CYHR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mannose metabolic process (GO:0006013)5.08908654
2negative regulation of erythrocyte differentiation (GO:0045647)4.99863324
3positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.66080381
4negative regulation of cell killing (GO:0031342)3.64852798
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.64852798
6apoptotic process involved in morphogenesis (GO:0060561)3.46704174
7positive thymic T cell selection (GO:0045059)3.43925068
8antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.41816570
9cell-cell junction maintenance (GO:0045217)3.37622840
10antigen processing and presentation of endogenous antigen (GO:0019883)3.36549081
11signal complex assembly (GO:0007172)3.31025948
12positive regulation of histone deacetylation (GO:0031065)3.28103828
13histone H4 deacetylation (GO:0070933)3.26438309
14synaptic vesicle maturation (GO:0016188)3.26056817
15regulation of ARF protein signal transduction (GO:0032012)3.22136115
16locomotory exploration behavior (GO:0035641)3.21262052
17cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.20082721
18antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.14862439
19sodium ion export (GO:0071436)3.13068010
20regulation of short-term neuronal synaptic plasticity (GO:0048172)3.11292863
21antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.10828240
22detection of bacterium (GO:0016045)3.10783103
23semaphorin-plexin signaling pathway (GO:0071526)3.08355394
24positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.07017338
25thymic T cell selection (GO:0045061)3.06203312
26activation of Rac GTPase activity (GO:0032863)3.04762970
27modulation by virus of host process (GO:0019054)3.03366920
28negative regulation of potassium ion transmembrane transport (GO:1901380)2.98175794
29aspartate family amino acid catabolic process (GO:0009068)2.95991347
30cell communication by electrical coupling (GO:0010644)2.94817583
31detection of other organism (GO:0098543)2.94398249
32NIK/NF-kappaB signaling (GO:0038061)2.94227106
33carnitine shuttle (GO:0006853)2.93717716
34positive regulation of Cdc42 GTPase activity (GO:0043089)2.91730223
35negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.91666820
36response to peptidoglycan (GO:0032494)2.91210544
37sulfur amino acid catabolic process (GO:0000098)2.91092908
38negative regulation of myotube differentiation (GO:0010832)2.90535040
39negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.90294034
40positive regulation by organism of defense response of other organism involved in symbiotic interact2.88433583
41modulation by symbiont of host immune response (GO:0052553)2.88433583
42positive regulation by symbiont of host defense response (GO:0052509)2.88433583
43modulation by symbiont of host defense response (GO:0052031)2.88433583
44modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.88433583
45modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.88433583
46peptidyl-tyrosine autophosphorylation (GO:0038083)2.85555252
47lysine catabolic process (GO:0006554)2.85487630
48lysine metabolic process (GO:0006553)2.85487630
49layer formation in cerebral cortex (GO:0021819)2.83351322
50activation of protein kinase A activity (GO:0034199)2.81162163
51mitochondrion transport along microtubule (GO:0047497)2.80773345
52establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.80773345
53response to muramyl dipeptide (GO:0032495)2.80104009
54alpha-linolenic acid metabolic process (GO:0036109)2.79700049
55modulation by symbiont of host cellular process (GO:0044068)2.79492081
56cellular response to virus (GO:0098586)2.79211138
57cellular potassium ion homeostasis (GO:0030007)2.78768546
58negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.78666792
59positive regulation of protein deacetylation (GO:0090312)2.77172370
60intracellular estrogen receptor signaling pathway (GO:0030520)2.75282679
61positive regulation of gamma-delta T cell activation (GO:0046645)2.73876162
62fatty acid transmembrane transport (GO:1902001)2.73520676
63protein localization to endosome (GO:0036010)2.73495229
64GDP-mannose metabolic process (GO:0019673)2.73122926
65activation of JUN kinase activity (GO:0007257)2.71682073
66negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.71649209
67positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.71295839
68erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.69773733
69L-phenylalanine metabolic process (GO:0006558)2.69773733
70epithelial cell differentiation involved in prostate gland development (GO:0060742)2.67048878
71regulation of leukocyte degranulation (GO:0043300)2.66307539
72barbed-end actin filament capping (GO:0051016)2.66112240
73synaptic vesicle docking involved in exocytosis (GO:0016081)2.66036165
74positive regulation of protein dephosphorylation (GO:0035307)2.64267190
75plasma membrane repair (GO:0001778)2.63330515
762-oxoglutarate metabolic process (GO:0006103)2.62562265
77retrograde transport, endosome to Golgi (GO:0042147)2.62541742
78regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.61438040
79regulation of myeloid leukocyte mediated immunity (GO:0002886)2.61172026
80histone H3 deacetylation (GO:0070932)2.61062619
81erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.59413329
82L-phenylalanine catabolic process (GO:0006559)2.59413329
83regulation of mammary gland epithelial cell proliferation (GO:0033599)2.57953106
84proline biosynthetic process (GO:0006561)2.57378923
85potassium ion import (GO:0010107)2.56470706
86glutamate secretion (GO:0014047)2.55741691
87cell communication involved in cardiac conduction (GO:0086065)2.55440904
88regulation of cholesterol homeostasis (GO:2000188)2.55399276
89synaptic vesicle exocytosis (GO:0016079)2.55381393
90adherens junction assembly (GO:0034333)2.55019731
91cell-substrate adherens junction assembly (GO:0007045)2.53821182
92focal adhesion assembly (GO:0048041)2.53821182
93endothelial cell chemotaxis (GO:0035767)2.53563158
94acetyl-CoA metabolic process (GO:0006084)2.53355790
95cytoskeletal anchoring at plasma membrane (GO:0007016)2.53350024
96regulation of fatty acid beta-oxidation (GO:0031998)2.52113958
97regulation of mast cell degranulation (GO:0043304)2.51669480
98macrophage activation involved in immune response (GO:0002281)2.51521437
99activation of MAPKKK activity (GO:0000185)2.50469135
100regulation of necrotic cell death (GO:0010939)2.49899578
101vocalization behavior (GO:0071625)2.49597176
102dicarboxylic acid catabolic process (GO:0043649)2.49325577
103gamma-aminobutyric acid transport (GO:0015812)2.48178622
104tricarboxylic acid cycle (GO:0006099)2.48141925
105planar cell polarity pathway involved in neural tube closure (GO:0090179)2.47995460
106positive regulation of receptor recycling (GO:0001921)2.47669317
107neuromuscular process controlling posture (GO:0050884)2.47429847
108negative regulation of granulocyte differentiation (GO:0030853)2.47250772
109glutamate metabolic process (GO:0006536)2.46733289
110cellular ketone body metabolic process (GO:0046950)2.45423237
111cell junction maintenance (GO:0034331)2.44824481
112regulation of synaptic vesicle exocytosis (GO:2000300)2.44324311
113regulation of T-helper 2 cell differentiation (GO:0045628)2.42740845
114negative regulation of viral release from host cell (GO:1902187)2.42613956
115positive regulation of myotube differentiation (GO:0010831)2.42548154
116amino-acid betaine transport (GO:0015838)2.42358939
117carnitine transport (GO:0015879)2.42358939
118regulation of regulated secretory pathway (GO:1903305)2.42053507
119regulation of necroptotic process (GO:0060544)2.41624953
120regulation of fatty acid oxidation (GO:0046320)2.41587106
121dicarboxylic acid biosynthetic process (GO:0043650)2.41454628
122positive regulation of CREB transcription factor activity (GO:0032793)2.40858196
123regulation of defense response to virus by virus (GO:0050690)2.40581007
124regulation of hydrogen peroxide metabolic process (GO:0010310)2.40394754
125positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.40358827
126positive regulation of fatty acid beta-oxidation (GO:0032000)2.39722224
127neurotransmitter secretion (GO:0007269)2.39427129
128fatty acid beta-oxidation (GO:0006635)2.39266690
129neuromuscular process controlling balance (GO:0050885)2.38627254
130short-chain fatty acid metabolic process (GO:0046459)2.38235063
131cerebellar Purkinje cell layer development (GO:0021680)2.37590963
132carnitine transmembrane transport (GO:1902603)2.37258203
133apoptotic process involved in development (GO:1902742)2.37175651
134establishment of mitochondrion localization (GO:0051654)2.36715204
135actin filament polymerization (GO:0030041)2.36030779
136regulation of synapse structural plasticity (GO:0051823)2.35382810
137G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.34770484
138maternal placenta development (GO:0001893)2.34152586
139regulation of interferon-beta biosynthetic process (GO:0045357)2.33051335
140negative regulation of cell size (GO:0045792)2.32977198
141regulation of extracellular matrix disassembly (GO:0010715)2.32647997
142membrane tubulation (GO:0097320)2.32545014
143UV protection (GO:0009650)2.32410779
144cellular sodium ion homeostasis (GO:0006883)2.32311911
145detection of external biotic stimulus (GO:0098581)2.32172798
146glyoxylate metabolic process (GO:0046487)2.31559412
147negative regulation of toll-like receptor signaling pathway (GO:0034122)2.31152297
148positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.31021834
149viral protein processing (GO:0019082)2.30337463
150adenosine receptor signaling pathway (GO:0001973)2.30272954
151protein kinase C signaling (GO:0070528)2.29859961
152membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.29774388
153positive regulation of Rap GTPase activity (GO:0032854)2.28413102
154proline metabolic process (GO:0006560)2.28377461
155regulation of type I interferon-mediated signaling pathway (GO:0060338)2.28322725
156negative regulation of innate immune response (GO:0045824)2.28187698
157regulation of synaptic vesicle transport (GO:1902803)2.27915354
158regulation of ARF GTPase activity (GO:0032312)2.27424791
159positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.26826808
160succinate metabolic process (GO:0006105)2.26168410
161exploration behavior (GO:0035640)2.24772041
162cellular modified amino acid catabolic process (GO:0042219)2.24018150
163membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.23517383
164positive regulation of fatty acid oxidation (GO:0046321)2.23423083
165positive regulation of triglyceride biosynthetic process (GO:0010867)2.22834002
166regulation of neuronal synaptic plasticity (GO:0048168)2.22442933
167glycogen catabolic process (GO:0005980)2.22220074
168alanine transport (GO:0032328)2.21107746
169negative regulation of nucleotide catabolic process (GO:0030812)2.20660154
170membrane repolarization (GO:0086009)2.19467914
171regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.19179096
172positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.19068529
173fatty acid catabolic process (GO:0009062)2.18788865
174protein retention in ER lumen (GO:0006621)2.18470130
175regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.17096412
176cardiac muscle contraction (GO:0060048)2.16680023
177cysteine metabolic process (GO:0006534)2.16673687
178neurotransmitter-gated ion channel clustering (GO:0072578)2.16428452
1794-hydroxyproline metabolic process (GO:0019471)2.16000417
180glycine transport (GO:0015816)2.15638458
181glutamine family amino acid biosynthetic process (GO:0009084)2.14341806
182ketone body metabolic process (GO:1902224)2.13876676
183positive regulation of glycogen biosynthetic process (GO:0045725)2.13632107
184stress fiber assembly (GO:0043149)2.13280106
185cell migration in hindbrain (GO:0021535)2.12975367
186regulation of glutamate receptor signaling pathway (GO:1900449)2.12469094
187macroautophagy (GO:0016236)2.12292892
188neuronal action potential propagation (GO:0019227)2.12114010
189tricarboxylic acid metabolic process (GO:0072350)2.10659923
190creatine metabolic process (GO:0006600)2.10291303
191glucan catabolic process (GO:0009251)2.10092943

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_21846776_ChIP-Seq_THP-1_Human3.07243632
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.80155963
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.66896686
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.48988685
5EZH2_22144423_ChIP-Seq_EOC_Human2.48302934
6RXR_22158963_ChIP-Seq_LIVER_Mouse2.38911001
7ELK3_25401928_ChIP-Seq_HUVEC_Human2.38623371
8MYC_22102868_ChIP-Seq_BL_Human2.31286932
9* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.26900502
10* TCF7_22412390_ChIP-Seq_EML_Mouse2.14875325
11ERG_21242973_ChIP-ChIP_JURKAT_Human2.14461968
12* LXR_22292898_ChIP-Seq_THP-1_Human2.10308235
13ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.05108875
14TP63_17297297_ChIP-ChIP_HaCaT_Human2.03342064
15PPARA_22158963_ChIP-Seq_LIVER_Mouse2.01512858
16RARB_27405468_Chip-Seq_BRAIN_Mouse1.98384302
17LXR_22158963_ChIP-Seq_LIVER_Mouse1.96710142
18FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.92149069
19NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.89095591
20DROSHA_22980978_ChIP-Seq_HELA_Human1.87484501
21MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.85882233
22* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.82656560
23VDR_24763502_ChIP-Seq_THP-1_Human1.75121754
24MTF2_20144788_ChIP-Seq_MESCs_Mouse1.72498605
25* ELF1_20517297_ChIP-Seq_JURKAT_Human1.72104772
26NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.70860273
27SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.69941805
28CTCF_27219007_Chip-Seq_ERYTHROID_Human1.69315136
29TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.68738057
30KDM2B_26808549_Chip-Seq_K562_Human1.68623869
31SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.67517915
32BCL6_27268052_Chip-Seq_Bcells_Human1.66360970
33DNAJC2_21179169_ChIP-ChIP_NT2_Human1.64911694
34E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.64753095
35BCOR_27268052_Chip-Seq_Bcells_Human1.64411080
36SUZ12_27294783_Chip-Seq_ESCs_Mouse1.61776417
37ZNF263_19887448_ChIP-Seq_K562_Human1.60784060
38SRY_22984422_ChIP-ChIP_TESTIS_Rat1.60251029
39MAF_26560356_Chip-Seq_TH2_Human1.59443925
40THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.59245703
41* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.58683297
42* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.57697316
43EZH2_18974828_ChIP-Seq_MESCs_Mouse1.55142010
44RNF2_18974828_ChIP-Seq_MESCs_Mouse1.55142010
45JARID2_20075857_ChIP-Seq_MESCs_Mouse1.54789652
46SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.54633443
47CTCF_27219007_Chip-Seq_Bcells_Human1.52455234
48ESR2_21235772_ChIP-Seq_MCF-7_Human1.52268638
49EZH2_27294783_Chip-Seq_ESCs_Mouse1.51601337
50* MAF_26560356_Chip-Seq_TH1_Human1.50932017
51RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.49727665
52REST_21632747_ChIP-Seq_MESCs_Mouse1.47705865
53REST_18959480_ChIP-ChIP_MESCs_Mouse1.45596055
54SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.43180197
55* UTX_26944678_Chip-Seq_JUKART_Human1.40758848
56CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.39601298
57RACK7_27058665_Chip-Seq_MCF-7_Human1.36669060
58KDM2B_26808549_Chip-Seq_DND41_Human1.36112269
59RARG_19884340_ChIP-ChIP_MEFs_Mouse1.35894833
60* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.35352726
61* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.35147390
62PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.34936929
63STAT6_21828071_ChIP-Seq_BEAS2B_Human1.34852380
64RUNX1_22412390_ChIP-Seq_EML_Mouse1.33871967
65* CREB1_26743006_Chip-Seq_LNCaP_Human1.30816590
66RNF2_27304074_Chip-Seq_ESCs_Mouse1.30797236
67SMC4_20622854_ChIP-Seq_HELA_Human1.30039099
68SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.30016878
69WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.29947673
70E2F1_20622854_ChIP-Seq_HELA_Human1.29765620
71PHF8_20622854_ChIP-Seq_HELA_Human1.28685152
72JARID2_20064375_ChIP-Seq_MESCs_Mouse1.28166511
73ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.27803055
74NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.27521693
75TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24527239
76* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.24039370
77GATA1_19941827_ChIP-Seq_MEL_Mouse1.24038580
78* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.22906997
79CTCF_26484167_Chip-Seq_Bcells_Mouse1.22460155
80NCOR1_26117541_ChIP-Seq_K562_Human1.22451796
81MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.19610055
82RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.18432245
83SA1_27219007_Chip-Seq_Bcells_Human1.17388356
84SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.16226262
85PU.1_20513432_ChIP-Seq_Bcells_Mouse1.16016576
86TP53_22127205_ChIP-Seq_IMR90_Human1.15922369
87ESR1_20079471_ChIP-ChIP_T-47D_Human1.15831714
88RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.15585565
89* SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.15479521
90TET1_21490601_ChIP-Seq_MESCs_Mouse1.15274727
91EZH2_27304074_Chip-Seq_ESCs_Mouse1.15079328
92WT1_25993318_ChIP-Seq_PODOCYTE_Human1.15012283
93P68_20966046_ChIP-Seq_HELA_Human1.14950960
94RARB_24833708_ChIP-Seq_LIVER_Mouse1.14756665
95SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.14713843
96KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.14647419
97* TET1_21451524_ChIP-Seq_MESCs_Mouse1.12543438
98TBX20_22080862_ChIP-Seq_HEART_Mouse1.12537643
99TBX20_22328084_ChIP-Seq_HEART_Mouse1.12537643
100GATA1_22383799_ChIP-Seq_G1ME_Mouse1.12456848
101RING1B_27294783_Chip-Seq_ESCs_Mouse1.11770536
102IKZF1_21737484_ChIP-ChIP_HCT116_Human1.11480149
103P300_27058665_Chip-Seq_ZR-75-30cells_Human1.11225432
104ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.11208864
105BRD4_27068464_Chip-Seq_AML-cells_Mouse1.10288327
106* CTCF_21964334_ChIP-Seq_BJAB-B_Human1.10254491
107SPI1_23127762_ChIP-Seq_K562_Human1.09732942
108TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.08433130
109GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07618218
110CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.07427403
111MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.07357674
112KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.06869162
113CTCF_21964334_Chip-Seq_Bcells_Human1.06399612
114RARA_24833708_ChIP-Seq_LIVER_Mouse1.05837857
115NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.05397813
116* YY1_22570637_ChIP-Seq_MALME-3M_Human1.05295639
117SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04843864
118TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04680651
119VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.03843391
120KDM2B_26808549_Chip-Seq_JURKAT_Human1.03828455
121KLF4_19829295_ChIP-Seq_ESCs_Human1.02705784
122TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.01717663
123ETS1_21867929_ChIP-Seq_TH2_Mouse1.01246323
124SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.01030305
125FOXA2_19822575_ChIP-Seq_HepG2_Human1.00739732
126CLOCK_20551151_ChIP-Seq_293T_Human1.00373475
127CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.00105054
128TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.00007451
129CTCF_20526341_ChIP-Seq_ESCs_Human0.99988651
130EED_16625203_ChIP-ChIP_MESCs_Mouse0.99012883
131TP63_22573176_ChIP-Seq_HFKS_Human0.99008064
132SA1_27219007_Chip-Seq_ERYTHROID_Human0.97846594
133EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.97753298
134* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.97170367
135CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.96121191
136EP300_21415370_ChIP-Seq_HL-1_Mouse0.95442457
137NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.94815680
138RUNX1_27514584_Chip-Seq_MCF-7_Human0.94501091
139* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.94227712
140OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.93533230
141* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.92650206
142* MYC_27129775_Chip-Seq_CORNEA_Mouse0.92209147
143* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91716831
144TP53_20018659_ChIP-ChIP_R1E_Mouse0.91678598
145* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.91335927
146* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.91082661
147UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.90610975
148RING1B_27294783_Chip-Seq_NPCs_Mouse0.90577867
149ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.89423719
150PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.89148520
151* OCT4_19829295_ChIP-Seq_ESCs_Human0.88937272
152TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.88519169

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology3.73349928
2MP0004859_abnormal_synaptic_plasticity3.63638803
3MP0002837_dystrophic_cardiac_calcinosis3.39260675
4MP0009278_abnormal_bone_marrow3.25467573
5MP0003436_decreased_susceptibility_to3.19823306
6MP0008260_abnormal_autophagy3.17500543
7MP0005451_abnormal_body_composition3.06066031
8MP0003172_abnormal_lysosome_physiology2.99928209
9MP0000751_myopathy2.93442479
10MP0002139_abnormal_hepatobiliary_system2.68767451
11MP0003303_peritoneal_inflammation2.55546333
12MP0005360_urolithiasis2.52679876
13MP0004130_abnormal_muscle_cell2.38357273
14MP0005085_abnormal_gallbladder_physiolo2.36971723
15MP0001849_ear_inflammation2.27421615
16MP0009780_abnormal_chondrocyte_physiolo2.23529898
17MP0002909_abnormal_adrenal_gland2.23224286
18MP0005365_abnormal_bile_salt2.19178109
19MP0003635_abnormal_synaptic_transmissio2.16960635
20MP0003329_amyloid_beta_deposits2.16352821
21MP0002249_abnormal_larynx_morphology2.13481356
22MP0004233_abnormal_muscle_weight2.12774355
23MP0003283_abnormal_digestive_organ2.07444727
24MP0004270_analgesia2.03336073
25MP0004043_abnormal_pH_regulation1.96872667
26MP0005076_abnormal_cell_differentiation1.95126571
27MP0002822_catalepsy1.79267851
28MP0004858_abnormal_nervous_system1.71045089
29MP0000678_abnormal_parathyroid_gland1.69366973
30MP0003646_muscle_fatigue1.68779993
31MP0004381_abnormal_hair_follicle1.66695831
32MP0002063_abnormal_learning/memory/cond1.66466399
33MP0003705_abnormal_hypodermis_morpholog1.64996458
34MP0002064_seizures1.62552953
35MP0004036_abnormal_muscle_relaxation1.62019832
36MP0005025_abnormal_response_to1.60593639
37MP0002419_abnormal_innate_immunity1.59477333
38MP0000013_abnormal_adipose_tissue1.58330517
39MP0000747_muscle_weakness1.58083741
40MP0004145_abnormal_muscle_electrophysio1.57165582
41MP0008961_abnormal_basal_metabolism1.56692955
42MP0001348_abnormal_lacrimal_gland1.55249366
43MP0000685_abnormal_immune_system1.55158921
44MP0004947_skin_inflammation1.54965104
45MP0002269_muscular_atrophy1.52907751
46MP0003195_calcinosis1.50456752
47MP0005332_abnormal_amino_acid1.50065890
48MP0004510_myositis1.49834829
49MP0003453_abnormal_keratinocyte_physiol1.49536270
50MP0003183_abnormal_peptide_metabolism1.49517097
51MP0001533_abnormal_skeleton_physiology1.48915713
52MP0005409_darkened_coat_color1.48640618
53MP0003252_abnormal_bile_duct1.45618142
54MP0004087_abnormal_muscle_fiber1.45312773
55MP0005330_cardiomyopathy1.44785794
56MP0009745_abnormal_behavioral_response1.43444561
57MP0010329_abnormal_lipoprotein_level1.41633386
58MP0008875_abnormal_xenobiotic_pharmacok1.39586788
59MP0003137_abnormal_impulse_conducting1.37615234
60MP0002933_joint_inflammation1.37005206
61MP0003724_increased_susceptibility_to1.36964731
62MP0009046_muscle_twitch1.35543819
63MP0004885_abnormal_endolymph1.35124973
64MP0009840_abnormal_foam_cell1.34381461
65MP0001958_emphysema1.32348817
66MP0001545_abnormal_hematopoietic_system1.31442539
67MP0005397_hematopoietic_system_phenotyp1.31442539
68MP0005666_abnormal_adipose_tissue1.31344895
69MP0004084_abnormal_cardiac_muscle1.30233968
70MP0005387_immune_system_phenotype1.30166994
71MP0001790_abnormal_immune_system1.30166994
72MP0000858_altered_metastatic_potential1.28687159
73MP0003279_aneurysm1.28185030
74MP0002572_abnormal_emotion/affect_behav1.28080306
75MP0002089_abnormal_postnatal_growth/wei1.27980253
76MP0001873_stomach_inflammation1.27658649
77MP0003633_abnormal_nervous_system1.26839820
78MP0002118_abnormal_lipid_homeostasis1.26075292
79MP0000749_muscle_degeneration1.25649046
80MP0002272_abnormal_nervous_system1.25458299
81MP0004215_abnormal_myocardial_fiber1.24567379
82MP0005410_abnormal_fertilization1.22844541
83MP0005000_abnormal_immune_tolerance1.20361532
84MP0004185_abnormal_adipocyte_glucose1.20132880
85MP0005083_abnormal_biliary_tract1.19771542
86MP0009333_abnormal_splenocyte_physiolog1.19117379
87MP0002733_abnormal_thermal_nociception1.19059605
88MP0008569_lethality_at_weaning1.18663355
89MP0005375_adipose_tissue_phenotype1.17623177
90MP0010155_abnormal_intestine_physiology1.16901191
91MP0001819_abnormal_immune_cell1.16842159
92MP0002420_abnormal_adaptive_immunity1.16825591
93MP0003880_abnormal_central_pattern1.16801669
94MP0002723_abnormal_immune_serum1.14670785
95MP0000003_abnormal_adipose_tissue1.12163167
96MP0002132_abnormal_respiratory_system1.11293153
97MP0001800_abnormal_humoral_immune1.10381591
98MP0003763_abnormal_thymus_physiology1.09843530
99MP0010234_abnormal_vibrissa_follicle1.07612728
100MP0005670_abnormal_white_adipose1.07081107
101MP0000759_abnormal_skeletal_muscle1.06952776
102MP0005620_abnormal_muscle_contractility1.05019718
103MP0000955_abnormal_spinal_cord1.04746190
104MP0005623_abnormal_meninges_morphology1.03192303
105MP0001970_abnormal_pain_threshold1.02623517
106MP0003075_altered_response_to1.01746401
107MP0003878_abnormal_ear_physiology1.01571469
108MP0005377_hearing/vestibular/ear_phenot1.01571469
109MP0003866_abnormal_defecation1.01379056
110MP0002078_abnormal_glucose_homeostasis0.99953463
111MP0002452_abnormal_antigen_presenting0.99436557
112MP0000681_abnormal_thyroid_gland0.99091286
113MP0005390_skeleton_phenotype0.98775507
114MP0000604_amyloidosis0.98488693
115MP0002106_abnormal_muscle_physiology0.97028467
116MP0009384_cardiac_valve_regurgitation0.96970643
117MP0001835_abnormal_antigen_presentation0.95812910
118MP0002734_abnormal_mechanical_nocicepti0.95596706
119MP0001765_abnormal_ion_homeostasis0.94699678
120MP0003690_abnormal_glial_cell0.94186888
121MP0001666_abnormal_nutrient_absorption0.94070432
122MP0004811_abnormal_neuron_physiology0.94036255
123MP0003879_abnormal_hair_cell0.93429302
124MP0004085_abnormal_heartbeat0.93042281
125MP0000750_abnormal_muscle_regeneration0.92785345
126MP0005535_abnormal_body_temperature0.92720214
127MP0000716_abnormal_immune_system0.92341546
128MP0001440_abnormal_grooming_behavior0.92211861
129MP0003045_fibrosis0.92189205
130MP0002066_abnormal_motor_capabilities/c0.92095427
131MP0002998_abnormal_bone_remodeling0.90977522
132MP0001968_abnormal_touch/_nociception0.89087044
133MP0002971_abnormal_brown_adipose0.88836381
134MP0010630_abnormal_cardiac_muscle0.88675386
135MP0003634_abnormal_glial_cell0.88179958
136MP0001486_abnormal_startle_reflex0.86652285
137MP0008874_decreased_physiological_sensi0.86098828
138MP0003631_nervous_system_phenotype0.85886015
139MP0006082_CNS_inflammation0.85640113
140MP0005584_abnormal_enzyme/coenzyme_acti0.85558443
141MP0000579_abnormal_nail_morphology0.84334675
142MP0005464_abnormal_platelet_physiology0.84176948
143MP0002398_abnormal_bone_marrow0.84165337
144MP0005167_abnormal_blood-brain_barrier0.83476081
145MP0002653_abnormal_ependyma_morphology0.82556821
146MP0002972_abnormal_cardiac_muscle0.81973748
147MP0005369_muscle_phenotype0.81933869
148MP0002067_abnormal_sensory_capabilities0.81374970
149MP0000534_abnormal_ureter_morphology0.80925608
150MP0000920_abnormal_myelination0.80774480
151MP0003091_abnormal_cell_migration0.80745417
152MP0002234_abnormal_pharynx_morphology0.80077072
153MP0003300_gastrointestinal_ulcer0.79758657
154MP0004924_abnormal_behavior0.79713803
155MP0005386_behavior/neurological_phenoty0.79713803
156MP0006036_abnormal_mitochondrial_physio0.77341278
157MP0002429_abnormal_blood_cell0.77022305
158MP0001663_abnormal_digestive_system0.76170506
159MP0002405_respiratory_system_inflammati0.76166137
160MP0005423_abnormal_somatic_nervous0.75688345
161MP0000733_abnormal_muscle_development0.75270539
162MP0001502_abnormal_circadian_rhythm0.75249031
163MP0003191_abnormal_cellular_cholesterol0.74714432
164MP0002882_abnormal_neuron_morphology0.74075199
165MP0002148_abnormal_hypersensitivity_rea0.74070562
166MP0000703_abnormal_thymus_morphology0.73946760
167MP0003566_abnormal_cell_adhesion0.71921040
168MP0002254_reproductive_system_inflammat0.71496127
169MP0010030_abnormal_orbit_morphology0.70137151
170MP0005501_abnormal_skin_physiology0.68549258
171MP0001845_abnormal_inflammatory_respons0.67360578
172MP0003123_paternal_imprinting0.67352002
173MP0002722_abnormal_immune_system0.66950986
174MP0009931_abnormal_skin_appearance0.66750575
175MP0005166_decreased_susceptibility_to0.66029293

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)3.89731622
2Obstructive sleep apnea (HP:0002870)3.88985668
3Myokymia (HP:0002411)3.52962570
4Ketoacidosis (HP:0001993)3.51769059
5Broad face (HP:0000283)3.41755241
6Myoglobinuria (HP:0002913)3.18523690
7Stridor (HP:0010307)3.13876161
8Ketosis (HP:0001946)3.09003408
9Sudden death (HP:0001699)3.06214837
10Hyperacusis (HP:0010780)3.02195374
11Eczematoid dermatitis (HP:0000976)2.97897848
12Cervical subluxation (HP:0003308)2.97815722
13J-shaped sella turcica (HP:0002680)2.94278808
14Turricephaly (HP:0000262)2.94227774
15Bundle branch block (HP:0011710)2.81142807
16Gout (HP:0001997)2.73484770
17Increased cerebral lipofuscin (HP:0011813)2.71153767
18Metaphyseal cupping (HP:0003021)2.70338499
19Thin bony cortex (HP:0002753)2.66825254
20Pheochromocytoma (HP:0002666)2.66820509
21Exercise-induced muscle cramps (HP:0003710)2.63764652
22Asymmetric septal hypertrophy (HP:0001670)2.63300527
23Abnormality of the lower motor neuron (HP:0002366)2.63117565
24Dysostosis multiplex (HP:0000943)2.61110703
25Distal lower limb muscle weakness (HP:0009053)2.59356307
26Hyperthyroidism (HP:0000836)2.59222063
27Cerebral inclusion bodies (HP:0100314)2.55697702
28Hyporeflexia of lower limbs (HP:0002600)2.54085666
29Increased neuronal autofluorescent lipopigment (HP:0002074)2.53296120
30Chronic obstructive pulmonary disease (HP:0006510)2.51147185
31Obstructive lung disease (HP:0006536)2.51147185
32Easy fatigability (HP:0003388)2.50675819
33Myopathic facies (HP:0002058)2.48994060
34Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.48732319
35Large for gestational age (HP:0001520)2.47649925
36Visual hallucinations (HP:0002367)2.46545612
37Neurofibrillary tangles (HP:0002185)2.44578048
38Colitis (HP:0002583)2.43546352
39Vertebral compression fractures (HP:0002953)2.43398297
40Hypertensive crisis (HP:0100735)2.41230866
41Ulnar bowing (HP:0003031)2.40799876
42Increased IgE level (HP:0003212)2.40620349
43Cellulitis (HP:0100658)2.39177542
44Increased connective tissue (HP:0009025)2.39029669
45Abnormality of the Achilles tendon (HP:0005109)2.38152923
46Joint stiffness (HP:0001387)2.37803128
47Difficulty running (HP:0009046)2.37548004
48Biconcave vertebral bodies (HP:0004586)2.36078767
49Hypercortisolism (HP:0001578)2.34485825
50Truncus arteriosus (HP:0001660)2.33897232
51Deep venous thrombosis (HP:0002625)2.28897274
52Achilles tendon contracture (HP:0001771)2.28053385
53Atelectasis (HP:0100750)2.27470872
54Xanthomatosis (HP:0000991)2.27079916
55Supranuclear gaze palsy (HP:0000605)2.26471634
56Abnormality of aromatic amino acid family metabolism (HP:0004338)2.25956198
57Hemorrhage of the eye (HP:0011885)2.25860354
58Late onset (HP:0003584)2.23655747
59Abnormality of polysaccharide metabolism (HP:0011012)2.22567106
60Abnormality of glycosaminoglycan metabolism (HP:0004371)2.22567106
61Abnormality of mucopolysaccharide metabolism (HP:0011020)2.22567106
62Recurrent abscess formation (HP:0002722)2.22168649
63Distal lower limb amyotrophy (HP:0008944)2.22097969
64Focal motor seizures (HP:0011153)2.22069117
65Ventricular fibrillation (HP:0001663)2.21772418
66Neuroendocrine neoplasm (HP:0100634)2.21126466
67Abnormal gallbladder physiology (HP:0012438)2.20456847
68Cholecystitis (HP:0001082)2.20456847
69Flattened epiphyses (HP:0003071)2.20359086
70Hypochromic anemia (HP:0001931)2.18601342
71Abnormality of macrophages (HP:0004311)2.17807025
72Distal upper limb amyotrophy (HP:0007149)2.17679910
73Upper limb amyotrophy (HP:0009129)2.17679910
74Global brain atrophy (HP:0002283)2.17197639
75Annular pancreas (HP:0001734)2.17045789
76Action tremor (HP:0002345)2.16963540
77Cerebral aneurysm (HP:0004944)2.15675342
78Hypoglycemic coma (HP:0001325)2.13780835
79Mucopolysacchariduria (HP:0008155)2.13117044
80Urinary glycosaminoglycan excretion (HP:0003541)2.13117044
81Myotonia (HP:0002486)2.11887975
82Polygenic inheritance (HP:0010982)2.10959471
83Hyperglycinuria (HP:0003108)2.10409740
84Increased variability in muscle fiber diameter (HP:0003557)2.09994165
85Dysmetric saccades (HP:0000641)2.08305054
86Heart block (HP:0012722)2.08246415
87Hyperammonemia (HP:0001987)2.07907461
88Focal seizures (HP:0007359)2.05873642
89Abnormality of the thoracic spine (HP:0100711)2.05642255
90Resting tremor (HP:0002322)2.05505976
91Increased serum ferritin (HP:0003281)2.04154766
92Flat acetabular roof (HP:0003180)2.03984582
93Hypertriglyceridemia (HP:0002155)2.03511977
94Hyperinsulinemic hypoglycemia (HP:0000825)2.03407690
95Muscle fiber splitting (HP:0003555)2.03207556
96Recurrent bacterial skin infections (HP:0005406)2.03125279
97Neuronal loss in central nervous system (HP:0002529)2.03090428
98Abnormality of glycine metabolism (HP:0010895)2.02554699
99Abnormality of serine family amino acid metabolism (HP:0010894)2.02554699
100Depression (HP:0000716)2.02276516
101Mitral regurgitation (HP:0001653)2.01848008
102Centrally nucleated skeletal muscle fibers (HP:0003687)2.01719147
103Broad distal phalanx of finger (HP:0009836)2.01536035
104Gingivitis (HP:0000230)2.01439258
105Gastrointestinal inflammation (HP:0004386)2.01358822
106Segmental peripheral demyelination/remyelination (HP:0003481)1.98682746
107Ankle clonus (HP:0011448)1.98556592
108Flat capital femoral epiphysis (HP:0003370)1.98066674
109Insidious onset (HP:0003587)1.97808956
110Termporal pattern (HP:0011008)1.97808956
111Myositis (HP:0100614)1.97565499
112Thoracic kyphosis (HP:0002942)1.95442971
113Atrioventricular block (HP:0001678)1.95161997
114Rapidly progressive (HP:0003678)1.95013470
115Seborrheic dermatitis (HP:0001051)1.94606916
116Torticollis (HP:0000473)1.93297209
117Hamartoma of the eye (HP:0010568)1.93014375
118Megalencephaly (HP:0001355)1.92899740
119Nuclear cataract (HP:0100018)1.91758209
120Abnormal atrioventricular conduction (HP:0005150)1.91553235
121Insomnia (HP:0100785)1.91071716
122Calf muscle hypertrophy (HP:0008981)1.91013653
123Reticulocytosis (HP:0001923)1.90549808
124Atonic seizures (HP:0010819)1.88334668
125Male infertility (HP:0003251)1.87974679
126Anxiety (HP:0000739)1.87946081
127Abnormality of liposaccharide metabolism (HP:0010968)1.87751591
128Abnormality of glycosphingolipid metabolism (HP:0004343)1.87751591
129Abnormality of glycolipid metabolism (HP:0010969)1.87751591
130Spinal canal stenosis (HP:0003416)1.87618061
131Disproportionate tall stature (HP:0001519)1.87520123
132Muscle hypertrophy of the lower extremities (HP:0008968)1.87363581
133Hand muscle atrophy (HP:0009130)1.87028782
134Status epilepticus (HP:0002133)1.86931528
135Back pain (HP:0003418)1.86853343
136Prolonged QT interval (HP:0001657)1.86710572
137Lymphangioma (HP:0100764)1.86601223
138Abnormality of the nasal mucosa (HP:0000433)1.86145778
139Syncope (HP:0001279)1.84910118
140Intention tremor (HP:0002080)1.84832098
141Nasal polyposis (HP:0100582)1.84678012
142Abnormal social behavior (HP:0012433)1.84470025
143Impaired social interactions (HP:0000735)1.84470025
144Gastrointestinal infarctions (HP:0005244)1.84305756
145Abnormality of the calf musculature (HP:0001430)1.84232106
146Protrusio acetabuli (HP:0003179)1.84115131
147Cholelithiasis (HP:0001081)1.82920775
148Focal dystonia (HP:0004373)1.82649870
149Impaired vibration sensation in the lower limbs (HP:0002166)1.82467202
150Bowel incontinence (HP:0002607)1.82393491
151Hyperglycinemia (HP:0002154)1.82320896
152Urinary urgency (HP:0000012)1.82150971
153Postural instability (HP:0002172)1.80869213
154Polycythemia (HP:0001901)1.80079626
155Neoplasm of the peripheral nervous system (HP:0100007)1.79237905
156Difficulty climbing stairs (HP:0003551)1.79014223
157Dysdiadochokinesis (HP:0002075)1.78912873
158Craniofacial dystonia (HP:0012179)1.78150822
159Hyperlipoproteinemia (HP:0010980)1.77758205
160Intrahepatic cholestasis (HP:0001406)1.77040655
161Abnormal gallbladder morphology (HP:0012437)1.76260784
162Purpura (HP:0000979)1.75868712
163Loss of speech (HP:0002371)1.75704544
164Amyloidosis (HP:0011034)1.75270059
165Shallow orbits (HP:0000586)1.75003208
166Bulbar palsy (HP:0001283)1.74677496
167Ventricular arrhythmia (HP:0004308)1.74549008
168Slow saccadic eye movements (HP:0000514)1.74316677
169Growth hormone excess (HP:0000845)1.74301152
170Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.74179826
171Long toe (HP:0010511)1.73556850
172Muscle stiffness (HP:0003552)1.73402119
173Mediastinal lymphadenopathy (HP:0100721)1.73084151
174EMG: neuropathic changes (HP:0003445)1.72954110
175Increased circulating renin level (HP:0000848)1.72742421
176Onion bulb formation (HP:0003383)1.72588719
177Pointed chin (HP:0000307)1.72499563
178Neonatal onset (HP:0003623)1.72206147
179Foot dorsiflexor weakness (HP:0009027)1.71818504
180Inflammation of the large intestine (HP:0002037)1.71346219
181Thin ribs (HP:0000883)1.71229361
182Dysmetria (HP:0001310)1.69142896
183Athetosis (HP:0002305)1.68183217

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.72996751
2ICK3.00049432
3PRKD32.76728123
4SMG12.61397998
5PHKG22.28735700
6PHKG12.28735700
7MAP2K32.23336332
8TNK22.14305843
9DDR22.12479422
10PINK12.07336516
11MAP4K12.03195297
12PKN22.00096739
13EPHA41.99948581
14PDK41.97666149
15PDK31.97666149
16MAP3K91.96545019
17LMTK21.95720350
18TYRO31.85586355
19RIPK41.76694974
20PDGFRA1.75300463
21WNK41.71234609
22MAPK151.70719605
23KSR21.68892444
24NTRK31.64842308
25DAPK21.64672008
26UHMK11.56985782
27EPHA21.55821647
28TTN1.55246704
29PAK61.51440689
30BCKDK1.50385632
31RIPK11.45133942
32STK381.42978235
33NTRK11.42755431
34MAP3K41.35137413
35NME21.34656409
36TESK21.31431613
37BLK1.25933744
38PRKD21.25171427
39SIK11.19576102
40IRAK31.19561278
41MAP3K71.16368594
42CAMKK11.16141795
43MAP3K21.14058253
44DMPK1.13646006
45TBK11.13501918
46BMX1.11700005
47MAP3K61.11547492
48DAPK11.09982614
49MINK11.09745711
50ZAP701.08131781
51FGFR41.06780214
52TYK21.06628871
53TAOK11.06272011
54GRK61.04581999
55ERN11.03076270
56WNK30.99467237
57DYRK1B0.99407788
58RPS6KC10.99095518
59RPS6KL10.99095518
60MAP3K130.99052382
61RPS6KA20.98915944
62MAP2K40.97663492
63MAP3K30.97107440
64LATS20.96645967
65RET0.96105645
66IRAK40.95843792
67MARK10.95497564
68MAPK120.93978635
69MAP2K60.93376031
70FES0.92044710
71CDC42BPA0.91684792
72WNK10.90958601
73PRKCH0.90942064
74PDK20.90833351
75CSK0.90513292
76STK390.86519985
77PTK60.86098101
78MAP3K110.85232168
79CDK50.84892461
80TAOK20.82469389
81NTRK20.82445343
82DAPK30.82433663
83RPS6KA60.81265303
84PRKD10.80591412
85PTK2B0.80490829
86MAP2K20.80172697
87SIK30.79572939
88CDK120.79306500
89PDPK10.77858323
90MAP3K100.77014054
91PAK30.76786132
92FGR0.76614945
93OXSR10.75148499
94MARK20.73926580
95MST1R0.72732421
96NME10.72511555
97PTK20.70077581
98ARAF0.68819219
99JAK30.67961606
100BTK0.66303573
101PRKAA10.65471680
102MAP3K10.64748904
103SGK2230.64000771
104SGK4940.64000771
105FER0.63473553
106PDK10.63420025
107CAMK2G0.62636178
108LRRK20.62406948
109SIK20.61488297
110PRPF4B0.60332445
111SGK30.59532413
112CAMK2B0.59000466
113CAMK2D0.58660846
114HCK0.58182366
115CAMK2A0.56795663
116EEF2K0.56778119
117MAPK110.54675741
118STK110.53643188
119CSF1R0.53321745
120ILK0.51697567
121GRK50.50843872
122CAMK1G0.50730595
123PRKCZ0.50426249
124MTOR0.48814010
125GSK3A0.48285907
126NEK10.47922524
127INSRR0.47480657
128EPHB10.46333609
129PAK40.45435056
130SGK10.45046360
131IKBKB0.44169067
132ALK0.43447629
133PDGFRB0.42964115
134TESK10.42764811
135PRKG20.42334123
136FGFR20.42299280
137ROCK10.42046589
138MAPK70.40714246
139CDK150.40390127
140KSR10.40045011
141IRAK20.39619318
142HIPK20.39295091
143KDR0.38666882
144IKBKE0.37892004
145RPS6KA10.37350188
146MAPKAPK30.37163706
147SYK0.37028151
148BRAF0.36123604
149MAPK40.35995825
150JAK20.35373443

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005113.60404006
2Nitrogen metabolism_Homo sapiens_hsa009102.93797874
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.41981526
4Notch signaling pathway_Homo sapiens_hsa043302.26578273
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.18605172
6Fatty acid biosynthesis_Homo sapiens_hsa000612.17329064
7Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.13853679
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.10508494
9Acute myeloid leukemia_Homo sapiens_hsa052212.02263767
10Cyanoamino acid metabolism_Homo sapiens_hsa004601.98761345
11Fatty acid metabolism_Homo sapiens_hsa012121.97272269
12Propanoate metabolism_Homo sapiens_hsa006401.95957337
13Fatty acid degradation_Homo sapiens_hsa000711.94013135
14Glycosaminoglycan degradation_Homo sapiens_hsa005311.89884426
15Butanoate metabolism_Homo sapiens_hsa006501.86865009
16Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.86809041
17Arginine biosynthesis_Homo sapiens_hsa002201.80331772
18Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.77577417
19Osteoclast differentiation_Homo sapiens_hsa043801.75076279
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.71056879
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.66034236
22B cell receptor signaling pathway_Homo sapiens_hsa046621.60658901
23Non-small cell lung cancer_Homo sapiens_hsa052231.58257289
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.55456977
25Chronic myeloid leukemia_Homo sapiens_hsa052201.50188057
26Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.49122252
27Bile secretion_Homo sapiens_hsa049761.43640560
28Pyruvate metabolism_Homo sapiens_hsa006201.42723723
29Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.40340372
30Leishmaniasis_Homo sapiens_hsa051401.40125896
31Synaptic vesicle cycle_Homo sapiens_hsa047211.36030198
32Neurotrophin signaling pathway_Homo sapiens_hsa047221.33981754
33PPAR signaling pathway_Homo sapiens_hsa033201.33442963
34Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.33290030
35Insulin secretion_Homo sapiens_hsa049111.32409213
36Primary bile acid biosynthesis_Homo sapiens_hsa001201.30595049
37Phospholipase D signaling pathway_Homo sapiens_hsa040721.25163695
38Toll-like receptor signaling pathway_Homo sapiens_hsa046201.25037134
39Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.23819324
40Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.23651245
41GABAergic synapse_Homo sapiens_hsa047271.21585641
42Carbon metabolism_Homo sapiens_hsa012001.18797192
43Gastric acid secretion_Homo sapiens_hsa049711.16218607
44Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.16119091
45Lysosome_Homo sapiens_hsa041421.15151788
46Sulfur metabolism_Homo sapiens_hsa009201.14481612
47Tryptophan metabolism_Homo sapiens_hsa003801.13206693
48Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.13090144
49Choline metabolism in cancer_Homo sapiens_hsa052311.12489765
50Endocytosis_Homo sapiens_hsa041441.11696178
51Tuberculosis_Homo sapiens_hsa051521.10898374
52Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.09963147
53Long-term potentiation_Homo sapiens_hsa047201.08054784
54Hepatitis C_Homo sapiens_hsa051601.07492494
55RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.06585356
56Endometrial cancer_Homo sapiens_hsa052131.05992271
57Glycerophospholipid metabolism_Homo sapiens_hsa005641.05712561
58Cardiac muscle contraction_Homo sapiens_hsa042601.05615333
59Circadian entrainment_Homo sapiens_hsa047131.05543607
60Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.04717120
61Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.04231919
62Phosphatidylinositol signaling system_Homo sapiens_hsa040701.02962922
63Olfactory transduction_Homo sapiens_hsa047401.02745398
64Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.01542329
65Biosynthesis of amino acids_Homo sapiens_hsa012301.00291705
66Prion diseases_Homo sapiens_hsa050201.00214377
67Amphetamine addiction_Homo sapiens_hsa050310.99375163
68Staphylococcus aureus infection_Homo sapiens_hsa051500.98753312
69Thyroid hormone signaling pathway_Homo sapiens_hsa049190.98293535
70Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.98095636
71Fat digestion and absorption_Homo sapiens_hsa049750.97301561
72Salivary secretion_Homo sapiens_hsa049700.97217506
73Glucagon signaling pathway_Homo sapiens_hsa049220.97107038
74Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.96653874
75Inositol phosphate metabolism_Homo sapiens_hsa005620.96401350
76Pentose phosphate pathway_Homo sapiens_hsa000300.95366560
77Prolactin signaling pathway_Homo sapiens_hsa049170.95228593
78Leukocyte transendothelial migration_Homo sapiens_hsa046700.93152826
79Aldosterone synthesis and secretion_Homo sapiens_hsa049250.91996016
80Toxoplasmosis_Homo sapiens_hsa051450.91895570
81Pancreatic cancer_Homo sapiens_hsa052120.91622152
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.91251887
83Glutamatergic synapse_Homo sapiens_hsa047240.91244785
84TNF signaling pathway_Homo sapiens_hsa046680.90070403
85AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.87267860
86Type II diabetes mellitus_Homo sapiens_hsa049300.86687090
87Maturity onset diabetes of the young_Homo sapiens_hsa049500.86373250
88Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.86364580
89Dilated cardiomyopathy_Homo sapiens_hsa054140.86205768
90Insulin signaling pathway_Homo sapiens_hsa049100.86030475
91Renin secretion_Homo sapiens_hsa049240.85523610
92Morphine addiction_Homo sapiens_hsa050320.84841934
93Dopaminergic synapse_Homo sapiens_hsa047280.84450164
94Chemokine signaling pathway_Homo sapiens_hsa040620.81971914
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.80921468
96Glycerolipid metabolism_Homo sapiens_hsa005610.79981596
97beta-Alanine metabolism_Homo sapiens_hsa004100.79864169
98T cell receptor signaling pathway_Homo sapiens_hsa046600.78662375
99Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.78018756
100Nicotine addiction_Homo sapiens_hsa050330.77491221
101Influenza A_Homo sapiens_hsa051640.76703896
102Carbohydrate digestion and absorption_Homo sapiens_hsa049730.76533096
103Gap junction_Homo sapiens_hsa045400.75468514
104Oxytocin signaling pathway_Homo sapiens_hsa049210.75303896
105Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.75011534
106Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.73322516
107Renal cell carcinoma_Homo sapiens_hsa052110.73109266
108Estrogen signaling pathway_Homo sapiens_hsa049150.72578798
109Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.72526784
110Starch and sucrose metabolism_Homo sapiens_hsa005000.71573273
111Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71179278
112Dorso-ventral axis formation_Homo sapiens_hsa043200.71039397
113Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70794712
114Cholinergic synapse_Homo sapiens_hsa047250.70662393
115Apoptosis_Homo sapiens_hsa042100.70532445
116Adipocytokine signaling pathway_Homo sapiens_hsa049200.70271982
117mTOR signaling pathway_Homo sapiens_hsa041500.69506171
118Lysine degradation_Homo sapiens_hsa003100.69204982
119Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68928015
120MAPK signaling pathway_Homo sapiens_hsa040100.68276136
121Cocaine addiction_Homo sapiens_hsa050300.66567697
122Arginine and proline metabolism_Homo sapiens_hsa003300.66495899
123Fatty acid elongation_Homo sapiens_hsa000620.66347454
124AMPK signaling pathway_Homo sapiens_hsa041520.65895686
125Longevity regulating pathway - mammal_Homo sapiens_hsa042110.65771037
126Insulin resistance_Homo sapiens_hsa049310.65338507
127Hepatitis B_Homo sapiens_hsa051610.64825416
128Malaria_Homo sapiens_hsa051440.64549183
129GnRH signaling pathway_Homo sapiens_hsa049120.63804051
130Taste transduction_Homo sapiens_hsa047420.63759421
131Pancreatic secretion_Homo sapiens_hsa049720.63754674
132Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.63697667
133cGMP-PKG signaling pathway_Homo sapiens_hsa040220.63498561
134Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.62407540
135Thyroid hormone synthesis_Homo sapiens_hsa049180.61801560
136Salmonella infection_Homo sapiens_hsa051320.61570590
137Galactose metabolism_Homo sapiens_hsa000520.59979487
138Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.59496518
139VEGF signaling pathway_Homo sapiens_hsa043700.59464756
140Peroxisome_Homo sapiens_hsa041460.59415406
141Glioma_Homo sapiens_hsa052140.59162123
142Shigellosis_Homo sapiens_hsa051310.58721729
143Amoebiasis_Homo sapiens_hsa051460.58221027
144Rap1 signaling pathway_Homo sapiens_hsa040150.58129625
145Viral myocarditis_Homo sapiens_hsa054160.57655308
146Sulfur relay system_Homo sapiens_hsa041220.57583807
147Calcium signaling pathway_Homo sapiens_hsa040200.56592288
148cAMP signaling pathway_Homo sapiens_hsa040240.56383906
149Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55492460
150NF-kappa B signaling pathway_Homo sapiens_hsa040640.55346066
151Fructose and mannose metabolism_Homo sapiens_hsa000510.55249849
152Central carbon metabolism in cancer_Homo sapiens_hsa052300.54989350
153Vascular smooth muscle contraction_Homo sapiens_hsa042700.54890711
154Melanogenesis_Homo sapiens_hsa049160.54886173
155Platelet activation_Homo sapiens_hsa046110.54749810
156Focal adhesion_Homo sapiens_hsa045100.53477768
157Bladder cancer_Homo sapiens_hsa052190.53199574
158Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.52410031
159Long-term depression_Homo sapiens_hsa047300.50398050
160HTLV-I infection_Homo sapiens_hsa051660.50052163
161HIF-1 signaling pathway_Homo sapiens_hsa040660.49887431
162FoxO signaling pathway_Homo sapiens_hsa040680.49713427
163Pertussis_Homo sapiens_hsa051330.49144866
164Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47067803
165ErbB signaling pathway_Homo sapiens_hsa040120.45647861
166Measles_Homo sapiens_hsa051620.45012421
167ABC transporters_Homo sapiens_hsa020100.44967745
168Graft-versus-host disease_Homo sapiens_hsa053320.44661703
169Circadian rhythm_Homo sapiens_hsa047100.44485701

Most similar genes based on co-expression Upload to Enrichr

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