CYLC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Cylicin II (CYCL2) is specifically expressed in testis and is part of the cytoskeletal calyx of mammalian sperm heads. Cylicin II may play a role in the morphogenesis of the sperm head. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1spermatid development (GO:0007286)9.56371142
2regulation of cilium movement (GO:0003352)9.35204937
3motile cilium assembly (GO:0044458)9.16794689
4cilium movement (GO:0003341)8.45071986
5single fertilization (GO:0007338)8.23728632
6epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.90274018
7response to pheromone (GO:0019236)7.84928873
8sperm capacitation (GO:0048240)7.62713012
9male meiosis (GO:0007140)7.56381636
10piRNA metabolic process (GO:0034587)7.28907300
11synaptonemal complex organization (GO:0070193)6.97192522
12fertilization (GO:0009566)6.77403858
13synaptonemal complex assembly (GO:0007130)6.63909700
14negative regulation of inclusion body assembly (GO:0090084)6.48398248
15microtubule depolymerization (GO:0007019)6.28550876
16* spermatogenesis (GO:0007283)6.20405351
17* male gamete generation (GO:0048232)6.18094748
18organic cation transport (GO:0015695)5.94265805
19ventricular system development (GO:0021591)5.77145876
20* gamete generation (GO:0007276)5.68143836
21cellular ketone body metabolic process (GO:0046950)5.65162494
22establishment of protein localization to Golgi (GO:0072600)5.55991171
23regulation of microtubule-based movement (GO:0060632)5.54464028
24protein targeting to Golgi (GO:0000042)5.47668594
25calcium ion-dependent exocytosis (GO:0017156)5.44508292
26cellular process involved in reproduction in multicellular organism (GO:0022412)5.37995325
27regulation of inclusion body assembly (GO:0090083)5.36683835
28germ cell development (GO:0007281)5.31804177
29male meiosis I (GO:0007141)5.13742383
30cell recognition (GO:0008037)5.12728675
31retrograde transport, vesicle recycling within Golgi (GO:0000301)5.09475586
32ketone body metabolic process (GO:1902224)4.98751210
33rRNA methylation (GO:0031167)4.88610063
34phosphatidylethanolamine biosynthetic process (GO:0006646)4.81010586
35spermatid nucleus differentiation (GO:0007289)4.79597749
36glycerol ether metabolic process (GO:0006662)4.74626863
37DNA methylation involved in gamete generation (GO:0043046)4.65544801
38microtubule severing (GO:0051013)4.64646489
39chromosome organization involved in meiosis (GO:0070192)4.63057506
40phosphatidylethanolamine metabolic process (GO:0046337)4.50653914
41* multicellular organismal reproductive process (GO:0048609)4.49754362
42ether metabolic process (GO:0018904)4.38512668
43positive regulation of Rab GTPase activity (GO:0032851)4.37997225
44regulation of Rab GTPase activity (GO:0032313)4.37997225
45meiotic nuclear division (GO:0007126)4.34142096
46left/right pattern formation (GO:0060972)4.30783981
47protein localization to Golgi apparatus (GO:0034067)4.27681364
48rRNA modification (GO:0000154)4.11657244
49seminiferous tubule development (GO:0072520)4.11220946
50meiosis I (GO:0007127)4.07305666
51monoubiquitinated protein deubiquitination (GO:0035520)3.99544332
52coenzyme catabolic process (GO:0009109)3.92626199
53regulation of transcription involved in cell fate commitment (GO:0060850)3.88053820
54genitalia morphogenesis (GO:0035112)3.85867602
55chromosome condensation (GO:0030261)3.84196939
56protein polyglutamylation (GO:0018095)3.76492010
57NAD biosynthetic process (GO:0009435)3.73366907
58RNA destabilization (GO:0050779)3.71567254
59chaperone-mediated protein complex assembly (GO:0051131)3.68177214
60DNA packaging (GO:0006323)3.62067981
61* multicellular organismal development (GO:0007275)3.59235597
62negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.53665220
63pattern specification involved in kidney development (GO:0061004)3.50744008
64protein localization to cilium (GO:0061512)3.33438418
65sexual reproduction (GO:0019953)3.33136712
66protein refolding (GO:0042026)3.32504853
67multicellular organismal movement (GO:0050879)3.32450265
68musculoskeletal movement (GO:0050881)3.32450265
69single strand break repair (GO:0000012)3.32093703
70negative regulation of Rho protein signal transduction (GO:0035024)3.27777899
71microtubule polymerization or depolymerization (GO:0031109)3.26447120
72meiotic cell cycle (GO:0051321)3.25428895
73glycolytic process (GO:0006096)3.24894291
74spinal cord motor neuron differentiation (GO:0021522)3.22437133
75carnitine transport (GO:0015879)3.12749466
76amino-acid betaine transport (GO:0015838)3.12749466
77Golgi to endosome transport (GO:0006895)3.11700504
78appendage development (GO:0048736)3.07578714
79limb development (GO:0060173)3.07578714
80tachykinin receptor signaling pathway (GO:0007217)3.07091119
81cerebral cortex neuron differentiation (GO:0021895)3.06351121
82regulation of interleukin-13 production (GO:0032656)3.06172904
83detection of light stimulus involved in sensory perception (GO:0050962)3.05607697
84detection of light stimulus involved in visual perception (GO:0050908)3.05607697
85cilium organization (GO:0044782)3.04637514
86microtubule-based movement (GO:0007018)3.04440327
87regulation of spindle checkpoint (GO:0090231)3.02332673
88positive regulation of guanylate cyclase activity (GO:0031284)2.99678494
89lactate metabolic process (GO:0006089)2.98927708
90microtubule nucleation (GO:0007020)2.98834527
91nucleus organization (GO:0006997)2.97104146
92carnitine transmembrane transport (GO:1902603)2.97051804
93nucleoside diphosphate phosphorylation (GO:0006165)2.96095191
94negative regulation of organelle assembly (GO:1902116)2.95339330
95intraciliary transport (GO:0042073)2.92372413
96polyol catabolic process (GO:0046174)2.91881078
97synapsis (GO:0007129)2.91400595
98cilium assembly (GO:0042384)2.91198377
99protein K11-linked deubiquitination (GO:0035871)2.90177970
100cell differentiation involved in metanephros development (GO:0072202)2.89657014
101regulation of guanylate cyclase activity (GO:0031282)2.88475710
102centriole assembly (GO:0098534)2.87240480
103mesenchymal cell differentiation involved in kidney development (GO:0072161)2.82408691
104mesenchymal cell differentiation involved in renal system development (GO:2001012)2.82408691
105cellular component assembly involved in morphogenesis (GO:0010927)2.82294827
106alditol metabolic process (GO:0019400)2.82265149
107detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.79324329
108nonmotile primary cilium assembly (GO:0035058)2.79148119
109nicotinamide nucleotide biosynthetic process (GO:0019359)2.78946423
110pyridine nucleotide biosynthetic process (GO:0019363)2.78946423
111primary amino compound metabolic process (GO:1901160)2.78885398
112nuclear pore complex assembly (GO:0051292)2.77157657
113cAMP catabolic process (GO:0006198)2.76232409
114chromatin silencing (GO:0006342)2.75453462
115GTP biosynthetic process (GO:0006183)2.75440435
116axoneme assembly (GO:0035082)2.75168987
117meiotic cell cycle process (GO:1903046)2.75156005
118mitotic sister chromatid cohesion (GO:0007064)2.74350011
119G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.73014047
120tryptophan catabolic process (GO:0006569)2.72739976
121indole-containing compound catabolic process (GO:0042436)2.72739976
122indolalkylamine catabolic process (GO:0046218)2.72739976
123calcium ion import (GO:0070509)2.70990720
124gene silencing by RNA (GO:0031047)2.65574175
125cilium morphogenesis (GO:0060271)2.64383457
126regulation of centriole replication (GO:0046599)2.60774193
127RNA localization (GO:0006403)2.57576051
128regulation of protein kinase A signaling (GO:0010738)2.53723937
129peptidyl-glutamic acid modification (GO:0018200)2.52516912
130regulation of protein kinase C signaling (GO:0090036)2.50905242
131centriole replication (GO:0007099)2.50776779
132regulation of meiosis I (GO:0060631)2.50711194
133negative regulation of skeletal muscle tissue development (GO:0048642)2.49311194
134fusion of sperm to egg plasma membrane (GO:0007342)14.8386947
135sperm motility (GO:0030317)14.0382710
136multicellular organism reproduction (GO:0032504)12.3633444
137cilium or flagellum-dependent cell motility (GO:0001539)11.9407670
138cell wall macromolecule metabolic process (GO:0044036)11.9188305
139cell wall macromolecule catabolic process (GO:0016998)11.9188305
140sperm-egg recognition (GO:0035036)11.7004840
141acrosome reaction (GO:0007340)11.6826284
142acrosome assembly (GO:0001675)11.5337108
143plasma membrane fusion (GO:0045026)11.3332377
144cell-cell recognition (GO:0009988)10.4795908
145reproduction (GO:0000003)10.3562384
146binding of sperm to zona pellucida (GO:0007339)10.2287448
147axonemal dynein complex assembly (GO:0070286)10.2202084
148epithelial cilium movement (GO:0003351)10.0929133

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.99788832
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.59691177
3EZH2_22144423_ChIP-Seq_EOC_Human4.34556760
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.54729823
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.94917555
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.77014990
7GBX2_23144817_ChIP-Seq_PC3_Human2.50189547
8* CTBP1_25329375_ChIP-Seq_LNCAP_Human2.42954405
9VDR_22108803_ChIP-Seq_LS180_Human2.42267417
10* FUS_26573619_Chip-Seq_HEK293_Human2.30177630
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.27901532
12STAT6_21828071_ChIP-Seq_BEAS2B_Human2.25861226
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.12799940
14* TAF15_26573619_Chip-Seq_HEK293_Human2.11306611
15CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.09295103
16ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.07036781
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.06758016
18P300_19829295_ChIP-Seq_ESCs_Human1.97722797
19EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.95858477
20ER_23166858_ChIP-Seq_MCF-7_Human1.94240367
21PCGF2_27294783_Chip-Seq_ESCs_Mouse1.92296828
22ZNF274_21170338_ChIP-Seq_K562_Hela1.89899481
23* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.88787835
24KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.82157147
25TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.82144034
26SALL1_21062744_ChIP-ChIP_HESCs_Human1.80934422
27CBX2_27304074_Chip-Seq_ESCs_Mouse1.80143311
28GATA1_26923725_Chip-Seq_HPCs_Mouse1.78282406
29RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.73865027
30STAT1_17558387_ChIP-Seq_HELA_Human1.69937289
31* AR_25329375_ChIP-Seq_VCAP_Human1.67996916
32SMAD3_21741376_ChIP-Seq_EPCs_Human1.67156087
33ELK4_26923725_Chip-Seq_MESODERM_Mouse1.65352534
34MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.63210672
35GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.62612107
36WDR5_24793694_ChIP-Seq_LNCAP_Human1.60607767
37STAT3_23295773_ChIP-Seq_U87_Human1.59037412
38POU3F2_20337985_ChIP-ChIP_501MEL_Human1.58879641
39KDM2B_26808549_Chip-Seq_REH_Human1.58704851
40PCGF2_27294783_Chip-Seq_NPCs_Mouse1.57868155
41SMAD4_21799915_ChIP-Seq_A2780_Human1.56168633
42FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.55365918
43DROSHA_22980978_ChIP-Seq_HELA_Human1.54056805
44* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.52683550
45KAP1_22055183_ChIP-Seq_ESCs_Mouse1.52486509
46AR_21572438_ChIP-Seq_LNCaP_Human1.52441226
47* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.51628814
48FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.49732594
49NFE2_27457419_Chip-Seq_LIVER_Mouse1.47753813
50* TAL1_26923725_Chip-Seq_HPCs_Mouse1.46566950
51ETV2_25802403_ChIP-Seq_MESCs_Mouse1.44486608
52* CBP_20019798_ChIP-Seq_JUKART_Human1.44234845
53* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.44234845
54ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.43457430
55MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.41876499
56RUNX2_22187159_ChIP-Seq_PCA_Human1.40302177
57ARNT_22903824_ChIP-Seq_MCF-7_Human1.40184534
58NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.40121748
59KLF5_20875108_ChIP-Seq_MESCs_Mouse1.39624762
60SOX2_22085726_ChIP-Seq_NPCs_Mouse1.39034442
61SUZ12_27294783_Chip-Seq_NPCs_Mouse1.39017305
62TCF4_23295773_ChIP-Seq_U87_Human1.38612077
63SOX2_19829295_ChIP-Seq_ESCs_Human1.34957218
64NANOG_19829295_ChIP-Seq_ESCs_Human1.34957218
65* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.34788183
66AUTS2_25519132_ChIP-Seq_293T-REX_Human1.33394636
67FLI1_21867929_ChIP-Seq_TH2_Mouse1.33291495
68ERA_21632823_ChIP-Seq_H3396_Human1.33258390
69GATA3_21867929_ChIP-Seq_CD8_Mouse1.31700856
70NR3C1_21868756_ChIP-Seq_MCF10A_Human1.30683358
71LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.30453636
72GATA3_21867929_ChIP-Seq_TH1_Mouse1.28442796
73REST_21632747_ChIP-Seq_MESCs_Mouse1.27596177
74PIAS1_25552417_ChIP-Seq_VCAP_Human1.27386250
75SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.26367912
76NANOG_20526341_ChIP-Seq_ESCs_Human1.26267864
77GATA3_21878914_ChIP-Seq_MCF-7_Human1.25815937
78MYC_19829295_ChIP-Seq_ESCs_Human1.24570418
79BCAT_22108803_ChIP-Seq_LS180_Human1.23732920
80* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.23663751
81PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.22871306
82TAF2_19829295_ChIP-Seq_ESCs_Human1.22750095
83POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.22495383
84TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22495383
85CRX_20693478_ChIP-Seq_RETINA_Mouse1.22248077
86GF1_26923725_Chip-Seq_HPCs_Mouse1.21308881
87PRDM14_20953172_ChIP-Seq_ESCs_Human1.20993589
88* SMAD3_21741376_ChIP-Seq_ESCs_Human1.20155505
89BMI1_23680149_ChIP-Seq_NPCS_Mouse1.20077616
90P53_21459846_ChIP-Seq_SAOS-2_Human1.20052936
91* NANOG_18555785_Chip-Seq_ESCs_Mouse1.19655385
92* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.18843719
93RNF2_27304074_Chip-Seq_NSC_Mouse1.18774848
94TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18040553
95EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.16860248
96OCT4_18555785_Chip-Seq_ESCs_Mouse1.16275387
97TP53_18474530_ChIP-ChIP_U2OS_Human1.15661009
98* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.15343648
99TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.15209066
100SUZ12_27294783_Chip-Seq_ESCs_Mouse1.14904745
101TCF4_22108803_ChIP-Seq_LS180_Human1.14807499
102SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.14630352
103FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.14617403
104VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.14546650
105TDRD3_21172665_ChIP-Seq_MCF-7_Human1.14480966
106RUNX1_26923725_Chip-Seq_HPCs_Mouse1.14249953
107OCT4_20526341_ChIP-Seq_ESCs_Human1.14196489
108CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.13876226
109RAC3_21632823_ChIP-Seq_H3396_Human1.13855370
110P53_22387025_ChIP-Seq_ESCs_Mouse1.13740426
111ETV1_20927104_ChIP-Seq_GIST48_Human1.13486144
112GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.13413596
113MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.13388775
114TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13312756
115CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.12999366
116CMYC_18555785_Chip-Seq_ESCs_Mouse1.12102909
117EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.11756941
118SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.11331530
119CBX2_22325352_ChIP-Seq_293T-Rex_Human1.11307308
120EZH2_27294783_Chip-Seq_NPCs_Mouse1.11188282
121RBPJ_21746931_ChIP-Seq_IB4_Human1.10317540
122FOXA1_27270436_Chip-Seq_PROSTATE_Human1.09960446
123FOXA1_25329375_ChIP-Seq_VCAP_Human1.09960446
124PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.09042381
125P300_18555785_Chip-Seq_ESCs_Mouse1.08928193
126EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.08127701
127SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.07961389
128NCOR_22424771_ChIP-Seq_293T_Human1.07680382
129OCT4_21477851_ChIP-Seq_ESCs_Mouse1.07607589
130NFYA_21822215_ChIP-Seq_K562_Human1.07476980
131CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.06248136
132EZH2_27294783_Chip-Seq_ESCs_Mouse1.06187375
133HNFA_21074721_ChIP-Seq_CACO-2_Human1.06065508
134PHF8_20622853_ChIP-Seq_HELA_Human1.06011289
135PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.05657184
136RAD21_21589869_ChIP-Seq_MESCs_Mouse1.05025703
137ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04612211
138SPI1_26923725_Chip-Seq_HPCs_Mouse1.04195834
139KLF4_18555785_Chip-Seq_ESCs_Mouse1.03905193
140CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03524490
141RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.03264617
142EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.03220269
143PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03156594
144SMAD4_21741376_ChIP-Seq_HESCs_Human1.03059126
145FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02727165
146ESRRB_18555785_Chip-Seq_ESCs_Mouse1.02650597
147ERG_20517297_ChIP-Seq_VCAP_Human1.02357723
148HOXB7_26014856_ChIP-Seq_BT474_Human1.02153631
149MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.01996094
150EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.01822927
151SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98250998
152CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.97766166
153STAT3_18555785_Chip-Seq_ESCs_Mouse0.95738368
154SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.95053994
155NFYB_21822215_ChIP-Seq_K562_Human0.94450356
156ESET_19884257_ChIP-Seq_ESCs_Mouse0.94349208
157SOX9_26525672_Chip-Seq_HEART_Mouse0.93578910
158STAT3_18555785_ChIP-Seq_MESCs_Mouse0.93225500
159GF1B_26923725_Chip-Seq_HPCs_Mouse0.92973108
160CTCF_18555785_Chip-Seq_ESCs_Mouse0.92000219
161TBL1_22424771_ChIP-Seq_293T_Human0.91109055
162KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.90466386
163SOX2_18555785_Chip-Seq_ESCs_Mouse0.90465738
164RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.90290524
165MYC_27129775_Chip-Seq_CORNEA_Mouse0.89633146
166PU1_27457419_Chip-Seq_LIVER_Mouse0.89309970
167SMAD4_21741376_ChIP-Seq_EPCs_Human0.88806815
168SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88356092
169OCT1_27270436_Chip-Seq_PROSTATE_Human0.88088939

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.12694942
2MP0001929_abnormal_gametogenesis5.43353828
3MP0008877_abnormal_DNA_methylation4.42625221
4MP0002210_abnormal_sex_determination3.42342376
5MP0002161_abnormal_fertility/fecundity3.34372766
6MP0002653_abnormal_ependyma_morphology2.95615622
7MP0001145_abnormal_male_reproductive2.88630468
8MP0005670_abnormal_white_adipose2.80428150
9MP0001348_abnormal_lacrimal_gland2.60111692
10MP0000653_abnormal_sex_gland2.50162593
11MP0003718_maternal_effect2.47546935
12MP0005623_abnormal_meninges_morphology2.19777902
13MP0005410_abnormal_fertilization16.2035422
14MP0001485_abnormal_pinna_reflex1.82930420
15MP0001486_abnormal_startle_reflex1.82218357
16MP0002138_abnormal_hepatobiliary_system1.77223584
17MP0001501_abnormal_sleep_pattern1.73881373
18MP0003195_calcinosis1.70682131
19MP0003880_abnormal_central_pattern1.59457614
20MP0009745_abnormal_behavioral_response1.58675249
21MP0002282_abnormal_trachea_morphology1.56635167
22MP0005379_endocrine/exocrine_gland_phen1.55089456
23MP0002735_abnormal_chemical_nociception1.53170571
24MP0002160_abnormal_reproductive_system1.46515226
25MP0002272_abnormal_nervous_system1.43306016
26MP0001765_abnormal_ion_homeostasis1.38652188
27MP0000678_abnormal_parathyroid_gland1.37217247
28MP0000026_abnormal_inner_ear1.35421609
29MP0002733_abnormal_thermal_nociception1.33873615
30MP0006292_abnormal_olfactory_placode1.32625868
31MP0002557_abnormal_social/conspecific_i1.31061694
32MP0003646_muscle_fatigue1.30554448
33MP0001963_abnormal_hearing_physiology1.28505010
34MP0003136_yellow_coat_color1.27019189
35MP0009046_muscle_twitch1.26409943
36MP0000049_abnormal_middle_ear1.24831588
37MP0006276_abnormal_autonomic_nervous1.24150101
38MP0005645_abnormal_hypothalamus_physiol1.23032385
39MP0002067_abnormal_sensory_capabilities1.22010735
40MP0004233_abnormal_muscle_weight1.19828460
41MP0005395_other_phenotype1.18697787
42MP0002822_catalepsy1.14938898
43MP0001970_abnormal_pain_threshold1.14360387
44MP0002837_dystrophic_cardiac_calcinosis1.13834124
45MP0008872_abnormal_physiological_respon1.12527850
46MP0004885_abnormal_endolymph1.11793096
47MP0003635_abnormal_synaptic_transmissio1.11472704
48MP0000955_abnormal_spinal_cord1.09225011
49MP0008995_early_reproductive_senescence1.09004430
50MP0003787_abnormal_imprinting1.07065601
51MP0005310_abnormal_salivary_gland1.06428004
52MP0005647_abnormal_sex_gland1.02667357
53MP0002734_abnormal_mechanical_nocicepti0.99708103
54MP0005377_hearing/vestibular/ear_phenot0.99045100
55MP0003878_abnormal_ear_physiology0.99045100
56MP0004085_abnormal_heartbeat0.98422937
57MP0000778_abnormal_nervous_system0.96755260
58MP0001984_abnormal_olfaction0.94205509
59MP0008789_abnormal_olfactory_epithelium0.92962265
60MP0002249_abnormal_larynx_morphology0.91329452
61MP0002064_seizures0.90802790
62MP0005084_abnormal_gallbladder_morpholo0.90681819
63MP0005167_abnormal_blood-brain_barrier0.89316030
64MP0002063_abnormal_learning/memory/cond0.88952537
65MP0009053_abnormal_anal_canal0.87259671
66MP0008058_abnormal_DNA_repair0.86328653
67MP0004859_abnormal_synaptic_plasticity0.85846137
68MP0002184_abnormal_innervation0.85379459
69MP0005646_abnormal_pituitary_gland0.84448632
70MP0004142_abnormal_muscle_tone0.82032907
71MP0010386_abnormal_urinary_bladder0.80461939
72MP0006072_abnormal_retinal_apoptosis0.79448533
73MP0001905_abnormal_dopamine_level0.79314254
74MP0000230_abnormal_systemic_arterial0.78235439
75MP0000372_irregular_coat_pigmentation0.77054159
76MP0003137_abnormal_impulse_conducting0.76246490
77MP0005389_reproductive_system_phenotype0.75099431
78MP0000631_abnormal_neuroendocrine_gland0.74580005
79MP0001529_abnormal_vocalization0.74390662
80MP0002132_abnormal_respiratory_system0.73590358
81MP0002752_abnormal_somatic_nervous0.73161691
82MP0003115_abnormal_respiratory_system0.72952274
83MP0005248_abnormal_Harderian_gland0.70492592
84MP0005636_abnormal_mineral_homeostasis0.69892210
85MP0004484_altered_response_of0.69856970
86MP0003252_abnormal_bile_duct0.68823417
87MP0002882_abnormal_neuron_morphology0.67615562
88MP0002638_abnormal_pupillary_reflex0.65701068
89MP0003950_abnormal_plasma_membrane0.64755978
90MP0005666_abnormal_adipose_tissue0.64490172
91MP0000569_abnormal_digit_pigmentation0.58650038
92MP0002928_abnormal_bile_duct0.53296238
93MP0003699_abnormal_female_reproductive0.52109554
94MP0001324_abnormal_eye_pigmentation0.51497267
95MP0001764_abnormal_homeostasis0.48988582
96MP0003011_delayed_dark_adaptation0.47445823
97MP0004036_abnormal_muscle_relaxation0.47078202
98MP0010094_abnormal_chromosome_stability0.46683618
99MP0001293_anophthalmia0.46682570
100MP0000358_abnormal_cell_content/0.44118399
101MP0002971_abnormal_brown_adipose0.43036395
102MP0003329_amyloid_beta_deposits0.42235958
103MP0005551_abnormal_eye_electrophysiolog0.40763227
104MP0005253_abnormal_eye_physiology0.40528110
105MP0009115_abnormal_fat_cell0.40289921
106MP0002102_abnormal_ear_morphology0.39961621
107MP0003786_premature_aging0.38089270
108MP0002269_muscular_atrophy0.37253189
109MP0001545_abnormal_hematopoietic_system0.36468314
110MP0005397_hematopoietic_system_phenotyp0.36468314
111MP0008057_abnormal_DNA_replication0.36249681
112MP0003633_abnormal_nervous_system0.34878007
113MP0009278_abnormal_bone_marrow0.34795627
114MP0002234_abnormal_pharynx_morphology0.33884401
115MP0003879_abnormal_hair_cell0.33538277
116MP0004270_analgesia0.32534168
117MP0005391_vision/eye_phenotype0.31490202
118MP0002139_abnormal_hepatobiliary_system0.30576348
119MP0001119_abnormal_female_reproductive0.30280136
120MP0008961_abnormal_basal_metabolism0.29807404
121MP0001727_abnormal_embryo_implantation0.27752551
122MP0004742_abnormal_vestibular_system0.27130652
123MP0000751_myopathy0.26592047
124MP0000534_abnormal_ureter_morphology0.26536134
125MP0002295_abnormal_pulmonary_circulatio0.25717367
126MP0002736_abnormal_nociception_after0.24719019
127MP0004019_abnormal_vitamin_homeostasis0.24623857
128MP0004811_abnormal_neuron_physiology0.24375309
129MP0003631_nervous_system_phenotype0.23983177
130MP0003942_abnormal_urinary_system0.23882051
131MP0004133_heterotaxia0.23405176
132MP0005375_adipose_tissue_phenotype0.23162095
133MP0002152_abnormal_brain_morphology0.22894014
134MP0003861_abnormal_nervous_system0.22388872
135MP0003948_abnormal_gas_homeostasis0.22073988
136MP0008007_abnormal_cellular_replicative0.21460360
137MP0006036_abnormal_mitochondrial_physio0.20909480
138MP0004130_abnormal_muscle_cell0.20637160
139MP0005423_abnormal_somatic_nervous0.20255926
140MP0003111_abnormal_nucleus_morphology0.19424084
141MP0009672_abnormal_birth_weight0.19045628
142MP0000604_amyloidosis0.18928103
143MP0002229_neurodegeneration0.17896270
144MP0008875_abnormal_xenobiotic_pharmacok0.17533349
145MP0001440_abnormal_grooming_behavior0.17263178
146MP0001968_abnormal_touch/_nociception0.16721220
147MP0003045_fibrosis0.16308746
148MP0002405_respiratory_system_inflammati0.16201759
149MP0002092_abnormal_eye_morphology0.16127215
150MP0002572_abnormal_emotion/affect_behav0.15875754
151MP0002118_abnormal_lipid_homeostasis0.15413614
152MP0001661_extended_life_span0.15267254
153MP0001730_embryonic_growth_arrest0.15204151
154MP0002169_no_abnormal_phenotype0.15195904
155MP0000920_abnormal_myelination0.15043025
156MP0002873_normal_phenotype0.14991362
157MP0004145_abnormal_muscle_electrophysio0.14768352
158MP0005365_abnormal_bile_salt0.13962192
159MP0003959_abnormal_lean_body0.13642188
160MP0008569_lethality_at_weaning0.13350736
161MP0001986_abnormal_taste_sensitivity0.13045067
162MP0005535_abnormal_body_temperature0.12598052

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.26192529
2Abnormal respiratory motile cilium morphology (HP:0005938)9.22118304
3Abnormal respiratory epithelium morphology (HP:0012253)9.22118304
4Abnormal ciliary motility (HP:0012262)7.77660438
5Rhinitis (HP:0012384)7.30963193
6Chronic bronchitis (HP:0004469)6.76859640
7Infertility (HP:0000789)6.56662132
8Nasal polyposis (HP:0100582)6.30331128
9Severe visual impairment (HP:0001141)5.58844252
10Male infertility (HP:0003251)5.30337163
11Abnormality of the nasal mucosa (HP:0000433)5.19490850
12Attenuation of retinal blood vessels (HP:0007843)5.01510192
13Chronic hepatic failure (HP:0100626)4.71802948
14Bronchitis (HP:0012387)4.58928549
15Bronchiectasis (HP:0002110)4.42235294
16Nephronophthisis (HP:0000090)4.37259299
17Bony spicule pigmentary retinopathy (HP:0007737)4.32568479
18Abnormality of macular pigmentation (HP:0008002)4.20738585
19Abnormal rod and cone electroretinograms (HP:0008323)4.01345633
20Progressive cerebellar ataxia (HP:0002073)3.95815181
21Abnormal spermatogenesis (HP:0008669)3.95071224
22Recurrent sinusitis (HP:0011108)3.67432862
23Hypoplastic ischia (HP:0003175)3.55698037
24Pancreatic cysts (HP:0001737)3.53424723
25Abnormality of the renal medulla (HP:0100957)3.31745064
26Recurrent otitis media (HP:0000403)3.30727542
27True hermaphroditism (HP:0010459)3.14322704
28Recurrent bronchitis (HP:0002837)3.13641156
29Potter facies (HP:0002009)3.10056646
30Facial shape deformation (HP:0011334)3.10056646
31Tubulointerstitial nephritis (HP:0001970)3.07125578
32Abnormality of the ischium (HP:0003174)3.06173120
33Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.04039147
34Hyperkalemia (HP:0002153)2.90605449
35Tubular atrophy (HP:0000092)2.74010602
36Molar tooth sign on MRI (HP:0002419)2.67678046
37Abnormality of midbrain morphology (HP:0002418)2.67678046
38Impulsivity (HP:0100710)2.63029740
39Enlarged epiphyses (HP:0010580)2.61992047
40Tubulointerstitial abnormality (HP:0001969)2.58622761
41Pendular nystagmus (HP:0012043)2.57204825
42Type II lissencephaly (HP:0007260)2.56689240
43Medial flaring of the eyebrow (HP:0010747)2.46695585
44Genetic anticipation (HP:0003743)2.45064195
45Optic nerve hypoplasia (HP:0000609)2.43866117
46Azoospermia (HP:0000027)2.41965354
47Retinal dysplasia (HP:0007973)2.36696360
48Aplasia/Hypoplasia of the earlobes (HP:0009906)2.34216376
49Generalized aminoaciduria (HP:0002909)2.31533410
50Gonadotropin excess (HP:0000837)2.30028121
51Atonic seizures (HP:0010819)2.29323212
52Abnormality of dental color (HP:0011073)2.28504052
53Congenital malformation of the right heart (HP:0011723)2.27664719
54Double outlet right ventricle (HP:0001719)2.27664719
55Cholecystitis (HP:0001082)2.27338868
56Abnormal gallbladder physiology (HP:0012438)2.27338868
57Genital tract atresia (HP:0001827)2.26083017
58Sclerocornea (HP:0000647)2.24994265
59Resting tremor (HP:0002322)2.23316360
60Hypophosphatemic rickets (HP:0004912)2.20308914
61Postural instability (HP:0002172)2.19694282
62Keratoconus (HP:0000563)2.18555038
63Increased corneal curvature (HP:0100692)2.18555038
64Gaze-evoked nystagmus (HP:0000640)2.15424716
65Abnormality of the hepatic vasculature (HP:0006707)2.15102080
66Portal hypertension (HP:0001409)2.14876664
67Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.14799326
68Chorioretinal atrophy (HP:0000533)2.13662676
69Abnormality of the aortic arch (HP:0012303)2.11718782
70Cone-rod dystrophy (HP:0000548)2.11326263
71Cerebellar dysplasia (HP:0007033)2.07906597
72Occipital encephalocele (HP:0002085)2.07853911
73Vaginal atresia (HP:0000148)2.07619082
74Abnormality of the pubic bones (HP:0003172)2.05941838
75Tubulointerstitial fibrosis (HP:0005576)2.05179681
76Abnormality of potassium homeostasis (HP:0011042)2.03950836
77Congenital stationary night blindness (HP:0007642)2.03944922
78Congenital sensorineural hearing impairment (HP:0008527)2.02384141
79Intestinal atresia (HP:0011100)2.00519963
80Absent/shortened dynein arms (HP:0200106)13.6870199
81Dynein arm defect of respiratory motile cilia (HP:0012255)13.6870199
82Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.9608639
83Dyschromatopsia (HP:0007641)1.99530925
84Unilateral renal agenesis (HP:0000122)1.99263102
85Anencephaly (HP:0002323)1.96597544
86Action tremor (HP:0002345)1.96596060
87Decreased central vision (HP:0007663)1.96456360
88Menstrual irregularities (HP:0000858)1.96372096
89Bulbous nose (HP:0000414)1.93001224
90Spastic tetraparesis (HP:0001285)1.92976750
91Postaxial foot polydactyly (HP:0001830)1.89649581
92Abnormal drinking behavior (HP:0030082)1.89164323
93Polydipsia (HP:0001959)1.89164323
94Macular degeneration (HP:0000608)1.88536607
95Heterotopia (HP:0002282)1.87454613
96Stage 5 chronic kidney disease (HP:0003774)1.86643502
97Amelogenesis imperfecta (HP:0000705)1.85370132
98Abnormality of the lower motor neuron (HP:0002366)1.83621583
99Congenital hepatic fibrosis (HP:0002612)1.80118628
100Gastrointestinal atresia (HP:0002589)1.79116208
101Poor coordination (HP:0002370)1.78483312
102Abnormality of the renal cortex (HP:0011035)1.77836048
103Oligodactyly (hands) (HP:0001180)1.77121803
104Abnormal biliary tract physiology (HP:0012439)1.73998263
105Bile duct proliferation (HP:0001408)1.73998263
106Short ribs (HP:0000773)1.73810709
107Absent frontal sinuses (HP:0002688)1.68888763
108Choroideremia (HP:0001139)1.68091001
109Abnormality of renal excretion (HP:0011036)1.67118221
110Microglossia (HP:0000171)1.65080497
111Oculomotor apraxia (HP:0000657)1.61771661
112Bell-shaped thorax (HP:0001591)1.60492855
113J-shaped sella turcica (HP:0002680)1.59932109
114Fibular hypoplasia (HP:0003038)1.59762801
115Asymmetric septal hypertrophy (HP:0001670)1.56279184
116Hemorrhage of the eye (HP:0011885)1.54922349
117Chronic sinusitis (HP:0011109)1.51966868
118Amyotrophic lateral sclerosis (HP:0007354)1.50099061
119Abnormality of the dental root (HP:0006486)1.48331540
120Taurodontia (HP:0000679)1.48331540
121Abnormality of permanent molar morphology (HP:0011071)1.48331540
122Hypoplasia of the capital femoral epiphysis (HP:0003090)1.47543044
123Postaxial hand polydactyly (HP:0001162)1.47174190
124Abnormality of dentin (HP:0010299)1.46048327
125Deformed sella turcica (HP:0002681)1.43931438
126Pancreatic fibrosis (HP:0100732)1.41856363
127Renal dysplasia (HP:0000110)1.40441248
128Abnormal urine output (HP:0012590)1.40048687
129Abnormality of saccadic eye movements (HP:0000570)1.39783572
130Abnormality of molar morphology (HP:0011070)1.38674924
131Abnormality of molar (HP:0011077)1.38674924
132Abnormality of the dental pulp (HP:0006479)1.37182153
133Cystic liver disease (HP:0006706)1.36088006
134Facial cleft (HP:0002006)1.35790380
135Hemiparesis (HP:0001269)1.34693936
136Aplasia/Hypoplasia of the tongue (HP:0010295)1.32568186
137Neurofibrillary tangles (HP:0002185)1.32433789
138Decreased electroretinogram (ERG) amplitude (HP:0000654)1.29708417
139Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.29612582
140Bundle branch block (HP:0011710)1.29509362
141Supernumerary spleens (HP:0009799)1.28331838
142Aplasia/Hypoplasia of the lens (HP:0008063)1.25726190
143Nephropathy (HP:0000112)1.25227696
144Gait imbalance (HP:0002141)1.24734417
145Congenital primary aphakia (HP:0007707)1.23995909
146Abnormality of ocular smooth pursuit (HP:0000617)1.23537548
147Median cleft lip (HP:0000161)1.23104794
148Short thorax (HP:0010306)1.21383587
149Impaired proprioception (HP:0010831)1.20652920
150Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.18051698
151Cerebral inclusion bodies (HP:0100314)1.17301066
152Polyuria (HP:0000103)1.17174061
153Pachygyria (HP:0001302)1.15890177
154Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.15567402
155Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.15330934
156Absent epiphyses (HP:0010577)1.15330934
157Glucose intolerance (HP:0000833)1.15216066
158Tongue fasciculations (HP:0001308)1.15057261
159Truncal obesity (HP:0001956)1.14695616

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.45844310
2PDK48.45844310
3PDK25.46966081
4TESK15.44224180
5PRKD35.41181307
6FRK4.34765893
7ICK4.09138014
8MAP4K23.91737864
9INSRR3.61009309
10DDR23.20788928
11PLK22.74132118
12PNCK2.71756070
13BMPR1B2.60383420
14PTK2B2.54411870
15WNK42.20852173
16STK392.07553928
17BRD42.06513257
18ADRBK21.75713578
19STK381.57274158
20TNIK1.44477685
21DYRK1B1.43147292
22OXSR11.41945553
23PIK3CG1.38454519
24MARK11.36857326
25AKT31.34345039
26ZAK1.33302233
27GRK11.30134428
28NEK21.24839423
29CASK1.20839132
30NTRK31.20285756
31MAPK131.15942582
32NUAK11.10323057
33PDK11.07582976
34PRKCE1.06133127
35TAF11.05693168
36TYRO31.04937820
37CDK191.03099441
38MAPK150.96901692
39WNK10.93803593
40CAMK1G0.93210810
41MKNK20.85899277
42TIE10.85757768
43DAPK20.81215215
44DYRK20.79081082
45DYRK30.72072100
46LMTK20.67889258
47MAP2K60.67498440
48ACVR1B0.66125112
49CDK30.63781824
50FER0.60889373
51VRK10.60261869
52TAOK30.60123130
53CAMK1D0.57998338
54EPHA40.57496815
55CDK70.56984402
56PDPK10.56195225
57TGFBR10.55340873
58SIK20.53269509
59PASK0.51912321
60TTK0.51568284
61CHEK20.51150696
62STK30.50884520
63IRAK10.49846260
64SGK4940.49270869
65SGK2230.49270869
66PAK30.48575531
67RIPK40.48369502
68TESK20.46683919
69SGK20.45204503
70TLK10.44414097
71TNK20.43794392
72PAK10.43528339
73CHEK10.43487294
74PRKAA20.43285945
75CDK90.42499938
76CAMK40.42230911
77CCNB10.41126977
78EEF2K0.40859802
79NEK60.39229892
80KIT0.37895541
81WEE10.37791790
82ERBB30.37136642
83NLK0.36661610
84PAK20.35405966
85TRIM280.34919738
86RPS6KA20.34178736
87ROCK10.33823684
88RPS6KA60.33302454
89STK38L0.33036100
90ADRBK10.32969758
91PRKACA0.31712665
92ATM0.30902809
93IRAK20.29898253
94MTOR0.29513857
95MST1R0.29394220
96CDK120.28389065
97PLK40.28386439
98PRKCG0.27453484
99FGFR20.27261722
100NTRK20.26647020
101CAMKK20.26143012
102CDC70.26088917
103PINK10.25488344
104UHMK10.23184269
105MARK20.22812617
106ATR0.22758205
107AKT10.21177390
108PRKAA10.19715266
109BRSK20.14782839
110RPS6KB10.14459132
111PAK40.14441212
112CSNK1D0.13094628
113CAMKK10.12379433
114MAPKAPK50.12035663
115PRKCZ0.11347153
116PRKCQ0.10610379
117MUSK0.10462618
118PLK10.10168462
119MARK30.09541091
120STK110.09513665
121PKN10.09284841
122MAP3K100.09060929
123GSK3B0.09035418
124CDK60.07747040
125RIPK10.07262373
126ZAP700.07088775
127PAK60.06601902
128CDK150.06158903
129PRKG10.05536868
130CAMK2A0.05418813
131CDK10.04746954
132CSNK2A20.04746873
133CDK20.04556189
134PRKG20.04468891
135CSNK2A10.04278599
136CDK180.03630871
137STK100.03275683
138CDK11A0.02815644
139WNK30.02708318
140RPS6KA10.02703212
141PRKDC0.02538289
142MAPK80.02241451
143PDGFRB0.02144057
144PRKCB0.02127928
145BRSK10.02109371
146PRKACG0.01634006
147MAP3K40.01068864
148MAP2K70.00804397
149CLK10.00737339
150CDK40.00645961
151CDK140.00181272
152EPHB10.00056269
153PRKCA-0.0097107
154CAMK1-0.0090894
155EGFR-0.0069537
156PRKCD-0.0068038
157MAPK1-0.0057965
158MAP3K1-0.0054014
159CSK-0.0021536

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000726.00024757
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.60876681
3Fatty acid biosynthesis_Homo sapiens_hsa000614.38315468
4Pyruvate metabolism_Homo sapiens_hsa006203.55372599
5Vitamin B6 metabolism_Homo sapiens_hsa007503.35926408
6Butanoate metabolism_Homo sapiens_hsa006503.17857316
7Olfactory transduction_Homo sapiens_hsa047403.16817973
8Propanoate metabolism_Homo sapiens_hsa006402.90778761
9Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.77806439
10Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.74890075
11Phototransduction_Homo sapiens_hsa047442.67922556
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.61890054
13Nicotine addiction_Homo sapiens_hsa050332.58607375
14Linoleic acid metabolism_Homo sapiens_hsa005912.51537217
15Glucagon signaling pathway_Homo sapiens_hsa049222.50893003
16Carbohydrate digestion and absorption_Homo sapiens_hsa049732.33336769
17Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.06711580
18Morphine addiction_Homo sapiens_hsa050322.03187544
19Basal transcription factors_Homo sapiens_hsa030222.02368287
20Glycerolipid metabolism_Homo sapiens_hsa005612.01572111
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.95159618
22PPAR signaling pathway_Homo sapiens_hsa033201.95131374
23Dorso-ventral axis formation_Homo sapiens_hsa043201.93603715
24Pentose phosphate pathway_Homo sapiens_hsa000301.86672109
25Primary bile acid biosynthesis_Homo sapiens_hsa001201.82716959
26Glycosaminoglycan degradation_Homo sapiens_hsa005311.79706461
27Selenocompound metabolism_Homo sapiens_hsa004501.76896354
28Oocyte meiosis_Homo sapiens_hsa041141.72224171
29Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.69968765
30Maturity onset diabetes of the young_Homo sapiens_hsa049501.68542595
31Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.67098285
32Glycerophospholipid metabolism_Homo sapiens_hsa005641.59374944
33Nitrogen metabolism_Homo sapiens_hsa009101.58717677
34Fructose and mannose metabolism_Homo sapiens_hsa000511.56790419
35Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.56667188
36Tryptophan metabolism_Homo sapiens_hsa003801.54415872
37Mineral absorption_Homo sapiens_hsa049781.52912516
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.51756291
39Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.50714184
40GABAergic synapse_Homo sapiens_hsa047271.50702598
41Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.48273365
42Carbon metabolism_Homo sapiens_hsa012001.45974560
43Fatty acid metabolism_Homo sapiens_hsa012121.40319469
44Fatty acid degradation_Homo sapiens_hsa000711.38154381
45Amphetamine addiction_Homo sapiens_hsa050311.36287540
46Antigen processing and presentation_Homo sapiens_hsa046121.36146971
47Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.34091715
48Fanconi anemia pathway_Homo sapiens_hsa034601.28366370
49Cardiac muscle contraction_Homo sapiens_hsa042601.25128365
50Serotonergic synapse_Homo sapiens_hsa047261.24633614
51Ether lipid metabolism_Homo sapiens_hsa005651.20928057
52Huntingtons disease_Homo sapiens_hsa050161.20457366
53mRNA surveillance pathway_Homo sapiens_hsa030151.19210556
54Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.18200470
55Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.16869171
56Renin secretion_Homo sapiens_hsa049241.16070554
57Cysteine and methionine metabolism_Homo sapiens_hsa002701.14247815
58Fat digestion and absorption_Homo sapiens_hsa049751.14207811
59Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.03764910
60Biosynthesis of amino acids_Homo sapiens_hsa012301.03084911
61Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.99706174
62RNA transport_Homo sapiens_hsa030130.96408519
63Intestinal immune network for IgA production_Homo sapiens_hsa046720.92742983
64Renin-angiotensin system_Homo sapiens_hsa046140.92424042
65Purine metabolism_Homo sapiens_hsa002300.90839595
66Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.87722936
67Insulin secretion_Homo sapiens_hsa049110.86082352
68Bile secretion_Homo sapiens_hsa049760.85938268
69Retinol metabolism_Homo sapiens_hsa008300.85039270
70Autoimmune thyroid disease_Homo sapiens_hsa053200.83566579
71Adipocytokine signaling pathway_Homo sapiens_hsa049200.80863037
72Caffeine metabolism_Homo sapiens_hsa002320.80623481
73Type I diabetes mellitus_Homo sapiens_hsa049400.79834757
74Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.78922557
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.77845368
76Thyroid hormone synthesis_Homo sapiens_hsa049180.77502707
77Arginine and proline metabolism_Homo sapiens_hsa003300.77453807
78Allograft rejection_Homo sapiens_hsa053300.77363271
79Estrogen signaling pathway_Homo sapiens_hsa049150.76802193
80Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.72834760
81Cholinergic synapse_Homo sapiens_hsa047250.71078482
82Taste transduction_Homo sapiens_hsa047420.68166942
83Long-term depression_Homo sapiens_hsa047300.65417566
84Long-term potentiation_Homo sapiens_hsa047200.64817782
85cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64058799
86Protein digestion and absorption_Homo sapiens_hsa049740.63179512
87Calcium signaling pathway_Homo sapiens_hsa040200.62792778
88Legionellosis_Homo sapiens_hsa051340.62140260
89Salivary secretion_Homo sapiens_hsa049700.61169983
90Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.60807088
91Hedgehog signaling pathway_Homo sapiens_hsa043400.60406658
92Peroxisome_Homo sapiens_hsa041460.60261767
93Glutathione metabolism_Homo sapiens_hsa004800.60185830
94Collecting duct acid secretion_Homo sapiens_hsa049660.60093159
95beta-Alanine metabolism_Homo sapiens_hsa004100.59985922
96Phenylalanine metabolism_Homo sapiens_hsa003600.59561657
97Circadian rhythm_Homo sapiens_hsa047100.59162654
98Central carbon metabolism in cancer_Homo sapiens_hsa052300.58931033
99Chemical carcinogenesis_Homo sapiens_hsa052040.58800930
100Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.58785331
101Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.57092634
102ABC transporters_Homo sapiens_hsa020100.56657967
103Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.56351166
104Pancreatic secretion_Homo sapiens_hsa049720.55440513
105Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.55120850
106Inositol phosphate metabolism_Homo sapiens_hsa005620.53571176
107Arachidonic acid metabolism_Homo sapiens_hsa005900.53124120
108Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52756790
109Gastric acid secretion_Homo sapiens_hsa049710.51392964
110Dopaminergic synapse_Homo sapiens_hsa047280.51064572
111Endocytosis_Homo sapiens_hsa041440.49876960
112Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49141315
113RNA polymerase_Homo sapiens_hsa030200.47359174
114Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46419520
115RNA degradation_Homo sapiens_hsa030180.44870850
116AMPK signaling pathway_Homo sapiens_hsa041520.43255706
117Synaptic vesicle cycle_Homo sapiens_hsa047210.42799898
118Circadian entrainment_Homo sapiens_hsa047130.41806636
119Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.40382894
120cAMP signaling pathway_Homo sapiens_hsa040240.40320165
121Homologous recombination_Homo sapiens_hsa034400.38950551
122Oxytocin signaling pathway_Homo sapiens_hsa049210.36292642
123Asthma_Homo sapiens_hsa053100.35979965
124Ovarian steroidogenesis_Homo sapiens_hsa049130.35544517
125Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34306622
126Metabolic pathways_Homo sapiens_hsa011000.34047072
127Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.32727631
128Vascular smooth muscle contraction_Homo sapiens_hsa042700.32507209
129Sulfur metabolism_Homo sapiens_hsa009200.26529846
130VEGF signaling pathway_Homo sapiens_hsa043700.20297643
131Cocaine addiction_Homo sapiens_hsa050300.20242654
132Steroid hormone biosynthesis_Homo sapiens_hsa001400.19349479
133Lysine degradation_Homo sapiens_hsa003100.17955556
134Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.16370819
135N-Glycan biosynthesis_Homo sapiens_hsa005100.14796184
136Type II diabetes mellitus_Homo sapiens_hsa049300.12127703
137Glutamatergic synapse_Homo sapiens_hsa047240.11778471
138Complement and coagulation cascades_Homo sapiens_hsa046100.09426538
139Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.07903803
140Systemic lupus erythematosus_Homo sapiens_hsa053220.07158907
141Salmonella infection_Homo sapiens_hsa051320.07136685
142Aldosterone synthesis and secretion_Homo sapiens_hsa049250.07073800
143Insulin resistance_Homo sapiens_hsa049310.05594244

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