CYCSP52

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-fucose catabolic process (GO:0042355)9.17731691
2fucose catabolic process (GO:0019317)9.17731691
3L-fucose metabolic process (GO:0042354)9.17731691
4pyrimidine dimer repair (GO:0006290)8.75950275
5histone H2A monoubiquitination (GO:0035518)5.80585598
6fucose metabolic process (GO:0006004)5.15983165
7histone H2A ubiquitination (GO:0033522)5.06747903
8establishment of protein localization to mitochondrial membrane (GO:0090151)4.94391268
9left/right axis specification (GO:0070986)4.68555274
10fucosylation (GO:0036065)4.65474440
11sulfation (GO:0051923)4.63933227
12relaxation of smooth muscle (GO:0044557)4.38805604
13cellular response to arsenic-containing substance (GO:0071243)4.33729976
14negative regulation of response to food (GO:0032096)4.27830387
15negative regulation of appetite (GO:0032099)4.27830387
16resolution of meiotic recombination intermediates (GO:0000712)4.26852065
17positive regulation of developmental pigmentation (GO:0048087)4.23354391
18negative regulation of smooth muscle contraction (GO:0045986)4.20662149
19secondary metabolite biosynthetic process (GO:0044550)4.17770283
20nonmotile primary cilium assembly (GO:0035058)4.17411104
21cilium morphogenesis (GO:0060271)4.04674739
22epithelial cilium movement (GO:0003351)4.02890147
23generation of neurons (GO:0048699)3.91242032
24otic vesicle formation (GO:0030916)3.89826348
25regulation of pigment cell differentiation (GO:0050932)3.78743404
26left/right pattern formation (GO:0060972)3.77568094
27DNA excision (GO:0044349)3.77393727
28nucleotide-excision repair, DNA damage removal (GO:0000718)3.77393727
29purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.74003472
303-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.74003472
31maturation of SSU-rRNA (GO:0030490)3.59709953
32anterior/posterior axis specification, embryo (GO:0008595)3.57157601
33detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.52910457
34melanin biosynthetic process (GO:0042438)3.48698179
35platelet dense granule organization (GO:0060155)3.41195544
36retinal rod cell development (GO:0046548)3.40777153
37regulation of type B pancreatic cell apoptotic process (GO:2000674)3.38817689
38regulation of appetite (GO:0032098)3.35641123
39cilium movement (GO:0003341)3.35390609
40mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.33635892
41histone mRNA catabolic process (GO:0071044)3.33602336
42negative regulation of muscle contraction (GO:0045932)3.30655606
43regulation of chronic inflammatory response (GO:0002676)3.30071014
44spinal cord development (GO:0021510)3.26906486
45estrogen biosynthetic process (GO:0006703)3.13282537
46cullin deneddylation (GO:0010388)3.13128246
47negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.10580238
48centriole replication (GO:0007099)3.09214757
49regulation of mitochondrial translation (GO:0070129)3.08713907
50histone mRNA metabolic process (GO:0008334)3.08157183
51ubiquinone biosynthetic process (GO:0006744)3.06023833
52peptidyl-histidine modification (GO:0018202)3.03464626
53melanin metabolic process (GO:0006582)3.02919427
54cilium organization (GO:0044782)3.00433941
55limb bud formation (GO:0060174)2.96466565
56detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)2.93683538
57energy coupled proton transport, down electrochemical gradient (GO:0015985)2.92376089
58ATP synthesis coupled proton transport (GO:0015986)2.92376089
59response to gravity (GO:0009629)2.91935544
60heparin metabolic process (GO:0030202)2.91314672
61heparin biosynthetic process (GO:0030210)2.91314672
62protein deneddylation (GO:0000338)2.89480778
63viral mRNA export from host cell nucleus (GO:0046784)2.89446730
64negative regulation of hormone biosynthetic process (GO:0032353)2.88206658
65axoneme assembly (GO:0035082)2.85841779
66detection of chemical stimulus involved in sensory perception of taste (GO:0050912)2.85221731
67startle response (GO:0001964)2.81228728
68inner ear receptor stereocilium organization (GO:0060122)2.80846387
69replication fork processing (GO:0031297)2.79939560
70ubiquinone metabolic process (GO:0006743)2.78136410
71sensory perception of smell (GO:0007608)2.77783011
72protein K63-linked deubiquitination (GO:0070536)2.74615767
73lateral sprouting from an epithelium (GO:0060601)2.73751315
74Sertoli cell development (GO:0060009)2.72876859
75somatic hypermutation of immunoglobulin genes (GO:0016446)2.72613510
76somatic diversification of immune receptors via somatic mutation (GO:0002566)2.72613510
77negative regulation of neurotransmitter transport (GO:0051589)2.72250573
78centriole assembly (GO:0098534)2.71594002
79L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.70170663
80positive regulation of triglyceride biosynthetic process (GO:0010867)2.69227316
81negative regulation of execution phase of apoptosis (GO:1900118)2.67742342
82photoreceptor cell maintenance (GO:0045494)2.66259774
83intraciliary transport (GO:0042073)2.64040810
84cilium or flagellum-dependent cell motility (GO:0001539)2.61795321
85negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.60341517
86regulation of cilium movement (GO:0003352)2.58893479
87mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.57227498
88pancreas development (GO:0031016)2.56577124
89monocyte chemotaxis (GO:0002548)2.56559108
90ventricular system development (GO:0021591)2.56127207
91negative regulation of heart rate (GO:0010459)2.55640645
92forebrain morphogenesis (GO:0048853)2.54916123
93galactose catabolic process (GO:0019388)2.54132827
94auditory receptor cell stereocilium organization (GO:0060088)2.53158562
95cotranslational protein targeting to membrane (GO:0006613)2.52384066
96ribosomal small subunit assembly (GO:0000028)2.50970853
97translational termination (GO:0006415)2.50529988
98cilium assembly (GO:0042384)2.50395154
99hexose catabolic process (GO:0019320)2.50006481
100indolalkylamine catabolic process (GO:0046218)2.49439856

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GLI1_17442700_ChIP-ChIP_MESCs_Mouse5.45665263
2STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.26624026
3ZFP57_27257070_Chip-Seq_ESCs_Mouse2.65957151
4GABP_17652178_ChIP-ChIP_JURKAT_Human2.65200561
5POU3F2_20337985_ChIP-ChIP_501MEL_Human2.65017472
6VDR_22108803_ChIP-Seq_LS180_Human2.60168962
7GBX2_23144817_ChIP-Seq_PC3_Human2.58116480
8CTBP2_25329375_ChIP-Seq_LNCAP_Human2.44395632
9ELK1_19687146_ChIP-ChIP_HELA_Human2.43205620
10EWS_26573619_Chip-Seq_HEK293_Human2.38081522
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.36797593
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.33487892
13TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.28004915
14POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.28004915
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.25016120
16FUS_26573619_Chip-Seq_HEK293_Human2.15917833
17P300_19829295_ChIP-Seq_ESCs_Human2.14295299
18CTBP1_25329375_ChIP-Seq_LNCAP_Human2.06516976
19BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.01958325
20CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.01552589
21IGF1R_20145208_ChIP-Seq_DFB_Human1.96618634
22TAF15_26573619_Chip-Seq_HEK293_Human1.94310797
23CBX2_27304074_Chip-Seq_ESCs_Mouse1.92053093
24ZNF274_21170338_ChIP-Seq_K562_Hela1.84070774
25SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.77912510
26IRF1_19129219_ChIP-ChIP_H3396_Human1.77705331
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.71773451
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.70064581
29AR_21572438_ChIP-Seq_LNCaP_Human1.65887091
30TP53_16413492_ChIP-PET_HCT116_Human1.64985111
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.61384047
32ER_23166858_ChIP-Seq_MCF-7_Human1.59155023
33AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.58995484
34SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46305434
35E2F4_17652178_ChIP-ChIP_JURKAT_Human1.45692780
36NANOG_18555785_Chip-Seq_ESCs_Mouse1.43708634
37BCAT_22108803_ChIP-Seq_LS180_Human1.42886603
38STAT3_23295773_ChIP-Seq_U87_Human1.42756511
39SMAD3_21741376_ChIP-Seq_EPCs_Human1.42727766
40VDR_23849224_ChIP-Seq_CD4+_Human1.41299835
41MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.40914708
42SOX2_19829295_ChIP-Seq_ESCs_Human1.40831434
43NANOG_19829295_ChIP-Seq_ESCs_Human1.40831434
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38218924
45* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.38126334
46CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.36928843
47SMAD4_21799915_ChIP-Seq_A2780_Human1.36232828
48POU5F1_16153702_ChIP-ChIP_HESCs_Human1.36045144
49MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.35934347
50PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32911603
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32366072
52MYC_18940864_ChIP-ChIP_HL60_Human1.30332945
53HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.30167296
54FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.29143143
55RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.28827985
56AR_25329375_ChIP-Seq_VCAP_Human1.27287442
57CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.25494736
58KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.25121655
59ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.25045393
60SUZ12_27294783_Chip-Seq_NPCs_Mouse1.22700051
61PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.21397840
62OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21306417
63NOTCH1_21737748_ChIP-Seq_TLL_Human1.20233799
64EZH2_27294783_Chip-Seq_NPCs_Mouse1.17255519
65PCGF2_27294783_Chip-Seq_ESCs_Mouse1.16004020
66CBP_20019798_ChIP-Seq_JUKART_Human1.15582232
67IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.15582232
68TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.14938559
69EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.14754125
70TCF4_22108803_ChIP-Seq_LS180_Human1.14152239
71TP53_18474530_ChIP-ChIP_U2OS_Human1.13670926
72EGR1_23403033_ChIP-Seq_LIVER_Mouse1.11477717
73TP53_22573176_ChIP-Seq_HFKS_Human1.09948826
74TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06933814
75TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.06649649
76P53_22387025_ChIP-Seq_ESCs_Mouse1.05597332
77POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.05547561
78SOX2_16153702_ChIP-ChIP_HESCs_Human1.04457063
79NFE2_27457419_Chip-Seq_LIVER_Mouse1.03675884
80AR_20517297_ChIP-Seq_VCAP_Human1.03144110
81E2F1_18555785_Chip-Seq_ESCs_Mouse1.03078870
82NFYB_21822215_ChIP-Seq_K562_Human1.02326461
83CREB1_15753290_ChIP-ChIP_HEK293T_Human1.01489272
84FOXA1_21572438_ChIP-Seq_LNCaP_Human1.01076175
85SUZ12_18555785_Chip-Seq_ESCs_Mouse0.99630454
86HNFA_21074721_ChIP-Seq_CACO-2_Human0.99381984
87PADI4_21655091_ChIP-ChIP_MCF-7_Human0.99105017
88PHF8_20622853_ChIP-Seq_HELA_Human0.98695168
89JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.98348065
90PIAS1_25552417_ChIP-Seq_VCAP_Human0.98046395
91EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.97888489
92SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.97552110
93CBP_21632823_ChIP-Seq_H3396_Human0.96072796
94CDX2_22108803_ChIP-Seq_LS180_Human0.95980562
95P300_18555785_Chip-Seq_ESCs_Mouse0.95708655
96LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95114237
97TCF4_23295773_ChIP-Seq_U87_Human0.94938390
98SOX9_26525672_Chip-Seq_HEART_Mouse0.94714684
99ETV1_20927104_ChIP-Seq_GIST48_Human0.94357702
100SRF_21415370_ChIP-Seq_HL-1_Mouse0.94173630

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002938_white_spotting4.40472788
2MP0003283_abnormal_digestive_organ3.80777363
3MP0000372_irregular_coat_pigmentation3.71520748
4MP0005171_absent_coat_pigmentation3.32726731
5MP0004147_increased_porphyrin_level3.28993014
6MP0005408_hypopigmentation3.15986700
7MP0005075_abnormal_melanosome_morpholog3.03046723
8MP0003890_abnormal_embryonic-extraembry2.91358378
9MP0002095_abnormal_skin_pigmentation2.68051072
10MP0002653_abnormal_ependyma_morphology2.64188126
11MP0004381_abnormal_hair_follicle2.63439417
12MP0009697_abnormal_copulation2.49359344
13MP0003880_abnormal_central_pattern2.40054850
14MP0002254_reproductive_system_inflammat2.07590667
15MP0002638_abnormal_pupillary_reflex2.05433753
16MP0003136_yellow_coat_color11.4907745
17MP0000569_abnormal_digit_pigmentation1.76223583
18MP0006292_abnormal_olfactory_placode1.71025024
19MP0001984_abnormal_olfaction1.67757146
20MP0004133_heterotaxia1.61851589
21MP0010030_abnormal_orbit_morphology1.56786237
22MP0001324_abnormal_eye_pigmentation1.37255533
23MP0008058_abnormal_DNA_repair1.32031812
24MP0005646_abnormal_pituitary_gland1.29586248
25MP0001529_abnormal_vocalization1.23861591
26MP0003045_fibrosis1.22187751
27MP0000631_abnormal_neuroendocrine_gland1.19295956
28MP0002751_abnormal_autonomic_nervous1.13838099
29MP0001186_pigmentation_phenotype1.12874836
30MP0003943_abnormal_hepatobiliary_system1.12323748
31MP0005174_abnormal_tail_pigmentation1.12217566
32MP0006072_abnormal_retinal_apoptosis1.12059547
33MP0002075_abnormal_coat/hair_pigmentati1.11303188
34MP0005253_abnormal_eye_physiology1.09372515
35MP0005551_abnormal_eye_electrophysiolog1.05549061
36MP0002282_abnormal_trachea_morphology1.04747122
37MP0003011_delayed_dark_adaptation1.04192414
38MP0002277_abnormal_respiratory_mucosa1.00980902
39MP0003122_maternal_imprinting0.97391899
40MP0010386_abnormal_urinary_bladder0.94850372
41MP0000026_abnormal_inner_ear0.92524857
42MP0000566_synostosis0.91745354
43MP0008875_abnormal_xenobiotic_pharmacok0.91396648
44MP0000371_diluted_coat_color0.91390914
45MP0000049_abnormal_middle_ear0.89189552
46MP0003806_abnormal_nucleotide_metabolis0.88439776
47MP0004142_abnormal_muscle_tone0.85054031
48MP0004885_abnormal_endolymph0.85052425
49MP0008877_abnormal_DNA_methylation0.83282869
50MP0003937_abnormal_limbs/digits/tail_de0.81900668
51MP0003646_muscle_fatigue0.80279989
52MP0005645_abnormal_hypothalamus_physiol0.79771282
53MP0006276_abnormal_autonomic_nervous0.75991637
54MP0008995_early_reproductive_senescence0.75578530
55MP0002876_abnormal_thyroid_physiology0.75271649
56MP0003938_abnormal_ear_development0.72221779
57MP0005257_abnormal_intraocular_pressure0.70200279
58MP0008932_abnormal_embryonic_tissue0.69915199
59MP0002090_abnormal_vision0.69875500
60MP0001764_abnormal_homeostasis0.69098970
61MP0000639_abnormal_adrenal_gland0.68846253
62MP0003195_calcinosis0.68824965
63MP0003121_genomic_imprinting0.68404327
64MP0006036_abnormal_mitochondrial_physio0.66073256
65MP0002736_abnormal_nociception_after0.64977523
66MP0000749_muscle_degeneration0.62000928
67MP0000343_altered_response_to0.61280433
68MP0001963_abnormal_hearing_physiology0.60743104
69MP0005389_reproductive_system_phenotype0.59769421
70MP0002160_abnormal_reproductive_system0.58029659
71MP0002752_abnormal_somatic_nervous0.57495721
72MP0001346_abnormal_lacrimal_gland0.56061450
73MP0005391_vision/eye_phenotype0.55889530
74MP0004043_abnormal_pH_regulation0.55866921
75MP0004145_abnormal_muscle_electrophysio0.55557209
76MP0005083_abnormal_biliary_tract0.55544617
77MP0000015_abnormal_ear_pigmentation0.55067529
78MP0002233_abnormal_nose_morphology0.53854918
79MP0010329_abnormal_lipoprotein_level0.52743631
80MP0003252_abnormal_bile_duct0.52555042
81MP0001485_abnormal_pinna_reflex0.52460739
82MP0005636_abnormal_mineral_homeostasis0.52433722
83MP0010307_abnormal_tumor_latency0.52115896
84MP0003119_abnormal_digestive_system0.51267131
85MP0001919_abnormal_reproductive_system0.50723130
86MP0008789_abnormal_olfactory_epithelium0.50146178
87MP0004742_abnormal_vestibular_system0.49831053
88MP0008007_abnormal_cellular_replicative0.49606941
89MP0001119_abnormal_female_reproductive0.48939492
90MP0000762_abnormal_tongue_morphology0.48217990
91MP0000778_abnormal_nervous_system0.46831209
92MP0005423_abnormal_somatic_nervous0.46760310
93MP0002295_abnormal_pulmonary_circulatio0.42792927
94MP0001286_abnormal_eye_development0.42536467
95MP0009046_muscle_twitch0.42505326
96MP0003787_abnormal_imprinting0.42415807
97MP0001905_abnormal_dopamine_level0.42351800
98MP0004085_abnormal_heartbeat0.40828162
99MP0001486_abnormal_startle_reflex0.40653463
100MP0003755_abnormal_palate_morphology0.40435344

Predicted human phenotypes

RankGene SetZ-score
1Entropion (HP:0000621)6.87550762
2Abnormality of DNA repair (HP:0003254)6.77750112
3Poikiloderma (HP:0001029)5.66411111
4True hermaphroditism (HP:0010459)5.17892946
5Pancreatic cysts (HP:0001737)4.92677575
6Pancreatic fibrosis (HP:0100732)4.41473860
7Type I transferrin isoform profile (HP:0003642)4.10182528
8Cystic liver disease (HP:0006706)3.71686334
9Reduced antithrombin III activity (HP:0001976)3.56219223
10Hyperinsulinemic hypoglycemia (HP:0000825)3.46926718
11Ectropion (HP:0000656)3.26838639
12Aplasia/Hypoplasia of the tongue (HP:0010295)3.24789762
13Sclerocornea (HP:0000647)3.18205510
14Occipital encephalocele (HP:0002085)3.16429131
15Anencephaly (HP:0002323)3.05358969
16Abnormality of the labia minora (HP:0012880)3.04790472
17Molar tooth sign on MRI (HP:0002419)2.98486097
18Abnormality of midbrain morphology (HP:0002418)2.98486097
19Degeneration of anterior horn cells (HP:0002398)2.93741119
20Abnormality of the anterior horn cell (HP:0006802)2.93741119
21Esophageal atresia (HP:0002032)2.87918608
22Aplasia/Hypoplasia of the uvula (HP:0010293)2.83224960
23Abnormality of the ileum (HP:0001549)2.69351947
24Congenital hepatic fibrosis (HP:0002612)2.65312684
25Bifid tongue (HP:0010297)2.65263883
26Meckel diverticulum (HP:0002245)2.63632209
27Neuroendocrine neoplasm (HP:0100634)2.63057505
28Hypoplasia of the fovea (HP:0007750)2.62829982
29Aplasia/Hypoplasia of the fovea (HP:0008060)2.62829982
30Squamous cell carcinoma (HP:0002860)2.61286958
31Male pseudohermaphroditism (HP:0000037)2.55957204
32Gonadotropin excess (HP:0000837)2.55141736
33Posterior subcapsular cataract (HP:0007787)2.55014571
34Aqueductal stenosis (HP:0002410)2.54364795
35Abnormal glycosylation (HP:0012345)2.52458187
36Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.52458187
37Abnormal protein N-linked glycosylation (HP:0012347)2.52458187
38Abnormal protein glycosylation (HP:0012346)2.52458187
39Abnormality of the pons (HP:0007361)2.50667666
40Basal cell carcinoma (HP:0002671)2.47276828
41Decreased central vision (HP:0007663)2.45700226
42Abnormality of chromosome stability (HP:0003220)2.44829586
43Keratoconus (HP:0000563)2.41756856
44Increased corneal curvature (HP:0100692)2.41756856
45Increased hepatocellular lipid droplets (HP:0006565)2.33636966
46Oligohydramnios (HP:0001562)2.32487568
47Gastrointestinal atresia (HP:0002589)2.25912767
48Medial flaring of the eyebrow (HP:0010747)2.25531873
49Sensorimotor neuropathy (HP:0007141)2.24089733
50Lipid accumulation in hepatocytes (HP:0006561)2.23265698
51Pheochromocytoma (HP:0002666)2.21736992
52Mitochondrial inheritance (HP:0001427)2.17539821
53Acute necrotizing encephalopathy (HP:0006965)2.15247564
54Hyperglycinuria (HP:0003108)2.13304852
55Renal Fanconi syndrome (HP:0001994)2.13214214
56Postaxial foot polydactyly (HP:0001830)2.12684837
57Hypoplasia of the pons (HP:0012110)2.10535046
58Abnormality of the preputium (HP:0100587)2.10027326
59Decreased electroretinogram (ERG) amplitude (HP:0000654)2.09907234
60Furrowed tongue (HP:0000221)2.06850403
61Abnormal number of erythroid precursors (HP:0012131)2.06661080
62Abnormality of lateral ventricle (HP:0030047)2.05926107
63Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.04049165
64Vertebral hypoplasia (HP:0008417)2.04049165
65Myelomeningocele (HP:0002475)2.02666568
66Nephronophthisis (HP:0000090)2.02564939
67Absent thumb (HP:0009777)1.99119247
68Aplasia involving bones of the upper limbs (HP:0009823)1.98615152
69Aplasia of the phalanges of the hand (HP:0009802)1.98615152
70Aplasia involving bones of the extremities (HP:0009825)1.98615152
71Patchy hypopigmentation of hair (HP:0011365)1.98469025
72Hypoplastic pelvis (HP:0008839)1.98398459
73Axonal loss (HP:0003447)1.96833718
74Sloping forehead (HP:0000340)1.96411567
75Adrenal hypoplasia (HP:0000835)1.95686462
76Increased CSF lactate (HP:0002490)1.95651197
77Abnormality of the renal medulla (HP:0100957)1.93937271
78Septo-optic dysplasia (HP:0100842)1.93916892
79Abnormality of the fovea (HP:0000493)1.93499718
80Preaxial hand polydactyly (HP:0001177)1.91805000
81Keratitis (HP:0000491)1.91152914
82Reticulocytopenia (HP:0001896)1.91066265
83Abnormality of the phalanges of the 2nd finger (HP:0009541)1.89823646
84Absent septum pellucidum (HP:0001331)1.88559025
85Aganglionic megacolon (HP:0002251)1.88293496
86Progressive macrocephaly (HP:0004481)1.84673396
87Acute encephalopathy (HP:0006846)1.84498465
88Oculomotor apraxia (HP:0000657)1.83255078
89Clubbing of toes (HP:0100760)1.79470792
90Abnormal mitochondria in muscle tissue (HP:0008316)1.79022911
91Decreased lacrimation (HP:0000633)1.77652164
92Triphalangeal thumb (HP:0001199)1.77280814
93Astigmatism (HP:0000483)1.76370869
94Neoplasm of the oral cavity (HP:0100649)1.75504774
95Postaxial hand polydactyly (HP:0001162)1.75401671
96Congenital sensorineural hearing impairment (HP:0008527)1.73212657
97Meningocele (HP:0002435)1.72844740
98Congenital primary aphakia (HP:0007707)1.72139767
99Glioma (HP:0009733)1.71930953
100White forelock (HP:0002211)1.71232764

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK5.81345932
2TSSK65.41476749
3WEE14.04242879
4TNIK3.88281940
5ACVR1B3.02381695
6BMPR1B2.98773125
7TAOK32.36276483
8NTRK32.15697485
9FGFR22.14972357
10MAP3K122.12616083
11EPHA42.00110991
12MAPK151.78877861
13FRK1.75070688
14WNK31.56921016
15BRSK21.47666951
16AKT31.45820130
17CCNB11.40902392
18TGFBR11.34913495
19DYRK31.30598842
20MKNK21.27665181
21BCKDK1.17748322
22GRK11.16157410
23MST41.14730514
24TXK1.14586388
25CSNK1G11.13871025
26MAP4K21.11978749
27WNK11.07527003
28INSRR1.07287897
29CSNK1G31.05038873
30ADRBK11.04573947
31PINK11.04080016
32TLK11.03700198
33CSNK1A1L0.98029716
34PLK20.92325942
35WNK40.88455572
36MKNK10.86470811
37CSNK1G20.85833030
38IRAK40.81806145
39VRK10.81622119
40NLK0.81613380
41IKBKB0.80065458
42BRD40.75673338
43OXSR10.74739279
44ADRBK20.73373582
45IKBKE0.72906407
46CDK190.71641111
47SGK2230.68750133
48SGK4940.68750133
49IRAK10.68351186
50MAPK130.68216338
51BRSK10.67076245
52PRKCE0.63074688
53ERBB30.62779429
54SGK20.61504223
55CAMK2D0.60733529
56MAPKAPK30.60523167
57CAMK2G0.59680983
58CASK0.59629309
59PRKCG0.58026080
60PLK30.56897566
61BMPR20.56167362
62CSNK2A20.55641680
63PIM20.54854796
64PDK20.54588987
65DAPK20.54391380
66CDK70.54210196
67TYRO30.52129801
68PRKCQ0.51310522
69CSNK1A10.51173576
70CHUK0.48891287
71IRAK20.47911332
72FGFR10.47745892
73AURKB0.47230014
74TRIM280.45782566
75PIK3CG0.45667241
76PRKCI0.45564832
77PASK0.45044433
78CAMK2B0.44669728
79PKN10.44371061
80ATR0.43234795
81CAMKK20.39608183
82PTK60.39549546
83NEK60.39406307
84RPS6KA40.39116361
85GRK70.38475401
86PLK10.37731083
87ZAK0.37171886
88PIK3CA0.36609872
89ABL20.35605053
90STK100.35482883
91TIE10.35454835
92ATM0.34557587
93BLK0.34306733
94PRKACA0.33097430
95TYK20.32912811
96MAPK100.31879088
97PRKG10.29187468
98CDK30.28718010
99MAPK70.28631343
100CSNK2A10.28319685

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006014.54415325
2Protein export_Homo sapiens_hsa030603.67344337
3Oxidative phosphorylation_Homo sapiens_hsa001903.14132653
4Ribosome_Homo sapiens_hsa030103.07802678
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.07498763
6Folate biosynthesis_Homo sapiens_hsa007902.82515727
7Proteasome_Homo sapiens_hsa030502.75998784
8Nucleotide excision repair_Homo sapiens_hsa034202.46757647
9Homologous recombination_Homo sapiens_hsa034402.45922594
10Parkinsons disease_Homo sapiens_hsa050122.43507079
11Fanconi anemia pathway_Homo sapiens_hsa034602.22997976
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.20724471
13Huntingtons disease_Homo sapiens_hsa050162.10887913
14Butanoate metabolism_Homo sapiens_hsa006502.09530491
15Fatty acid elongation_Homo sapiens_hsa000621.75986515
16Tryptophan metabolism_Homo sapiens_hsa003801.75619304
17Steroid biosynthesis_Homo sapiens_hsa001001.74892170
18Maturity onset diabetes of the young_Homo sapiens_hsa049501.70766893
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.66658742
20Nitrogen metabolism_Homo sapiens_hsa009101.60180363
21Sulfur relay system_Homo sapiens_hsa041221.53152753
22Alzheimers disease_Homo sapiens_hsa050101.37584520
23Phototransduction_Homo sapiens_hsa047441.35389610
24Basal cell carcinoma_Homo sapiens_hsa052171.35335783
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.25285367
26Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.19683820
27Olfactory transduction_Homo sapiens_hsa047401.18999184
28Propanoate metabolism_Homo sapiens_hsa006401.12370837
29Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.11870839
30ABC transporters_Homo sapiens_hsa020101.10451429
31Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.09788513
32RNA degradation_Homo sapiens_hsa030181.08956142
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.06311835
34Spliceosome_Homo sapiens_hsa030401.06181727
35Cardiac muscle contraction_Homo sapiens_hsa042601.05999310
36beta-Alanine metabolism_Homo sapiens_hsa004101.05571636
37Mismatch repair_Homo sapiens_hsa034301.05439568
38Peroxisome_Homo sapiens_hsa041461.01598221
39Purine metabolism_Homo sapiens_hsa002301.00002521
40Antigen processing and presentation_Homo sapiens_hsa046120.96639437
41NOD-like receptor signaling pathway_Homo sapiens_hsa046210.94880469
42Fatty acid degradation_Homo sapiens_hsa000710.90918394
43Histidine metabolism_Homo sapiens_hsa003400.88871502
44Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.88680902
45Steroid hormone biosynthesis_Homo sapiens_hsa001400.87459213
46Mineral absorption_Homo sapiens_hsa049780.86190168
47Taste transduction_Homo sapiens_hsa047420.84935644
48RNA polymerase_Homo sapiens_hsa030200.82895531
49Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.80817927
50Pyruvate metabolism_Homo sapiens_hsa006200.79626976
51Linoleic acid metabolism_Homo sapiens_hsa005910.78508262
52N-Glycan biosynthesis_Homo sapiens_hsa005100.77178568
53Non-homologous end-joining_Homo sapiens_hsa034500.77091810
54Regulation of autophagy_Homo sapiens_hsa041400.76626808
55Metabolic pathways_Homo sapiens_hsa011000.76302298
56Glutathione metabolism_Homo sapiens_hsa004800.76066904
57Sulfur metabolism_Homo sapiens_hsa009200.73040962
58Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.72289926
59Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.70739720
60Chemical carcinogenesis_Homo sapiens_hsa052040.69178414
61Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.68531694
62TGF-beta signaling pathway_Homo sapiens_hsa043500.66224048
63Legionellosis_Homo sapiens_hsa051340.65901314
64Basal transcription factors_Homo sapiens_hsa030220.65639986
65Fatty acid metabolism_Homo sapiens_hsa012120.65460149
66Glycerolipid metabolism_Homo sapiens_hsa005610.64139676
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62727200
68p53 signaling pathway_Homo sapiens_hsa041150.62479990
69RNA transport_Homo sapiens_hsa030130.62042374
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57430877
71Asthma_Homo sapiens_hsa053100.57408085
72Primary bile acid biosynthesis_Homo sapiens_hsa001200.56812926
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56619704
74Thyroid cancer_Homo sapiens_hsa052160.53739785
75Arginine and proline metabolism_Homo sapiens_hsa003300.53527969
76Fatty acid biosynthesis_Homo sapiens_hsa000610.52816628
77Cyanoamino acid metabolism_Homo sapiens_hsa004600.52157583
78Base excision repair_Homo sapiens_hsa034100.51843282
79Prion diseases_Homo sapiens_hsa050200.50766817
80Rheumatoid arthritis_Homo sapiens_hsa053230.50533423
81alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.49144403
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49072561
83Cysteine and methionine metabolism_Homo sapiens_hsa002700.44036322
84Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.44019355
85Circadian rhythm_Homo sapiens_hsa047100.41955996
86Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.41307649
87Wnt signaling pathway_Homo sapiens_hsa043100.40348553
88Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.38867030
89Retinol metabolism_Homo sapiens_hsa008300.38619246
90Pyrimidine metabolism_Homo sapiens_hsa002400.37557398
91Ether lipid metabolism_Homo sapiens_hsa005650.37362046
92Type I diabetes mellitus_Homo sapiens_hsa049400.34691865
93mRNA surveillance pathway_Homo sapiens_hsa030150.33992196
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.32882339
95Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.32045994
96Melanogenesis_Homo sapiens_hsa049160.31941900
97Caffeine metabolism_Homo sapiens_hsa002320.30806300
98Prostate cancer_Homo sapiens_hsa052150.29709987
99Arachidonic acid metabolism_Homo sapiens_hsa005900.29327770
100Hippo signaling pathway_Homo sapiens_hsa043900.27793716

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