CYFIP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.60499050
2positive regulation by organism of defense response of other organism involved in symbiotic interact6.60499050
3modulation by symbiont of host immune response (GO:0052553)6.60499050
4positive regulation by symbiont of host defense response (GO:0052509)6.60499050
5modulation by symbiont of host defense response (GO:0052031)6.60499050
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.60499050
7microglial cell activation (GO:0001774)6.33327271
8macrophage activation involved in immune response (GO:0002281)5.78620572
9regulation of interferon-beta biosynthetic process (GO:0045357)5.46565607
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.88240087
11positive regulation of interferon-alpha production (GO:0032727)4.76255302
12barbed-end actin filament capping (GO:0051016)4.69995419
13protein localization to endosome (GO:0036010)4.57488687
14regulation of interferon-alpha production (GO:0032647)4.56635597
15macrophage activation (GO:0042116)4.34806173
16Golgi transport vesicle coating (GO:0048200)4.21974152
17COPI coating of Golgi vesicle (GO:0048205)4.21974152
18response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.20415300
19response to host (GO:0075136)4.20415300
20response to host defenses (GO:0052200)4.20415300
21response to host immune response (GO:0052572)4.17981556
22response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.17981556
23response to peptidoglycan (GO:0032494)4.12686033
24dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.94960021
25G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.91031591
26glycolipid catabolic process (GO:0019377)3.90249461
27neutrophil activation involved in immune response (GO:0002283)3.88301813
28hemidesmosome assembly (GO:0031581)3.85651007
29I-kappaB phosphorylation (GO:0007252)3.81917770
30epithelial cell-cell adhesion (GO:0090136)3.79702668
31positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.66314784
32epithelial cell differentiation involved in prostate gland development (GO:0060742)3.58136408
33response to muramyl dipeptide (GO:0032495)3.57431365
34skin morphogenesis (GO:0043589)3.55272132
35positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.55112755
36oligosaccharide catabolic process (GO:0009313)3.51376121
37positive regulation of antigen processing and presentation (GO:0002579)3.48955551
38cell adhesion mediated by integrin (GO:0033627)3.47896147
39cytoskeletal anchoring at plasma membrane (GO:0007016)3.47894206
40positive regulation of chemokine secretion (GO:0090197)3.46787328
41positive regulation of cellular amide metabolic process (GO:0034250)3.40130599
42regulation of early endosome to late endosome transport (GO:2000641)3.39319611
43myeloid cell activation involved in immune response (GO:0002275)3.37219988
44ceramide catabolic process (GO:0046514)3.32121214
45apoptotic cell clearance (GO:0043277)3.31103017
46positive regulation of interferon-beta production (GO:0032728)3.30216331
47stress fiber assembly (GO:0043149)3.29754759
48lipopolysaccharide-mediated signaling pathway (GO:0031663)3.20534195
49cell-substrate junction assembly (GO:0007044)3.15824445
50retina vasculature morphogenesis in camera-type eye (GO:0061299)3.14524655
51protein retention in ER lumen (GO:0006621)3.13620866
52adhesion of symbiont to host (GO:0044406)3.12748186
53hyaluronan catabolic process (GO:0030214)3.10597942
54regulation of dendritic cell antigen processing and presentation (GO:0002604)3.09839690
55regulation of B cell receptor signaling pathway (GO:0050855)3.08908197
56immunoglobulin mediated immune response (GO:0016064)3.08686804
57maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.07611328
58regulation of mononuclear cell migration (GO:0071675)3.06237368
59pinocytosis (GO:0006907)3.05980664
60semaphorin-plexin signaling pathway (GO:0071526)3.05654616
61positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.03063310
62adhesion of symbiont to host cell (GO:0044650)3.02806860
63virion attachment to host cell (GO:0019062)3.02806860
64endodermal cell differentiation (GO:0035987)3.01978855
65regulation of chemokine secretion (GO:0090196)3.00346390
66basement membrane organization (GO:0071711)2.99918844
67wound healing, spreading of epidermal cells (GO:0035313)2.99384438
68desmosome organization (GO:0002934)2.98733887
69negative regulation of granulocyte differentiation (GO:0030853)2.98551952
70detection of molecule of bacterial origin (GO:0032490)2.98139160
71regulation of antigen processing and presentation (GO:0002577)2.95686649
72respiratory burst (GO:0045730)2.94668223
73positive regulation of receptor recycling (GO:0001921)2.92418085
74amino sugar catabolic process (GO:0046348)2.91414779
75production of molecular mediator involved in inflammatory response (GO:0002532)2.91037858
76phagocytosis, engulfment (GO:0006911)2.90322446
77positive regulation of macrophage cytokine production (GO:0060907)2.86627220
78adherens junction assembly (GO:0034333)2.86515487
79granulocyte activation (GO:0036230)2.83669443
80planar cell polarity pathway involved in neural tube closure (GO:0090179)2.83462906
81regulation of membrane protein ectodomain proteolysis (GO:0051043)2.83053929
82glial cell migration (GO:0008347)2.82388315
83cellular extravasation (GO:0045123)2.79618924
84cortical actin cytoskeleton organization (GO:0030866)2.78625716
85regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.77766345
86membrane lipid catabolic process (GO:0046466)2.76961722
87regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.76664439
88positive regulation of chemokine production (GO:0032722)2.76648998
89positive regulation of chemokine biosynthetic process (GO:0045080)2.75999775
90regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.75872391
91positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.75494729
92retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.73777303
93mannose metabolic process (GO:0006013)2.73037361
94neutrophil activation (GO:0042119)2.73001784
95response to thyroid hormone (GO:0097066)2.72422082
96response to laminar fluid shear stress (GO:0034616)2.71511724
97positive regulation of monocyte chemotaxis (GO:0090026)2.70379356
98osteoclast differentiation (GO:0030316)2.70163045
99positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.69435745
100sphingolipid catabolic process (GO:0030149)2.69251438
101regulation of monocyte chemotaxis (GO:0090025)2.69101769
102membrane protein ectodomain proteolysis (GO:0006509)2.69069743
103keratan sulfate catabolic process (GO:0042340)2.68706055
104regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.68099010
105regulation of macrophage chemotaxis (GO:0010758)2.67151478
106G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.66854813
107endothelial cell chemotaxis (GO:0035767)2.65130735
108regulation of interleukin-8 biosynthetic process (GO:0045414)2.64689516
109regulation of chemokine-mediated signaling pathway (GO:0070099)2.64589169
110cytokine secretion (GO:0050663)2.63954460
111regulation of integrin activation (GO:0033623)2.63606112
112positive regulation of leukocyte degranulation (GO:0043302)2.62897948
113low-density lipoprotein particle clearance (GO:0034383)2.62717062
114peptide catabolic process (GO:0043171)2.61719228
115surfactant homeostasis (GO:0043129)2.61717645
116decidualization (GO:0046697)2.61425877
117purinergic nucleotide receptor signaling pathway (GO:0035590)2.60698466
118substrate-dependent cell migration (GO:0006929)2.60067614
119positive regulation of Cdc42 GTPase activity (GO:0043089)2.59748607
120glycosphingolipid catabolic process (GO:0046479)2.57119102
121collagen metabolic process (GO:0032963)2.56998902
122chondroitin sulfate catabolic process (GO:0030207)2.56311121
123germinal center formation (GO:0002467)2.56143688
124positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.54996123
125cell-cell junction maintenance (GO:0045217)2.54944090
126myeloid leukocyte activation (GO:0002274)2.54903448
127negative regulation of interleukin-17 production (GO:0032700)2.54832397
128cortical cytoskeleton organization (GO:0030865)2.54335962
129vascular endothelial growth factor signaling pathway (GO:0038084)2.52988125
130macrophage chemotaxis (GO:0048246)2.52480588
131focal adhesion assembly (GO:0048041)2.51201535
132cell-substrate adherens junction assembly (GO:0007045)2.51201535
133pentose-phosphate shunt (GO:0006098)2.50998355
134positive regulation of endothelial cell apoptotic process (GO:2000353)2.50240803
135cellular response to thyroid hormone stimulus (GO:0097067)2.49629040
136collagen catabolic process (GO:0030574)2.49204829
137branching involved in mammary gland duct morphogenesis (GO:0060444)2.49159579
138regulation of macrophage cytokine production (GO:0010935)2.48760720
139regulation of mast cell activation involved in immune response (GO:0033006)2.48372159
140regulation of mast cell degranulation (GO:0043304)2.48280260
141negative regulation of protein localization to plasma membrane (GO:1903077)2.47167439
142wound healing, spreading of cells (GO:0044319)2.46260314
143embryo implantation (GO:0007566)2.46047458
144extracellular matrix disassembly (GO:0022617)2.46017522
145multicellular organismal macromolecule metabolic process (GO:0044259)2.45558550
146regulation of cholesterol storage (GO:0010885)2.45202728
147positive regulation of interleukin-1 beta secretion (GO:0050718)2.45057389
148positive regulation of extracellular matrix organization (GO:1903055)2.44623047
149positive regulation of interleukin-6 production (GO:0032755)2.43998246
150hypotonic response (GO:0006971)2.43841842
151positive regulation of interleukin-12 production (GO:0032735)2.42814253
152natural killer cell mediated cytotoxicity (GO:0042267)2.42792964
153natural killer cell mediated immunity (GO:0002228)2.42792964
154monocyte chemotaxis (GO:0002548)2.42514613
155regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.42039819
156regulation of apoptotic cell clearance (GO:2000425)2.41453015
157cellular copper ion homeostasis (GO:0006878)2.41362376
158regulation of podosome assembly (GO:0071801)2.40838806
159positive regulation of toll-like receptor signaling pathway (GO:0034123)2.40740144
160positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.40666210
161neutrophil mediated immunity (GO:0002446)2.40127176
162cellular response to interferon-alpha (GO:0035457)2.38931027
163regulation of interferon-beta production (GO:0032648)2.38334059
164positive regulation of NF-kappaB import into nucleus (GO:0042346)2.38130199
165negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.36465267
166NADPH regeneration (GO:0006740)2.35709834
167negative regulation of interleukin-12 production (GO:0032695)2.35598785
168NIK/NF-kappaB signaling (GO:0038061)2.35439088
169positive regulation of p38MAPK cascade (GO:1900745)2.35354460
170iron ion import (GO:0097286)2.34654232
171positive regulation of phagocytosis (GO:0050766)2.34314711
172response to interferon-alpha (GO:0035455)2.34158808
173adenosine receptor signaling pathway (GO:0001973)2.33906615
174negative regulation of systemic arterial blood pressure (GO:0003085)2.33710053
175chondrocyte proliferation (GO:0035988)2.33647175
176vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.33080420
177amyloid precursor protein catabolic process (GO:0042987)2.32034162
178multicellular organismal catabolic process (GO:0044243)2.31985726
179multicellular organismal metabolic process (GO:0044236)2.30683990
180vesicle coating (GO:0006901)2.28709290
181gap junction assembly (GO:0016264)2.27995440
182actin filament bundle organization (GO:0061572)2.24575452

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse5.59509700
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.67246798
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.42280008
4TP63_17297297_ChIP-ChIP_HaCaT_Human4.40154249
5IRF8_22096565_ChIP-ChIP_GC-B_Human4.25913868
6* IRF8_27001747_Chip-Seq_BMDM_Mouse3.96393720
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.76707915
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.69586969
9Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.36373771
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.32858510
11NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.12230127
12TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.61057038
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.56473060
14* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.38163395
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.37748698
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.32815009
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.30865998
18TRIM28_21343339_ChIP-Seq_HEK293_Human2.28213056
19NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.25895907
20MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.24317998
21ZNF263_19887448_ChIP-Seq_K562_Human2.20732427
22IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.97844843
23RACK7_27058665_Chip-Seq_MCF-7_Human1.96175573
24PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.95274659
25PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.94994046
26SMAD_19615063_ChIP-ChIP_OVARY_Human1.93904058
27LXR_22292898_ChIP-Seq_THP-1_Human1.90475805
28BRD4_27068464_Chip-Seq_AML-cells_Mouse1.87296494
29VDR_24787735_ChIP-Seq_THP-1_Human1.85658800
30SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.84442163
31TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.79162260
32WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.73865160
33GATA2_21666600_ChIP-Seq_HMVEC_Human1.71129131
34SPI1_23127762_ChIP-Seq_K562_Human1.67549669
35P300_27058665_Chip-Seq_ZR-75-30cells_Human1.67289931
36SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.66427013
37SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.66427013
38STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.66378568
39ESR1_21235772_ChIP-Seq_MCF-7_Human1.66231437
40RARG_19884340_ChIP-ChIP_MEFs_Mouse1.65636008
41TP53_16413492_ChIP-PET_HCT116_Human1.65253799
42VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.62157736
43STAT6_21828071_ChIP-Seq_BEAS2B_Human1.61871605
44SCL_19346495_ChIP-Seq_HPC-7_Human1.59651819
45CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.57660742
46TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.57622464
47CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.57028279
48PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.56761693
49ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.56567523
50PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.55176663
51PU_27001747_Chip-Seq_BMDM_Mouse1.52122746
52KDM2B_26808549_Chip-Seq_K562_Human1.51280397
53ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.50728388
54VDR_21846776_ChIP-Seq_THP-1_Human1.49594947
55TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.48954941
56CLOCK_20551151_ChIP-Seq_293T_Human1.48738877
57AR_21909140_ChIP-Seq_LNCAP_Human1.46558380
58FOXM1_23109430_ChIP-Seq_U2OS_Human1.43787885
59NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.42675555
60POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.42055458
61KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.42027396
62SALL4_18804426_ChIP-ChIP_XEN_Mouse1.41690336
63CJUN_26792858_Chip-Seq_BT549_Human1.41343976
64SPI1_23547873_ChIP-Seq_NB4_Human1.41013990
65UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.40796312
66STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.38208469
67* ATF3_27146783_Chip-Seq_COLON_Human1.36296268
68RUNX_20019798_ChIP-Seq_JUKART_Human1.36254568
69KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.35404007
70SOX2_27498859_Chip-Seq_STOMACH_Mouse1.35273201
71SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.34174401
72BRD4_25478319_ChIP-Seq_HGPS_Human1.33936890
73ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.33502613
74WT1_19549856_ChIP-ChIP_CCG9911_Human1.30471058
75RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.30108791
76NRF2_20460467_ChIP-Seq_MEFs_Mouse1.28501993
77NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.28501993
78VDR_24763502_ChIP-Seq_THP-1_Human1.28117532
79TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.26964467
80TBX20_22328084_ChIP-Seq_HEART_Mouse1.25893211
81TBX20_22080862_ChIP-Seq_HEART_Mouse1.25893211
82SOX2_20726797_ChIP-Seq_SW620_Human1.25560527
83NFIB_24661679_ChIP-Seq_LUNG_Mouse1.25353631
84TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23329624
85ESR2_21235772_ChIP-Seq_MCF-7_Human1.22873145
86NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.21368916
87FOXO3_23340844_ChIP-Seq_DLD1_Human1.21219977
88TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.19625330
89SOX9_24532713_ChIP-Seq_HFSC_Mouse1.19068726
90ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.18880890
91TP53_22127205_ChIP-Seq_IMR90_Human1.18504021
92ZNF217_24962896_ChIP-Seq_MCF-7_Human1.18407492
93RUNX1_22412390_ChIP-Seq_EML_Mouse1.17168423
94RXR_22158963_ChIP-Seq_LIVER_Mouse1.16380773
95RUNX1_27514584_Chip-Seq_MCF-7_Human1.15525670
96DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.14913879
97* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.13115179
98* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.12211869
99NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.11197397
100JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10671050
101HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.08555879
102FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07496859
103* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.07450316
104SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.06882184
105GATA1_22025678_ChIP-Seq_K562_Human1.05861485
106STAT4_19710469_ChIP-ChIP_TH1__Mouse1.05817569
107ZFP281_18757296_ChIP-ChIP_E14_Mouse1.05260944
108JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04746490
109KDM2B_26808549_Chip-Seq_DND41_Human1.04541374
110TP53_18474530_ChIP-ChIP_U2OS_Human1.03824696
111NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.02048409
112HIF1A_21447827_ChIP-Seq_MCF-7_Human1.01882020
113SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01496925
114ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.01173521
115PPARA_22158963_ChIP-Seq_LIVER_Mouse1.01092629
116CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01018576
117CDX2_20551321_ChIP-Seq_CACO-2_Human1.00823157
118SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.00585738
119ELK3_25401928_ChIP-Seq_HUVEC_Human1.00177617
120KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.99278486
121KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.99278486
122KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.99278486
123TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.98088538
124TCF7_22412390_ChIP-Seq_EML_Mouse0.97459819
125EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.95118753
126FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.95049368
127ERG_21242973_ChIP-ChIP_JURKAT_Human0.94927446
128KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.94845043
129THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.94412843
130LXR_22158963_ChIP-Seq_LIVER_Mouse0.94240668
131SMC1_22415368_ChIP-Seq_MEFs_Mouse0.93704002
132CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92771898
133FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.92724795
134CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.92406258
135SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.91967808
136FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.91511410
137E2F7_22180533_ChIP-Seq_HELA_Human0.91425171
138CDX2_19796622_ChIP-Seq_MESCs_Mouse0.90761085
139TFEB_21752829_ChIP-Seq_HELA_Human0.90690508
140RXR_22108803_ChIP-Seq_LS180_Human0.90607990
141DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.89958791
142EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.89703492
143MYB_26560356_Chip-Seq_TH2_Human0.89261386
144STAT3_1855785_ChIP-Seq_MESCs_Mouse0.89098105
145MAF_26560356_Chip-Seq_TH1_Human0.89085091
146P63_26484246_Chip-Seq_KERATINOCYTES_Human0.88646526
147* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.88290424
148KDM2B_26808549_Chip-Seq_SUP-B15_Human0.87240037
149BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.85904053
150TCF4_18268006_ChIP-ChIP_LS174T_Human0.83823234
151ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.82867676
152KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.81833127
153UBF1/2_26484160_Chip-Seq_HMECs_Human0.80253097

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology3.65841546
2MP0001835_abnormal_antigen_presentation3.18731842
3MP0010234_abnormal_vibrissa_follicle3.06200734
4MP0006082_CNS_inflammation3.06043108
5MP0003303_peritoneal_inflammation3.00181643
6MP0008438_abnormal_cutaneous_collagen2.93631495
7MP0002877_abnormal_melanocyte_morpholog2.70610063
8MP0003172_abnormal_lysosome_physiology2.69559520
9MP0003436_decreased_susceptibility_to2.67769104
10MP0002419_abnormal_innate_immunity2.54479341
11MP0002254_reproductive_system_inflammat2.34841857
12MP0003566_abnormal_cell_adhesion2.26879560
13MP0003191_abnormal_cellular_cholesterol2.18946874
14MP0002148_abnormal_hypersensitivity_rea2.17507699
15MP0000569_abnormal_digit_pigmentation2.15803782
16MP0003705_abnormal_hypodermis_morpholog2.14729723
17MP0003690_abnormal_glial_cell2.12910571
18MP0005464_abnormal_platelet_physiology2.05216025
19MP0003075_altered_response_to2.04005066
20MP0003300_gastrointestinal_ulcer1.94245741
21MP0001533_abnormal_skeleton_physiology1.91838749
22MP0005000_abnormal_immune_tolerance1.86277258
23MP0002452_abnormal_antigen_presenting1.85337332
24MP0005451_abnormal_body_composition1.80435739
25MP0010307_abnormal_tumor_latency1.77343069
26MP0009785_altered_susceptibility_to1.76657171
27MP0003724_increased_susceptibility_to1.73681070
28MP0005257_abnormal_intraocular_pressure1.68895792
29MP0002796_impaired_skin_barrier1.67142297
30MP0002896_abnormal_bone_mineralization1.66608989
31MP0001958_emphysema1.66429001
32MP0000343_altered_response_to1.64366946
33MP0005409_darkened_coat_color1.64136121
34MP0005025_abnormal_response_to1.61984085
35MP0003279_aneurysm1.60325730
36MP0005023_abnormal_wound_healing1.59744902
37MP0003448_altered_tumor_morphology1.59672926
38MP0002998_abnormal_bone_remodeling1.59427190
39MP0003045_fibrosis1.58842212
40MP0005167_abnormal_blood-brain_barrier1.57904623
41MP0004510_myositis1.56195779
42MP0009278_abnormal_bone_marrow1.54905457
43MP0005076_abnormal_cell_differentiation1.54540380
44MP0003329_amyloid_beta_deposits1.53883527
45MP0004947_skin_inflammation1.52819449
46MP0009384_cardiac_valve_regurgitation1.52480581
47MP0003091_abnormal_cell_migration1.52187822
48MP0005275_abnormal_skin_tensile1.50693967
49MP0005387_immune_system_phenotype1.48914199
50MP0001790_abnormal_immune_system1.48914199
51MP0000767_abnormal_smooth_muscle1.48778848
52MP0002723_abnormal_immune_serum1.44939562
53MP0010352_gastrointestinal_tract_polyps1.41526624
54MP0001915_intracranial_hemorrhage1.40151669
55MP0004185_abnormal_adipocyte_glucose1.39771932
56MP0003828_pulmonary_edema1.38766769
57MP0001819_abnormal_immune_cell1.38215909
58MP0004883_abnormal_blood_vessel1.38013727
59MP0001800_abnormal_humoral_immune1.37362893
60MP0004272_abnormal_basement_membrane1.35842619
61MP0000685_abnormal_immune_system1.35721033
62MP0005671_abnormal_response_to1.34890062
63MP0003453_abnormal_keratinocyte_physiol1.34793781
64MP0004233_abnormal_muscle_weight1.34546040
65MP0002420_abnormal_adaptive_immunity1.33307885
66MP0005164_abnormal_response_to1.31957572
67MP0005166_decreased_susceptibility_to1.31017923
68MP0008260_abnormal_autophagy1.29964572
69MP0000537_abnormal_urethra_morphology1.28449810
70MP0000858_altered_metastatic_potential1.25758857
71MP0003941_abnormal_skin_development1.24397077
72MP0005390_skeleton_phenotype1.21538178
73MP0002006_tumorigenesis1.19803771
74MP0009840_abnormal_foam_cell1.18207245
75MP0001216_abnormal_epidermal_layer1.14359795
76MP0010030_abnormal_orbit_morphology1.14311739
77MP0009053_abnormal_anal_canal1.14285331
78MP0003183_abnormal_peptide_metabolism1.12229625
79MP0005171_absent_coat_pigmentation1.11800318
80MP0005501_abnormal_skin_physiology1.11079165
81MP0002166_altered_tumor_susceptibility1.10831841
82MP0001853_heart_inflammation1.10522142
83MP0001845_abnormal_inflammatory_respons1.09852383
84MP0000249_abnormal_blood_vessel1.08281480
85MP0001851_eye_inflammation1.07654332
86MP0002139_abnormal_hepatobiliary_system1.07320931
87MP0006054_spinal_hemorrhage1.06537580
88MP0000604_amyloidosis1.06350352
89MP0000733_abnormal_muscle_development1.05763450
90MP0005248_abnormal_Harderian_gland1.04338538
91MP0004858_abnormal_nervous_system1.04193543
92MP0004264_abnormal_extraembryonic_tissu1.03020878
93MP0008469_abnormal_protein_level1.02331518
94MP0002405_respiratory_system_inflammati1.01837911
95MP0001542_abnormal_bone_strength1.01563655
96MP0005595_abnormal_vascular_smooth1.00760816
97MP0005508_abnormal_skeleton_morphology0.98455635
98MP0003634_abnormal_glial_cell0.96616136
99MP0002933_joint_inflammation0.96110787
100MP0000579_abnormal_nail_morphology0.95940424
101MP0002098_abnormal_vibrissa_morphology0.95322844
102MP0003950_abnormal_plasma_membrane0.94221913
103MP0010155_abnormal_intestine_physiology0.93001385
104MP0005397_hematopoietic_system_phenotyp0.92940747
105MP0001545_abnormal_hematopoietic_system0.92940747
106MP0008007_abnormal_cellular_replicative0.92345269
107MP0008004_abnormal_stomach_pH0.92290595
108MP0000371_diluted_coat_color0.89907709
109MP0010368_abnormal_lymphatic_system0.88498332
110MP0002168_other_aberrant_phenotype0.88244291
111MP0003795_abnormal_bone_structure0.87898610
112MP0005623_abnormal_meninges_morphology0.87848522
113MP0005197_abnormal_uvea_morphology0.87754749
114MP0001879_abnormal_lymphatic_vessel0.87642992
115MP0002060_abnormal_skin_morphology0.86199942
116MP0010678_abnormal_skin_adnexa0.86082632
117MP0009764_decreased_sensitivity_to0.85580718
118MP0004808_abnormal_hematopoietic_stem0.85001262
119MP0005666_abnormal_adipose_tissue0.84891603
120MP0000383_abnormal_hair_follicle0.84803407
121MP0001243_abnormal_dermal_layer0.84467297
122MP0000716_abnormal_immune_system0.82147269
123MP0004782_abnormal_surfactant_physiolog0.81457293
124MP0002277_abnormal_respiratory_mucosa0.81248495
125MP0001849_ear_inflammation0.79593706
126MP0005165_increased_susceptibility_to0.78549561
127MP0000377_abnormal_hair_follicle0.76263557
128MP0000920_abnormal_myelination0.75550023
129MP0005310_abnormal_salivary_gland0.75069494
130MP0005621_abnormal_cell_physiology0.74628643
131MP0000627_abnormal_mammary_gland0.74498252
132MP0009333_abnormal_splenocyte_physiolog0.74445118
133MP0000762_abnormal_tongue_morphology0.73100896
134MP0000467_abnormal_esophagus_morphology0.70665358
135MP0001614_abnormal_blood_vessel0.70260843
136MP0005193_abnormal_anterior_eye0.69808838
137MP0002089_abnormal_postnatal_growth/wei0.68396575
138MP0000747_muscle_weakness0.67345408
139MP0005375_adipose_tissue_phenotype0.67166372
140MP0002092_abnormal_eye_morphology0.67144867

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)5.11589065
2Recurrent abscess formation (HP:0002722)4.74261750
3Eczematoid dermatitis (HP:0000976)4.41994743
4Recurrent bacterial skin infections (HP:0005406)4.23209860
5Increased cerebral lipofuscin (HP:0011813)4.13186327
6Abnormality of liposaccharide metabolism (HP:0010968)3.94617906
7Abnormality of glycosphingolipid metabolism (HP:0004343)3.94617906
8Abnormality of glycolipid metabolism (HP:0010969)3.94617906
9Increased neuronal autofluorescent lipopigment (HP:0002074)3.77111875
10Dysostosis multiplex (HP:0000943)3.59350505
11Glomerulonephritis (HP:0000099)3.50073857
12Arterial tortuosity (HP:0005116)3.44149653
13Vacuolated lymphocytes (HP:0001922)3.44113455
14Recurrent gram-negative bacterial infections (HP:0005420)3.39416555
15Cervical subluxation (HP:0003308)3.31969577
16Hematochezia (HP:0002573)3.24546702
17Cerebral aneurysm (HP:0004944)3.21820435
18Vascular tortuosity (HP:0004948)3.15757171
19Thick nail (HP:0001805)3.13407635
20Urinary glycosaminoglycan excretion (HP:0003541)3.04142968
21Mucopolysacchariduria (HP:0008155)3.04142968
22Neurofibrillary tangles (HP:0002185)3.01948809
23Osteolytic defects of the phalanges of the hand (HP:0009771)2.96545041
24Osteolytic defects of the hand bones (HP:0009699)2.96545041
25Prostate neoplasm (HP:0100787)2.95434706
26Abnormality of macrophages (HP:0004311)2.93531348
27Spondylolisthesis (HP:0003302)2.91772503
28Abnormality of glycosaminoglycan metabolism (HP:0004371)2.89831401
29Abnormality of mucopolysaccharide metabolism (HP:0011020)2.89831401
30Abnormality of polysaccharide metabolism (HP:0011012)2.89831401
31Disinhibition (HP:0000734)2.84755674
32J-shaped sella turcica (HP:0002680)2.83592491
33Hyperacusis (HP:0010780)2.76225256
34Aortic aneurysm (HP:0004942)2.71269995
35Nephritis (HP:0000123)2.70584169
36Myocardial infarction (HP:0001658)2.66426842
37Abnormality of complement system (HP:0005339)2.63528636
38Mediastinal lymphadenopathy (HP:0100721)2.62956453
39Aortic dissection (HP:0002647)2.61715791
40Agnosia (HP:0010524)2.61528041
41Natal tooth (HP:0000695)2.59561696
42Nuclear cataract (HP:0100018)2.58870474
43Urethral obstruction (HP:0000796)2.57740164
44Short nail (HP:0001799)2.57599588
45Orchitis (HP:0100796)2.56395746
46Cerebral inclusion bodies (HP:0100314)2.55255355
47Premature rupture of membranes (HP:0001788)2.54423886
48Gingivitis (HP:0000230)2.53781064
49Myositis (HP:0100614)2.46028996
50Absent frontal sinuses (HP:0002688)2.45576642
51Flat acetabular roof (HP:0003180)2.42823059
52Axonal loss (HP:0003447)2.42328080
53Thin bony cortex (HP:0002753)2.38054079
54Protrusio acetabuli (HP:0003179)2.35848063
55Periodontitis (HP:0000704)2.34780145
56Complement deficiency (HP:0004431)2.31913631
57Deformed sella turcica (HP:0002681)2.28163458
58Increased connective tissue (HP:0009025)2.21986890
59Fragile skin (HP:0001030)2.21932818
60Abnormality of the distal phalanges of the toes (HP:0010182)2.21339677
61Distal lower limb amyotrophy (HP:0008944)2.21105641
62Optic neuritis (HP:0100653)2.18214731
63Retrobulbar optic neuritis (HP:0100654)2.18214731
64Recurrent skin infections (HP:0001581)2.17296676
65Distal lower limb muscle weakness (HP:0009053)2.15809447
66Spinal cord lesions (HP:0100561)2.14946571
67Syringomyelia (HP:0003396)2.14946571
68Bladder diverticulum (HP:0000015)2.12379175
69Autoimmune thrombocytopenia (HP:0001973)2.10252672
70Achilles tendon contracture (HP:0001771)2.06519175
71Ankle contracture (HP:0006466)2.05602317
72Spinal rigidity (HP:0003306)2.04897606
73Chronic obstructive pulmonary disease (HP:0006510)2.04364323
74Obstructive lung disease (HP:0006536)2.04364323
75Wormian bones (HP:0002645)2.03918766
76Advanced eruption of teeth (HP:0006288)2.03056773
77Blue sclerae (HP:0000592)2.02481444
78Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.01718628
79Basal ganglia calcification (HP:0002135)1.99628354
80Broad face (HP:0000283)1.99593099
81Ulnar bowing (HP:0003031)1.99261962
82Shallow orbits (HP:0000586)1.97748118
83Biconcave vertebral bodies (HP:0004586)1.96801038
84Mitral valve prolapse (HP:0001634)1.95079294
85Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.94310961
86Interstitial pulmonary disease (HP:0006530)1.94022609
87Mitral stenosis (HP:0001718)1.93561314
88Pathologic fracture (HP:0002756)1.93333978
89Diminished motivation (HP:0000745)1.91610026
90Arterial thrombosis (HP:0004420)1.90576613
91Vertebral compression fractures (HP:0002953)1.90512905
92Abnormality of the frontal sinuses (HP:0002687)1.90013531
93Tetraparesis (HP:0002273)1.89999324
94Distal upper limb amyotrophy (HP:0007149)1.89650447
95Upper limb amyotrophy (HP:0009129)1.89650447
96Hepatosplenomegaly (HP:0001433)1.85761531
97Abnormality of the Achilles tendon (HP:0005109)1.84836116
98Dilatation of the ascending aorta (HP:0005111)1.82633154
99Atrophic scars (HP:0001075)1.81910580
100Osteomyelitis (HP:0002754)1.80315377
101Aneurysm (HP:0002617)1.79441935
102Upper motor neuron abnormality (HP:0002127)1.79283602
103Abnormality of the acetabulum (HP:0003170)1.78657305
104Abnormality of dentin (HP:0010299)1.78567706
105Peritonitis (HP:0002586)1.78099656
106Abnormality of the thoracic spine (HP:0100711)1.77858238
107Abnormality of the distal phalanx of the thumb (HP:0009617)1.77367070
108Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.76607945
109Retinal atrophy (HP:0001105)1.75220931
110Pustule (HP:0200039)1.74826970
111Mitral regurgitation (HP:0001653)1.73441418
112Neuronal loss in central nervous system (HP:0002529)1.73197654
113Long toe (HP:0010511)1.72827223
114Abnormality of the sella turcica (HP:0002679)1.71767010
115Abnormality of the lumbar spine (HP:0100712)1.71468490
116Premature loss of primary teeth (HP:0006323)1.70914256
117Soft skin (HP:0000977)1.70695092
118Cellulitis (HP:0100658)1.70598619
119Recurrent fungal infections (HP:0002841)1.69850842
120Neonatal short-limb short stature (HP:0008921)1.68769599
121Stomatitis (HP:0010280)1.66875998
122Insomnia (HP:0100785)1.65898140
123Protuberant abdomen (HP:0001538)1.65653689
124Skin nodule (HP:0200036)1.64754371
125Coarse hair (HP:0002208)1.63999184
126Striae distensae (HP:0001065)1.63170242
127Bone pain (HP:0002653)1.62052305
128Abnormal ossification of hand bones (HP:0005921)1.61036645
129Genu recurvatum (HP:0002816)1.61024878
130Elevated erythrocyte sedimentation rate (HP:0003565)1.60027480
131Asymmetric septal hypertrophy (HP:0001670)1.59816654
132Joint stiffness (HP:0001387)1.59677771
133Esophageal varix (HP:0002040)1.59537525
134Multiple lipomas (HP:0001012)1.59445106
135Neonatal death (HP:0003811)1.58539013
136Keratoconjunctivitis sicca (HP:0001097)1.58124867
137Broad metatarsal (HP:0001783)1.57465428
138Ovoid vertebral bodies (HP:0003300)1.57282906
139Thoracic kyphosis (HP:0002942)1.56545419
140Disproportionate tall stature (HP:0001519)1.55453686
141Abnormality of the vasculature of the conjunctiva (HP:0008054)1.54446505
142Abnormality of the peritoneum (HP:0002585)1.53824858
143Loss of speech (HP:0002371)1.52627221
144Apathy (HP:0000741)1.51595198
145Abnormality of the odontoid process (HP:0003310)1.50226099

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR25.36083070
2RIPK42.78143075
3MAP3K142.77620846
4TYK22.76015621
5BLK2.56728605
6NME22.42596925
7STK102.39914071
8IRAK32.39163154
9NEK92.17338458
10TBK12.16788736
11SMG12.14552908
12IRAK42.08649904
13GRK72.03527828
14EPHB22.03286645
15CSF1R2.02524950
16KIT1.99846370
17LATS21.97415636
18ICK1.96349725
19EEF2K1.92878271
20MOS1.87313668
21TTN1.84973944
22CAMK1D1.80950439
23PAK41.77354907
24JAK11.76486479
25TRIB31.64534980
26PRPF4B1.56984511
27PKN21.54309109
28IKBKB1.52627129
29JAK31.51147272
30TESK11.45967133
31ERN11.45416199
32CSK1.43680549
33LMTK21.42296591
34PTK61.41616354
35NTRK11.37559210
36MATK1.35900692
37MAP2K31.29888836
38CDC42BPA1.29350357
39RPS6KA41.25912951
40FGFR31.25704846
41MAP3K31.23814497
42CDK61.23633030
43FGR1.22880703
44CHUK1.20943597
45HCK1.19928646
46TRPM71.19657310
47IKBKE1.18903778
48LATS11.18777927
49BMX1.12599395
50MAP3K131.11144370
51DDR21.09113703
52RIPK11.08824134
53LIMK11.07901277
54TAOK21.07876202
55ERBB41.07231628
56PIM21.04966342
57EIF2AK21.02633099
58EPHA21.01792160
59PDGFRA1.01546304
60MTOR1.00815407
61ARAF1.00262560
62STK31.00006599
63ABL20.98784019
64SCYL20.98224025
65CAMK1G0.97539562
66JAK20.94118418
67EPHB10.90497916
68CDK120.88058561
69RPS6KA20.86544999
70FGFR40.83584315
71EPHA30.83090679
72PBK0.82826787
73CLK10.81492120
74LYN0.81351317
75MYLK0.81286702
76FER0.79482465
77MAP3K60.79097726
78PRKG20.78641076
79MST1R0.77678753
80PRKD20.74465518
81NUAK10.74076802
82ERBB30.72312012
83EGFR0.71582180
84TGFBR10.70673851
85YES10.70527641
86LCK0.70401386
87KSR20.68154563
88IGF1R0.67017089
89DMPK0.66770187
90PAK20.65360545
91FES0.65102018
92MAP3K80.63162203
93PDPK10.62599017
94ROCK20.61670301
95PLK20.60799345
96MARK30.59697623
97MAPK70.58835662
98BMPR20.58834944
99PTK2B0.57874394
100MAPKAPK20.57645671
101PDGFRB0.57528979
102FRK0.56171961
103ABL10.54341890
104CDK80.54140865
105TESK20.53817902
106CAMKK10.53661402
107MAP3K10.52919462
108ZAP700.52577786
109MAP4K10.51993496
110PTK20.50948329
111PDK20.48754770
112GSK3A0.48136114
113LRRK20.48060480
114MAPK150.47939922
115RET0.47750843
116PRKCD0.47622595
117PIM10.47333311
118INSR0.47108854
119MAP3K20.46356567
120MAP3K100.45123472
121CDK90.45043564
122MARK20.43611438
123RPS6KC10.42518673
124RPS6KL10.42518673
125TAOK10.42111790
126KSR10.41280837
127MELK0.41033130
128MET0.40767086
129PRKD30.40636265
130SGK30.40281021
131IRAK20.39224142
132ILK0.38291375
133BTK0.37829884
134ERBB20.37141992
135SRC0.37015490
136SIK10.36216551
137ITK0.34095917
138FLT30.34078586
139ROCK10.33908854
140TEC0.31791963
141STK240.30297840
142CAMK2G0.28754990
143DAPK30.28546715

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.24145879
2Glycosaminoglycan degradation_Homo sapiens_hsa005313.09309463
3Leishmaniasis_Homo sapiens_hsa051402.77000078
4Lysosome_Homo sapiens_hsa041422.30117535
5Other glycan degradation_Homo sapiens_hsa005112.25435786
6Osteoclast differentiation_Homo sapiens_hsa043802.23123475
7Toll-like receptor signaling pathway_Homo sapiens_hsa046202.18136466
8Pertussis_Homo sapiens_hsa051332.08336323
9Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.07197595
10Malaria_Homo sapiens_hsa051441.83730529
11Tuberculosis_Homo sapiens_hsa051521.82332360
12Toxoplasmosis_Homo sapiens_hsa051451.70565758
13NOD-like receptor signaling pathway_Homo sapiens_hsa046211.69163622
14Legionellosis_Homo sapiens_hsa051341.68247620
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.66346388
16Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.65340989
17Galactose metabolism_Homo sapiens_hsa000521.61050438
18Salmonella infection_Homo sapiens_hsa051321.56318644
19Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.56091512
20Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.49462070
21Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.46135078
22TNF signaling pathway_Homo sapiens_hsa046681.44825936
23Phagosome_Homo sapiens_hsa041451.44556285
24AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.41542711
25Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.41334550
26Influenza A_Homo sapiens_hsa051641.40251414
27Shigellosis_Homo sapiens_hsa051311.39933956
28B cell receptor signaling pathway_Homo sapiens_hsa046621.38990856
29Measles_Homo sapiens_hsa051621.36568098
30Adherens junction_Homo sapiens_hsa045201.34103249
31Pentose phosphate pathway_Homo sapiens_hsa000301.33872726
32Central carbon metabolism in cancer_Homo sapiens_hsa052301.31122024
33Amoebiasis_Homo sapiens_hsa051461.28615608
34Leukocyte transendothelial migration_Homo sapiens_hsa046701.27898904
35Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.27473750
36Apoptosis_Homo sapiens_hsa042101.25772971
37Vibrio cholerae infection_Homo sapiens_hsa051101.24776919
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.21890496
39Small cell lung cancer_Homo sapiens_hsa052221.20682482
40Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.20357939
41Antigen processing and presentation_Homo sapiens_hsa046121.19016810
42Fructose and mannose metabolism_Homo sapiens_hsa000511.18285650
43Chronic myeloid leukemia_Homo sapiens_hsa052201.16877218
44Pancreatic cancer_Homo sapiens_hsa052121.14367284
45Rheumatoid arthritis_Homo sapiens_hsa053231.12506513
46Proteoglycans in cancer_Homo sapiens_hsa052051.09555235
47Focal adhesion_Homo sapiens_hsa045101.08344765
48Hepatitis B_Homo sapiens_hsa051611.07589669
49Graft-versus-host disease_Homo sapiens_hsa053321.05395170
50ECM-receptor interaction_Homo sapiens_hsa045121.05050955
51Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.04271446
52Chemokine signaling pathway_Homo sapiens_hsa040621.03046420
53African trypanosomiasis_Homo sapiens_hsa051431.02934146
54Platelet activation_Homo sapiens_hsa046111.02849663
55Hematopoietic cell lineage_Homo sapiens_hsa046401.01531658
56Herpes simplex infection_Homo sapiens_hsa051681.00075146
57Complement and coagulation cascades_Homo sapiens_hsa046100.97880373
58Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.97764191
59RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.96933372
60Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.96603640
61Prion diseases_Homo sapiens_hsa050200.96434287
62MicroRNAs in cancer_Homo sapiens_hsa052060.94850030
63Viral myocarditis_Homo sapiens_hsa054160.94695143
64Thyroid cancer_Homo sapiens_hsa052160.91186132
65Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.90758994
66Jak-STAT signaling pathway_Homo sapiens_hsa046300.90129927
67* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.89380929
68Hepatitis C_Homo sapiens_hsa051600.89208179
69PPAR signaling pathway_Homo sapiens_hsa033200.87468092
70Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.84438993
71Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.80407891
72Endometrial cancer_Homo sapiens_hsa052130.79430030
73Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.79227828
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.78634010
75Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.77605190
76Allograft rejection_Homo sapiens_hsa053300.77543852
77Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.74292597
78Transcriptional misregulation in cancer_Homo sapiens_hsa052020.71129579
79Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70509458
80Intestinal immune network for IgA production_Homo sapiens_hsa046720.70065179
81Dorso-ventral axis formation_Homo sapiens_hsa043200.69901837
82Estrogen signaling pathway_Homo sapiens_hsa049150.68031099
83Notch signaling pathway_Homo sapiens_hsa043300.67564091
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67320311
85TGF-beta signaling pathway_Homo sapiens_hsa043500.66832571
86Phospholipase D signaling pathway_Homo sapiens_hsa040720.65691995
87Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65607105
88Biosynthesis of amino acids_Homo sapiens_hsa012300.64436982
89HIF-1 signaling pathway_Homo sapiens_hsa040660.64185841
90Glioma_Homo sapiens_hsa052140.63598224
91Mineral absorption_Homo sapiens_hsa049780.62917762
92Asthma_Homo sapiens_hsa053100.62798978
93Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.61493340
94Rap1 signaling pathway_Homo sapiens_hsa040150.61097506
95Sulfur metabolism_Homo sapiens_hsa009200.60795480
96Tight junction_Homo sapiens_hsa045300.60637149
97GnRH signaling pathway_Homo sapiens_hsa049120.59841598
98Endocytosis_Homo sapiens_hsa041440.59717727
99Melanoma_Homo sapiens_hsa052180.59455408
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.58424413
101Prostate cancer_Homo sapiens_hsa052150.58132046
102HTLV-I infection_Homo sapiens_hsa051660.58058225
103Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.58045415
104Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.57508194
105Insulin signaling pathway_Homo sapiens_hsa049100.57155029
106Acute myeloid leukemia_Homo sapiens_hsa052210.56439922
107ErbB signaling pathway_Homo sapiens_hsa040120.56342356
108Protein digestion and absorption_Homo sapiens_hsa049740.56121480
109Carbon metabolism_Homo sapiens_hsa012000.55966428
110Viral carcinogenesis_Homo sapiens_hsa052030.55561238
111Renal cell carcinoma_Homo sapiens_hsa052110.53987067
112Glutathione metabolism_Homo sapiens_hsa004800.53784174
113Colorectal cancer_Homo sapiens_hsa052100.53592187
1142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.52179138
115Caffeine metabolism_Homo sapiens_hsa002320.50770853
116Pathways in cancer_Homo sapiens_hsa052000.50760996
117N-Glycan biosynthesis_Homo sapiens_hsa005100.49269382
118Steroid biosynthesis_Homo sapiens_hsa001000.48476596
119Prolactin signaling pathway_Homo sapiens_hsa049170.47961058
120Adipocytokine signaling pathway_Homo sapiens_hsa049200.47916479
121Dilated cardiomyopathy_Homo sapiens_hsa054140.46593296
122VEGF signaling pathway_Homo sapiens_hsa043700.46150197
123Vitamin B6 metabolism_Homo sapiens_hsa007500.44315567
124Renin-angiotensin system_Homo sapiens_hsa046140.43477024
125mTOR signaling pathway_Homo sapiens_hsa041500.42403355
126Gap junction_Homo sapiens_hsa045400.42206373
127Bladder cancer_Homo sapiens_hsa052190.41487450
128FoxO signaling pathway_Homo sapiens_hsa040680.40773265
129Sphingolipid metabolism_Homo sapiens_hsa006000.40589939
130Non-small cell lung cancer_Homo sapiens_hsa052230.40530661
131p53 signaling pathway_Homo sapiens_hsa041150.40349931
132Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.39090734
133Epstein-Barr virus infection_Homo sapiens_hsa051690.38429893
134PI3K-Akt signaling pathway_Homo sapiens_hsa041510.37290434
135Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.37273479

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