CYCSP55

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maturation of 5.8S rRNA (GO:0000460)5.68846330
2proteasome assembly (GO:0043248)5.48805979
3L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.94299972
4synapsis (GO:0007129)4.68070248
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.52134943
6DNA deamination (GO:0045006)4.45245914
7peptidyl-histidine modification (GO:0018202)4.41468292
8chaperone-mediated protein transport (GO:0072321)4.30304466
9respiratory chain complex IV assembly (GO:0008535)4.28143109
10ATP synthesis coupled proton transport (GO:0015986)4.21870901
11energy coupled proton transport, down electrochemical gradient (GO:0015985)4.21870901
12negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.20994289
13positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.11195906
14regulation of cellular amino acid metabolic process (GO:0006521)4.10773578
15exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 4.10667161
16mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.09362068
17nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)4.07226020
18L-methionine salvage (GO:0071267)4.03448207
19L-methionine biosynthetic process (GO:0071265)4.03448207
20amino acid salvage (GO:0043102)4.03448207
21regulation of DNA endoreduplication (GO:0032875)4.03081031
22mitochondrial respiratory chain complex assembly (GO:0033108)4.01018781
23mitochondrial respiratory chain complex I assembly (GO:0032981)3.97939511
24NADH dehydrogenase complex assembly (GO:0010257)3.97939511
25mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.97939511
26DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.97381214
27regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.97365080
28protein complex biogenesis (GO:0070271)3.91612879
29rRNA catabolic process (GO:0016075)3.89765935
30respiratory electron transport chain (GO:0022904)3.89595425
31intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.89376021
32signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.89376021
33negative regulation of heart rate (GO:0010459)3.87752501
34signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.86795642
35signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.86795642
36signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.86795642
37electron transport chain (GO:0022900)3.80857801
38anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.78872645
39negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.78260203
40negative regulation of ligase activity (GO:0051352)3.78260203
41establishment of protein localization to mitochondrial membrane (GO:0090151)3.69442879
42cullin deneddylation (GO:0010388)3.67904132
43signal transduction involved in DNA damage checkpoint (GO:0072422)3.66099558
44signal transduction involved in DNA integrity checkpoint (GO:0072401)3.66099558
45mature B cell differentiation involved in immune response (GO:0002313)3.64855750
46viral mRNA export from host cell nucleus (GO:0046784)3.63537027
47signal transduction involved in cell cycle checkpoint (GO:0072395)3.61077318
48positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.57366353
49anterograde synaptic vesicle transport (GO:0048490)3.56448023
50prenylation (GO:0097354)3.51747239
51protein prenylation (GO:0018342)3.51747239
52oxidative phosphorylation (GO:0006119)3.50122132
53histone mRNA metabolic process (GO:0008334)3.48799732
54cytochrome complex assembly (GO:0017004)3.44718328
55positive regulation of ligase activity (GO:0051351)3.34355631
56DNA damage response, detection of DNA damage (GO:0042769)3.33959511
57tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.33850014
58RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.33850014
59organelle disassembly (GO:1903008)3.32273920
60rRNA modification (GO:0000154)3.32176456
61mature B cell differentiation (GO:0002335)3.30088663
62antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.27065383
63CENP-A containing nucleosome assembly (GO:0034080)3.25805274
64DNA catabolic process, exonucleolytic (GO:0000738)3.24762588
65antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.20848862
66terpenoid biosynthetic process (GO:0016114)3.20682783
67protein deneddylation (GO:0000338)3.19291489
68piRNA metabolic process (GO:0034587)3.19205945
69RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.18734275
70chromatin remodeling at centromere (GO:0031055)3.18286113
71rRNA methylation (GO:0031167)3.12340390
72protein K63-linked deubiquitination (GO:0070536)3.08780980
73termination of RNA polymerase III transcription (GO:0006386)3.07986001
74transcription elongation from RNA polymerase III promoter (GO:0006385)3.07986001
75regulation of ubiquitin-protein transferase activity (GO:0051438)3.04786230
76platelet dense granule organization (GO:0060155)2.99776308
77resolution of meiotic recombination intermediates (GO:0000712)2.97567725
78positive regulation of cell cycle arrest (GO:0071158)2.96791840
79methionine biosynthetic process (GO:0009086)2.96746346
80regulation of cellular amine metabolic process (GO:0033238)2.96346825
81histone exchange (GO:0043486)2.92658769
82hydrogen ion transmembrane transport (GO:1902600)2.90869664
83positive regulation of fibroblast migration (GO:0010763)2.90848719
84regulation of cellular respiration (GO:0043457)2.90781771
85protein targeting to mitochondrion (GO:0006626)2.89638903
86water-soluble vitamin biosynthetic process (GO:0042364)2.88192717
87preassembly of GPI anchor in ER membrane (GO:0016254)2.87679342
88regulation of ligase activity (GO:0051340)2.87673379
89rRNA processing (GO:0006364)2.87079463
90response to pheromone (GO:0019236)2.86260101
91cellular respiration (GO:0045333)2.86208730
92DNA double-strand break processing (GO:0000729)2.85416591
93DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.83167156
94methionine metabolic process (GO:0006555)2.82192179
95pseudouridine synthesis (GO:0001522)2.81120321
96negative regulation of protein ubiquitination (GO:0031397)2.81108173
97antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.78224401
98protein localization to mitochondrion (GO:0070585)2.78166323
99rRNA metabolic process (GO:0016072)2.77565175
100transcription from mitochondrial promoter (GO:0006390)2.77325537

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.71708373
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.10178022
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.96144211
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.65217249
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.53833250
6VDR_23849224_ChIP-Seq_CD4+_Human2.95781531
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.75876006
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.72911534
9ELK1_19687146_ChIP-ChIP_HELA_Human2.72223378
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.72105004
11VDR_22108803_ChIP-Seq_LS180_Human2.71918323
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.57868249
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.52517527
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.38994684
15PADI4_21655091_ChIP-ChIP_MCF-7_Human2.21974039
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.20904626
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.17252436
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.13674731
19FOXP3_21729870_ChIP-Seq_TREG_Human2.12922521
20FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.07232378
21ZNF274_21170338_ChIP-Seq_K562_Hela2.07222512
22FLI1_27457419_Chip-Seq_LIVER_Mouse2.02073274
23CREB1_15753290_ChIP-ChIP_HEK293T_Human1.97534754
24MYC_18555785_ChIP-Seq_MESCs_Mouse1.95042295
25POU3F2_20337985_ChIP-ChIP_501MEL_Human1.85861322
26PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.79068692
27EWS_26573619_Chip-Seq_HEK293_Human1.77151232
28IGF1R_20145208_ChIP-Seq_DFB_Human1.74213309
29ER_23166858_ChIP-Seq_MCF-7_Human1.55399951
30DCP1A_22483619_ChIP-Seq_HELA_Human1.55150024
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.53271073
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.47799031
33MYC_19030024_ChIP-ChIP_MESCs_Mouse1.47785687
34GABP_19822575_ChIP-Seq_HepG2_Human1.44221415
35P300_19829295_ChIP-Seq_ESCs_Human1.44184397
36SRF_21415370_ChIP-Seq_HL-1_Mouse1.42200784
37TP53_22573176_ChIP-Seq_HFKS_Human1.39524852
38CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.39255882
39GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.36629887
40HOXB4_20404135_ChIP-ChIP_EML_Mouse1.35768783
41FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.33711716
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.31777543
43TTF2_22483619_ChIP-Seq_HELA_Human1.31146670
44EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.31129366
45NANOG_19829295_ChIP-Seq_ESCs_Human1.30611886
46SOX2_19829295_ChIP-Seq_ESCs_Human1.30611886
47ZFP57_27257070_Chip-Seq_ESCs_Mouse1.30491889
48HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.30166097
49PCGF2_27294783_Chip-Seq_NPCs_Mouse1.30129342
50MYC_18358816_ChIP-ChIP_MESCs_Mouse1.29346039
51FUS_26573619_Chip-Seq_HEK293_Human1.28034916
52BCAT_22108803_ChIP-Seq_LS180_Human1.27371546
53MYC_18940864_ChIP-ChIP_HL60_Human1.26108366
54NFE2_27457419_Chip-Seq_LIVER_Mouse1.25428348
55SUZ12_27294783_Chip-Seq_NPCs_Mouse1.23674384
56YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22947960
57EZH2_27294783_Chip-Seq_NPCs_Mouse1.21352989
58PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.20469374
59PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.17296020
60POU5F1_16153702_ChIP-ChIP_HESCs_Human1.15216006
61FOXH1_21741376_ChIP-Seq_EPCs_Human1.14917082
62HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.13914005
63NOTCH1_21737748_ChIP-Seq_TLL_Human1.13484197
64KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.12533531
65EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.12434042
66SALL1_21062744_ChIP-ChIP_HESCs_Human1.11811355
67HOXB7_26014856_ChIP-Seq_BT474_Human1.10704306
68IRF8_21731497_ChIP-ChIP_J774_Mouse1.09781927
69E2F7_22180533_ChIP-Seq_HELA_Human1.09402627
70E2F1_18555785_ChIP-Seq_MESCs_Mouse1.09295923
71KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08143365
72ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.07559579
73CRX_20693478_ChIP-Seq_RETINA_Mouse1.07532704
74TCF4_22108803_ChIP-Seq_LS180_Human1.06904763
75IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.04068204
76NCOR_22424771_ChIP-Seq_293T_Human1.03493028
77GATA3_26560356_Chip-Seq_TH2_Human1.03017003
78FOXA1_25329375_ChIP-Seq_VCAP_Human1.00677313
79FOXA1_27270436_Chip-Seq_PROSTATE_Human1.00677313
80AR_20517297_ChIP-Seq_VCAP_Human0.99969896
81TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99314334
82UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99038834
83CBP_20019798_ChIP-Seq_JUKART_Human0.98612885
84IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98612885
85CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.97767450
86STAT3_18555785_Chip-Seq_ESCs_Mouse0.97024264
87CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.95972017
88OCT4_18555785_Chip-Seq_ESCs_Mouse0.95644905
89RBPJ_21746931_ChIP-Seq_IB4_Human0.94685817
90P300_18555785_Chip-Seq_ESCs_Mouse0.94559478
91SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.94362037
92PHF8_20622853_ChIP-Seq_HELA_Human0.94125096
93CDX2_22108803_ChIP-Seq_LS180_Human0.93747164
94AUTS2_25519132_ChIP-Seq_293T-REX_Human0.93473314
95RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.93418813
96FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.92986663
97CIITA_25753668_ChIP-Seq_RAJI_Human0.91781343
98MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.89725368
99CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.88408767
100EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.88216389

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose3.74762814
2MP0002102_abnormal_ear_morphology3.38403406
3MP0003646_muscle_fatigue3.04636115
4MP0006036_abnormal_mitochondrial_physio3.00154528
5MP0001835_abnormal_antigen_presentation2.73830620
6MP0005645_abnormal_hypothalamus_physiol2.68205760
7MP0006292_abnormal_olfactory_placode2.43177714
8MP0005075_abnormal_melanosome_morpholog2.33841851
9MP0006035_abnormal_mitochondrial_morpho2.29653224
10MP0003718_maternal_effect2.16652192
11MP0005084_abnormal_gallbladder_morpholo2.15689425
12MP0005646_abnormal_pituitary_gland2.12093398
13MP0002837_dystrophic_cardiac_calcinosis2.07184742
14MP0000372_irregular_coat_pigmentation2.06709049
15MP0001986_abnormal_taste_sensitivity2.05358584
16MP0008058_abnormal_DNA_repair1.99191798
17MP0004147_increased_porphyrin_level1.93442438
18MP0000516_abnormal_urinary_system1.93316848
19MP0005367_renal/urinary_system_phenotyp1.93316848
20MP0004142_abnormal_muscle_tone1.87173352
21MP0003786_premature_aging1.83340899
22MP0003806_abnormal_nucleotide_metabolis1.76847177
23MP0004885_abnormal_endolymph1.68547691
24MP0010094_abnormal_chromosome_stability1.68119748
25MP0002090_abnormal_vision1.60404278
26MP0004134_abnormal_chest_morphology1.56069310
27MP0003693_abnormal_embryo_hatching1.55036072
28MP0004957_abnormal_blastocyst_morpholog1.52656992
29MP0008877_abnormal_DNA_methylation1.52188386
30MP0003186_abnormal_redox_activity1.47454566
31MP0008872_abnormal_physiological_respon1.46262687
32MP0001486_abnormal_startle_reflex1.46009059
33MP0003195_calcinosis1.45174654
34MP0005551_abnormal_eye_electrophysiolog1.44255272
35MP0002751_abnormal_autonomic_nervous1.42453762
36MP0005174_abnormal_tail_pigmentation1.40907086
37MP0001661_extended_life_span1.39893045
38MP0008057_abnormal_DNA_replication1.38278715
39MP0003950_abnormal_plasma_membrane1.35359892
40MP0001529_abnormal_vocalization1.32497294
41MP0001968_abnormal_touch/_nociception1.30284105
42MP0002822_catalepsy1.29455400
43MP0002163_abnormal_gland_morphology1.28631971
44MP0005332_abnormal_amino_acid1.28423300
45MP0001800_abnormal_humoral_immune1.26838909
46MP0002210_abnormal_sex_determination1.23539843
47MP0005408_hypopigmentation1.23154168
48MP0002736_abnormal_nociception_after1.20367626
49MP0001929_abnormal_gametogenesis1.17180670
50MP0006072_abnormal_retinal_apoptosis1.16726854
51MP0004215_abnormal_myocardial_fiber1.15998436
52MP0002166_altered_tumor_susceptibility1.14700880
53MP0005379_endocrine/exocrine_gland_phen1.13740449
54MP0002148_abnormal_hypersensitivity_rea1.12984730
55MP0002160_abnormal_reproductive_system1.12725197
56MP0001293_anophthalmia1.12384426
57MP0008875_abnormal_xenobiotic_pharmacok1.08299915
58MP0001485_abnormal_pinna_reflex1.06991283
59MP0009697_abnormal_copulation1.04440118
60MP0003137_abnormal_impulse_conducting1.03299530
61MP0005253_abnormal_eye_physiology1.02010185
62MP0009745_abnormal_behavioral_response1.00852552
63MP0001440_abnormal_grooming_behavior1.00630673
64MP0004145_abnormal_muscle_electrophysio0.99623752
65MP0000427_abnormal_hair_cycle0.99394226
66MP0002272_abnormal_nervous_system0.98876761
67MP0001188_hyperpigmentation0.98438282
68MP0000653_abnormal_sex_gland0.98073152
69MP0004742_abnormal_vestibular_system0.97476802
70MP0001145_abnormal_male_reproductive0.93321293
71MP0001119_abnormal_female_reproductive0.90604537
72MP0005389_reproductive_system_phenotype0.90407621
73MP0002938_white_spotting0.90370599
74MP0005410_abnormal_fertilization0.89845978
75MP0002006_tumorigenesis0.88218831
76MP0002396_abnormal_hematopoietic_system0.87556665
77MP0005330_cardiomyopathy0.85141322
78MP0002452_abnormal_antigen_presenting0.83426860
79MP0002723_abnormal_immune_serum0.81661007
80MP0000685_abnormal_immune_system0.79407579
81MP0005671_abnormal_response_to0.76499894
82MP0009785_altered_susceptibility_to0.76256438
83MP0008961_abnormal_basal_metabolism0.75943919
84MP0002735_abnormal_chemical_nociception0.74802898
85MP0001984_abnormal_olfaction0.74746451
86MP0004484_altered_response_of0.74651656
87MP0009046_muscle_twitch0.74094506
88MP0000631_abnormal_neuroendocrine_gland0.73315005
89MP0003111_abnormal_nucleus_morphology0.72693768
90MP0000569_abnormal_digit_pigmentation0.71215720
91MP0004381_abnormal_hair_follicle0.70924126
92MP0003077_abnormal_cell_cycle0.70679297
93MP0001501_abnormal_sleep_pattern0.70100518
94MP0002095_abnormal_skin_pigmentation0.68430078
95MP0000647_abnormal_sebaceous_gland0.67870404
96MP0003866_abnormal_defecation0.66624319
97MP0000371_diluted_coat_color0.66441942
98MP0001756_abnormal_urination0.65255103
99MP0002876_abnormal_thyroid_physiology0.64444222
100MP0001970_abnormal_pain_threshold0.64299253

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.07273041
2Hepatocellular necrosis (HP:0001404)4.63134633
3Mitochondrial inheritance (HP:0001427)4.43246596
4Acute encephalopathy (HP:0006846)4.42585833
5Hepatic necrosis (HP:0002605)4.39074478
6Abnormal mitochondria in muscle tissue (HP:0008316)4.23556355
7Increased CSF lactate (HP:0002490)4.19715821
8Progressive macrocephaly (HP:0004481)4.16573148
9Cerebral edema (HP:0002181)4.13479599
103-Methylglutaconic aciduria (HP:0003535)3.63740391
11Cerebral hypomyelination (HP:0006808)3.33675575
12Abnormality of midbrain morphology (HP:0002418)3.29469502
13Molar tooth sign on MRI (HP:0002419)3.29469502
14Increased serum lactate (HP:0002151)3.25383431
15Decreased central vision (HP:0007663)3.23381389
16Increased hepatocellular lipid droplets (HP:0006565)3.15731281
17Congenital, generalized hypertrichosis (HP:0004540)2.98970140
18Congenital stationary night blindness (HP:0007642)2.91674914
19Respiratory failure (HP:0002878)2.85522091
20Lipid accumulation in hepatocytes (HP:0006561)2.83135171
21CNS demyelination (HP:0007305)2.79030459
22Elevated erythrocyte sedimentation rate (HP:0003565)2.77985563
23Leukodystrophy (HP:0002415)2.74912599
24Lactic acidosis (HP:0003128)2.73790525
25Degeneration of anterior horn cells (HP:0002398)2.71978833
26Abnormality of the anterior horn cell (HP:0006802)2.71978833
27Hyperglycinuria (HP:0003108)2.66085206
28Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.59978767
29Lethargy (HP:0001254)2.58475650
30Decreased electroretinogram (ERG) amplitude (HP:0000654)2.55687255
31Optic disc pallor (HP:0000543)2.55438218
32Renal Fanconi syndrome (HP:0001994)2.55387271
33Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.44149311
34Increased serum pyruvate (HP:0003542)2.43822996
35Constricted visual fields (HP:0001133)2.43603525
36Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.40428647
37Decreased activity of mitochondrial respiratory chain (HP:0008972)2.40428647
38Duplicated collecting system (HP:0000081)2.39116018
39Supernumerary spleens (HP:0009799)2.38272225
40Emotional lability (HP:0000712)2.36011388
41Abnormality of aspartate family amino acid metabolism (HP:0010899)2.33946809
42Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.31049143
43Abnormality of alanine metabolism (HP:0010916)2.31049143
44Hyperalaninemia (HP:0003348)2.31049143
45Abnormality of the pons (HP:0007361)2.29295150
46Abnormality of the renal cortex (HP:0011035)2.26343806
47Renal cortical cysts (HP:0000803)2.24690912
48Stomatitis (HP:0010280)2.23851557
49Generalized aminoaciduria (HP:0002909)2.22601413
50Abnormality of methionine metabolism (HP:0010901)2.21781633
51Abnormality of the renal collecting system (HP:0004742)2.20946160
52Hypothermia (HP:0002045)2.17446440
53Abolished electroretinogram (ERG) (HP:0000550)2.15707321
54Postnatal microcephaly (HP:0005484)2.13614868
55Spinal muscular atrophy (HP:0007269)2.10446094
56Hypoproteinemia (HP:0003075)2.10355999
57Exertional dyspnea (HP:0002875)2.07000768
58Exercise intolerance (HP:0003546)2.06920113
59Azoospermia (HP:0000027)2.05916525
60Methylmalonic acidemia (HP:0002912)2.04806477
61Chronic sinusitis (HP:0011109)2.02416168
62Abnormality of urine glucose concentration (HP:0011016)2.01500562
63Glycosuria (HP:0003076)2.01500562
64Large for gestational age (HP:0001520)2.01099865
65Abnormality of glycolysis (HP:0004366)2.00542975
66Tubular atrophy (HP:0000092)1.99629571
67Broad-based gait (HP:0002136)1.99150477
68Absent rod-and cone-mediated responses on ERG (HP:0007688)1.98628732
69Cone-rod dystrophy (HP:0000548)1.98015807
70Submucous cleft hard palate (HP:0000176)1.96917404
71Cleft eyelid (HP:0000625)1.96283805
72Clumsiness (HP:0002312)1.96235342
73Macular degeneration (HP:0000608)1.95416666
74Nephronophthisis (HP:0000090)1.95293468
75Abnormal rod and cone electroretinograms (HP:0008323)1.94862176
76CNS hypomyelination (HP:0003429)1.92595383
77Polydipsia (HP:0001959)1.92073086
78Abnormal drinking behavior (HP:0030082)1.92073086
79Aplasia/hypoplasia of the uterus (HP:0008684)1.91931754
80Papilledema (HP:0001085)1.90747952
81Pancreatic cysts (HP:0001737)1.88965252
82Median cleft lip (HP:0000161)1.86719402
83Progressive microcephaly (HP:0000253)1.84210583
84Oligodactyly (hands) (HP:0001180)1.83373984
85Methylmalonic aciduria (HP:0012120)1.81430078
86Muscular hypotonia of the trunk (HP:0008936)1.81321568
87Tongue fasciculations (HP:0001308)1.80867611
88Ureteral duplication (HP:0000073)1.80699721
89Adrenal hypoplasia (HP:0000835)1.80213513
90Abnormality of serum amino acid levels (HP:0003112)1.78880168
91Short tibia (HP:0005736)1.78272337
92Megaloblastic anemia (HP:0001889)1.78138848
93Abnormality of glycine metabolism (HP:0010895)1.77295333
94Abnormality of serine family amino acid metabolism (HP:0010894)1.77295333
95Atonic seizures (HP:0010819)1.77083519
96Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.75606004
97Degeneration of the lateral corticospinal tracts (HP:0002314)1.75606004
98Volvulus (HP:0002580)1.75277808
99Abnormality of the renal medulla (HP:0100957)1.74897277
100Delusions (HP:0000746)1.74651249

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK15.37610479
2MST44.98332720
3EIF2AK34.03791472
4BMPR23.35904937
5STK393.29261784
6OXSR12.91673507
7TSSK62.56179893
8PLK42.53017073
9VRK22.30153784
10NUAK11.97138856
11MAP3K121.91282917
12CCNB11.85119609
13BUB11.82479023
14WNK41.81521995
15MKNK21.72626048
16TRIM281.70554504
17NEK11.68275211
18CDK191.67176240
19STK38L1.57543844
20VRK11.52042655
21EIF2AK21.42535279
22PLK31.41939331
23PLK21.41880255
24ERBB31.39402604
25SRPK11.35676474
26TLK11.30322409
27TEC1.29925184
28CDC71.23471730
29ACVR1B1.17697220
30WNK31.17559945
31FRK1.17033913
32GRK11.14489778
33WEE11.13861354
34CSNK1A1L1.10428058
35BMPR1B1.08007217
36PDK21.00255121
37MYLK0.97746317
38MKNK10.93814079
39ADRBK20.93492251
40PLK10.88048665
41MAP2K60.87629576
42PHKG20.86017429
43PHKG10.86017429
44IKBKB0.85201158
45TNIK0.82465228
46CSNK1G30.82076175
47STK160.81681016
48TXK0.79154399
49NME20.76541498
50BRD40.75584891
51TYK20.74034051
52MAP4K20.73395364
53CSNK1G10.72767915
54ZAK0.70992556
55BCR0.70656938
56RPS6KA40.69618710
57STK30.68548415
58KIT0.68537147
59ILK0.67348461
60MAP3K40.66986610
61NME10.66450377
62PIK3CG0.65947891
63INSRR0.62158249
64ITK0.61128242
65AURKB0.56340582
66CSNK1G20.56308573
67PRKCE0.56215173
68CSF1R0.56019353
69GRK50.55178182
70ATR0.54958842
71STK40.49757669
72ABL20.47076950
73BCKDK0.45286266
74CSNK2A10.44676461
75CSNK2A20.42868143
76RIPK40.42570847
77DYRK30.42266954
78TRPM70.41797605
79PASK0.40164309
80EPHA40.39153315
81ERBB40.37827272
82PRKG10.37810473
83CHEK10.37316496
84SYK0.37247801
85PRKCG0.36153512
86ADRBK10.35448853
87CSNK1E0.34293446
88AKT20.34289284
89MAPKAPK50.33261733
90IGF1R0.32940729
91DAPK10.31793658
92MINK10.31502023
93CHUK0.31342092
94RPS6KA50.30484644
95FGFR10.30371118
96AKT30.29705709
97TAF10.29626444
98OBSCN0.28212426
99MAP2K70.27952121
100ATM0.25521884

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.08973214
2Asthma_Homo sapiens_hsa053103.59628579
3Oxidative phosphorylation_Homo sapiens_hsa001903.32710010
4Parkinsons disease_Homo sapiens_hsa050122.83200892
5Graft-versus-host disease_Homo sapiens_hsa053322.57257402
6Autoimmune thyroid disease_Homo sapiens_hsa053202.49557376
7Allograft rejection_Homo sapiens_hsa053302.48475648
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.47646680
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.38151809
10Sulfur metabolism_Homo sapiens_hsa009202.30308411
11Protein export_Homo sapiens_hsa030602.30302444
12RNA polymerase_Homo sapiens_hsa030202.19901939
13Type I diabetes mellitus_Homo sapiens_hsa049402.14577702
14Huntingtons disease_Homo sapiens_hsa050162.03424559
15RNA degradation_Homo sapiens_hsa030181.95529650
16Spliceosome_Homo sapiens_hsa030401.81975143
17Propanoate metabolism_Homo sapiens_hsa006401.78928049
18Basal transcription factors_Homo sapiens_hsa030221.70345804
19Alzheimers disease_Homo sapiens_hsa050101.70247527
20Homologous recombination_Homo sapiens_hsa034401.69016380
21One carbon pool by folate_Homo sapiens_hsa006701.65683139
22Mismatch repair_Homo sapiens_hsa034301.63686418
23Antigen processing and presentation_Homo sapiens_hsa046121.62865264
24RNA transport_Homo sapiens_hsa030131.62851367
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.60791668
26Linoleic acid metabolism_Homo sapiens_hsa005911.45598527
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.44982409
28Ribosome_Homo sapiens_hsa030101.42788786
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.42648981
30Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.38195034
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.35387958
32Rheumatoid arthritis_Homo sapiens_hsa053231.34909180
33Collecting duct acid secretion_Homo sapiens_hsa049661.30810857
34Viral myocarditis_Homo sapiens_hsa054161.24574090
35DNA replication_Homo sapiens_hsa030301.24423769
36Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.19764876
37Non-homologous end-joining_Homo sapiens_hsa034501.16012349
38Purine metabolism_Homo sapiens_hsa002301.14477912
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.13633424
40Phototransduction_Homo sapiens_hsa047441.11733743
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.05355570
42Cardiac muscle contraction_Homo sapiens_hsa042601.03711733
43Regulation of autophagy_Homo sapiens_hsa041401.01339765
44Nucleotide excision repair_Homo sapiens_hsa034201.00169982
45Pyrimidine metabolism_Homo sapiens_hsa002400.99854630
46beta-Alanine metabolism_Homo sapiens_hsa004100.94833005
47Fanconi anemia pathway_Homo sapiens_hsa034600.92117913
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.86415416
49Staphylococcus aureus infection_Homo sapiens_hsa051500.84157022
50Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.79886707
51Vitamin B6 metabolism_Homo sapiens_hsa007500.77793767
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.75661654
532-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.72614891
54Epstein-Barr virus infection_Homo sapiens_hsa051690.72194280
55Caffeine metabolism_Homo sapiens_hsa002320.71916346
56Herpes simplex infection_Homo sapiens_hsa051680.65157555
57Systemic lupus erythematosus_Homo sapiens_hsa053220.61082700
58Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.60736294
59Olfactory transduction_Homo sapiens_hsa047400.59912002
60Leishmaniasis_Homo sapiens_hsa051400.58990597
61Glutathione metabolism_Homo sapiens_hsa004800.57916931
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.57829795
63Fat digestion and absorption_Homo sapiens_hsa049750.56277665
64Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.54438586
65Selenocompound metabolism_Homo sapiens_hsa004500.54344019
66Ether lipid metabolism_Homo sapiens_hsa005650.51469254
67Legionellosis_Homo sapiens_hsa051340.50715969
68Arachidonic acid metabolism_Homo sapiens_hsa005900.49826738
69Peroxisome_Homo sapiens_hsa041460.49318149
70Pyruvate metabolism_Homo sapiens_hsa006200.48253316
71p53 signaling pathway_Homo sapiens_hsa041150.47091767
72Metabolic pathways_Homo sapiens_hsa011000.46548637
73NOD-like receptor signaling pathway_Homo sapiens_hsa046210.42417595
74Tryptophan metabolism_Homo sapiens_hsa003800.40215772
75Oocyte meiosis_Homo sapiens_hsa041140.38721405
76Primary immunodeficiency_Homo sapiens_hsa053400.38052855
77Cyanoamino acid metabolism_Homo sapiens_hsa004600.37203110
78Tuberculosis_Homo sapiens_hsa051520.37150911
79Nitrogen metabolism_Homo sapiens_hsa009100.36125013
80Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.35198910
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.35020603
82mRNA surveillance pathway_Homo sapiens_hsa030150.34418400
83Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34027548
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.33901761
85Taste transduction_Homo sapiens_hsa047420.33392688
86Cell cycle_Homo sapiens_hsa041100.33139680
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.28714022
88Arginine and proline metabolism_Homo sapiens_hsa003300.25341601
89Vibrio cholerae infection_Homo sapiens_hsa051100.24494892
90Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.23219505
91Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.22594307
92Shigellosis_Homo sapiens_hsa051310.21894740
93Chemical carcinogenesis_Homo sapiens_hsa052040.21676000
94Influenza A_Homo sapiens_hsa051640.21284157
95Phagosome_Homo sapiens_hsa041450.21117489
96Fatty acid metabolism_Homo sapiens_hsa012120.20964450
97Fatty acid elongation_Homo sapiens_hsa000620.19104593
98Butanoate metabolism_Homo sapiens_hsa006500.18424721
99Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.17968504
100Maturity onset diabetes of the young_Homo sapiens_hsa049500.17742689

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »