ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	piRNA metabolic process (GO:0034587)	6.74718421
2	cytochrome complex assembly (GO:0017004)	5.31352222
3	positive regulation of histone H3-K4 methylation (GO:0051571)	5.15123441
4	rRNA modification (GO:0000154)	5.12173810
5	respiratory chain complex IV assembly (GO:0008535)	4.99018127
6	protein complex biogenesis (GO:0070271)	4.97113130
7	maturation of SSU-rRNA (GO:0030490)	4.83059388
8	rRNA methylation (GO:0031167)	4.82691350
9	GMP metabolic process (GO:0046037)	4.38891836
10	positive regulation of meiosis (GO:0045836)	4.36453723
11	mitochondrial respiratory chain complex assembly (GO:0033108)	4.30040048
12	positive regulation of interleukin-17 production (GO:0032740)	4.17840070
13	positive regulation of natural killer cell differentiation (GO:0032825)	4.17097454
14	regulation of meiosis I (GO:0060631)	4.16677433
15	striated muscle atrophy (GO:0014891)	4.04315545
16	positive regulation of meiotic cell cycle (GO:0051446)	4.01483142
17	negative regulation of phagocytosis (GO:0050765)	3.98581698
18	purine nucleotide salvage (GO:0032261)	3.95188049
19	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.86562026
20	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.86562026
21	NADH dehydrogenase complex assembly (GO:0010257)	3.86562026
22	DNA methylation involved in gamete generation (GO:0043046)	3.83062957
23	gonadal mesoderm development (GO:0007506)	3.74268521
24	indolalkylamine metabolic process (GO:0006586)	3.70908921
25	inositol phosphate dephosphorylation (GO:0046855)	3.69504247
26	phosphorylated carbohydrate dephosphorylation (GO:0046838)	3.69504247
27	skeletal muscle adaptation (GO:0043501)	3.69233296
28	muscle atrophy (GO:0014889)	3.69022965
29	organelle disassembly (GO:1903008)	3.68500635
30	regulation of mitochondrial translation (GO:0070129)	3.64666947
31	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.63433129
32	cellular response to vitamin D (GO:0071305)	3.49987455
33	ribosomal small subunit assembly (GO:0000028)	3.42669201
34	tryptophan metabolic process (GO:0006568)	3.41776705
35	negative regulation of chemokine production (GO:0032682)	3.38524362
36	nucleotide salvage (GO:0043173)	3.36732947
37	positive regulation of histone methylation (GO:0031062)	3.28800122
38	short-chain fatty acid metabolic process (GO:0046459)	3.28199813
39	nucleoside salvage (GO:0043174)	3.25015100
40	thrombin receptor signaling pathway (GO:0070493)	3.24221196
41	TOR signaling (GO:0031929)	3.23568484
42	negative regulation of protein oligomerization (GO:0032460)	3.16444806
43	cellular extravasation (GO:0045123)	3.13451972
44	inositol phosphate catabolic process (GO:0071545)	3.13404658
45	ribosomal large subunit biogenesis (GO:0042273)	3.10925426
46	regulation of B cell receptor signaling pathway (GO:0050855)	3.10541619
47	negative regulation of interleukin-8 production (GO:0032717)	3.10536517
48	negative regulation of multicellular organism growth (GO:0040015)	3.07553248
49	response to pheromone (GO:0019236)	3.04582094
50	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.02867771
51	regulation of natural killer cell differentiation (GO:0032823)	2.95971690
52	import into cell (GO:0098657)	2.94183423
53	interferon-gamma secretion (GO:0072643)	2.91715686
54	mismatch repair (GO:0006298)	2.86999091
55	axoneme assembly (GO:0035082)	2.86936493
56	pseudouridine synthesis (GO:0001522)	2.85983750
57	tryptophan catabolic process (GO:0006569)	2.85563578
58	indole-containing compound catabolic process (GO:0042436)	2.85563578
59	indolalkylamine catabolic process (GO:0046218)	2.85563578
60	cellular response to leptin stimulus (GO:0044320)	2.80599467
61	maternal behavior (GO:0042711)	2.79233863
62	DNA deamination (GO:0045006)	2.78872458
63	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	2.76411726
64	photoreceptor cell maintenance (GO:0045494)	2.75971970
65	mannosylation (GO:0097502)	2.72724396
66	negative regulation of thymocyte apoptotic process (GO:0070244)	2.72704290
67	regulation of cilium movement (GO:0003352)	2.71772581
68	RNA methylation (GO:0001510)	2.70242874
69	positive regulation of granulocyte differentiation (GO:0030854)	2.69765427
70	regulation of histone H3-K4 methylation (GO:0051569)	2.68784536
71	epithelial cilium movement (GO:0003351)	2.67007466
72	ribosomal small subunit biogenesis (GO:0042274)	2.64782010
73	lysine metabolic process (GO:0006553)	2.62995741
74	lysine catabolic process (GO:0006554)	2.62995741
75	respiratory electron transport chain (GO:0022904)	2.58985435
76	natural killer cell differentiation (GO:0001779)	2.56775138
77	electron transport chain (GO:0022900)	2.55979454
78	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.55828085
79	parental behavior (GO:0060746)	2.54760028
80	N-terminal protein amino acid acetylation (GO:0006474)	2.54567232
81	positive regulation by host of viral transcription (GO:0043923)	2.52462033
82	cellular response to interferon-beta (GO:0035458)	2.50626205
83	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.50177659
84	metallo-sulfur cluster assembly (GO:0031163)	2.49011775
85	iron-sulfur cluster assembly (GO:0016226)	2.49011775
86	regulation of RIG-I signaling pathway (GO:0039535)	2.47514987
87	purine-containing compound salvage (GO:0043101)	2.47443810
88	regulation of interleukin-17 production (GO:0032660)	2.44049847
89	regulation of interleukin-8 secretion (GO:2000482)	2.43616368
90	protein import into peroxisome matrix (GO:0016558)	2.43284767
91	protein prenylation (GO:0018342)	2.43238839
92	prenylation (GO:0097354)	2.43238839
93	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.42488678
94	negative regulation of response to food (GO:0032096)	2.42180241
95	negative regulation of appetite (GO:0032099)	2.42180241
96	parturition (GO:0007567)	2.41808945
97	chaperone-mediated protein transport (GO:0072321)	2.40828632
98	motile cilium assembly (GO:0044458)	2.39811255
99	urate metabolic process (GO:0046415)	2.38668765
100	regulation of histone H3-K27 methylation (GO:0061085)	2.38434876

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.95652702
2	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.02305435
3	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	4.00235873
4	IGF1R_20145208_ChIP-Seq_DFB_Human	3.22327821
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.93699553
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.87876658
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.86715671
8	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.84864688
9	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.80672569
10	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.72357137
11	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.69882861
12	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.68744049
13	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.68136610
14	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.49851861
15	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.48229302
16	VDR_22108803_ChIP-Seq_LS180_Human	2.30224706
17	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.21315898
18	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	2.03846758
19	FOXP3_21729870_ChIP-Seq_TREG_Human	2.02799720
20	ER_23166858_ChIP-Seq_MCF-7_Human	1.98190529
21	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.96462312
22	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.96137823
23	VDR_23849224_ChIP-Seq_CD4+_Human	1.95960730
24	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.95160253
25	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.82856756
26	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.81077278
27	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.80094647
28	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.74615910
29	ELK1_19687146_ChIP-ChIP_HELA_Human	1.72765380
30	ZNF274_21170338_ChIP-Seq_K562_Hela	1.71800515
31	DCP1A_22483619_ChIP-Seq_HELA_Human	1.63596763
32	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.63492728
33	GBX2_23144817_ChIP-Seq_PC3_Human	1.62836129
34	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.62479112
35	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.54168269
36	GATA1_22025678_ChIP-Seq_K562_Human	1.54065609
37	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.52324998
38	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.52215361
39	ELF5_23300383_ChIP-Seq_T47D_Human	1.51957008
40	MYB_26560356_Chip-Seq_TH2_Human	1.46465089
41	FUS_26573619_Chip-Seq_HEK293_Human	1.41103531
42	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.40702597
43	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.39651749
44	HTT_18923047_ChIP-ChIP_STHdh_Human	1.37059993
45	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.32328854
46	GATA3_26560356_Chip-Seq_TH2_Human	1.32231934
47	EWS_26573619_Chip-Seq_HEK293_Human	1.32221342
48	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.31661097
49	KDM5A_27292631_Chip-Seq_BREAST_Human	1.29670744
50	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	1.28150668
51	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.27773095
52	TAF15_26573619_Chip-Seq_HEK293_Human	1.27055843
53	EGR1_19374776_ChIP-ChIP_THP-1_Human	1.24490816
54	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.23275375
55	STAT1_20625510_ChIP-Seq_HELA_Human	1.23073941
56	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.22429188
57	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.22422745
58	TP53_22573176_ChIP-Seq_HFKS_Human	1.21451687
59	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.20913114
60	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.18199078
61	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.17430258
62	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.16460058
63	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.13936374
64	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.11238942
65	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.07445104
66	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.07164901
67	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.06983884
68	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.06137001
69	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.04656592
70	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.04519883
71	SPI1_23547873_ChIP-Seq_NB4_Human	1.04386045
72	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.00750148
73	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.00643790
74	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.99367986
75	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.98813453
76	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.98101284
77	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.98101284
78	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	0.98057887
79	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.97785384
80	IRF8_21731497_ChIP-ChIP_J774_Mouse	0.93953930
81	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	0.92421451
82	SCL_19346495_ChIP-Seq_HPC-7_Human	0.92358240
83	NANOG_19829295_ChIP-Seq_ESCs_Human	0.92142761
84	SOX2_19829295_ChIP-Seq_ESCs_Human	0.92142761
85	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.90554593
86	AR_20517297_ChIP-Seq_VCAP_Human	0.89998504
87	CBP_20019798_ChIP-Seq_JUKART_Human	0.89631714
88	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.89631714
89	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	0.86773298
90	TTF2_22483619_ChIP-Seq_HELA_Human	0.86118975
91	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	0.84993602
92	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.84495815
93	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	0.83051800
94	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.82783870
95	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.82279238
96	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.81871057
97	CDX2_22108803_ChIP-Seq_LS180_Human	0.80727951
98	P53_21459846_ChIP-Seq_SAOS-2_Human	0.80695556
99	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.80391796
100	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.79682820

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003806_abnormal_nucleotide_metabolis	3.33425105
2	MP0009379_abnormal_foot_pigmentation	3.24442309
3	MP0001986_abnormal_taste_sensitivity	2.78448164
4	MP0003252_abnormal_bile_duct	2.69780416
5	MP0002396_abnormal_hematopoietic_system	2.58927502
6	MP0008057_abnormal_DNA_replication	2.50037320
7	MP0010234_abnormal_vibrissa_follicle	2.44323379
8	MP0006035_abnormal_mitochondrial_morpho	2.25784186
9	MP0002837_dystrophic_cardiac_calcinosis	2.20713233
10	MP0000015_abnormal_ear_pigmentation	2.20370347
11	MP0002822_catalepsy	2.19133895
12	MP0005075_abnormal_melanosome_morpholog	2.17162571
13	MP0004885_abnormal_endolymph	2.11319164
14	MP0002876_abnormal_thyroid_physiology	2.07830351
15	MP0006036_abnormal_mitochondrial_physio	2.07628146
16	MP0008058_abnormal_DNA_repair	2.05914355
17	MP0005409_darkened_coat_color	1.93727747
18	MP0005645_abnormal_hypothalamus_physiol	1.92968987
19	MP0003718_maternal_effect	1.87022205
20	MP0005464_abnormal_platelet_physiology	1.86326492
21	MP0001968_abnormal_touch/_nociception	1.81669011
22	MP0004782_abnormal_surfactant_physiolog	1.79129272
23	MP0001764_abnormal_homeostasis	1.69412258
24	MP0003787_abnormal_imprinting	1.68116649
25	MP0002006_tumorigenesis	1.59901858
26	MP0005174_abnormal_tail_pigmentation	1.57953593
27	MP0010368_abnormal_lymphatic_system	1.56184816
28	MP0003075_altered_response_to	1.55692028
29	MP0001984_abnormal_olfaction	1.53882872
30	MP0010678_abnormal_skin_adnexa	1.51419428
31	MP0001661_extended_life_span	1.51379550
32	MP0005451_abnormal_body_composition	1.51317005
33	MP0002166_altered_tumor_susceptibility	1.49067584
34	MP0004147_increased_porphyrin_level	1.45049486
35	MP0001188_hyperpigmentation	1.41768964
36	MP0001905_abnormal_dopamine_level	1.41143415
37	MP0002254_reproductive_system_inflammat	1.40739644
38	MP0000685_abnormal_immune_system	1.38751920
39	MP0009780_abnormal_chondrocyte_physiolo	1.34423723
40	MP0004215_abnormal_myocardial_fiber	1.33766154
41	MP0008872_abnormal_physiological_respon	1.33495802
42	MP0004084_abnormal_cardiac_muscle	1.33010497
43	MP0005220_abnormal_exocrine_pancreas	1.31763436
44	MP0005647_abnormal_sex_gland	1.31445464
45	MP0010094_abnormal_chromosome_stability	1.29842110
46	MP0008775_abnormal_heart_ventricle	1.29823823
47	MP0002733_abnormal_thermal_nociception	1.27891841
48	MP0005551_abnormal_eye_electrophysiolog	1.24493786
49	MP0004036_abnormal_muscle_relaxation	1.23939423
50	MP0003183_abnormal_peptide_metabolism	1.17443764
51	MP0003646_muscle_fatigue	1.17187806
52	MP0000383_abnormal_hair_follicle	1.14818772
53	MP0003011_delayed_dark_adaptation	1.14651444
54	MP0003283_abnormal_digestive_organ	1.13656747
55	MP0005365_abnormal_bile_salt	1.12062866
56	MP0001835_abnormal_antigen_presentation	1.10013944
57	MP0005423_abnormal_somatic_nervous	1.08296064
58	MP0005085_abnormal_gallbladder_physiolo	1.07695396
59	MP0005165_increased_susceptibility_to	1.06017816
60	MP0000358_abnormal_cell_content/	1.05753170
61	MP0008007_abnormal_cellular_replicative	1.05480821
62	MP0001970_abnormal_pain_threshold	1.04420954
63	MP0001929_abnormal_gametogenesis	1.03755703
64	MP0009785_altered_susceptibility_to	1.01613649
65	MP0008995_early_reproductive_senescence	1.01475695
66	MP0002736_abnormal_nociception_after	1.01020284
67	MP0001944_abnormal_pancreas_morphology	0.96951658
68	MP0010386_abnormal_urinary_bladder	0.96406054
69	MP0002928_abnormal_bile_duct	0.95931200
70	MP0009764_decreased_sensitivity_to	0.94009799
71	MP0002095_abnormal_skin_pigmentation	0.92821809
72	MP0005266_abnormal_metabolism	0.90939544
73	MP0005397_hematopoietic_system_phenotyp	0.90507428
74	MP0001545_abnormal_hematopoietic_system	0.90507428
75	MP0000653_abnormal_sex_gland	0.90243165
76	MP0000372_irregular_coat_pigmentation	0.89859260
77	MP0002160_abnormal_reproductive_system	0.89399800
78	MP0000230_abnormal_systemic_arterial	0.87444163
79	MP0010329_abnormal_lipoprotein_level	0.87202425
80	MP0001765_abnormal_ion_homeostasis	0.86475552
81	MP0001819_abnormal_immune_cell	0.86375870
82	MP0000681_abnormal_thyroid_gland	0.86224966
83	MP0002693_abnormal_pancreas_physiology	0.85911584
84	MP0003121_genomic_imprinting	0.85067113
85	MP0002272_abnormal_nervous_system	0.84621651
86	MP0001800_abnormal_humoral_immune	0.84227032
87	MP0002229_neurodegeneration	0.83903409
88	MP0002019_abnormal_tumor_incidence	0.83245210
89	MP0002723_abnormal_immune_serum	0.81869008
90	MP0002148_abnormal_hypersensitivity_rea	0.81716053
91	MP0002420_abnormal_adaptive_immunity	0.80333392
92	MP0003638_abnormal_response/metabolism_	0.79885057
93	MP0005389_reproductive_system_phenotype	0.79875843
94	MP0001486_abnormal_startle_reflex	0.79684142
95	MP0001145_abnormal_male_reproductive	0.79646163
96	MP0004043_abnormal_pH_regulation	0.78480995
97	MP0005646_abnormal_pituitary_gland	0.78431574
98	MP0005386_behavior/neurological_phenoty	0.78318401
99	MP0004924_abnormal_behavior	0.78318401
100	MP0003436_decreased_susceptibility_to	0.77010797

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hepatocellular necrosis (HP:0001404)	4.40154297
2	Hepatic necrosis (HP:0002605)	4.12081862
3	Tubulointerstitial nephritis (HP:0001970)	4.09051731
4	Ragged-red muscle fibers (HP:0003200)	3.94631652
5	Elevated erythrocyte sedimentation rate (HP:0003565)	3.86637460
6	Petechiae (HP:0000967)	3.75762057
7	Thrombocytosis (HP:0001894)	3.69977411
8	B lymphocytopenia (HP:0010976)	3.55907144
9	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.54724264
10	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.54724264
11	Abnormality of B cell number (HP:0010975)	3.42627502
12	Abnormal number of erythroid precursors (HP:0012131)	3.20632080
13	Abnormality of the prostate (HP:0008775)	3.18142591
14	Mitochondrial inheritance (HP:0001427)	3.11230264
15	Hypoplasia of the thymus (HP:0000778)	3.09722379
16	Microvesicular hepatic steatosis (HP:0001414)	3.06153373
17	Abnormality of cells of the erythroid lineage (HP:0012130)	3.04772387
18	Acute lymphatic leukemia (HP:0006721)	3.01222644
19	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.84106038
20	Reticulocytopenia (HP:0001896)	2.81024885
21	Slow saccadic eye movements (HP:0000514)	2.80610004
22	Increased CSF lactate (HP:0002490)	2.77744341
23	Type I transferrin isoform profile (HP:0003642)	2.73000769
24	Bile duct proliferation (HP:0001408)	2.71008466
25	Abnormal biliary tract physiology (HP:0012439)	2.71008466
26	Papilledema (HP:0001085)	2.69460181
27	Abnormal mitochondria in muscle tissue (HP:0008316)	2.67317290
28	Abnormality of macular pigmentation (HP:0008002)	2.63285384
29	Chromsome breakage (HP:0040012)	2.60870832
30	Central scotoma (HP:0000603)	2.55087475
31	Increased serum lactate (HP:0002151)	2.52424087
32	Lactic acidosis (HP:0003128)	2.46193158
33	Molar tooth sign on MRI (HP:0002419)	2.44457082
34	Abnormality of midbrain morphology (HP:0002418)	2.44457082
35	Constricted visual fields (HP:0001133)	2.44191214
36	Absent thumb (HP:0009777)	2.43060358
37	Pancreatic fibrosis (HP:0100732)	2.42243217
38	Abnormal spermatogenesis (HP:0008669)	2.42103891
39	Azoospermia (HP:0000027)	2.41302782
40	Progressive macrocephaly (HP:0004481)	2.38269022
41	Acute necrotizing encephalopathy (HP:0006965)	2.37363901
42	Neutropenia (HP:0001875)	2.31112673
43	Increased serum pyruvate (HP:0003542)	2.27873838
44	Hypoglycemic seizures (HP:0002173)	2.27811508
45	Abnormality of chromosome stability (HP:0003220)	2.25728634
46	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.22741572
47	Nephronophthisis (HP:0000090)	2.21051126
48	Absent/shortened dynein arms (HP:0200106)	2.20435104
49	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.20435104
50	Panhypogammaglobulinemia (HP:0003139)	2.15743520
51	Cerebral edema (HP:0002181)	2.14792762
52	Medial flaring of the eyebrow (HP:0010747)	2.14263897
53	Acute encephalopathy (HP:0006846)	2.11376083
54	Purpura (HP:0000979)	2.10135912
55	Tubulointerstitial abnormality (HP:0001969)	2.09379587
56	Clubbing of toes (HP:0100760)	2.08935719
57	IgM deficiency (HP:0002850)	2.08477343
58	Prostate neoplasm (HP:0100787)	2.06783335
59	Respiratory difficulties (HP:0002880)	2.05719920
60	Acute myeloid leukemia (HP:0004808)	2.05360289
61	Progressive muscle weakness (HP:0003323)	2.03871203
62	Prolonged bleeding time (HP:0003010)	2.02454925
63	Cone-rod dystrophy (HP:0000548)	2.02412545
64	Abnormality of lateral ventricle (HP:0030047)	2.01167267
65	Hypoglycemic coma (HP:0001325)	2.00406743
66	Respiratory failure (HP:0002878)	2.00036444
67	Increased muscle lipid content (HP:0009058)	1.97788420
68	Duplicated collecting system (HP:0000081)	1.97020446
69	Increased intramyocellular lipid droplets (HP:0012240)	1.95696353
70	Abnormality of DNA repair (HP:0003254)	1.95215418
71	Hemiparesis (HP:0001269)	1.94480724
72	Abnormal protein glycosylation (HP:0012346)	1.93825486
73	Abnormal glycosylation (HP:0012345)	1.93825486
74	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.93825486
75	Abnormal protein N-linked glycosylation (HP:0012347)	1.93825486
76	Exercise intolerance (HP:0003546)	1.93074134
77	Gonadotropin excess (HP:0000837)	1.92355867
78	Opisthotonus (HP:0002179)	1.92259199
79	Dicarboxylic aciduria (HP:0003215)	1.91190623
80	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.91190623
81	Emotional lability (HP:0000712)	1.89880449
82	Autoimmune hemolytic anemia (HP:0001890)	1.86785144
83	Agammaglobulinemia (HP:0004432)	1.85665655
84	Abnormality of the renal collecting system (HP:0004742)	1.85477718
85	Ketosis (HP:0001946)	1.84723896
86	Abnormality of the renal cortex (HP:0011035)	1.83311319
87	Nephrogenic diabetes insipidus (HP:0009806)	1.83015551
88	Abnormality of the renal medulla (HP:0100957)	1.81795507
89	Hip dysplasia (HP:0001385)	1.81506645
90	Polydipsia (HP:0001959)	1.79952614
91	Abnormal drinking behavior (HP:0030082)	1.79952614
92	Abnormality of glycolysis (HP:0004366)	1.79714192
93	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.78749488
94	Anhidrosis (HP:0000970)	1.78315165
95	Hyperglycinemia (HP:0002154)	1.78245681
96	Neoplasm of head and neck (HP:0012288)	1.77700645
97	Esophageal neoplasm (HP:0100751)	1.77700645
98	Abnormal sex determination (HP:0012244)	1.76955822
99	Sex reversal (HP:0012245)	1.76955822
100	Recurrent cutaneous fungal infections (HP:0011370)	1.76454099

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAF1	5.74538975
2	FRK	4.28307671
3	RIPK4	4.11445422
4	NUAK1	3.52036533
5	VRK2	3.27635782
6	TAOK3	3.12249232
7	TRPM7	2.69144084
8	KIT	2.61018696
9	BCKDK	2.57100899
10	MAP4K2	2.45920966
11	BMPR2	2.37601938
12	PIK3CG	2.12154293
13	FLT3	1.83457608
14	EIF2AK1	1.76517179
15	ERBB3	1.69516078
16	STK24	1.69326541
17	DAPK2	1.67270262
18	VRK1	1.63820259
19	STK38	1.55811116
20	WNK4	1.48094624
21	GRK1	1.42410809
22	STK39	1.38599560
23	MKNK2	1.33054984
24	TEC	1.23714090
25	DAPK1	1.23434511
26	MAP3K13	1.23403208
27	PHKG1	1.23243554
28	PHKG2	1.23243554
29	TRIM28	1.16865586
30	FGFR2	1.13947246
31	CSF1R	1.12616659
32	PDK2	1.11946262
33	PRKCQ	1.05673952
34	PINK1	1.05450682
35	BRSK2	1.02250202
36	STK16	1.01154179
37	PASK	0.99864345
38	INSRR	0.93497286
39	TNK2	0.93493375
40	STK38L	0.92003958
41	ADRBK2	0.91035697
42	EIF2AK3	0.90479739
43	MAP3K2	0.86781417
44	NME2	0.78649088
45	LATS1	0.77897000
46	PIK3CA	0.75726676
47	MATK	0.75310812
48	ATR	0.75137082
49	NEK9	0.74799493
50	PTK2B	0.74347610
51	MST4	0.73416952
52	PLK3	0.72131356
53	MAP3K14	0.64184055
54	KSR2	0.64001929
55	ZAK	0.61971344
56	ARAF	0.61801996
57	MKNK1	0.59116897
58	PRKD2	0.58785628
59	CAMK1G	0.58057044
60	ITK	0.55914558
61	CDK4	0.54554340
62	IKBKB	0.54350122
63	WNK1	0.51948874
64	PAK3	0.51037551
65	TAOK1	0.48779178
66	RPS6KB2	0.46866691
67	CDC7	0.46597633
68	CAMKK2	0.46213384
69	CAMK1D	0.45910504
70	MAP3K12	0.44546955
71	ILK	0.44519691
72	PLK1	0.44472506
73	ACVR1B	0.44190030
74	SYK	0.41387535
75	FES	0.39746079
76	ABL2	0.39361573
77	WNK3	0.37092803
78	HCK	0.36486804
79	CCNB1	0.34661884
80	PRKAA2	0.34245476
81	BTK	0.34230939
82	TXK	0.34085533
83	CDK19	0.33496731
84	CSNK2A1	0.33106649
85	DAPK3	0.32735106
86	STK3	0.32276411
87	JAK3	0.32047398
88	PDK1	0.31874890
89	LYN	0.31765172
90	TBK1	0.30901966
91	TLK1	0.30540477
92	PRKG1	0.30432815
93	RPS6KB1	0.29110601
94	CSNK2A2	0.28528223
95	PRKCH	0.27796508
96	PDPK1	0.26720746
97	PRKCG	0.26587012
98	TTK	0.26349304
99	CAMK1	0.25742085
100	NME1	0.25619940

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Homologous recombination_Homo sapiens_hsa03440	3.80409829
2	RNA polymerase_Homo sapiens_hsa03020	3.24854575
3	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	2.72742413
4	Ribosome_Homo sapiens_hsa03010	2.71894356
5	Mismatch repair_Homo sapiens_hsa03430	2.68149719
6	Fatty acid elongation_Homo sapiens_hsa00062	2.54114091
7	Oxidative phosphorylation_Homo sapiens_hsa00190	2.47957556
8	Proteasome_Homo sapiens_hsa03050	2.21490222
9	One carbon pool by folate_Homo sapiens_hsa00670	2.04308983
10	Fanconi anemia pathway_Homo sapiens_hsa03460	2.00024964
11	Linoleic acid metabolism_Homo sapiens_hsa00591	1.95439246
12	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.94227912
13	DNA replication_Homo sapiens_hsa03030	1.93406303
14	Basal transcription factors_Homo sapiens_hsa03022	1.92496931
15	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.85116226
16	Parkinsons disease_Homo sapiens_hsa05012	1.79376993
17	Base excision repair_Homo sapiens_hsa03410	1.73281932
18	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.71339134
19	Purine metabolism_Homo sapiens_hsa00230	1.68123553
20	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.67676535
21	Tryptophan metabolism_Homo sapiens_hsa00380	1.63021968
22	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.59761662
23	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.55792082
24	Pyrimidine metabolism_Homo sapiens_hsa00240	1.53190075
25	Other glycan degradation_Homo sapiens_hsa00511	1.52559470
26	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.47424176
27	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.46683125
28	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.35407627
29	Fatty acid metabolism_Homo sapiens_hsa01212	1.33684961
30	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.33266956
31	Alzheimers disease_Homo sapiens_hsa05010	1.28725748
32	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.28470992
33	Folate biosynthesis_Homo sapiens_hsa00790	1.25891629
34	Primary immunodeficiency_Homo sapiens_hsa05340	1.19129487
35	ABC transporters_Homo sapiens_hsa02010	1.18947885
36	Huntingtons disease_Homo sapiens_hsa05016	1.18191353
37	Non-homologous end-joining_Homo sapiens_hsa03450	1.16963130
38	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.15848564
39	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.15730899
40	Propanoate metabolism_Homo sapiens_hsa00640	1.14419206
41	RNA degradation_Homo sapiens_hsa03018	1.14332918
42	Nucleotide excision repair_Homo sapiens_hsa03420	1.06182959
43	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.04061798
44	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.03414214
45	mTOR signaling pathway_Homo sapiens_hsa04150	1.00828405
46	Insulin secretion_Homo sapiens_hsa04911	1.00649546
47	Peroxisome_Homo sapiens_hsa04146	1.00338573
48	African trypanosomiasis_Homo sapiens_hsa05143	0.92761643
49	Ether lipid metabolism_Homo sapiens_hsa00565	0.91310877
50	RNA transport_Homo sapiens_hsa03013	0.88642435
51	Selenocompound metabolism_Homo sapiens_hsa00450	0.88399192
52	Asthma_Homo sapiens_hsa05310	0.84810512
53	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.81593259
54	Taste transduction_Homo sapiens_hsa04742	0.79682638
55	Protein export_Homo sapiens_hsa03060	0.79586928
56	Calcium signaling pathway_Homo sapiens_hsa04020	0.79015386
57	Pancreatic secretion_Homo sapiens_hsa04972	0.77502632
58	Olfactory transduction_Homo sapiens_hsa04740	0.77385601
59	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.77348184
60	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.72855180
61	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.70291043
62	Metabolic pathways_Homo sapiens_hsa01100	0.69958123
63	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.69543110
64	Regulation of autophagy_Homo sapiens_hsa04140	0.69245905
65	Glucagon signaling pathway_Homo sapiens_hsa04922	0.66498084
66	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.65835744
67	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.65283819
68	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.59182825
69	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.59042492
70	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.58615168
71	Cardiac muscle contraction_Homo sapiens_hsa04260	0.55912079
72	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.54630284
73	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.53457185
74	Serotonergic synapse_Homo sapiens_hsa04726	0.52228814
75	Antigen processing and presentation_Homo sapiens_hsa04612	0.52133003
76	Type I diabetes mellitus_Homo sapiens_hsa04940	0.51247087
77	Platelet activation_Homo sapiens_hsa04611	0.50650745
78	Salivary secretion_Homo sapiens_hsa04970	0.50421751
79	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.50274007
80	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.46674907
81	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.44719605
82	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.43456412
83	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.41372046
84	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.40377595
85	Long-term depression_Homo sapiens_hsa04730	0.40222783
86	Pyruvate metabolism_Homo sapiens_hsa00620	0.39046095
87	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.37416020
88	Retinol metabolism_Homo sapiens_hsa00830	0.36073686
89	Chemical carcinogenesis_Homo sapiens_hsa05204	0.35359693
90	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.34796852
91	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.34452496
92	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.32233091
93	Butanoate metabolism_Homo sapiens_hsa00650	0.30623202
94	Allograft rejection_Homo sapiens_hsa05330	0.30512531
95	Acute myeloid leukemia_Homo sapiens_hsa05221	0.30331376
96	Choline metabolism in cancer_Homo sapiens_hsa05231	0.29200638
97	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.28936016
98	Herpes simplex infection_Homo sapiens_hsa05168	0.28085480
99	Spliceosome_Homo sapiens_hsa03040	0.26827610
100	Nitrogen metabolism_Homo sapiens_hsa00910	0.26417431

CYCSP34

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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