_behavioral_response0.65615320
85MP0003786_premature_aging0.65023393
86MP0002229_neurodegeneration0.64942130
87MP0003755_abnormal_palate_morphology0.63825451
88MP0002928_abnormal_bile_duct0.63794871
89MP0001299_abnormal_eye_distance/0.63762780
90MP0002234_abnormal_pharynx_morphology0.63274972
91MP0010678_abnormal_skin_adnexa0.63020219
92MP0003011_delayed_dark_adaptation0.62969877
93MP0003137_abnormal_impulse_conducting0.62916496
94MP0005391_vision/eye_phenotype0.62857831
95MP0002163_abnormal_gland_morphology0.61345767
96MP0003693_abnormal_embryo_hatching0.57828821
97MP0002160_abnormal_reproductive_system0.57625338
98MP0003950_abnormal_plasma_membrane0.55669070
99MP0001286_abnormal_eye_development0.55486110
100MP0002168_other_aberrant_phenotype0.54593786

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the middle phalanx of the 5th finger (HP:0004219)4.88538412
2Abnormality of the phalanges of the 5th finger (HP:0004213)4.52125455
3Hepatocellular necrosis (HP:0001404)4.41020125
4Hepatic necrosis (HP:0002605)4.17499100
5Symphalangism affecting the phalanges of the hand (HP:0009773)3.35821432
6True hermaphroditism (HP:0010459)3.35060891
7Increased CSF lactate (HP:0002490)3.30076106
8Ocular albinism (HP:0001107)3.29697086
9Progressive macrocephaly (HP:0004481)3.19451366
10Amblyopia (HP:0000646)3.18927580
11Acute necrotizing encephalopathy (HP:0006965)3.17905687
12Aplasia/Hypoplasia of the tibia (HP:0005772)3.10852759
13Mitochondrial inheritance (HP:0001427)3.09927443
14Patchy hypopigmentation of hair (HP:0011365)3.04652897
15Generalized hypopigmentation (HP:0007513)3.00293874
16Congenital stationary night blindness (HP:0007642)3.00015852
17Short tibia (HP:0005736)2.97702552
18Albinism (HP:0001022)2.97036943
19Aplasia/Hypoplasia of the fovea (HP:0008060)2.90646801
20Hypoplasia of the fovea (HP:0007750)2.90646801
21Abnormality of midbrain morphology (HP:0002418)2.87333261
22Molar tooth sign on MRI (HP:0002419)2.87333261
23White forelock (HP:0002211)2.86369351
24Acute encephalopathy (HP:0006846)2.83751852
25Aplasia/Hypoplasia of the macula (HP:0008059)2.80425195
26Iris hypopigmentation (HP:0007730)2.79676163
27Hypothermia (HP:0002045)2.69372393
28Hamartoma of the eye (HP:0010568)2.64473884
29Insidious onset (HP:0003587)2.62736876
30Termporal pattern (HP:0011008)2.62736876
31Aplasia/Hypoplasia affecting the retina (HP:0008061)2.60899831
32Supernumerary nipples (HP:0002558)2.55729441
33Gaze-evoked nystagmus (HP:0000640)2.55569644
34Abnormal mitochondria in muscle tissue (HP:0008316)2.53853384
35Flared iliac wings (HP:0002869)2.51832100
36Pancreatic cysts (HP:0001737)2.43775286
37Pancreatic fibrosis (HP:0100732)2.42313081
38Abnormality of the anterior horn cell (HP:0006802)2.39071768
39Degeneration of anterior horn cells (HP:0002398)2.39071768
40Pheochromocytoma (HP:0002666)2.37548126
41Intestinal atresia (HP:0011100)2.33740598
42CNS demyelination (HP:0007305)2.33508636
43Atonic seizures (HP:0010819)2.33084277
44Clubbing of toes (HP:0100760)2.31522972
45Disproportionate short-trunk short stature (HP:0003521)2.30032956
46Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.29384944
47Degeneration of the lateral corticospinal tracts (HP:0002314)2.29384944
48Hemiparesis (HP:0001269)2.29199423
49Neuroendocrine neoplasm (HP:0100634)2.25834889
50Abnormality of the fovea (HP:0000493)2.24629467
51Abnormality of the astrocytes (HP:0100707)2.22719215
52Astrocytoma (HP:0009592)2.22719215
53Broad nasal tip (HP:0000455)2.21538043
54Anophthalmia (HP:0000528)2.17527115
55Colon cancer (HP:0003003)2.13315798
56Blue irides (HP:0000635)2.12139557
57Respiratory failure (HP:0002878)2.09492048
58Hematochezia (HP:0002573)2.09320639
59Broad-based gait (HP:0002136)2.08731505
60Bifid tongue (HP:0010297)2.05931555
61Absent rod-and cone-mediated responses on ERG (HP:0007688)2.05669721
62Pigmentary retinal degeneration (HP:0001146)2.02300935
63Conjunctival hamartoma (HP:0100780)2.01979586
64Increased hepatocellular lipid droplets (HP:0006565)2.01437234
65Aqueductal stenosis (HP:0002410)1.95895867
66Nephronophthisis (HP:0000090)1.93821862
67Cerebral edema (HP:0002181)1.93414927
68Astigmatism (HP:0000483)1.88385432
69Type II lissencephaly (HP:0007260)1.87283448
70Renal cortical cysts (HP:0000803)1.84445328
71Abnormality of the corticospinal tract (HP:0002492)1.82337444
72Focal seizures (HP:0007359)1.81893791
73Increased serum lactate (HP:0002151)1.79202586
74Glioma (HP:0009733)1.79129275
75Cerebellar dysplasia (HP:0007033)1.77595619
76Hyperventilation (HP:0002883)1.77036570
77Progressive microcephaly (HP:0000253)1.76553197
78Meckel diverticulum (HP:0002245)1.76104325
79Abnormal sex determination (HP:0012244)1.75608373
80Sex reversal (HP:0012245)1.75608373
813-Methylglutaconic aciduria (HP:0003535)1.75539598
82Aplasia/Hypoplasia of the uvula (HP:0010293)1.74949020
83Abnormal rod and cone electroretinograms (HP:0008323)1.74816693
84Abnormality of the ileum (HP:0001549)1.71750094
85Thyroiditis (HP:0100646)1.71347943
86Cutaneous melanoma (HP:0012056)1.70562323
87Genetic anticipation (HP:0003743)1.69653412
88Double outlet right ventricle (HP:0001719)1.68609079
89Congenital malformation of the right heart (HP:0011723)1.68609079
90Symptomatic seizures (HP:0011145)1.68573852
91Preaxial hand polydactyly (HP:0001177)1.65757679
92Neoplasm of the adrenal cortex (HP:0100641)1.65744248
93Transitional cell carcinoma of the bladder (HP:0006740)1.64734337
94Decreased central vision (HP:0007663)1.63473543
95Abnormality of chromosome stability (HP:0003220)1.62809828
96Prolonged QT interval (HP:0001657)1.62608736
97Renal Fanconi syndrome (HP:0001994)1.62087195
98Megaloblastic anemia (HP:0001889)1.61766402
99Lipid accumulation in hepatocytes (HP:0006561)1.61230435
100Thyroid-stimulating hormone excess (HP:0002925)1.61143514

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.60339011
2CASK3.85009957
3WNK33.80928609
4CAMK1D3.47460396
5MKNK23.12344589
6CAMK1G3.06310809
7PDK22.93478235
8BMPR1B2.39232659
9EIF2AK12.38991051
10MKNK12.26616938
11ERBB32.19947774
12EIF2AK32.12352256
13CCNB12.00045588
14WEE11.84499911
15NUAK11.75511000
16NEK11.69475767
17DYRK31.64979780
18PLK31.53358982
19PLK21.53000828
20TRIM281.46158121
21MAP3K41.33796705
22PHKG21.30380842
23PHKG11.30380842
24FGFR21.27556812
25FER1.25625930
26PLK41.24680545
27TNIK1.23696417
28WNK41.17149734
29BRD41.11974535
30ACVR1B1.11752235
31MARK11.10957890
32BRSK11.10015829
33DYRK21.09952927
34INSRR1.06448855
35BRSK21.03249894
36ZAK1.03157042
37PLK10.98010214
38BUB10.97939907
39MAP4K20.97116292
40PAK30.95742843
41STK38L0.93911196
42ADRBK20.91950720
43GRK10.90738603
44SRPK10.89740785
45EPHA40.84863642
46MST40.83177537
47TEC0.82177866
48CSNK1G10.82169247
49PRKAA20.78751187
50PNCK0.78303319
51MAPK130.77821074
52CSNK1A1L0.77773607
53CSNK1G30.74853473
54STK390.74821693
55TGFBR10.73290509
56STK30.72573047
57MAP2K70.66880333
58EIF2AK20.66616624
59PRKCE0.66157421
60CSNK1G20.64642022
61CDC70.63674113
62ADRBK10.61325116
63MAPKAPK50.61036412
64ATM0.60489699
65CAMKK20.59500431
66STK380.58897755
67LIMK10.57459740
68PINK10.57280785
69TSSK60.54871944
70MAPKAPK30.52744624
71MARK30.52402568
72GRK50.50558324
73IRAK30.49386263
74PRKCG0.48366438
75FGFR10.45545149
76ROCK10.45294373
77PTK2B0.44043721
78PRKAA10.42639847
79PRKCI0.42305764
80BRAF0.41108785
81CHEK10.39437803
82TLK10.38608672
83PIK3CA0.38121898
84CAMK2D0.36815840
85ABL20.36077763
86CAMK2A0.35780947
87AKT20.35127218
88MINK10.34496468
89VRK20.34177388
90ERBB20.34107889
91FGFR30.33049305
92CSNK2A10.32526561
93TAOK30.31147034
94PKN10.30712245
95STK160.29146571
96PRKG10.28987490
97ATR0.27732946
98PRKACA0.26691532
99VRK10.25646559
100PRKDC0.25610684

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030604.53989327
2Homologous recombination_Homo sapiens_hsa034404.23465433
3Proteasome_Homo sapiens_hsa030502.73648897
4Basal transcription factors_Homo sapiens_hsa030222.49536637
5Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.46806192
6beta-Alanine metabolism_Homo sapiens_hsa004102.26795201
7Fanconi anemia pathway_Homo sapiens_hsa034602.26208357
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.23885177
9Non-homologous end-joining_Homo sapiens_hsa034502.19954335
10Oxidative phosphorylation_Homo sapiens_hsa001902.16535004
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.13243018
12One carbon pool by folate_Homo sapiens_hsa006702.12888038
13Fatty acid elongation_Homo sapiens_hsa000622.01672764
14Propanoate metabolism_Homo sapiens_hsa006402.01021592
15Butanoate metabolism_Homo sapiens_hsa006501.67956115
16Parkinsons disease_Homo sapiens_hsa050121.67453289
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.61425183
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.51836943
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.50115034
20Tyrosine metabolism_Homo sapiens_hsa003501.42771480
21Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.42474223
22Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.39663295
23RNA polymerase_Homo sapiens_hsa030201.39016889
24Huntingtons disease_Homo sapiens_hsa050161.38868991
25Sulfur metabolism_Homo sapiens_hsa009201.30256746
26Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.25316031
27Nitrogen metabolism_Homo sapiens_hsa009101.22379878
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.20920092
29Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.16597746
30Steroid biosynthesis_Homo sapiens_hsa001001.15633968
31RNA degradation_Homo sapiens_hsa030181.14446917
32Caffeine metabolism_Homo sapiens_hsa002321.11726711
33Nicotine addiction_Homo sapiens_hsa050331.11450770
34Ether lipid metabolism_Homo sapiens_hsa005651.11132083
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.11082920
36Linoleic acid metabolism_Homo sapiens_hsa005911.08492195
37Peroxisome_Homo sapiens_hsa041461.07230919
38Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.04897569
39Taste transduction_Homo sapiens_hsa047421.01341182
40Sphingolipid metabolism_Homo sapiens_hsa006001.00439489
41RNA transport_Homo sapiens_hsa030131.00371924
42TGF-beta signaling pathway_Homo sapiens_hsa043501.00000475
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.97979242
44Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.97595271
45Steroid hormone biosynthesis_Homo sapiens_hsa001400.96442084
46Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.95207625
47Fatty acid metabolism_Homo sapiens_hsa012120.92402662
48Glutathione metabolism_Homo sapiens_hsa004800.92203637
49Cardiac muscle contraction_Homo sapiens_hsa042600.91641032
50Drug metabolism - other enzymes_Homo sapiens_hsa009830.89255756
51N-Glycan biosynthesis_Homo sapiens_hsa005100.86992324
52Purine metabolism_Homo sapiens_hsa002300.86759456
53Arginine and proline metabolism_Homo sapiens_hsa003300.86314982
54Pentose and glucuronate interconversions_Homo sapiens_hsa000400.86042616
55Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.84201993
56Metabolic pathways_Homo sapiens_hsa011000.82977577
57Nucleotide excision repair_Homo sapiens_hsa034200.82017940
58Mineral absorption_Homo sapiens_hsa049780.81703618
59Alzheimers disease_Homo sapiens_hsa050100.81078239
60p53 signaling pathway_Homo sapiens_hsa041150.78105994
61Mismatch repair_Homo sapiens_hsa034300.77441858
62Regulation of autophagy_Homo sapiens_hsa041400.77352993
632-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.77064330
64Tryptophan metabolism_Homo sapiens_hsa003800.76423153
65Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.76410452
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.75777746
67Chemical carcinogenesis_Homo sapiens_hsa052040.75767805
68Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.73803233
69Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.73056452
70Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.70911952
71Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.70739014
72Histidine metabolism_Homo sapiens_hsa003400.69763176
73Vitamin B6 metabolism_Homo sapiens_hsa007500.68487046
74Collecting duct acid secretion_Homo sapiens_hsa049660.67365092
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.66020924
76Fatty acid degradation_Homo sapiens_hsa000710.62319255
77DNA replication_Homo sapiens_hsa030300.60470458
78Primary bile acid biosynthesis_Homo sapiens_hsa001200.59645847
79Maturity onset diabetes of the young_Homo sapiens_hsa049500.59516524
80Folate biosynthesis_Homo sapiens_hsa007900.58343169
81Pyrimidine metabolism_Homo sapiens_hsa002400.55697545
82Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.55675078
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55546200
84Arginine biosynthesis_Homo sapiens_hsa002200.55094184
85Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52875995
86Base excision repair_Homo sapiens_hsa034100.52640058
87Retinol metabolism_Homo sapiens_hsa008300.52082572
88Basal cell carcinoma_Homo sapiens_hsa052170.51332386
89Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.50899340
90Pyruvate metabolism_Homo sapiens_hsa006200.50664801
91Fatty acid biosynthesis_Homo sapiens_hsa000610.49510166
92Selenocompound metabolism_Homo sapiens_hsa004500.48578730
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.46133850
94Fat digestion and absorption_Homo sapiens_hsa049750.45706592
95Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45441442
96ABC transporters_Homo sapiens_hsa020100.43663578
97Phototransduction_Homo sapiens_hsa047440.42617242
98Starch and sucrose metabolism_Homo sapiens_hsa005000.42206513
99Insulin secretion_Homo sapiens_hsa049110.38575031
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38472785

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