

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | maturation of 5.8S rRNA (GO:0000460) | 5.68846330 |
| 2 | proteasome assembly (GO:0043248) | 5.48805979 |
| 3 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 4.94299972 |
| 4 | synapsis (GO:0007129) | 4.68070248 |
| 5 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.52134943 |
| 6 | DNA deamination (GO:0045006) | 4.45245914 |
| 7 | peptidyl-histidine modification (GO:0018202) | 4.41468292 |
| 8 | chaperone-mediated protein transport (GO:0072321) | 4.30304466 |
| 9 | respiratory chain complex IV assembly (GO:0008535) | 4.28143109 |
| 10 | ATP synthesis coupled proton transport (GO:0015986) | 4.21870901 |
| 11 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.21870901 |
| 12 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.20994289 |
| 13 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 4.11195906 |
| 14 | regulation of cellular amino acid metabolic process (GO:0006521) | 4.10773578 |
| 15 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 4.10667161 |
| 16 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.09362068 |
| 17 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 4.07226020 |
| 18 | L-methionine salvage (GO:0071267) | 4.03448207 |
| 19 | L-methionine biosynthetic process (GO:0071265) | 4.03448207 |
| 20 | amino acid salvage (GO:0043102) | 4.03448207 |
| 21 | regulation of DNA endoreduplication (GO:0032875) | 4.03081031 |
| 22 | mitochondrial respiratory chain complex assembly (GO:0033108) | 4.01018781 |
| 23 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.97939511 |
| 24 | NADH dehydrogenase complex assembly (GO:0010257) | 3.97939511 |
| 25 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.97939511 |
| 26 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.97381214 |
| 27 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.97365080 |
| 28 | protein complex biogenesis (GO:0070271) | 3.91612879 |
| 29 | rRNA catabolic process (GO:0016075) | 3.89765935 |
| 30 | respiratory electron transport chain (GO:0022904) | 3.89595425 |
| 31 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.89376021 |
| 32 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.89376021 |
| 33 | negative regulation of heart rate (GO:0010459) | 3.87752501 |
| 34 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.86795642 |
| 35 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.86795642 |
| 36 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.86795642 |
| 37 | electron transport chain (GO:0022900) | 3.80857801 |
| 38 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.78872645 |
| 39 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.78260203 |
| 40 | negative regulation of ligase activity (GO:0051352) | 3.78260203 |
| 41 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.69442879 |
| 42 | cullin deneddylation (GO:0010388) | 3.67904132 |
| 43 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.66099558 |
| 44 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.66099558 |
| 45 | mature B cell differentiation involved in immune response (GO:0002313) | 3.64855750 |
| 46 | viral mRNA export from host cell nucleus (GO:0046784) | 3.63537027 |
| 47 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.61077318 |
| 48 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.57366353 |
| 49 | anterograde synaptic vesicle transport (GO:0048490) | 3.56448023 |
| 50 | prenylation (GO:0097354) | 3.51747239 |
| 51 | protein prenylation (GO:0018342) | 3.51747239 |
| 52 | oxidative phosphorylation (GO:0006119) | 3.50122132 |
| 53 | histone mRNA metabolic process (GO:0008334) | 3.48799732 |
| 54 | cytochrome complex assembly (GO:0017004) | 3.44718328 |
| 55 | positive regulation of ligase activity (GO:0051351) | 3.34355631 |
| 56 | DNA damage response, detection of DNA damage (GO:0042769) | 3.33959511 |
| 57 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.33850014 |
| 58 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.33850014 |
| 59 | organelle disassembly (GO:1903008) | 3.32273920 |
| 60 | rRNA modification (GO:0000154) | 3.32176456 |
| 61 | mature B cell differentiation (GO:0002335) | 3.30088663 |
| 62 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.27065383 |
| 63 | CENP-A containing nucleosome assembly (GO:0034080) | 3.25805274 |
| 64 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.24762588 |
| 65 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 3.20848862 |
| 66 | terpenoid biosynthetic process (GO:0016114) | 3.20682783 |
| 67 | protein deneddylation (GO:0000338) | 3.19291489 |
| 68 | piRNA metabolic process (GO:0034587) | 3.19205945 |
| 69 | RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) | 3.18734275 |
| 70 | chromatin remodeling at centromere (GO:0031055) | 3.18286113 |
| 71 | rRNA methylation (GO:0031167) | 3.12340390 |
| 72 | protein K63-linked deubiquitination (GO:0070536) | 3.08780980 |
| 73 | termination of RNA polymerase III transcription (GO:0006386) | 3.07986001 |
| 74 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.07986001 |
| 75 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.04786230 |
| 76 | platelet dense granule organization (GO:0060155) | 2.99776308 |
| 77 | resolution of meiotic recombination intermediates (GO:0000712) | 2.97567725 |
| 78 | positive regulation of cell cycle arrest (GO:0071158) | 2.96791840 |
| 79 | methionine biosynthetic process (GO:0009086) | 2.96746346 |
| 80 | regulation of cellular amine metabolic process (GO:0033238) | 2.96346825 |
| 81 | histone exchange (GO:0043486) | 2.92658769 |
| 82 | hydrogen ion transmembrane transport (GO:1902600) | 2.90869664 |
| 83 | positive regulation of fibroblast migration (GO:0010763) | 2.90848719 |
| 84 | regulation of cellular respiration (GO:0043457) | 2.90781771 |
| 85 | protein targeting to mitochondrion (GO:0006626) | 2.89638903 |
| 86 | water-soluble vitamin biosynthetic process (GO:0042364) | 2.88192717 |
| 87 | preassembly of GPI anchor in ER membrane (GO:0016254) | 2.87679342 |
| 88 | regulation of ligase activity (GO:0051340) | 2.87673379 |
| 89 | rRNA processing (GO:0006364) | 2.87079463 |
| 90 | response to pheromone (GO:0019236) | 2.86260101 |
| 91 | cellular respiration (GO:0045333) | 2.86208730 |
| 92 | DNA double-strand break processing (GO:0000729) | 2.85416591 |
| 93 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 2.83167156 |
| 94 | methionine metabolic process (GO:0006555) | 2.82192179 |
| 95 | pseudouridine synthesis (GO:0001522) | 2.81120321 |
| 96 | negative regulation of protein ubiquitination (GO:0031397) | 2.81108173 |
| 97 | antigen processing and presentation of peptide antigen via MHC class I (GO:0002474) | 2.78224401 |
| 98 | protein localization to mitochondrion (GO:0070585) | 2.78166323 |
| 99 | rRNA metabolic process (GO:0016072) | 2.77565175 |
| 100 | transcription from mitochondrial promoter (GO:0006390) | 2.77325537 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.71708373 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.10178022 |
| 3 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.96144211 |
| 4 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.65217249 |
| 5 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 3.53833250 |
| 6 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.95781531 |
| 7 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.75876006 |
| 8 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.72911534 |
| 9 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.72223378 |
| 10 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.72105004 |
| 11 | VDR_22108803_ChIP-Seq_LS180_Human | 2.71918323 |
| 12 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.57868249 |
| 13 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.52517527 |
| 14 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.38994684 |
| 15 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 2.21974039 |
| 16 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.20904626 |
| 17 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 2.17252436 |
| 18 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.13674731 |
| 19 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.12922521 |
| 20 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 2.07232378 |
| 21 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.07222512 |
| 22 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.02073274 |
| 23 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 1.97534754 |
| 24 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.95042295 |
| 25 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.85861322 |
| 26 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.79068692 |
| 27 | EWS_26573619_Chip-Seq_HEK293_Human | 1.77151232 |
| 28 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.74213309 |
| 29 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.55399951 |
| 30 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.55150024 |
| 31 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.53271073 |
| 32 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.47799031 |
| 33 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.47785687 |
| 34 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.44221415 |
| 35 | P300_19829295_ChIP-Seq_ESCs_Human | 1.44184397 |
| 36 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.42200784 |
| 37 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.39524852 |
| 38 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.39255882 |
| 39 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.36629887 |
| 40 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.35768783 |
| 41 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.33711716 |
| 42 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.31777543 |
| 43 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.31146670 |
| 44 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.31129366 |
| 45 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.30611886 |
| 46 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.30611886 |
| 47 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.30491889 |
| 48 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.30166097 |
| 49 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.30129342 |
| 50 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.29346039 |
| 51 | FUS_26573619_Chip-Seq_HEK293_Human | 1.28034916 |
| 52 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.27371546 |
| 53 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.26108366 |
| 54 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.25428348 |
| 55 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.23674384 |
| 56 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.22947960 |
| 57 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.21352989 |
| 58 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.20469374 |
| 59 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 1.17296020 |
| 60 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.15216006 |
| 61 | FOXH1_21741376_ChIP-Seq_EPCs_Human | 1.14917082 |
| 62 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.13914005 |
| 63 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.13484197 |
| 64 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.12533531 |
| 65 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.12434042 |
| 66 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.11811355 |
| 67 | HOXB7_26014856_ChIP-Seq_BT474_Human | 1.10704306 |
| 68 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 1.09781927 |
| 69 | E2F7_22180533_ChIP-Seq_HELA_Human | 1.09402627 |
| 70 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.09295923 |
| 71 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 1.08143365 |
| 72 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.07559579 |
| 73 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 1.07532704 |
| 74 | TCF4_22108803_ChIP-Seq_LS180_Human | 1.06904763 |
| 75 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.04068204 |
| 76 | NCOR_22424771_ChIP-Seq_293T_Human | 1.03493028 |
| 77 | GATA3_26560356_Chip-Seq_TH2_Human | 1.03017003 |
| 78 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.00677313 |
| 79 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.00677313 |
| 80 | AR_20517297_ChIP-Seq_VCAP_Human | 0.99969896 |
| 81 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.99314334 |
| 82 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 0.99038834 |
| 83 | CBP_20019798_ChIP-Seq_JUKART_Human | 0.98612885 |
| 84 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 0.98612885 |
| 85 | CEBPA_26348894_ChIP-Seq_LIVER_Mouse | 0.97767450 |
| 86 | STAT3_18555785_Chip-Seq_ESCs_Mouse | 0.97024264 |
| 87 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 0.95972017 |
| 88 | OCT4_18555785_Chip-Seq_ESCs_Mouse | 0.95644905 |
| 89 | RBPJ_21746931_ChIP-Seq_IB4_Human | 0.94685817 |
| 90 | P300_18555785_Chip-Seq_ESCs_Mouse | 0.94559478 |
| 91 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 0.94362037 |
| 92 | PHF8_20622853_ChIP-Seq_HELA_Human | 0.94125096 |
| 93 | CDX2_22108803_ChIP-Seq_LS180_Human | 0.93747164 |
| 94 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.93473314 |
| 95 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 0.93418813 |
| 96 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.92986663 |
| 97 | CIITA_25753668_ChIP-Seq_RAJI_Human | 0.91781343 |
| 98 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.89725368 |
| 99 | CDX2_21074721_ChIP-Seq_CACO-2_Mouse | 0.88408767 |
| 100 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 0.88216389 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0005670_abnormal_white_adipose | 3.74762814 |
| 2 | MP0002102_abnormal_ear_morphology | 3.38403406 |
| 3 | MP0003646_muscle_fatigue | 3.04636115 |
| 4 | MP0006036_abnormal_mitochondrial_physio | 3.00154528 |
| 5 | MP0001835_abnormal_antigen_presentation | 2.73830620 |
| 6 | MP0005645_abnormal_hypothalamus_physiol | 2.68205760 |
| 7 | MP0006292_abnormal_olfactory_placode | 2.43177714 |
| 8 | MP0005075_abnormal_melanosome_morpholog | 2.33841851 |
| 9 | MP0006035_abnormal_mitochondrial_morpho | 2.29653224 |
| 10 | MP0003718_maternal_effect | 2.16652192 |
| 11 | MP0005084_abnormal_gallbladder_morpholo | 2.15689425 |
| 12 | MP0005646_abnormal_pituitary_gland | 2.12093398 |
| 13 | MP0002837_dystrophic_cardiac_calcinosis | 2.07184742 |
| 14 | MP0000372_irregular_coat_pigmentation | 2.06709049 |
| 15 | MP0001986_abnormal_taste_sensitivity | 2.05358584 |
| 16 | MP0008058_abnormal_DNA_repair | 1.99191798 |
| 17 | MP0004147_increased_porphyrin_level | 1.93442438 |
| 18 | MP0000516_abnormal_urinary_system | 1.93316848 |
| 19 | MP0005367_renal/urinary_system_phenotyp | 1.93316848 |
| 20 | MP0004142_abnormal_muscle_tone | 1.87173352 |
| 21 | MP0003786_premature_aging | 1.83340899 |
| 22 | MP0003806_abnormal_nucleotide_metabolis | 1.76847177 |
| 23 | MP0004885_abnormal_endolymph | 1.68547691 |
| 24 | MP0010094_abnormal_chromosome_stability | 1.68119748 |
| 25 | MP0002090_abnormal_vision | 1.60404278 |
| 26 | MP0004134_abnormal_chest_morphology | 1.56069310 |
| 27 | MP0003693_abnormal_embryo_hatching | 1.55036072 |
| 28 | MP0004957_abnormal_blastocyst_morpholog | 1.52656992 |
| 29 | MP0008877_abnormal_DNA_methylation | 1.52188386 |
| 30 | MP0003186_abnormal_redox_activity | 1.47454566 |
| 31 | MP0008872_abnormal_physiological_respon | 1.46262687 |
| 32 | MP0001486_abnormal_startle_reflex | 1.46009059 |
| 33 | MP0003195_calcinosis | 1.45174654 |
| 34 | MP0005551_abnormal_eye_electrophysiolog | 1.44255272 |
| 35 | MP0002751_abnormal_autonomic_nervous | 1.42453762 |
| 36 | MP0005174_abnormal_tail_pigmentation | 1.40907086 |
| 37 | MP0001661_extended_life_span | 1.39893045 |
| 38 | MP0008057_abnormal_DNA_replication | 1.38278715 |
| 39 | MP0003950_abnormal_plasma_membrane | 1.35359892 |
| 40 | MP0001529_abnormal_vocalization | 1.32497294 |
| 41 | MP0001968_abnormal_touch/_nociception | 1.30284105 |
| 42 | MP0002822_catalepsy | 1.29455400 |
| 43 | MP0002163_abnormal_gland_morphology | 1.28631971 |
| 44 | MP0005332_abnormal_amino_acid | 1.28423300 |
| 45 | MP0001800_abnormal_humoral_immune | 1.26838909 |
| 46 | MP0002210_abnormal_sex_determination | 1.23539843 |
| 47 | MP0005408_hypopigmentation | 1.23154168 |
| 48 | MP0002736_abnormal_nociception_after | 1.20367626 |
| 49 | MP0001929_abnormal_gametogenesis | 1.17180670 |
| 50 | MP0006072_abnormal_retinal_apoptosis | 1.16726854 |
| 51 | MP0004215_abnormal_myocardial_fiber | 1.15998436 |
| 52 | MP0002166_altered_tumor_susceptibility | 1.14700880 |
| 53 | MP0005379_endocrine/exocrine_gland_phen | 1.13740449 |
| 54 | MP0002148_abnormal_hypersensitivity_rea | 1.12984730 |
| 55 | MP0002160_abnormal_reproductive_system | 1.12725197 |
| 56 | MP0001293_anophthalmia | 1.12384426 |
| 57 | MP0008875_abnormal_xenobiotic_pharmacok | 1.08299915 |
| 58 | MP0001485_abnormal_pinna_reflex | 1.06991283 |
| 59 | MP0009697_abnormal_copulation | 1.04440118 |
| 60 | MP0003137_abnormal_impulse_conducting | 1.03299530 |
| 61 | MP0005253_abnormal_eye_physiology | 1.02010185 |
| 62 | MP0009745_abnormal_behavioral_response | 1.00852552 |
| 63 | MP0001440_abnormal_grooming_behavior | 1.00630673 |
| 64 | MP0004145_abnormal_muscle_electrophysio | 0.99623752 |
| 65 | MP0000427_abnormal_hair_cycle | 0.99394226 |
| 66 | MP0002272_abnormal_nervous_system | 0.98876761 |
| 67 | MP0001188_hyperpigmentation | 0.98438282 |
| 68 | MP0000653_abnormal_sex_gland | 0.98073152 |
| 69 | MP0004742_abnormal_vestibular_system | 0.97476802 |
| 70 | MP0001145_abnormal_male_reproductive | 0.93321293 |
| 71 | MP0001119_abnormal_female_reproductive | 0.90604537 |
| 72 | MP0005389_reproductive_system_phenotype | 0.90407621 |
| 73 | MP0002938_white_spotting | 0.90370599 |
| 74 | MP0005410_abnormal_fertilization | 0.89845978 |
| 75 | MP0002006_tumorigenesis | 0.88218831 |
| 76 | MP0002396_abnormal_hematopoietic_system | 0.87556665 |
| 77 | MP0005330_cardiomyopathy | 0.85141322 |
| 78 | MP0002452_abnormal_antigen_presenting | 0.83426860 |
| 79 | MP0002723_abnormal_immune_serum | 0.81661007 |
| 80 | MP0000685_abnormal_immune_system | 0.79407579 |
| 81 | MP0005671_abnormal_response_to | 0.76499894 |
| 82 | MP0009785_altered_susceptibility_to | 0.76256438 |
| 83 | MP0008961_abnormal_basal_metabolism | 0.75943919 |
| 84 | MP0002735_abnormal_chemical_nociception | 0.74802898 |
| 85 | MP0001984_abnormal_olfaction | 0.74746451 |
| 86 | MP0004484_altered_response_of | 0.74651656 |
| 87 | MP0009046_muscle_twitch | 0.74094506 |
| 88 | MP0000631_abnormal_neuroendocrine_gland | 0.73315005 |
| 89 | MP0003111_abnormal_nucleus_morphology | 0.72693768 |
| 90 | MP0000569_abnormal_digit_pigmentation | 0.71215720 |
| 91 | MP0004381_abnormal_hair_follicle | 0.70924126 |
| 92 | MP0003077_abnormal_cell_cycle | 0.70679297 |
| 93 | MP0001501_abnormal_sleep_pattern | 0.70100518 |
| 94 | MP0002095_abnormal_skin_pigmentation | 0.68430078 |
| 95 | MP0000647_abnormal_sebaceous_gland | 0.67870404 |
| 96 | MP0003866_abnormal_defecation | 0.66624319 |
| 97 | MP0000371_diluted_coat_color | 0.66441942 |
| 98 | MP0001756_abnormal_urination | 0.65255103 |
| 99 | MP0002876_abnormal_thyroid_physiology | 0.64444222 |
| 100 | MP0001970_abnormal_pain_threshold | 0.64299253 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 5.07273041 |
| 2 | Hepatocellular necrosis (HP:0001404) | 4.63134633 |
| 3 | Mitochondrial inheritance (HP:0001427) | 4.43246596 |
| 4 | Acute encephalopathy (HP:0006846) | 4.42585833 |
| 5 | Hepatic necrosis (HP:0002605) | 4.39074478 |
| 6 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.23556355 |
| 7 | Increased CSF lactate (HP:0002490) | 4.19715821 |
| 8 | Progressive macrocephaly (HP:0004481) | 4.16573148 |
| 9 | Cerebral edema (HP:0002181) | 4.13479599 |
| 10 | 3-Methylglutaconic aciduria (HP:0003535) | 3.63740391 |
| 11 | Cerebral hypomyelination (HP:0006808) | 3.33675575 |
| 12 | Abnormality of midbrain morphology (HP:0002418) | 3.29469502 |
| 13 | Molar tooth sign on MRI (HP:0002419) | 3.29469502 |
| 14 | Increased serum lactate (HP:0002151) | 3.25383431 |
| 15 | Decreased central vision (HP:0007663) | 3.23381389 |
| 16 | Increased hepatocellular lipid droplets (HP:0006565) | 3.15731281 |
| 17 | Congenital, generalized hypertrichosis (HP:0004540) | 2.98970140 |
| 18 | Congenital stationary night blindness (HP:0007642) | 2.91674914 |
| 19 | Respiratory failure (HP:0002878) | 2.85522091 |
| 20 | Lipid accumulation in hepatocytes (HP:0006561) | 2.83135171 |
| 21 | CNS demyelination (HP:0007305) | 2.79030459 |
| 22 | Elevated erythrocyte sedimentation rate (HP:0003565) | 2.77985563 |
| 23 | Leukodystrophy (HP:0002415) | 2.74912599 |
| 24 | Lactic acidosis (HP:0003128) | 2.73790525 |
| 25 | Degeneration of anterior horn cells (HP:0002398) | 2.71978833 |
| 26 | Abnormality of the anterior horn cell (HP:0006802) | 2.71978833 |
| 27 | Hyperglycinuria (HP:0003108) | 2.66085206 |
| 28 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.59978767 |
| 29 | Lethargy (HP:0001254) | 2.58475650 |
| 30 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 2.55687255 |
| 31 | Optic disc pallor (HP:0000543) | 2.55438218 |
| 32 | Renal Fanconi syndrome (HP:0001994) | 2.55387271 |
| 33 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.44149311 |
| 34 | Increased serum pyruvate (HP:0003542) | 2.43822996 |
| 35 | Constricted visual fields (HP:0001133) | 2.43603525 |
| 36 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.40428647 |
| 37 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.40428647 |
| 38 | Duplicated collecting system (HP:0000081) | 2.39116018 |
| 39 | Supernumerary spleens (HP:0009799) | 2.38272225 |
| 40 | Emotional lability (HP:0000712) | 2.36011388 |
| 41 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.33946809 |
| 42 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.31049143 |
| 43 | Abnormality of alanine metabolism (HP:0010916) | 2.31049143 |
| 44 | Hyperalaninemia (HP:0003348) | 2.31049143 |
| 45 | Abnormality of the pons (HP:0007361) | 2.29295150 |
| 46 | Abnormality of the renal cortex (HP:0011035) | 2.26343806 |
| 47 | Renal cortical cysts (HP:0000803) | 2.24690912 |
| 48 | Stomatitis (HP:0010280) | 2.23851557 |
| 49 | Generalized aminoaciduria (HP:0002909) | 2.22601413 |
| 50 | Abnormality of methionine metabolism (HP:0010901) | 2.21781633 |
| 51 | Abnormality of the renal collecting system (HP:0004742) | 2.20946160 |
| 52 | Hypothermia (HP:0002045) | 2.17446440 |
| 53 | Abolished electroretinogram (ERG) (HP:0000550) | 2.15707321 |
| 54 | Postnatal microcephaly (HP:0005484) | 2.13614868 |
| 55 | Spinal muscular atrophy (HP:0007269) | 2.10446094 |
| 56 | Hypoproteinemia (HP:0003075) | 2.10355999 |
| 57 | Exertional dyspnea (HP:0002875) | 2.07000768 |
| 58 | Exercise intolerance (HP:0003546) | 2.06920113 |
| 59 | Azoospermia (HP:0000027) | 2.05916525 |
| 60 | Methylmalonic acidemia (HP:0002912) | 2.04806477 |
| 61 | Chronic sinusitis (HP:0011109) | 2.02416168 |
| 62 | Abnormality of urine glucose concentration (HP:0011016) | 2.01500562 |
| 63 | Glycosuria (HP:0003076) | 2.01500562 |
| 64 | Large for gestational age (HP:0001520) | 2.01099865 |
| 65 | Abnormality of glycolysis (HP:0004366) | 2.00542975 |
| 66 | Tubular atrophy (HP:0000092) | 1.99629571 |
| 67 | Broad-based gait (HP:0002136) | 1.99150477 |
| 68 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 1.98628732 |
| 69 | Cone-rod dystrophy (HP:0000548) | 1.98015807 |
| 70 | Submucous cleft hard palate (HP:0000176) | 1.96917404 |
| 71 | Cleft eyelid (HP:0000625) | 1.96283805 |
| 72 | Clumsiness (HP:0002312) | 1.96235342 |
| 73 | Macular degeneration (HP:0000608) | 1.95416666 |
| 74 | Nephronophthisis (HP:0000090) | 1.95293468 |
| 75 | Abnormal rod and cone electroretinograms (HP:0008323) | 1.94862176 |
| 76 | CNS hypomyelination (HP:0003429) | 1.92595383 |
| 77 | Polydipsia (HP:0001959) | 1.92073086 |
| 78 | Abnormal drinking behavior (HP:0030082) | 1.92073086 |
| 79 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.91931754 |
| 80 | Papilledema (HP:0001085) | 1.90747952 |
| 81 | Pancreatic cysts (HP:0001737) | 1.88965252 |
| 82 | Median cleft lip (HP:0000161) | 1.86719402 |
| 83 | Progressive microcephaly (HP:0000253) | 1.84210583 |
| 84 | Oligodactyly (hands) (HP:0001180) | 1.83373984 |
| 85 | Methylmalonic aciduria (HP:0012120) | 1.81430078 |
| 86 | Muscular hypotonia of the trunk (HP:0008936) | 1.81321568 |
| 87 | Tongue fasciculations (HP:0001308) | 1.80867611 |
| 88 | Ureteral duplication (HP:0000073) | 1.80699721 |
| 89 | Adrenal hypoplasia (HP:0000835) | 1.80213513 |
| 90 | Abnormality of serum amino acid levels (HP:0003112) | 1.78880168 |
| 91 | Short tibia (HP:0005736) | 1.78272337 |
| 92 | Megaloblastic anemia (HP:0001889) | 1.78138848 |
| 93 | Abnormality of glycine metabolism (HP:0010895) | 1.77295333 |
| 94 | Abnormality of serine family amino acid metabolism (HP:0010894) | 1.77295333 |
| 95 | Atonic seizures (HP:0010819) | 1.77083519 |
| 96 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 1.75606004 |
| 97 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 1.75606004 |
| 98 | Volvulus (HP:0002580) | 1.75277808 |
| 99 | Abnormality of the renal medulla (HP:0100957) | 1.74897277 |
| 100 | Delusions (HP:0000746) | 1.74651249 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EIF2AK1 | 5.37610479 |
| 2 | MST4 | 4.98332720 |
| 3 | EIF2AK3 | 4.03791472 |
| 4 | BMPR2 | 3.35904937 |
| 5 | STK39 | 3.29261784 |
| 6 | OXSR1 | 2.91673507 |
| 7 | TSSK6 | 2.56179893 |
| 8 | PLK4 | 2.53017073 |
| 9 | VRK2 | 2.30153784 |
| 10 | NUAK1 | 1.97138856 |
| 11 | MAP3K12 | 1.91282917 |
| 12 | CCNB1 | 1.85119609 |
| 13 | BUB1 | 1.82479023 |
| 14 | WNK4 | 1.81521995 |
| 15 | MKNK2 | 1.72626048 |
| 16 | TRIM28 | 1.70554504 |
| 17 | NEK1 | 1.68275211 |
| 18 | CDK19 | 1.67176240 |
| 19 | STK38L | 1.57543844 |
| 20 | VRK1 | 1.52042655 |
| 21 | EIF2AK2 | 1.42535279 |
| 22 | PLK3 | 1.41939331 |
| 23 | PLK2 | 1.41880255 |
| 24 | ERBB3 | 1.39402604 |
| 25 | SRPK1 | 1.35676474 |
| 26 | TLK1 | 1.30322409 |
| 27 | TEC | 1.29925184 |
| 28 | CDC7 | 1.23471730 |
| 29 | ACVR1B | 1.17697220 |
| 30 | WNK3 | 1.17559945 |
| 31 | FRK | 1.17033913 |
| 32 | GRK1 | 1.14489778 |
| 33 | WEE1 | 1.13861354 |
| 34 | CSNK1A1L | 1.10428058 |
| 35 | BMPR1B | 1.08007217 |
| 36 | PDK2 | 1.00255121 |
| 37 | MYLK | 0.97746317 |
| 38 | MKNK1 | 0.93814079 |
| 39 | ADRBK2 | 0.93492251 |
| 40 | PLK1 | 0.88048665 |
| 41 | MAP2K6 | 0.87629576 |
| 42 | PHKG2 | 0.86017429 |
| 43 | PHKG1 | 0.86017429 |
| 44 | IKBKB | 0.85201158 |
| 45 | TNIK | 0.82465228 |
| 46 | CSNK1G3 | 0.82076175 |
| 47 | STK16 | 0.81681016 |
| 48 | TXK | 0.79154399 |
| 49 | NME2 | 0.76541498 |
| 50 | BRD4 | 0.75584891 |
| 51 | TYK2 | 0.74034051 |
| 52 | MAP4K2 | 0.73395364 |
| 53 | CSNK1G1 | 0.72767915 |
| 54 | ZAK | 0.70992556 |
| 55 | BCR | 0.70656938 |
| 56 | RPS6KA4 | 0.69618710 |
| 57 | STK3 | 0.68548415 |
| 58 | KIT | 0.68537147 |
| 59 | ILK | 0.67348461 |
| 60 | MAP3K4 | 0.66986610 |
| 61 | NME1 | 0.66450377 |
| 62 | PIK3CG | 0.65947891 |
| 63 | INSRR | 0.62158249 |
| 64 | ITK | 0.61128242 |
| 65 | AURKB | 0.56340582 |
| 66 | CSNK1G2 | 0.56308573 |
| 67 | PRKCE | 0.56215173 |
| 68 | CSF1R | 0.56019353 |
| 69 | GRK5 | 0.55178182 |
| 70 | ATR | 0.54958842 |
| 71 | STK4 | 0.49757669 |
| 72 | ABL2 | 0.47076950 |
| 73 | BCKDK | 0.45286266 |
| 74 | CSNK2A1 | 0.44676461 |
| 75 | CSNK2A2 | 0.42868143 |
| 76 | RIPK4 | 0.42570847 |
| 77 | DYRK3 | 0.42266954 |
| 78 | TRPM7 | 0.41797605 |
| 79 | PASK | 0.40164309 |
| 80 | EPHA4 | 0.39153315 |
| 81 | ERBB4 | 0.37827272 |
| 82 | PRKG1 | 0.37810473 |
| 83 | CHEK1 | 0.37316496 |
| 84 | SYK | 0.37247801 |
| 85 | PRKCG | 0.36153512 |
| 86 | ADRBK1 | 0.35448853 |
| 87 | CSNK1E | 0.34293446 |
| 88 | AKT2 | 0.34289284 |
| 89 | MAPKAPK5 | 0.33261733 |
| 90 | IGF1R | 0.32940729 |
| 91 | DAPK1 | 0.31793658 |
| 92 | MINK1 | 0.31502023 |
| 93 | CHUK | 0.31342092 |
| 94 | RPS6KA5 | 0.30484644 |
| 95 | FGFR1 | 0.30371118 |
| 96 | AKT3 | 0.29705709 |
| 97 | TAF1 | 0.29626444 |
| 98 | OBSCN | 0.28212426 |
| 99 | MAP2K7 | 0.27952121 |
| 100 | ATM | 0.25521884 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 5.08973214 |
| 2 | Asthma_Homo sapiens_hsa05310 | 3.59628579 |
| 3 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.32710010 |
| 4 | Parkinsons disease_Homo sapiens_hsa05012 | 2.83200892 |
| 5 | Graft-versus-host disease_Homo sapiens_hsa05332 | 2.57257402 |
| 6 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 2.49557376 |
| 7 | Allograft rejection_Homo sapiens_hsa05330 | 2.48475648 |
| 8 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.47646680 |
| 9 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 2.38151809 |
| 10 | Sulfur metabolism_Homo sapiens_hsa00920 | 2.30308411 |
| 11 | Protein export_Homo sapiens_hsa03060 | 2.30302444 |
| 12 | RNA polymerase_Homo sapiens_hsa03020 | 2.19901939 |
| 13 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 2.14577702 |
| 14 | Huntingtons disease_Homo sapiens_hsa05016 | 2.03424559 |
| 15 | RNA degradation_Homo sapiens_hsa03018 | 1.95529650 |
| 16 | Spliceosome_Homo sapiens_hsa03040 | 1.81975143 |
| 17 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.78928049 |
| 18 | Basal transcription factors_Homo sapiens_hsa03022 | 1.70345804 |
| 19 | Alzheimers disease_Homo sapiens_hsa05010 | 1.70247527 |
| 20 | Homologous recombination_Homo sapiens_hsa03440 | 1.69016380 |
| 21 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.65683139 |
| 22 | Mismatch repair_Homo sapiens_hsa03430 | 1.63686418 |
| 23 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.62865264 |
| 24 | RNA transport_Homo sapiens_hsa03013 | 1.62851367 |
| 25 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.60791668 |
| 26 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.45598527 |
| 27 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.44982409 |
| 28 | Ribosome_Homo sapiens_hsa03010 | 1.42788786 |
| 29 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 1.42648981 |
| 30 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.38195034 |
| 31 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.35387958 |
| 32 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.34909180 |
| 33 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.30810857 |
| 34 | Viral myocarditis_Homo sapiens_hsa05416 | 1.24574090 |
| 35 | DNA replication_Homo sapiens_hsa03030 | 1.24423769 |
| 36 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.19764876 |
| 37 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.16012349 |
| 38 | Purine metabolism_Homo sapiens_hsa00230 | 1.14477912 |
| 39 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.13633424 |
| 40 | Phototransduction_Homo sapiens_hsa04744 | 1.11733743 |
| 41 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.05355570 |
| 42 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.03711733 |
| 43 | Regulation of autophagy_Homo sapiens_hsa04140 | 1.01339765 |
| 44 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.00169982 |
| 45 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.99854630 |
| 46 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.94833005 |
| 47 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.92117913 |
| 48 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.86415416 |
| 49 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.84157022 |
| 50 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.79886707 |
| 51 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.77793767 |
| 52 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.75661654 |
| 53 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.72614891 |
| 54 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.72194280 |
| 55 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.71916346 |
| 56 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.65157555 |
| 57 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.61082700 |
| 58 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.60736294 |
| 59 | Olfactory transduction_Homo sapiens_hsa04740 | 0.59912002 |
| 60 | Leishmaniasis_Homo sapiens_hsa05140 | 0.58990597 |
| 61 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.57916931 |
| 62 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.57829795 |
| 63 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.56277665 |
| 64 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.54438586 |
| 65 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.54344019 |
| 66 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.51469254 |
| 67 | Legionellosis_Homo sapiens_hsa05134 | 0.50715969 |
| 68 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.49826738 |
| 69 | Peroxisome_Homo sapiens_hsa04146 | 0.49318149 |
| 70 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.48253316 |
| 71 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.47091767 |
| 72 | Metabolic pathways_Homo sapiens_hsa01100 | 0.46548637 |
| 73 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.42417595 |
| 74 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.40215772 |
| 75 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.38721405 |
| 76 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.38052855 |
| 77 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.37203110 |
| 78 | Tuberculosis_Homo sapiens_hsa05152 | 0.37150911 |
| 79 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.36125013 |
| 80 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.35198910 |
| 81 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.35020603 |
| 82 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.34418400 |
| 83 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.34027548 |
| 84 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.33901761 |
| 85 | Taste transduction_Homo sapiens_hsa04742 | 0.33392688 |
| 86 | Cell cycle_Homo sapiens_hsa04110 | 0.33139680 |
| 87 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.28714022 |
| 88 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.25341601 |
| 89 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.24494892 |
| 90 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.23219505 |
| 91 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.22594307 |
| 92 | Shigellosis_Homo sapiens_hsa05131 | 0.21894740 |
| 93 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.21676000 |
| 94 | Influenza A_Homo sapiens_hsa05164 | 0.21284157 |
| 95 | Phagosome_Homo sapiens_hsa04145 | 0.21117489 |
| 96 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.20964450 |
| 97 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.19104593 |
| 98 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.18424721 |
| 99 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.17968504 |
| 100 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.17742689 |

