CYFIP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.25517135
2locomotory exploration behavior (GO:0035641)6.20771439
3synaptic vesicle maturation (GO:0016188)6.20707500
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.79846257
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.57967510
6synaptic vesicle exocytosis (GO:0016079)5.57126265
7positive regulation of gamma-delta T cell activation (GO:0046645)5.40176503
8glutamate secretion (GO:0014047)5.31897651
9regulation of synaptic vesicle exocytosis (GO:2000300)5.28313675
10synaptic vesicle docking involved in exocytosis (GO:0016081)5.26446191
11negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.25055513
12negative regulation of cell killing (GO:0031342)5.25055513
13vocalization behavior (GO:0071625)5.18957587
14regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.12797205
15negative T cell selection (GO:0043383)5.05749598
16negative thymic T cell selection (GO:0045060)4.97902893
17regulation of B cell receptor signaling pathway (GO:0050855)4.97552973
18regulation of glutamate receptor signaling pathway (GO:1900449)4.89755433
19positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.83812439
20regulation of synaptic vesicle transport (GO:1902803)4.71508041
21ionotropic glutamate receptor signaling pathway (GO:0035235)4.65896608
22activated T cell proliferation (GO:0050798)4.65730096
23neuronal action potential propagation (GO:0019227)4.63734050
24exploration behavior (GO:0035640)4.58703128
25neurotransmitter secretion (GO:0007269)4.53299903
26regulation of neuronal synaptic plasticity (GO:0048168)4.52841798
27positive T cell selection (GO:0043368)4.49198878
28regulation of long-term neuronal synaptic plasticity (GO:0048169)4.47813499
29protein localization to synapse (GO:0035418)4.43139740
30positive thymic T cell selection (GO:0045059)4.32793565
31regulation of synapse structural plasticity (GO:0051823)4.23339110
32regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.19296730
33response to interleukin-15 (GO:0070672)4.17681608
34B cell receptor signaling pathway (GO:0050853)4.14601728
35synaptic transmission, glutamatergic (GO:0035249)4.13883915
36cellular potassium ion homeostasis (GO:0030007)4.12778460
37cellular response to interleukin-15 (GO:0071350)4.11066933
38neuron cell-cell adhesion (GO:0007158)4.08923743
39regulation of gamma-delta T cell differentiation (GO:0045586)4.07434048
40glutamate receptor signaling pathway (GO:0007215)4.07378400
41long-term memory (GO:0007616)4.07065556
42thymic T cell selection (GO:0045061)4.05460881
43antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.00675968
44T cell selection (GO:0045058)3.98863107
45positive regulation of membrane potential (GO:0045838)3.95994860
46sodium ion export (GO:0071436)3.94619973
47neuron-neuron synaptic transmission (GO:0007270)3.94242059
48layer formation in cerebral cortex (GO:0021819)3.92593856
49G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.92465047
50membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.90967508
51regulation of excitatory postsynaptic membrane potential (GO:0060079)3.88436803
52regulation of gamma-delta T cell activation (GO:0046643)3.86394792
53dendritic spine morphogenesis (GO:0060997)3.85921233
54neurotransmitter-gated ion channel clustering (GO:0072578)3.82641376
55activation of protein kinase A activity (GO:0034199)3.72190862
56gamma-aminobutyric acid transport (GO:0015812)3.72167969
57regulation of synaptic plasticity (GO:0048167)3.71740790
58antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.71360792
59antigen processing and presentation of endogenous antigen (GO:0019883)3.70616683
60proline transport (GO:0015824)3.70310361
61regulation of postsynaptic membrane potential (GO:0060078)3.67901719
62leukocyte aggregation (GO:0070486)3.65077618
63long-term synaptic potentiation (GO:0060291)3.63322088
64cerebellar Purkinje cell differentiation (GO:0021702)3.60558133
65neurotransmitter transport (GO:0006836)3.59872516
66regulation of isotype switching to IgG isotypes (GO:0048302)3.54437043
67regulation of dendritic spine morphogenesis (GO:0061001)3.54399382
68regulation of ARF protein signal transduction (GO:0032012)3.54243850
69positive regulation of synapse maturation (GO:0090129)3.53000733
70positive regulation of granulocyte differentiation (GO:0030854)3.47984059
71synaptic vesicle endocytosis (GO:0048488)3.45567483
72neuromuscular process controlling balance (GO:0050885)3.44603282
73regulation of neurotransmitter secretion (GO:0046928)3.43916550
74T cell migration (GO:0072678)3.43485827
75gamma-aminobutyric acid signaling pathway (GO:0007214)3.40049944
76regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.39910058
77positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.39358308
78positive regulation of Rap GTPase activity (GO:0032854)3.38353340
79positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.36760794
80antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.34681553
81negative regulation of T cell mediated immunity (GO:0002710)3.34661732
82regulation of neurotransmitter levels (GO:0001505)3.34015492
83negative regulation of lymphocyte mediated immunity (GO:0002707)3.33250654
84positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.32030147
85cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.31775977
86regulation of synaptic transmission, glutamatergic (GO:0051966)3.31055556
87transmission of nerve impulse (GO:0019226)3.29930229
88prepulse inhibition (GO:0060134)3.28902148
89positive regulation of neurotransmitter secretion (GO:0001956)3.25388356
90positive regulation of synaptic transmission, GABAergic (GO:0032230)3.25043614
91regulation of vesicle fusion (GO:0031338)3.23928330
92membrane depolarization during action potential (GO:0086010)3.23846971
93neuromuscular process controlling posture (GO:0050884)3.22960073
94vesicle transport along microtubule (GO:0047496)3.21550721
95regulation of B cell differentiation (GO:0045577)3.20233183
96cerebellar granule cell differentiation (GO:0021707)3.19910314
97positive regulation of neurotransmitter transport (GO:0051590)3.19119147
98membrane depolarization (GO:0051899)3.17865274
99chemosensory behavior (GO:0007635)3.16864699
100regulation of neurotransmitter transport (GO:0051588)3.16504194
101negative regulation of synaptic transmission, GABAergic (GO:0032229)3.16409357
102positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.14507870
103regulation of Rap GTPase activity (GO:0032317)3.13974214
104auditory behavior (GO:0031223)3.12816497
105neuron recognition (GO:0008038)3.10613284
106positive regulation of B cell differentiation (GO:0045579)3.08464817
107cell communication by electrical coupling (GO:0010644)3.06873840
108mast cell activation (GO:0045576)3.06382854
109membrane hyperpolarization (GO:0060081)3.05494701
110potassium ion import (GO:0010107)3.04120292
111antigen receptor-mediated signaling pathway (GO:0050851)3.03750258
112positive regulation of synaptic transmission (GO:0050806)3.02929506
113mucosal-associated lymphoid tissue development (GO:0048537)3.01735804
114Peyers patch development (GO:0048541)3.01735804
115glycine transport (GO:0015816)3.01425905
116long term synaptic depression (GO:0060292)3.00303059
117response to auditory stimulus (GO:0010996)3.00264733
118negative regulation of leukocyte mediated immunity (GO:0002704)3.00100367
119response to histamine (GO:0034776)2.99256921
120regulation of synaptic transmission (GO:0050804)2.98635942
121learning (GO:0007612)2.98556188
122G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.97154669
123mast cell activation involved in immune response (GO:0002279)2.95598533
124mast cell degranulation (GO:0043303)2.95598533
125L-amino acid import (GO:0043092)2.95530122
126intraspecies interaction between organisms (GO:0051703)2.95389684
127social behavior (GO:0035176)2.95389684
128innervation (GO:0060384)2.94906820
129synaptic transmission (GO:0007268)2.94240617
130regulation of dendritic spine development (GO:0060998)2.93576601
131dendrite morphogenesis (GO:0048813)2.93176916
132interferon-gamma production (GO:0032609)2.93020703
133negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.92453631
134neuronal ion channel clustering (GO:0045161)2.92019206
135dendritic spine organization (GO:0097061)2.91867243
136regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.91374348
137behavioral defense response (GO:0002209)2.90927948
138behavioral fear response (GO:0001662)2.90927948
139positive regulation of dendritic spine morphogenesis (GO:0061003)2.88571652
140detection of calcium ion (GO:0005513)2.87231329
141regulation of voltage-gated calcium channel activity (GO:1901385)2.87018333
142axonal fasciculation (GO:0007413)2.85660711
143T cell receptor signaling pathway (GO:0050852)2.75601981
144T cell homeostasis (GO:0043029)2.73950088
145tolerance induction (GO:0002507)2.69643918
146amino acid import (GO:0043090)2.68892375
147regulation of alpha-beta T cell proliferation (GO:0046640)2.62508811
148signal complex assembly (GO:0007172)2.61487599
149phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.60990920
150negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.60507300
151natural killer cell differentiation (GO:0001779)2.53474214
152regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.51773757
153regulation of defense response to virus by virus (GO:0050690)2.51597396
154negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.51174711

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.46876396
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.43317546
3RARB_27405468_Chip-Seq_BRAIN_Mouse3.22426068
4RUNX_20019798_ChIP-Seq_JUKART_Human3.21521506
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.15018572
6GBX2_23144817_ChIP-Seq_PC3_Human3.07794235
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.01818612
8REST_21632747_ChIP-Seq_MESCs_Mouse3.00647221
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.94665431
10DROSHA_22980978_ChIP-Seq_HELA_Human2.92117122
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.91371146
12MYC_22102868_ChIP-Seq_BL_Human2.72704997
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.59447052
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.59447052
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.51840175
16REST_18959480_ChIP-ChIP_MESCs_Mouse2.50987593
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.50468283
18* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.49518520
19IKZF1_21737484_ChIP-ChIP_HCT116_Human2.48418853
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.47419637
21* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.35119637
22* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.31440287
23EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.29500552
24SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.29479181
25* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.27824047
26MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.27361016
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.26572161
28* MYB_26560356_Chip-Seq_TH2_Human2.21506558
29* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.20690230
30EZH2_27304074_Chip-Seq_ESCs_Mouse2.14677911
31EZH2_27294783_Chip-Seq_ESCs_Mouse2.14219145
32RNF2_27304074_Chip-Seq_ESCs_Mouse2.13236476
33IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.07895616
34CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.99644384
35* MAF_26560356_Chip-Seq_TH1_Human1.95414087
36KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.90549415
37* UTX_26944678_Chip-Seq_JUKART_Human1.88948993
38ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.87407597
39IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.86773611
40EED_16625203_ChIP-ChIP_MESCs_Mouse1.84260723
41SCL_19346495_ChIP-Seq_HPC-7_Human1.84160213
42STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.82313121
43THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.78666239
44AR_21572438_ChIP-Seq_LNCaP_Human1.78637340
45* GATA3_27048872_Chip-Seq_THYMUS_Human1.74739400
46NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.71592693
47TCF7_22412390_ChIP-Seq_EML_Mouse1.71132985
48VDR_21846776_ChIP-Seq_THP-1_Human1.70030121
49SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.69427277
50* MYB_26560356_Chip-Seq_TH1_Human1.68011000
51* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.65827720
52IRF8_21731497_ChIP-ChIP_J774_Mouse1.65436163
53RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.63063921
54CIITA_25753668_ChIP-Seq_RAJI_Human1.62035985
55MAF_26560356_Chip-Seq_TH2_Human1.62026346
56BP1_19119308_ChIP-ChIP_Hs578T_Human1.57255925
57* SMAD4_21799915_ChIP-Seq_A2780_Human1.55178584
58KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.50549971
59CTBP2_25329375_ChIP-Seq_LNCAP_Human1.48951403
60* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.48875541
61DNAJC2_21179169_ChIP-ChIP_NT2_Human1.48512284
62VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.44367108
63CTBP1_25329375_ChIP-Seq_LNCAP_Human1.42073351
64SMAD_19615063_ChIP-ChIP_OVARY_Human1.41542790
65GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.41328505
66RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.41225158
67ERG_21242973_ChIP-ChIP_JURKAT_Human1.41059373
68GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.39669320
69TAF15_26573619_Chip-Seq_HEK293_Human1.38511261
70* SPI1_23127762_ChIP-Seq_K562_Human1.38371124
71* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.38233255
72NR3C1_23031785_ChIP-Seq_PC12_Mouse1.37614989
73* GATA1_19941827_ChIP-Seq_MEL_Mouse1.36614778
74KDM2B_26808549_Chip-Seq_K562_Human1.35649293
75SOX2_21211035_ChIP-Seq_LN229_Gbm1.34682411
76EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.31632871
77TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.30174595
78MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.30118466
79IRF8_27001747_Chip-Seq_BMDM_Mouse1.30084616
80* AR_19668381_ChIP-Seq_PC3_Human1.29105399
81VDR_24763502_ChIP-Seq_THP-1_Human1.26535080
82PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.26163718
83ZNF274_21170338_ChIP-Seq_K562_Hela1.25246473
84STAT4_19710469_ChIP-ChIP_TH1__Mouse1.24834810
85* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.23461611
86WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.23167731
87RING1B_27294783_Chip-Seq_ESCs_Mouse1.23035629
88STAT3_23295773_ChIP-Seq_U87_Human1.20815492
89TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.19443148
90ZFP281_18757296_ChIP-ChIP_E14_Mouse1.18183299
91* RUNX1_22412390_ChIP-Seq_EML_Mouse1.17806183
92SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16932714
93AR_25329375_ChIP-Seq_VCAP_Human1.15960632
94LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.15008991
95KDM2B_26808549_Chip-Seq_SUP-B15_Human1.12943192
96P300_19829295_ChIP-Seq_ESCs_Human1.11910576
97TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11433510
98SMAD3_21741376_ChIP-Seq_EPCs_Human1.11317986
99P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09968166
100GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07803337
101TCF4_23295773_ChIP-Seq_U87_Human1.07506781
102BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.06712746
103YAP1_20516196_ChIP-Seq_MESCs_Mouse1.06044931
104OCT4_19829295_ChIP-Seq_ESCs_Human1.04885970
105PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.03603444
106LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.03379679
107ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02937963
108CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.02886121
109TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.02849428
110* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.01869330
111* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99964988
112PRDM14_20953172_ChIP-Seq_ESCs_Human0.99813072
113* GATA3_26560356_Chip-Seq_TH2_Human0.99290884
114SMAD3_21741376_ChIP-Seq_ESCs_Human0.99210970
115RING1B_27294783_Chip-Seq_NPCs_Mouse0.99004614
116DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.98980107
117SPI1_23547873_ChIP-Seq_NB4_Human0.98688464
118RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.98470139
119ARNT_22903824_ChIP-Seq_MCF-7_Human0.98098508
120ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.97984901
121* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.97854008
122SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97765145
123TOP2B_26459242_ChIP-Seq_MCF-7_Human0.96091915
124ZFP57_27257070_Chip-Seq_ESCs_Mouse0.95039077
125RXR_22108803_ChIP-Seq_LS180_Human0.93879792
126MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93094429
127AHR_22903824_ChIP-Seq_MCF-7_Human0.92909830
128PU.1_20513432_ChIP-Seq_Bcells_Mouse0.92454019
129NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.92088684
130KDM2B_26808549_Chip-Seq_DND41_Human0.91251251
131RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89245655
132KDM2B_26808549_Chip-Seq_JURKAT_Human0.88439503
133RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.87411260
134PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.87387953
135SMAD4_21741376_ChIP-Seq_HESCs_Human0.87184271
136* TET1_21490601_ChIP-Seq_MESCs_Mouse0.86715182
137* SMC4_20622854_ChIP-Seq_HELA_Human0.86288700
138SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.86179024
139SMAD3_21741376_ChIP-Seq_HESCs_Human0.85356590
140TP53_16413492_ChIP-PET_HCT116_Human0.85038993
141CTNNB1_20460455_ChIP-Seq_HCT116_Human0.84905990
142IGF1R_20145208_ChIP-Seq_DFB_Human0.84083362
143TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.83829603
144NR3C1_21868756_ChIP-Seq_MCF10A_Human0.83125640
145RUNX2_22187159_ChIP-Seq_PCA_Human0.82709697
146SMRT_27268052_Chip-Seq_Bcells_Human0.82246476
147LXR_22292898_ChIP-Seq_THP-1_Human0.82095603
148* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.81214411
149PIAS1_25552417_ChIP-Seq_VCAP_Human0.80991213
150MYB_21317192_ChIP-Seq_ERMYB_Mouse0.80784566
151CTCF_27219007_Chip-Seq_Bcells_Human0.79832296

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.97166627
2MP0003880_abnormal_central_pattern4.64019995
3MP0003635_abnormal_synaptic_transmissio4.32130543
4MP0004270_analgesia3.69038060
5MP0009745_abnormal_behavioral_response3.49675937
6MP0002063_abnormal_learning/memory/cond3.40630975
7MP0002064_seizures3.26304486
8MP0003763_abnormal_thymus_physiology3.16884831
9MP0009046_muscle_twitch3.08877644
10MP0002822_catalepsy3.07312874
11MP0001968_abnormal_touch/_nociception3.03173253
12MP0002572_abnormal_emotion/affect_behav2.81794450
13MP0005423_abnormal_somatic_nervous2.74233785
14MP0002272_abnormal_nervous_system2.62521220
15MP0005671_abnormal_response_to2.62407096
16MP0002734_abnormal_mechanical_nocicepti2.52204904
17MP0001486_abnormal_startle_reflex2.47715170
18MP0001501_abnormal_sleep_pattern2.35033735
19MP0001800_abnormal_humoral_immune2.34046475
20MP0008569_lethality_at_weaning2.25341815
21MP0002736_abnormal_nociception_after2.24842678
22MP0002909_abnormal_adrenal_gland2.23402748
23MP0001835_abnormal_antigen_presentation2.23218990
24MP0009780_abnormal_chondrocyte_physiolo2.18401379
25MP0002735_abnormal_chemical_nociception2.13978948
26MP0005000_abnormal_immune_tolerance1.99461399
27MP0001440_abnormal_grooming_behavior1.97785487
28MP0002067_abnormal_sensory_capabilities1.97057712
29MP0002733_abnormal_thermal_nociception1.96692232
30MP0001970_abnormal_pain_threshold1.96139063
31MP0003436_decreased_susceptibility_to1.93075622
32MP0004811_abnormal_neuron_physiology1.85506625
33MP0003724_increased_susceptibility_to1.84625186
34MP0001790_abnormal_immune_system1.80592869
35MP0005387_immune_system_phenotype1.80592869
36MP0003787_abnormal_imprinting1.80021005
37MP0005646_abnormal_pituitary_gland1.79075151
38MP0003329_amyloid_beta_deposits1.77868177
39MP0002420_abnormal_adaptive_immunity1.76340648
40MP0005386_behavior/neurological_phenoty1.74834657
41MP0004924_abnormal_behavior1.74834657
42MP0002723_abnormal_immune_serum1.73617849
43MP0001819_abnormal_immune_cell1.71951208
44MP0003879_abnormal_hair_cell1.70738795
45MP0000685_abnormal_immune_system1.69657498
46MP0002557_abnormal_social/conspecific_i1.69059657
47MP0000703_abnormal_thymus_morphology1.68849628
48MP0002398_abnormal_bone_marrow1.68794900
49MP0002184_abnormal_innervation1.66981189
50MP0004858_abnormal_nervous_system1.60825811
51MP0001986_abnormal_taste_sensitivity1.59918680
52MP0001984_abnormal_olfaction1.52854661
53MP0002452_abnormal_antigen_presenting1.51577888
54MP0003866_abnormal_defecation1.49248967
55MP0000716_abnormal_immune_system1.47516426
56MP0003633_abnormal_nervous_system1.46710092
57MP0004885_abnormal_endolymph1.46597488
58MP0000955_abnormal_spinal_cord1.46321666
59MP0008961_abnormal_basal_metabolism1.42689206
60MP0005645_abnormal_hypothalamus_physiol1.42165432
61MP0000778_abnormal_nervous_system1.41609962
62MP0005025_abnormal_response_to1.41143430
63MP0002066_abnormal_motor_capabilities/c1.39614085
64MP0002882_abnormal_neuron_morphology1.31997059
65MP0000569_abnormal_digit_pigmentation1.30310221
66MP0000689_abnormal_spleen_morphology1.28310135
67MP0003300_gastrointestinal_ulcer1.27286927
68MP0001502_abnormal_circadian_rhythm1.26680624
69MP0002722_abnormal_immune_system1.26571758
70MP0006276_abnormal_autonomic_nervous1.25044459
71MP0008877_abnormal_DNA_methylation1.23029328
72MP0001529_abnormal_vocalization1.20754345
73MP0003631_nervous_system_phenotype1.16617698
74MP0002405_respiratory_system_inflammati1.16004940
75MP0002419_abnormal_innate_immunity1.15098204
76MP0002009_preneoplasia1.14871489
77MP0001905_abnormal_dopamine_level1.11259382
78MP0009278_abnormal_bone_marrow1.11039673
79MP0008872_abnormal_physiological_respon1.09499916
80MP0008874_decreased_physiological_sensi1.09022825
81MP0004381_abnormal_hair_follicle1.08708546
82MP0002429_abnormal_blood_cell1.07130237
83MP0003172_abnormal_lysosome_physiology1.06754767
84MP0000013_abnormal_adipose_tissue1.06735676
85MP0004142_abnormal_muscle_tone1.04505333
86MP0009785_altered_susceptibility_to1.02790988
87MP0004510_myositis1.02648969
88MP0002152_abnormal_brain_morphology1.02286783
89MP0002396_abnormal_hematopoietic_system1.00654044
90MP0003075_altered_response_to0.98996037
91MP0002229_neurodegeneration0.95375432
92MP0002069_abnormal_eating/drinking_beha0.95087816
93MP0006082_CNS_inflammation0.94034332
94MP0003183_abnormal_peptide_metabolism0.93033248
95MP0005535_abnormal_body_temperature0.93001317
96MP0004043_abnormal_pH_regulation0.92684797
97MP0003122_maternal_imprinting0.91830628
98MP0009333_abnormal_splenocyte_physiolog0.90544761
99MP0004145_abnormal_muscle_electrophysio0.90482720
100MP0001348_abnormal_lacrimal_gland0.90139126
101MP0005075_abnormal_melanosome_morpholog0.89245852
102MP0010155_abnormal_intestine_physiology0.86742914
103MP0004130_abnormal_muscle_cell0.86561843
104MP0000465_gastrointestinal_hemorrhage0.86335467
105MP0002166_altered_tumor_susceptibility0.85835225
106MP0005499_abnormal_olfactory_system0.85272262
107MP0005394_taste/olfaction_phenotype0.85272262
108MP0003283_abnormal_digestive_organ0.84914595
109MP0004742_abnormal_vestibular_system0.84378189
110MP0010386_abnormal_urinary_bladder0.83726025
111MP0002928_abnormal_bile_duct0.83038330
112MP0003121_genomic_imprinting0.82770390
113MP0000604_amyloidosis0.80830956
114MP0008260_abnormal_autophagy0.80458043
115MP0000920_abnormal_myelination0.79958366
116MP0002132_abnormal_respiratory_system0.79580120
117MP0001177_atelectasis0.74925114
118MP0003690_abnormal_glial_cell0.74887511
119MP0004085_abnormal_heartbeat0.73759042
120MP0010234_abnormal_vibrissa_follicle0.73432571
121MP0005551_abnormal_eye_electrophysiolog0.73383554
122MP0003634_abnormal_glial_cell0.72227528
123MP0000631_abnormal_neuroendocrine_gland0.70396270
124MP0000751_myopathy0.70252230
125MP0003632_abnormal_nervous_system0.69974787
126MP0001963_abnormal_hearing_physiology0.69364086
127MP0001188_hyperpigmentation0.68351046
128MP0005409_darkened_coat_color0.67495763
129MP0002837_dystrophic_cardiac_calcinosis0.64162100
130MP0003303_peritoneal_inflammation0.63113605
131MP0001765_abnormal_ion_homeostasis0.62977744
132MP0002090_abnormal_vision0.61742626
133MP0004484_altered_response_of0.60796203
134MP0004215_abnormal_myocardial_fiber0.57058536
135MP0001485_abnormal_pinna_reflex0.56288113
136MP0005310_abnormal_salivary_gland0.55425157
137MP0002693_abnormal_pancreas_physiology0.54721041
138MP0005167_abnormal_blood-brain_barrier0.54411085
139MP0004233_abnormal_muscle_weight0.54241307
140MP0001664_abnormal_digestion0.53805008
141MP0010769_abnormal_survival0.53492990
142MP0002752_abnormal_somatic_nervous0.53421522
143MP0003956_abnormal_body_size0.52723448
144MP0003045_fibrosis0.52550802

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.61439268
2Myokymia (HP:0002411)6.74618426
3Focal seizures (HP:0007359)5.80822825
4Visual hallucinations (HP:0002367)5.55747191
5Atonic seizures (HP:0010819)4.64803378
6Epileptic encephalopathy (HP:0200134)4.57653020
7Febrile seizures (HP:0002373)4.44734172
8Panhypogammaglobulinemia (HP:0003139)4.25925813
9Absence seizures (HP:0002121)4.22081026
10Progressive cerebellar ataxia (HP:0002073)4.16984928
11Action tremor (HP:0002345)4.06548012
12Papilledema (HP:0001085)3.98285805
13T lymphocytopenia (HP:0005403)3.91016216
14Dialeptic seizures (HP:0011146)3.80452053
15Generalized tonic-clonic seizures (HP:0002069)3.74308712
16Agammaglobulinemia (HP:0004432)3.62080180
17Supranuclear gaze palsy (HP:0000605)3.61128875
18Poor eye contact (HP:0000817)3.60956727
19Eczematoid dermatitis (HP:0000976)3.58668307
20Severe combined immunodeficiency (HP:0004430)3.56853664
21Broad-based gait (HP:0002136)3.55879541
22Gaze-evoked nystagmus (HP:0000640)3.48161040
23Abnormality of T cell number (HP:0011839)3.47988288
24Depression (HP:0000716)3.47277063
25Truncal ataxia (HP:0002078)3.42502149
26Impaired vibration sensation in the lower limbs (HP:0002166)3.41468342
27Ankle clonus (HP:0011448)3.37002442
28Impaired smooth pursuit (HP:0007772)3.34698240
29Meningitis (HP:0001287)3.30261431
30Impaired social interactions (HP:0000735)3.29713457
31Abnormal social behavior (HP:0012433)3.29713457
32Dysdiadochokinesis (HP:0002075)3.17544578
33Recurrent fungal infections (HP:0002841)3.17438160
34Postural instability (HP:0002172)3.14594080
35Dysmetria (HP:0001310)3.14408391
36Urinary bladder sphincter dysfunction (HP:0002839)3.11610338
37Abnormal delayed hypersensitivity skin test (HP:0002963)3.05662479
38Anxiety (HP:0000739)3.01603315
39Myositis (HP:0100614)2.96528118
40Dysmetric saccades (HP:0000641)2.92199367
41Hypokalemic alkalosis (HP:0001949)2.91049309
42Hyperventilation (HP:0002883)2.90810556
43Abnormal eating behavior (HP:0100738)2.87224109
44Abnormality of ocular smooth pursuit (HP:0000617)2.85955524
45Amblyopia (HP:0000646)2.84425708
46Abnormality of T cells (HP:0002843)2.82539528
47Urinary urgency (HP:0000012)2.81298695
48Retrobulbar optic neuritis (HP:0100654)2.81215140
49Optic neuritis (HP:0100653)2.81215140
50Metabolic alkalosis (HP:0200114)2.80660590
51Scanning speech (HP:0002168)2.80477090
52Encephalitis (HP:0002383)2.79495925
53Hemiplegia (HP:0002301)2.78027749
54Hypoplasia of the thymus (HP:0000778)2.77771710
55Abnormality of the lower motor neuron (HP:0002366)2.73656492
56Recurrent viral infections (HP:0004429)2.73564530
57Stereotypic behavior (HP:0000733)2.73219094
58Genetic anticipation (HP:0003743)2.73132102
59Diplopia (HP:0000651)2.70582676
60Abnormality of binocular vision (HP:0011514)2.70582676
61Combined immunodeficiency (HP:0005387)2.63806070
62Recurrent bacterial skin infections (HP:0005406)2.62354436
63Spastic gait (HP:0002064)2.61905260
64Stomatitis (HP:0010280)2.59101242
65Intention tremor (HP:0002080)2.58978104
66Mutism (HP:0002300)2.56536307
67Elevated erythrocyte sedimentation rate (HP:0003565)2.53781251
68Excessive salivation (HP:0003781)2.50450094
69Drooling (HP:0002307)2.50450094
70Bradykinesia (HP:0002067)2.49501794
71Recurrent cutaneous fungal infections (HP:0011370)2.48460346
72Chronic mucocutaneous candidiasis (HP:0002728)2.48460346
73Lymphopenia (HP:0001888)2.48163698
74Mediastinal lymphadenopathy (HP:0100721)2.48153444
75IgG deficiency (HP:0004315)2.45868221
76Annular pancreas (HP:0001734)2.45705303
77Epileptiform EEG discharges (HP:0011182)2.45498075
78Ventricular fibrillation (HP:0001663)2.44180973
79Slow saccadic eye movements (HP:0000514)2.43917952
80B lymphocytopenia (HP:0010976)2.42281598
81Pointed chin (HP:0000307)2.41489414
82Orchitis (HP:0100796)2.40075707
83Recurrent bronchitis (HP:0002837)2.39487751
84Cellulitis (HP:0100658)2.38317255
85Vasculitis (HP:0002633)2.38255665
86Progressive inability to walk (HP:0002505)2.37442295
87Abnormality of B cell number (HP:0010975)2.36207020
88Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.34872399
89EEG with generalized epileptiform discharges (HP:0011198)2.34859690
90Torticollis (HP:0000473)2.34743978
91Recurrent abscess formation (HP:0002722)2.34336539
92Peripheral hypomyelination (HP:0007182)2.34047108
93Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.33121594
94Abnormality of eosinophils (HP:0001879)2.32613422
95IgM deficiency (HP:0002850)2.32422188
96Granulocytopenia (HP:0001913)2.30737552
97Resting tremor (HP:0002322)2.27205681
98Hemiparesis (HP:0001269)2.27129726
99Impaired vibratory sensation (HP:0002495)2.26289881
100Eosinophilia (HP:0001880)2.25437141
101Hypsarrhythmia (HP:0002521)2.23295625
102Focal dystonia (HP:0004373)2.22755635
103Papilloma (HP:0012740)2.22663618
104Verrucae (HP:0200043)2.22663618
105Thyroiditis (HP:0100646)2.22299700
106Abnormality of cells of the lymphoid lineage (HP:0012140)2.21007495
107Limb dystonia (HP:0002451)2.20044477
108Increased IgE level (HP:0003212)2.18777193
109Inflammation of the large intestine (HP:0002037)2.16905872
110Insomnia (HP:0100785)2.16900494
111Gastrointestinal inflammation (HP:0004386)2.16447865
112Colitis (HP:0002583)2.13762278
113Hypomagnesemia (HP:0002917)2.13506173
114Ankyloglossia (HP:0010296)2.11717342
115Status epilepticus (HP:0002133)2.10674263
116Megalencephaly (HP:0001355)2.09999747
117Absent speech (HP:0001344)2.09294151
118Leukocytosis (HP:0001974)2.08698549
119Bundle branch block (HP:0011710)2.07438051
120Abnormality of saccadic eye movements (HP:0000570)2.07020857
121Recurrent sinusitis (HP:0011108)2.06285388
122Sepsis (HP:0100806)2.05011084
123Agitation (HP:0000713)2.04496883
124Recurrent skin infections (HP:0001581)2.03985855
125Cerebral inclusion bodies (HP:0100314)2.03266537
126Abnormality of the fingertips (HP:0001211)2.03260444
127Increased circulating renin level (HP:0000848)2.02799494
128Gait ataxia (HP:0002066)2.01864300
129Tetraplegia (HP:0002445)2.01624284
130Stomach cancer (HP:0012126)2.01303770
131Insidious onset (HP:0003587)2.01138393
132Termporal pattern (HP:0011008)2.01138393
133Psychosis (HP:0000709)1.97774529
134Lower limb asymmetry (HP:0100559)1.97391593
135Spinal canal stenosis (HP:0003416)1.97015826
136Pheochromocytoma (HP:0002666)1.96462316
137Lower limb muscle weakness (HP:0007340)1.95242699
138Gastrointestinal stroma tumor (HP:0100723)1.94975647
139Gastrointestinal infarctions (HP:0005244)1.92610255
140Craniofacial dystonia (HP:0012179)1.91839556
141Fetal akinesia sequence (HP:0001989)1.90691449
142Amyotrophic lateral sclerosis (HP:0007354)1.89775169
143Keratoconjunctivitis sicca (HP:0001097)1.88934218
144Clonus (HP:0002169)1.88302031
145Macroorchidism (HP:0000053)1.87812015
146Neuronal loss in central nervous system (HP:0002529)1.87694296
147Memory impairment (HP:0002354)1.87592483
148Inability to walk (HP:0002540)1.85753783
149Neurofibrillary tangles (HP:0002185)1.85430290
150Inappropriate behavior (HP:0000719)1.85170453
151Generalized myoclonic seizures (HP:0002123)1.81754773
152Rigidity (HP:0002063)1.80847730
153Abnormality of the corticospinal tract (HP:0002492)1.80039596
154Blue irides (HP:0000635)1.75879535
155Rapidly progressive (HP:0003678)1.75503611
156Apathy (HP:0000741)1.75127079
157Deep palmar crease (HP:0006191)1.74959896
158Incomplete penetrance (HP:0003829)1.74674121
159Limb ataxia (HP:0002070)1.72654739
160Abnormality of salivation (HP:0100755)1.72132483
161Obstructive sleep apnea (HP:0002870)1.71012920
162Abnormality of oral frenula (HP:0000190)1.70465755

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.55574709
2EPHA44.27247143
3MAP3K94.00353611
4MAP4K13.89732609
5RIPK42.82856412
6MAP3K42.80956204
7DAPK22.67296075
8MINK12.59528963
9TXK2.35710735
10KSR22.35099994
11PRKD32.22979457
12PAK62.22401181
13MARK12.17379863
14MAP2K72.13590870
15CAMKK12.13410467
16NTRK21.97323607
17FES1.91373803
18MAP3K121.89089628
19NTRK11.82631804
20SIK21.80173564
21DAPK11.79040602
22ITK1.76679404
23MAP2K41.69917177
24MAP3K131.60583929
25CDK51.57491092
26KSR11.55241741
27CDK191.47334768
28TAOK31.39424653
29TYRO31.37059311
30BTK1.36112011
31CAMKK21.35438198
32MAP3K21.34689745
33STK381.31374582
34JAK11.30483747
35UHMK11.25446976
36PRPF4B1.23587084
37TAOK11.23222069
38PRKCH1.23034277
39TNIK1.20708871
40PLK21.13277342
41ZAP701.12895059
42ARAF1.12496333
43GRK51.11120499
44PRKCG1.11003318
45BLK1.10435431
46HCK1.10138622
47MAPK131.07876063
48PNCK1.04262336
49BMPR21.03638701
50MAPK121.03483741
51TYK21.00728561
52SGK31.00639909
53RET1.00277783
54CAMK10.99989008
55STK110.99870785
56TNK20.98758291
57ALK0.98324060
58SGK4940.97991339
59SGK2230.97991339
60IRAK40.97489012
61SGK20.96660928
62IKBKE0.96502886
63LCK0.96099912
64RAF10.95610349
65CASK0.94031053
66NLK0.93018663
67FGFR40.90710941
68PDK10.90501805
69EPHA30.90478550
70LYN0.90167633
71JAK20.89305106
72MAP3K110.88428581
73FGFR30.86921201
74CSK0.85716076
75JAK30.85219583
76MAP3K10.83096442
77CDK180.82487047
78MARK20.81794687
79CDK150.81042953
80MAP3K70.78373320
81FGFR20.76404556
82CDK140.75193253
83CAMK2A0.73210561
84OXSR10.72948270
85SGK10.72214303
86RIPK10.70646237
87MAP3K140.70349966
88CDK11A0.70138754
89PDPK10.70104117
90SCYL20.67630919
91WNK10.67487246
92CDK120.64639463
93GRK60.64443473
94DYRK1B0.63635674
95CAMK2B0.63351310
96EPHB10.63021181
97PTK2B0.61016317
98DYRK1A0.58021587
99PAK30.57743155
100TEC0.57581475
101CAMK1G0.57057269
102FYN0.55305522
103BRD40.55011749
104MAPK70.54922080
105BRSK10.54859095
106CDC42BPA0.54826717
107MARK30.54107924
108SYK0.54106354
109LMTK20.53813732
110PIM10.53072577
111SIK30.52779824
112WNK30.51515813
113CAMK40.51100362
114RPS6KA30.50014312
115HIPK20.49922557
116PINK10.48648516
117NEK60.46992016
118PASK0.45976647
119CCNB10.45582753
120FGR0.45533749
121MAPK100.44503311
122PHKG10.43109509
123PHKG20.43109509
124CSNK1G20.42410157
125CSF1R0.42070096
126PRKD20.40484749
127DMPK0.40193202
128CDK40.39950907
129ERN10.39797617
130PRKCZ0.37271284
131NEK10.36661759
132PRKCB0.34492198
133MAP2K10.33581766
134RPS6KA20.33307545
135TRIB30.28969875
136PRKCQ0.28230854
137DAPK30.28007871
138MAP3K100.27413893
139CAMK2D0.27072356

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.23348611
2Synaptic vesicle cycle_Homo sapiens_hsa047213.06416993
3Primary immunodeficiency_Homo sapiens_hsa053402.99313470
4Olfactory transduction_Homo sapiens_hsa047402.83279761
5Long-term potentiation_Homo sapiens_hsa047202.78815592
6Circadian entrainment_Homo sapiens_hsa047132.60681908
7Glutamatergic synapse_Homo sapiens_hsa047242.47640911
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.47014951
9GABAergic synapse_Homo sapiens_hsa047272.45399497
10Amphetamine addiction_Homo sapiens_hsa050312.44409593
11Morphine addiction_Homo sapiens_hsa050322.43227827
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.27704105
13Insulin secretion_Homo sapiens_hsa049112.15366625
14Dopaminergic synapse_Homo sapiens_hsa047282.14304356
15Salivary secretion_Homo sapiens_hsa049702.12647517
16Graft-versus-host disease_Homo sapiens_hsa053322.04245059
17Cholinergic synapse_Homo sapiens_hsa047251.95391988
18Gastric acid secretion_Homo sapiens_hsa049711.94082116
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.93734378
20Autoimmune thyroid disease_Homo sapiens_hsa053201.70129720
21Allograft rejection_Homo sapiens_hsa053301.69572613
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.66462489
23Oxytocin signaling pathway_Homo sapiens_hsa049211.64462865
24Renin secretion_Homo sapiens_hsa049241.64239210
25Taste transduction_Homo sapiens_hsa047421.64052914
26Long-term depression_Homo sapiens_hsa047301.63448639
27Cocaine addiction_Homo sapiens_hsa050301.56410037
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.53096022
29Calcium signaling pathway_Homo sapiens_hsa040201.49751173
30Type II diabetes mellitus_Homo sapiens_hsa049301.48078076
31GnRH signaling pathway_Homo sapiens_hsa049121.45244162
32Serotonergic synapse_Homo sapiens_hsa047261.44458479
33Phosphatidylinositol signaling system_Homo sapiens_hsa040701.43203840
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.40244435
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.37739901
36Osteoclast differentiation_Homo sapiens_hsa043801.35704555
37Glioma_Homo sapiens_hsa052141.30007228
38Gap junction_Homo sapiens_hsa045401.25821441
39cAMP signaling pathway_Homo sapiens_hsa040241.25583271
40Leishmaniasis_Homo sapiens_hsa051401.23779798
41Estrogen signaling pathway_Homo sapiens_hsa049151.21647073
42Collecting duct acid secretion_Homo sapiens_hsa049661.19972533
43Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.16280525
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.12498597
45Antigen processing and presentation_Homo sapiens_hsa046121.11828516
46cGMP-PKG signaling pathway_Homo sapiens_hsa040221.11582009
47Intestinal immune network for IgA production_Homo sapiens_hsa046721.08947700
48Acute myeloid leukemia_Homo sapiens_hsa052211.08863512
49Measles_Homo sapiens_hsa051621.05951397
50ErbB signaling pathway_Homo sapiens_hsa040121.04055794
51Pancreatic secretion_Homo sapiens_hsa049721.02954870
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.99312811
53Tuberculosis_Homo sapiens_hsa051520.98553582
54Viral myocarditis_Homo sapiens_hsa054160.97669599
55Carbohydrate digestion and absorption_Homo sapiens_hsa049730.95259537
56Phospholipase D signaling pathway_Homo sapiens_hsa040720.94377967
57Dorso-ventral axis formation_Homo sapiens_hsa043200.91006551
58Neurotrophin signaling pathway_Homo sapiens_hsa047220.89618317
59Melanogenesis_Homo sapiens_hsa049160.89381752
60Vascular smooth muscle contraction_Homo sapiens_hsa042700.87638547
61Oocyte meiosis_Homo sapiens_hsa041140.86837524
62NF-kappa B signaling pathway_Homo sapiens_hsa040640.84887351
63Thyroid hormone synthesis_Homo sapiens_hsa049180.84811202
64VEGF signaling pathway_Homo sapiens_hsa043700.84668182
65Toll-like receptor signaling pathway_Homo sapiens_hsa046200.83292651
66Choline metabolism in cancer_Homo sapiens_hsa052310.82674351
67Type I diabetes mellitus_Homo sapiens_hsa049400.80759360
68MAPK signaling pathway_Homo sapiens_hsa040100.78692395
69Vibrio cholerae infection_Homo sapiens_hsa051100.78654291
70Hepatitis B_Homo sapiens_hsa051610.78152275
71Axon guidance_Homo sapiens_hsa043600.77868936
72Non-small cell lung cancer_Homo sapiens_hsa052230.77227924
73Nitrogen metabolism_Homo sapiens_hsa009100.76236629
74Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.75863314
75mTOR signaling pathway_Homo sapiens_hsa041500.75748954
76Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.75289468
77Jak-STAT signaling pathway_Homo sapiens_hsa046300.74818292
78Inositol phosphate metabolism_Homo sapiens_hsa005620.73600586
79Thyroid hormone signaling pathway_Homo sapiens_hsa049190.72492775
80Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.71793107
81Asthma_Homo sapiens_hsa053100.71066903
82RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.70560526
83Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.70290466
84Pancreatic cancer_Homo sapiens_hsa052120.70130884
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68867272
86Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.66740611
87Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.66118568
88Hematopoietic cell lineage_Homo sapiens_hsa046400.65892947
89Chemokine signaling pathway_Homo sapiens_hsa040620.65390122
90Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.65039888
91Glucagon signaling pathway_Homo sapiens_hsa049220.64285129
92Phototransduction_Homo sapiens_hsa047440.63937008
93Herpes simplex infection_Homo sapiens_hsa051680.63155624
94Chronic myeloid leukemia_Homo sapiens_hsa052200.63013459
95B cell receptor signaling pathway_Homo sapiens_hsa046620.62112950
96Staphylococcus aureus infection_Homo sapiens_hsa051500.61733198
97Cardiac muscle contraction_Homo sapiens_hsa042600.61601664
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.60065806
99FoxO signaling pathway_Homo sapiens_hsa040680.59559219
100Endocytosis_Homo sapiens_hsa041440.58984853
101Influenza A_Homo sapiens_hsa051640.57987692
102Dilated cardiomyopathy_Homo sapiens_hsa054140.57542120
103Toxoplasmosis_Homo sapiens_hsa051450.56599806
104Endometrial cancer_Homo sapiens_hsa052130.56183745
105Alcoholism_Homo sapiens_hsa050340.55708180
106T cell receptor signaling pathway_Homo sapiens_hsa046600.55698394
107Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55008786
108Rap1 signaling pathway_Homo sapiens_hsa040150.54651715
109Hepatitis C_Homo sapiens_hsa051600.54217553
110Regulation of autophagy_Homo sapiens_hsa041400.53665344
111Ras signaling pathway_Homo sapiens_hsa040140.51905287
112Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49628936
113Circadian rhythm_Homo sapiens_hsa047100.49475858
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.48406697
115Renal cell carcinoma_Homo sapiens_hsa052110.47336497
116Platelet activation_Homo sapiens_hsa046110.45918617
117Insulin signaling pathway_Homo sapiens_hsa049100.45641456
118Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45087284
119Prolactin signaling pathway_Homo sapiens_hsa049170.43778891
120African trypanosomiasis_Homo sapiens_hsa051430.37625141
121Colorectal cancer_Homo sapiens_hsa052100.35944388
122Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.35922638
123Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34636858
124Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.33806839
125SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32782980
126Bile secretion_Homo sapiens_hsa049760.30961041
127Wnt signaling pathway_Homo sapiens_hsa043100.30036128
128Prion diseases_Homo sapiens_hsa050200.27415633
129Central carbon metabolism in cancer_Homo sapiens_hsa052300.25561421

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