CYMP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)9.17721227
2positive regulation of heterotypic cell-cell adhesion (GO:0034116)8.53070411
3protein targeting to Golgi (GO:0000042)8.52477725
4establishment of protein localization to Golgi (GO:0072600)8.15171931
5retrograde transport, vesicle recycling within Golgi (GO:0000301)8.05459916
6fusion of sperm to egg plasma membrane (GO:0007342)7.74478095
7acrosome reaction (GO:0007340)7.27851119
8glomerular visceral epithelial cell development (GO:0072015)6.42915711
9protein polyglutamylation (GO:0018095)6.28602806
10chromosome condensation (GO:0030261)6.20384128
11protein localization to Golgi apparatus (GO:0034067)6.14650675
12DNA packaging (GO:0006323)5.99762164
13seminiferous tubule development (GO:0072520)5.99269697
14regulation of centriole replication (GO:0046599)5.82202735
15glomerular epithelial cell development (GO:0072310)5.81319666
16sperm capacitation (GO:0048240)5.77648960
17plasma membrane fusion (GO:0045026)5.76037520
18centriole replication (GO:0007099)5.47148287
19sexual reproduction (GO:0019953)5.40205295
20spermatogenesis (GO:0007283)5.33065813
21male gamete generation (GO:0048232)5.31076675
22rRNA methylation (GO:0031167)5.30828875
23microtubule polymerization or depolymerization (GO:0031109)5.22406492
24multicellular organism reproduction (GO:0032504)5.12235484
25reproduction (GO:0000003)5.02859391
26spermatid development (GO:0007286)5.01398018
27microtubule depolymerization (GO:0007019)4.95112861
28gamete generation (GO:0007276)4.86671707
29single strand break repair (GO:0000012)4.82992488
30centriole assembly (GO:0098534)4.78165618
31sperm-egg recognition (GO:0035036)4.75045016
32phosphatidylethanolamine biosynthetic process (GO:0006646)4.71848650
33regulation of heterotypic cell-cell adhesion (GO:0034114)4.69171124
34spermatid nucleus differentiation (GO:0007289)4.61405620
35positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)4.57219211
36phosphatidylethanolamine metabolic process (GO:0046337)4.35188216
37establishment of apical/basal cell polarity (GO:0035089)4.34317972
38cell wall macromolecule catabolic process (GO:0016998)4.32757348
39heme transport (GO:0015886)4.29606828
40single fertilization (GO:0007338)4.25611567
41rRNA modification (GO:0000154)4.22006569
42fertilization (GO:0009566)4.20353388
43phospholipid efflux (GO:0033700)4.18912738
44axonemal dynein complex assembly (GO:0070286)4.17898075
45microtubule nucleation (GO:0007020)4.13757485
46calcium ion-dependent exocytosis (GO:0017156)4.11285682
47nuclear pore complex assembly (GO:0051292)4.11025902
48polarized epithelial cell differentiation (GO:0030859)4.07817881
49cell wall macromolecule metabolic process (GO:0044036)4.02545730
50multicellular organismal reproductive process (GO:0048609)3.93203689
51RNA destabilization (GO:0050779)3.88902558
52binding of sperm to zona pellucida (GO:0007339)3.85237697
53multicellular organismal movement (GO:0050879)3.82840953
54musculoskeletal movement (GO:0050881)3.82840953
55cell-cell recognition (GO:0009988)3.82179458
56intra-Golgi vesicle-mediated transport (GO:0006891)3.78287929
57establishment of monopolar cell polarity (GO:0061162)3.70023724
58establishment or maintenance of monopolar cell polarity (GO:0061339)3.70023724
59microtubule severing (GO:0051013)3.69799136
60cilium or flagellum-dependent cell motility (GO:0001539)3.67325888
61cellular zinc ion homeostasis (GO:0006882)3.56268276
62plasma lipoprotein particle assembly (GO:0034377)3.48808692
63C4-dicarboxylate transport (GO:0015740)3.47710820
64positive regulation of Rab GTPase activity (GO:0032851)3.44681916
65regulation of Rab GTPase activity (GO:0032313)3.44681916
66motile cilium assembly (GO:0044458)3.42186975
67response to vitamin A (GO:0033189)3.38169715
68negative regulation of endothelial cell apoptotic process (GO:2000352)3.28562674
69bundle of His cell to Purkinje myocyte communication (GO:0086069)3.27541646
70insulin-like growth factor receptor signaling pathway (GO:0048009)3.24010282
71regulation of chemokine secretion (GO:0090196)3.23869970
72regulation of cholesterol esterification (GO:0010872)3.23852702
73epithelial cilium movement (GO:0003351)3.23064624
74regulation of hippo signaling (GO:0035330)3.22614173
75regulation of acrosome reaction (GO:0060046)3.19552101
76regulation of cilium movement (GO:0003352)3.14740018
77iron coordination entity transport (GO:1901678)3.12314685
78estrogen biosynthetic process (GO:0006703)3.11746971
79regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.11558142
80receptor recycling (GO:0001881)3.11187766
81response to pheromone (GO:0019236)3.10968244
82negative regulation of protein activation cascade (GO:2000258)3.08525943
83hemoglobin metabolic process (GO:0020027)3.07394123
84protein-lipid complex assembly (GO:0065005)3.07198112
85germ cell development (GO:0007281)3.06559539
86pore complex assembly (GO:0046931)3.04444269
87nuclear pore organization (GO:0006999)3.04118641
88establishment of epithelial cell polarity (GO:0090162)2.97304123
89toxin transport (GO:1901998)2.96758818
90cellular process involved in reproduction in multicellular organism (GO:0022412)2.95917657
91ovulation from ovarian follicle (GO:0001542)2.94128718
92regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)2.93584636
93nucleus organization (GO:0006997)2.91632778
94thrombin receptor signaling pathway (GO:0070493)2.85703442
95oligosaccharide catabolic process (GO:0009313)2.82513685
96negative regulation of sodium ion transport (GO:0010766)2.81557651
97cilium movement (GO:0003341)2.81306869
98peptidyl-glutamic acid modification (GO:0018200)2.76685355
99positive regulation of substrate adhesion-dependent cell spreading (GO:1900026)2.74643874
100negative regulation of inclusion body assembly (GO:0090084)2.72145027

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.55200451
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.12278119
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.52897319
4MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.12488198
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.91114373
6FUS_26573619_Chip-Seq_HEK293_Human2.06107331
7ARNT_22903824_ChIP-Seq_MCF-7_Human1.99720691
8IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.92637866
9CBP_20019798_ChIP-Seq_JUKART_Human1.92637866
10POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.83244850
11TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.83244850
12CTBP1_25329375_ChIP-Seq_LNCAP_Human1.80869517
13ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.74850212
14GBX2_23144817_ChIP-Seq_PC3_Human1.73205516
15AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.72081146
16AHR_22903824_ChIP-Seq_MCF-7_Human1.64450789
17CTBP2_25329375_ChIP-Seq_LNCAP_Human1.62410206
18SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.61078863
19ZNF217_24962896_ChIP-Seq_MCF-7_Human1.58726382
20P300_19829295_ChIP-Seq_ESCs_Human1.54851971
21TP53_18474530_ChIP-ChIP_U2OS_Human1.53901463
22DROSHA_22980978_ChIP-Seq_HELA_Human1.52172584
23CDX2_19796622_ChIP-Seq_MESCs_Mouse1.52081385
24EZH2_22144423_ChIP-Seq_EOC_Human1.51109112
25SMAD3_21741376_ChIP-Seq_EPCs_Human1.51086117
26PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.49894003
27TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.48316651
28* RAC3_21632823_ChIP-Seq_H3396_Human1.47068196
29SMAD4_21741376_ChIP-Seq_HESCs_Human1.45463573
30SMAD4_21741376_ChIP-Seq_EPCs_Human1.45014645
31UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.44299695
32* CBX2_22325352_ChIP-Seq_293T-Rex_Human1.39549439
33NFIB_24661679_ChIP-Seq_LUNG_Mouse1.39537461
34CJUN_26792858_Chip-Seq_BT549_Human1.35556175
35* GATA4_25053715_ChIP-Seq_YYC3_Human1.34625813
36* EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.34328916
37VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.32828418
38SMAD4_21799915_ChIP-Seq_A2780_Human1.32722101
39ER_23166858_ChIP-Seq_MCF-7_Human1.32480609
40AR_25329375_ChIP-Seq_VCAP_Human1.30923938
41ETV1_20927104_ChIP-Seq_GIST48_Human1.30344008
42FOXA2_19822575_ChIP-Seq_HepG2_Human1.30302465
43CEBPB_22108803_ChIP-Seq_LS180_Human1.30273601
44HNFA_21074721_ChIP-Seq_CACO-2_Human1.28655761
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.28471295
46ERA_21632823_ChIP-Seq_H3396_Human1.27665509
47TBL1_22424771_ChIP-Seq_293T_Human1.26346888
48SALL1_21062744_ChIP-ChIP_HESCs_Human1.24311824
49EGR1_23403033_ChIP-Seq_LIVER_Mouse1.23718721
50SMAD3_21741376_ChIP-Seq_ESCs_Human1.23410814
51* RBPJ_21746931_ChIP-Seq_IB4_Human1.23261630
52MYC_19829295_ChIP-Seq_ESCs_Human1.20771499
53AR_21572438_ChIP-Seq_LNCaP_Human1.20716927
54NFYB_21822215_ChIP-Seq_K562_Human1.20381996
55SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19227243
56WDR5_24793694_ChIP-Seq_LNCAP_Human1.18736732
57AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.17389560
58FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.16955841
59RUNX2_22187159_ChIP-Seq_PCA_Human1.16229622
60PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.15721130
61FOXA1_21572438_ChIP-Seq_LNCaP_Human1.15621033
62* CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.14754885
63STAT3_23295773_ChIP-Seq_U87_Human1.12542648
64EP300_21415370_ChIP-Seq_HL-1_Mouse1.10919208
65CTCF_27219007_Chip-Seq_Bcells_Human1.10782948
66* PHF8_20622853_ChIP-Seq_HELA_Human1.10480914
67TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10228118
68* TP63_22573176_ChIP-Seq_HFKS_Human1.09742032
69SOX2_22085726_ChIP-Seq_NPCs_Mouse1.08269355
70ETV2_25802403_ChIP-Seq_MESCs_Mouse1.08003374
71AUTS2_25519132_ChIP-Seq_293T-REX_Human1.07304031
72ZNF274_21170338_ChIP-Seq_K562_Hela1.06789706
73* TP63_23658742_ChIP-Seq_EP156T_Human1.05455750
74EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.05434653
75TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05000642
76KLF5_25053715_ChIP-Seq_YYC3_Human1.04765197
77PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.03627754
78ERG_20517297_ChIP-Seq_VCAP_Human1.02814998
79TAF15_26573619_Chip-Seq_HEK293_Human1.02003958
80GATA3_21878914_ChIP-Seq_MCF-7_Human1.01652928
81NFYA_21822215_ChIP-Seq_K562_Human1.01049547
82BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.00328884
83PPAR_26484153_Chip-Seq_NCI-H1993_Human0.99250478
84* GATA6_25053715_ChIP-Seq_YYC3_Human0.96882172
85NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96369348
86SMC4_20622854_ChIP-Seq_HELA_Human0.94387325
87CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.93148740
88GF1_26923725_Chip-Seq_HPCs_Mouse0.92606292
89KDM2B_26808549_Chip-Seq_REH_Human0.92541356
90NANOG_20526341_ChIP-Seq_ESCs_Human0.91943891
91TDRD3_21172665_ChIP-Seq_MCF-7_Human0.91699150
92* GATA6_21074721_ChIP-Seq_CACO-2_Human0.91357826
93TCF4_18268006_ChIP-ChIP_LS174T_Human0.90658526
94* OCT4_20526341_ChIP-Seq_ESCs_Human0.90136343
95FOXO3_23340844_ChIP-Seq_DLD1_Human0.89981395
96FOXA1_27270436_Chip-Seq_PROSTATE_Human0.89910863
97FOXA1_25329375_ChIP-Seq_VCAP_Human0.89910863
98KLF5_20875108_ChIP-Seq_MESCs_Mouse0.89837970
99LXR_22158963_ChIP-Seq_LIVER_Mouse0.89458698
100SUZ12_27294783_Chip-Seq_ESCs_Mouse0.89327149

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization8.13362737
2MP0002254_reproductive_system_inflammat6.18138765
3MP0002876_abnormal_thyroid_physiology4.45239116
4MP0003878_abnormal_ear_physiology4.41106044
5MP0005377_hearing/vestibular/ear_phenot4.41106044
6MP0005451_abnormal_body_composition3.76633062
7MP0005670_abnormal_white_adipose3.31025851
8MP0009840_abnormal_foam_cell3.11979331
9MP0004272_abnormal_basement_membrane3.09040407
10MP0003698_abnormal_male_reproductive2.82486136
11MP0004264_abnormal_extraembryonic_tissu2.71349414
12MP0001348_abnormal_lacrimal_gland2.67269477
13MP0001929_abnormal_gametogenesis2.41197304
14MP0005379_endocrine/exocrine_gland_phen2.36491869
15MP0003300_gastrointestinal_ulcer2.14037909
16MP0003329_amyloid_beta_deposits1.96720405
17MP0003879_abnormal_hair_cell1.89199648
18MP0000604_amyloidosis1.86690370
19MP0003718_maternal_effect1.67213332
20MP0003191_abnormal_cellular_cholesterol1.64618848
21MP0002161_abnormal_fertility/fecundity1.63902931
22MP0010329_abnormal_lipoprotein_level1.63184895
23MP0003941_abnormal_skin_development1.46919366
24MP0004270_analgesia1.46241383
25MP0001666_abnormal_nutrient_absorption1.36998526
26MP0001486_abnormal_startle_reflex1.36801081
27MP0003632_abnormal_nervous_system1.22580204
28MP0005332_abnormal_amino_acid1.21196882
29MP0000681_abnormal_thyroid_gland1.18030090
30MP0005623_abnormal_meninges_morphology1.17207088
31MP0005551_abnormal_eye_electrophysiolog1.15153127
32MP0002282_abnormal_trachea_morphology1.15127010
33MP0001485_abnormal_pinna_reflex1.14621697
34MP0003646_muscle_fatigue1.12808726
35MP0009643_abnormal_urine_homeostasis1.09750206
36MP0005310_abnormal_salivary_gland1.09245244
37MP0005636_abnormal_mineral_homeostasis1.08664005
38MP0005408_hypopigmentation1.08598221
39MP0003950_abnormal_plasma_membrane1.08246223
40MP0002136_abnormal_kidney_physiology1.06729603
41MP0005058_abnormal_lysosome_morphology1.04977464
42MP0001963_abnormal_hearing_physiology1.03484829
43MP0001984_abnormal_olfaction0.99780203
44MP0002132_abnormal_respiratory_system0.99029456
45MP0003385_abnormal_body_wall0.98914541
46MP0005084_abnormal_gallbladder_morpholo0.97533343
47MP0002138_abnormal_hepatobiliary_system0.96423121
48MP0002089_abnormal_postnatal_growth/wei0.94639636
49MP0005409_darkened_coat_color0.91680488
50MP0002210_abnormal_sex_determination0.90602557
51MP0004233_abnormal_muscle_weight0.90538924
52MP0001145_abnormal_male_reproductive0.89027899
53MP0002295_abnormal_pulmonary_circulatio0.86314696
54MP0002557_abnormal_social/conspecific_i0.84525958
55MP0003011_delayed_dark_adaptation0.84335773
56MP0005595_abnormal_vascular_smooth0.84040581
57MP0003631_nervous_system_phenotype0.83466552
58MP0005666_abnormal_adipose_tissue0.79972760
59MP0000653_abnormal_sex_gland0.79768973
60MP0004019_abnormal_vitamin_homeostasis0.78628306
61MP0001765_abnormal_ion_homeostasis0.77973677
62MP0005023_abnormal_wound_healing0.76508673
63MP0004133_heterotaxia0.76453108
64MP0004084_abnormal_cardiac_muscle0.74320422
65MP0000230_abnormal_systemic_arterial0.73905239
66MP0005085_abnormal_gallbladder_physiolo0.72862473
67MP0001873_stomach_inflammation0.72820958
68MP0005167_abnormal_blood-brain_barrier0.71916246
69MP0005365_abnormal_bile_salt0.70642868
70MP0001958_emphysema0.70272328
71MP0002098_abnormal_vibrissa_morphology0.69566508
72MP0005395_other_phenotype0.68835147
73MP0006138_congestive_heart_failure0.68762862
74MP0004742_abnormal_vestibular_system0.68385175
75MP0000026_abnormal_inner_ear0.68020363
76MP0002127_abnormal_cardiovascular_syste0.67698810
77MP0002229_neurodegeneration0.67340442
78MP0001299_abnormal_eye_distance/0.65824021
79MP0004036_abnormal_muscle_relaxation0.64778133
80MP0002135_abnormal_kidney_morphology0.61754540
81MP0009053_abnormal_anal_canal0.60907931
82MP0002932_abnormal_joint_morphology0.58637753
83MP0003633_abnormal_nervous_system0.58272131
84MP0004782_abnormal_surfactant_physiolog0.58215139
85MP0004858_abnormal_nervous_system0.58102352
86MP0005083_abnormal_biliary_tract0.56944184
87MP0003137_abnormal_impulse_conducting0.54399591
88MP0002118_abnormal_lipid_homeostasis0.53746887
89MP0003122_maternal_imprinting0.52037709
90MP0008004_abnormal_stomach_pH0.51223679
91MP0003172_abnormal_lysosome_physiology0.50858777
92MP0008872_abnormal_physiological_respon0.50729801
93MP0003119_abnormal_digestive_system0.50417216
94MP0005253_abnormal_eye_physiology0.49791104
95MP0005166_decreased_susceptibility_to0.49241487
96MP0009115_abnormal_fat_cell0.48740335
97MP0009384_cardiac_valve_regurgitation0.46946764
98MP0001614_abnormal_blood_vessel0.46636473
99MP0003634_abnormal_glial_cell0.44895408
100MP0003115_abnormal_respiratory_system0.44526513

Predicted human phenotypes

RankGene SetZ-score
1Spontaneous abortion (HP:0005268)7.98983087
2Hypoalphalipoproteinemia (HP:0003233)5.89344041
3Chronic hepatic failure (HP:0100626)5.52204669
4Asymmetric septal hypertrophy (HP:0001670)5.38441976
5Tubulointerstitial nephritis (HP:0001970)5.07132762
6Cone-rod dystrophy (HP:0000548)5.01965427
7Retinal atrophy (HP:0001105)4.63165598
8Abnormality of the common coagulation pathway (HP:0010990)4.10729913
9Osteomalacia (HP:0002749)4.06112816
10Vacuolated lymphocytes (HP:0001922)3.93609838
11Abnormality of macular pigmentation (HP:0008002)3.91066307
12Gingival bleeding (HP:0000225)3.81741726
13Hypolipoproteinemia (HP:0010981)3.68306421
14Stage 5 chronic kidney disease (HP:0003774)3.65573646
15Hyperkalemia (HP:0002153)3.62910301
16Flat capital femoral epiphysis (HP:0003370)3.61463130
17Absent/shortened dynein arms (HP:0200106)3.60408202
18Dynein arm defect of respiratory motile cilia (HP:0012255)3.60408202
19Malnutrition (HP:0004395)3.59456679
20Flattened epiphyses (HP:0003071)3.58042896
21Renovascular hypertension (HP:0100817)3.55002901
22Male infertility (HP:0003251)3.50266267
23Severe visual impairment (HP:0001141)3.30856164
24Truncal obesity (HP:0001956)3.24657836
25Abnormal delivery (HP:0001787)3.13377799
26Amelogenesis imperfecta (HP:0000705)3.12861000
27Amyloidosis (HP:0011034)3.12574850
28Subcapsular cataract (HP:0000523)3.05011501
29Impulsivity (HP:0100710)3.04018905
30Neonatal short-limb short stature (HP:0008921)2.97601644
31Abnormality of the ischium (HP:0003174)2.95263769
32Abnormality of dental color (HP:0011073)2.94280098
33Cerebellar dysplasia (HP:0007033)2.79357203
34Menstrual irregularities (HP:0000858)2.77198620
35Intellectual disability, moderate (HP:0002342)2.76395481
36Cervical subluxation (HP:0003308)2.76342084
37Abnormality of macrophages (HP:0004311)2.73676290
38Focal segmental glomerulosclerosis (HP:0000097)2.71190623
39Vertebral clefting (HP:0008428)2.62080314
40Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.61299080
41Hypoplasia of the thymus (HP:0000778)2.57121068
42Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.52661551
43Joint swelling (HP:0001386)2.51428221
44Progressive sensorineural hearing impairment (HP:0000408)2.50016610
45Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.48940019
46Abnormal ciliary motility (HP:0012262)2.45802951
47Abnormal respiratory motile cilium physiology (HP:0012261)2.45211473
48Nasal polyposis (HP:0100582)2.44910380
49Tubulointerstitial abnormality (HP:0001969)2.39972513
50Flat acetabular roof (HP:0003180)2.38124459
51Infertility (HP:0000789)2.38086649
52Resting tremor (HP:0002322)2.37807930
53Goiter (HP:0000853)2.36004862
54Abnormality of pyrimidine metabolism (HP:0004353)2.33416360
55Potter facies (HP:0002009)2.31245549
56Facial shape deformation (HP:0011334)2.31245549
57Aplasia/Hypoplasia of the earlobes (HP:0009906)2.29820315
58Hypophosphatemic rickets (HP:0004912)2.27273785
59Insulin-resistant diabetes mellitus (HP:0000831)2.26125404
60Portal hypertension (HP:0001409)2.25072644
61Exocrine pancreatic insufficiency (HP:0001738)2.23901981
62Abnormality of the acetabulum (HP:0003170)2.23767322
63Abnormality of monocarboxylic acid metabolism (HP:0010996)2.22873258
64Abnormality of the pubic bones (HP:0003172)2.14994444
65Progressive cerebellar ataxia (HP:0002073)2.14052320
66Abnormal respiratory motile cilium morphology (HP:0005938)2.10203410
67Abnormal respiratory epithelium morphology (HP:0012253)2.10203410
68Attenuation of retinal blood vessels (HP:0007843)2.10040089
69Hypoplastic ischia (HP:0003175)2.09542774
70Glomerulosclerosis (HP:0000096)2.08579008
71Midline defect of the nose (HP:0004122)2.07924534
72Limited hip movement (HP:0008800)2.05669407
73Absent eyebrow (HP:0002223)2.04825747
74Vitreoretinal degeneration (HP:0000655)2.04424335
75Decreased central vision (HP:0007663)2.03203039
76Abnormality of the hepatic vasculature (HP:0006707)2.03091856
77Ventricular tachycardia (HP:0004756)2.01198866
78Mesangial abnormality (HP:0001966)1.99810380
79Abnormality of transition element cation homeostasis (HP:0011030)1.96505254
80Increased purine levels (HP:0004368)1.93819555
81Hyperuricemia (HP:0002149)1.93819555
82Right ventricular cardiomyopathy (HP:0011663)1.93446902
83Esophageal varix (HP:0002040)1.90453722
84Occipital encephalocele (HP:0002085)1.83915877
85Delayed epiphyseal ossification (HP:0002663)1.82930298
86Abnormality of urine glucose concentration (HP:0011016)1.81859930
87Glycosuria (HP:0003076)1.81859930
88Bilateral sensorineural hearing impairment (HP:0008619)1.80996330
89Abnormality of the nasal mucosa (HP:0000433)1.80687888
90Thoracolumbar scoliosis (HP:0002944)1.80662589
91Myocardial infarction (HP:0001658)1.80590613
92Osteoarthritis (HP:0002758)1.77701340
93Beaking of vertebral bodies (HP:0004568)1.76407733
94Nephritis (HP:0000123)1.74908449
95Hypoparathyroidism (HP:0000829)1.73834790
96Rhinitis (HP:0012384)1.71970603
97Short tibia (HP:0005736)1.70333151
98Aplasia/Hypoplasia of the tibia (HP:0005772)1.69730489
99Arthropathy (HP:0003040)1.69720021
100Chronic bronchitis (HP:0004469)1.69250970

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK49.06562090
2INSRR4.29105948
3BRD44.12421546
4PIK3CG3.95613809
5PNCK3.79341346
6TYRO33.78801505
7PLK23.26328169
8LMTK22.58272886
9CAMK1G2.42075995
10STK382.33809420
11TESK12.27925005
12CASK2.09302003
13NEK62.00042644
14PDPK11.52989998
15STK38L1.48613091
16PDK11.42227755
17MAP3K121.37158019
18NTRK31.33144107
19TIE11.28800715
20PDK21.23011701
21MAP4K21.21366622
22PRKG21.16791352
23FGFR41.11632458
24SGK2231.06940203
25SGK4941.06940203
26CDK121.06288550
27STK391.05791946
28AKT31.05490324
29DDR21.01810417
30CAMK1D0.98281775
31MAPK150.96026887
32MAP3K90.95709936
33MAP3K20.88974408
34MAP3K110.86836988
35WNK10.86139258
36PRKD30.85265672
37LATS10.79741711
38PTK2B0.79212136
39ICK0.77896649
40MST1R0.71434520
41SGK20.70213582
42PRKCG0.67962464
43GRK10.67756776
44FER0.66061025
45LATS20.64763970
46PRKG10.61505553
47MTOR0.60633204
48MET0.60414236
49FGFR20.60079966
50BMPR1B0.55812012
51OXSR10.52225692
52SGK30.52171813
53WNK40.51312368
54PRKAA20.50593369
55ACVR1B0.50590894
56ROCK10.49085259
57PRKACB0.47711365
58MAP2K20.47448169
59BRAF0.46549791
60TESK20.43693774
61EPHA20.43677926
62FGFR30.42931034
63KSR20.41738060
64DYRK1B0.41575282
65PRKCZ0.39780683
66CAMK40.38928569
67JAK30.38501864
68MAP2K10.38241543
69MAP3K10.35823525
70CAMK10.35141244
71MAPK10.34699462
72CSNK1A10.33075572
73CSNK1D0.32732845
74RIPK10.29694864
75PTK60.29130650
76PRKCB0.28313061
77ERBB20.28243303
78CDK70.27698013
79PRKAA10.27471546
80SGK10.26830561
81GSK3B0.25973209
82WNK30.25970055
83PRKACG0.25023560
84MAP3K40.24164664
85DYRK20.23283561
86FGFR10.21457152
87CDK10.21174505
88MARK10.20034337
89CHUK0.19632091
90ERN10.18390741
91EPHA30.17769688
92RPS6KA10.17061658
93BRSK20.16674571
94RET0.16199812
95MAPK140.15783237
96MAPK80.11798877
97RPS6KA20.11117862
98PRKACA0.10920681
99JAK20.10846832
100BRSK10.10838414

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000614.53409702
2Other glycan degradation_Homo sapiens_hsa005113.28049754
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.23488975
4ECM-receptor interaction_Homo sapiens_hsa045122.93059035
5Olfactory transduction_Homo sapiens_hsa047402.77405177
6Complement and coagulation cascades_Homo sapiens_hsa046102.64065061
7Protein digestion and absorption_Homo sapiens_hsa049742.63525843
8Fat digestion and absorption_Homo sapiens_hsa049752.51818485
9Glycosaminoglycan degradation_Homo sapiens_hsa005312.14198653
10Sphingolipid metabolism_Homo sapiens_hsa006002.06914468
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.76886262
12Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.64617908
13Vitamin digestion and absorption_Homo sapiens_hsa049771.64362663
14Fatty acid degradation_Homo sapiens_hsa000711.56724809
15ABC transporters_Homo sapiens_hsa020101.55075320
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.54857332
17Glycerophospholipid metabolism_Homo sapiens_hsa005641.53813231
18Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.53473945
19Fatty acid metabolism_Homo sapiens_hsa012121.49147985
20Inositol phosphate metabolism_Homo sapiens_hsa005621.46702275
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.37611228
22Arginine biosynthesis_Homo sapiens_hsa002201.36574209
23PPAR signaling pathway_Homo sapiens_hsa033201.35358866
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.33996788
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.32125430
26Focal adhesion_Homo sapiens_hsa045101.31028865
27Thyroid hormone synthesis_Homo sapiens_hsa049181.25239169
28Mineral absorption_Homo sapiens_hsa049781.25133032
29Tight junction_Homo sapiens_hsa045301.25110104
30Steroid biosynthesis_Homo sapiens_hsa001001.24780297
31Phototransduction_Homo sapiens_hsa047441.24009035
32N-Glycan biosynthesis_Homo sapiens_hsa005101.21806450
33Nitrogen metabolism_Homo sapiens_hsa009101.15898173
34Synaptic vesicle cycle_Homo sapiens_hsa047211.15889705
35Butanoate metabolism_Homo sapiens_hsa006501.06894411
36Phosphatidylinositol signaling system_Homo sapiens_hsa040701.01261529
37Taste transduction_Homo sapiens_hsa047421.01011034
38Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.95910336
39Maturity onset diabetes of the young_Homo sapiens_hsa049500.94292051
40Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.93430847
41Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.93086908
42Pentose and glucuronate interconversions_Homo sapiens_hsa000400.92068339
43Thyroid hormone signaling pathway_Homo sapiens_hsa049190.91387010
44Bile secretion_Homo sapiens_hsa049760.90124573
45Primary bile acid biosynthesis_Homo sapiens_hsa001200.89848546
46Chemical carcinogenesis_Homo sapiens_hsa052040.89094144
47Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.88652335
48Small cell lung cancer_Homo sapiens_hsa052220.84906294
49Lysosome_Homo sapiens_hsa041420.84035193
50Adherens junction_Homo sapiens_hsa045200.80757305
51Aldosterone synthesis and secretion_Homo sapiens_hsa049250.78733550
52AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.76604059
53Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.75515411
54Type II diabetes mellitus_Homo sapiens_hsa049300.73968866
55RNA transport_Homo sapiens_hsa030130.72047424
56Tyrosine metabolism_Homo sapiens_hsa003500.70621755
57Phenylalanine metabolism_Homo sapiens_hsa003600.70119626
58Adipocytokine signaling pathway_Homo sapiens_hsa049200.69412243
59Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.68975324
60Endocytosis_Homo sapiens_hsa041440.68383239
61VEGF signaling pathway_Homo sapiens_hsa043700.67311590
62African trypanosomiasis_Homo sapiens_hsa051430.67148778
63Amoebiasis_Homo sapiens_hsa051460.66611382
64Pancreatic secretion_Homo sapiens_hsa049720.64127650
65Retinol metabolism_Homo sapiens_hsa008300.63901950
66Dorso-ventral axis formation_Homo sapiens_hsa043200.62779414
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62377310
68Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.56863647
69cAMP signaling pathway_Homo sapiens_hsa040240.54927705
70Glutamatergic synapse_Homo sapiens_hsa047240.52832994
71Starch and sucrose metabolism_Homo sapiens_hsa005000.51718914
72Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49697608
73Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49534382
74Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.48890623
75Hippo signaling pathway_Homo sapiens_hsa043900.48802682
76Glutathione metabolism_Homo sapiens_hsa004800.48736927
77Calcium signaling pathway_Homo sapiens_hsa040200.43460915
78Cardiac muscle contraction_Homo sapiens_hsa042600.42764620
79Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41617178
80Salivary secretion_Homo sapiens_hsa049700.41304293
81Nicotine addiction_Homo sapiens_hsa050330.39880080
82Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.37279881
83Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.37103177
84Renin-angiotensin system_Homo sapiens_hsa046140.36851230
85Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.36220541
86Platelet activation_Homo sapiens_hsa046110.35956789
87Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.35518873
88Arginine and proline metabolism_Homo sapiens_hsa003300.35113585
89Renin secretion_Homo sapiens_hsa049240.34891826
90PI3K-Akt signaling pathway_Homo sapiens_hsa041510.34589033
91Gastric acid secretion_Homo sapiens_hsa049710.34282977
92TGF-beta signaling pathway_Homo sapiens_hsa043500.33953304
93Hedgehog signaling pathway_Homo sapiens_hsa043400.33845390
94Sulfur relay system_Homo sapiens_hsa041220.33173377
95Toxoplasmosis_Homo sapiens_hsa051450.32687975
96Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.32520112
97Glycerolipid metabolism_Homo sapiens_hsa005610.31465882
98Carbohydrate digestion and absorption_Homo sapiens_hsa049730.30387907
99Galactose metabolism_Homo sapiens_hsa000520.29210612
100HIF-1 signaling pathway_Homo sapiens_hsa040660.28950628

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