CYCSP38

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)9.93815849
2motile cilium assembly (GO:0044458)9.89126483
3epithelial cilium movement (GO:0003351)8.63455776
4regulation of cilium movement (GO:0003352)6.94058658
5ventricular system development (GO:0021591)6.82465993
6response to interleukin-15 (GO:0070672)5.96817005
7positive regulation of natural killer cell differentiation (GO:0032825)5.48848787
8regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)5.34181898
9microtubule bundle formation (GO:0001578)4.74045143
10cellular response to interleukin-15 (GO:0071350)4.60495535
11regulation of DNA endoreduplication (GO:0032875)4.50870733
12positive regulation of gamma-delta T cell activation (GO:0046645)4.50229925
13regulation of interleukin-8 biosynthetic process (GO:0045414)4.31995847
14eye photoreceptor cell development (GO:0042462)4.30013995
15regulation of gamma-delta T cell differentiation (GO:0045586)4.25951071
16regulation of interleukin-2 biosynthetic process (GO:0045076)4.17364964
17photoreceptor cell development (GO:0042461)4.15399926
18left/right pattern formation (GO:0060972)4.06511265
19photoreceptor cell maintenance (GO:0045494)4.05865198
20regulation of cytokine production involved in inflammatory response (GO:1900015)4.05114766
21neural tube formation (GO:0001841)4.03961451
22positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.98427453
23left/right axis specification (GO:0070986)3.95108018
24interferon-gamma production (GO:0032609)3.84512433
25regulation of microtubule-based movement (GO:0060632)3.72699676
26cilium organization (GO:0044782)3.72538628
27regulation of gamma-delta T cell activation (GO:0046643)3.66819294
28regulation of natural killer cell differentiation (GO:0032823)3.65367341
29peristalsis (GO:0030432)3.64618119
30inflammatory response to antigenic stimulus (GO:0002437)3.62628871
31hematopoietic stem cell proliferation (GO:0071425)3.49406916
32regulation of interleukin-6 biosynthetic process (GO:0045408)3.46038266
33positive regulation of natural killer cell activation (GO:0032816)3.44877204
34positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.41108372
35alpha-beta T cell differentiation (GO:0046632)3.38974543
36RNA destabilization (GO:0050779)3.31429664
37mature B cell differentiation (GO:0002335)3.23065095
38regulation of hippo signaling (GO:0035330)3.18957952
39microtubule-based movement (GO:0007018)3.17238880
40brain morphogenesis (GO:0048854)3.16947263
41early endosome to late endosome transport (GO:0045022)3.11628195
42hepatocyte differentiation (GO:0070365)3.11487578
43cornea development in camera-type eye (GO:0061303)3.02313536
44negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.97825670
45negative regulation of translation, ncRNA-mediated (GO:0040033)2.97825670
46regulation of translation, ncRNA-mediated (GO:0045974)2.97825670
47cilium assembly (GO:0042384)2.94447978
48cilium morphogenesis (GO:0060271)2.94242544
49valine metabolic process (GO:0006573)2.90902961
50positive regulation by symbiont of host defense response (GO:0052509)2.87024628
51modulation by symbiont of host defense response (GO:0052031)2.87024628
52modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.87024628
53modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.87024628
54positive regulation by organism of defense response of other organism involved in symbiotic interact2.87024628
55modulation by symbiont of host immune response (GO:0052553)2.87024628
56alpha-beta T cell activation (GO:0046631)2.84806945
57cytokine biosynthetic process (GO:0042089)2.84056723
58cellular component assembly involved in morphogenesis (GO:0010927)2.81814837
59sympathetic nervous system development (GO:0048485)2.80938426
60glial cell proliferation (GO:0014009)2.79544160
61negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.77922899
62positive regulation of B cell differentiation (GO:0045579)2.77746684
63lateral ventricle development (GO:0021670)2.75419217
64alkaloid metabolic process (GO:0009820)2.75105625
65positive T cell selection (GO:0043368)2.73792326
66positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.72236402
67fat-soluble vitamin biosynthetic process (GO:0042362)2.71557373
68T cell differentiation involved in immune response (GO:0002292)2.71146228
69alpha-beta T cell differentiation involved in immune response (GO:0002293)2.71146228
70alpha-beta T cell activation involved in immune response (GO:0002287)2.71146228
71protein localization to cilium (GO:0061512)2.68961223
72monoubiquitinated protein deubiquitination (GO:0035520)2.68627395
73microtubule depolymerization (GO:0007019)2.68332321
74indolalkylamine metabolic process (GO:0006586)2.67107856
75C4-dicarboxylate transport (GO:0015740)2.65368202
76CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.64054453
77T-helper cell differentiation (GO:0042093)2.64054453
78regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.63416652
79intraciliary transport (GO:0042073)2.63359457
80regulation of interleukin-5 production (GO:0032674)2.63167527
81mast cell degranulation (GO:0043303)2.62819566
82mast cell activation involved in immune response (GO:0002279)2.62819566
83mucosal-associated lymphoid tissue development (GO:0048537)2.61418802
84Peyers patch development (GO:0048541)2.61418802
85multicellular organismal aging (GO:0010259)2.60397157
86protein localization to microtubule cytoskeleton (GO:0072698)2.58767062
87positive regulation of natural killer cell mediated immunity (GO:0002717)2.58519302
88negative T cell selection (GO:0043383)2.56756450
89pericardium development (GO:0060039)2.54890108
90ubiquinone biosynthetic process (GO:0006744)2.52892530
91T cell mediated immunity (GO:0002456)2.52409654
92activated T cell proliferation (GO:0050798)2.47907807
93regulation of natural killer cell activation (GO:0032814)2.45950924
94cytokine metabolic process (GO:0042107)2.45381941
95cilium or flagellum-dependent cell motility (GO:0001539)17.0447994
96epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)13.7407823
97retinal cone cell development (GO:0046549)11.5988310
98retinal rod cell development (GO:0046548)11.1667994
99cilium movement (GO:0003341)11.0464524
100axoneme assembly (GO:0035082)10.8134539

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse7.13801015
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse5.24530154
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.19953026
4AR_21572438_ChIP-Seq_LNCaP_Human3.63413212
5IGF1R_20145208_ChIP-Seq_DFB_Human3.53907514
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.45793133
7FLI1_27457419_Chip-Seq_LIVER_Mouse3.34460884
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.04281093
9PCGF2_27294783_Chip-Seq_ESCs_Mouse2.61714898
10VDR_22108803_ChIP-Seq_LS180_Human2.39551333
11GATA1_22025678_ChIP-Seq_K562_Human2.25014612
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.11516548
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.10212625
14SUZ12_27294783_Chip-Seq_NPCs_Mouse1.99373298
15AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.99064389
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.98322571
17SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.87887987
18NFE2_27457419_Chip-Seq_LIVER_Mouse1.87489903
19SMAD4_21799915_ChIP-Seq_A2780_Human1.78627385
20POU3F2_20337985_ChIP-ChIP_501MEL_Human1.69347903
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.68770399
22TP53_16413492_ChIP-PET_HCT116_Human1.67964654
23DROSHA_22980978_ChIP-Seq_HELA_Human1.65357989
24ZNF274_21170338_ChIP-Seq_K562_Hela1.63847581
25GBX2_23144817_ChIP-Seq_PC3_Human1.60972263
26FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.55597213
27ZFP57_27257070_Chip-Seq_ESCs_Mouse1.53906096
28FOXM1_26456572_ChIP-Seq_MCF-7_Human1.53843730
29EZH2_27294783_Chip-Seq_NPCs_Mouse1.51430518
30CBP_20019798_ChIP-Seq_JUKART_Human1.51067832
31IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.51067832
32TOP2B_26459242_ChIP-Seq_MCF-7_Human1.49091480
33STAT3_23295773_ChIP-Seq_U87_Human1.48169264
34PIAS1_25552417_ChIP-Seq_VCAP_Human1.46806605
35TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.46247700
36SALL1_21062744_ChIP-ChIP_HESCs_Human1.45906976
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.44675327
38RUNX_20019798_ChIP-Seq_JUKART_Human1.44526548
39TAF15_26573619_Chip-Seq_HEK293_Human1.43326896
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.42928084
41PCGF2_27294783_Chip-Seq_NPCs_Mouse1.40315529
42NR3C1_21868756_ChIP-Seq_MCF10A_Human1.40255854
43PRDM14_20953172_ChIP-Seq_ESCs_Human1.34139664
44ER_23166858_ChIP-Seq_MCF-7_Human1.32194902
45BCAT_22108803_ChIP-Seq_LS180_Human1.32133687
46IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.30108527
47ZNF217_24962896_ChIP-Seq_MCF-7_Human1.29692971
48CTBP2_25329375_ChIP-Seq_LNCAP_Human1.29254029
49SMRT_27268052_Chip-Seq_Bcells_Human1.28616808
50EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.25720551
51MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.24368063
52P53_22387025_ChIP-Seq_ESCs_Mouse1.23711016
53UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21350162
54P300_19829295_ChIP-Seq_ESCs_Human1.18665348
55TCF4_23295773_ChIP-Seq_U87_Human1.18205289
56CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.17752394
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.17728844
58SMAD_19615063_ChIP-ChIP_OVARY_Human1.17520008
59FUS_26573619_Chip-Seq_HEK293_Human1.16109978
60NANOG_19829295_ChIP-Seq_ESCs_Human1.15906802
61SOX2_19829295_ChIP-Seq_ESCs_Human1.15906802
62ESR1_20079471_ChIP-ChIP_T-47D_Human1.13074245
63SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12640735
64ARNT_22903824_ChIP-Seq_MCF-7_Human1.12072397
65GATA3_26560356_Chip-Seq_TH2_Human1.11265309
66STAT3_18555785_Chip-Seq_ESCs_Mouse1.10796988
67VDR_24787735_ChIP-Seq_THP-1_Human1.10052175
68E2F1_18555785_Chip-Seq_ESCs_Mouse1.09224808
69TCF4_22108803_ChIP-Seq_LS180_Human1.08804628
70EWS_26573619_Chip-Seq_HEK293_Human1.08602883
71OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08473272
72NANOG_18555785_Chip-Seq_ESCs_Mouse1.08332461
73CRX_20693478_ChIP-Seq_RETINA_Mouse1.07752176
74BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.07548437
75NOTCH1_21737748_ChIP-Seq_TLL_Human1.07425634
76KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06633892
77GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05913100
78TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05478750
79ELK4_26923725_Chip-Seq_MESODERM_Mouse1.03867541
80PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03652799
81AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.03396510
82OCT4_18555785_Chip-Seq_ESCs_Mouse1.02546398
83ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.01982373
84AHR_22903824_ChIP-Seq_MCF-7_Human1.00487268
85SMAD3_21741376_ChIP-Seq_HESCs_Human0.99764293
86TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99367411
87CMYC_18555785_Chip-Seq_ESCs_Mouse0.99007939
88SOX2_18555785_Chip-Seq_ESCs_Mouse0.97641036
89EP300_21415370_ChIP-Seq_HL-1_Mouse0.96521994
90OCT4_21477851_ChIP-Seq_ESCs_Mouse0.95767149
91CTCF_18555785_Chip-Seq_ESCs_Mouse0.95175344
92SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94695738
93EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.94577723
94TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.94087993
95FOXA1_21572438_ChIP-Seq_LNCaP_Human0.93958139
96P300_18555785_Chip-Seq_ESCs_Mouse0.93559773
97ZFX_18555785_Chip-Seq_ESCs_Mouse0.93458309
98SUZ12_18555785_Chip-Seq_ESCs_Mouse0.93215189
99RUNX2_22187159_ChIP-Seq_PCA_Human0.92820332
100AR_25329375_ChIP-Seq_VCAP_Human0.92679313

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001873_stomach_inflammation3.96598055
2MP0005623_abnormal_meninges_morphology3.77399418
3MP0001790_abnormal_immune_system3.64851913
4MP0005387_immune_system_phenotype3.64851913
5MP0002653_abnormal_ependyma_morphology3.58495565
6MP0009384_cardiac_valve_regurgitation3.43003602
7MP0004043_abnormal_pH_regulation3.36521919
8MP0005253_abnormal_eye_physiology3.33997868
9MP0008057_abnormal_DNA_replication2.75942757
10MP0001800_abnormal_humoral_immune2.54763336
11MP0005671_abnormal_response_to2.47980047
12MP0001346_abnormal_lacrimal_gland2.44764434
13MP0001835_abnormal_antigen_presentation2.39084046
14MP0003950_abnormal_plasma_membrane2.37886154
15MP0000372_irregular_coat_pigmentation2.37136401
16MP0004381_abnormal_hair_follicle2.35927163
17MP0005551_abnormal_eye_electrophysiolog2.31394168
18MP0003763_abnormal_thymus_physiology2.28318303
19MP0005075_abnormal_melanosome_morpholog2.24811717
20MP0000465_gastrointestinal_hemorrhage2.08177779
21MP0002405_respiratory_system_inflammati2.07773693
22MP0000569_abnormal_digit_pigmentation2.00293390
23MP0008875_abnormal_xenobiotic_pharmacok1.99836375
24MP0005083_abnormal_biliary_tract1.88702719
25MP0002723_abnormal_immune_serum1.80319719
26MP0002933_joint_inflammation1.74477357
27MP0005000_abnormal_immune_tolerance1.71288448
28MP0008961_abnormal_basal_metabolism1.67869399
29MP0000015_abnormal_ear_pigmentation1.65465097
30MP0003866_abnormal_defecation1.61285342
31MP0005174_abnormal_tail_pigmentation1.58928273
32MP0003195_calcinosis1.58151929
33MP0002452_abnormal_antigen_presenting1.54016762
34MP0005360_urolithiasis1.52092776
35MP0001986_abnormal_taste_sensitivity1.51167989
36MP0010329_abnormal_lipoprotein_level1.49578192
37MP0002148_abnormal_hypersensitivity_rea1.45817598
38MP0006082_CNS_inflammation1.45544237
39MP0002420_abnormal_adaptive_immunity1.40732619
40MP0001819_abnormal_immune_cell1.39623354
41MP0000383_abnormal_hair_follicle1.33215161
42MP0009046_muscle_twitch1.28360096
43MP0001845_abnormal_inflammatory_respons1.26157242
44MP0002277_abnormal_respiratory_mucosa1.25910430
45MP0005391_vision/eye_phenotype1.22400125
46MP0001666_abnormal_nutrient_absorption1.18612312
47MP0004264_abnormal_extraembryonic_tissu1.15276963
48MP0005377_hearing/vestibular/ear_phenot1.14662142
49MP0003878_abnormal_ear_physiology1.14662142
50MP0002876_abnormal_thyroid_physiology1.13909581
51MP0010155_abnormal_intestine_physiology1.13837533
52MP0005645_abnormal_hypothalamus_physiol1.12769910
53MP0010368_abnormal_lymphatic_system1.06685637
54MP0001851_eye_inflammation1.05691592
55MP0005085_abnormal_gallbladder_physiolo1.02671643
56MP0000689_abnormal_spleen_morphology1.01424924
57MP0009765_abnormal_xenobiotic_induced0.98110749
58MP0001324_abnormal_eye_pigmentation0.97855341
59MP0010678_abnormal_skin_adnexa0.95080782
60MP0002282_abnormal_trachea_morphology0.94795429
61MP0000716_abnormal_immune_system0.94655734
62MP0005025_abnormal_response_to0.94480289
63MP0005195_abnormal_posterior_eye0.93625422
64MP0005408_hypopigmentation0.93570562
65MP0001663_abnormal_digestive_system0.90208323
66MP0002229_neurodegeneration0.89090868
67MP0004145_abnormal_muscle_electrophysio0.88494642
68MP0000703_abnormal_thymus_morphology0.86802539
69MP0006072_abnormal_retinal_apoptosis0.86364692
70MP0001486_abnormal_startle_reflex0.86272738
71MP0005646_abnormal_pituitary_gland0.84971708
72MP0002398_abnormal_bone_marrow0.83884564
73MP0002136_abnormal_kidney_physiology0.83178823
74MP0000639_abnormal_adrenal_gland0.82586509
75MP0009764_decreased_sensitivity_to0.80762391
76MP0002138_abnormal_hepatobiliary_system0.80141079
77MP0000427_abnormal_hair_cycle0.78300465
78MP0009643_abnormal_urine_homeostasis0.75939409
79MP0009840_abnormal_foam_cell0.74879935
80MP0000371_diluted_coat_color0.74868399
81MP0002102_abnormal_ear_morphology0.74625268
82MP0002722_abnormal_immune_system0.74579623
83MP0002095_abnormal_skin_pigmentation0.74376931
84MP0002419_abnormal_innate_immunity0.72106990
85MP0004134_abnormal_chest_morphology0.71564151
86MP0009115_abnormal_fat_cell0.70676136
87MP0003045_fibrosis0.68610724
88MP0001944_abnormal_pancreas_morphology0.65340097
89MP0003646_muscle_fatigue0.64389244
90MP0009785_altered_susceptibility_to0.64012587
91MP0005670_abnormal_white_adipose0.63519940
92MP0002135_abnormal_kidney_morphology0.62822373
93MP0002234_abnormal_pharynx_morphology0.61122937
94MP0002118_abnormal_lipid_homeostasis0.59792154
95MP0005365_abnormal_bile_salt0.59570787
96MP0002168_other_aberrant_phenotype0.59312923
97MP0003436_decreased_susceptibility_to0.58229497
98MP0001501_abnormal_sleep_pattern0.56968051
99MP0001984_abnormal_olfaction0.56723439
100MP0002166_altered_tumor_susceptibility0.55274870

Predicted human phenotypes

RankGene SetZ-score
1Abnormal ciliary motility (HP:0012262)8.31513041
2Abnormal respiratory motile cilium morphology (HP:0005938)7.65735836
3Abnormal respiratory epithelium morphology (HP:0012253)7.65735836
4Abnormal respiratory motile cilium physiology (HP:0012261)7.09248797
5Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.05717577
6Abnormal rod and cone electroretinograms (HP:0008323)6.31361143
7Chronic hepatic failure (HP:0100626)6.26950814
8Tubulointerstitial nephritis (HP:0001970)5.23776847
9Rhinitis (HP:0012384)4.78265544
10Chronic bronchitis (HP:0004469)4.54040333
11Bronchiectasis (HP:0002110)4.38432065
12Bronchitis (HP:0012387)4.02998430
13Chronic mucocutaneous candidiasis (HP:0002728)3.97049753
14Recurrent cutaneous fungal infections (HP:0011370)3.97049753
15Nasal polyposis (HP:0100582)3.86326373
16Constricted visual fields (HP:0001133)3.79392404
17Recurrent bronchitis (HP:0002837)3.67907121
18Chronic sinusitis (HP:0011109)3.32105186
19Bony spicule pigmentary retinopathy (HP:0007737)3.27769642
20Abnormality of the fingertips (HP:0001211)3.25276568
21Abnormality of the nasal mucosa (HP:0000433)3.06721440
22Hypoalphalipoproteinemia (HP:0003233)3.05825379
23Recurrent sinusitis (HP:0011108)2.95047604
24Dyschromatopsia (HP:0007641)2.92614193
25T lymphocytopenia (HP:0005403)2.74267657
26Menstrual irregularities (HP:0000858)2.67377177
27Cone-rod dystrophy (HP:0000548)2.59402564
28Heterotopia (HP:0002282)2.52158349
29Joint swelling (HP:0001386)2.49152852
30Recurrent otitis media (HP:0000403)2.47655845
31Abnormal hair whorl (HP:0010721)2.44180624
32Abnormality of T cell number (HP:0011839)2.43941296
33Tubulointerstitial abnormality (HP:0001969)2.35948887
34Vitreoretinal degeneration (HP:0000655)2.33200333
35Recurrent fungal infections (HP:0002841)2.21879099
36Renovascular hypertension (HP:0100817)2.21486142
37Nephronophthisis (HP:0000090)2.19575148
38Anteriorly placed anus (HP:0001545)2.18051702
39Hepatitis (HP:0012115)2.14824352
40Abnormality of the renal medulla (HP:0100957)2.11208039
41Decreased circulating renin level (HP:0003351)2.10321084
42Progressive sensorineural hearing impairment (HP:0000408)2.05322627
43Molar tooth sign on MRI (HP:0002419)2.03009924
44Abnormality of midbrain morphology (HP:0002418)2.03009924
45Chronic diarrhea (HP:0002028)2.02144287
46Absent/shortened dynein arms (HP:0200106)12.5557012
47Dynein arm defect of respiratory motile cilia (HP:0012255)12.5557012
48Absent rod-and cone-mediated responses on ERG (HP:0007688)10.0273985
49Pigmentary retinal degeneration (HP:0001146)1.96166014
50Neonatal hypoglycemia (HP:0001998)1.92012932
51Chronic otitis media (HP:0000389)1.87367986
52Stomatitis (HP:0010280)1.87241309
53Hyperactive renin-angiotensin system (HP:0000841)1.86644753
54Abnormal delayed hypersensitivity skin test (HP:0002963)1.85895353
55Hypolipoproteinemia (HP:0010981)1.83159878
56IgA deficiency (HP:0002720)1.79557606
57Infertility (HP:0000789)1.79489578
58Long nose (HP:0003189)1.78129300
59Insulin-resistant diabetes mellitus (HP:0000831)1.77984795
60IgG deficiency (HP:0004315)1.77849736
61Cheilitis (HP:0100825)1.75855894
62Abnormality of T cells (HP:0002843)1.73572672
63Scanning speech (HP:0002168)1.72115790
64Macroorchidism (HP:0000053)1.70573912
65Portal hypertension (HP:0001409)1.69470975
66Cellular immunodeficiency (HP:0005374)1.67484010
67Hypokalemic alkalosis (HP:0001949)1.62037234
68Gingivitis (HP:0000230)1.61503785
69Nephrogenic diabetes insipidus (HP:0009806)1.61439704
70Premature skin wrinkling (HP:0100678)1.60625777
71Truncal obesity (HP:0001956)1.59431931
72Medial flaring of the eyebrow (HP:0010747)1.58283930
73Astrocytoma (HP:0009592)1.57871399
74Abnormality of the astrocytes (HP:0100707)1.57871399
75Partial agenesis of the corpus callosum (HP:0001338)1.57684816
76Lissencephaly (HP:0001339)1.56792692
77Renal salt wasting (HP:0000127)1.55618023
78Obsessive-compulsive behavior (HP:0000722)1.54217771
79Supernumerary spleens (HP:0009799)1.52610083
80Abnormality of the hepatic vasculature (HP:0006707)1.51264863
81Abolished electroretinogram (ERG) (HP:0000550)1.50012350
82Occipital encephalocele (HP:0002085)1.49671568
83Gaze-evoked nystagmus (HP:0000640)1.47991474
84Ependymoma (HP:0002888)1.47794277
85Macular degeneration (HP:0000608)1.47502443
86Hyperuricemia (HP:0002149)1.47078130
87Increased purine levels (HP:0004368)1.47078130
88Pulmonary fibrosis (HP:0002206)1.46486776
89Abnormality of the renal cortex (HP:0011035)1.45794591
90Subcapsular cataract (HP:0000523)1.45575161
91Recurrent skin infections (HP:0001581)1.45217691
92Recurrent pneumonia (HP:0006532)1.43593009
93Hemoptysis (HP:0002105)1.42994349
94Abnormality of T cell physiology (HP:0011840)1.42928979
95Aortic aneurysm (HP:0004942)1.36900597
96Hyperkalemia (HP:0002153)1.35419214
97Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.34977194
98Increased IgM level (HP:0003496)1.34837640
99Type II diabetes mellitus (HP:0005978)1.34433900
100Delayed closure of the anterior fontanelle (HP:0001476)1.34236172

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK7.03986823
2TAOK36.54159684
3TRIM284.18342241
4TYK23.36649732
5BCR3.01141286
6STK162.94714429
7FRK2.84192328
8CDK122.38811181
9MAPK152.35931113
10EPHA42.30954042
11MST42.27500828
12SGK21.57014519
13MAP4K11.49149602
14CASK1.44578027
15BUB11.41267818
16IRAK11.38920061
17ZAP701.19881745
18IKBKE1.16689016
19ERBB21.14011981
20CDK81.11760657
21ERBB31.09500677
22ADRBK21.09275830
23AKT31.07566707
24BLK1.07440798
25PTK2B1.05977996
26FGFR21.00265087
27GRK10.99622784
28CSNK1A1L0.93271569
29NUAK10.90295120
30MAP3K20.89384463
31CAMK1G0.88864635
32SGK30.88638365
33MAP4K20.84016803
34CSK0.82928281
35SGK4940.82373616
36SGK2230.82373616
37WNK30.81154279
38TNK20.80721609
39MST1R0.80074784
40JAK10.79597694
41PAK30.74940970
42PNCK0.74835628
43MAP3K30.74639666
44SYK0.72852534
45TBK10.72811334
46JAK20.68543075
47MAP2K60.67999472
48IKBKB0.67923976
49PRKCQ0.67812810
50MARK10.65379924
51STK100.64105537
52PTK60.63819185
53TRPM70.60474507
54TEC0.59642140
55TAF10.58771135
56FES0.58723413
57MAP3K70.56774145
58TYRO30.56430562
59BMPR1B0.56000609
60KSR20.54891358
61MUSK0.51598803
62WNK40.50859732
63EGFR0.50122262
64IRAK40.49958281
65IRAK20.49495617
66HCK0.49046533
67ITK0.48083258
68WNK10.47834407
69NME10.47529014
70MAP3K40.46192288
71IGF1R0.46005036
72ACVR1B0.43171947
73LYN0.42668456
74STK110.42184237
75CAMK1D0.38544551
76INSRR0.38155996
77FYN0.37177429
78STK380.37141923
79PRKG10.37008895
80ADRBK10.35956806
81ATM0.35811036
82EIF2AK20.33489366
83STK38L0.32244813
84MAPK30.31759985
85STK30.31422808
86MAPK80.30248061
87MAPKAPK20.28971770
88OXSR10.28704324
89DAPK20.27236300
90PRKAA20.27020334
91MAP2K10.25584413
92PDGFRB0.25100069
93LCK0.24724572
94MAPK110.24436923
95GRK50.22320204
96STK390.22278332
97EPHB10.21205438
98OBSCN0.21104367
99SGK10.20280304
100MAPK10.20079368

Predicted pathways (KEGG)

RankGene SetZ-score
1Inflammatory bowel disease (IBD)_Homo sapiens_hsa053214.05361567
2Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006013.51422011
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.97344264
4T cell receptor signaling pathway_Homo sapiens_hsa046602.47124433
5Caffeine metabolism_Homo sapiens_hsa002322.36416306
6ABC transporters_Homo sapiens_hsa020102.36202736
7Jak-STAT signaling pathway_Homo sapiens_hsa046302.35184705
8Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.19473094
9Linoleic acid metabolism_Homo sapiens_hsa005912.13204523
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.09882101
11Primary immunodeficiency_Homo sapiens_hsa053402.05561446
12Intestinal immune network for IgA production_Homo sapiens_hsa046722.04628837
13Sphingolipid metabolism_Homo sapiens_hsa006002.02400569
14Hematopoietic cell lineage_Homo sapiens_hsa046401.94602285
15Non-homologous end-joining_Homo sapiens_hsa034501.93413591
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.91735950
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.78509490
18Tryptophan metabolism_Homo sapiens_hsa003801.73474089
19Circadian rhythm_Homo sapiens_hsa047101.64220182
20Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.59317079
21Measles_Homo sapiens_hsa051621.56732672
22Allograft rejection_Homo sapiens_hsa053301.54449330
23Chemical carcinogenesis_Homo sapiens_hsa052041.54347621
24Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.52522975
25Nitrogen metabolism_Homo sapiens_hsa009101.48380274
26Huntingtons disease_Homo sapiens_hsa050161.44142306
27Autoimmune thyroid disease_Homo sapiens_hsa053201.40481202
28Dorso-ventral axis formation_Homo sapiens_hsa043201.40459939
29Graft-versus-host disease_Homo sapiens_hsa053321.37373285
30Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.31538027
31alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.27475056
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.24532339
33Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.19875474
34Retinol metabolism_Homo sapiens_hsa008301.17344257
35Vitamin digestion and absorption_Homo sapiens_hsa049771.14636434
36Viral myocarditis_Homo sapiens_hsa054161.11918531
37Pentose and glucuronate interconversions_Homo sapiens_hsa000401.11294061
38Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.10288019
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.04289271
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.97832406
41Regulation of autophagy_Homo sapiens_hsa041400.97672307
42Basal transcription factors_Homo sapiens_hsa030220.95618118
43Nicotine addiction_Homo sapiens_hsa050330.90969618
44Taste transduction_Homo sapiens_hsa047420.88783335
45Sphingolipid signaling pathway_Homo sapiens_hsa040710.85002718
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.83046778
47Butanoate metabolism_Homo sapiens_hsa006500.82700097
48Lysine degradation_Homo sapiens_hsa003100.81971613
49Osteoclast differentiation_Homo sapiens_hsa043800.76051811
50NF-kappa B signaling pathway_Homo sapiens_hsa040640.75072551
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74952286
52Sulfur metabolism_Homo sapiens_hsa009200.73786221
53Phototransduction_Homo sapiens_hsa047440.69985574
54Fatty acid elongation_Homo sapiens_hsa000620.68858892
55B cell receptor signaling pathway_Homo sapiens_hsa046620.68756137
56Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.67680192
57Fatty acid biosynthesis_Homo sapiens_hsa000610.67545591
58Ether lipid metabolism_Homo sapiens_hsa005650.66418024
59Transcriptional misregulation in cancer_Homo sapiens_hsa052020.63669073
60NOD-like receptor signaling pathway_Homo sapiens_hsa046210.63267471
61Ovarian steroidogenesis_Homo sapiens_hsa049130.63017666
62Arachidonic acid metabolism_Homo sapiens_hsa005900.60454081
63Fatty acid metabolism_Homo sapiens_hsa012120.58942449
64HTLV-I infection_Homo sapiens_hsa051660.57472442
65Antigen processing and presentation_Homo sapiens_hsa046120.56914559
66Hepatitis B_Homo sapiens_hsa051610.53725582
67Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.53406891
68Type I diabetes mellitus_Homo sapiens_hsa049400.52902396
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48881786
70Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.48868005
71Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.48215721
72AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.48097060
73MAPK signaling pathway_Homo sapiens_hsa040100.46967097
74Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46580645
75TNF signaling pathway_Homo sapiens_hsa046680.46461288
76Histidine metabolism_Homo sapiens_hsa003400.46167358
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40513475
78Propanoate metabolism_Homo sapiens_hsa006400.40185126
79cAMP signaling pathway_Homo sapiens_hsa040240.40058641
80Chemokine signaling pathway_Homo sapiens_hsa040620.39107057
81Fatty acid degradation_Homo sapiens_hsa000710.38855266
82Complement and coagulation cascades_Homo sapiens_hsa046100.37091334
83Salivary secretion_Homo sapiens_hsa049700.35977596
84Drug metabolism - other enzymes_Homo sapiens_hsa009830.35863314
85Peroxisome_Homo sapiens_hsa041460.35325374
86Vascular smooth muscle contraction_Homo sapiens_hsa042700.34937891
87Hepatitis C_Homo sapiens_hsa051600.33488577
88Glycerolipid metabolism_Homo sapiens_hsa005610.33268024
89Asthma_Homo sapiens_hsa053100.32211399
90ErbB signaling pathway_Homo sapiens_hsa040120.31512104
91Calcium signaling pathway_Homo sapiens_hsa040200.31194041
92Platelet activation_Homo sapiens_hsa046110.31128318
93Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.30278373
94Pentose phosphate pathway_Homo sapiens_hsa000300.29462833
95Inositol phosphate metabolism_Homo sapiens_hsa005620.27458847
96mTOR signaling pathway_Homo sapiens_hsa041500.26108300
97Colorectal cancer_Homo sapiens_hsa052100.24886652
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.23916026
99Pancreatic secretion_Homo sapiens_hsa049720.23828353
100Prolactin signaling pathway_Homo sapiens_hsa049170.23309085

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