CYGB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a globin protein found in vertebrate cells. The encoded protein is described as a hexacoordinate hemoglobin which binds ligand differently from the pentacoordinate hemoglobins involved in oxygen transport, and may be involved in protection during oxidative stress. This gene is located on chromosome 17 in the same region as a retinal gene which is mutated in progressive rod-cone degeneration, but in the opposite orientation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell migration involved in heart development (GO:0060973)4.49130248
2protein heterotrimerization (GO:0070208)4.37035115
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.30662949
4vocalization behavior (GO:0071625)4.28657868
5synaptic vesicle maturation (GO:0016188)4.00574362
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.98830993
7cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.88931954
8synaptic vesicle exocytosis (GO:0016079)3.85798455
9regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.72786445
10regulation of synapse structural plasticity (GO:0051823)3.71325636
11positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.68523744
12membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.67810504
13locomotory exploration behavior (GO:0035641)3.67782180
14low-density lipoprotein particle clearance (GO:0034383)3.67472634
15basement membrane organization (GO:0071711)3.63816799
16regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.61598133
17virion attachment to host cell (GO:0019062)3.52310119
18adhesion of symbiont to host cell (GO:0044650)3.52310119
19cell communication by electrical coupling (GO:0010644)3.51722230
20barbed-end actin filament capping (GO:0051016)3.48781239
21regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.48025716
22positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.42201631
23extracellular fibril organization (GO:0043206)3.42194800
24regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.40337932
25neurotransmitter secretion (GO:0007269)3.40170657
26peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.39276605
27adhesion of symbiont to host (GO:0044406)3.38783791
28regulation of glutamate receptor signaling pathway (GO:1900449)3.38380228
29endodermal cell differentiation (GO:0035987)3.36732075
30positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.35151881
31glutamate secretion (GO:0014047)3.33980018
32regulation of synaptic vesicle exocytosis (GO:2000300)3.31783257
33regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.29226826
34activation of protein kinase A activity (GO:0034199)3.29118569
35positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.28731647
36regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.24370961
37regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.23523164
38cardiac myofibril assembly (GO:0055003)3.22773522
39plasma membrane repair (GO:0001778)3.22761487
40regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.21681817
41regulation of membrane repolarization (GO:0060306)3.20923579
42cell communication involved in cardiac conduction (GO:0086065)3.20339530
43negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.17105142
44neuromuscular process controlling posture (GO:0050884)3.16771863
45regulation of synaptic vesicle transport (GO:1902803)3.15915063
46fibril organization (GO:0097435)3.13567289
47negative regulation of potassium ion transmembrane transport (GO:1901380)3.13356284
48proline transport (GO:0015824)3.11734000
49synaptic vesicle docking involved in exocytosis (GO:0016081)3.11292865
50protein localization to synapse (GO:0035418)3.10410510
51regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.10341514
52positive regulation of potassium ion transmembrane transport (GO:1901381)3.07447340
53glomerular filtration (GO:0003094)3.04415781
54negative regulation of cytosolic calcium ion concentration (GO:0051481)3.04389684
55exploration behavior (GO:0035640)3.00686733
56neuronal action potential propagation (GO:0019227)2.98932553
57regulation of extracellular matrix disassembly (GO:0010715)2.98483237
58regulation of cell communication by electrical coupling (GO:0010649)2.97854370
59NADH metabolic process (GO:0006734)2.93645087
60renal filtration (GO:0097205)2.93000916
61sodium ion export (GO:0071436)2.92995658
62cellular potassium ion homeostasis (GO:0030007)2.92552830
63regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.90319874
64neurotransmitter transport (GO:0006836)2.89421526
65positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.88895623
66ethanol oxidation (GO:0006069)2.88414010
67protein carboxylation (GO:0018214)2.88168611
68peptidyl-glutamic acid carboxylation (GO:0017187)2.88168611
69detection of calcium ion (GO:0005513)2.88136112
70positive regulation of lipoprotein lipase activity (GO:0051006)2.87620577
71positive regulation of triglyceride lipase activity (GO:0061365)2.87620577
72chondrocyte proliferation (GO:0035988)2.86913766
73cardiac muscle contraction (GO:0060048)2.86532836
74membrane depolarization during action potential (GO:0086010)2.86423945
75regulation of plasminogen activation (GO:0010755)2.86349819
76triglyceride catabolic process (GO:0019433)2.84789277
77regulation of calcium ion transmembrane transporter activity (GO:1901019)2.84156250
78regulation of calcium ion transmembrane transport (GO:1903169)2.84156250
79regulation of neuronal synaptic plasticity (GO:0048168)2.82091735
80regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.78697835
81ionotropic glutamate receptor signaling pathway (GO:0035235)2.77380458
82collagen fibril organization (GO:0030199)2.76613130
83sarcomere organization (GO:0045214)2.76373304
84melanin biosynthetic process (GO:0042438)2.76159524
85regulation of apoptotic cell clearance (GO:2000425)2.75831703
86potassium ion import (GO:0010107)2.75207944
87neuron cell-cell adhesion (GO:0007158)2.75168368
88vascular endothelial growth factor signaling pathway (GO:0038084)2.74968942
89apoptotic cell clearance (GO:0043277)2.74603579
90extracellular matrix assembly (GO:0085029)2.73843089
91neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.73235380
92lung vasculature development (GO:0060426)2.72923430
93acylglycerol catabolic process (GO:0046464)2.72833131
94neutral lipid catabolic process (GO:0046461)2.72833131
95hemidesmosome assembly (GO:0031581)2.72489665
96regulation of neurotransmitter levels (GO:0001505)2.71178325
97regulation of long-term neuronal synaptic plasticity (GO:0048169)2.70782024
98myofibril assembly (GO:0030239)2.69844598
99neurotransmitter catabolic process (GO:0042135)2.68879837
100cerebellar Purkinje cell differentiation (GO:0021702)2.67827980
101sequestering of extracellular ligand from receptor (GO:0035581)2.67456275
102regulation of actin filament-based movement (GO:1903115)2.65957548
103potassium ion homeostasis (GO:0055075)2.65206324
104positive regulation of potassium ion transport (GO:0043268)2.64207915
105regulation of voltage-gated calcium channel activity (GO:1901385)2.61759373
106regulation of relaxation of muscle (GO:1901077)2.61467021
107cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.61015448
108type B pancreatic cell proliferation (GO:0044342)2.59272155
109layer formation in cerebral cortex (GO:0021819)2.58695130
110neuronal ion channel clustering (GO:0045161)2.58370895
111neuron-neuron synaptic transmission (GO:0007270)2.57221438
112gamma-aminobutyric acid transport (GO:0015812)2.57211699
113regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.57168477
114keratan sulfate catabolic process (GO:0042340)2.57121981
115regulation of cholesterol homeostasis (GO:2000188)2.56710956
116mating behavior (GO:0007617)2.56124046
117neurotransmitter-gated ion channel clustering (GO:0072578)2.55580390
118multicellular organismal macromolecule metabolic process (GO:0044259)2.55502543
119collagen metabolic process (GO:0032963)2.54955761
120neuron recognition (GO:0008038)2.54386968
121complement activation, classical pathway (GO:0006958)2.54293618
122long-term memory (GO:0007616)2.52265901
123cGMP-mediated signaling (GO:0019934)2.51791245
124ventricular cardiac muscle cell action potential (GO:0086005)2.51248610
125protein retention in ER lumen (GO:0006621)2.50561171
126regulation of synaptic transmission, dopaminergic (GO:0032225)2.49982260
127cell-substrate junction assembly (GO:0007044)2.49569768
128synaptic transmission, glutamatergic (GO:0035249)2.49113674
129glycine transport (GO:0015816)2.48636048
130striatum development (GO:0021756)2.48602433
131regulation of heart rate by cardiac conduction (GO:0086091)2.48280486
132sarcoplasmic reticulum calcium ion transport (GO:0070296)2.47711852
133extracellular matrix disassembly (GO:0022617)2.47463335
134multicellular organismal metabolic process (GO:0044236)2.47115837
135cellular sodium ion homeostasis (GO:0006883)2.47002155
136cardiac conduction (GO:0061337)2.46902957
137regulation of excitatory postsynaptic membrane potential (GO:0060079)2.45844445
138positive regulation of sodium ion transport (GO:0010765)2.45221836
139dendritic spine morphogenesis (GO:0060997)2.44689988
140glutamate receptor signaling pathway (GO:0007215)2.44559497
141positive regulation of endothelial cell apoptotic process (GO:2000353)2.44498161
142collagen catabolic process (GO:0030574)2.44212068
143tricarboxylic acid cycle (GO:0006099)2.43623661
144multicellular organismal catabolic process (GO:0044243)2.43559081
145growth hormone secretion (GO:0030252)2.43498350
146melanin metabolic process (GO:0006582)2.43096682
147negative regulation of potassium ion transport (GO:0043267)2.42020779
148negative regulation of smooth muscle cell migration (GO:0014912)2.41636072
149regulation of potassium ion transmembrane transport (GO:1901379)2.41455816
150regulation of vesicle fusion (GO:0031338)2.41218635
151regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.40853164
152positive regulation of pseudopodium assembly (GO:0031274)2.40342508
153synaptic vesicle endocytosis (GO:0048488)2.39981892
154negative regulation of fatty acid transport (GO:2000192)2.39686930
155regulation of postsynaptic membrane potential (GO:0060078)2.39186155
156positive regulation of synaptic transmission, GABAergic (GO:0032230)2.38082756
157diacylglycerol metabolic process (GO:0046339)2.36185318
158negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.36065120
159skin morphogenesis (GO:0043589)2.34710525
160ethanol metabolic process (GO:0006067)2.34709111
161regulation of metalloenzyme activity (GO:0048552)2.34294025
162plasma lipoprotein particle clearance (GO:0034381)2.33966344
163transcytosis (GO:0045056)2.33041825
164positive regulation of extracellular matrix organization (GO:1903055)2.32802290
165maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.31508928
166muscle cell migration (GO:0014812)2.30850693
167angiotensin maturation (GO:0002003)2.29414320
168regulation of pseudopodium assembly (GO:0031272)2.29260553
169negative regulation of chondrocyte differentiation (GO:0032331)2.27892196
170actin filament depolymerization (GO:0030042)2.27767118
171positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.27009312
172chondroitin sulfate catabolic process (GO:0030207)2.26684824
173endocardial cushion development (GO:0003197)2.23726506
174endothelial cell morphogenesis (GO:0001886)2.22362564
175adherens junction assembly (GO:0034333)2.21757013
176COPI coating of Golgi vesicle (GO:0048205)2.20932686
177Golgi transport vesicle coating (GO:0048200)2.20932686
178cellular response to prostaglandin stimulus (GO:0071379)2.20535014
179regulation of cholesterol storage (GO:0010885)2.20498730
180regulation of complement activation (GO:0030449)2.19652254
181cell proliferation involved in metanephros development (GO:0072203)2.19646614
182triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.19003909
183L-serine transport (GO:0015825)2.18954295
184venous blood vessel morphogenesis (GO:0048845)2.17901136
185peptidyl-proline hydroxylation (GO:0019511)2.17642892
186intestinal absorption (GO:0050892)2.17450114
187complement activation (GO:0006956)2.16494082
188secondary metabolite biosynthetic process (GO:0044550)2.16228823
189metanephric mesenchyme development (GO:0072075)2.15832355
190positive regulation of receptor recycling (GO:0001921)2.15616939
191negative regulation of cartilage development (GO:0061037)2.15551976
192stress fiber assembly (GO:0043149)2.15423615
193retina vasculature morphogenesis in camera-type eye (GO:0061299)2.12804148
194regulation of glycogen (starch) synthase activity (GO:2000465)2.12405750
195regulation of protein activation cascade (GO:2000257)2.11859338
196regulation of membrane protein ectodomain proteolysis (GO:0051043)2.10676348
197negative regulation of catenin import into nucleus (GO:0035414)2.08604276
198positive regulation of fatty acid beta-oxidation (GO:0032000)2.07712293
199epithelial cell-cell adhesion (GO:0090136)2.07569985

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.05948234
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.56454630
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.02170661
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.89622074
5GBX2_23144817_ChIP-Seq_PC3_Human2.74510782
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.68421627
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.68421627
8ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.64500318
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.56493175
10SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.51871010
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.45856513
12* CLOCK_20551151_ChIP-Seq_293T_Human2.44875667
13* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.43528890
14* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.43002974
15DROSHA_22980978_ChIP-Seq_HELA_Human2.39951754
16* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.39348633
17* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.37395677
18* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.32752824
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.28429820
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.25237632
21LXR_22292898_ChIP-Seq_THP-1_Human2.21413839
22* EZH2_27294783_Chip-Seq_ESCs_Mouse2.09322699
23* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.06407155
24ELK3_25401928_ChIP-Seq_HUVEC_Human1.97715673
25RNF2_27304074_Chip-Seq_ESCs_Mouse1.92232788
26AR_21572438_ChIP-Seq_LNCaP_Human1.90777970
27RXR_22158963_ChIP-Seq_LIVER_Mouse1.87302148
28IKZF1_21737484_ChIP-ChIP_HCT116_Human1.86724779
29REST_21632747_ChIP-Seq_MESCs_Mouse1.85933019
30RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.81488457
31TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.79338899
32* RARB_27405468_Chip-Seq_BRAIN_Mouse1.78889654
33EP300_21415370_ChIP-Seq_HL-1_Mouse1.77645049
34CDX2_19796622_ChIP-Seq_MESCs_Mouse1.70173041
35MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.67524363
36TRIM28_21343339_ChIP-Seq_HEK293_Human1.64523591
37TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64391922
38* REST_18959480_ChIP-ChIP_MESCs_Mouse1.62164904
39ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.60759383
40* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.60397310
41PPARA_22158963_ChIP-Seq_LIVER_Mouse1.53382191
42CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.51373873
43RACK7_27058665_Chip-Seq_MCF-7_Human1.50213948
44NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.48435587
45SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.48165073
46LXR_22158963_ChIP-Seq_LIVER_Mouse1.47669241
47ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.47192912
48GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.45845724
49ERG_21242973_ChIP-ChIP_JURKAT_Human1.45421487
50UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.44954785
51NR3C1_23031785_ChIP-Seq_PC12_Mouse1.44097806
52EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43644918
53FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.43638640
54CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.41435557
55ZNF263_19887448_ChIP-Seq_K562_Human1.40824004
56SMAD4_21799915_ChIP-Seq_A2780_Human1.39055237
57NFIB_24661679_ChIP-Seq_LUNG_Mouse1.38743100
58ESR1_21235772_ChIP-Seq_MCF-7_Human1.37505997
59PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.33843344
60SMC1_22415368_ChIP-Seq_MEFs_Mouse1.32883385
61CTBP2_25329375_ChIP-Seq_LNCAP_Human1.32079479
62SMC3_22415368_ChIP-Seq_MEFs_Mouse1.31484597
63PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.30644908
64SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.29988091
65PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.29854236
66NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.29040558
67GATA2_21666600_ChIP-Seq_HMVEC_Human1.27850363
68* RING1B_27294783_Chip-Seq_ESCs_Mouse1.26292263
69CTBP1_25329375_ChIP-Seq_LNCAP_Human1.25001752
70TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.21805437
71PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.21561241
72P63_26484246_Chip-Seq_KERATINOCYTES_Human1.21406591
73PIAS1_25552417_ChIP-Seq_VCAP_Human1.19981533
74TAF15_26573619_Chip-Seq_HEK293_Human1.19752600
75* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19284563
76SOX2_21211035_ChIP-Seq_LN229_Gbm1.18599363
77* RAD21_21589869_ChIP-Seq_MESCs_Mouse1.18221005
78NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.18207311
79NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.17230807
80* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.15994455
81NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.15098320
82RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.14943872
83BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.14175999
84SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14112787
85ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.12765397
86KDM2B_26808549_Chip-Seq_K562_Human1.11151750
87ZNF274_21170338_ChIP-Seq_K562_Hela1.10943435
88STAT6_21828071_ChIP-Seq_BEAS2B_Human1.09836593
89P300_27058665_Chip-Seq_ZR-75-30cells_Human1.09479576
90ESR1_20079471_ChIP-ChIP_T-47D_Human1.09356419
91SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.09172103
92HIF1A_21447827_ChIP-Seq_MCF-7_Human1.08931044
93AR_19668381_ChIP-Seq_PC3_Human1.08053479
94TP53_22127205_ChIP-Seq_IMR90_Human1.07918256
95ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07785821
96AHR_22903824_ChIP-Seq_MCF-7_Human1.06478576
97* PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.06428550
98RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.06081851
99* TET1_21490601_ChIP-Seq_MESCs_Mouse1.04454865
100SOX9_24532713_ChIP-Seq_HFSC_Mouse1.03906972
101WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.03854695
102* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.03242165
103TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03188574
104ZFP281_18757296_ChIP-ChIP_E14_Mouse1.02646295
105SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.02543670
106CTCF_27219007_Chip-Seq_Bcells_Human1.02516668
107ESR2_21235772_ChIP-Seq_MCF-7_Human1.02445045
108CJUN_26792858_Chip-Seq_BT549_Human1.02126706
109AR_25329375_ChIP-Seq_VCAP_Human1.01781630
110TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01390228
111THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.01124006
112TET1_21451524_ChIP-Seq_MESCs_Mouse1.00906499
113CDX2_20551321_ChIP-Seq_CACO-2_Human1.00387373
114SMAD4_21741376_ChIP-Seq_HESCs_Human1.00334878
115KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.00265492
116ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.00214710
117SA1_27219007_Chip-Seq_ERYTHROID_Human0.98791598
118TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98489357
119ARNT_22903824_ChIP-Seq_MCF-7_Human0.98286533
120BCAT_22108803_ChIP-Seq_LS180_Human0.98080963
121KDM2B_26808549_Chip-Seq_DND41_Human0.96993618
122KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.96149050
123* SMC4_20622854_ChIP-Seq_HELA_Human0.96145798
124SMAD3_21741376_ChIP-Seq_EPCs_Human0.95891824
125TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.95563772
126P300_19829295_ChIP-Seq_ESCs_Human0.95455784
127KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.95416200
128MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95266554
129SA1_22415368_ChIP-Seq_MEFs_Mouse0.95258804
130TP53_23651856_ChIP-Seq_MEFs_Mouse0.95176424
131STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.95080569
132CTCF_27219007_Chip-Seq_ERYTHROID_Human0.95034103
133SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94797480
134PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.93636044
135RARG_19884340_ChIP-ChIP_MEFs_Mouse0.92258392
136PPAR_26484153_Chip-Seq_NCI-H1993_Human0.92160292
137* FOXA2_19822575_ChIP-Seq_HepG2_Human0.92106547
138* RING1B_27294783_Chip-Seq_NPCs_Mouse0.92041794
139CBX2_27304074_Chip-Seq_ESCs_Mouse0.91794651
140STAT3_23295773_ChIP-Seq_U87_Human0.91039493
141SMAD_19615063_ChIP-ChIP_OVARY_Human0.91019858
142TP63_22573176_ChIP-Seq_HFKS_Human0.90227942
143EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.89877593
144GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89123208
145TP53_16413492_ChIP-PET_HCT116_Human0.87249870
146RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.87237573
147SMAD3_21741376_ChIP-Seq_HESCs_Human0.87208127
148ZFP57_27257070_Chip-Seq_ESCs_Mouse0.87064809
149NR3C1_21868756_ChIP-Seq_MCF10A_Human0.85225770
150BMI1_23680149_ChIP-Seq_NPCS_Mouse0.85180370
151* TBX20_22080862_ChIP-Seq_HEART_Mouse0.85036167
152* TBX20_22328084_ChIP-Seq_HEART_Mouse0.85036167
153ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.84636435
154OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84295020
155UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.83989896
156TP53_20018659_ChIP-ChIP_R1E_Mouse0.83428957
157TP53_18474530_ChIP-ChIP_U2OS_Human0.83126642
158TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82421655
159AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.80154897
160TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.79600397

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.08206789
2MP0002837_dystrophic_cardiac_calcinosis4.02023748
3MP0005257_abnormal_intraocular_pressure3.86574728
4MP0000751_myopathy3.70320020
5MP0002822_catalepsy3.30611612
6MP0003705_abnormal_hypodermis_morpholog3.28136971
7MP0005409_darkened_coat_color2.81326598
8MP0003635_abnormal_synaptic_transmissio2.75691877
9MP0003880_abnormal_central_pattern2.73364346
10MP0008438_abnormal_cutaneous_collagen2.69065297
11MP0003646_muscle_fatigue2.64426674
12MP0004215_abnormal_myocardial_fiber2.52014744
13MP0005503_abnormal_tendon_morphology2.51487131
14MP0005171_absent_coat_pigmentation2.50559483
15MP0004084_abnormal_cardiac_muscle2.40388652
16MP0009046_muscle_twitch2.34131400
17MP0009745_abnormal_behavioral_response2.30704478
18MP0005275_abnormal_skin_tensile2.21519255
19MP0002064_seizures2.18974903
20MP0004036_abnormal_muscle_relaxation2.16447746
21MP0001501_abnormal_sleep_pattern2.14865743
22MP0009840_abnormal_foam_cell2.11137738
23MP0002063_abnormal_learning/memory/cond2.02795113
24MP0002272_abnormal_nervous_system1.96040477
25MP0004270_analgesia1.94292118
26MP0005360_urolithiasis1.86108563
27MP0003566_abnormal_cell_adhesion1.85909211
28MP0006276_abnormal_autonomic_nervous1.84475380
29MP0002572_abnormal_emotion/affect_behav1.83440363
30MP0005330_cardiomyopathy1.82685181
31MP0000749_muscle_degeneration1.74339714
32MP0002909_abnormal_adrenal_gland1.72807283
33MP0004085_abnormal_heartbeat1.71731448
34MP0005058_abnormal_lysosome_morphology1.71633174
35MP0001968_abnormal_touch/_nociception1.66888480
36MP0004858_abnormal_nervous_system1.65393529
37MP0002734_abnormal_mechanical_nocicepti1.63973526
38MP0004145_abnormal_muscle_electrophysio1.62038968
39MP0001440_abnormal_grooming_behavior1.60688757
40MP0003137_abnormal_impulse_conducting1.58510976
41MP0002735_abnormal_chemical_nociception1.57155022
42MP0004130_abnormal_muscle_cell1.56425523
43MP0005620_abnormal_muscle_contractility1.55118787
44MP0006054_spinal_hemorrhage1.53558872
45MP0008775_abnormal_heart_ventricle1.53046992
46MP0004484_altered_response_of1.52932184
47MP0000013_abnormal_adipose_tissue1.52651029
48MP0002972_abnormal_cardiac_muscle1.52232636
49MP0005423_abnormal_somatic_nervous1.51682886
50MP0008569_lethality_at_weaning1.51219826
51MP0001486_abnormal_startle_reflex1.50610870
52MP0010329_abnormal_lipoprotein_level1.50090926
53MP0000767_abnormal_smooth_muscle1.49574364
54MP0002933_joint_inflammation1.48838143
55MP0004924_abnormal_behavior1.48354610
56MP0005386_behavior/neurological_phenoty1.48354610
57MP0002108_abnormal_muscle_morphology1.46069544
58MP0001958_emphysema1.45577066
59MP0005508_abnormal_skeleton_morphology1.44597715
60MP0009780_abnormal_chondrocyte_physiolo1.43231813
61MP0001542_abnormal_bone_strength1.42105946
62MP0003136_yellow_coat_color1.41516304
63MP0002060_abnormal_skin_morphology1.38542090
64MP0002733_abnormal_thermal_nociception1.36914424
65MP0004087_abnormal_muscle_fiber1.35027362
66MP0005666_abnormal_adipose_tissue1.34528623
67MP0006138_congestive_heart_failure1.34006177
68MP0001970_abnormal_pain_threshold1.33845788
69MP0002295_abnormal_pulmonary_circulatio1.33553456
70MP0002067_abnormal_sensory_capabilities1.32870010
71MP0010386_abnormal_urinary_bladder1.32807310
72MP0002896_abnormal_bone_mineralization1.30866017
73MP0001849_ear_inflammation1.28201651
74MP0002971_abnormal_brown_adipose1.27914679
75MP0000747_muscle_weakness1.27753971
76MP0005023_abnormal_wound_healing1.25888442
77MP0002736_abnormal_nociception_after1.22227818
78MP0009384_cardiac_valve_regurgitation1.21582959
79MP0001544_abnormal_cardiovascular_syste1.20372514
80MP0005385_cardiovascular_system_phenoty1.20372514
81MP0003122_maternal_imprinting1.18088810
82MP0005623_abnormal_meninges_morphology1.17957903
83MP0004233_abnormal_muscle_weight1.17803463
84MP0005369_muscle_phenotype1.17559956
85MP0003279_aneurysm1.16841460
86MP0003091_abnormal_cell_migration1.16798807
87MP0000604_amyloidosis1.15276410
88MP0002184_abnormal_innervation1.13535905
89MP0005595_abnormal_vascular_smooth1.11688755
90MP0002106_abnormal_muscle_physiology1.11306502
91MP0002139_abnormal_hepatobiliary_system1.09505053
92MP0005408_hypopigmentation1.09455784
93MP0001879_abnormal_lymphatic_vessel1.08645285
94MP0003329_amyloid_beta_deposits1.07242122
95MP0000759_abnormal_skeletal_muscle1.06689249
96MP0010368_abnormal_lymphatic_system1.06214989
97MP0000015_abnormal_ear_pigmentation1.05636571
98MP0002557_abnormal_social/conspecific_i1.05548672
99MP0005535_abnormal_body_temperature1.03392395
100MP0002877_abnormal_melanocyte_morpholog1.01722910
101MP0003950_abnormal_plasma_membrane1.00412183
102MP0000750_abnormal_muscle_regeneration1.00301210
103MP0001529_abnormal_vocalization0.99916512
104MP0002269_muscular_atrophy0.99301242
105MP0001905_abnormal_dopamine_level0.98870188
106MP0004272_abnormal_basement_membrane0.98101644
107MP0002998_abnormal_bone_remodeling0.97506008
108MP0005365_abnormal_bile_salt0.97413172
109MP0002066_abnormal_motor_capabilities/c0.96951343
110MP0000343_altered_response_to0.96579559
111MP0004811_abnormal_neuron_physiology0.95820729
112MP0003633_abnormal_nervous_system0.95650199
113MP0002089_abnormal_postnatal_growth/wei0.95334827
114MP0000003_abnormal_adipose_tissue0.94683822
115MP0001502_abnormal_circadian_rhythm0.93678393
116MP0004142_abnormal_muscle_tone0.92509778
117MP0005164_abnormal_response_to0.92036526
118MP0005390_skeleton_phenotype0.91441004
119MP0003879_abnormal_hair_cell0.89783577
120MP0000249_abnormal_blood_vessel0.88511383
121MP0008874_decreased_physiological_sensi0.88009048
122MP0005551_abnormal_eye_electrophysiolog0.87853659
123MP0000230_abnormal_systemic_arterial0.87341981
124MP0000372_irregular_coat_pigmentation0.87102009
125MP0002882_abnormal_neuron_morphology0.87058596
126MP0004510_myositis0.86917229
127MP0005646_abnormal_pituitary_gland0.86571130
128MP0000762_abnormal_tongue_morphology0.86344374
129MP0000955_abnormal_spinal_cord0.85909759
130MP0002090_abnormal_vision0.85363093
131MP0000778_abnormal_nervous_system0.84437679
132MP0003191_abnormal_cellular_cholesterol0.83878562
133MP0005165_increased_susceptibility_to0.83785277
134MP0003172_abnormal_lysosome_physiology0.82552912
135MP0000733_abnormal_muscle_development0.81645166
136MP0008260_abnormal_autophagy0.80809728
137MP0005670_abnormal_white_adipose0.80015741
138MP0001299_abnormal_eye_distance/0.79866485
139MP0001533_abnormal_skeleton_physiology0.79725588
140MP0005645_abnormal_hypothalamus_physiol0.79372850
141MP0002876_abnormal_thyroid_physiology0.77877623
142MP0005197_abnormal_uvea_morphology0.76898928
143MP0002638_abnormal_pupillary_reflex0.75306429
144MP0003868_abnormal_feces_composition0.75168082
145MP0000534_abnormal_ureter_morphology0.75020036
146MP0003011_delayed_dark_adaptation0.74315681
147MP0002127_abnormal_cardiovascular_syste0.73790413
148MP0001177_atelectasis0.73790203
149MP0005375_adipose_tissue_phenotype0.73580277
150MP0002332_abnormal_exercise_endurance0.72990671
151MP0010630_abnormal_cardiac_muscle0.72723909
152MP0004019_abnormal_vitamin_homeostasis0.72561918
153MP0003631_nervous_system_phenotype0.72013155
154MP0008961_abnormal_basal_metabolism0.71101647
155MP0002118_abnormal_lipid_homeostasis0.70912009
156MP0001243_abnormal_dermal_layer0.69852378
157MP0000163_abnormal_cartilage_morphology0.68459068
158MP0000371_diluted_coat_color0.66790249
159MP0005167_abnormal_blood-brain_barrier0.65858615
160MP0000678_abnormal_parathyroid_gland0.65713970
161MP0001614_abnormal_blood_vessel0.63267016
162MP0005451_abnormal_body_composition0.63254098
163MP0003075_altered_response_to0.62612950

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)4.64342059
2Sudden death (HP:0001699)4.60973975
3Focal motor seizures (HP:0011153)4.35985122
4Vertebral compression fractures (HP:0002953)3.91661734
5Broad metatarsal (HP:0001783)3.73436567
6Atrial fibrillation (HP:0005110)3.69740933
7Focal seizures (HP:0007359)3.64680263
8Vascular tortuosity (HP:0004948)3.63539891
9Aortic dissection (HP:0002647)3.62320521
10Aortic aneurysm (HP:0004942)3.61933457
11Exercise-induced myalgia (HP:0003738)3.60730472
12Systemic lupus erythematosus (HP:0002725)3.54618856
13Calf muscle hypertrophy (HP:0008981)3.53870335
14Primary atrial arrhythmia (HP:0001692)3.53767184
15Complement deficiency (HP:0004431)3.51157819
16Prolonged QT interval (HP:0001657)3.39597792
17Supraventricular tachycardia (HP:0004755)3.36222762
18Ventricular fibrillation (HP:0001663)3.35986073
19Follicular hyperkeratosis (HP:0007502)3.35797375
20Muscle fiber splitting (HP:0003555)3.33885737
21Supraventricular arrhythmia (HP:0005115)3.33203362
22Atrophic scars (HP:0001075)3.31431259
23Abnormality of the calf musculature (HP:0001430)3.30755915
24Abnormality of complement system (HP:0005339)3.30327097
25Bundle branch block (HP:0011710)3.29248030
26Arterial tortuosity (HP:0005116)3.28979787
27Muscle hypertrophy of the lower extremities (HP:0008968)3.24838565
28Visual hallucinations (HP:0002367)3.15858705
29Myotonia (HP:0002486)3.12534294
30Soft skin (HP:0000977)3.10363830
31Cervical subluxation (HP:0003308)3.06799821
32Increased variability in muscle fiber diameter (HP:0003557)3.06552397
33Syncope (HP:0001279)3.04905913
34Pheochromocytoma (HP:0002666)3.03902732
35Fragile skin (HP:0001030)3.00148078
36Atonic seizures (HP:0010819)3.00004589
37Action tremor (HP:0002345)2.98838085
38Increased connective tissue (HP:0009025)2.97381581
39Ventricular tachycardia (HP:0004756)2.94763792
40Shallow orbits (HP:0000586)2.94383972
41Wormian bones (HP:0002645)2.90171592
42Hyporeflexia of lower limbs (HP:0002600)2.89404119
43Abnormal EKG (HP:0003115)2.78773049
44Slender build (HP:0001533)2.78049970
45Deep venous thrombosis (HP:0002625)2.74938521
46Exercise-induced muscle cramps (HP:0003710)2.73992907
47Blue sclerae (HP:0000592)2.69066008
48Ventricular arrhythmia (HP:0004308)2.68640198
49Round ear (HP:0100830)2.67611132
50Progressive cerebellar ataxia (HP:0002073)2.65369593
51Febrile seizures (HP:0002373)2.65243885
52Dysmetric saccades (HP:0000641)2.61794291
53Lipoatrophy (HP:0100578)2.61512202
54Neuroendocrine neoplasm (HP:0100634)2.60181360
55Right ventricular cardiomyopathy (HP:0011663)2.57771928
56Generalized tonic-clonic seizures (HP:0002069)2.57449311
57Type 1 muscle fiber predominance (HP:0003803)2.56852726
58Peritonitis (HP:0002586)2.54610862
59Difficulty running (HP:0009046)2.50157219
60Absence seizures (HP:0002121)2.49218346
61Abnormality of skeletal muscle fiber size (HP:0012084)2.48388567
62Palpitations (HP:0001962)2.48197228
63Protrusio acetabuli (HP:0003179)2.47358515
64EMG: myopathic abnormalities (HP:0003458)2.44410310
65Anxiety (HP:0000739)2.44319870
66Heart block (HP:0012722)2.41302970
67Torticollis (HP:0000473)2.40740154
68Epileptic encephalopathy (HP:0200134)2.36955350
69Hypoventilation (HP:0002791)2.36650447
70Skin nodule (HP:0200036)2.35471183
71Aneurysm (HP:0002617)2.35123556
72Abnormal atrioventricular conduction (HP:0005150)2.34501880
73Mitral stenosis (HP:0001718)2.33875747
74Xanthomatosis (HP:0000991)2.33346379
75Dilatation of the ascending aorta (HP:0005111)2.32630779
76Joint stiffness (HP:0001387)2.30484230
77Neonatal short-limb short stature (HP:0008921)2.29862367
78Hemorrhage of the eye (HP:0011885)2.29091163
79Central scotoma (HP:0000603)2.28219368
80Depression (HP:0000716)2.27830883
81Glomerulonephritis (HP:0000099)2.23764213
82Abnormality of dentin (HP:0010299)2.22936439
83Atrioventricular block (HP:0001678)2.20944240
84Myoglobinuria (HP:0002913)2.20503144
85Hyperextensible skin (HP:0000974)2.19774874
86Biconcave vertebral bodies (HP:0004586)2.19074337
87Dysdiadochokinesis (HP:0002075)2.18548233
88Thin bony cortex (HP:0002753)2.17632913
89Supranuclear gaze palsy (HP:0000605)2.16803350
90Mildly elevated creatine phosphokinase (HP:0008180)2.16059067
91Bradycardia (HP:0001662)2.16049170
92Upper limb amyotrophy (HP:0009129)2.14078628
93Distal upper limb amyotrophy (HP:0007149)2.14078628
94Ankle clonus (HP:0011448)2.13605860
95Genu recurvatum (HP:0002816)2.10984048
96Bladder diverticulum (HP:0000015)2.10649524
97Neurofibrillary tangles (HP:0002185)2.09390314
98Dialeptic seizures (HP:0011146)2.09346300
99Long toe (HP:0010511)2.09190715
100Postural instability (HP:0002172)2.08289677
101Joint laxity (HP:0001388)2.06426474
102Cardiovascular calcification (HP:0011915)2.06303806
103Cerebral aneurysm (HP:0004944)2.05803805
104Impaired social interactions (HP:0000735)2.03335321
105Abnormal social behavior (HP:0012433)2.03335321
106Achilles tendon contracture (HP:0001771)2.02642803
107Distal lower limb muscle weakness (HP:0009053)2.02019251
108Hypercortisolism (HP:0001578)2.01408637
109Asymmetric septal hypertrophy (HP:0001670)2.01320989
110Focal dystonia (HP:0004373)2.01158688
111Coxa vara (HP:0002812)2.00733661
112Left ventricular hypertrophy (HP:0001712)2.00654647
113Abnormality of the left ventricular outflow tract (HP:0011103)2.00182874
114Subaortic stenosis (HP:0001682)2.00182874
115Limb dystonia (HP:0002451)1.99178290
116Wrist flexion contracture (HP:0001239)1.98802325
117Acanthosis nigricans (HP:0000956)1.98468770
118Craniofacial dystonia (HP:0012179)1.97607394
119Elbow flexion contracture (HP:0002987)1.97467732
120Mitral valve prolapse (HP:0001634)1.97321784
121Premature rupture of membranes (HP:0001788)1.97252729
122Abnormality of the Achilles tendon (HP:0005109)1.96658745
123Abnormal eating behavior (HP:0100738)1.94574979
124Poor eye contact (HP:0000817)1.93170446
125Pulmonary artery stenosis (HP:0004415)1.92897643
126Dysostosis multiplex (HP:0000943)1.92730080
127Abnormality of glutamine family amino acid metabolism (HP:0010902)1.92656077
128Abnormality of proline metabolism (HP:0010907)1.91571186
129Hydroxyprolinuria (HP:0003080)1.91571186
130Nephritis (HP:0000123)1.90095730
131Rapidly progressive (HP:0003678)1.89947695
132Lower limb amyotrophy (HP:0007210)1.89933421
133Amblyopia (HP:0000646)1.89726354
134White forelock (HP:0002211)1.89508154
135Stridor (HP:0010307)1.89141468
136Abnormality of the acetabulum (HP:0003170)1.88564115
137Muscle stiffness (HP:0003552)1.88238345
138Urinary glycosaminoglycan excretion (HP:0003541)1.87801790
139Mucopolysacchariduria (HP:0008155)1.87801790
140Obstructive sleep apnea (HP:0002870)1.87782687
141Striae distensae (HP:0001065)1.87106020
142Hypoplasia of the iris (HP:0007676)1.86984570
143Axonal loss (HP:0003447)1.86648317
144Hemiplegia (HP:0002301)1.86608204
145Dilated cardiomyopathy (HP:0001644)1.86435884
146Broad-based gait (HP:0002136)1.85686775
147Foot dorsiflexor weakness (HP:0009027)1.85498096
148Narrow nasal bridge (HP:0000446)1.84767377
149Abnormal delivery (HP:0001787)1.83861832
150Ankle contracture (HP:0006466)1.83319534
151Difficulty climbing stairs (HP:0003551)1.83131611
152Dysmetria (HP:0001310)1.82636801
153Neoplasm of the peripheral nervous system (HP:0100007)1.82573645
154Lymphangioma (HP:0100764)1.81478513
155Spondylolisthesis (HP:0003302)1.81239098
156Polycythemia (HP:0001901)1.81205446
157Distal lower limb amyotrophy (HP:0008944)1.80051334
158Venous abnormality (HP:0002624)1.79963379
159Cerebral inclusion bodies (HP:0100314)1.79958310
160Bronchomalacia (HP:0002780)1.79552228
161Abnormality of polysaccharide metabolism (HP:0011012)1.78825777
162Abnormality of glycosaminoglycan metabolism (HP:0004371)1.78825777
163Abnormality of mucopolysaccharide metabolism (HP:0011020)1.78825777
164Generalized amyotrophy (HP:0003700)1.78765643
165Ovoid vertebral bodies (HP:0003300)1.78699958
166Abnormality of the foot musculature (HP:0001436)1.78331569
167Hypertriglyceridemia (HP:0002155)1.78223492
168Spinal rigidity (HP:0003306)1.78091492
169Ectopia lentis (HP:0001083)1.77990381
170Bowel diverticulosis (HP:0005222)1.77822541
171Gaze-evoked nystagmus (HP:0000640)1.77181348
172Scotoma (HP:0000575)1.76602243
173Hypothermia (HP:0002045)1.76064961
174Oligomenorrhea (HP:0000876)1.74756127
175Emphysema (HP:0002097)1.74581207
176Ulnar deviation of the wrist (HP:0003049)1.73480032
177Abnormality of the lower motor neuron (HP:0002366)1.72641388
178Aortic regurgitation (HP:0001659)1.72598641
179Abnormal mitochondria in muscle tissue (HP:0008316)1.72192181
180Annular pancreas (HP:0001734)1.72070711
181Flared iliac wings (HP:0002869)1.72048334
182Myocardial infarction (HP:0001658)1.71321006
183Vascular calcification (HP:0004934)1.70921155
184Joint hemorrhage (HP:0005261)1.70580119
185Osteolytic defects of the hand bones (HP:0009699)1.69517923

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.67900902
2ERN13.33819383
3MAP3K42.92704647
4TGFBR22.79836128
5LMTK22.71971508
6TESK12.51300735
7PHKG22.49278394
8PHKG12.49278394
9EPHA42.45006500
10TTN2.39224060
11MYLK2.36638885
12MAP3K92.26931481
13FGFR42.18310596
14MINK12.06714957
15MAP2K71.99735523
16PINK11.92672120
17PAK61.86854342
18MAP2K41.81433088
19NTRK11.78306664
20SIK11.75527045
21PTK21.67287615
22MARK11.65136670
23MAP3K121.59259598
24DAPK21.55888256
25GRK51.55062920
26KSR21.53352017
27STK381.50827846
28MAP3K61.43054226
29EPHB11.42838291
30DMPK1.42603060
31PRKD31.41695762
32NTRK21.41575813
33LIMK11.40239493
34PAK31.37728873
35KIT1.37648186
36ICK1.36939088
37LATS21.35362845
38PDK31.32048566
39PDK41.32048566
40CAMKK11.29659988
41ABL21.26395600
42PRKG21.26160689
43PDGFRA1.25126696
44MET1.17546218
45PAK21.17346331
46PAK41.15768904
47PRKCH1.15119282
48TRIB31.14818512
49CAMK2A1.13332164
50WNK11.11513278
51CDK51.09137767
52GRK71.09094681
53PDGFRB1.06566204
54FER1.04880008
55PNCK1.04600306
56MAP3K31.03687476
57PRKD21.02518655
58RIPK11.01117724
59MUSK1.00997798
60ARAF0.99114903
61CAMK10.98086415
62PTK2B0.97911971
63UHMK10.95297525
64DDR20.93834729
65CAMK2D0.93703085
66CDC42BPA0.93496757
67EPHA30.92257194
68OBSCN0.92093716
69FLT30.91554885
70MAPK70.91271006
71PLK20.91101745
72NEK10.90657327
73CAMK1G0.89826871
74TIE10.89701401
75PRKCG0.89232125
76DYRK1B0.86003517
77MAPKAPK30.85699227
78MAP3K110.85388095
79PIM20.85110586
80TAOK10.84736055
81SGK2230.83921971
82SGK4940.83921971
83WNK40.81455192
84PRKCE0.80497251
85MAPK130.80320697
86CAMK2G0.80154313
87FGFR30.79961545
88MAP3K70.79808451
89RET0.77797256
90MST1R0.77444901
91PRPF4B0.77027776
92PRKAA20.76958414
93ROCK10.76808220
94EPHA20.75567175
95MAPK40.75114336
96MOS0.74893840
97ZAP700.74831984
98CAMKK20.74713776
99PRKD10.74228835
100PTK60.74121710
101NEK90.74065176
102PIK3CA0.73488081
103TBK10.73459580
104SGK30.72883370
105CAMK40.72427250
106TRPM70.71137503
107PDK20.71119250
108KSR10.69800379
109STK110.69670558
110SGK20.69347912
111FES0.68047534
112MAP2K10.67991181
113EEF2K0.67568315
114MAP3K20.67099405
115CASK0.65536977
116DAPK30.64575662
117ROCK20.64208053
118NME10.63543322
119TNK20.63196681
120JAK10.61723621
121SIK20.61183364
122MAP3K10.61079920
123INSRR0.60757770
124SMG10.60261646
125GSK3A0.58256003
126TYRO30.56531074
127CAMK2B0.55756649
128GRK60.54687637
129PKN10.54580365
130PIK3CG0.53570979
131PDPK10.53426387
132MAP3K130.52746970
133DAPK10.52402632
134STK390.52090419
135EPHB20.51530375
136SGK10.50970457
137MAPK120.50691375
138ADRBK10.49917587
139RPS6KA20.49616379
140MTOR0.49530928
141ILK0.48873787
142PRKACA0.48603331
143PKN20.48452218
144RPS6KC10.47576955
145RPS6KL10.47576955
146SRC0.46403877
147MARK20.46310098
148BCKDK0.46199409
149TAOK20.45598344
150MAP2K20.42019624
151MAP2K30.40875579
152MAP2K60.39996760
153LATS10.39041009

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.53423629
2Nicotine addiction_Homo sapiens_hsa050332.48778527
3Complement and coagulation cascades_Homo sapiens_hsa046102.43909231
4Cyanoamino acid metabolism_Homo sapiens_hsa004602.32641829
5Cardiac muscle contraction_Homo sapiens_hsa042602.22375125
6GABAergic synapse_Homo sapiens_hsa047272.15397111
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.12219841
8Circadian entrainment_Homo sapiens_hsa047132.08110757
9Olfactory transduction_Homo sapiens_hsa047401.99265264
10Dilated cardiomyopathy_Homo sapiens_hsa054141.97374036
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.96943096
12Glycosaminoglycan degradation_Homo sapiens_hsa005311.95225082
13Fat digestion and absorption_Homo sapiens_hsa049751.88221347
14Morphine addiction_Homo sapiens_hsa050321.86142872
15Amphetamine addiction_Homo sapiens_hsa050311.81797523
16Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.76460539
17Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.74726300
18Other glycan degradation_Homo sapiens_hsa005111.73365134
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.73222781
20Histidine metabolism_Homo sapiens_hsa003401.70485043
21Glutamatergic synapse_Homo sapiens_hsa047241.69238198
22Salivary secretion_Homo sapiens_hsa049701.61716084
23Renin secretion_Homo sapiens_hsa049241.61670441
24Dopaminergic synapse_Homo sapiens_hsa047281.61333264
25Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.59494428
26Long-term potentiation_Homo sapiens_hsa047201.58925011
27Insulin secretion_Homo sapiens_hsa049111.57116847
28Cholinergic synapse_Homo sapiens_hsa047251.56977437
29Gastric acid secretion_Homo sapiens_hsa049711.55532257
30Aldosterone synthesis and secretion_Homo sapiens_hsa049251.55301091
31Cocaine addiction_Homo sapiens_hsa050301.53248953
32Taste transduction_Homo sapiens_hsa047421.51193141
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.49836576
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.49458821
35Oxidative phosphorylation_Homo sapiens_hsa001901.48291648
36Parkinsons disease_Homo sapiens_hsa050121.44608679
37Calcium signaling pathway_Homo sapiens_hsa040201.43856147
38Oxytocin signaling pathway_Homo sapiens_hsa049211.38517564
39Serotonergic synapse_Homo sapiens_hsa047261.36299941
40Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.34320095
41Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.26694014
42Alzheimers disease_Homo sapiens_hsa050101.22880030
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.18455576
44Collecting duct acid secretion_Homo sapiens_hsa049661.18432884
45cAMP signaling pathway_Homo sapiens_hsa040241.16087082
46GnRH signaling pathway_Homo sapiens_hsa049121.15746124
47cGMP-PKG signaling pathway_Homo sapiens_hsa040221.11817165
48Gap junction_Homo sapiens_hsa045401.10494604
49Renin-angiotensin system_Homo sapiens_hsa046141.10068823
50Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.09984976
51Long-term depression_Homo sapiens_hsa047301.09175154
52Vascular smooth muscle contraction_Homo sapiens_hsa042701.07649570
53Glycerolipid metabolism_Homo sapiens_hsa005611.07245288
54Type II diabetes mellitus_Homo sapiens_hsa049301.06187117
55Fructose and mannose metabolism_Homo sapiens_hsa000511.02106943
56AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.01777508
57Propanoate metabolism_Homo sapiens_hsa006400.99764707
58Arginine and proline metabolism_Homo sapiens_hsa003300.98782935
59Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.98225637
60Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.97992645
61Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.93284112
62Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.93090380
63Pertussis_Homo sapiens_hsa051330.91414479
64Sulfur metabolism_Homo sapiens_hsa009200.90763326
65Butanoate metabolism_Homo sapiens_hsa006500.90702845
66Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.90371688
67Galactose metabolism_Homo sapiens_hsa000520.90286325
68Estrogen signaling pathway_Homo sapiens_hsa049150.90197231
69Lysosome_Homo sapiens_hsa041420.89385213
70Mineral absorption_Homo sapiens_hsa049780.89063822
71Nitrogen metabolism_Homo sapiens_hsa009100.85846930
72Phototransduction_Homo sapiens_hsa047440.85113623
73AMPK signaling pathway_Homo sapiens_hsa041520.83120274
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.82440425
75Vitamin digestion and absorption_Homo sapiens_hsa049770.81058654
76Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.80943710
77Staphylococcus aureus infection_Homo sapiens_hsa051500.80184022
78Proteoglycans in cancer_Homo sapiens_hsa052050.79849103
79Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.77450512
80Vibrio cholerae infection_Homo sapiens_hsa051100.76061873
81Phenylalanine metabolism_Homo sapiens_hsa003600.75818955
82Dorso-ventral axis formation_Homo sapiens_hsa043200.75662045
83Glucagon signaling pathway_Homo sapiens_hsa049220.73942155
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.73791854
85Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73183554
86Huntingtons disease_Homo sapiens_hsa050160.71363716
87Melanogenesis_Homo sapiens_hsa049160.70601468
88Chemical carcinogenesis_Homo sapiens_hsa052040.69920836
89Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.69703293
90Axon guidance_Homo sapiens_hsa043600.69436399
91Arginine biosynthesis_Homo sapiens_hsa002200.68880742
92Pyruvate metabolism_Homo sapiens_hsa006200.68013303
93Fatty acid metabolism_Homo sapiens_hsa012120.65230818
94Bile secretion_Homo sapiens_hsa049760.64498255
95Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.63993391
96Starch and sucrose metabolism_Homo sapiens_hsa005000.63729649
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.63632214
98Pancreatic secretion_Homo sapiens_hsa049720.63392225
99ECM-receptor interaction_Homo sapiens_hsa045120.63233485
100Glioma_Homo sapiens_hsa052140.62752796
101Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62498257
102Regulation of actin cytoskeleton_Homo sapiens_hsa048100.62400185
103Thyroid hormone synthesis_Homo sapiens_hsa049180.62304376
104PI3K-Akt signaling pathway_Homo sapiens_hsa041510.62206268
105Insulin signaling pathway_Homo sapiens_hsa049100.61907887
106Tryptophan metabolism_Homo sapiens_hsa003800.61766627
107Sulfur relay system_Homo sapiens_hsa041220.61590424
108Ovarian steroidogenesis_Homo sapiens_hsa049130.60810855
109Malaria_Homo sapiens_hsa051440.59758705
110Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.57727453
111Adipocytokine signaling pathway_Homo sapiens_hsa049200.56972700
112Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.55152830
113Retinol metabolism_Homo sapiens_hsa008300.54938350
114Fatty acid degradation_Homo sapiens_hsa000710.54115434
115Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.53400350
116Focal adhesion_Homo sapiens_hsa045100.53178484
117Carbon metabolism_Homo sapiens_hsa012000.52517386
118MAPK signaling pathway_Homo sapiens_hsa040100.51718114
119ErbB signaling pathway_Homo sapiens_hsa040120.50597018
120Protein digestion and absorption_Homo sapiens_hsa049740.50087893
121PPAR signaling pathway_Homo sapiens_hsa033200.49876505
122Fatty acid biosynthesis_Homo sapiens_hsa000610.49048935
123Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48745838
124Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.46676636
125ABC transporters_Homo sapiens_hsa020100.46401656
126Notch signaling pathway_Homo sapiens_hsa043300.46307351
127Small cell lung cancer_Homo sapiens_hsa052220.46161517
128Central carbon metabolism in cancer_Homo sapiens_hsa052300.46081918
129Leukocyte transendothelial migration_Homo sapiens_hsa046700.45292159
130Prion diseases_Homo sapiens_hsa050200.45151762
131Tyrosine metabolism_Homo sapiens_hsa003500.44878654
132Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44261024
133Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44082378
134beta-Alanine metabolism_Homo sapiens_hsa004100.43744869
135Glutathione metabolism_Homo sapiens_hsa004800.43681335
136Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42981465
137Amoebiasis_Homo sapiens_hsa051460.42832232
138Arachidonic acid metabolism_Homo sapiens_hsa005900.42689404
139Circadian rhythm_Homo sapiens_hsa047100.42564940
140Ras signaling pathway_Homo sapiens_hsa040140.41781778
141Endocytosis_Homo sapiens_hsa041440.41603502
142Insulin resistance_Homo sapiens_hsa049310.41241736
143Glycerophospholipid metabolism_Homo sapiens_hsa005640.40290077
144Tight junction_Homo sapiens_hsa045300.40279189
145Choline metabolism in cancer_Homo sapiens_hsa052310.38414535
146Rap1 signaling pathway_Homo sapiens_hsa040150.38309985
147Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.34884303

Most similar genes based on co-expression Upload to Enrichr

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