CYLD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is encodes a cytoplasmic protein with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains that functions as a deubiquitinating enzyme. Mutations in this gene have been associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.05836479
2positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.84750115
3regulation of gamma-delta T cell activation (GO:0046643)4.78775413
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.77661593
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.74385128
6locomotory exploration behavior (GO:0035641)4.72322600
7antigen processing and presentation of endogenous antigen (GO:0019883)4.70872726
8regulation of gamma-delta T cell differentiation (GO:0045586)4.63845455
9synaptic vesicle maturation (GO:0016188)4.58367444
10positive T cell selection (GO:0043368)4.34623839
11negative regulation of T cell mediated immunity (GO:0002710)4.27821668
12regulation of short-term neuronal synaptic plasticity (GO:0048172)4.27601425
13positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.22785590
14positive thymic T cell selection (GO:0045059)4.12662148
15regulation of synapse structural plasticity (GO:0051823)4.11186269
16T cell migration (GO:0072678)4.10629496
17prepulse inhibition (GO:0060134)4.00883534
18tolerance induction (GO:0002507)3.98131311
19negative regulation of interleukin-12 production (GO:0032695)3.92131238
20leukocyte aggregation (GO:0070486)3.89704802
21T cell selection (GO:0045058)3.89231137
22modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.84465750
23modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.84465750
24positive regulation by organism of defense response of other organism involved in symbiotic interact3.84465750
25modulation by symbiont of host immune response (GO:0052553)3.84465750
26positive regulation by symbiont of host defense response (GO:0052509)3.84465750
27modulation by symbiont of host defense response (GO:0052031)3.84465750
28B cell receptor signaling pathway (GO:0050853)3.83234002
29adenosine receptor signaling pathway (GO:0001973)3.78974709
30synaptic transmission, dopaminergic (GO:0001963)3.77732118
31activated T cell proliferation (GO:0050798)3.76167941
32regulation of synaptic vesicle exocytosis (GO:2000300)3.75864565
33negative regulation of lymphocyte mediated immunity (GO:0002707)3.74499221
34regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.73627992
35regulation of long-term neuronal synaptic plasticity (GO:0048169)3.72399971
36regulation of glutamate receptor signaling pathway (GO:1900449)3.71891869
37interferon-gamma production (GO:0032609)3.67560954
38thymic T cell selection (GO:0045061)3.65406062
39negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.62163754
40negative regulation of cell killing (GO:0031342)3.62163754
41synaptic vesicle docking involved in exocytosis (GO:0016081)3.62077566
42membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.61994785
43positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.61197437
44vocalization behavior (GO:0071625)3.59058741
45ionotropic glutamate receptor signaling pathway (GO:0035235)3.57970265
46regulation of alpha-beta T cell proliferation (GO:0046640)3.55747911
47cellular extravasation (GO:0045123)3.55123576
48detection of other organism (GO:0098543)3.55059755
49positive regulation of granulocyte differentiation (GO:0030854)3.54378126
50macrophage activation involved in immune response (GO:0002281)3.53620027
51type I interferon signaling pathway (GO:0060337)3.52604036
52cellular response to type I interferon (GO:0071357)3.52604036
53response to type I interferon (GO:0034340)3.51734343
54regulation of neuronal synaptic plasticity (GO:0048168)3.51445830
55regulation of T cell tolerance induction (GO:0002664)3.50282280
56regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.48836517
57synaptic vesicle exocytosis (GO:0016079)3.47525341
58adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.44387334
59regulation of regulatory T cell differentiation (GO:0045589)3.43469303
60regulation of B cell differentiation (GO:0045577)3.40699735
61neuronal action potential propagation (GO:0019227)3.40088032
62positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.38954913
63positive regulation of B cell differentiation (GO:0045579)3.38865080
64long-term memory (GO:0007616)3.37826759
65cAMP catabolic process (GO:0006198)3.36637848
66striatum development (GO:0021756)3.36599860
67response to amphetamine (GO:0001975)3.35127351
68regulation of synaptic vesicle transport (GO:1902803)3.34120679
69detection of bacterium (GO:0016045)3.34000693
70regulation of tolerance induction (GO:0002643)3.33131743
71positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.29837185
72positive regulation of neurotransmitter transport (GO:0051590)3.28550467
73regulation of excitatory postsynaptic membrane potential (GO:0060079)3.27176987
74positive regulation of synaptic transmission, GABAergic (GO:0032230)3.26312062
75neuron-neuron synaptic transmission (GO:0007270)3.24264056
76negative regulation of leukocyte mediated immunity (GO:0002704)3.24039195
77regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.23845556
78microglial cell activation (GO:0001774)3.23159441
79interferon-gamma-mediated signaling pathway (GO:0060333)3.22506514
80G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.21456374
81transmission of nerve impulse (GO:0019226)3.21190836
82regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.20707574
83positive regulation of membrane potential (GO:0045838)3.20435295
84positive regulation of alpha-beta T cell proliferation (GO:0046641)3.19694654
85positive regulation of tolerance induction (GO:0002645)3.19573929
86response to muramyl dipeptide (GO:0032495)3.19093065
87response to peptidoglycan (GO:0032494)3.18170886
88detection of molecule of bacterial origin (GO:0032490)3.16475224
89positive regulation of neurotransmitter secretion (GO:0001956)3.14496503
90positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.14364815
91neurotransmitter secretion (GO:0007269)3.14250850
92regulation of dendritic spine morphogenesis (GO:0061001)3.13442937
93cyclic nucleotide catabolic process (GO:0009214)3.11941298
94regulation of interleukin-2 biosynthetic process (GO:0045076)3.11233790
95regulation of interferon-beta biosynthetic process (GO:0045357)3.10545247
96detection of external biotic stimulus (GO:0098581)3.09702716
97regulation of Rap GTPase activity (GO:0032317)3.09321992
98auditory behavior (GO:0031223)3.08007779
99exploration behavior (GO:0035640)3.07820612
100antigen processing and presentation via MHC class Ib (GO:0002475)3.07687320
101regulation of ARF protein signal transduction (GO:0032012)3.07420299
102defense response to protozoan (GO:0042832)3.06926640
103germinal center formation (GO:0002467)3.06765900
104regulation of T cell mediated cytotoxicity (GO:0001914)3.06439393
105dopamine receptor signaling pathway (GO:0007212)3.06039113
106antigen receptor-mediated signaling pathway (GO:0050851)3.04955386
107regulation of isotype switching to IgG isotypes (GO:0048302)3.04864961
108synaptic transmission, glutamatergic (GO:0035249)3.03816484
109negative thymic T cell selection (GO:0045060)3.03065236
110negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.02845459
111neurotransmitter-gated ion channel clustering (GO:0072578)3.02666955
112positive regulation of Rap GTPase activity (GO:0032854)3.02533109
113neutrophil activation involved in immune response (GO:0002283)3.02403389
114negative T cell selection (GO:0043383)3.01966255
115long-term synaptic potentiation (GO:0060291)3.00956438
116protein localization to synapse (GO:0035418)3.00324314
117regulation of postsynaptic membrane potential (GO:0060078)2.98705164
118regulation of natural killer cell mediated immunity (GO:0002715)2.98570930
119regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.98570930
120response to auditory stimulus (GO:0010996)2.97770337
121regulation of voltage-gated calcium channel activity (GO:1901385)2.96474823
122neuromuscular process controlling balance (GO:0050885)2.94382069
123glutamate receptor signaling pathway (GO:0007215)2.94374096
124negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.93750159
125glutamate secretion (GO:0014047)2.93558229
126negative regulation of T-helper cell differentiation (GO:0045623)2.92669201
127negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.92669201
128myeloid cell activation involved in immune response (GO:0002275)2.92261677
129T cell receptor signaling pathway (GO:0050852)2.91285306
130regulation of female receptivity (GO:0045924)2.90889533
131regulation of synaptic transmission, glutamatergic (GO:0051966)2.89602558
132regulation of synaptic plasticity (GO:0048167)2.88926677
133positive regulation of humoral immune response (GO:0002922)2.88114744
134negative regulation of adaptive immune response (GO:0002820)2.86426966
135activation of protein kinase A activity (GO:0034199)2.85680530
136visual learning (GO:0008542)2.84189309
137dendritic spine morphogenesis (GO:0060997)2.83918823
138negative regulation of erythrocyte differentiation (GO:0045647)2.83756048
139immunoglobulin mediated immune response (GO:0016064)2.83733072
140B cell homeostasis (GO:0001782)2.82817179
141positive regulation of T cell mediated cytotoxicity (GO:0001916)2.82192506
142macrophage activation (GO:0042116)2.81711107
143alpha-beta T cell differentiation (GO:0046632)2.81596660
144T cell homeostasis (GO:0043029)2.81180881
145positive regulation of interleukin-2 production (GO:0032743)2.81143729
146negative regulation of cytosolic calcium ion concentration (GO:0051481)2.80798797
147regulation of interleukin-12 biosynthetic process (GO:0045075)2.79763044
148response to host immune response (GO:0052572)2.79633558
149response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.79633558
150cellular response to interleukin-15 (GO:0071350)2.79630336
151response to protozoan (GO:0001562)2.79162234
152alpha-beta T cell activation (GO:0046631)2.78749291
153gamma-aminobutyric acid transport (GO:0015812)2.78163705
154neutrophil mediated immunity (GO:0002446)2.78157016
155regulation of B cell receptor signaling pathway (GO:0050855)2.78020799
156NIK/NF-kappaB signaling (GO:0038061)2.76397892
157detection of biotic stimulus (GO:0009595)2.75499214
158behavioral response to cocaine (GO:0048148)2.74622751
159positive regulation of isotype switching (GO:0045830)2.72545698
160T cell proliferation (GO:0042098)2.71941211
161regulation of leukocyte mediated cytotoxicity (GO:0001910)2.71104282
162response to histamine (GO:0034776)2.70095668
163vesicle transport along microtubule (GO:0047496)2.69814036
164cAMP metabolic process (GO:0046058)2.69637930
165positive regulation of gamma-delta T cell activation (GO:0046645)2.69417038
166glycine transport (GO:0015816)2.68428146
167cellular potassium ion homeostasis (GO:0030007)2.67905404
168negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.67196964
169nerve growth factor signaling pathway (GO:0038180)2.65792243
170L-amino acid import (GO:0043092)2.65048183
171response to interleukin-15 (GO:0070672)2.63999224
172mast cell activation involved in immune response (GO:0002279)2.63411145
173mast cell degranulation (GO:0043303)2.63411145
174regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.62632286
175antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.61658203
176visual behavior (GO:0007632)2.59241155
177regulation of synaptic transmission, GABAergic (GO:0032228)2.58432636
178mast cell activation (GO:0045576)2.58278262
179regulation of dendritic spine development (GO:0060998)2.57570962
180neuron cell-cell adhesion (GO:0007158)2.56368382
181regulation of neurotransmitter transport (GO:0051588)2.55592262
182membrane depolarization (GO:0051899)2.55463848
183positive regulation of synaptic transmission (GO:0050806)2.54748496
184neuronal ion channel clustering (GO:0045161)2.53914823
185regulation of glutamate secretion (GO:0014048)2.53912551
186regulation of neurotransmitter secretion (GO:0046928)2.53837915
187membrane hyperpolarization (GO:0060081)2.53328801
188substrate-independent telencephalic tangential migration (GO:0021826)2.53272118
189substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.53272118
190regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.51840753

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.72125751
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.99305720
3GBX2_23144817_ChIP-Seq_PC3_Human2.87213235
4MYB_26560356_Chip-Seq_TH2_Human2.85811135
5RARB_27405468_Chip-Seq_BRAIN_Mouse2.73739412
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.72337846
7DROSHA_22980978_ChIP-Seq_HELA_Human2.58688518
8NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.53515723
9MYB_21317192_ChIP-Seq_ERMYB_Mouse2.50313682
10MYB_26560356_Chip-Seq_TH1_Human2.28627855
11SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.26460236
12SMAD_19615063_ChIP-ChIP_OVARY_Human2.23125998
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.19476214
14VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.19247693
15STAT4_19710469_ChIP-ChIP_TH1__Mouse2.18606004
16IKZF1_21737484_ChIP-ChIP_HCT116_Human2.15836721
17JARID2_20064375_ChIP-Seq_MESCs_Mouse2.09045986
18MAF_26560356_Chip-Seq_TH1_Human2.06315295
19SCL_19346495_ChIP-Seq_HPC-7_Human2.04132310
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.00485460
21* GATA3_27048872_Chip-Seq_THYMUS_Human1.98676749
22SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.95247233
23SPI1_23547873_ChIP-Seq_NB4_Human1.92786147
24SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.92666807
25MTF2_20144788_ChIP-Seq_MESCs_Mouse1.88955034
26* REST_21632747_ChIP-Seq_MESCs_Mouse1.85761952
27RNF2_18974828_ChIP-Seq_MESCs_Mouse1.83248890
28EZH2_18974828_ChIP-Seq_MESCs_Mouse1.83248890
29* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.81790088
30RUNX_20019798_ChIP-Seq_JUKART_Human1.80188124
31E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.77605505
32SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.76645700
33RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.73583448
34IRF8_22096565_ChIP-ChIP_GC-B_Human1.72932944
35VDR_24763502_ChIP-Seq_THP-1_Human1.71070466
36EGR1_19374776_ChIP-ChIP_THP-1_Human1.70860900
37BRD4_27068464_Chip-Seq_AML-cells_Mouse1.70157864
38AR_21572438_ChIP-Seq_LNCaP_Human1.68714970
39JARID2_20075857_ChIP-Seq_MESCs_Mouse1.68341317
40* GATA3_26560356_Chip-Seq_TH2_Human1.67811745
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.66884654
42* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.66805260
43MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.63879799
44* UTX_26944678_Chip-Seq_JUKART_Human1.61252702
45RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.58761705
46SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.58754406
47SUZ12_27294783_Chip-Seq_ESCs_Mouse1.58608695
48RUNX1_22412390_ChIP-Seq_EML_Mouse1.57119701
49PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.52174590
50MYC_22102868_ChIP-Seq_BL_Human1.50183304
51IRF8_21731497_ChIP-ChIP_J774_Mouse1.49229450
52GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47943399
53EZH2_27294783_Chip-Seq_ESCs_Mouse1.46206850
54RNF2_27304074_Chip-Seq_ESCs_Mouse1.46120308
55PU_27001747_Chip-Seq_BMDM_Mouse1.43364556
56FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.42341860
57* SMAD4_21799915_ChIP-Seq_A2780_Human1.41645033
58EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41064065
59* REST_18959480_ChIP-ChIP_MESCs_Mouse1.40424888
60RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.40239276
61MAF_26560356_Chip-Seq_TH2_Human1.40097888
62KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.38533966
63TAF15_26573619_Chip-Seq_HEK293_Human1.37621569
64TCF7_22412390_ChIP-Seq_EML_Mouse1.36471299
65EZH2_27304074_Chip-Seq_ESCs_Mouse1.33556019
66TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33212872
67MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.31392986
68ZNF217_24962896_ChIP-Seq_MCF-7_Human1.28817982
69PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27057959
70NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.25975559
71FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.25219610
72IRF8_27001747_Chip-Seq_BMDM_Mouse1.25026226
73STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.25013906
74GATA2_21666600_ChIP-Seq_HMVEC_Human1.24720976
75ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.21618813
76* STAT3_23295773_ChIP-Seq_U87_Human1.21430060
77VDR_21846776_ChIP-Seq_THP-1_Human1.21269018
78SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.20893781
79CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.19903146
80LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.19439809
81CDX2_19796622_ChIP-Seq_MESCs_Mouse1.19388386
82PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17709522
83* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17459433
84ZFP57_27257070_Chip-Seq_ESCs_Mouse1.16961079
85TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.16571261
86EED_16625203_ChIP-ChIP_MESCs_Mouse1.15892698
87SPI1_23127762_ChIP-Seq_K562_Human1.15251130
88NR3C1_23031785_ChIP-Seq_PC12_Mouse1.13390909
89* P300_19829295_ChIP-Seq_ESCs_Human1.13148136
90MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.11309309
91KDM2B_26808549_Chip-Seq_SUP-B15_Human1.11079067
92* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10979380
93BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.10881037
94TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.10330402
95GATA1_19941827_ChIP-Seq_MEL_Mouse1.10066628
96* TCF4_23295773_ChIP-Seq_U87_Human1.09531076
97AHR_22903824_ChIP-Seq_MCF-7_Human1.09396106
98TP53_16413492_ChIP-PET_HCT116_Human1.09214942
99SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08600591
100SMAD3_21741376_ChIP-Seq_EPCs_Human1.08536535
101KDM2B_26808549_Chip-Seq_DND41_Human1.08221415
102RXR_22108803_ChIP-Seq_LS180_Human1.08078949
103PRDM14_20953172_ChIP-Seq_ESCs_Human1.07974120
104BP1_19119308_ChIP-ChIP_Hs578T_Human1.07886396
105AR_25329375_ChIP-Seq_VCAP_Human1.07215196
106* IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.07079235
107* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06952045
108* SOX2_21211035_ChIP-Seq_LN229_Gbm1.06705590
109GATA1_22025678_ChIP-Seq_K562_Human1.06609701
110ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.05937001
111LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.05510159
112POU3F2_20337985_ChIP-ChIP_501MEL_Human1.04927923
113AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04426273
114* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04219798
115WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03894416
116AR_19668381_ChIP-Seq_PC3_Human1.02732253
117NOTCH1_21737748_ChIP-Seq_TLL_Human1.02379973
118ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.02241841
119P53_22127205_ChIP-Seq_FIBROBLAST_Human1.02149434
120SMRT_27268052_Chip-Seq_Bcells_Human1.01738340
121CTBP2_25329375_ChIP-Seq_LNCAP_Human1.01155576
122* GATA1_19941826_ChIP-Seq_K562_Human1.00482060
123GATA2_22383799_ChIP-Seq_G1ME_Mouse1.00153261
124ARNT_22903824_ChIP-Seq_MCF-7_Human0.99636678
125IGF1R_20145208_ChIP-Seq_DFB_Human0.99291948
126IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.99205950
127KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.98814375
128TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97974854
129DNAJC2_21179169_ChIP-ChIP_NT2_Human0.96964606
130CTNNB1_20460455_ChIP-Seq_HCT116_Human0.96953258
131* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96387397
132CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.96309195
133GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.95958899
134CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95749159
135NANOG_18555785_Chip-Seq_ESCs_Mouse0.95272996
136VDR_24787735_ChIP-Seq_THP-1_Human0.94905432
137PIAS1_25552417_ChIP-Seq_VCAP_Human0.94278672
138CTBP1_25329375_ChIP-Seq_LNCAP_Human0.94041253
139ESR1_20079471_ChIP-ChIP_T-47D_Human0.92773451
140Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.92444002
141SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91499929
142SMAD3_21741376_ChIP-Seq_HESCs_Human0.90918779
143RUNX2_22187159_ChIP-Seq_PCA_Human0.90626569
144CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89948493
145FLI1_27457419_Chip-Seq_LIVER_Mouse0.89801025
146KDM2B_26808549_Chip-Seq_JURKAT_Human0.88500595
147NR3C1_21868756_ChIP-Seq_MCF10A_Human0.88313394
148TP53_18474530_ChIP-ChIP_U2OS_Human0.87255898
149SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.86969110
150STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.86459834
151* GATA2_19941826_ChIP-Seq_K562_Human0.85912720
152E2F1_18555785_Chip-Seq_ESCs_Mouse0.85872154
153NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.85250944
154P53_22387025_ChIP-Seq_ESCs_Mouse0.84968063
155FOXO3_23340844_ChIP-Seq_DLD1_Human0.84557359
156ELF1_17652178_ChIP-ChIP_JURKAT_Human0.84079380
157GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.81717380
158CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81410545
159VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.80106316
160CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.79100267
161GATA3_26560356_Chip-Seq_TH1_Human0.78883724
162BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.75043256
163FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.73813129
164GATA1_19941827_ChIP-Seq_MEL86_Mouse0.72788653
165PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.72329009
166PCGF2_27294783_Chip-Seq_NPCs_Mouse0.71036709
167PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.70947303
168PCGF2_27294783_Chip-Seq_ESCs_Mouse0.67879007
169* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.66962405
170OCT4_21477851_ChIP-Seq_ESCs_Mouse0.66382267
171EZH2_27294783_Chip-Seq_NPCs_Mouse0.65165654
172KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.64618093
173GATA1_22383799_ChIP-Seq_G1ME_Mouse0.64600940
174CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.64108252
175SUZ12_27294783_Chip-Seq_NPCs_Mouse0.62751374

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy5.84149168
2MP0004859_abnormal_synaptic_plasticity5.43631775
3MP0003880_abnormal_central_pattern3.73614096
4MP0003724_increased_susceptibility_to3.58225682
5MP0003635_abnormal_synaptic_transmissio3.41983988
6MP0009745_abnormal_behavioral_response3.19496997
7MP0002063_abnormal_learning/memory/cond2.72854325
8MP0004270_analgesia2.69353331
9MP0002064_seizures2.66356717
10MP0009046_muscle_twitch2.49507854
11MP0001486_abnormal_startle_reflex2.30042659
12MP0002572_abnormal_emotion/affect_behav2.28526661
13MP0002272_abnormal_nervous_system2.20083647
14MP0001968_abnormal_touch/_nociception2.11760637
15MP0001501_abnormal_sleep_pattern2.10088669
16MP0000569_abnormal_digit_pigmentation2.09915976
17MP0002405_respiratory_system_inflammati2.08391702
18MP0009333_abnormal_splenocyte_physiolog2.06977085
19MP0005423_abnormal_somatic_nervous2.01619233
20MP0002909_abnormal_adrenal_gland1.98103898
21MP0008569_lethality_at_weaning1.94092367
22MP0004947_skin_inflammation1.92303437
23MP0001835_abnormal_antigen_presentation1.91073739
24MP0004510_myositis1.89126094
25* MP0010155_abnormal_intestine_physiology1.82013521
26MP0005671_abnormal_response_to1.80020911
27* MP0000703_abnormal_thymus_morphology1.79354938
28MP0005409_darkened_coat_color1.77891360
29* MP0000689_abnormal_spleen_morphology1.73301068
30* MP0001845_abnormal_inflammatory_respons1.72353403
31MP0002734_abnormal_mechanical_nocicepti1.70154597
32MP0003303_peritoneal_inflammation1.67185691
33* MP0002722_abnormal_immune_system1.66826399
34MP0009780_abnormal_chondrocyte_physiolo1.64055396
35MP0001533_abnormal_skeleton_physiology1.61545453
36MP0003075_altered_response_to1.59963405
37MP0004381_abnormal_hair_follicle1.59801878
38MP0003787_abnormal_imprinting1.58222111
39MP0005646_abnormal_pituitary_gland1.57600903
40MP0004924_abnormal_behavior1.54590342
41MP0005386_behavior/neurological_phenoty1.54590342
42* MP0002429_abnormal_blood_cell1.52500557
43MP0001970_abnormal_pain_threshold1.50570631
44MP0000920_abnormal_myelination1.50357430
45MP0005310_abnormal_salivary_gland1.50326312
46MP0005387_immune_system_phenotype1.49883321
47MP0001790_abnormal_immune_system1.49883321
48MP0008057_abnormal_DNA_replication1.47968101
49MP0003633_abnormal_nervous_system1.47150865
50MP0005000_abnormal_immune_tolerance1.46845831
51MP0003172_abnormal_lysosome_physiology1.41737289
52MP0001873_stomach_inflammation1.41071841
53MP0001851_eye_inflammation1.41048470
54MP0008260_abnormal_autophagy1.38174518
55MP0008874_decreased_physiological_sensi1.37552175
56MP0000013_abnormal_adipose_tissue1.37197824
57MP0003045_fibrosis1.36419096
58MP0002138_abnormal_hepatobiliary_system1.36007651
59MP0005645_abnormal_hypothalamus_physiol1.35840907
60MP0003690_abnormal_glial_cell1.34338633
61MP0000465_gastrointestinal_hemorrhage1.33058314
62MP0005451_abnormal_body_composition1.33019683
63MP0004811_abnormal_neuron_physiology1.32908570
64MP0002067_abnormal_sensory_capabilities1.31476285
65MP0003828_pulmonary_edema1.31191461
66MP0002396_abnormal_hematopoietic_system1.30609922
67MP0002733_abnormal_thermal_nociception1.29862009
68MP0001440_abnormal_grooming_behavior1.29089037
69MP0002009_preneoplasia1.29071645
70MP0002736_abnormal_nociception_after1.27751388
71MP0001188_hyperpigmentation1.27453533
72MP0009764_decreased_sensitivity_to1.26939606
73MP0001853_heart_inflammation1.26474222
74MP0002557_abnormal_social/conspecific_i1.25877677
75MP0003866_abnormal_defecation1.25185043
76* MP0008469_abnormal_protein_level1.23859855
77MP0002998_abnormal_bone_remodeling1.22869254
78* MP0001800_abnormal_humoral_immune1.22396913
79MP0001529_abnormal_vocalization1.20190395
80MP0000685_abnormal_immune_system1.19306729
81* MP0002723_abnormal_immune_serum1.16951850
82MP0003656_abnormal_erythrocyte_physiolo1.16235591
83MP0002735_abnormal_chemical_nociception1.16197450
84MP0001502_abnormal_circadian_rhythm1.15239955
85* MP0002420_abnormal_adaptive_immunity1.14465891
86MP0004883_abnormal_blood_vessel1.14160174
87MP0002166_altered_tumor_susceptibility1.13556544
88MP0003879_abnormal_hair_cell1.13418509
89MP0005167_abnormal_blood-brain_barrier1.13282925
90MP0003763_abnormal_thymus_physiology1.12936819
91* MP0001819_abnormal_immune_cell1.12739780
92MP0001984_abnormal_olfaction1.12684315
93MP0005075_abnormal_melanosome_morpholog1.10460233
94* MP0002452_abnormal_antigen_presenting1.09793081
95MP0005464_abnormal_platelet_physiology1.09545148
96MP0003191_abnormal_cellular_cholesterol1.09418593
97MP0002419_abnormal_innate_immunity1.08782646
98MP0002148_abnormal_hypersensitivity_rea1.08659405
99MP0004808_abnormal_hematopoietic_stem1.08524370
100MP0010234_abnormal_vibrissa_follicle1.07212623
101MP0003631_nervous_system_phenotype1.05032459
102MP0000858_altered_metastatic_potential1.04900565
103MP0003448_altered_tumor_morphology1.02903954
104MP0003183_abnormal_peptide_metabolism1.02838141
105MP0002006_tumorigenesis1.02405598
106MP0003329_amyloid_beta_deposits1.00465902
107MP0008872_abnormal_physiological_respon0.98867062
108MP0005535_abnormal_body_temperature0.98079236
109* MP0002066_abnormal_motor_capabilities/c0.97906644
110MP0008961_abnormal_basal_metabolism0.95478558
111MP0002933_joint_inflammation0.93868049
112MP0000015_abnormal_ear_pigmentation0.93245977
113MP0004885_abnormal_endolymph0.91656431
114MP0001905_abnormal_dopamine_level0.90529809
115MP0005164_abnormal_response_to0.88647608
116* MP0005025_abnormal_response_to0.88616228
117MP0002332_abnormal_exercise_endurance0.88489654
118MP0002277_abnormal_respiratory_mucosa0.88199346
119MP0004742_abnormal_vestibular_system0.86038065
120MP0005166_decreased_susceptibility_to0.85478014
121MP0005397_hematopoietic_system_phenotyp0.85322451
122MP0001545_abnormal_hematopoietic_system0.85322451
123MP0000604_amyloidosis0.84131317
124MP0005174_abnormal_tail_pigmentation0.83910859
125* MP0000716_abnormal_immune_system0.82458488
126MP0009763_increased_sensitivity_to0.82348344
127MP0009278_abnormal_bone_marrow0.81617129
128* MP0003091_abnormal_cell_migration0.81145962
129MP0003436_decreased_susceptibility_to0.80603348
130* MP0002398_abnormal_bone_marrow0.80151689
131* MP0009785_altered_susceptibility_to0.79836351
132MP0004130_abnormal_muscle_cell0.79581852
133MP0000955_abnormal_spinal_cord0.79024652
134MP0005058_abnormal_lysosome_morphology0.77903121
135MP0002882_abnormal_neuron_morphology0.77641019
136MP0002229_neurodegeneration0.77204108
137MP0002184_abnormal_innervation0.77012538
138MP0001663_abnormal_digestive_system0.76395904
139MP0003221_abnormal_cardiomyocyte_apopto0.74366013
140MP0002693_abnormal_pancreas_physiology0.74055776
141* MP0003300_gastrointestinal_ulcer0.73781336
142MP0010386_abnormal_urinary_bladder0.73625079
143MP0008004_abnormal_stomach_pH0.72909579
144MP0002090_abnormal_vision0.71515813
145MP0006082_CNS_inflammation0.71011768
146MP0001765_abnormal_ion_homeostasis0.70136162
147MP0002877_abnormal_melanocyte_morpholog0.69768028
148MP0000249_abnormal_blood_vessel0.67274101
149MP0004484_altered_response_of0.66404631
150MP0009765_abnormal_xenobiotic_induced0.64960568
151MP0009115_abnormal_fat_cell0.60845769
152MP0002132_abnormal_respiratory_system0.59980522
153MP0003795_abnormal_bone_structure0.56580578
154MP0003252_abnormal_bile_duct0.54023312
155MP0001986_abnormal_taste_sensitivity0.53528416
156MP0005390_skeleton_phenotype0.52773286

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.33675558
2Myokymia (HP:0002411)5.93338898
3Focal seizures (HP:0007359)4.81549271
4Elevated erythrocyte sedimentation rate (HP:0003565)4.56317206
5Visual hallucinations (HP:0002367)4.38276996
6Orchitis (HP:0100796)4.37097935
7Papilledema (HP:0001085)4.00465134
8Abnormality of T cells (HP:0002843)3.77122254
9Febrile seizures (HP:0002373)3.71387052
10Gastrointestinal infarctions (HP:0005244)3.68152762
11Abnormality of macrophages (HP:0004311)3.67429220
12Vasculitis (HP:0002633)3.58437488
13Autoimmune hemolytic anemia (HP:0001890)3.43604375
14Action tremor (HP:0002345)3.40847655
15Keratoconjunctivitis sicca (HP:0001097)3.39313372
16Gaze-evoked nystagmus (HP:0000640)3.31253161
17Encephalitis (HP:0002383)3.25830478
18Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.21968966
19Spontaneous hematomas (HP:0007420)3.19129524
20Atonic seizures (HP:0010819)3.18380145
21Keratoconjunctivitis (HP:0001096)3.17334090
22Pustule (HP:0200039)3.12810947
23Resting tremor (HP:0002322)3.10121360
24Dialeptic seizures (HP:0011146)3.09729643
25Leukocytosis (HP:0001974)3.08789576
26Epileptic encephalopathy (HP:0200134)3.07982325
27Poor eye contact (HP:0000817)3.07419743
28Recurrent gram-negative bacterial infections (HP:0005420)3.02156104
29Progressive cerebellar ataxia (HP:0002073)3.01803975
30Impaired vibration sensation in the lower limbs (HP:0002166)3.01176410
31Absence seizures (HP:0002121)2.99490699
32Broad-based gait (HP:0002136)2.99060140
33Scanning speech (HP:0002168)2.96160353
34Hemoptysis (HP:0002105)2.93948415
35Gingivitis (HP:0000230)2.91916970
36Urinary bladder sphincter dysfunction (HP:0002839)2.86295639
37Chest pain (HP:0100749)2.84594392
38Truncal ataxia (HP:0002078)2.83860630
39Dysmetria (HP:0001310)2.82937545
40Depression (HP:0000716)2.79672325
41Arterial thrombosis (HP:0004420)2.78377666
42Abnormality of T cell physiology (HP:0011840)2.77055877
43Anxiety (HP:0000739)2.77003112
44Dysdiadochokinesis (HP:0002075)2.76807630
45Eosinophilia (HP:0001880)2.76505687
46Annular pancreas (HP:0001734)2.74677978
47Abnormality of eosinophils (HP:0001879)2.73164284
48Ankle clonus (HP:0011448)2.73024276
49IgG deficiency (HP:0004315)2.72650184
50Abnormal social behavior (HP:0012433)2.71858355
51Impaired social interactions (HP:0000735)2.71858355
52Impaired smooth pursuit (HP:0007772)2.71217119
53Generalized tonic-clonic seizures (HP:0002069)2.67902925
54Granulocytopenia (HP:0001913)2.66432779
55Stereotypic behavior (HP:0000733)2.65819172
56Increased IgM level (HP:0003496)2.65464373
57Stomatitis (HP:0010280)2.65094939
58Chronic otitis media (HP:0000389)2.60210242
59Lymphopenia (HP:0001888)2.57519764
60Gingival bleeding (HP:0000225)2.53458088
61Ocular albinism (HP:0001107)2.53063484
62T lymphocytopenia (HP:0005403)2.51517470
63Abnormal delayed hypersensitivity skin test (HP:0002963)2.51504602
64Postural instability (HP:0002172)2.51146163
65Severe combined immunodeficiency (HP:0004430)2.50657531
66Chronic mucocutaneous candidiasis (HP:0002728)2.49236028
67Recurrent cutaneous fungal infections (HP:0011370)2.49236028
68Urticaria (HP:0001025)2.48664184
69Supranuclear gaze palsy (HP:0000605)2.48140808
70Pulmonary embolism (HP:0002204)2.47086258
71Abnormality of T cell number (HP:0011839)2.45988362
72Abnormality of cells of the lymphoid lineage (HP:0012140)2.44626984
73Prolonged bleeding time (HP:0003010)2.44459778
74Eczematoid dermatitis (HP:0000976)2.44127578
75Torticollis (HP:0000473)2.41513161
76Intention tremor (HP:0002080)2.41469746
77Lower limb amyotrophy (HP:0007210)2.41121680
78Hematochezia (HP:0002573)2.40458627
79Autoimmune thrombocytopenia (HP:0001973)2.40326387
80Urinary urgency (HP:0000012)2.36428479
81Epistaxis (HP:0000421)2.35419309
82Abnormality of oral frenula (HP:0000190)2.35150952
83Dysmetric saccades (HP:0000641)2.34480808
84Recurrent fungal infections (HP:0002841)2.33922084
85Optic neuritis (HP:0100653)2.33432226
86Retrobulbar optic neuritis (HP:0100654)2.33432226
87Spastic gait (HP:0002064)2.33153337
88IgM deficiency (HP:0002850)2.32256432
89Genetic anticipation (HP:0003743)2.32108407
90Acute hepatic failure (HP:0006554)2.29520865
91Papilloma (HP:0012740)2.29501327
92Verrucae (HP:0200043)2.29501327
93Agammaglobulinemia (HP:0004432)2.28357934
94Gangrene (HP:0100758)2.27968129
95Iris hypopigmentation (HP:0007730)2.27760079
96Abnormal eating behavior (HP:0100738)2.27009050
97Recurrent abscess formation (HP:0002722)2.26728891
98Joint swelling (HP:0001386)2.26377449
99Neoplasm of the tracheobronchial system (HP:0100552)2.25410802
100Abnormality of ocular smooth pursuit (HP:0000617)2.25096401
101Generalized hypopigmentation of hair (HP:0011358)2.24914492
102Progressive inability to walk (HP:0002505)2.24505992
103IgA deficiency (HP:0002720)2.21856335
104Recurrent viral infections (HP:0004429)2.21737334
105Cellulitis (HP:0100658)2.20524423
106Frequent falls (HP:0002359)2.18963576
107Hemiplegia (HP:0002301)2.18125005
108Onion bulb formation (HP:0003383)2.17699683
109Axonal loss (HP:0003447)2.17461326
110Stomach cancer (HP:0012126)2.17066112
111Ankyloglossia (HP:0010296)2.16968924
112Hypergammaglobulinemia (HP:0010702)2.15558049
113Peripheral hypomyelination (HP:0007182)2.14319258
114Abnormality of saccadic eye movements (HP:0000570)2.13764851
115Gastrointestinal stroma tumor (HP:0100723)2.13311371
116Abnormality of binocular vision (HP:0011514)2.12864540
117Diplopia (HP:0000651)2.12864540
118Viral hepatitis (HP:0006562)2.11508529
119Fatigue (HP:0012378)2.08191855
120Anorexia (HP:0002039)2.07915562
121Spinal canal stenosis (HP:0003416)2.07779518
122Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.07485931
123Abnormality of the pleura (HP:0002103)2.07143931
124Abnormality of the fingertips (HP:0001211)2.07013361
125Osteomyelitis (HP:0002754)2.06629475
126Episodic fever (HP:0001954)2.06321938
127Impaired vibratory sensation (HP:0002495)2.05866296
128Focal dystonia (HP:0004373)2.05791370
129Alveolar cell carcinoma (HP:0006519)2.05069989
130Hypochromic anemia (HP:0001931)2.02989439
131Absent frontal sinuses (HP:0002688)2.02289715
132Pointed chin (HP:0000307)2.02025470
133Hypochromic microcytic anemia (HP:0004840)2.01369946
134Pulmonary infiltrates (HP:0002113)1.99346864
135Mediastinal lymphadenopathy (HP:0100721)1.99344244
136Myositis (HP:0100614)1.99311232
137Distal lower limb amyotrophy (HP:0008944)1.99149000
138Macroorchidism (HP:0000053)1.98814298
139Recurrent bacterial skin infections (HP:0005406)1.98583482
140Inflammation of the large intestine (HP:0002037)1.98292022
141Subacute progressive viral hepatitis (HP:0006572)1.97464079
142Meningitis (HP:0001287)1.94210941
143Keratitis (HP:0000491)1.93940132
144Bradykinesia (HP:0002067)1.92479675
145Craniofacial dystonia (HP:0012179)1.91470751
146Increased IgE level (HP:0003212)1.90871767
147Thyroiditis (HP:0100646)1.90427813
148Abnormality of B cell number (HP:0010975)1.90071926
149Abnormality of the periventricular white matter (HP:0002518)1.89447584
150Combined immunodeficiency (HP:0005387)1.88644509
151Peritonitis (HP:0002586)1.87942426
152Chronic diarrhea (HP:0002028)1.87558786
153Panhypogammaglobulinemia (HP:0003139)1.87324014
154Inappropriate behavior (HP:0000719)1.86481611
155Chronic obstructive pulmonary disease (HP:0006510)1.84610343
156Obstructive lung disease (HP:0006536)1.84610343
157Slow saccadic eye movements (HP:0000514)1.84434212
158Microcytic anemia (HP:0001935)1.84207014
159Increased CSF protein (HP:0002922)1.83734561
160Sepsis (HP:0100806)1.82856357
161Glomerulopathy (HP:0100820)1.82852236
162Abnormality of the endocardium (HP:0004306)1.82813735
163Hypoplasia of the thymus (HP:0000778)1.82207395
164Gastrointestinal inflammation (HP:0004386)1.80128953
165Blue irides (HP:0000635)1.80055203
166Recurrent skin infections (HP:0001581)1.79931875
167Colitis (HP:0002583)1.79725221
168Recurrent bronchitis (HP:0002837)1.77486107

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.16013574
2NTRK33.77834051
3RIPK43.57562755
4MAP3K133.15574104
5MAP3K92.64517492
6TNIK2.55587043
7BLK2.46051608
8FES2.36778329
9TAOK32.22670165
10DAPK22.15515498
11CAMKK12.10179678
12CSK2.01419496
13KSR21.87135413
14TXK1.85725684
15BMPR21.75075882
16MAP2K31.74826381
17CAMKK21.74331026
18GRK61.68936429
19MAP3K141.68092721
20JAK11.56760116
21MINK11.56303745
22MAP3K21.54883663
23MAP4K11.52773045
24NLK1.50822029
25PRKCH1.48536843
26SIK21.46861161
27MAP3K121.39382724
28MAP3K41.36926002
29PRPF4B1.35618698
30SIK31.33365539
31NTRK11.31879820
32FGFR41.31363527
33NTRK21.30464348
34TNK21.29939755
35CDK51.27816690
36RIPK11.26712550
37IRAK11.22866536
38SGK21.22363553
39PRKD31.21750415
40FGFR31.19625103
41MARK31.19486362
42SGK31.19332837
43MAP2K71.17777216
44* IKBKB1.17113981
45PAK61.16325968
46DAPK11.14074850
47FGR1.12977763
48ITK1.08634624
49NEK61.07237405
50CDK121.03176553
51HCK1.02972624
52PDK11.00920281
53SGK2230.99430431
54SGK4940.99430431
55EPHB10.96462413
56MAP3K30.96203630
57STK380.94290003
58SYK0.93029025
59TAOK10.91584061
60IRAK20.91129148
61IRAK40.90599823
62PRKCQ0.90082830
63MAP3K10.89717374
64SGK10.89271151
65STK110.87871503
66KSR10.87678330
67JAK30.87255801
68MAP2K40.86942977
69YES10.85929185
70FRK0.85364043
71CHUK0.84903667
72CSF1R0.84091665
73RET0.83137797
74BRD40.81191878
75NEK90.81129275
76RAF10.80328944
77TEC0.78204071
78CAMK10.77756073
79PDPK10.77569866
80WNK10.77032835
81PIM10.76677345
82EPHA30.76260053
83FYN0.75819322
84TRPM70.75185512
85MARK20.73762700
86MAPK120.73662403
87TGFBR20.73305182
88TYK20.73299497
89CAMK2B0.72614582
90IRAK30.72613767
91HIPK20.71234466
92ARAF0.70355972
93FGFR20.70095827
94STK100.68701641
95MARK10.66248468
96* IKBKE0.65703456
97PASK0.64854369
98PIK3CG0.64802891
99ERN10.64501085
100MAP3K70.63991529
101JAK20.62972183
102LCK0.62852304
103ALK0.61515229
104UHMK10.61203148
105CDK190.60247852
106MATK0.59418839
107CAMK2A0.58768377
108PRKD20.58673282
109ZAP700.58039345
110GRK70.57848062
111TYRO30.57060511
112CDC42BPA0.56899005
113TAOK20.55582442
114CDK60.55298521
115CAMK40.54935540
116MAP3K50.54565851
117DMPK0.53450130
118MAPK110.50162060
119MAP3K60.50060343
120GRK50.49834953
121PTK2B0.49279367
122MAP2K60.48966134
123MAP3K100.48636636
124OXSR10.47492310
125PRKCG0.46849347
126TBK10.46027638
127MAP3K110.43508995
128MELK0.43370864
129PDGFRB0.42892790
130RPS6KA30.41159068
131PINK10.39914511
132KIT0.39478891
133STK240.38485894
134CLK10.38440159
135LYN0.38049498
136CDK40.38015392
137MAPK130.37998359
138PLK20.37436228
139MAPK70.36742652
140BTK0.36311341
141PRKCE0.36001439
142SCYL20.35906152
143PRKCB0.35714856
144CDK180.35628217
145EGFR0.35385958
146MAPK100.35108697

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047402.76388661
2Autoimmune thyroid disease_Homo sapiens_hsa053202.44933588
3Morphine addiction_Homo sapiens_hsa050322.38040887
4Long-term potentiation_Homo sapiens_hsa047202.27198179
5Nicotine addiction_Homo sapiens_hsa050332.24881298
6Circadian entrainment_Homo sapiens_hsa047132.19298284
7Amphetamine addiction_Homo sapiens_hsa050312.15112267
8GABAergic synapse_Homo sapiens_hsa047272.04581540
9Glutamatergic synapse_Homo sapiens_hsa047241.99511875
10Synaptic vesicle cycle_Homo sapiens_hsa047211.97103646
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.95100027
12Cocaine addiction_Homo sapiens_hsa050301.85670144
13Cholinergic synapse_Homo sapiens_hsa047251.84862318
14Dopaminergic synapse_Homo sapiens_hsa047281.81729870
15Staphylococcus aureus infection_Homo sapiens_hsa051501.80158018
16Salivary secretion_Homo sapiens_hsa049701.73096324
17* RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.69407630
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.67105433
19Asthma_Homo sapiens_hsa053101.63048843
20Gastric acid secretion_Homo sapiens_hsa049711.61574957
21Renin secretion_Homo sapiens_hsa049241.59734313
22Hematopoietic cell lineage_Homo sapiens_hsa046401.59499055
23Jak-STAT signaling pathway_Homo sapiens_hsa046301.59177301
24Antigen processing and presentation_Homo sapiens_hsa046121.54246142
25Influenza A_Homo sapiens_hsa051641.54063104
26Phosphatidylinositol signaling system_Homo sapiens_hsa040701.52576347
27Insulin secretion_Homo sapiens_hsa049111.51647305
28Toxoplasmosis_Homo sapiens_hsa051451.51466065
29Acute myeloid leukemia_Homo sapiens_hsa052211.47279370
30Oxytocin signaling pathway_Homo sapiens_hsa049211.44837951
31Viral myocarditis_Homo sapiens_hsa054161.39447638
32Calcium signaling pathway_Homo sapiens_hsa040201.36420769
33Herpes simplex infection_Homo sapiens_hsa051681.35755137
34Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.32773349
35Hepatitis B_Homo sapiens_hsa051611.31819704
36Serotonergic synapse_Homo sapiens_hsa047261.30409317
37Malaria_Homo sapiens_hsa051441.30287086
38Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.29861696
39Type II diabetes mellitus_Homo sapiens_hsa049301.28755146
40T cell receptor signaling pathway_Homo sapiens_hsa046601.28374222
41Long-term depression_Homo sapiens_hsa047301.27213310
42Chemokine signaling pathway_Homo sapiens_hsa040621.27120764
43Primary immunodeficiency_Homo sapiens_hsa053401.26506700
44Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.26023472
45Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.25257748
46Legionellosis_Homo sapiens_hsa051341.25063669
47GnRH signaling pathway_Homo sapiens_hsa049121.23639318
48B cell receptor signaling pathway_Homo sapiens_hsa046621.22615278
49Type I diabetes mellitus_Homo sapiens_hsa049401.22246955
50cAMP signaling pathway_Homo sapiens_hsa040241.21929356
51Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.19899371
52Hepatitis C_Homo sapiens_hsa051601.13806590
53Taste transduction_Homo sapiens_hsa047421.10729506
54Glioma_Homo sapiens_hsa052141.09341836
55* Osteoclast differentiation_Homo sapiens_hsa043801.06879588
56Pancreatic cancer_Homo sapiens_hsa052120.97921753
57AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.97324258
58Gap junction_Homo sapiens_hsa045400.96555033
59Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.95200103
60Apoptosis_Homo sapiens_hsa042100.94992612
61Estrogen signaling pathway_Homo sapiens_hsa049150.94511555
62Leishmaniasis_Homo sapiens_hsa051400.94118317
63Pertussis_Homo sapiens_hsa051330.93302453
64Phospholipase D signaling pathway_Homo sapiens_hsa040720.93286532
65FoxO signaling pathway_Homo sapiens_hsa040680.92705632
66Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.91451440
67Dorso-ventral axis formation_Homo sapiens_hsa043200.90040249
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.89279575
69cGMP-PKG signaling pathway_Homo sapiens_hsa040220.89186333
70Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.87557349
71Platelet activation_Homo sapiens_hsa046110.87271361
72ErbB signaling pathway_Homo sapiens_hsa040120.85776188
73Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.85325055
74Inositol phosphate metabolism_Homo sapiens_hsa005620.83586089
75Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83348322
76Non-small cell lung cancer_Homo sapiens_hsa052230.82863402
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.81761105
78MAPK signaling pathway_Homo sapiens_hsa040100.81488053
79Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.79235735
80Toll-like receptor signaling pathway_Homo sapiens_hsa046200.78814540
81Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.78585201
82VEGF signaling pathway_Homo sapiens_hsa043700.78453311
83Pancreatic secretion_Homo sapiens_hsa049720.77919104
84Choline metabolism in cancer_Homo sapiens_hsa052310.77208346
85Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.76687736
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75782784
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.75573923
88Phagosome_Homo sapiens_hsa041450.74707536
89Tuberculosis_Homo sapiens_hsa051520.74638028
90Sphingolipid signaling pathway_Homo sapiens_hsa040710.73271089
91Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.72774803
92Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72263470
93Epstein-Barr virus infection_Homo sapiens_hsa051690.70954428
94Thyroid hormone synthesis_Homo sapiens_hsa049180.70075033
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69435072
96Endometrial cancer_Homo sapiens_hsa052130.68229070
97Prolactin signaling pathway_Homo sapiens_hsa049170.68157128
98Other glycan degradation_Homo sapiens_hsa005110.67952507
99Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.67081347
100Rap1 signaling pathway_Homo sapiens_hsa040150.66760384
101Shigellosis_Homo sapiens_hsa051310.65984998
102Intestinal immune network for IgA production_Homo sapiens_hsa046720.65613934
103Endocytosis_Homo sapiens_hsa041440.64229703
104NF-kappa B signaling pathway_Homo sapiens_hsa040640.64097823
105Allograft rejection_Homo sapiens_hsa053300.63618161
106African trypanosomiasis_Homo sapiens_hsa051430.63226967
107TNF signaling pathway_Homo sapiens_hsa046680.62991676
108Viral carcinogenesis_Homo sapiens_hsa052030.61944161
109Prostate cancer_Homo sapiens_hsa052150.61574863
110Collecting duct acid secretion_Homo sapiens_hsa049660.61382441
111Phototransduction_Homo sapiens_hsa047440.60877520
112Ras signaling pathway_Homo sapiens_hsa040140.60272983
113Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.59974334
114Melanogenesis_Homo sapiens_hsa049160.59794567
115HTLV-I infection_Homo sapiens_hsa051660.59484166
116Insulin resistance_Homo sapiens_hsa049310.58909518
117Measles_Homo sapiens_hsa051620.58151910
118Adipocytokine signaling pathway_Homo sapiens_hsa049200.57795020
119Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57586218
120Salmonella infection_Homo sapiens_hsa051320.57544397
121Rheumatoid arthritis_Homo sapiens_hsa053230.57291701
122Colorectal cancer_Homo sapiens_hsa052100.56214999
123NOD-like receptor signaling pathway_Homo sapiens_hsa046210.55553411
124Graft-versus-host disease_Homo sapiens_hsa053320.55267399
125Dilated cardiomyopathy_Homo sapiens_hsa054140.55190379
126Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54847819
127Nitrogen metabolism_Homo sapiens_hsa009100.53865624
128Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51167314
129Leukocyte transendothelial migration_Homo sapiens_hsa046700.50292873
130SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50037015
131Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50035943
132mTOR signaling pathway_Homo sapiens_hsa041500.49915263
133Alcoholism_Homo sapiens_hsa050340.49877217
134Renal cell carcinoma_Homo sapiens_hsa052110.49602379
135Chronic myeloid leukemia_Homo sapiens_hsa052200.47926538
136HIF-1 signaling pathway_Homo sapiens_hsa040660.46919499
137Circadian rhythm_Homo sapiens_hsa047100.42738435
138Transcriptional misregulation in cancer_Homo sapiens_hsa052020.42303073
139Lysosome_Homo sapiens_hsa041420.40752325
140Regulation of autophagy_Homo sapiens_hsa041400.39044999
141Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.38519187
142Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36278239

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »