CYCSP35

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.74829765
2histone-serine phosphorylation (GO:0035404)5.14075365
3water-soluble vitamin biosynthetic process (GO:0042364)5.11265451
4spliceosomal complex assembly (GO:0000245)4.99616456
5sulfation (GO:0051923)4.95615771
6chaperone-mediated protein transport (GO:0072321)4.83140290
7regulation of posttranscriptional gene silencing (GO:0060147)4.81329344
8regulation of gene silencing by miRNA (GO:0060964)4.81329344
9regulation of gene silencing by RNA (GO:0060966)4.81329344
10regulation of DNA endoreduplication (GO:0032875)4.74137806
11ATP synthesis coupled proton transport (GO:0015986)4.68719775
12energy coupled proton transport, down electrochemical gradient (GO:0015985)4.68719775
13mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.58580310
14respiratory electron transport chain (GO:0022904)4.34680365
15histone H2B ubiquitination (GO:0033523)4.33766482
16regulation of phospholipid biosynthetic process (GO:0071071)4.29533290
17electron transport chain (GO:0022900)4.27790569
18establishment of protein localization to mitochondrial membrane (GO:0090151)4.22181041
19spinal cord motor neuron differentiation (GO:0021522)4.08646646
20histone H3-K4 trimethylation (GO:0080182)4.08600019
21chromatin remodeling at centromere (GO:0031055)4.07825898
22regulation of branching involved in salivary gland morphogenesis (GO:0060693)4.07650994
23termination of RNA polymerase III transcription (GO:0006386)4.06949486
24transcription elongation from RNA polymerase III promoter (GO:0006385)4.06949486
25positive regulation of histone H3-K4 methylation (GO:0051571)3.95265975
26spliceosomal snRNP assembly (GO:0000387)3.94462359
27cellular response to ATP (GO:0071318)3.92491801
28regulation of glomerulus development (GO:0090192)3.86347809
29regulation of cell maturation (GO:1903429)3.85607927
30CENP-A containing nucleosome assembly (GO:0034080)3.79784408
31regulation of spindle checkpoint (GO:0090231)3.78822862
32otic vesicle formation (GO:0030916)3.70364849
33N-acetylglucosamine metabolic process (GO:0006044)3.67126141
34centrosome localization (GO:0051642)3.65301121
35positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)3.60174758
36behavioral response to nicotine (GO:0035095)3.59564484
37interleukin-6-mediated signaling pathway (GO:0070102)3.58240997
38cell fate commitment involved in formation of primary germ layer (GO:0060795)3.58197526
39exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.52198984
40respiratory chain complex IV assembly (GO:0008535)3.50295044
41inner ear receptor cell development (GO:0060119)3.47204326
42protein localization to microtubule cytoskeleton (GO:0072698)3.43671409
43protein neddylation (GO:0045116)3.43509739
44nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.42361174
45histone exchange (GO:0043486)3.40071967
46regulation of cell proliferation involved in kidney development (GO:1901722)3.37789316
47dorsal/ventral axis specification (GO:0009950)3.37054626
48epithelial cell fate commitment (GO:0072148)3.30808301
49cell proliferation in forebrain (GO:0021846)3.30805617
50regulation of acrosome reaction (GO:0060046)3.27751229
51pre-miRNA processing (GO:0031054)3.21180178
52peristalsis (GO:0030432)3.20464970
53neuron fate determination (GO:0048664)3.19987519
54cytochrome complex assembly (GO:0017004)3.11590645
55negative regulation of transcription regulatory region DNA binding (GO:2000678)3.10116380
56pseudouridine synthesis (GO:0001522)3.10084627
57mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.04539084
58mitochondrial respiratory chain complex I assembly (GO:0032981)3.04539084
59NADH dehydrogenase complex assembly (GO:0010257)3.04539084
60protein complex biogenesis (GO:0070271)3.01730945
61regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.01668614
62regulation of mitotic spindle checkpoint (GO:1903504)3.01668614
63positive regulation of oligodendrocyte differentiation (GO:0048714)2.99007975
64ATP biosynthetic process (GO:0006754)2.97800584
65mitochondrial respiratory chain complex assembly (GO:0033108)2.92833280
66ribosomal small subunit biogenesis (GO:0042274)2.91286006
67regulation of spindle organization (GO:0090224)2.90223094
68deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.90083897
69viral transcription (GO:0019083)2.89428441
70ribosomal small subunit assembly (GO:0000028)2.87033756
71regulation of mitochondrial translation (GO:0070129)2.86848021
72hydrogen ion transmembrane transport (GO:1902600)2.80671315
73positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.78759580
74positive regulation of cell cycle G2/M phase transition (GO:1902751)2.78759580
75negative regulation of cardiac muscle tissue development (GO:0055026)2.78374125
76regulation of helicase activity (GO:0051095)2.78140197
77protein localization to cytoskeleton (GO:0044380)2.77473650
78DNA replication-independent nucleosome organization (GO:0034724)2.77384073
79DNA replication-independent nucleosome assembly (GO:0006336)2.77384073
80opsonization (GO:0008228)2.76462088
81termination of RNA polymerase II transcription (GO:0006369)2.75627407
82artery development (GO:0060840)2.74510125
83regulation of chromatin binding (GO:0035561)2.73887827
84lateral sprouting from an epithelium (GO:0060601)2.73443699
85pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.73023329
86DNA-templated transcription, termination (GO:0006353)2.72493299
87positive regulation of fatty acid beta-oxidation (GO:0032000)2.71977097
88protein targeting to mitochondrion (GO:0006626)2.71581926
89response to UV-C (GO:0010225)2.70475351
90negative regulation of telomerase activity (GO:0051974)2.70447415
91female gonad development (GO:0008585)2.69619334
92regulation of G2/M transition of mitotic cell cycle (GO:0010389)2.68376554
93negative regulation of DNA-dependent DNA replication (GO:2000104)2.66144100
94proteasome assembly (GO:0043248)2.65714397
95rRNA modification (GO:0000154)2.64348003
96presynaptic membrane assembly (GO:0097105)2.62519850
97positive regulation of metanephros development (GO:0072216)2.61773579
98translational termination (GO:0006415)2.61025047
99regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.60804475
100pituitary gland development (GO:0021983)2.60004188

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYCN_21190229_ChIP-Seq_SHEP-21N_Human4.18529818
2E2F7_22180533_ChIP-Seq_HELA_Human4.07103951
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.94116596
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.53383022
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.50535080
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.45460357
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.98951264
8CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.65915147
9DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.65736911
10POU5F1_16153702_ChIP-ChIP_HESCs_Human2.65188196
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.61103762
12EZH2_22144423_ChIP-Seq_EOC_Human2.49404155
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.41773119
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.41676545
15NANOG_16153702_ChIP-ChIP_HESCs_Human2.34922891
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.34225178
17ELK1_19687146_ChIP-ChIP_HELA_Human2.09465624
18FOXM1_23109430_ChIP-Seq_U2OS_Human2.07604161
19EWS_26573619_Chip-Seq_HEK293_Human2.04950141
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.01142327
21SOX2_18555785_ChIP-Seq_MESCs_Mouse1.94577949
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.93008196
23MYC_18940864_ChIP-ChIP_HL60_Human1.91748539
24SOX2_16153702_ChIP-ChIP_HESCs_Human1.91359611
25FUS_26573619_Chip-Seq_HEK293_Human1.90788985
26STAT6_21828071_ChIP-Seq_BEAS2B_Human1.87107213
27PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.82358293
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.79935968
29MYC_19030024_ChIP-ChIP_MESCs_Mouse1.79228484
30JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.78060703
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.77119619
32YY1_21170310_ChIP-Seq_MESCs_Mouse1.74712801
33CREB1_15753290_ChIP-ChIP_HEK293T_Human1.74160364
34TCF3_18692474_ChIP-Seq_MEFs_Mouse1.72464280
35VDR_22108803_ChIP-Seq_LS180_Human1.71162953
36MYC_19079543_ChIP-ChIP_MESCs_Mouse1.70975226
37BMI1_23680149_ChIP-Seq_NPCS_Mouse1.70859257
38KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.55582601
39KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.55582601
40KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.55582601
41SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.52647123
42PADI4_21655091_ChIP-ChIP_MCF-7_Human1.49766191
43GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.47464797
44TCF3_18692474_ChIP-Seq_MESCs_Mouse1.46133159
45FOXP3_21729870_ChIP-Seq_TREG_Human1.39953991
46NANOG_18555785_ChIP-Seq_MESCs_Mouse1.39128844
47MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.35097488
48TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.33078076
49TP63_19390658_ChIP-ChIP_HaCaT_Human1.31629730
50NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.31375480
51TTF2_22483619_ChIP-Seq_HELA_Human1.30053578
52GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.28987339
53E2F1_21310950_ChIP-Seq_MCF-7_Human1.27284658
54NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.26502041
55P53_22127205_ChIP-Seq_FIBROBLAST_Human1.25269037
56YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.25197830
57POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.24378359
58ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.21198618
59RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17572137
60MYC_18358816_ChIP-ChIP_MESCs_Mouse1.15564095
61POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.14954449
62P300_19829295_ChIP-Seq_ESCs_Human1.13967369
63ZNF274_21170338_ChIP-Seq_K562_Hela1.13806152
64AUTS2_25519132_ChIP-Seq_293T-REX_Human1.13557076
65POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.09115245
66PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08253042
67HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.06994219
68HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.06366022
69THAP11_20581084_ChIP-Seq_MESCs_Mouse1.05648673
70MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05564577
71CBP_20019798_ChIP-Seq_JUKART_Human1.03942902
72IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.03942902
73NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.02452004
74VDR_23849224_ChIP-Seq_CD4+_Human1.02327741
75TAF15_26573619_Chip-Seq_HEK293_Human1.01796682
76SOX2_18692474_ChIP-Seq_MEFs_Mouse1.00298919
77FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.99342887
78ESR1_15608294_ChIP-ChIP_MCF-7_Human0.98255732
79BCAT_22108803_ChIP-Seq_LS180_Human0.97239130
80LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95980886
81EED_16625203_ChIP-ChIP_MESCs_Mouse0.94006204
82IRF1_19129219_ChIP-ChIP_H3396_Human0.92983754
83TOP2B_26459242_ChIP-Seq_MCF-7_Human0.91606359
84NANOG_18692474_ChIP-Seq_MEFs_Mouse0.91145646
85TDRD3_21172665_ChIP-Seq_MCF-7_Human0.90964582
86ELK1_22589737_ChIP-Seq_MCF10A_Human0.90487062
87CTBP1_25329375_ChIP-Seq_LNCAP_Human0.89153049
88ZFP57_27257070_Chip-Seq_ESCs_Mouse0.88836099
89XRN2_22483619_ChIP-Seq_HELA_Human0.88610622
90SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.87589381
91EZH2_27304074_Chip-Seq_ESCs_Mouse0.86038773
92NANOG_18692474_ChIP-Seq_MESCs_Mouse0.85730870
93SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.85422842
94SOX2_18692474_ChIP-Seq_MESCs_Mouse0.83582637
95RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.83477258
96SRF_21415370_ChIP-Seq_HL-1_Mouse0.81475420
97CTBP2_25329375_ChIP-Seq_LNCAP_Human0.79462532
98JUN_21703547_ChIP-Seq_K562_Human0.78953598
99E2F1_18555785_ChIP-Seq_MESCs_Mouse0.78390822
100TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.78215345

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.23000529
2MP0003693_abnormal_embryo_hatching4.16295487
3MP0003941_abnormal_skin_development4.02563845
4MP0009379_abnormal_foot_pigmentation3.53372688
5MP0008877_abnormal_DNA_methylation3.08826555
6MP0008057_abnormal_DNA_replication2.97942715
7MP0004134_abnormal_chest_morphology2.66856047
8MP0003195_calcinosis2.39657988
9MP0003787_abnormal_imprinting2.30495777
10MP0000049_abnormal_middle_ear2.20134057
11MP0002277_abnormal_respiratory_mucosa2.20071472
12MP0002735_abnormal_chemical_nociception2.13428573
13MP0001485_abnormal_pinna_reflex2.10780518
14MP0009780_abnormal_chondrocyte_physiolo2.04968544
15MP0006072_abnormal_retinal_apoptosis2.01243296
16MP0010094_abnormal_chromosome_stability1.97912778
17MP0001188_hyperpigmentation1.83099709
18MP0003111_abnormal_nucleus_morphology1.74620152
19MP0003122_maternal_imprinting1.69857872
20MP0003136_yellow_coat_color1.69524601
21MP0009250_abnormal_appendicular_skeleto1.69397869
22MP0003121_genomic_imprinting1.64395728
23MP0004885_abnormal_endolymph1.56883599
24MP0001293_anophthalmia1.54631430
25MP0004133_heterotaxia1.53742464
26MP0000631_abnormal_neuroendocrine_gland1.53523778
27MP0003077_abnormal_cell_cycle1.52597178
28MP0001968_abnormal_touch/_nociception1.49259460
29MP0003938_abnormal_ear_development1.42049246
30MP0002160_abnormal_reproductive_system1.40961537
31MP0002089_abnormal_postnatal_growth/wei1.40533541
32MP0002734_abnormal_mechanical_nocicepti1.38101238
33MP0004142_abnormal_muscle_tone1.37841225
34MP0008007_abnormal_cellular_replicative1.36372161
35MP0000428_abnormal_craniofacial_morphol1.36200661
36MP0009053_abnormal_anal_canal1.35858448
37MP0003937_abnormal_limbs/digits/tail_de1.33622294
38MP0003718_maternal_effect1.32633637
39MP0003638_abnormal_response/metabolism_1.32630556
40MP0004957_abnormal_blastocyst_morpholog1.31923558
41MP0002111_abnormal_tail_morphology1.28467935
42MP0008872_abnormal_physiological_respon1.28203515
43MP0002254_reproductive_system_inflammat1.27457371
44MP0001177_atelectasis1.22708021
45MP0005551_abnormal_eye_electrophysiolog1.21955048
46MP0000750_abnormal_muscle_regeneration1.21556160
47MP0002249_abnormal_larynx_morphology1.20108754
48MP0004145_abnormal_muscle_electrophysio1.15265309
49MP0006276_abnormal_autonomic_nervous1.12683781
50MP0003755_abnormal_palate_morphology1.12472945
51MP0009672_abnormal_birth_weight1.09557016
52MP0005389_reproductive_system_phenotype1.09432968
53MP0001286_abnormal_eye_development1.09391489
54MP0002751_abnormal_autonomic_nervous1.07068077
55MP0003890_abnormal_embryonic-extraembry1.06263343
56MP0003183_abnormal_peptide_metabolism1.05453868
57MP0002733_abnormal_thermal_nociception1.01534543
58MP0002736_abnormal_nociception_after1.01243822
59MP0005084_abnormal_gallbladder_morpholo1.00864491
60MP0001919_abnormal_reproductive_system1.00379065
61MP0003878_abnormal_ear_physiology0.96174064
62MP0005377_hearing/vestibular/ear_phenot0.96174064
63MP0000678_abnormal_parathyroid_gland0.95610690
64MP0003567_abnormal_fetal_cardiomyocyte0.94861140
65MP0002138_abnormal_hepatobiliary_system0.92960304
66MP0009046_muscle_twitch0.92637225
67MP0000733_abnormal_muscle_development0.90420405
68MP0001145_abnormal_male_reproductive0.89655725
69MP0002272_abnormal_nervous_system0.89610330
70MP0004270_analgesia0.89477025
71MP0003942_abnormal_urinary_system0.89218041
72MP0005360_urolithiasis0.89078065
73MP0008789_abnormal_olfactory_epithelium0.86545361
74MP0001970_abnormal_pain_threshold0.85522690
75MP0002752_abnormal_somatic_nervous0.85343242
76MP0002233_abnormal_nose_morphology0.82892563
77MP0000026_abnormal_inner_ear0.82579099
78MP0002116_abnormal_craniofacial_bone0.82538635
79MP0002085_abnormal_embryonic_tissue0.82317346
80MP0003137_abnormal_impulse_conducting0.82118640
81MP0000350_abnormal_cell_proliferation0.81697550
82MP0003880_abnormal_central_pattern0.80706649
83MP0003119_abnormal_digestive_system0.80390985
84MP0005195_abnormal_posterior_eye0.79346464
85MP0003861_abnormal_nervous_system0.79193794
86MP0001697_abnormal_embryo_size0.76764648
87MP0009703_decreased_birth_body0.76718327
88MP0008932_abnormal_embryonic_tissue0.74864196
89MP0000653_abnormal_sex_gland0.74300368
90MP0001963_abnormal_hearing_physiology0.73631866
91MP0000762_abnormal_tongue_morphology0.73513727
92MP0003011_delayed_dark_adaptation0.73090119
93MP0002210_abnormal_sex_determination0.72786838
94MP0002102_abnormal_ear_morphology0.69438720
95MP0006036_abnormal_mitochondrial_physio0.68310213
96MP0001542_abnormal_bone_strength0.68181475
97MP0002184_abnormal_innervation0.68071808
98MP0003936_abnormal_reproductive_system0.66927708
99MP0004130_abnormal_muscle_cell0.66926284
100MP0005253_abnormal_eye_physiology0.66858191

Predicted human phenotypes

RankGene SetZ-score
1Confusion (HP:0001289)5.05640590
2Septo-optic dysplasia (HP:0100842)4.78760947
3Pendular nystagmus (HP:0012043)4.62760678
4Acute necrotizing encephalopathy (HP:0006965)3.96668941
5Methylmalonic acidemia (HP:0002912)3.59427970
6Abnormality of homocysteine metabolism (HP:0010919)3.55445403
7Homocystinuria (HP:0002156)3.55445403
8Volvulus (HP:0002580)3.55199407
9Abolished electroretinogram (ERG) (HP:0000550)3.52084824
10Congenital, generalized hypertrichosis (HP:0004540)3.51595681
11Abnormality of methionine metabolism (HP:0010901)3.48614426
12Abnormal mitochondria in muscle tissue (HP:0008316)3.29843808
13Methylmalonic aciduria (HP:0012120)3.28253237
14Progressive macrocephaly (HP:0004481)3.20912546
15Severe visual impairment (HP:0001141)3.17481105
16Oral leukoplakia (HP:0002745)3.15999148
17Acute encephalopathy (HP:0006846)3.07720568
18Increased hepatocellular lipid droplets (HP:0006565)2.99537261
19Mitochondrial inheritance (HP:0001427)2.99314659
20Decreased central vision (HP:0007663)2.96301996
21Abnormal number of incisors (HP:0011064)2.93439812
22Dry hair (HP:0011359)2.91754693
23Truncal obesity (HP:0001956)2.88402226
24Optic nerve hypoplasia (HP:0000609)2.84601023
25Pancreatic fibrosis (HP:0100732)2.84191045
26Abnormality of aspartate family amino acid metabolism (HP:0010899)2.80666521
27Porencephaly (HP:0002132)2.76037510
28Macrocytic anemia (HP:0001972)2.75488533
29Abnormal number of erythroid precursors (HP:0012131)2.75441459
30Genetic anticipation (HP:0003743)2.74370824
31Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.69717600
32True hermaphroditism (HP:0010459)2.66622381
33Absent rod-and cone-mediated responses on ERG (HP:0007688)2.65438622
34Lipid accumulation in hepatocytes (HP:0006561)2.62991992
35Cleft eyelid (HP:0000625)2.61605267
36Pancreatic cysts (HP:0001737)2.57316781
37Woolly hair (HP:0002224)2.55880389
38Cerebral edema (HP:0002181)2.53942358
39Absent septum pellucidum (HP:0001331)2.53157803
40Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.47205994
41Short 1st metacarpal (HP:0010034)2.47205994
42Abnormality of cells of the erythroid lineage (HP:0012130)2.44417151
43Megaloblastic anemia (HP:0001889)2.42558618
443-Methylglutaconic aciduria (HP:0003535)2.42522891
45Optic disc pallor (HP:0000543)2.39310067
46Increased CSF lactate (HP:0002490)2.37334286
47Renal Fanconi syndrome (HP:0001994)2.36336593
48Progressive cerebellar ataxia (HP:0002073)2.33568385
49Agitation (HP:0000713)2.31306951
50Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.28302608
51Rib fusion (HP:0000902)2.26994608
52Facial cleft (HP:0002006)2.22603525
53Abnormality of sulfur amino acid metabolism (HP:0004339)2.21930782
54Constricted visual fields (HP:0001133)2.21781341
55Abnormality of the septum pellucidum (HP:0007375)2.20388085
56Hypoglycemic seizures (HP:0002173)2.20184243
57Abnormality of the nasolacrimal system (HP:0000614)2.18982012
58Abnormality of the 1st metacarpal (HP:0010009)2.17985126
59Maternal diabetes (HP:0009800)2.17656119
60Mesomelia (HP:0003027)2.15372426
61Abnormality of the lacrimal duct (HP:0011481)2.11506424
62Furrowed tongue (HP:0000221)2.07351368
63Abnormality of the vitamin B12 metabolism (HP:0004341)2.06256571
64Abnormality of proline metabolism (HP:0010907)2.06088434
65Hydroxyprolinuria (HP:0003080)2.06088434
66Nasolacrimal duct obstruction (HP:0000579)2.04460370
67Bilateral microphthalmos (HP:0007633)2.04231572
68Increased corneal curvature (HP:0100692)2.03716384
69Keratoconus (HP:0000563)2.03716384
70Abnormal lung lobation (HP:0002101)2.03172193
71Bony spicule pigmentary retinopathy (HP:0007737)2.01953951
72Abnormality of the axillary hair (HP:0100134)2.01778322
73Abnormality of secondary sexual hair (HP:0009888)2.01778322
74Abnormality of the nasal septum (HP:0000419)2.00826504
75Pallor (HP:0000980)1.98536514
76Hypoglycemic coma (HP:0001325)1.97232170
77Radial bowing (HP:0002986)1.94597521
78Breast aplasia (HP:0100783)1.94289850
79Reticulocytopenia (HP:0001896)1.92820435
80Intrahepatic cholestasis (HP:0001406)1.92444574
81Male pseudohermaphroditism (HP:0000037)1.90552577
82Goiter (HP:0000853)1.90383610
83Hypogonadotrophic hypogonadism (HP:0000044)1.89185540
84Short hallux (HP:0010109)1.87739414
85Abnormality of vitamin B metabolism (HP:0004340)1.87717235
86Conjunctival hamartoma (HP:0100780)1.87015456
87Hyperinsulinemic hypoglycemia (HP:0000825)1.86761247
88Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.84996084
89Hyperglycinuria (HP:0003108)1.84766354
90Sclerocornea (HP:0000647)1.83436460
91Hepatocellular necrosis (HP:0001404)1.82033116
92Abnormality of vitamin metabolism (HP:0100508)1.80906603
93Leukodystrophy (HP:0002415)1.79621188
94Pancreatic islet-cell hyperplasia (HP:0004510)1.78859980
95Abnormality of cochlea (HP:0000375)1.78751000
96Hypoplastic ischia (HP:0003175)1.78375737
97Aplasia/Hypoplasia of the breasts (HP:0010311)1.77697498
98Abnormality of the phalanges of the 2nd finger (HP:0009541)1.77165230
99Aplastic anemia (HP:0001915)1.76722622
100Proximal placement of thumb (HP:0009623)1.75487058

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAF15.69802060
2VRK24.51348934
3MARK13.39909981
4CDC72.52992988
5CASK2.46738626
6TNIK2.34231842
7NME12.21670189
8BUB12.07162325
9GRK12.06409133
10PBK2.06125714
11MAP3K910.5154782
12PNCK1.91048412
13STK161.73532431
14MST41.58887885
15VRK11.57972752
16PIK3CG1.49148674
17ADRBK21.37519204
18DYRK21.31737813
19NUAK11.29003153
20SRPK11.25052406
21AURKA0.96338051
22DDR20.93568346
23FES0.90361298
24CHEK20.88015512
25BMPR1B0.85248448
26AURKB0.84989300
27CSNK1G10.83747885
28MATK0.81200931
29PLK30.80777805
30PLK10.80509297
31TYRO30.79451321
32NTRK20.77822582
33MKNK20.76927951
34DYRK30.75170834
35PRKD20.70861287
36PINK10.63305610
37MKNK10.60377612
38NLK0.60244494
39PAK10.59172050
40SMG10.58559380
41WNK30.55312747
42TLK10.53851120
43CSNK1E0.53562467
44ARAF0.53287284
45BRSK20.52134186
46BRAF0.51241667
47CDK70.50287371
48CDK90.49984412
49ACVR1B0.49056180
50GRK60.48799418
51TTK0.48507257
52PRKCG0.47803907
53ZAK0.47672370
54NME20.46870399
55FER0.46408867
56CSNK1G30.45548242
57NEK90.45321166
58CSNK1G20.44551750
59CAMK1G0.44258145
60CSNK2A20.43705080
61SGK20.42926986
62MAPKAPK50.40992438
63PLK40.40794447
64CHEK10.40729775
65MAPK40.39569679
66INSRR0.37830281
67CAMK10.37645048
68CSNK1A10.35493941
69MAP3K100.34269403
70CSNK2A10.32993738
71ATM0.32779152
72SGK2230.32095547
73SGK4940.32095547
74GRK50.31747670
75CSNK1A1L0.29978717
76PRKDC0.28617337
77DAPK10.27574695
78NEK20.26891840
79ATR0.25829440
80MAP3K130.25570435
81OXSR10.24877855
82PRKCH0.23966815
83FGR0.23410018
84EIF2AK10.23346459
85NEK10.22644990
86CHUK0.22522007
87TAOK20.22199051
88TEC0.21216086
89CDK20.20892579
90PRKG10.20869212
91RPS6KB10.20618365
92GSK3B0.18803138
93CDK10.18341233
94PRKACA0.17609252
95EIF2AK20.16972443
96CSNK1D0.15994312
97PRKG20.15955045
98DAPK30.15887265
99RPS6KA30.15448476
100STK240.15276975

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.20530714
2Ribosome_Homo sapiens_hsa030103.89144661
3Parkinsons disease_Homo sapiens_hsa050123.51144314
4RNA polymerase_Homo sapiens_hsa030203.35762420
5Homologous recombination_Homo sapiens_hsa034403.24102200
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.79788883
7DNA replication_Homo sapiens_hsa030302.72952788
8Huntingtons disease_Homo sapiens_hsa050162.71907596
9Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.65738429
10Basal transcription factors_Homo sapiens_hsa030222.62527838
11Spliceosome_Homo sapiens_hsa030402.62453781
12One carbon pool by folate_Homo sapiens_hsa006702.59079442
13Proteasome_Homo sapiens_hsa030502.57031311
14Alzheimers disease_Homo sapiens_hsa050102.47005364
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.41421662
16Cardiac muscle contraction_Homo sapiens_hsa042602.25437410
17Vitamin digestion and absorption_Homo sapiens_hsa049772.20430465
18Maturity onset diabetes of the young_Homo sapiens_hsa049502.07777106
19Protein export_Homo sapiens_hsa030601.90220470
20Mismatch repair_Homo sapiens_hsa034301.85656664
21RNA transport_Homo sapiens_hsa030131.77343944
22RNA degradation_Homo sapiens_hsa030181.63081308
23Basal cell carcinoma_Homo sapiens_hsa052171.35883554
24Hedgehog signaling pathway_Homo sapiens_hsa043401.30209356
25Nicotine addiction_Homo sapiens_hsa050331.28057248
26Pyrimidine metabolism_Homo sapiens_hsa002401.24536290
27Melanoma_Homo sapiens_hsa052181.23530651
28Chemical carcinogenesis_Homo sapiens_hsa052041.19595307
29Pyruvate metabolism_Homo sapiens_hsa006201.14241538
30Tryptophan metabolism_Homo sapiens_hsa003801.11057242
31Taste transduction_Homo sapiens_hsa047421.08891050
32Non-homologous end-joining_Homo sapiens_hsa034501.07997537
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.06259770
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.04273875
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.02976892
36Nucleotide excision repair_Homo sapiens_hsa034201.02150797
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.99983004
38Phototransduction_Homo sapiens_hsa047440.99802278
39Base excision repair_Homo sapiens_hsa034100.99269816
40Fanconi anemia pathway_Homo sapiens_hsa034600.98032318
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.96218915
42Cell cycle_Homo sapiens_hsa041100.95745223
43Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.94350453
44Purine metabolism_Homo sapiens_hsa002300.93498219
45Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.91641127
46Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.86366727
47Wnt signaling pathway_Homo sapiens_hsa043100.84954425
48Glutathione metabolism_Homo sapiens_hsa004800.83196951
49Nitrogen metabolism_Homo sapiens_hsa009100.79650373
50Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.78433333
51Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.70183774
52Folate biosynthesis_Homo sapiens_hsa007900.67982024
53mRNA surveillance pathway_Homo sapiens_hsa030150.66002292
54Cysteine and methionine metabolism_Homo sapiens_hsa002700.64181007
55Systemic lupus erythematosus_Homo sapiens_hsa053220.63824381
56Pentose and glucuronate interconversions_Homo sapiens_hsa000400.63429936
57Retinol metabolism_Homo sapiens_hsa008300.61919572
58Oocyte meiosis_Homo sapiens_hsa041140.60609203
59Linoleic acid metabolism_Homo sapiens_hsa005910.57721373
60Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.56976068
61Sulfur metabolism_Homo sapiens_hsa009200.54306241
62Selenocompound metabolism_Homo sapiens_hsa004500.54085106
63Fat digestion and absorption_Homo sapiens_hsa049750.52459335
64Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48144248
65Metabolic pathways_Homo sapiens_hsa011000.43948765
66Morphine addiction_Homo sapiens_hsa050320.42933682
67TGF-beta signaling pathway_Homo sapiens_hsa043500.40786479
68Thyroid cancer_Homo sapiens_hsa052160.40532065
69Caffeine metabolism_Homo sapiens_hsa002320.37879835
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36630134
71Glycerolipid metabolism_Homo sapiens_hsa005610.35356632
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.32547478
73Prostate cancer_Homo sapiens_hsa052150.31488629
74Propanoate metabolism_Homo sapiens_hsa006400.31307821
75Olfactory transduction_Homo sapiens_hsa047400.30000840
76Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.29910656
77Serotonergic synapse_Homo sapiens_hsa047260.29695973
78Steroid hormone biosynthesis_Homo sapiens_hsa001400.29052455
79Fatty acid degradation_Homo sapiens_hsa000710.27232218
80alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27185672
81beta-Alanine metabolism_Homo sapiens_hsa004100.25130505
82GABAergic synapse_Homo sapiens_hsa047270.25095892
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.24626235
84Epstein-Barr virus infection_Homo sapiens_hsa051690.23937964
85Hippo signaling pathway_Homo sapiens_hsa043900.22548703
86Glutamatergic synapse_Homo sapiens_hsa047240.21791132
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.21322513
88Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.20639308
89Melanogenesis_Homo sapiens_hsa049160.20371461
90Butanoate metabolism_Homo sapiens_hsa006500.19909556
91Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.19874026
92Renin-angiotensin system_Homo sapiens_hsa046140.19428278
93Tight junction_Homo sapiens_hsa045300.19247986
94Fatty acid biosynthesis_Homo sapiens_hsa000610.17713824
95Thyroid hormone synthesis_Homo sapiens_hsa049180.17240085
96Histidine metabolism_Homo sapiens_hsa003400.15795631
97Primary immunodeficiency_Homo sapiens_hsa053400.15718039
98Gap junction_Homo sapiens_hsa045400.15297033
99Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.15150868
100Calcium signaling pathway_Homo sapiens_hsa040200.14686280

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